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| Product | Description | |
|---|---|---|
| SR 144528 | SR 144528 is a cannabinoid (CB) receptor 2 inverse agonist with selectivity for CB2 over CB1 receptors. It antagonizes the inhibitory effects of the cannabinoid receptor agonist CP 55,940 on forskolin-stimulated adenylyl cyclase activity in cell lines permanently expressing the h CB2 receptor. It selectively blocks the mitogen-activated protein kinase activity induced by CP 55,940 in cell lines expressing h CB2. Synonyms: SR144528; SR-144528; 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethyl-2-bicyclo[2.2.1]heptanyl]pyrazole-3-carboxamide. Grades: ≥98%. CAS No. 192703-06-3. Molecular formula: C29H34ClN3O. Mole weight: 476.1. |  |
| SR15006 | SR15006 is a inhibitor of Krüppel-like factor 5 (KLF5). SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo. SR18662 significantly reduces growth and proliferation of colorectal cancer cells as compared with treatment with vehicle control, SR18662 showed improved efficacy in reducing the viability of multiple colorectal cancer cell lines. SR18662 treatment also reduces the expression of cyclins and components of the MAPK and WNT signaling pathways. Group: Inhibitors. Alternative Names: SR15006; SR-15006; SR 15006. CAS No. 2505001-54-5. Molecular formula: C16H20ClN3O4S. Mole weight: 385.86. Appearance: Solid powder. Purity: >98%. IUPACName: (E)-3- (3-chlorophenyl)-N- (2- (4- (methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide. Canonical SMILES: O=C (NCC (N1CCN (S (=O) (C)=O)CC1)=O)/C=C/C2=CC=CC (Cl)=C2. Catalog: ACM2505001545. |  |
| SR 1555 hydrochloride | SR 1555 is an inverse agonist of RORγ with IC50 value of 1 μM. It inhibits endogenous IL-17A gene expression in mouse splenocytes and suppresses differentiation of TH17 cells when cultured under TH17 polarizing conditions. It is effective against various autoimmune diseases. Synonyms: 1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethanone monohydrochloride. Grades: ≥98%. CAS No. 1386439-51-5. Molecular formula: C22H22F6N2O2·HCl. Mole weight: 496.88. | |
| SR 16584 | SR 16584 is a selective α3β4 nAChR antagonist (IC50 = 10.2 μM) with selectivity for α3β4 over α4β2 and α7 subtypes (Ki = 0.508, >100 and >100 μM, respectively). Synonyms: 1,3-Dihydro-1-(3-exo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indol-2-one. Grades: ≥98% by HPLC. CAS No. 1150153-86-8. Molecular formula: C17H22N2O. Mole weight: 270.37. | |
| SR 16584 | SR 16584. Group: Biochemicals. Alternative Names: 1,3-Dihydro-1-[(3-exo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indol-2-one. Grades: Highly Purified. CAS No. 1150153-86-8. Pack Sizes: 10mg. Molecular Formula: C17H22N2O, Molecular Weight: 270.37. US Biological Life Sciences. |  Worldwide |
| SR 1664 | SR 1664. Group: Biochemicals. Grades: Purified. CAS No. 1338259-05-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 1664 | SR 1664 is a PPARγ (peroxisome proliferator-activated receptor γ ) inhibitor. SR 1664 can block PPARγ by cyclin-dependent kinase 5 with an IC50 value of 80 nM and it does not exhibit agonist activity at the PPARγ receptor. Recent research shows that SR 1664 has anti-diabetic effects in obese mice. Uses: Antidiabetic activity. Synonyms: SR1664; SR-1664; SR 1664. (S)-4'-((2,3-dimethyl-5-((1-(4-nitrophenyl)ethyl)carbamoyl)-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid. Grades: 98%. CAS No. 1338259-05-4. Molecular formula: C33H29N3O5. Mole weight: 547.61. | |
| SR 16832 | SR 16832 is a dual-site covalent antagonist of PPARγ, acting at orthosteric and allosteric sites in the ligand binding domain. It inhibits MRL20-induced allosteric activation of PPARγ in a reporter assay using HEK293T cells when used at a concentration of 5 μM. Synonyms: 2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide. Grades: ≥98%. CAS No. 2088135-12-8. Molecular formula: C17H12ClN3O4. Mole weight: 357.75. | |
