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| Product | Description | |
|---|---|---|
| SRI-37330 hydrochloride | SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2322245-49-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-141623. |  |
| SRI-41315 | SRI-41315 induces a prolonged pause at stop codons and suppresses PTCs (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613509-49-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150090. | |
| SRI-42127 | SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2727872-68-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148853. | |
| S-ribosylhomocysteine lyase | Contains Fe2+. The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density. Group: Enzymes. Synonyms: S-ribosylhomocysteinase; LuxS. Enzyme Commission Number: EC 4.4.1.21. CAS No. 37288-63-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5323; S-ribosylhomocysteine lyase; EC 4.4.1.21; 37288-63-4; S-ribosylhomocysteinase; LuxS. Cat No: EXWM-5323. |  |
| S, R-Isovalganciclovir Impurity | S, R-Isovalganciclovir Impurity is an impurity of Valganciclovir. Synonyms: (R,S)-Iso Valganciclovir; (R)-[(S)-3-[(2-Amino-6-oxo-1,6-dihydropurin-9-yl)methoxy)-2-hydroxypropyl)-2,3-dimethylbutanoate. Grades: > 95%. CAS No. 1356932-18-7. Molecular formula: C14H22N6O5. Mole weight: 354.36. |  |
| SRMS, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. |  |
| S- (+)-Rolipram | S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer. Synonyms: (S)-(+)-rolipram; 85416-73-5; S-(+)-Rolipram(S)-ROLIPRAMS- (+)-Rolipram. Grades: >98%. CAS No. 85416-73-5. Molecular formula: C16H21NO3. Mole weight: 275.34. | |
| Srpin340 | Srpin340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 μM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. Srpin340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells. Synonyms: SRPIN-340; SRPIN 340. Grades: 99.82%. CAS No. 218156-96-8. Molecular formula: C18H18F3N3O. Mole weight: 349.35. | |
| SRPIN340 | SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 ?M for SRPK1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SRPK inhibitor. CAS No. 218156-96-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13949. | |
| SRPIN340 | SRPIN340. Group: Biochemicals. Grades: Purified. CAS No. 218156-96-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| SRPIN340 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SRPK1, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| SRPKIN-1 | SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2089226-94-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-116856. | |
| SRPK Inhibitor, SRPIN340 (N- (2-Piperidin-1-yl-5- (trifluoromethyl) phenyl) isonicotinamide, Serine-Arginine-Rich Protein Kinase Inhibitor, SR Protein Kinase Inhibitor, SR Protein Phosphorylation Inhibitor 340, (SRPIN)340) | A cell-permeable isonicotinamide that acts as an ATP-competitive SRPK1-selective inhibitor (IC50 = 0.14 and 1.8uM, respectively, against mSRPK1 and mSRPK2) with much reduced activity against 143 other kinases. Shown to effectively counteract IGF-1-induced anti-angiogenic to pro-angiogenic VEGF isoforms switch both in cultures in vitro (1h 10uM SRPIN340 prior to 12h IGF-1 stimulation of PCIPs) and in a murine hypoxia-induced retinal neovascularization model in vivo (10pmol/uL/eye intraocular SRPIN340 injection) by inhibiting PKC/SRPK signaling-dependent, alternate splicing factor ASF- (SF2; splicing factor 2) mediated VEGF pro-mRNA PSS (proximal splice site) selection. Suppresses RNA virus Sindbis propagation (IC50 = 60uM in Vero cultures) and HCV-JFH1 replication (1 & 10uM SRPIN340 in Huh7.5.1 cultures). Exhibits no toxicity toward rats (2g/kg p.o. for 2 wks), CHO (5mg/ml for 24h), or Huh7 (30uM for 48h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SRS11-92 | SRS11-92 is an effective iron death inhibitor. It inhibits Erastin-induced iron death cells in HT-1080 human fibrosarcoma cells (EC50=6 nM). Synonyms: 4-(Cyclohexylamino)-3-[(Phenylmethyl)Amino]-Benzoic acid, Ethylester. Grades: 98%. CAS No. 1467047-25-1. Molecular formula: C22H28N2O2. Mole weight: 352.5. | |
