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| Product | Description | |
|---|---|---|
| RWJ 52353 | RWJ 52353. Group: Biochemicals. Grades: Purified. CAS No. 245744-10-9. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| RWJ 52353 | RWJ 52353 is an α2 agonist with analgesic activity (Ki= 1.5, 254, 443 and 621 nM for α2D, α2A, α1 and α2B adrenergic receptors respectively). Synonyms: RWJ 52353; RWJ52353; RWJ-52353; 5-(6,7-Dihydrobenzo[b]thien-4-yl-1H-imidazole hydrochloride. Grades: ≥98% by HPLC. CAS No. 245744-10-9. Molecular formula: C11H10N2S. Mole weight: 202.28. |  |
| RWJ 52353 hydrochloride | RWJ 52353 is an agonist of α2D-adrenergic receptors (α2D-ARs) with Ki value of 1.5 nM. It also exhibits agonist activity against α2A-, α2B-, and α1-ARs with Ki values of 254, 621, and 443 nM, respectively. Synonyms: 5-(6,7-dihydro-1-benzothiophen-4-yl)-1H-imidazole hydrochloride. Grades: ≥98%. CAS No. 245744-13-2. Molecular formula: C11H10N2S·HCl. Mole weight: 238.7. | |
| RWJ 56110 | RWJ 56110 is a selective Thrombin R protease-activated receptor (PAR)-1 antagonist which exhibits no activity at PAR2, PAR3, or PAR4 subtypes. It blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Synonyms: (α S)-N-[ (1S)-3-Amino-1-[[ (phenylmethyl)amino]carbonyl]propyl]-α -[[[[1-[ (2, 6-dichlorophenyl)methyl]-3- (1-pyrrolidinylmethyl)-1H-indol-6-yl]amino]carbonyl]amino]-3, 4-difluoro-benzenepropanamide; RWJ-56110; RWJ 56110; RWJ56110. Grades: ≥96% by HPLC. CAS No. 252889-88-6. Molecular formula: C41H43Cl2F2N7O3.2HCl. Mole weight: 863.65. | |
| RWJ 56110 | RWJ 56110. Group: Biochemicals. Grades: Purified. CAS No. 252889-88-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| RWJ 67657 | RWJ 67657 is an orally active inhibitor of the MAP kinases p38alpha and p38beta (IC50s = 1 and 11 uM, respectively, in vitro) that is inactive against p38gamma and p38delta, as well as several other kinases. It blocks the release of TNF-alpha and IL-1beta from peripheral blood mononuclear cells stimulated with LPS (IC50s = 3 and 11 nM, respectively) and inhibits TNF-alpha production in LPS-treated mice and rats. RWJ 67657 potently blocks the proliferation of CD4+ peripheral blood T cells induced by CD28 stimulation alone (IC50 = 0.5-4nM). It is commonly used to study the roles of p38alpha and p38beta in cellular and whole animal systems. Group: Biochemicals. Alternative Names: 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol; 4-(4-Fluorophenyl)-2-(4-hydroxy-1-butynyl)-1-(3-phenylpropyl)-5-(4-Pyridyl)imidazole; JNJ 3026582; RWJ 67657. Grades: Highly Purified. CAS No. 215303-72-3. Pack Sizes: 1mg, 5mg, 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| RWJ-67657 | RWJ-67657 is a p38 mitogen-activated protein-kinase (p38MAPK) inhibitor. RWJ 67657 has been shown to inhibit chemokine production and E-selectin expression in activated endothelial cells. Synonyms: RWJ 67657; RWJ67657; 3-Butyn-1-ol, 4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl)-. Grades: 98%. CAS No. 215303-72-3. Molecular formula: C27H24FN3O. Mole weight: 425.51. | |
| RX-3117 | RX-3117 (TV-1360) is a potent and orally active anticancer and antimetabolite agent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TV-1360; Fluorocyclopentenylcytosine. CAS No. 865838-26-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-15228. |  |
| RX-3117 | RX-3117, also known as TV-1360 and fluorocyclopentenylcytosine, is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity. Upon administration, the cytidine analogue RX-3117 is taken up by cells through a carrier-mediated transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated to its diphosphate (RX-DP) and triphosphate forms (RX-TP). The triphosphate form is incorporated into RNA and inhibits RNA synthesis. The diphosphate RX-DP is reduced by ribonucleotide reductase (RR) to dRX-DP; its triphosphate form (dRX-TP) is incorporated into DNA. In addition, RX-3117 also inhibits DNA methyltransferase 1 (DNMT1). This eventually leads to cell cycle arrest and the induction of apoptosis. UCK is the rate-limiting enzyme in the pyrimidine-nucleotide salvage pathway. Synonyms: RX3117; RX 3117; TV-1360; TV1360; TV 1360; fluorocyclopentenylcytosine. Grades: >98%. CAS No. 865838-26-2. Molecular formula: C10H12FN3O4. Mole weight: 257.221. | |
| RX 821002 hydrochloride | solid, ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| RX 821002 hydrochloride | RX 821002 hydrochloride is a selective and potent α2-adrenoceptor antagonist, which exhibits selectivity for the α2D over the α2A subtypes (pKd= 9.7 and 8.2 respectively). Synonyms: RX821002 hydrochloride; RX-821002 hydrochloride; 2-(2,3-Dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride; 1H-Imidazole, 2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-, hydrochloride (1:1); 1H-Imidazole, 2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-, monohydrochloride; 2-(2-Methoxy-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride; 2-Methoxyidazoxan monohydrochloride. Grades: ≥99% by HPLC. CAS No. 109544-45-8. Molecular formula: C12H14N2O3.HCl. Mole weight: 270.72. | |