| SR 16832 | SR 16832 is a dual site covalent PPARγ inhibitor that acts at orthosteric and allosteric sites [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2088135-12-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112247. |  |
| SR17018 | SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC 50 of 97 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2134602-45-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111454. | |
| SR 17018 | SR 17018 is an orally bioavailable and brain-penetrant agonist of μ-opioid receptors (MOR). Synonyms: 5,6-Dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one. Grades: ≥98%. CAS No. 2134602-45-0. Molecular formula: C19H18Cl3N3O. Mole weight: 410.72. | |
| SR 18292 | SR 18292 is an inhibitor of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). It reduces blood glucose, potently increases hepatic insulin sensitivity, and improves glucose homeostasis in dietary and genetic mouse models of type 2 diabetes. Synonyms: 1-[Tert-butyl-[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)propan-2-ol. Grades: ≥95%. CAS No. 2095432-55-4. Molecular formula: C23H30N2O2. Mole weight: 366.5. | |
| SR18662 | SR18662 is an optimized anticancel agent based on ML264. SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo. SR18662 showed improved efficacy in reducing the viability of multiple colorectal cancer cell lines. Flow cytometry analysis following SR18662 treatment showed an increase in cells captured in either S or G2-M phases of the cell cycle and a significant increase in the number of apoptotic cells, the latter a unique property compared with ML264 or SR15006. SR18662 treatment also reduces the expression of cyclins and components of the MAPK and WNT signaling pathways. Group: Others. Alternative Names: SR18662; SR-18662; SR 18662. CAS No. 2505001-62-5. Molecular formula: C16H19Cl2N3O4S. Mole weight: 420.31. Appearance: Solid powder. Purity: >98%. IUPACName: (E)-3- (3, 4-dichlorophenyl)-N- (2- (4- (methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide. Canonical SMILES: O=C (NCC (N1CCN (S (=O) (C)=O)CC1)=O)/C=C/C2=CC=C (Cl)C (Cl)=C2. Catalog: ACM2505001625. | |
| SR 1903 | SR 1903 is an inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and an agonist of liver X receptor (LXR). It also binds to PPARγ without activity. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity. Synonyms: 1-[2'-Methyl-4'-[[4-(4-pyridylmethyl)-1-piperazinyl]methyl]-4-biphenylyl]-1-(trifluoromethyl)-2,2,2-trifluoroethanol. Grades: ≥98%. CAS No. 1414248-06-8. Molecular formula: C27H27F6N3O. Mole weight: 523.51. | |
| SR 202 | SR 202 is a selective PPARγ antagonist used as an antidiabetic and antiobesity agent. SR 202 inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo, improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo. Synonyms: Mifobate; SR 202; SR-202; SR202; (4-Chlorophenyl) (dimethoxyphosphinyl)methyl phosphoric acid dimethyl ester; Mifobate; Clenicor. Grades: ≥99% by HPLC. CAS No. 76541-72-5. Molecular formula: C11H17ClO7P2. Mole weight: 358.65. | |
| SR 202 | SR 202. Group: Biochemicals. Grades: Purified. CAS No. 76541-72-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 2211 | SR 2211 is a selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). SR 2211 exhibits weak activity at liver X receptor α (LXRα) and has no effect on transcriptional activity of farnesoid X receptors (FXR) or transcriptional activity of ROR&alpha. Synonyms: SR-2211; SR2211;SR 2211; 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol; 1,1,1,3,3,3-hexafluoro-2-[3-fluoro-4-[4-[[4-(pyridin-4-ylmethyl)piperazin-1-yl]methyl]phenyl]phenyl]propan-2-ol. Grades: ≥98% by HPLC. CAS No. 1359164-11-6. Molecular formula: C26H24F7N3O. Mole weight: 527.48. | |
