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| Product | Description | |
|---|---|---|
| RyR-Calstabin Interaction Stabilizer, S107 (7-methoxy-4-methyl-2, 3, 4, 5-tetrahydrobenzo[f][1, 4]thiazepine, Ryanodine Receptor Stabilizer; Rycal S107) | A cell-permeable, orally active benzothiazepine that effectively blocks leaky intracellular calcium release by preventing the dissociation/depletion of calstabin from the ryanodine receptor (RyR) complex due to receptor modifications, such as oxidation, S-nitrosylation, hyperphosphorylation, or mutation (complete blockage of 1 mM tetracaine-induced leakage in murine RyR2 S2808D+/+ myocytes at 1uM). Shown to prevent stress-induced cognitive dysfunction by stabilizing RyR2-calstabin-2 (FKBP12.6) interaction in brain (75mg/kg/day; p.o.) and maintain exercise capacity by stabilizing RyR1-calstabin-1 (FKBP12) interaction in skeletal muscle (2. 5ug/0. 25uL/h/animal; s.c) in mice, as well as restore normal cardiac function (20mg/kg/day; s.c) in mice with R2474S or S2808D RyR2 mutation in vivo.Primary Target:RyR2. Group: Biochemicals. Alternative Names: 7-methoxy-4-methyl-2, 3, 4, 5-tetrahydrobenzo[f][1, 4]thiazepine, Ryanodine Receptor Stabilizer; Rycal S107. Grades: Highly Purified. CAS No. 927871-76-9. Pack Sizes: 10mg. Molecular Formula: C??H??NOS, Molecular Weight: 209.3. US Biological Life Sciences. |  Worldwide |
| Ryuvidine | Ryuvidine, a cell-permeable dioxobenzothiazole compound, is an inhibitor of SETD8 (IC50 = 0.5 μM) that suppresses monomethylation of H4K20 in vitro.1 It less potently inhibits cyclin-dependent kinase 4 (Cdk4; IC50 = 6 μM for Cdk4/cyclin D1). Synonyms: 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione; Cdk4 Inhibitor III; Cyclic-dependent Kinase 4 Inhibitor III; Ryuvidine; SPS8I2; SPS-8I2; SPS 8I2. Grades: ≥98% by HPLC. CAS No. 265312-55-8. Molecular formula: C15H12N2O2S. Mole weight: 284.33. |  |
| Ryuvidine | Ryuvidine. Group: Biochemicals. Grades: Purified. CAS No. 265312-55-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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