A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
SPA70 is a potent and selective antagonist of human pregnane X receptor (hPXR), with an IC50 of 540 nM (Ki=390 nM). SPA70 can enhance the chemosensitivity of cancer cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 931314-31-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124830.
SPACE peptide
SPACE peptide is a skin penetrating peptide which can enhance topical delivery of a macromolecule, hyaluronic acid and facilitates the delivery of molecules through the skin. Molecular formula: C40H63N15O17S2. Mole weight: 1090.17.
Spacer C12 CE Phosphoramidite
Spacer phosphoramidites C3, 9, and 18 are used to insert spacer arms in oligonucleotides. When a longer spacer is required, the compound can be added multiple times. Synonyms: 3-[12-[bis (4-methoxyphenyl) -phenylmethoxy]dodecoxy-[di (propan-2-yl) amino]phosphanyl]oxypropanenitrile. Grades: >95% by HPLC. CAS No. 158665-27-1. Molecular formula: C42H61N2O5P. Mole weight: 704.93.
Spacer Phosphoramidite 18
Spacer phosphoramidites 18 is used to insert a spacer arm in an oligonucleotide and may be added in multiple additions when a longer spacer is required. Synonyms: 1,1-Bis(4-methoxyphenyl)-1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-yl (2-cyanoethyl) diisopropylphosphoramidite. Grades: >95% by HPLC. Molecular formula: C42H61N2O10P. Mole weight: 784.93.
Spacer Phosphoramidite 9
Spacer phosphoramidites 9 is used to insert a spacer arm in an oligonucleotide and may be added in multiple additions when a longer spacer is required. Synonyms: 9-O-Dimethoxytrityl-triethylene glycol,1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Grades: >95% by HPLC. CAS No. 146668-73-7. Molecular formula: C36H49N2O7P. Mole weight: 652.77.
Sp-Adenosine 3',5'-cyclic monophosphorothioate triethylammonium salt
Sp-Diastereomer of adenosine 3',5'-cyclic monophosphorothioate is a potent, membrane-permeable activator of PKA (cAMP dependent protein kinase I and II). Mimics the effects of cAMP as a second messenger in numerous systems while being resistant to cyclic nucleotide phosphodiesterases. Exhibits greater specificity and affinity than forskolin and cAMP analogs such as dibutyryl-cAMP. Sp-Adenosine 3',5'-cyclic monophosphorothioate triethylammonium salt hydrate is an activator of Epac. Applications: A membrane permeable activator of camp dependent protein kinase i and ii. Group: Coenzymes. Synonyms: Sp-Cyclic 3',5'-hydrogen phosphorothioate adenosine; Sp-cAMPS triethylammonium salt. CAS No. 93602-66-5. Purity: ≥98%. Mole weight: 446.46. Form: Solid. Sp-Cyclic 3',5'-hydrogen phosphorothioate adenosine; Sp-cAMPS triethylammonium salt; Sp-Adenosine 3',5'-cyclic monophosphorothioate triethylammonium salt; 93602-66-5. Cat No: COEC-116.
Sp-Adenosine 3?,5?-cyclic monophosphorothioate triethylammonium salt hydrate
Spadin, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with IC 50 value of 10 nM. Spadin enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin can be used for antidepressant research [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1270083-24-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1422.
Spadin
Spadin is a potent and brain penetrating TREK-1 channel blocker (IC50 = 71 nM) displaying antidepressant activity. Spadin enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis in adult mice. Synonyms: Spadin; 1270083-24-3; Spadin (trifluoroacetate salt); HB5438; AKOS025293510; C96H142N26O22; S-1270083-24-3. CAS No. 1270083-24-3. Molecular formula: C96H142N26O22. Mole weight: 2012.34.
