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| Product | Description | |
|---|---|---|
| SR-01000946410 | SR-01000946410 is a structural analog of PGE2 and a selective agonist for the EP2 receptor subtype. It binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor. It does not bind appreciably to any of the other murine EP receptors. BIt has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Synonyms: 15-deoxy-16S-hydroxy-17-cyclobutyl PGE1 methyl ester; TR 4979. Grades: ≥98%. CAS No. 69685-22-9. Molecular formula: C24H40O5. Mole weight: 408.6. |  |
| SR0987 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| SR 0987 | SR 0987 is a T cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay) that induces IL-17 expression and decreases PD-1 expression in T cells in vitro. Synonyms: SR-0987; SR0987; SR 0987; 2-Chloro-N-[4-[2, 2, 2-trifluoro-1-hydroxy-1- (trifluoromethyl) ethyl]phenyl]benzamide. Grades: ≥98% by HPLC. CAS No. 303126-97-8. Molecular formula: C16H10ClF6NO2. Mole weight: 397.7. | |
| SR1001 | Retinoic-acid-receptor-related orphan receptors (ROR) α and γ play a key role in the development of T-helper cells that produce interleukin-17 (TH17 cells), a subset of CD4+ T-cells that contribute to the inflammatory process and have been implicated in the pathology of autoimmune diseases. SR 1001 is a synthetic ligand specific for RORα and RORγ (Kis = 172 and 111 nM, respectively) that functions as an inverse agonist at these receptors. SR 1001 has been shown to suppress IL-17 promoter driven transcriptional activity by inhibiting the interaction of co-activators such as TRAP220 nuclear receptor box 2 peptide (IC50 = 117 nM) and SRC2 with RORα and RORγ as well as by increasing the recruitment of corepressors such as NCoR. At 5 μM, SR 1001 inhibits TH17 cell differentiation and IL-17A secretion in cultured splenocytes and human PBMCs. A 25 mg/kg dose of SR 1001 twice/day delays the onset and the severity of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. Synonyms: SR 1001; SR-1001. Grades: >98%. CAS No. 1335106-03-0. Molecular formula: C15H13F6N3O4S2. Mole weight: 477.4. | |
| SR1001 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SR1001 | SR1001 is a selective ROR α and ROR γt inverse agonist with K i s 172 and 111 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1335106-03-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13421. |  |
| SR 10067 | SR 10067 is a selective and cell-permeable Rev-Erbα/β agonist (IC50 = 160 and 170 nM for Rev-Erbβ and Rev-Erbα, respectively). SR 10067 has no significant activity against a wide range of nuclear receptors, other receptors, ion channels and transporters at 20 μM. SR 10067 has effects of increasing wakefulness, reducing REM and slow wave sleep in vivo. Synonyms: SR 10067; SR-10067; SR-10067; [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone. Grades: ≥98% by HPLC. CAS No. 1380548-02-6. Molecular formula: C31H31NO3. Mole weight: 465.58. | |
| SR1078 | SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays. Synonyms: SR 1078; SR-1078. Grades: >98%. CAS No. 1246525-60-9. Molecular formula: C17H10F9NO2. Mole weight: 431.25. | |
| SR 11023 | SR 11023 is an orally active antagonist of PPAR γ, with the IC 50 value of 109 nM that plays an important role in diabetic research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1820602-13-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160162. | |
| SR11237 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SR 11237 | SR 11237. Group: Biochemicals. Grades: Purified. CAS No. 146670-40-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| SR 11237 | SR 11237 is a pan retinoid X receptor (RXR) agonist with no RAR activity. Synonyms: SR12813; SR 12813; SR-12813. 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoic acid. Grades: ≥98% by HPLC. CAS No. 146670-40-8. Molecular formula: C24H28O4. Mole weight: 380.48. | |
