A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
SR4554 is a fluorine-containing 2-nitroimidazole, designed as a hypoxia marker detectable with 19F magnetic resonance spectroscopy (MRS). SR-4554 has plasma pharmacokinetic and toxicity profiles suitable for use as a hypoxia probe. It can be detected in tumors by unlocalized MRS. Additional clinical studies are warranted. Synonyms: SR-4554; SR 4554; N-(2-Hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl)acetamide. CAS No. 167648-73-9. Molecular formula: C8H9F3N4O4. Mole weight: 282.18.
SR 48692. Group: Biochemicals. Grades: Purified. CAS No. 146362-70-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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SR 49059
SR 49059. Group: Biochemicals. Grades: Purified. CAS No. 150375-75-0. Pack Sizes: 10mg. US Biological Life Sciences.
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SR 49059
SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a K i vaule of 1.4 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 150375-75-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18345.
SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC 50 ) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 77145-61-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-102064.
SR 57227A hydrochloride
SR 57227 hydrochloride is a selective and high affinity 5-HT3 receptor agonist. SR 57227 exhibits anti-depressant like effects and decreases isolation-induced aggressive behavior in rat model. Synonyms: SR 57227A hydrochloride; SR57227A hydrochloride; SR-57227A hydrochloride; 1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride; 4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride. Grades: ≥99% by HPLC. CAS No. 77145-61-0. Molecular formula: C10H14ClN3.HCl. Mole weight: 248.15.
SR 57227 hydrochloride
SR 57227 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 77145-61-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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SR-58611
SR-58611. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (7S)-5,6,7,8-Tetrahydro-7-[[(R)-2-hydroxy-2-(3-chlorophenyl)ethyl]amino]-2-[(ethoxycarbonyl)methoxy]naphthalene;SR-58611;SR-58825A;amibegron. Product Category: Heterocyclic Organic Compound. CAS No. 121524-08-1. Molecular formula: C22H26ClNO4. Purity: 0.96. IUPACName: ethyl 2-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]acetate. Canonical SMILES: CCOC(=O)COC1=CC2=C(CCC(C2)NCC(C3=CC(=CC=C3)Cl)O)C=C1. Product ID: ACM121524081. Alfa Chemistry ISO 9001:2015 Certified. Categories: SR58611A.
SR 59230A hydrochloride is a potent, selective and orally available β3 adrenoceptor antagonist (IC50 = 40, 408 and 648 nM for β3, β1 and β2 receptors, respectively). SR 59230A blocks MDMA-induced hyperthermia at low concentrations, while it blocks hyperthermia and also increases heat loss through an α1-AR antagonistic mechanism at high concentrations. Synonyms: SR 59230A hydrochloride; SR59230A hydrochloride; SR-59230A hydrochloride; 1-(2-Ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol hydrochloride; (2S)-1-(2-ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]propan-2-ol hydrochloride. Grades: ≥98% by HPLC. CAS No. 1135278-41-9. Molecular formula: C21H27NO2.HCl. Mole weight: 361.91.
SR 59230A hydrochloride
SR 59230A hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1135278-41-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 ?M and 2.2 ?M in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2375421-09-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131454.
SR-717 lithium
SR-717 is an agonist of stimulator of interferon genes STING for treating cancer. SR-717 demonstrates broad interspecies and interallelic specificity. SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SR-717 lithium; SR 717 lithium; SR717 lithium. Product Category: Agonists. Appearance: Solid powder. CAS No. 2375421-09-1. Molecular formula: C15H8F2LiN5O3. Mole weight: 351.2. Purity: >98%. IUPACName: lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate. Canonical SMILES: O=C([O-])C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O.[Li+]. Product ID: ACM2375421091. Alfa Chemistry ISO 9001:2015 Certified.
SR-717 lithium
SR-717 is an agonist of stimulator of interferon genes (STING) for treating cancer. Synonyms: SR 717 lithium; SR717 lithium. Grades: >98%. CAS No. 2375421-09-1. Molecular formula: C15H8F2LiN5O3. Mole weight: 351.2.