Spaglumic Acid is a peptide neurotransmitter and the third-most-prevalent neurotransmitter in the mammalian nervous system. NAAG consists of N-acetylaspartic acid and glutamic acid coupled via a peptide bond. Spaglumic Acid alsp acts as an NMDA receptor activator and mGlu3 receptor agonist. Synonyms: N-Acetyl-L-aspartyl-L-glutamic acid; Isospaglumic acid; NAAG; N-Acetyl-Asp-Glu; N-acetylaspartylglutamate. Grades: ≥96% by HPLC. CAS No. 3106-85-2. Molecular formula: C11H16N2O8. Mole weight: 304.26.
Spaglumic Acid-d3
Spaglumic Acid-d3 is the isotope labelled analogue of Spaglumic Acid, a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments. Group: Biochemicals. Alternative Names: N-Acetyl-L-α-aspartyl-L-glutamic Acid-d3; N-(N-Acetyl-L-α-aspartyl)-L-glutamic Acid-d3; Acetyl-α-L-aspartylglutamic Acid-d3; Isospaglumic Acid-d3; N- (N-Acetylaspartyl) glutamic Acid-d3; N-Acetyl-L-aspartyl-L-glutamic Acid-d3; N-Acetyl-α-L-aspartyl-L-glutamic Acid-d3; N-Acetyl-α-aspartylglutamic Acid-d3; N-Acetylaspartylglutamic Acid-d3; NAAG-d3; α-Spaglumic Acid-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Span 20
Span 20. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Sorbitan monolaurate; Arlasel 20. Product Category: Non-ionic Surfactants. Appearance: Amber oil. CAS No. 1338-39-2. Molecular formula: C18H34O6. Mole weight: 346.46. IUPACName: [2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate. Density: 1.032 g/mL at 25 °C (lit.). ECNumber: 215-663-3. Product ID: ACM1338392. Alfa Chemistry ISO 9001:2015 Certified.
Span 20
Span 20. CAS No. 1338-39-2. Product ID: PE-0040. Molecular formula: C18H34O6. Mole weight: 346.459. Category: Emulsifier Excipients. Product Keywords: Pharmaceutical Excipients; Liquid Dosage Form; Semi-solid Dosage Form; Suppository Bases;Micro-drug Delivery Systems; Emulsifier Excipients; Span 20; PE-0040; C18H34O6; 1338-39-2; 1338-39-2. Appearance: Clear, colorless liquid. Purity: 0.9999. Storage: Keep tightly closed in a cool place in a tightly closed container. Boiling Point: 516.1°C at 760mmHg. Density: 1.032 g/cm3.
Sorbitan monostearate is an ester of sorbitan (a sorbitol derivative) and stearic acid and is sometimes referred to as a synthetic wax. It is primarily used as an emulsifier to keep water and oils mixed. Sorbitan monostearate is used in the manufacture of food and healthcare products and is a non-ionic surfactant with emulsifying, dispersing, and wetting properties. It is also employed to create synthetic fibers, metal machining fluid, and brighteners in the leather industry, and as an emulsifier in coatings, pesticides, and various applications in the plastics, food and cosmetics industries. CAS No. 1338-41-6. Product ID: PE-0042. Molecular formula: C24H46O6. Mole weight: 430.618. Category: Emulsifier Excipients. Product Keywords: Pharmaceutical Excipients; Liquid Dosage Form; Semi-solid Dosage Form; Suppository Bases;Micro-drug Delivery Systems; Emulsifier Excipients; Span 60; PE-0042; C24H46O6; 1338-41-6; 1338-41-6. Appearance: Cream color flake. EC Number: 215-664-9. Synonym(s): Span(rg 60;Lonzest(R) SMS;ARLACEL 60;SPAN(R) 60;(Sorbitan Monostearate). Storage: Store in a dry, cool and well-ventilated place, away from direct sunlight. Keep containers closed when not in use. Boiling Point: 579ºC at 760 mmHg. Melting Point: 54-57ºC. Density: 1.056 g/cm3.