| SR 11237 | SR 11237 is a pan retinoid X receptor (RXR) agonist. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SR 11237; SR11237; SR-11237; BMS 649; BMS-649; BMS649; BMS 188649; BMS-188649; BMS188649. Product Category: Agonists. Appearance: Solid powder. CAS No. 146670-40-8. Molecular formula: C24H28O4. Mole weight: 380.48. Purity: >98%. IUPACName: 4-(2-(5,6,7,8-Tetrahydro-5,5,8,8,-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl)benzoic acid. Canonical SMILES: O=C(O)C1=CC=C(C2(C3=CC=C4C(C)(C)CCC(C)(C)C4=C3)OCCO2)C=C1. Product ID: ACM146670408-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| SR 11302 | SR 11302. CAS No: 160162-42-5 |  Sarchem Laboratories New Jersey NJ |
| SR 11302 | SR 11302. Group: Biochemicals. Grades: Purified. CAS No. 160162-42-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SR 11302 | SR 11302 is an inhibitor of activator protein-1 (AP-1), which is a transcription factor activity that displays antitumor effects in vivo. SR 11302 does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα). Synonyms: SR 11302; SR11302; SR-11302; (E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; (2E,4E,6Z,8E)-3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid. Grades: ≥98% by HPLC. CAS No. 160162-42-5. Molecular formula: C26H32O2. Mole weight: 376.54. | |
| SR121566A | SR121566A, a non-peptide Glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist, has been shown to block platelet aggregation induced by a wide variety of agonists including HIT serum/heparin, reduced in a dose-dependent manner the HIT serum/heparin-induced, platelet mediated expression and release of the above mentioned proteins. Synonyms: 3-[[1-(carboxymethyl)piperidin-4-yl]-[4-(4-methanehydrazonoylphenyl)-1,3-thiazol-2-yl]amino]propanoic acid; CTK0H1193; 1-Piperidineaceticacid, 4-[[4-[4-(aminoiminomethyl)phenyl]-2-thiazolyl](2-carboxyethyl)amino]-. CAS No. 180144-61-0. Molecular formula: C20H25N5O4S. Mole weight: 431.51. | |
| SR12813 | SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase , with an IC 50 value of 0.85 μM [1] [2]. SR12813 is also an efficient agonist of human pregnane X receptor ( hPXR ). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR) [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW 485801. CAS No. 126411-39-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-100793. | |
| SR 12813 | SR 12813 is a pregnane X receptor (PXR) agonist (EC50 = 200 and 700 nM for human and rabbit PXR, respectively) that activates the farnesoid X receptor (FXR) at μM concentrations. SR 12813 exhibits hypocholesterolaemic activity via enhancing the degradation of HMG-CoA reductase. Synonyms: SR 12813; SR12813; SR-12813; [[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonic acid tetraethyl ester; 4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol. Grades: ≥99% by HPLC. CAS No. 126411-39-0. Molecular formula: C24H42O7P2. Mole weight: 504.53. | |
| SR 12813 | SR 12813. Group: Biochemicals. Grades: Purified. CAS No. 126411-39-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR13668 | SR13668 is an Akt inhibitor, is also an orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities. Akt inhibitor SR13668 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation, and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Synonyms: SR 13668; SR-13668; 2,10-dicarbethoxy-6-methoxy-5,7-dihydro-indolo[2,3-b]carbazole. CAS No. 637774-61-9. Molecular formula: C25H22N2O5. Mole weight: 430.46. | |
| SR 13800 | SR 13800 is a potent MCT1 inhibitor (IC50 = 0.5 nM). SR 13800 was shown to inhibit proliferation of Raji lymphoma cells in vitro and suppress lactate uptake in breast cancer cells in vitro. Synonyms: SR13800; SR-13800; SR 13800; 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one; 5-(3-hydroxypropylsulfanyl)-3-methyl-1-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)pyrrolo[3,4-d]pyridazin-4-one. Grades: ≥98% by HPLC. CAS No. 227321-12-2. Molecular formula: C25H29N3O2S. Mole weight: 435.58. | |
| SR 140333 | SR 140333. Group: Biochemicals. Grades: Purified. CAS No. 153050-21-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 140333 | SR 140333 is a potent NK1 receptor antagonist (Ki = 0.74 nM. IC50 = 1.6 nM). SR 140333 inhibits substance P-invoked calcium mobilization and outward current (IC50 = 1.3 nM), and suppresses NK1-mediated nitric oxide-dependent vasodilation in vivo. Synonyms: SR 140333; SR 140,333; SR 140333A; 1-[2-[(3S)-3-(3,4-Dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride. Grades: ≥97% by HPLC. CAS No. 153050-21-6. Molecular formula: C37H45Cl3N2O2. Mole weight: 656.12. | |