| SR 2595 | SR 2595 is an inverse agonist of PPARγ (IC50 = 30 nM) that represses both transactivation in a promoter:reporter assay and expression of the adipogenic marker fatty acid-binding protein 4 in differentiating murine preadipocytes. Synonyms: 2-[4-[[5-[[(1S)-1-(4-Tert-butylphenyl)ethyl]carbamoyl]-2,3-dimethylindol-1-yl]methyl]phenyl]benzoic acid. Grades: ≥98%. CAS No. 1415252-61-7. Molecular formula: C37H38N2O3. Mole weight: 558.7. | |
| SR 2640 hydrochloride | SR 2640 hydrochloride is a potent and selective competitive leukotriene D4 and E4 receptor antagonist. SR 2640 has been shown to inhibit LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). It also inhibits LTD4-attenuation of human PMN chemotaxis. Synonyms: SR 2640 hydrochloride; SR2640 hydrochloride; SR-2640 hydrochloride; 2-[[3- (2-Quinolinylmethoxy) phenyl]amino]benzoic acid hydrochloride. Grades: ≥99% by HPLC. CAS No. 146662-42-2. Molecular formula: C23H18N2O3.HCl. Mole weight: 406.87. | |
| SR 2640 Hydrochloride | Potent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4- attenuation of human PMN chemotaxis. Group: Biochemicals. Alternative Names: 2-[[3- (2-Quinolinylmethoxy) phenyl]amino]benzoic acid hydrochloride. Grades: Highly Purified. CAS No. 146662-42-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 27897 | SR 27897. Group: Biochemicals. Grades: Purified. CAS No. 136381-85-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 27897 | SR 27897 is a potent and non-peptide CCK1 receptor antagonist displaying > 33-fold selectivity over CCK2 receptors (EC50 = 6 and 200 nM, respectively). It was shown to increase plasma leptin levels and promote food intake in rats in vivo. SR 27897 is used for the treatment of pancreatic cancer. Uses: The treatment of pancreatic cancer. Synonyms: SR-27897; SR27897; SR 27897; 2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid; Lintitript. Grades: ≥99% by HPLC. CAS No. 136381-85-6. Molecular formula: C20H14ClN3O3S. Mole weight: 411.86. | |
| SR-3029 | SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with potent antiproliferative properties SR-3029 shoed IC50:= 97 nM in MTT assays against the human A375 melanoma cell line and have physical, in vitro and in vivo PK properties suitable for use in proof of principle animal xenograft studies against human cancer cell lines. Group: Inhibitors. Alternative Names: SR-3029; SR 3029; SR3029. CAS No. 1454585-06-8. Molecular formula: C23H19F3N8O. Mole weight: 480.46. Appearance: Solid powder. Purity: >98%. IUPACName: (6,7-Difluoro-1H-benzoimidazol-2-ylmethyl)-[9-(3-fluoro-phenyl)-2-morpholin-4-yl-9H-purin-6-yl]-amine. Canonical SMILES: FC1=CC (N2C=NC3=C (NCC4=NC5=CC=C (F)C (F)=C5N4)N=C (N6CCOCC6)N=C23)=CC=C1. Catalog: ACM1454585068. | |
| SR-3029 | SR-3029, a small molecule inhibitor that targets specificly CK1δ/CK1ε, was effective at reducing the growth of breast cancer in multiple mouse models without any signs of major toxicity. IC50=97 nM. Synonyms: N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-morpholin-4-ylpurin-6-amine;SR-3029; SR 3029; SR3029;SCHEMBL15243359; SCHEMBL17132207; CS-5672; CS 5672; CS5672; HY-100011; 1454585-06-8. CAS No. 1454585-06-8. Molecular formula: C23H19F3N8O. Mole weight: 480.45. | |
| SR-31747 | SR-31747 is a new sigma ligand, which elicited a suppressive effect on immune responses through the sigma receptor expressed on lymphocytes. Synonyms: N-Cyclohexyl-N-ethyl-3-(3-chloro-4-cyclohexylphenyl)propen-2-ylamine hydrochloride; SR 31747 HCl. Grades: 98%. CAS No. 132173-07-0. Molecular formula: C23H35Cl2N. Mole weight: 396.44. | |