| SRT1720 | SRT1720 is a drug developed by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. It has similar activity in the body to the known SIRT1 activator resveratrol, but is 1000x more potent. In animal studies it was found to improve insulin sensitivity and lower plasma glucose levels in fat, muscle and liver tissue, and increased mitochondrial and metabolic function. Although SRT1720 is not currently undergoing clinical development, a related compound, SRT2104, is currently in clinical development for metabolic diseases. Synonyms: 2-Quinoxalinecarboxamide, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-; N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide; SRT 1720; SRT-1720. Grades: ≥95%. CAS No. 925434-55-5. Molecular formula: C25H23N7OS. Mole weight: 469.56. | |
| SRT1720 | SRT1720 Inhibitor. Uses: Scientific use. Product Category: T2412. CAS No. 1001645-58-4. |  |
| SRT 1720 | SRT 1720 is a selective activator of human SIRT1 with an EC 1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC 1.5 s of 37 μM and > 300 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 925434-55-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10532. | |
| SRT1720 - CAS 925434-55-5 | SRT1720, CAS 925434-55-5, is a cell-permeable inhibitor of the mitochondrial SIRT3. Inhibition is AceCS2-competitive (Ki = 0.56 μM; Km = 2.44 μM), but NAD+-uncompetitive (Ki = 0.34 μM; Km = 280 μM). Group: Fluorescence/luminescence spectroscopy. | |
| SRT 1720 dihydrochloride | SRT 1720 dihydrochloride is a selective and orally active activator of SIRT1 with an EC 50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2468639-77-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15145A. | |
| SRT1720 hydrochloride | SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM, but is >230-fold less potent for SIRT2 and SIRT3. Synonyms: SRT1720 HCl; SRT1720; N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide hydrochloride. Grades: >98%. CAS No. 1001645-58-4. Molecular formula: C25H23N7OS.HCl. Mole weight: 506.02. | |
| SRT1720 Hydrochloride | SRT1720 Hydrochloride. Group: Biochemicals. Alternative Names: N-[2-[3- (1-piperazinylmethyl) imidazo[2, 1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Hydrochloride. Grades: Highly Purified. CAS No. 1001645-58-4. Pack Sizes: 5mg. Molecular Formula: C25H23N7OS xHCl, Molecular Weight: 469.56. US Biological Life Sciences. | Worldwide |
| SRT 2104 | SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntingtons disease[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1093403-33-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15262. | |
| SRT2104 (GSK2245840) | SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2. Synonyms: SRT2104; SRT 2104; SRT-2104; GSK2245840; GSK-2245840; GSK 2245840. Grades: >98%. CAS No. 1093403-33-8. Molecular formula: C26H24N6O2S2. Mole weight: 516.64. | |
| SRT2183 | SRT2183 is a Sirt1 activator, currently being developed by Sirtris Pharmaceuticals. SRT2183 has similar activity in the body to another SIRT1 activator SRT1720, but is closer in potency to resveratrol. In animal studies it was found to improve insulin sensitivity and lower plasma glucose levels in fat, muscle and liver tissue, and increased mitochondrial and metabolic function. Synonyms: SRT 2183; SRT-2183; (R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)methyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthamide. Grades: 98%. CAS No. 1001908-89-9. Molecular formula: C27H24N4O2S. Mole weight: 468.575. | |
| SRT3025 HCl | SRT3025 HCl is the hydrochloride form of SRT3025, an agonist of Sirt1. In Fanconi anemia mice, SRT3025 expands hematopoietic stem and progenitor cells as well as improves hematopoiesis; In Apoe-/- mice, SRT3025 decreases plasma cholesterol, inflammation, atherosclerosis, and also increases hepatic Ldlr expression and Pcsk9 accumulation; SRT3025 suppresses the growth of Panc-1 xenografts. Synonyms: SRT3025 HCl; SRT 3025 HCl; SRT-3025 HCl. Grades: 99.62 %. CAS No. 2070015-26-6. Molecular formula: C31H31N5O2S2.HCl. Mole weight: 606.2. | |