| SR 141716A | SR 141716A. Group: Biochemicals. Grades: Purified. CAS No. 158681-13-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 142948 | SR 142948. Group: Biochemicals. Grades: Purified. CAS No. 184162-64-9. Pack Sizes: 1mg, 10mg. US Biological Life Sciences. | Worldwide |
| SR 142948 | SR 142948 is an orally active and selective non-peptide neurotensin receptor ( NT ) antagonist with IC 50 s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. SR 142948 antagonizes NT-induced inositol monophosphate formation in HT-29 cells with an IC50 of 3.9 nM. SR 142948 blocks hypothermia, analgesia and steering behavior induced by NT in vivo. SR 142948 shows blood-brain permeability and can be used in study of psychiatric disorders [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 184162-64-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107664. | |
| SR142948A | SR142948A is an antagonist of non-peptide neurotensin (NT) receptor with a high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). SR142948A has the effect of inhibiting bile acid secretion and some stimulant drugs. Uses: An antagonist of non-peptide neurotensin (nt) receptor with an effect of bile acid secretion inhibition. Synonyms: SR 142948; SR 142948A; CHEMBL2431105; CHEMBL 2431105; CHEMBL-2431105; AC1NSKNX. Grades: ≥98 %. CAS No. 184162-64-9. Molecular formula: C39H51N5O6. Mole weight: 685.86. | |
| SR 142948A | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SR 142948A | SR 142948A is a non-peptide neuropeptide neuropeptin ( NT ) receptor antagonist. SR 142948A is able to bind to neuropeptin receptors, especially with high affinity for NT1 and NT2 receptors. SR 142948A is mainly used to study the role of neuropeptide in the neurotransmitter system, especially the dopamine system [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 184162-21-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-124767. | |
| SR 144528 | SR 144528. Group: Biochemicals. Alternative Names: (1S-endo)-5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-(1, 3, 3-trimethylbicyclo[2. 2. 1]hept-2-yl)-1H-Pyrazole-3-carboxamide. Grades: Highly Purified. CAS No. 192703-06-3. Pack Sizes: 5mg. Molecular Formula: C29H34ClN3O, Molecular Weight: 476.05. US Biological Life Sciences. | Worldwide |
| SR 144528 | SR 144528 is a cannabinoid (CB) receptor 2 inverse agonist with selectivity for CB2 over CB1 receptors. It antagonizes the inhibitory effects of the cannabinoid receptor agonist CP 55,940 on forskolin-stimulated adenylyl cyclase activity in cell lines permanently expressing the h CB2 receptor. It selectively blocks the mitogen-activated protein kinase activity induced by CP 55,940 in cell lines expressing h CB2. Synonyms: SR144528; SR-144528; 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethyl-2-bicyclo[2.2.1]heptanyl]pyrazole-3-carboxamide. Grades: ≥98%. CAS No. 192703-06-3. Molecular formula: C29H34ClN3O. Mole weight: 476.1. | |
| SR15006 | SR15006 is a inhibitor of Krüppel-like factor 5 (KLF5). SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo. SR18662 significantly reduces growth and proliferation of colorectal cancer cells as compared with treatment with vehicle control, SR18662 showed improved efficacy in reducing the viability of multiple colorectal cancer cell lines. SR18662 treatment also reduces the expression of cyclins and components of the MAPK and WNT signaling pathways. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SR15006; SR-15006; SR 15006. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2505001-54-5. Molecular formula: C16H20ClN3O4S. Mole weight: 385.86. Purity: >98%. IUPACName: (E)-3-(3-chlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide. Canonical SMILES: O=C(NCC(N1CCN(S(=O)(C)=O)CC1)=O)/C=C/C2=CC=CC(Cl)=C2. Product ID: ACM2505001545. Alfa Chemistry ISO 9001:2015 Certified. | |