| SR-31747 | SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 132173-07-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13751. | |
| SR-3306 | SR-3306, an aminopyrimidine derivative, is a JNK Inhibitor and could be mainly active in Phosphorylation & Dephosphorylation actions. Uses: Sr-3306 is a jnk inhibitor and could be mainly active in phosphorylation & dephosphorylation actions. Synonyms: SR-3306; SR-3306; SR-3306. Grades: 98%. CAS No. 1128096-91-2. Molecular formula: C28H26N8O. Mole weight: 490.56. | |
| SR3335 | The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles. SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM). It has no effect on RORβ, RORγ, farnesoid X receptor, or liver X receptor &alpha. SR 3335 evokes RORα-dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis. Synonyms: ML-176; SR 3335; SR-3335; ML176; ML 176. Grades: >98%. CAS No. 293753-05-6. Molecular formula: C13H9F6NO3S2. Mole weight: 405.34. | |
| SR33805 | SR33805 is a potent Ca 2+ channel antagonist, with EC 50 s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca 2+ channels. SR33805 can be used for the research of acute or chronic failing hearts [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 121345-64-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-136909. | |
| SR 33805 oxalate | SR 33805 oxalate is a potent Ca2+ channel antagonist that binds allosterically to the a1-subunit of L-type Ca2+ channels (Kd = 20 pM). SR 33805 displays selectivity for vascular smooth muscle, inducing vasorelaxation with no inotropic or chronotropic effects. It exhibits an inhibitory effect on PDGF-stimulated smooth muscle cell proliferation. Synonyms: SR 33805 oxalate; SR33805 oxalate; SR-33805 oxalate; 3, 4-Dimethoxy-N-methyl-N- [3- [4- [ [1-methyl-3- (1-methylethyl) -1H-indol-2-yl] sulfonyl] phenoxy] propyl] benzeneethanamine. Grades: ≥99% by HPLC. CAS No. 121346-33-6. Molecular formula: C32H40N2O5S.C2H2O4. Mole weight: 654.77. | |
| SR 33805 oxalate | SR 33805 oxalate. Group: Biochemicals. Grades: Purified. CAS No. 121346-33-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SR 3576 | SR 3576. Group: Biochemicals. Grades: Purified. CAS No. 1164153-22-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 3576 | SR 3576 is a potent and selective JNK3 inhibitor (IC50 = 7 nM) with > 2800-fold selectivity over p38. Synonyms: SR-3576; SR 3576; SR3576; 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide; JNK3 Inhibitor XII; SR-3576; Aminopyrazole inhibitor, 3576. Grades: ≥97% by HPLC. CAS No. 1164153-22-3. Molecular formula: C27H27N5O5. Mole weight: 501.53. | |
| SR-3576 | Heterocyclic Organic Compound. Alternative Names: Aminopyrazole inhibitor, 3576, SR-3576, 3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide, 1164153-22-3, 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide. CAS No. 1164153-22-3. Molecular formula: C27H27N5O5. Mole weight: 501.53. Purity: 0.96. IUPACName: 3-[4-[(3-methylphenyl)carbamoylamino]pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide. Canonical SMILES: CC1=CC (=CC=C1)NC (=O)NC2=CN (N=C2)C3=CC=CC (=C3)C (=O)NC4=CC (=C (C (=C4)OC)OC)OC. Catalog: ACM1164153223. | |
| SR 3677 | SR 3677 is an effective ROCK inhibitor, espectially against ROCK II and it could block the phosphorylation ofmyosin light chain and promote the outflow of aqueous humor in porcine eyes in ex-vivo study. And it was also found to have the potential use to p. Uses: Sr 3677 is an effective rock inhibitor, espectially against rock ii and it could block the phosphorylation ofmyosin light chain and promote the outflow of aqueous humor in porcine eyes in ex-vivo study. Synonyms: N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide;SR 3677 hydrochloride;SR3677; SR-3677; SR 3677. Grades: >98 %. CAS No. 1072959-67-1. Molecular formula: C22H24N4O4. Mole weight: 408.45. | |