| SRT3109 | SRT3109 is a CXCR2 ligand. Synonyms: SRT3109; SRT-3109; SRT 3109. N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-[[(1R,2R)-2,3-dihydroxy-1-methylpropyl]amino]-4-pyrimidinyl]-1-azetidinesulfonamide; SCHEMBL3180319; ABP000357; ZINC68197865; CS-0977; RL-00854; HY-15462; DB-061750; KB-298382; CS 0977; RL 00854; HY 15462; DB 061750; KB 298382; CS0977; RL00854; HY15462; DB061750; KB298382. CAS No. 1204707-71-0. Molecular formula: C18H23F2N5O4S2. Mole weight: 475.53. | |
| SRT3190 | SRT3190 is a CXCR2 ligand. Synonyms: SRT3190; SRT-3190; SRT 3190. SCHEMBL3171248; QVKPEMXUBULFBM-FZMZJTMJSA-N ; 4065AH; ZINC95641942; CS-0265; HY-13021; KB-80727; W-5813; CS 0265; HY 13021; KB 80727; W 5813; CS0265; HY13021; KB80727; W5813; N-(2-((2,3-Difluorobenzyl)thio)-6-(((2S,3R)-3,4-dihydroxybutan-2-yl)amino)pyrimidin-4-yl)azetidine-1-sulfonamide. CAS No. 1204707-73-2. Molecular formula: C18H23F2N5O4S2. Mole weight: 475.53. | |
| S,S?-[1,4-Phenylenebis(2,1-ethynediyl-4,1-phenylene)]bis(thioacetate) | 97% (HPLC). Group: Self assembly and lithography. | |
| SS-208 | SS-208 is a selective HDAC6 inhibitor, with an IC 50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AVS100. CAS No. 2245942-72-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126330. | |
| SS-228Y | SS-228Y is an antibiotic produced by Chainia Sp. It is active against gram-positive bacteria and Ehrlich's ascites carcinoma. Synonyms: Antibiotic SS-228 Y; SS-228 Y. Grades: 95%. CAS No. 56257-16-0. Molecular formula: C19H14O6. Mole weight: 338.31. | |
| SS5020 | SS5020 is a novel benzopyran antiestrogen and it exhibits no genotoxic activity to damage DNA. In addiction, SS5020 does not present significant uterotrophic potential in rats. SS5020 had stronger antitumor potential than those same antiestrogens against 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats when using the human equivalent molar dose of TAM. Uses: Antitumor activity. Synonyms: SS5020; SS5020; SS 5020. (E)-3-(4-((7-hydroxy-2-oxo-3-phenyl-2H-chromen-4-yl)methyl)phenyl)acrylic acid. Grades: 98%. CAS No. 1334310-70-1. Molecular formula: C25H18O5. Mole weight: 398.41. | |
| SS-56C | SS-56C is an aminoglycoside antibiotic produced by Streptomyces eurocidicus. It exhibits activity against gram-positive and gram-negative bacteria. Synonyms: SS-56 C. CAS No. 39471-55-1. Molecular formula: C19H35N3O14. Mole weight: 529.5. | |
| SS-56D | SS-56D is an aminoglycoside antibiotic produced by Streptomyces eurocidicus. It exhibits activity against gram-positive and gram-negative bacteria. Synonyms: SS-56 D. Molecular formula: C19H35N3O13. Mole weight: 513.49. | |
| SSA protein SS-56 (55-64) | A peptide fragment of SSA protein SS-56. | |
| S,S-Atorvastatin | . Uses: Anticholesteremic agents; hydroxymethylglutaryl-coa reductase inhibitors. Synonyms: (1betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid; 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-, (R*,R*)-. CAS No. 110862-48-1. Molecular formula: C33H35FN2O5. Mole weight: 558.65. | |
| S,S'-BIS-(2-THIENYL)-METHYLENE-DISULPHIDE | S,S'-BIS-(2-THIENYL)-METHYLENE-DISULPHIDE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: S,S'-BIS-(2-THIENYL)-METHYLENE-DISULPHIDE. Product Category: Heterocyclic Organic Compound. CAS No. 119784-44-0. Molecular formula: C9H8S4. Mole weight: 244.42. Product ID: ACM119784440. Alfa Chemistry ISO 9001:2015 Certified. |  |
| SSBR | SSBR. Group: Polymers. |  |
| S(?)-SCH-23388, Des-chloro hydrochloride | analytical standard. Group: Additional drugs. | |
| S(?)-SCH-23388, Iodo analog hydrochloride | analytical standard, solid. Group: Additional drugs. | |
| S-Scoulerine | S-Scoulerine. Group: Biochemicals. Alternative Names: 5, 8, 13, 13a-Tetrahydro-3, 10-dimethoxy-6H-dibenzo[a, g]quinolizine-2, 9-diol; (+/-)-3,10-Dimethoxy-berbine-2,9-diol; (RS)-scoulerine. Grades: Highly Purified. CAS No. 6451-73-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C19H21NO4. US Biological Life Sciences. | Worldwide |
| S,S'-Diethyl Dithiocarbonate | S,S'-Diethyl Dithiocarbonate. Group: Biochemicals. Alternative Names: Dithiocarbonic Acid S,S'-Diethyl Ester. Grades: Highly Purified. CAS No. 623-80-3. Pack Sizes: 1g, 2g, 5g, 10g, 25g. US Biological Life Sciences. | Worldwide |
