A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
SPR719 (VXc-486) is an orally active gyrase B inhibitor, with bactericidal activity. SPR719 potently inhibits multiple agent-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis , with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively. SPR719 is promising for research of lung disease caused by non-tuberculous mycobacteria (NTM) [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VXc-486. CAS No. 1384984-18-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12930.
SPR741
SPR741 is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 TFA. Synonyms: NAB741. Grades: >98%. CAS No. 1179330-52-9. Molecular formula: C44H73N13O13. Mole weight: 992.13.
S-Pralatrexate
The S isometric form of Pralatrexate which is a 10-deazaaminopterin analog of methotrexate, and is an inhibitor of DHFR. Synonyms: Pralatrexate, (S)-; 1320211-69-5; UNII-0892G4T376; 0892G4T376; L-Glutamic acid, N-(4-((1S)-1-((2,4-diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-; (4-((S)-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamic acid; (S)-pralatrexate; SCHEMBL1890561; DTXSID601031325; AKOS040747300; Q27236394; (2S)-2-[[4-[(2S)-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioic acid. Grades: > 95%. CAS No. 1320211-69-5. Molecular formula: C23H23N7O5. Mole weight: 477.48.
Spray Nozzles
Spray Nozzles. Group: Polymers.
SPRi 3
SPRi 3 is a potent inhibitor of sepiapterin reductase (SPR) with IC50 value of 53-74 nM for human SPR. It inhibits BH4 synthesis pathway and attenuates proliferation in naive CD4+ T cells. Synonyms: N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide. Grades: ≥98% by HPLC. CAS No. 1292285-54-1. Molecular formula: C14H18N2O3. Mole weight: 262.3.
S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H 2 S-releasing compound. S-Propargylcysteine reduces Ca 2+ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SPRC. CAS No. 3262-64-4. Pack Sizes: 100 mg; 250 mg. Product ID: HY-W001538.
S-Propargyl-Cysteine
S-Propargyl-cysteine (SPRC) is a modulator of endogenous hydrogen disulfide (H2S) with antioxidant activity. SPRC is potentially used for the treatment of Alzheimer's disease (TNF signaling, the NF-κB pathway and the ERK1/2 pathway), anemia of inflammation (IL-6/JAK2/STAT3 pathway), ischemic heart disease (H2S/VEGFR2/STAT3 pathway) and myocardial infarction. Synonyms: (2R)-2-amino-3-prop-2-ynylsulfanylpropanoic acid; SPRC. Grades: 98%. CAS No. 3262-64-4. Molecular formula: C6H9NO2S. Mole weight: 159.21.
S-Propyl-2-thiobarbituric Acid
S-Propyl-2-thiobarbituric Acid. Group: Biochemicals. Alternative Names: 6-Hydroxy-2-(propylthio)-4(1H)-pyrimidinone; 2-(Propylthio)pyrimidine-4,6-diol. Grades: Highly Purified. CAS No. 145783-12-6. Pack Sizes: 250mg. Molecular Formula: C7H10N2O2S, Molecular Weight: 186.23. US Biological Life Sciences.
Worldwide
S-Propyl-5-nitro-2-thiobarbituric Acid
S-Propyl-5-nitro-2-thiobarbituric Acid. Group: Biochemicals. Alternative Names: 6-Hydroxy-5-nitro-2-(propylthio)-4(1H)-pyrimidinone; 5-Nitro-2-(propylthio)pyrimidine-4,6-diol. Grades: Highly Purified. CAS No. 145783-13-7. Pack Sizes: 100mg. Molecular Formula: C7H9N3O4S, Molecular Weight: 231.23. US Biological Life Sciences.
Worldwide
S-Propyl-5-nitro-2-thiobarbituric-d7 Acid
S-Propyl-5-nitro-2-thiobarbituric-d7 Acid. Group: Biochemicals. Alternative Names: 6-Hydroxy-5-nitro-2-(propylthio)-4(1H)-pyrimidinone-d7; 5-Nitro-2-(propylthio)pyrimidine-4,6-diol-d7. Grades: Highly Purified. CAS No. 1265919-34-3. Pack Sizes: 10mg. Molecular Formula: C7H2D7N3O4S, Molecular Weight: 238.27. US Biological Life Sciences.