| SR 3677 dihydrochloride | SR 3677 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1072959-67-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 4370 | SR 4370 is an inhibitor of HDAC. Synonyms: N'-butyl-4-(2,3-difluorophenyl)benzohydrazide. CAS No. 1816294-67-3. Molecular formula: C17H18F2N2O. Mole weight: 304.33. | |
| SR4554 | SR4554 is a fluorine-containing 2-nitroimidazole, designed as a hypoxia marker detectable with 19F magnetic resonance spectroscopy (MRS). SR-4554 has plasma pharmacokinetic and toxicity profiles suitable for use as a hypoxia probe. It can be detected in tumors by unlocalized MRS. Additional clinical studies are warranted. Synonyms: SR-4554; SR 4554; N-(2-Hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl)acetamide. CAS No. 167648-73-9. Molecular formula: C8H9F3N4O4. Mole weight: 282.18. | |
| SR-4835 | SR-4835 Inhibitor. Uses: Scientific use. Product Category: T8325. CAS No. 2387704-62-1. |  |
| SR 48692 | SR 48692. Group: Biochemicals. Grades: Purified. CAS No. 146362-70-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 49059 | SR 49059. Group: Biochemicals. Grades: Purified. CAS No. 150375-75-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SR 49059 | SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a K i vaule of 1.4 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 150375-75-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18345. | |
| SR 57227A | SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC 50 ) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 77145-61-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-102064. | |
| SR 57227A hydrochloride | SR 57227 hydrochloride is a selective and high affinity 5-HT3 receptor agonist. SR 57227 exhibits anti-depressant like effects and decreases isolation-induced aggressive behavior in rat model. Synonyms: SR 57227A hydrochloride; SR57227A hydrochloride; SR-57227A hydrochloride; 1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride; 4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride. Grades: ≥99% by HPLC. CAS No. 77145-61-0. Molecular formula: C10H14ClN3.HCl. Mole weight: 248.15. | |
| SR 57227 hydrochloride | SR 57227 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 77145-61-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR-58611 | Heterocyclic Organic Compound. Alternative Names: (7S)-5, 6, 7, 8-Tetrahydro-7-[[ (R)-2-hydroxy-2- (3-chlorophenyl)ethyl]amino]-2-[ (ethoxycarbonyl)methoxy]naphthalene; SR-58611; SR-58825A; amibegron. CAS No. 121524-08-1. Molecular formula: C22H26ClNO4. Purity: 0.96. IUPACName: ethyl 2-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]acetate. Canonical SMILES: CCOC (=O)COC1=CC2=C (CCC (C2)NCC (C3=CC (=CC=C3)Cl)O)C=C1. Catalog: ACM121524081. | |
| SR 58611A hydrochloride | SR 58611A hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 121524-09-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 58611A hydrochloride | SR 58611A hydrochloride is a selective and brain penetrating β3-adrenergic receptor agonist that exhibits anxiolytic and antidepressant effects in rodent models. Uses: Adrenergic beta-3 receptor agonists. Synonyms: SR 58611A hydrochloride; SR58611A hydrochloride; SR-58611A hydrochloride; [[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]ox]yacetic acid ethyl ester hydrochloride; Amibegron hydrochloride; Amibegron HCl. Grades: ≥98% by HPLC. CAS No. 121524-09-2. Molecular formula: C22H26ClNO4.HCl. Mole weight: 440.36. | |