| s,s'-Diethyl N,N'-hexane-1,6-diylbis(dibutylethylammonium)disulfate | s,s'-Diethyl N,N'-hexane-1,6-diylbis(dibutylethylammonium)disulfate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Tetrabutyldiethylhexamethylenediammonium ethylsulfate. Product Category: Heterocyclic Organic Compound. CAS No. 68052-49-3. Molecular formula: C26H58N2.2C2H5O4S. Mole weight: 648.999520 [g/mol]. Purity: 0.96. IUPACName: dibutyl-[6-[dibutyl(ethyl)azaniumyl]hexyl]-ethylazanium; ethyl sulfate. Canonical SMILES: CCCC[N+](CC)(CCCC)CCCCCC[N+](CC)(CCCC)CCCC.CCOS(=O)(=O)[O-].CCOS(=O)(=O)[O-]. ECNumber: 268-327-3. Product ID: ACM68052493. Alfa Chemistry ISO 9001:2015 Certified. | |
| S,S'-dimethyl dithiocarbonate | S,S'-dimethyl dithiocarbonate. Group: Biochemicals. Grades: Highly Purified. CAS No. 868-84-8. Pack Sizes: 500g, 1kg. Molecular Formula: C3H6OS2. US Biological Life Sciences. | Worldwide |
| S,S-Diphenylsulfilimine Monohydrate | S,S-Diphenylsulfilimine Monohydrate. Group: Biochemicals. Grades: Highly Purified. CAS No. 68837-61-6. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. US Biological Life Sciences. | Worldwide |
| SSE15206 | SSE15206 is a tubulin polymerization inhibitor that overcomes multidrug resistance. It exhibits potent antiproliferative activities in cancer cell lines. Synonyms: HY-111425; SSE-15206; SSE 15206; 5-Phenyl-3-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrazole-2-carbothioamide. CAS No. 1370046-40-4. Molecular formula: C19H21N3O3S. Mole weight: 371.45. | |
| Sse9 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of pBR322 DNA in 1 hour at 55°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme more than 95% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 500 U; 2500U. ↑AATT TTAA&darr. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer B, BSA. Storage: -20°C. Form: Liquid. Source: An E.coli strain that carries the cloned Sse9 I gene from Sporosarcina species. Pack: 10 mM Tis-HCl (pH 7.5); 50 mM NaCl; 0.1 mM EDTA; 1 mM DTT; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1180RE. | |
| SSEA-4 hexaose | SSEA-4 Hexaose is an extraordinary compound origining from the SSEA-4 antigen, used for studying diverse ailments, encompassing the realms of cancer to neurodegenerative disorders. Synonyms: Neu5Aca2-3Galb1-3GalNAcb1-3Gala1-4Galb1-4Glc; Stage-Specific Embryonic Antigen-4. Molecular formula: C43H71N2O34Na. Mole weight: 1183.01. | |
| S, S'-Ethylenebis (glutathione) | S, S'-Ethylenebis (glutathione) is a haloethane-glutathione conjugate formed via GSH transferases. S, S'-Ethylenebis (glutathione) formation is used to study the polymorphism in glutathione conjugation activity of human erythrocytes towards ethylene dibromide. Group: Biochemicals. Alternative Names: 2,2'-(1,2-Ethanediyl)bis[L-γ-glutamyl-L-cysteinylglycine. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| SSI-4 | SSI-4 is an inhibitor of Stearoyl CoA desaturase 1 (SCD1) , which can be modified with 11 C, used as a ligand to in vivo small animal PET/CT imaging of SCD1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1875084-68-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155033. | |
| S, S-Isovalganciclovir Impurity | S, S-Isovalganciclovir Impurity is an impurity of Valganciclovir. Synonyms: (S,S)-Iso Valganciclovir Hydrochloride; (2S)-3-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-L-valine 2-Hydroxypropyl Ester Hydrochloride. Grades: > 95%. CAS No. 1401562-13-7. Molecular formula: C14H23N6O5Cl. Mole weight: 390.83. | |
| SSK1 | SSK1, a senescence-specific killing compound, is a ?-galactosidase-targeted proagent attenuates inflammation. SSK1 is activated by lysosomal ?-galactosidase and selectively killed senescent cells through the activation of p38 MAPK and induction of apoptosis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2629250-69-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138936. | |
| S-(?)-SKF-38393 hydrochloride | solid. Group: Fluorescence/luminescence spectroscopy. | |