Sorbitan monostearate is an ester of sorbitan (a sorbitol derivative) and stearic acid and is sometimes referred to as a synthetic wax. It is primarily used as an emulsifier to keep water and oils mixed. Sorbitan monostearate is a non-ionic surfactant with emulsifying, dispersing, and wetting properties. Uses: Sorbitan monooctadecanoate can be used as an excipient, such as emulsifiers, nonionic surfactants, solubilizers, as well as wetting and dispersing/suspending agents. Additional or Alternative Names: Arlacel 60. Product Category: Non-ionic Surfactants. Appearance: White to light yellow powder. CAS No. 1338-41-6. Molecular formula: C24H46O6. Mole weight: 430.62. IUPACName: [2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] octadecanoate. Canonical SMILES: CCCCCCCCCCCCCCCCCC(=O)OCC(C1C(C(CO1)O)O)O. Density: 1.1±0.1 g/mL. ECNumber: 215-664-9. Product ID: ACM1338416-3. Alfa Chemistry ISO 9001:2015 Certified.
Sorbitan monooleate is a renewable polyol with unique molecular structures for the development and design of bio-based waterborne polyurethane (WPU) with versatility and excellent mechanical properties. Uses: Sorbitan monooleate can be used as an excipient, such as nonionic surfactants, emulsifiers. pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Additional or Alternative Names: Sorbitan monooleate. Product Category: Non-ionic Surfactants. Appearance: Yellow to amber liquid. CAS No. 1338-43-8. Molecular formula: C24H44O6. Mole weight: 428.6. IUPACName: [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (Z)-octadec-9-enoate. Canonical SMILES: CCCCCCCCC=CCCCCCCCC(=O)OCC(C1C(C(CO1)O)O)O. Density: 1.1±0.1 g/mL. ECNumber: 215-665-4. Product ID: ACM1338438-3. Alfa Chemistry ISO 9001:2015 Certified.
Spantide I
Spantide I is a selective NK1 receptor antagonist (Ki = 230, 8150 and > 10000 nM for rat NK1, NK2 and NK3 receptors, respectively). Uses: Analgesics. Synonyms: [D-Arg1, D-Trp7,9, Leu11]-Substance P. CAS No. 91224-37-2. Molecular formula: C75H108N20O13. Mole weight: 1497.79.
Spantide I
Spantide I, a substance P analog, is a selective NK 1 receptor antagonist, with K i values of 230 nM and 8150 nM for NK 1 and NK 2 receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 91224-37-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1194.
Spantide II
Spantide II is more effective as an antagonist of substance P than spantide I, but less effective in releasing histamine from mast cells. The neurotoxicity of Spantide II is negligible. Uses: Analgesics. Synonyms: (D-Lys(nicotinoyl)1,β-(3-pyridyl)-Ala3,3,4-dichloro-D-Phe5,Asn6,D-Trp7,9,Nle11)-Substance P; H-D-Lys(nicotinoyl)-Pro-β-(3-pyridyl)-Ala-Pro-3,4-dichloro-D-Phe-Asn-D-Trp-Phe-D-Trp-Leu-Nle-NH2; L-Norleucinamide, N6-(3-pyridinylcarbonyl)-D-lysyl-L-prolyl-3-(3-pyridinyl)-L-alanyl-L-prolyl-3,4-dichloro-D-phenylalanyl-L-asparaginyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-. Grades: 95%. CAS No. 129176-97-2. Molecular formula: C86H104Cl2N18O13. Mole weight: 1668.79.
recombinant, expressed in CHO cells, ?97% (SDS-PAGE), ?97% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Sparfloxacin
A fluorianted quinolone antibacterial. Group: Biochemicals. Grades: Highly Purified. CAS No. 110871-86-8. Pack Sizes: 10mg, 100mg, 500mg, 1g. Molecular Formula: C19H22F2N4O3, Melting Point: >245°C (dec.). US Biological Life Sciences.
Worldwide
Sparfloxacin
5g Pack Size. Group: Antibiotics, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C19H22F2N4O3. CAS No. 110871-86-8. Prepack ID 48237696-5g. Molecular Weight 392.4. See USA prepack pricing.