Worldwide
S(+)-Propylene glycol
1g Pack Size. Group: Building Blocks, Organics, Solvents. Formula: C3H8O2. CAS No. 4254-15-3. Prepack ID 43121408-1g. Molecular Weight 76.09. See USA prepack pricing.
S-Propylglutathione
Cas No. 24425-53-4. Mole weight: 349.40.
S-Propyl N,N-Diethyldithiocarbamate
S-Propyl N, N-Diethyl dithiocarbamate. Group: Biochemicals. Alternative Names: N,N-Diethyl S-propyl Dithiocarbamate. Grades: Highly Purified. CAS No. 19047-77-9. Pack Sizes: 250mg. Molecular Formula: C8H17NS2, Molecular Weight: 191.36. US Biological Life Sciences.
Worldwide
S-Propyl N,N-Diethyldithiocarbamate-d7
S-Propyl N,N-Diethyldithiocarbamate-d7. Group: Biochemicals. Alternative Names: N,N-Diethyl S-propyl Dithiocarbamate-d7. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C8H10D7NS2, Molecular Weight: 198.4. US Biological Life Sciences.
Spruce Oil Type. CAS No. MIXTURE. Kosher: Y. VIGON Item # 504148. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers.
America & Internationally
SpStrongylocin 1
SpStrongylocin 1 is an antimicrobial peptide isolated from Strongylocentrotus purpuratus. It has activity against gram-positive bacteria and gram-negative bacteria. Synonyms: Ile-Phe-Asn-Ser-Ile-Tyr-His-Arg-Lys-Cys-Val-Val-Lys-Asn-Arg-Cys-Glu-Thr-Val-Ser-Gly-His-Lys-Thr-Cys-Lys-Asp-Leu-Thr-Cys-Cys-Arg-Ala-Val-Ile-Phe-Arg-His-Glu-Arg-Pro-Glu-Val-Cys-Arg-Pro-Ser-Thr.
SpStrongylocin 2
SpStrongylocin 2 is an antimicrobial peptide isolated from Strongylocentrotus purpuratus. It has activity against gram-positive bacteria and gram-negative bacteria. Synonyms: Trp-Asn-Pro-Phe-Arg-Lys-Leu-Tyr-Arg-Lys-Glu-Cys-Asn-Asp-Val-Thr-Ser-Cys-Asp-Thr-Val-Ser-Gly-Val-Lys-Thr-Cys-Thr-Lys-Lys-Asn-Cys-Cys-His-Arg-Lys-Phe-Phe-Gly-Lys-Thr-Ile-Leu-Lys-Ala-Pro-Glu-Cys-Thr-Val-Ile-Ser.
SPT Imidazopyridine 1
SPT Imidazopyridine 1 is a potent serine palmitoyl transferase (SPT) inhibitor (IC50 = 5 nM) used for the treatment of type 2 diabetes and dyslipidemia. SPT Imidazopyridine 1 inhibits incorporation of 14C-serine into ceramide in dose manner, and lowers plasma ceramide levels in vivo. It also has the effect of increasing plasma HDL and reducing VLDL cholesterol levels in rats. Synonyms: SPT-IN-1; SPT IN 1; SPT Inhibitor 1; Imidazopyridine 1; 4-[6-(1-Oxoheptyl)imidazo[1,2-a]pyridin-8-yl]benzeneacetic acid; 2-[4-(6-heptanoylimidazo[1,2-a]pyridin-8-yl)phenyl]acetic acid; SPT-IN-1. Grades: ≥98%. CAS No. 1933533-18-6. Molecular formula: C22H24N2O3. Mole weight: 364.44.