| SSM 3 trifluoroacetate | SSM 3 trifluoroacetate is a potent furin inhibitor (EC50 = 54 nM) which blocks furin-dependent cell surface processing of anthrax protective antigen-83 in vitro. Synonyms: SSM 3 trifluoroacetate; SSM3 trifluoroacetate; SSM-3 trifluoroacetate; SSM3 TFA; SSM-3 TFA; SSM 3 TFA; SSM3 TFA salt; rel-N,N''-[[(1R,3S,4S,6R)-4,6-Bis[(aminoiminomethyl)amino]-1,3-cyclohexanedyil]bis(oxy-4,1-phenylene)]bisguanidine tetratrifluoroacetate salt. Grades: ≥98% by HPLC. CAS No. 922732-52-3. Molecular formula: C22H32N12O2.4CF3CO2H. Mole weight: 952.66. | |
| Ssp I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 10-fold overdigestion with enzyme 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 500 U; 2500U. AAT↑ATT TTA↓TAA. Activity: 10000u.a./ml. Appearance: 10 X SE-buffer K, BSA. Storage: -20°C. Form: Liquid. Source: An E.coli strain, that carries the cloned gene SspI from Sphaerotilus species. Pack: 10 mM Tris-HCl (pH 7.5); 200 mM NaCl; 0,1 mM EDTA; 1 mM DTT; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1181RE. | |
| SSR125543 | SSR125543 is a selective corticotropin-releasing factor 1 receptor (CRF1) antagonist with pKi value of 9.08 for native CRF1 receptor. It can prevent stress-induced cognitive deficit associated with hippocampal dysfunction. In Apr 2011, Phase-II for Major depressive disorder was discontinued. Uses: Major depressive disorder. Synonyms: SSR125543; SSR 125543; SSR-125543; SSR 125543A;321839-75-2(hydrochloride);(S)-4-(2-chloro-4-methoxy-5-methylphenyl)-N-(2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl)-5-methyl-N-(prop-2-yn-1-yl)thiazol-2-amine. Grades: 98%. CAS No. 752253-39-7. Molecular formula: C27H28ClFN2OS. Mole weight: 483.04. | |
| SSR 125543A | SSR 125543A is a potent and orally bioactive corticotropin-releasing factor 1 receptor (CRF1) antagonist (pKi values of 8.73 and 9.08 for human cloned or native CRF1 receptors, respectively) with 1000-fold selectivity for CRF1 over CRF2α receptor and CRF binding protein. SSR 125543A exhibited antidepressant and anxiolytic properties in the Flinders Sensitive Line rats. Synonyms: SR-125543A; SR125543A; LS-150601; LS150601; LS 150601; 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine hydrochloride. Grades: 98%. CAS No. 321839-75-2. Molecular formula: C27H28ClFN2OS.HCl. Mole weight: 519.5. | |
| SSR128129E | SSR128129E (SSR) is an potent FGFR inhibitor, which inhibits fibroblast growth factor receptor (FGFR) signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. SSR128129E exhibits allosteric properties, including probe dependence, signaling bias, and ceiling effects. Oral delivery of SSR128129E inhibits arthritis and tumors that are relatively refractory to anti-vascular endothelial growth factor receptor-2 antibodies. Thus, orally-active extracellularly acting small-molecule modulators of RTKs with allosteric properties can be developed and may offer opportunities to improve anticancer treatment. Synonyms: SSR128129E; SSR 128129E; SSR-128129E. Grades: 0.98. CAS No. 848318-25-2. Molecular formula: C18H15N2NaO4. Mole weight: 346.318. | |
| SSR128129E | SSR128129E is an orally available and allosteric FGFR inhibitor with an IC 50 of 1.9 μM for FGFR1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SSR. CAS No. 848318-25-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15599. | |
| SSR128129E free acid | SSR128129E free acid is a multi-FGFR blocker with allosteric properties. It inhibits FGFR signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. Synonyms: SSR free acid. Grades: >98%. CAS No. 848463-13-8. Molecular formula: C18H16N2O4. Mole weight: 324.33. | |
| SSR 146977 hydrochloride | SSR 146977 hydrochloride is a potent and selective NK3 receptor antagonist (Ki = 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor, respectively). SSR 146977 also exhibits an inhibitory effect on senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM). Synonyms: SSR 146977 hydrochloride; SSR146977 hydrochloride; SSR-146977 hydrochloride; N1-[1-3-[(3R)-1-Benzoyl-3-(3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-piperidinyl]-N,N-dimethylurea hydrochloride. Grades: ≥98% by HPLC. CAS No. 264618-38-4. Molecular formula: C35H42Cl2N4O2.HCl. Mole weight: 658.11. | |