Sparfloxacin
Sparfloxacin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-AMINO-1-CYCLOHEXYL-7-(CIS-3,5-DIMETHYLPIPERAZINO)-6,8-DIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACID;,5-dimethyl-1-piperazinyl)-4-oxo-,cis-;at4140;ci978;Clorsulon, Vetranal;SPARFLOXACIN, [2-14C]- 5-25 MCI(185-925 MBQ)/MMOL, DELIVERED >5-amino-1-cyclohexyl-7-(cis-3,5-dimethylpiperazino)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-, cis-. Product Category: Heterocyclic Organic Compound. CAS No. 110871-86-8. Molecular formula: C19H22F2N4O3. Mole weight: 392.4. Product ID: ACM110871868. Alfa Chemistry ISO 9001:2015 Certified.
Sparfloxacin
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI-978; AT-4140. CAS No. 110871-86-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0308.
Sparfloxacin
Sparfloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity. It can inhibit bacterial DNA gyrase, thereby inhibiting DNA replication and transcription. Uses: Antitubercular agents. Synonyms: Zagam; AT-4140. Grades: >98%. CAS No. 110871-86-8. Molecular formula: C19H22F2N4O3. Mole weight: 392.40.
Sparfosic acid trisodium
Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis. Sparfosic acid trisodium synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 70962-66-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112732B.
Sparoxomycin A1
It is produced by the strain of Str. sparsogenes SN 2325. It is a novel mammalian cell proliferation effector that converts the transformed phenotype of Rous sarcoma virus-infected NRK cells to a normal phenotype. Synonyms: 2-Propenamide, N-[(1S)-1-(hydroxymethyl)-2-[[S(R)]-[[[S(S)]-methylsulfinyl]methyl]sulfinyl]-ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (2E)-. CAS No. 174390-01-3. Molecular formula: C13H19N3O6S2. Mole weight: 377.44.
Sparoxomycin A2
It is produced by the strain of Str. sparsogenes SN 2325. It is a novel mammalian cell proliferation effector that converts the transformed phenotype of Rous sarcoma virus-infected NRK cells to a normal phenotype. It has weak antimicrobial activity (such as Escherichia coli) but has no effect on staphylococcus aureus, candida albicans and staphylococcus grayi. Synonyms: 2-Propenamide, N-[(1S)-1-(hydroxymethyl)-2-[[S(R)]-[[[S(R)]-methylsulfinyl]methyl]sulfinyl]-ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (2E)-. CAS No. 174390-02-4. Molecular formula: C13H19N3O6S2. Mole weight: 377.44.
Sparsentan
Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with K i s of 0.8 and 9.3 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RE-021; DARA-a. CAS No. 254740-64-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17621.
Sparsentan impurity 10
Sparsentan impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1026355-73-6. Molecular formula: C34H44N4O6S. Mole weight: 636.81. Catalog: APB1026355736.
Sparsentan impurity 11
Sparsentan impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1255948-71-0. Molecular formula: C10H13BrO2. Mole weight: 245.12. Catalog: APB1255948710.
Sparsentan impurity 12
Sparsentan impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1255948-72-1. Molecular formula: C11H15BrO4S. Mole weight: 323.2. Catalog: APB1255948721.
Sparsentan impurity 13
Sparsentan impurity 13. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1255948-74-3. Molecular formula: C23H31BrN2O6. Mole weight: 511.41. Catalog: APB1255948743.
Sparsentan impurity 2
Sparsentan impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1399412-15-7. Molecular formula: C32H38N4O6S. Mole weight: 606.74. Catalog: APB1399412157.
Sparsentan impurity 7
Sparsentan impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1247868-68-3. Molecular formula: C25H30N2O7S. Mole weight: 502.58. Catalog: APB1247868683.
Sparsentan impurity 9
Sparsentan impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1026273-26-6. Molecular formula: C23H27BrN2O5S. Mole weight: 523.44. Catalog: APB1026273266.