SR 7826
SR 7826 is a potent and selective LIMK inhibitor (IC50 = 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). SR 7826 was shown to inhibit cofilin phosphorylation in A7r5 cells and suppress migration and invasion of PC-3 cells in vitro. Synonyms: SR7826; SR-7826; SR 7826; N-(2-Hydroxyethyl)-N'-[4,5-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)phenyl]-N-phenylurea; 1-(2-hydroxyethyl)-3-[4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-phenylurea. Grades: ≥98% by HPLC. CAS No. 1219728-20-7. Molecular formula: C22H21N5O2. Mole weight: 387.43.
SR8278
SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC 50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1254944-66-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14415.
SR 8278. Group: Biochemicals. Alternative Names: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 1254944-66-5. Pack Sizes: 10mg. Molecular Formula: C18H19NO3S2, Molecular Weight: 361.48. US Biological Life Sciences.
Worldwide
SR 8278
SR 8278 is a nuclear heme receptor Rev-Erbα antagonist. This compound inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM) and blocks activity of Rev-Erbα agonist GSK 4112 in HEK293 cells. SR 8278 increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells. Synonyms: SR8278; SR 8278; SR-8278. 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester; ethyl 2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate. Grades: ≥99% by HPLC. CAS No. 1254944-66-5. Molecular formula: C18H19NO3S2. Mole weight: 361.48.
SR9009
SR9009 is a REV-ERBα/β agonist with IC 50 s of 670 nM and 800 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1379686-30-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16989.
SR9011
SR9011 is a REV-ERBα / β agonist with IC 50 s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1379686-29-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16988.
SR9011, a synthetic REV-ERB agonist, has been found to have probable effect against sleep disorders and metabolic diseases. IC50: 790 nM and 560 nM for Rev-ErbBα and Rev-ErbBβ respectively. Synonyms: SR 9011; SR-9011; 1-Pyrrolidinecarboxamide, 3-((((4-chlorophenyl)methyl)((5-nitro-2-thienyl)methyl)amino)methyl)-n-pentyl-. Grades: 98%. CAS No. 1379686-29-9. Molecular formula: C23H31ClN4O3S. Mole weight: 479.04.
SR9011 hydrochloride
SR9011 hydrochloride is a REV-ERBα / β agonist with IC 50 s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070014-94-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16988A.
SR 9186
SR 9186 is an inhibitor of the cytochrome P450 isoform CYP3A4 with IC50 value of 0.011 μM. Synonyms: 1-[4-(4-Cyanophenyl)phenyl]-3-[4-(1H-imidazo[4,5-b]pyridin-7-yl)phenyl]urea. Grades: ≥95%. CAS No. 1361414-26-7. Molecular formula: C26H18N6O. Mole weight: 430.5.
SR 9238 is a potent and selective LXR inverse agonist (IC50 = 43 and 214 nM for LXRβ and LXRα, respectively) with selectivity over a panel of 20 other nuclear receptors, including FXR. SR 9238 exhibits little activity at peripheral LXR. SR 9238 has been shown to reduce hepatic steatosis in obese mice. Synonyms: SR9238; SR 9238; SR-9238; Ethyl 5-[[[[3'- (Methylsulfonyl) [1, 1'-biphenyl]-4-yl]methyl][ (2, 4, 6-trimethylphenyl) sulfonyl]amino]methyl]-2-furancarboxylate. Grades: ≥98% by HPLC. CAS No. 1416153-62-2. Molecular formula: C31H33NO7S2. Mole weight: 595.73.
SR9243
SR9243 is a potent and selective LXR inverse agonist. SR9243 kills cancer cells by inhibiting lipid production and the Warburg effect. Synonyms: SR9243; SR-9243; SR 9243. Grades: 98%. CAS No. 1613028-81-1. Molecular formula: C31H32BrNO4S2. Mole weight: 626.62.
SR9243
SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613028-81-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16972.
SR95531 (Gabazine, GABAA Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531)
A selective, competitive antagonist of GABAA receptor (IC50 = 440nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100uM). Also shown to block glycine receptors, but with low affinity (Kb = 190uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 104104-50-9. Pack Sizes: 10mg. US Biological Life Sciences.