| SR 59230A hydrochloride | SR 59230A hydrochloride is a potent, selective and orally available β3 adrenoceptor antagonist (IC50 = 40, 408 and 648 nM for β3, β1 and β2 receptors, respectively). SR 59230A blocks MDMA-induced hyperthermia at low concentrations, while it blocks hyperthermia and also increases heat loss through an α1-AR antagonistic mechanism at high concentrations. Synonyms: SR 59230A hydrochloride; SR59230A hydrochloride; SR-59230A hydrochloride; 1-(2-Ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol hydrochloride; (2S)-1-(2-ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]propan-2-ol hydrochloride. Grades: ≥98% by HPLC. CAS No. 1135278-41-9. Molecular formula: C21H27NO2.HCl. Mole weight: 361.91. | |
| SR 59230A hydrochloride | SR 59230A hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1135278-41-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR-717 | SR-717 Inhibitor. Uses: Scientific use. Product Category: T8655. CAS No. 2375421-09-1. | |
| SR-717 lithium | SR-717 is an agonist of stimulator of interferon genes STING for treating cancer. SR-717 demonstrates broad interspecies and interallelic specificity. SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. Group: Agonists. Alternative Names: SR-717 lithium; SR 717 lithium; SR717 lithium. CAS No. 2375421-09-1. Molecular formula: C15H8F2LiN5O3. Mole weight: 351.2. Appearance: Solid powder. Purity: >98%. IUPACName: lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate. Canonical SMILES: O=C ([O-])C1=CC (F)=C (F)C=C1NC (C2=NN=C (N3C=CN=C3)C=C2)=O. [Li+]. Catalog: ACM2375421091. | |
| SR-717 lithium | SR-717 is an agonist of stimulator of interferon genes (STING) for treating cancer. Synonyms: SR 717 lithium; SR717 lithium. Grades: >98%. CAS No. 2375421-09-1. Molecular formula: C15H8F2LiN5O3. Mole weight: 351.2. | |
| SR 7826 | SR 7826 is a potent and selective LIMK inhibitor (IC50 = 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). SR 7826 was shown to inhibit cofilin phosphorylation in A7r5 cells and suppress migration and invasion of PC-3 cells in vitro. Synonyms: SR7826; SR-7826; SR 7826; N-(2-Hydroxyethyl)-N'-[4,5-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)phenyl]-N-phenylurea; 1-(2-hydroxyethyl)-3-[4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-phenylurea. Grades: ≥98% by HPLC. CAS No. 1219728-20-7. Molecular formula: C22H21N5O2. Mole weight: 387.43. | |
| SR8278 | SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC 50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1254944-66-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14415. | |
| SR8278 | Heterocyclic Organic Compound. Alternative Names: SR8278, 1254944-66-5, KB-80725, 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester, ethyl 2-{[5-(methylsulfanyl)thiophen-2-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylate. CAS No. 1254944-66-5. Molecular formula: C18H19NO3S2. Mole weight: 361.48. Purity: 0.96. IUPACName: ethyl 2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate. Canonical SMILES: CCOC (=O)C1CC2=CC=CC=C2CN1C (=O)C3=CC=C (S3)SC. Catalog: ACM1254944665. | |
| SR 8278 | SR 8278 is a nuclear heme receptor Rev-Erbα antagonist. This compound inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM) and blocks activity of Rev-Erbα agonist GSK 4112 in HEK293 cells. SR 8278 increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells. Synonyms: SR8278; SR 8278; SR-8278. 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester; ethyl 2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate. Grades: ≥99% by HPLC. CAS No. 1254944-66-5. Molecular formula: C18H19NO3S2. Mole weight: 361.48. | |
| SR 8278 | SR 8278. Group: Biochemicals. Alternative Names: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 1254944-66-5. Pack Sizes: 10mg. Molecular Formula: C18H19NO3S2, Molecular Weight: 361.48. US Biological Life Sciences. | Worldwide |