Sparsentan (RE-021)
Sparsentan, also known as RE-021, BMS346567, is a dual antagonist of both angiotensin II and endothelin A receptor antagonist. Synonyms: 2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide; RE-021; RE021; RE 021; PS-433540; PS433540; PS 433540; DARA-a; Sparsentan. Grades: >98%. CAS No. 254740-64-2. Molecular formula: C32H40N4O5S. Mole weight: 592.75.
Sparsomycin
It is an anti-tumor drug produced by the strain of Str. sparsogenes var. sparsogenes NRRL 2940, Str. cuspidosporus B-79. It has the effect of anti-bacterial and a few fungi. 0.05 μg/mL of Sparsomycin can inhibit the synthesis of 50% KB cell protein, it has the inhibitory effect on 11 kinds of experimental tumor, such as sarcoma-180 solid type, sarcoma-180 ascites type and Eschericz ascites carcinoma. Uses: Antibiotics, antineoplastic. Synonyms: Upjohn Antibiotic 155b1t; 2-Propenamide, N-(1-(hydroxymethyl)-2-(((methylthio)methyl)sulfinyl)ethyl)-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (S-(E))-; 2-Propenamide, N-[1-(hydroxymethyl)-2-[[(methylthio)methyl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, [R-[R*,S*-(E)]]-; (+)-Sparsomycin; NSC 059729. Grades: >95%. CAS No. 1404-64-4. Molecular formula: C13H19N3O5S. Mole weight: 361.47.
Spartalizumab is a humanized anti-PD-1 IgG4 antibody under the development of melanoma treatment. Synonyms: PDR001. CAS No. 1935694-88-4.
Spartalizumab
Spartalizumab (PDR001) is a humanized immunoglobulin 4 monoclonal antibody that binds PD-1 with subnanomolar activity and blocks interaction with PD-L1 and PD-L2. Spartalizumab can be used for the research of anaplastic thyroid carcinoma (ATC) [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: PDR001. CAS No. 1935694-88-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9972.
Sparteine
Sparteine is a natural alkaloid extracted from scotch broom. It inhibits mAChR M2 and M4, and displays anticonvulsant effects. It also inhibits nAChR in the neurons. Synonyms: 7,14-Methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine, dodecahydro-, (7S,7aR,14S,14aS)-; (7S,7aR,14S,14aS)-Dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine; 7,14-Methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine, dodecahydro-, [7S-(7α, 7aα, 14α, 14aβ)]-; (-)-Sparteine; 6β,7α,9α,11α-Pachycarpine; L-(-)-Sparteine; L-Sparteine; l-Sparteine; Lupinidin; Lupinidine; Spartein. Grades: ≥98%. CAS No. 90-39-1. Molecular formula: C15H26N2. Mole weight: 234.38.
Sparteine Sulfate
A class 1a antiarrhythmic agent; a sodium channel blocker. Group: Biochemicals. Alternative Names: (7S,7aR,14S,14aS)-Dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine Sulfate; Sparteine Sulfate; NSC 143087; NSC 26253; NSC 402663; Spartepur; Spal; Spareng; Sparm; Sparteal; Spartocin; Spartin; Spatym; Tocosimplex; [7S-(7α, 7aα, 14α, 14a β)]-Dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine Sulfate. Grades: Highly Purified. CAS No. 299-39-8. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Spathulenol
Spathulenol is isolated from Aristolochia yunnanensis , and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC 50 of 85.60 μg/mL in the DPPH system [1]. Uses: Scientific research. Group: Natural products. CAS No. 6750-60-3. Pack Sizes: 1 mg. Product ID: HY-N1205.
Spautin 1
Spautin 1. Group: Biochemicals. Grades: Purified. CAS No. 1262888-28-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Spautin-1
Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ?0.6-0.7 μM. Synonyms: Spautin-1; Spautin1; Spautin 1. Grades: 99%. CAS No. 1262888-28-7. Molecular formula: C15H11F2N3. Mole weight: 271.26.
Spautin-1 is a specific and potent autophagy inhibitor which inhibits ubiquitin-specific peptidases, USP10 and USP13 with IC50s of 0.6-0.7 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 1262888-28-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12990.