| RX 821002 hydrochloride | RX 821002 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 109544-45-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| RX871024 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| RXFP1 Agonist (2-Isopropoxy-N- (2- (3- (trifluoro methyl sulfonyl) phenylcarbamoyl) phenyl) benzamide, LGR7 Agonist, Relaxin/Insulin-like Family Peptide Receptor 1 Agonist, Leucine-Rich Repeat-Containing GPCR 7 Agonist) | A cell-permeable 2-acetamido-N-phenylbenzamide that selectively activates human, but not mouse, LGR7/RXFP1-mediated cAMP induction (EC50 = 200nM in THP1) via allosteric interaction with the ECL3 region without competing against ECL2-mediated relaxin binding or affecting AVPR1B- or LGR8/RXFP2-mediated cAMP induction. Although shown to be ~150-fold and 500-fold less potent than relaxin (RLX), respectively, in VEGF mRNA induction and cellular impedance assays, pharmacokinetic studies reveal superior in vivo stability to RLX and in vivo bioavailability in mice via oral (Cmax/Tmax = 604nM/plasma/1h and 1026ng/g heart/1.5h; 30mg/kg) or intraperitoneal (Cmax/Tmax = 9.29uM/plasma/1h and 28.6uMol/kg heart/1h; 30mg/kg) administration with good aqueous solubility (7uM in PBS). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| RXR?, ligand binding domain, (200-462), GST tagged human | recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| RY785 | RY785 is a selective inhibitor of Kv2.1 voltage-gated potassium channels (IC50 = 0.05 μM) that does not affect Cav2 calcium channels. Uses: Designed for use in research and industrial production. Additional or Alternative Names: RY785; RY-785; RY 785. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1393748-80-5. Molecular formula: C21H20N4O2S. Mole weight: 392.48. Purity: >98%. IUPACName: 3-methoxy-α-methyl-N-[2-(4-thiazolyl)-1H-benzimidazol-6-yl]-benzenepropanamide. Canonical SMILES: O=C(NC1=CC=C2N=C(C3=CSC=N3)NC2=C1)C(C)CC4=CC=CC(OC)=C4. Product ID: ACM1393748805. Alfa Chemistry ISO 9001:2015 Certified. |  |
| RY785 | RY785 is a selective inhibitor of voltage-gated potassium channels with preference for Kv2.1 (IC50 = 0.05 μM). Synonyms: HY-114608; CS-0063544; 3-(3-methoxyphenyl)-2-methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-yl)propanamide hydrochloride. Grades: ≥98%. CAS No. 1393748-80-5. Molecular formula: C21H20N4O2S. Mole weight: 392.5. | |
| Ryanodine | Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca 2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa. Uses: Scientific research. Group: Natural products. CAS No. 15662-33-6. Pack Sizes: 1 mg. Product ID: HY-103306. | |
| Ryanodine | Ryanodine. Group: Biochemicals. Grades: Purified. CAS No. 15662-33-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Rye Flour | certified Reference Material. Group: Food matrix crmsprocess materials, geological, cement & soils. | |
| Rye Grass | certified Reference Material. Group: Food matrix crms. | |
| RyR-Calstabin Interaction Stabilizer, S107 (7-methoxy-4-methyl-2, 3, 4, 5-tetrahydrobenzo[f][1, 4]thiazepine, Ryanodine Receptor Stabilizer; Rycal S107) | A cell-permeable, orally active benzothiazepine that effectively blocks leaky intracellular calcium release by preventing the dissociation/depletion of calstabin from the ryanodine receptor (RyR) complex due to receptor modifications, such as oxidation, S-nitrosylation, hyperphosphorylation, or mutation (complete blockage of 1 mM tetracaine-induced leakage in murine RyR2 S2808D+/+ myocytes at 1uM). Shown to prevent stress-induced cognitive dysfunction by stabilizing RyR2-calstabin-2 (FKBP12.6) interaction in brain (75mg/kg/day; p.o.) and maintain exercise capacity by stabilizing RyR1-calstabin-1 (FKBP12) interaction in skeletal muscle (2. 5ug/0. 25uL/h/animal; s.c) in mice, as well as restore normal cardiac function (20mg/kg/day; s.c) in mice with R2474S or S2808D RyR2 mutation in vivo.Primary Target:RyR2. Group: Biochemicals. Alternative Names: 7-methoxy-4-methyl-2, 3, 4, 5-tetrahydrobenzo[f][1, 4]thiazepine, Ryanodine Receptor Stabilizer; Rycal S107. Grades: Highly Purified. CAS No. 927871-76-9. Pack Sizes: 10mg. Molecular Formula: C??H??NOS, Molecular Weight: 209.3. US Biological Life Sciences. | Worldwide |
| Ryuvidine | Ryuvidine. Group: Biochemicals. Grades: Purified. CAS No. 265312-55-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ryuvidine | Ryuvidine, a cell-permeable dioxobenzothiazole compound, is an inhibitor of SETD8 (IC50 = 0.5 μM) that suppresses monomethylation of H4K20 in vitro.1 It less potently inhibits cyclin-dependent kinase 4 (Cdk4; IC50 = 6 μM for Cdk4/cyclin D1). Synonyms: 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione; Cdk4 Inhibitor III; Cyclic-dependent Kinase 4 Inhibitor III; Ryuvidine; SPS8I2; SPS-8I2; SPS 8I2. Grades: ≥98% by HPLC. CAS No. 265312-55-8. Molecular formula: C15H12N2O2S. Mole weight: 284.33. | |
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