| SR1555 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SR 1555 hydrochloride | SR 1555 is an inverse agonist of RORγ with IC50 value of 1 μM. It inhibits endogenous IL-17A gene expression in mouse splenocytes and suppresses differentiation of TH17 cells when cultured under TH17 polarizing conditions. It is effective against various autoimmune diseases. Synonyms: 1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethanone monohydrochloride. Grades: ≥98%. CAS No. 1386439-51-5. Molecular formula: C22H22F6N2O2·HCl. Mole weight: 496.88. | |
| SR 16584 | SR 16584 is a selective α3β4 nAChR antagonist (IC50 = 10.2 μM) with selectivity for α3β4 over α4β2 and α7 subtypes (Ki = 0.508, >100 and >100 μM, respectively). Synonyms: 1,3-Dihydro-1-(3-exo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indol-2-one. Grades: ≥98% by HPLC. CAS No. 1150153-86-8. Molecular formula: C17H22N2O. Mole weight: 270.37. | |
| SR 16584 | SR 16584. Group: Biochemicals. Alternative Names: 1,3-Dihydro-1-[(3-exo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indol-2-one. Grades: Highly Purified. CAS No. 1150153-86-8. Pack Sizes: 10mg. Molecular Formula: C17H22N2O, Molecular Weight: 270.37. US Biological Life Sciences. | Worldwide |
| SR 1664 | SR 1664 is a PPARγ (peroxisome proliferator-activated receptor γ ) inhibitor. SR 1664 can block PPARγ by cyclin-dependent kinase 5 with an IC50 value of 80 nM and it does not exhibit agonist activity at the PPARγ receptor. Recent research shows that SR 1664 has anti-diabetic effects in obese mice. Uses: Antidiabetic activity. Synonyms: SR1664; SR-1664; SR 1664. (S)-4'-((2,3-dimethyl-5-((1-(4-nitrophenyl)ethyl)carbamoyl)-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid. Grades: 98%. CAS No. 1338259-05-4. Molecular formula: C33H29N3O5. Mole weight: 547.61. | |
| SR 1664 | SR 1664. Group: Biochemicals. Grades: Purified. CAS No. 1338259-05-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 16832 | SR 16832 is a dual site covalent PPARγ inhibitor that acts at orthosteric and allosteric sites [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2088135-12-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112247. | |
| SR 16832 | SR 16832 is a dual-site covalent antagonist of PPARγ, acting at orthosteric and allosteric sites in the ligand binding domain. It inhibits MRL20-induced allosteric activation of PPARγ in a reporter assay using HEK293T cells when used at a concentration of 5 μM. Synonyms: 2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide. Grades: ≥98%. CAS No. 2088135-12-8. Molecular formula: C17H12ClN3O4. Mole weight: 357.75. | |
| SR17018 | SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC 50 of 97 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2134602-45-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111454. | |
| SR 17018 | SR 17018 is an orally bioavailable and brain-penetrant agonist of μ-opioid receptors (MOR). Synonyms: 5,6-Dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one. Grades: ≥98%. CAS No. 2134602-45-0. Molecular formula: C19H18Cl3N3O. Mole weight: 410.72. | |
| SR 18292 | SR 18292 is an inhibitor of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). It reduces blood glucose, potently increases hepatic insulin sensitivity, and improves glucose homeostasis in dietary and genetic mouse models of type 2 diabetes. Synonyms: 1-[Tert-butyl-[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)propan-2-ol. Grades: ≥95%. CAS No. 2095432-55-4. Molecular formula: C23H30N2O2. Mole weight: 366.5. | |
| SR1848 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SR18662 | SR18662 is an optimized anticancel agent based on ML264. SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo. SR18662 showed improved efficacy in reducing the viability of multiple colorectal cancer cell lines. Flow cytometry analysis following SR18662 treatment showed an increase in cells captured in either S or G2-M phases of the cell cycle and a significant increase in the number of apoptotic cells, the latter a unique property compared with ML264 or SR15006. SR18662 treatment also reduces the expression of cyclins and components of the MAPK and WNT signaling pathways. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SR18662; SR-18662; SR 18662. Product Category: Others. Appearance: Solid powder. CAS No. 2505001-62-5. Molecular formula: C16H19Cl2N3O4S. Mole weight: 420.31. Purity: >98%. IUPACName: (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide. Canonical SMILES: O=C(NCC(N1CCN(S(=O)(C)=O)CC1)=O)/C=C/C2=CC=C(Cl)C(Cl)=C2. Product ID: ACM2505001625. Alfa Chemistry ISO 9001:2015 Certified. | |