Sp-TTP-α-S
Sp-TTP-α-S is used for regulation of TTP-responsive receptors and determination of their stereospecificity. Compared to TTP, it is much more stable. Uses: Antiviral agents. Synonyms: Thymidine- 5'- O- (1-thiotriphosphate), Sp-isomer. Grades: ≥ 95% by HPLC. CAS No. 83199-32-0. Molecular formula: C10H17N2O13P3S (free acid). Mole weight: 498.2 (free acid).
SPUTOLYSIN Reagent - CAS 578517
Intended for the isolation of epithelial cells, pathogenic or saprophytic bacteria, fungi, and yeasts from sputum. Group: Fluorescence/luminescence spectroscopy.
SQ01. Uses: Designed for use in research and industrial production. Product Category: Dye-Sensitized Solar Cell (DSSC). CAS No. 951248-19-4. Product ID: ACM951248194. Alfa Chemistry ISO 9001:2015 Certified. Categories: SQ109.
SQ02
SQ02. Uses: Designed for use in research and industrial production. Product Category: Dye-Sensitized Solar Cell (DSSC). CAS No. 1240041-84-2. Product ID: ACM1240041842. Alfa Chemistry ISO 9001:2015 Certified. Categories: SQL:2003.
SQ109
SQ109 is a novel antitubercular drug. It was screened out from a big chemical library designed around the active pharmacophore of ethambutol (EMB). SQ109 displayed potent activity against all the substrains of Mtb including XDR- and MDR-TB clinical strains. Synonyms: SQ109; SQ-109; SQ 109; NSC 722041; NSC-722041; NSC722041. Grades: >98%. CAS No. 502487-67-4. Molecular formula: C22H38N2. Mole weight: 330.55.
SQ109
SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC 50 for cell killing of 50±8 nM. SQ109, targets MmpL3 , is an antitubercular agent. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 722041. CAS No. 502487-67-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14989.
SQ-22536, also known as NSC 53339, is a cell-permeable adenylyl cyclase inhibitor (IC50 = 20 μM in detergent-dispersed rat brain preparation). SQ 22536 has demonstrated inhibition of the effect of glucagon on rat membrane cyclase activity and has reduced the effect of isoproterenol, epinephrine, norepinephrine, and phenylephrine. Synonyms: 9-(tetrahydro-2-furanyl)-9H-purin-6-amine; SQ-22536; SQ22536; SQ 22536; SQ-22,536; SQ22,536; SQ 22,536. NSC 53339. CAS No. 17318-31-9. Molecular formula: C9H11N5O. Mole weight: 205.22.
SQ28603 is a selective neutral endopeptidase (NEP 3.4.24.11) inhibitor. Synonyms: 3-[(2-benzyl-3-sulfanylpropanoyl)amino]propanoic acid; SQ 28,603; SQ 28603; SQ-28603. CAS No. 100845-83-8. Molecular formula: C13H17NO3S. Mole weight: 267.34.
SQ 29548
SQ 29548 is a potent and selective TP receptor antagonist. It inhibits the aggregation of washed human platelets induced by U-46619 with an IC50 of 0.06 μM. Synonyms: SQ-29548; SQ29548; (Z)-7-[(1S,2R,3R,4R)-3-[[2-(phenylcarbamoyl)hydrazinyl]methyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid. Grades: ≥98%. CAS No. 98672-91-4. Molecular formula: C21H29N3O4. Mole weight: 387.5.
SQDG
SQDG is a glycolipid that possesses sugar moieties in their head groups. SQDG is a membrane lipid that can be used to investigate the effects of structural lipid in LNP formulations [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 123036-44-2. Pack Sizes: 1 mg. Product ID: HY-143692.
