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Orelabrutinib (ICP-022) is a potent, orally active, and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Orelabrutinib prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICP-022. CAS No. 1655504-04-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129390.
Orelabrutinib
Orelabrutinib, also known as ICP-022, is a potent, orally active, and irreversible Bruton's tyrosine kinase (BTK) inhibitor, being developed by InnoCare Pharma, for the treatment of chronic lymphocytic leukaemia. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Orelabrutinib; ICP-022; ICP022; ICP 022. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1655504-04-3. Molecular formula: C26H25N3O3. Mole weight: 427.5. Purity: >98%. IUPACName: 2-(4-phenoxyphenyl)-6-[1-(prop-2-enoyl)piperidin- 4-yl]pyridine-3-carboxamide. Canonical SMILES: O=C(C1=CC=C(C2CCN(C(C=C)=O)CC2)N=C1C3=CC=C(OC4=CC=CC=C4)C=C3)N. Product ID: ACM1655504043. Alfa Chemistry ISO 9001:2015 Certified.
Oreoch-1
Oreoch-1 is an antimicrobial peptide found in Oreochromis niloticus, and has antibacterial and antifungal activity. Synonyms: Phe-Ile-His-His-Ile-Ile-Gly-Gly-Leu-Phe-Ser-Val-Gly-Lys-His-Ile-His-Gly-Leu-Ile-His-Gly-His; oreochromicin-1; Oreochromicin I. Grade: ≥95%.
Oreoch-3
Oreoch-3 is an antimicrobial peptide found in Oreochromis niloticus (Nile tilapia), and has antibacterial and antifungal activity. Synonyms: oreochromicin-3; Oreochromicin III. Grade: >98%.
Orexin 2 Receptor Agonist
Orexin 2 Receptor Agonist is a potent selective OX2R agonist with an EC 50 of 23 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1796565-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19320.
Orexin 2 Receptor Agonist 2
Orexin 2 Receptor Agonist 2 is a selective orexin 2 receptor agonist, extracted from patent WO2017135306A1, example 16 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2114324-60-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138695.
Orexin A (1-15) (free acid)
Orexin A (1-15) (free acid) is the N-terminal segment of orexin A and contains two disulfide bonds. Synonyms: Hypocretin-1 (1-15) (Human, Mouse, Rat); Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-OH (Disulfide bridge: Cys6-Cys12, Cys7-Cys14). Grade: ≥95%. CAS No. 2022956-49-4. Molecular formula: C67H109N23O22S4. Mole weight: 1717.01.
Orexin A (16-33)
Orexin A (16-33) lacks the disulfide bridge of orexin A, but retains part of the full-length OXA/OXB activity. It has been used in place of intact neuropeptides. Synonyms: Hypocretin-1 (16-33) (Human, Mouse Rat); H-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2; L-leucyl-L-tyrosyl-L-alpha-glutamyl-L-leucyl-L-leucyl-L-histidyl-glycyl-L-alanyl-glycyl-L-asparagyl-L-histidyl-L-alanyl-L-alanyl-glycyl-L-isoleucyl-L-leucyl-L-threonyl-L-leucinamide; OXA 16-33. Grade: ≥95%. CAS No. 1374694-00-4. Molecular formula: C85H136N24O23. Mole weight: 1862.16.
Orexin A (human, rat, mouse)
An orexin receptors agonist. It can stimulate feeding following central administration. Grade: 95%. CAS No. 205640-90-0. Molecular formula: C152H243N47O44S4. Mole weight: 3561.12.
Orexin A (human, rat, mouse)
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor ( OX1R ) and the orexin-2 receptor ( OX2R ). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Hypocretin-1 (human, rat, mouse). CAS No. 205640-90-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-106224.
Orexin A (human, rat, mouse) acetate
Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging[1][2][3][4]. Uses: Scientific research. Group: Peptides. Alternative Names: Hypocretin-1 (human, rat, mouse) acetate. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-106224B.
Orexin b(human)
Orexin b(human). Uses: Designed for use in research and industrial production. Additional or Alternative Names: ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2;HYPOCRETIN-2;HYPOCRETIN-2, HUMAN;H-ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU. Product Category: Heterocyclic Organic Compound. CAS No. 205640-91-1. Molecular formula: C123H212N44O35S. Product ID: ACM205640911. Alfa Chemistry ISO 9001:2015 Certified.
Orexin B human
An orexin receptors agonist. It can stimulate feeding following central administration. Synonyms: Human orexin B. Grade: ≥95% by HPLC. CAS No. 205640-91-1. Molecular formula: C123H212N44O35S. Mole weight: 2899.36.
Orexin B, human TFA
An orexin receptors agonist. It can stimulate feeding following central administration. Synonyms: Human orexin B (TFA); Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2.TFA; L-arginyl-L-seryl-glycyl-L-prolyl-L-prolyl-glycyl-L-leucyl-L-glutaminyl-glycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-seryl-glycyl-L-asparagyl-L-histidyl-L-alanyl-L-alanyl-glycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide trifluoroacetic acid. Grade: ≥98%. Molecular formula: C123H212N44O35S.C2HF3O2. Mole weight: 3013.36.