| SR 1903 | SR 1903 is an inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and an agonist of liver X receptor (LXR). It also binds to PPARγ without activity. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity. Synonyms: 1-[2'-Methyl-4'-[[4-(4-pyridylmethyl)-1-piperazinyl]methyl]-4-biphenylyl]-1-(trifluoromethyl)-2,2,2-trifluoroethanol. Grades: ≥98%. CAS No. 1414248-06-8. Molecular formula: C27H27F6N3O. Mole weight: 523.51. | |
| SR 202 | SR 202 is a selective PPARγ antagonist used as an antidiabetic and antiobesity agent. SR 202 inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo, improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo. Synonyms: Mifobate; SR 202; SR-202; SR202; (4-Chlorophenyl) (dimethoxyphosphinyl)methyl phosphoric acid dimethyl ester; Mifobate; Clenicor. Grades: ≥99% by HPLC. CAS No. 76541-72-5. Molecular formula: C11H17ClO7P2. Mole weight: 358.65. | |
| SR 202 | SR 202. Group: Biochemicals. Grades: Purified. CAS No. 76541-72-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR-202 | ?98% (HPLC), crystalline. Group: Fluorescence/luminescence spectroscopy. | |
| SR2211 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SR 2211 | SR 2211 is a selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). SR 2211 exhibits weak activity at liver X receptor α (LXRα) and has no effect on transcriptional activity of farnesoid X receptors (FXR) or transcriptional activity of ROR&alpha. Synonyms: SR-2211; SR2211;SR 2211; 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol; 1,1,1,3,3,3-hexafluoro-2-[3-fluoro-4-[4-[[4-(pyridin-4-ylmethyl)piperazin-1-yl]methyl]phenyl]phenyl]propan-2-ol. Grades: ≥98% by HPLC. CAS No. 1359164-11-6. Molecular formula: C26H24F7N3O. Mole weight: 527.48. | |
| SR2595 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SR 2595 | SR 2595 is an inverse agonist of PPARγ (IC50 = 30 nM) that represses both transactivation in a promoter:reporter assay and expression of the adipogenic marker fatty acid-binding protein 4 in differentiating murine preadipocytes. Synonyms: 2-[4-[[5-[[(1S)-1-(4-Tert-butylphenyl)ethyl]carbamoyl]-2,3-dimethylindol-1-yl]methyl]phenyl]benzoic acid. Grades: ≥98%. CAS No. 1415252-61-7. Molecular formula: C37H38N2O3. Mole weight: 558.7. | |
| SR 2640 hydrochloride | SR 2640 hydrochloride is a potent and selective competitive leukotriene D4 and E4 receptor antagonist. SR 2640 has been shown to inhibit LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). It also inhibits LTD4-attenuation of human PMN chemotaxis. Synonyms: SR 2640 hydrochloride; SR2640 hydrochloride; SR-2640 hydrochloride; 2-[[3- (2-Quinolinylmethoxy) phenyl]amino]benzoic acid hydrochloride. Grades: ≥99% by HPLC. CAS No. 146662-42-2. Molecular formula: C23H18N2O3.HCl. Mole weight: 406.87. | |
| SR 2640 Hydrochloride | Potent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4- attenuation of human PMN chemotaxis. Group: Biochemicals. Alternative Names: 2-[[3- (2-Quinolinylmethoxy) phenyl]amino]benzoic acid hydrochloride. Grades: Highly Purified. CAS No. 146662-42-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 27417 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SR 27897 | SR 27897 is a potent and non-peptide CCK1 receptor antagonist displaying > 33-fold selectivity over CCK2 receptors (EC50 = 6 and 200 nM, respectively). It was shown to increase plasma leptin levels and promote food intake in rats in vivo. SR 27897 is used for the treatment of pancreatic cancer. Uses: The treatment of pancreatic cancer. Synonyms: SR-27897; SR27897; SR 27897; 2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid; Lintitript. Grades: ≥99% by HPLC. CAS No. 136381-85-6. Molecular formula: C20H14ClN3O3S. Mole weight: 411.86. | |