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SR 95531 hydrobromide
SR 95531 hydrobromide is a competitive GABAA receptor antagonist. SR 95531 differs from bicuculline that it selectively antagonizes GABA-induced Cl- currents but exhibits little action on pentobarbitone-induced currents. SR 95531 also acts as a low affinity glycine receptor antagonist. Uses: Gaba antagonists. Synonyms: SR 95531 hydrobromide; SR95531 hydrobromide; SR-95531 hydrobromide; 4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid hydrobromide; 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide; Gabazine hydrobromide. Grades: ≥98% by HPLC. CAS No. 104104-50-9. Molecular formula: C15H17N3O3.HBr. Mole weight: 368.23.
SR 95531 hydrobromide
SR 95531 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 104104-50-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Src I1. Group: Biochemicals. Grades: Purified. CAS No. 179248-59-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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Src I1
Src I1 is a dual site inhibitor that competes at both the ATP and peptide binding sites of Src tyrosine kinase (IC50 = 44 and 88 nM for Src and Lck, respectively). Src I1 was reported to inhibit VEGFR2 and c-fms at higher concentrations (IC50 = 0.32 and 30 μM, respectively). Synonyms: Src I1; Src I-1; SrcI1. 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine; Src Kinase Inhibitor I; Src Inhibitor 1; Src Inhibitor-1. Grades: ≥99% by HPLC. CAS No. 179248-59-0. Molecular formula: C22H19N3O3. Mole weight: 373.4.
Src Inhibitor 1
Src Inhibitor 1 is a potent, ATP-competitive and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Src Kinase Inhibitor 1; Src-l1. CAS No. 179248-59-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101053.
The Src Inhibitor PP1, also referenced under CAS 172889-26-8, controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
Src Kinase Inhibitor I - CAS 179248-59-0
The Src Kinase Inhibitor I, also referenced under CAS 179248-59-0, controls the biological activity of Src Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
Src Kinase Inhibitor II - CAS 459848-35-2
The Src Kinase Inhibitor II, also referenced under CAS 459848-35-2, controls the biological activity of Src Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
SRF-DE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ChromoionophoreXIII,Semiphthorhodafluordecylester,DZ-49,7-[2-(Decyloxycarbonyl)-phenyl]-10-diethylamino-3-hydroxy-benzo[c]xanthyliumperchlorate. Product Category: Other Fluorophores. Appearance: Deep red powder. CAS No. 135656-96-1. Molecular formula: C38H44NO4·ClO4. Mole weight: 678.2. Purity: 95%+. IUPACName: [7-(2-decoxycarbonylphenyl)-3-hydroxybenzo[c]xanthen-10-ylidene]-diethylazanium;perchlorate. Canonical SMILES: CCCCCCCCCCOC(=O)C1=CC=CC=C1C2=C3C=CC(=[N+](CC)CC)C=C3OC4=C2C=CC5=C4C=CC(=C5)O.[O-]Cl(=O)(=O)=O. Product ID: ACM135656961-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: Sridevi.
SRI-011381
SRI-011381 is an activator of TGF-β signaling. Synonyms: N'-Cyclohexyl-N-(Phenylmethyl)-N-(4-Piperidinylmethyl)-Urea; SRI011381; SCHEMBL16099597; BCP30372; EX-A3008. Grades: 98%. CAS No. 1629138-41-5. Molecular formula: C20H31N3O. Mole weight: 329.5.
SRI-011381
SRI-011381 is an orally active TGF-? signaling agonist, exhibits neuroprotective effects[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1629138-41-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100347.
SRI-011381 hydrochloride
SRI-011381 hydrochloride is an orally active TGF-? signaling agonist, exhibits neuroprotective effects[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070014-88-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100347A.
SRI-37330 is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 can be used for type 2 diabetes research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2322245-42-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142114.
SRI-37330 free base
SRI-37330 is a novel inhibitor of TXNIP expression, decreasing glucagon secretion and action and blocking hepatic glucose output, reversing obesity- and STZ-induced diabetes and hepatic steatosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SRI-37330 free base; SRI37330 free base, SRI 37330 free base. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2322245-42-9. Molecular formula: C16H19F3N4O2S. Mole weight: 388.41. Purity: >98%. IUPACName: N-((1-(6-(trifluoromethyl)quinazolin-4-yl)piperidin-3-yl)methyl)methanesulfonamide. Canonical SMILES: CS(=O)(NCC1CN(C2=C3C=C(C(F)(F)F)C=CC3=NC=N2)CCC1)=O. Product ID: ACM2322245429. Alfa Chemistry ISO 9001:2015 Certified.