Squalamine
Squalamine is an aminosterol compound with potent broad spectrum antiviral activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3beta-N-1-(N-[3-(4-Aminobutyl)]- 1,3-diaminopropane)-7alpha,24R-dihydroxy-5alpha-cholestane 24-sulfate. Product Category: Inhibitors. Appearance: Solid. CAS No. 148717-90-2. Molecular formula: C34H65N3O5S. Mole weight: 628. Purity: 95%+. IUPACName: [(3R,6R)-6-[(3S,5R,7R,8R,9S,10S,13R,14S,17R)-3-[3-(4-Aminobutylamino)propylamino]-7-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptan-3-yl] hydrogen sulfate. Canonical SMILES: C[C@@]12[C@](C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CC[C@H](C(C)C)OS(=O)(O)=O)C)([H])C[C@@H](NCCCNCCCCN)CC1. Density: 1.13±0.1 g/cm³. Product ID: ACM148717902. Alfa Chemistry ISO 9001:2015 Certified.
Squalamine
Squalamine is a naturally derived broad-spectrum antibiotic that is predominantly derived from the livers of dogfish and other shark species. Squalamine is undergoing trials for treatment of non-small cell lung cancer (stage I/IIA) as well as general phase I pharmacokinetic studies. In 2005, the Food and Drug Administration granted squalamine Fast Track status for approval for treatment of age-related macular degeneration. However, the Genaera Corporation, the company that has done the most work with squalamine, discontinued trials for its use in treating prostate cancer and wet age-related macular degeneration in 2007. The Squalamine project was acquired by Ohr Pharmaceutical from the now liquidated Genaera, with the prospect of continuing the development of this drug to treat wet age-related macular degeneration. Synonyms: MSI 1256; MSI-1256; MSI1256. Grades: ≥98% (HPLC). CAS No. 148717-90-2. Molecular formula: C34H65N3O5S. Mole weight: 627.96.
Squalamine
Squalamine (MSI-1256) is an aminosterol compound with broad-spectrum antiviral activity. Squalamine makes cells less conducive to certain viral replication by altering the electrostatic interactions in the inner membrane of host cells. Squalamine also has antibacterial and antitumor activities. Squalamine has broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, fungi and protozoa. Squalamine inhibits tumor-related angiogenesis and the growth of human breast cancer cells. Squalamine restores the function of enteric nervous system in Parkinson , s disease mouse models [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: MSI-1256. CAS No. 148717-90-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-16468.
Squalamine lactate
Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration. Uses: Scientific research. Group: Natural products. Alternative Names: MSI-1256F. CAS No. 320725-47-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-16467.
United States Pharmacopeia (USP) Reference Standard. Uses: For analytical and research use. Group: Pharmacopeia & metrological institutes standards; hydrocarbons & petrochemicals; european pharmacopoeia (ph. eur.); pharmacopoeial standards. Alternative Names: 2,6,10,15,19,23-Hexamethyltetracosane, perhydrosqualene,Squalane. CAS No. 111-01-3. Pack Sizes: 500MG. IUPAC Name: 2,6,10,15,19,23-hexamethyltetracosane. Molecular formula: C30H62. Mole weight: 422.81. Catalog: APS111013. SMILES: CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C. Format: Neat.
Squalane
Squalane. Group: Biochemicals. Alternative Names: 2,6,10,15,18,23-Hexamethyltetracosane. Grades: Highly Purified. CAS No. 111-01-3. Pack Sizes: 100g, 250g, 500g, 1kg, 2kg. Molecular Formula: C30H62. US Biological Life Sciences.
Worldwide
Squalane
100g Pack Size. Group: Building Blocks, Organics. Formula: [(CH3)2CH(CH2)3CH(CH3)(CH2)3CH(CH3)CH2CH2]2. CAS No. 111-01-3. Prepack ID 13053317-100g. Molecular Weight 422.81. See USA prepack pricing.
Squalane
Squalane is commonly used as an emollient and moisturizer. Synonyms: 2,6,10,15,19,23-hexamethyltetracosane. CAS No. 111-01-3. Molecular formula: C30H62. Mole weight: 422.81.
Squalane
Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities [1]. Uses: Scientific research. Group: Natural products. CAS No. 111-01-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-N7113.