| SSR 146977 hydrochloride | SSR 146977 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 264618-38-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SSR 149415 | SSR 149415 is a potent and orally available vasopressin V1B antagonist (Ki = 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively), displaying >70-fold selectively for rat V1B over V1A, V2 oxytoxin and a range of other receptors and ion channels. SSR 149415 has been shown to inhibit stress-induced ACTH release and exhibit anxiolytic-like effects in anxiety models, therefore it is identified as a drug candidate for the treatment of anxiety and depression. Uses: Potential treatment of anxiety and depression. Synonyms: Nelivaptan; SSR149415; SR-149415; SR 149415;; (2S,4R)-1-[(3R)-5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-(2-methoxyphenyl)-2-oxo-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 439687-69-1. Molecular formula: C30H32ClN3O8S. Mole weight: 630.11. | |
| SSR 180711 hydrochloride | SSR 180711 hydrochloride is a partial agonist at α7 nAChR. It enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. SSR 180711 leads to an increase of extracellular dopamine levels in rat prefrontal cortex and also exhibits antidepressant-like properties. Synonyms: SSR 180711 hydrochloride; SSR180711 hydrochloride; SSR-180711 hydrochloride; 4-Bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate hydrochloride. Grades: ≥98% by HPLC. CAS No. 446031-79-4. Molecular formula: C14H17BrN2O2.HCl. Mole weight: 361.66. | |
| SSR180711 hydrochloride | SSR180711 hydrochloride is an orally active, selective and reversible α7 acetylcholine nicotinic receptor (n-AChRs) partial agonist. SSR180711 hydrochloride can act on rat α7 n-AChR ( K i =22 nM; IC 50 =30 nM) and human α7 n-AChR ( K i =14 nM; IC 50 =18 nM). SSR180711 hydrochloride increases glutamatergic neurotransmission, ACh release and long-term potentiation (LTP) in the hippocampus [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 446031-79-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19411. | |
| SSR 240612 hydrochloride | SSR 240612 is a bradykinin B1 receptor inhibitor, displaying selectivity for B1 receptor over B2 receptor with Ki values of 0.48-0.73 and 358-481 nM, respectively. Synonyms: SSR 240612; SSR-240612; SSR240612; SSR 240612 HCl. Grades: ≥95%. CAS No. 464930-42-5. Molecular formula: C42H52N4O7S·HCl. Mole weight: 793.41. | |
| SSR504734 | SSR504734 is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 ( IC 50 =18, 15, and 38?nM, respectively). SSR504734 shows anti-schizophrenia, anti-anxiety and anti-depression activities [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 615571-23-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10715. | |
| SSR 504734 | SSR 504734 is a potent and orally bioactive GlyT-1 inhibitor blocking the ex vivo uptake of glycine reversibly in animal models of schizophrenia, anxiety and depression. Synonyms: D06SBS; SSR 504734; SSR504734; SSR-504734; 2-chloro-N-[(S)-phenyl-[(2S)-piperidin-2-yl]methyl]-3-(trifluoromethyl)benzamide hydrochloride. Grades: 99%. CAS No. 615571-23-8. Molecular formula: C20H20ClF3N2O.HCl. Mole weight: 433.29. | |
| SSR 69071 | SSR 69071. Group: Biochemicals. Grades: Purified. CAS No. 344930-95-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SSR 69071 | SSR 69071 is a potent and high affinity human leukocyte elastase (HLE) inhibitor (IC50 = 3.9 nM) that displays species-selectivity (Ki = 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase, respectively). SSR 69071 has been shown to inhibit HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduce infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Synonyms: SSR 69071; SSR69071; SSR-69071; 2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one. Grades: ≥98% by HPLC. CAS No. 344930-95-6. Molecular formula: C27H32N4O7S. Mole weight: 556.63. | |
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