Spautin-1 (6-fluoro-N- [4-fluorobenzyl] quinazolin-4-amine, Specific and Potent AUtophagy Inhibitor 1, C43, Autophagy Inhibitor II)
A quinazolin compound that acts as a specific and potent inhibitor of autophagy and promotes Vps34 PI 3-kinase complex degradation by blocking the activity of USP 10 (IC50 = 580nM) and USP 13 (IC50 = 690nM) deubiquitinating enzymes. However, it does not affect the lipid kinase activity of Vps34. Also shown to reduce the level of cytoplasmic and nuclear p53. Sensitizes breast cancer cell lines (BCAP37, MCF-7, and BT549) to apoptosis under conditions of nutritional deprivation. Also shown to inhibit etoposide-induced cell death in Bax/Bak double knockout (DKO) cells. Normal cell lines (e.g., MDCK cells) do not undergo autophagy in the presence of Spautin-1. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Cell-permeable. A specific and potent autophagy inhibitor in mammalian cells. It promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin specific peptidases, USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes. Spautin-1 blocks the prosurvival autophagy pathway in cancer cells. Group: Biochemicals. Alternative Names: 6-Fluoro-N- (4-fluorobenzyl) quinozaline-4-amine. Grades: Highly Purified. CAS No. 1262888-28-7. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
Worldwide
S-(P-AZIDOPHENACYL)GLUTATHIONE
Cas No. 73322-71-1.
SPB
SPB is a agent-linker conjugate for ADC with potent anti-inflammatory activity by using Xanthotoxol, linked via the ADC linker. Uses: Scientific research. Group: Signaling pathways. CAS No. 858128-57-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104025.
SP-B
SP-B is an antimicrobial peptide (AMP) isolated from Sus scrofa. It has activity against fungi. Synonyms: Ala-Pro-Pro-Gly-Ala-Arg-Pro-Pro-Pro-Gly-Pro-Pro-Pro-Pro-Gly-Pro-Pro-Pro-Pro-Gly-Pro. Grades: >97%. Molecular formula: C90H134N24O22. Mole weight: 1904.21.
SPBc2 prophage-derived bacteriocin sublancin-168
SPBc2 prophage-derived bacteriocin sublancin-168 is an antimicrobial peptide (AMP) isolated from Bacillus subtilis. It has activity against gram-positive bacteria and gram-negative bacteria. Synonyms: Ile-Gly-Cys-Gly-Gly-Gly-Ala-Val-Ala-Cys-Gln-Asn-Tyr-Arg-Gln-Phe-Cys-Arg. Grades: >95%. Molecular formula: C78H123N27O23S3. Mole weight: 1903.19.
SPC5001 sodium is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 sodium can be used for the research of hypercholesterolemia. SPC5001 sequence: 5?-TGmCTACAAAACmCmCA-3?[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-148687A.
SPC 839
SPC 839 (compound 10) is an orally active inhibitor of AP-1 and NF-kB mediated transcriptional activation with IC50 of 0.008 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 219773-55-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10072.
Sp-cAMPS-AM
Sp-cAMPS-AM is a precursor of Sp-cAMPS, the PDE-resistant protein kinase A stimulator. Sp-cAMPS is released after metabolism of Sp-cAMPS-AM by esterases. Synonyms: Adenosine- 3', 5'- monophosphorothioate acetoxymethyl ester, Sp- isomer. Grades: ≥ 97% by HPLC for mixture of the axial and equatorial isomer. CAS No. 152218-24-1. Molecular formula: C13H16N5O7PS. Mole weight: 417.3.
Sp-cAMPS, sodium salt
Sp-cAMPS is an activator of protein kinase A (cAMP agonist). It exhibits high resistance against cyclic nucleotide phosphodiesterases and membrane permeability in organisms. Uses: Protein kinase inhibitors. Synonyms: Adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 71774-13-5. Molecular formula: C10H11N5O5PS · Na. Mole weight: 367.3.