Squalane
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standardshydrocarbons & petrochemicalseuropean pharmacopoeia (ph. eur.)pharmacopoeial standards. Alternative Names: 2,6,10,15,19,23-Hexamethyltetracosane, perhydrosqualene,Squalane.
Squalane-d62
Isotope labelled Squalane is used as an emollient and moisturizer in cosmetic applications. Group: Biochemicals. Grades: Highly Purified. CAS No. 16514-83-3. Pack Sizes: 10mg, 25mg. Molecular Formula: C30D62, Molecular Weight: 485.2. US Biological Life Sciences.
Worldwide
Squalane NF
2,6,10,15,19,23-Hexamethyltetraccosane. health foods. Grades: NF. CAS No. 111-01-3. Product ID: 1-01080. Molecular formula: C30H62. Mole weight: 422.82. Properties: >99.5%.
2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetraccosene. cosmetic and pharmaceutical excipient. CAS No. 111-02-4. Product ID: 1-01081. Molecular formula: C30H50. Mole weight: 410.73. Purity: 0.998. Properties: iodine value 0.01.
Squalene
Squalene - Product ID: NST-10-137. Category: Triterpens. Alternative Names: (E,E,E,E)-Squalene, all-trans-Squalene, Spinacen, Squalen, trans-Squalene. Purity: 98%. Test method: GC. CAS No. 111-02-4. Pack Sizes: 50g, 100g, 250g, 500g. Appearance: Colourless to light yellow liquid. Molecular formula: C30H50. Mole weight: 410.7. Storage: +2 +8 °C.
Squalene
Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Super Squalene; trans-Squalene; AddaVax. CAS No. 111-02-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1214.
Squalene
Squalene. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10g, 25g, 50g. US Biological Life Sciences.
Squalene 2,3:22,23-Dioxide is formed from he epoxidation of 2,3-oxidosqualene, by squalene epoxidase. Squalene 2,3:22,23-Dioxide is accumulated intracellularly during the inhibition of cholesterol biosynthesis in Chinese hamster ovary cells. Group: Biochemicals. Alternative Names: 2,3:22,23-Dioxidosqualene; Squalene 2,3:22,23-Diepoxide; (all-E)-2,3:22,23-Diepoxy-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraene; 2,2'-(3,7,12,16-Tetramethyl-3,7,11,15-octadecatetraene-1,18-diyl)bis[3,3-dimethyl-oxirane]. Grades: Highly Purified. CAS No. 31063-19-1. Pack Sizes: 25mg. Molecular Formula: C30H50O2, Molecular Weight: 442.72. US Biological Life Sciences.
Worldwide
squalene-hopanol cyclase
The enzyme produces the cyclization products hopene (cf. EC 5.4.99.17) and hopanol from squalene at a constant ratio of 5:1. Group: Enzymes. Synonyms: squalene-hopene cyclase (ambiguous). Enzyme Commission Number: EC 4.2.1.129. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4970; squalene-hopanol cyclase; EC 4.2.1.129; squalene-hopene cyclase (ambiguous). Cat No: EXWM-4970.
squalene-hopene cyclase
The enzyme also produces the cyclization product hopan-22-ol by addition of water (cf. EC 4.2.1.129, squalene hopanol cyclase). Hopene and hopanol are formed at a constant ratio of 5:1. Group: Enzymes. Enzyme Commission Number: EC 5.4.99.17. CAS No. 76600-69-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5556; squalene-hopene cyclase; EC 5.4.99.17; 76600-69-6. Cat No: EXWM-5556.
squalene methyltransferase
Two isoforms differing in their specificity were isolated from the green alga Botryococcus braunii BOT22. TMT-1 gave more of the dimethylated form whereas TMT2 gave more of the monomethylated form. Group: Enzymes. Synonyms: TMT-1; TMT-2. Enzyme Commission Number: EC 2.1.1.262. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1867; squalene methyltransferase; EC 2.1.1.262; TMT-1; TMT-2. Cat No: EXWM-1867.
squalene monooxygenase
A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: squalene epoxidase; squalene-2,3-epoxide cyclase; squalene 2,3-oxidocyclase; squalene hydroxylase; squalene oxydocyclase; squalene-2,3-epoxidase. Enzyme Commission Number: EC 1.14.14.17. CAS No. 9029-62-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0914; squalene monooxygenase; EC 1.14.14.17; 9029-62-3; squalene epoxidase; squalene-2,3-epoxide cyclase; squalene 2,3-oxidocyclase; squalene hydroxylase; squalene oxydocyclase; squalene-2,3-epoxidase. Cat No: EXWM-0914.