Orexin B (rat, mouse)
An orexin receptors agonist. It can stimulate feeding following central administration. Synonyms: Rat orexin B; Orexin B (mouse); H-Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2; L-arginyl-L-prolyl-glycyl-L-prolyl-L-prolyl-glycyl-L-leucyl-L-glutaminyl-glycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-asparagyl-glycyl-L-asparagyl-L-histidyl-L-alanyl-L-alanyl-glycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide. Grade: ≥95% by HPLC. CAS No. 202801-92-1. Molecular formula: C126H215N45O34S. Mole weight: 2936.39.
Orexin B, rat, mouse
Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with K i s of 420 and 36 nM for OX1 and OX2, respectively. Uses: Scientific research. Group: Peptides. Alternative Names: Rat orexin B; Orexin B (mouse). CAS No. 202801-92-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1349.
Orexin receptor antagonist 2
Orexin receptor antagonist 2 (compound 30) is a potent orexin receptor antagonist with pK i s of 7.69 and 9.78. Orexin receptor antagonist 2 has the potential for the research of insomnia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1457940-75-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-136922.
Orexin receptor antagonist 3
Orexin receptor antagonist 3 (example 216) is an orexin receptor antagonist, which is extracted from the patent WO2011050198A1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1293282-55-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-137093.
Orfamide A
It is the major component of a family of cyclic lipopeptides produced by pseudomonas fluorescens pf-5. It is a moderate antifungal agent. It has a profound effect on the swarming motility of bacteria on agar surfaces. Synonyms: N-(3-hydroxy-1-oxotetradecyl)-L-leucyl-D-α-glutamyl-D-allothreonyl-D-alloisoleucyl-L-leucyl-D-seryl-L-leucyl-L-leucyl-D-seryl-L-valine, (10→3)-lactone. Grade: >98% by HPLC. CAS No. 939960-34-6. Molecular formula: C64H114N10O17. Mole weight: 1295.65.
Orfamide B
It is a component of a family of cyclic lipopeptides produced by pseudomonas fluorescens pf-5. Synonyms: N-(3-hydroxy-1-oxotetradecyl)-L-leucyl-D-α-glutamyl-D-allothreonyl-D-valyl-L-leucyl-D-seryl-L-leucyl-L-leucyl-D-seryl-L-valine, (10→3)-lactone. Grade: >98% by HPLC. CAS No. 939960-35-7. Molecular formula: C63H112N10O17. Mole weight: 1281.62.
Orforglipron
Treat type 2 diabetes mellitus and, in some cases, obesity. Alternative Names: LY3502970 (Orforglipron);3-((1S,2S)-1-(5-((S)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-2-((S)-3-(3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-indol-1-yl)-2-methylcyclopropyl)-1,2,4-oxadiazol-5(4H)-one;OWL 833. CAS No. 2212020-52-3. Product ID: API2212020523. Molecular formula: C48H48F2N10O5. Mole weight: 882.97. Application: Diabetes. Category: Hypoglycemic APIs.
Orforglipron
Orforglipron (LY3502970) (Compound 67) is an orally active agonist for Glucagon-like peptide-1 receptor ( GLP-1R ), which exhibits potency in ameliorates the type 2 diabete [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY3502970; GLP-1 receptor agonist 1. CAS No. 2212020-52-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-112185.
Orforglipron hemicalcium hydrate
Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate) is the calcium salt hydrate form of Orforglipron (HY-112185). Orforglipron is an orally active agonist for Glucagon-like peptide-1 receptor (GLP-1R), which exhibits potency in ameliorating the type 2 diabete[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate. CAS No. 3008544-96-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112185A.
Org 12962 hydrochloride
Org 12962 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 210821-63-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Org 20599
Hoechst 33342 is a cell-permeable fluorescent DNA stain. It binds minor groove of AT-rich regions and is used to quantify DNA in viable cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 156685-94-8. Pack Sizes: 10mg, 50mg. Molecular Formula: C25H40ClNO3, Molecular Weight: 438.04. US Biological Life Sciences.
Worldwide
Org 24598 lithium salt
Org 24598 lithium salt. Group: Biochemicals. Grades: Purified. CAS No. 722456-08-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Org 25543 hydrochloride
Org 25543 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 495076-64-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Org 25543 hydrochloride
Org 25543 hydrochloride is a selective and irreversible GlyT2 inhibitor ( IC 50 : 16 nM). Org 25543 hydrochloride has analgesia effect. Org 25543 hydrochloride ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 495076-64-7. Pack Sizes: 5 mg. Product ID: HY-107527.
Org-26576
Org-26576 is a positive allosteric modulator of AMPA receptor. Org-26576 increases the anteroventral and laterodorsal thalamus, cingulate cortex, dentate gyrus and CA3 subfield of the hippocampus in mice. Org-26576 is potentially used for the treatment of depression and attention deficit disorder. Uses: Potential treatment of depression and attention deficit disorder. Synonyms: Org26576; Org 26576. CAS No. 1026791-61-6. Molecular formula: C11H12N2O2. Mole weight: 204.229.
Org 27569
Org 27569 is a potent CB1 receptor allosteric modulator, which increases agonist binding, yet blocks agonist-induced CB1 signaling. Uses: Scientific research. Group: Signaling pathways. CAS No. 868273-06-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13288.