| SR 27897 | SR 27897. Group: Biochemicals. Grades: Purified. CAS No. 136381-85-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR-3029 | SR-3029, a small molecule inhibitor that targets specificly CK1δ/CK1ε, was effective at reducing the growth of breast cancer in multiple mouse models without any signs of major toxicity. IC50=97 nM. Synonyms: N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-morpholin-4-ylpurin-6-amine;SR-3029; SR 3029; SR3029;SCHEMBL15243359; SCHEMBL17132207; CS-5672; CS 5672; CS5672; HY-100011; 1454585-06-8. CAS No. 1454585-06-8. Molecular formula: C23H19F3N8O. Mole weight: 480.45. | |
| SR-3029 | SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with potent antiproliferative properties SR-3029 shoed IC50:= 97 nM in MTT assays against the human A375 melanoma cell line and have physical, in vitro and in vivo PK properties suitable for use in proof of principle animal xenograft studies against human cancer cell lines. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SR-3029; SR 3029; SR3029. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1454585-06-8. Molecular formula: C23H19F3N8O. Mole weight: 480.46. Purity: >98%. IUPACName: (6,7-Difluoro-1H-benzoimidazol-2-ylmethyl)-[9-(3-fluoro-phenyl)-2-morpholin-4-yl-9H-purin-6-yl]-amine. Canonical SMILES: FC1=CC(N2C=NC3=C(NCC4=NC5=CC=C(F)C(F)=C5N4)N=C(N6CCOCC6)N=C23)=CC=C1. Product ID: ACM1454585068. Alfa Chemistry ISO 9001:2015 Certified. Categories: SR 302 (VA). | |
| SR-31747 | SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 132173-07-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13751. | |
| SR-31747 | SR-31747 is a new sigma ligand, which elicited a suppressive effect on immune responses through the sigma receptor expressed on lymphocytes. Synonyms: N-Cyclohexyl-N-ethyl-3-(3-chloro-4-cyclohexylphenyl)propen-2-ylamine hydrochloride; SR 31747 HCl. Grades: 98%. CAS No. 132173-07-0. Molecular formula: C23H35Cl2N. Mole weight: 396.44. | |
| SR-3306 | SR-3306, an aminopyrimidine derivative, is a JNK Inhibitor and could be mainly active in Phosphorylation & Dephosphorylation actions. Uses: Sr-3306 is a jnk inhibitor and could be mainly active in phosphorylation & dephosphorylation actions. Synonyms: SR-3306; SR-3306; SR-3306. Grades: 98%. CAS No. 1128096-91-2. Molecular formula: C28H26N8O. Mole weight: 490.56. | |
| SR3335 | The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles. SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM). It has no effect on RORβ, RORγ, farnesoid X receptor, or liver X receptor &alpha. SR 3335 evokes RORα-dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis. Synonyms: ML-176; SR 3335; SR-3335; ML176; ML 176. Grades: >98%. CAS No. 293753-05-6. Molecular formula: C13H9F6NO3S2. Mole weight: 405.34. | |
| SR33805 | SR33805 is a potent Ca 2+ channel antagonist, with EC 50 s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca 2+ channels. SR33805 can be used for the research of acute or chronic failing hearts [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 121345-64-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-136909. | |
| SR 33805 oxalate | SR 33805 oxalate. Group: Biochemicals. Grades: Purified. CAS No. 121346-33-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SR 33805 oxalate | SR 33805 oxalate is a potent Ca2+ channel antagonist that binds allosterically to the a1-subunit of L-type Ca2+ channels (Kd = 20 pM). SR 33805 displays selectivity for vascular smooth muscle, inducing vasorelaxation with no inotropic or chronotropic effects. It exhibits an inhibitory effect on PDGF-stimulated smooth muscle cell proliferation. Synonyms: SR 33805 oxalate; SR33805 oxalate; SR-33805 oxalate; 3, 4-Dimethoxy-N-methyl-N- [3- [4- [ [1-methyl-3- (1-methylethyl) -1H-indol-2-yl] sulfonyl] phenoxy] propyl] benzeneethanamine. Grades: ≥99% by HPLC. CAS No. 121346-33-6. Molecular formula: C32H40N2O5S.C2H2O4. Mole weight: 654.77. | |
| SR 3576 | SR 3576 is a potent and selective JNK3 inhibitor (IC50 = 7 nM) with > 2800-fold selectivity over p38. Synonyms: SR-3576; SR 3576; SR3576; 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide; JNK3 Inhibitor XII; SR-3576; Aminopyrazole inhibitor, 3576. Grades: ≥97% by HPLC. CAS No. 1164153-22-3. Molecular formula: C27H27N5O5. Mole weight: 501.53. | |
| SR 3576 | SR 3576. Group: Biochemicals. Grades: Purified. CAS No. 1164153-22-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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