Squalene (Standard)
Squalene (Standard) is the analytical standard of Squalene. This product is intended for research and analytical applications. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 111-02-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1214R.
squalene synthase
This microsomal enzyme catalyses the first committed step in the biosynthesis of sterols. The enzyme from yeast requires either Mg2+ or Mn2+ for activity. In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated. When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP). High concentrations of FPP inhibit the production of squalene but not of PSPP. Group: Enzymes. Synonyms: farnesyltransferase; presqualene-diphosphate synthase; presqualene synthase; squalene synthetase; farnesyl-diphosphate farnesyltransferase; SQS. Enzyme Commission Number: EC 2.5.1.21. CAS No. 9077-14-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2758; squalene synthase; EC 2.5.1.21; 9077-14-9; farnesyltransferase; presqualene-diphosphate synthase; presqualene synthase; squalene synthetase; farnesyl-diphosphate farnesyltransferase; SQS. Cat No: EXWM-2758.
Squalestatin A
It is a squalene synthase inhibitor produced by the strain of Phoma sp. C2932. It inhibits squalene synthase in mammalian (rat liver) and Candida albicans, and has a broad-spectrum antifungal effect. Synonyms: Zaragozic acid A; squalestatin 1; Squalestatin; L-erythro-L-glycero-D-altro-7-Trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 11-acetate 5-(4,6-dimethyl-2-octenoate), (5(2E,4S,6S),7S)-; L-erythro-L-glycero-D-altro-7-Trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 11-acetate 5-[(2E,4S,6S)-4,6-dimethyl-2-octenoate], (7S)-; Squalestatin S1. Grades: >98% by HPLC. CAS No. 142561-96-4. Molecular formula: C35H46O14. Mole weight: 690.73.
Squalestatin B
It is a squalene synthase inhibitor produced by the strain of Phoma sp. C2932. It inhibits squalene synthase in mammalian (rat liver) and Candida albicans, and has a broad-spectrum antifungal effect. Synonyms: L-erythro-L-glycero-D-altro-7-Trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 5-[(2E,4S,6S)-4,6-dimethyl-2-octenoate], (7S)-; L-erythro-L-glycero-D-altro-7-Trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 5-(4,6-dimethyl-2-octenoate), [5(2E,4S,6S),7S]-; Squalestatin 2; Squalestatin S2. CAS No. 142505-91-7. Molecular formula: C33H44O13. Mole weight: 648.70.
Squalestatin C
It is a squalene synthase inhibitor produced by the strain of Phoma sp. C2932. It inhibits squalene synthase in mammalian (rat liver) and Candida albicans, and has a broad-spectrum antifungal effect. Synonyms: L-erythro-L-glycero-D-altro-7-Trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 11-acetate, (7S)-; Squalestatin 3; Squalestatin H1. CAS No. 142505-92-8. Molecular formula: C25H30O13. Mole weight: 538.50.
Squarunkin A is an inhibitor of UNC119 chaperone protein-cargo interaction. It inhibits the binding of a myristoylated peptide representing the N-terminus of Src kinase to UNC119A with an IC50 value of 10?nm. It binds to UNC119 proteins in cell lysate and interferes with the activation of Src kinase. Synonyms: Ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)amino)cyclobut-1-en-1-yl)amino)piperidine-1-carboxylate hydrochloride. Grades: ≥98% by HPLC. CAS No. 2253744-55-5. Molecular formula: C25H32F3N5O4·HCl. Mole weight: 560.01.