| SR9009 | SR9009 is a REV-ERBα/β agonist with IC 50 s of 670 nM and 800 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1379686-30-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16989. | |
| SR9011 | SR9011 is a REV-ERBα / β agonist with IC 50 s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1379686-29-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16988. | |
| SR9011 | SR9011, a synthetic REV-ERB agonist, has been found to have probable effect against sleep disorders and metabolic diseases. IC50: 790 nM and 560 nM for Rev-ErbBα and Rev-ErbBβ respectively. Synonyms: SR 9011; SR-9011; 1-Pyrrolidinecarboxamide, 3-((((4-chlorophenyl)methyl)((5-nitro-2-thienyl)methyl)amino)methyl)-n-pentyl-. Grades: 98%. CAS No. 1379686-29-9. Molecular formula: C23H31ClN4O3S. Mole weight: 479.04. | |
| SR9011 hydrochloride | SR9011 hydrochloride is a REV-ERBα / β agonist with IC 50 s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070014-94-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16988A. | |
| SR 9186 | SR 9186 is an inhibitor of the cytochrome P450 isoform CYP3A4 with IC50 value of 0.011 μM. Synonyms: 1-[4-(4-Cyanophenyl)phenyl]-3-[4-(1H-imidazo[4,5-b]pyridin-7-yl)phenyl]urea. Grades: ≥95%. CAS No. 1361414-26-7. Molecular formula: C26H18N6O. Mole weight: 430.5. | |
| SR 9238 | SR 9238 is a potent and selective LXR inverse agonist (IC50 = 43 and 214 nM for LXRβ and LXRα, respectively) with selectivity over a panel of 20 other nuclear receptors, including FXR. SR 9238 exhibits little activity at peripheral LXR. SR 9238 has been shown to reduce hepatic steatosis in obese mice. Synonyms: SR9238; SR 9238; SR-9238; Ethyl 5-[[[[3'- (Methylsulfonyl) [1, 1'-biphenyl]-4-yl]methyl][ (2, 4, 6-trimethylphenyl) sulfonyl]amino]methyl]-2-furancarboxylate. Grades: ≥98% by HPLC. CAS No. 1416153-62-2. Molecular formula: C31H33NO7S2. Mole weight: 595.73. | |
| SR9243 | SR9243 is a potent and selective LXR inverse agonist. SR9243 kills cancer cells by inhibiting lipid production and the Warburg effect. Synonyms: SR9243; SR-9243; SR 9243. Grades: 98%. CAS No. 1613028-81-1. Molecular formula: C31H32BrNO4S2. Mole weight: 626.62. | |
| SR95531 (Gabazine, GABAA Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531) | A selective, competitive antagonist of GABAA receptor (IC50 = 440nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100uM). Also shown to block glycine receptors, but with low affinity (Kb = 190uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 104104-50-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SR 95531 hydrobromide | SR 95531 hydrobromide is a competitive GABAA receptor antagonist. SR 95531 differs from bicuculline that it selectively antagonizes GABA-induced Cl- currents but exhibits little action on pentobarbitone-induced currents. SR 95531 also acts as a low affinity glycine receptor antagonist. Uses: Gaba antagonists. Synonyms: SR 95531 hydrobromide; SR95531 hydrobromide; SR-95531 hydrobromide; 4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid hydrobromide; 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide; Gabazine hydrobromide. Grades: ≥98% by HPLC. CAS No. 104104-50-9. Molecular formula: C15H17N3O3.HBr. Mole weight: 368.23. | |
| SR 95531 hydrobromide | SR 95531 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 104104-50-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SRC-3-IN-2 | SRC-3-IN-2 (SI-12 6c)is an orally active steroid receptor coactivator 3 ( SRC-3 ) inhibitor. SRC-3-IN-2 has antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3074959-44-4. Pack Sizes: 1 mg. Product ID: HY-163469. | |
| Src I1 | Src I1. Group: Biochemicals. Grades: Purified. CAS No. 179248-59-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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