A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Heterocyclic Organic Compound. Alternative Names: BLACK 305;2-(Phenylamino)-6-(dipentylamino)-3-methylspiro[9H-xanthene-9,3'-phthalide];2'-Anilino-3'-methyl-6'-(dipentylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one;6'-(Dipentylamino)-3'-methyl-2'-anilinospiro[isobenzofuran-1(3H),9'-[9H]xanthene]. CAS No. 129473-78-5. Molecular formula: C37H40N2O3. Catalog: ACM129473785.
Spirolaxine
Spirolaxine is a long-chain phthalide antibiotic produced by Sporotrichum laxum. It exhibits anti-Helicobacter pylori property. Synonyms: (+)-spirolaxine; Spirolaxin; (3R)-5-Hydroxy-7-methoxy-3-[5-[(2R,5R,7R)-2-methyl-1,6-dioxaspiro[4.5]dec-7-yl]pentyl]-1(3H)-isobenzofuranone. Grades: ≥95%. CAS No. 126382-01-2. Molecular formula: C23H32O6. Mole weight: 404.50.
This product is an enabling product used as a Hole Transport Material for high-performance solar cells and thus has been enhanced for energy efficiency. Uses: High-mobility material used for white oleds to increase hole injection and transport. it is the best solid-state hole transporting material, to date, used to replace the liquid electrolyte for dssc solar cells, due to an excellent pore-filling property in nanoporous tio2 film with pore size of around 30-50 nm; attributed to its small molecular size. Group: Silsesquioxane (poss). Alternative Names: N2,N2,N2',N2',N7,N7,N7',N7'-octakis(4-methoxyphenyl)-9,9'-spirobi[9H-fluorene]-2,2',7,7'-tetramine,Spiro-OMeTAD. CAS No. 207739-72-8. Product ID: 2,2,7,7-tetrakis(N,N-di-p-methoxyphenyl-amine)-9,9-spirobifluorene. Molecular formula: 1225.43. Mole weight: C81H68N4O8. COC (C=C1)=CC=C1N (C2=CC=C (C=C2)OC)C (C=C3)=CC4=C3C (C=CC (N (C5=CC=C (C=C5)OC)C6=CC=C (C=C6)OC)=C7)=C7C84C9=C (C=CC (N (C%10=CC=C (C=C%10)OC)C%11=CC=C (C=C%11)OC)=C9)C%12=C8C=C (N (C%13=CC=C (C=C%13)OC)C%14=CC=C (C=C%14)OC)C=C%12. 95%+.
Spiro-MeOTAD
This product is an enabling product used as a Hole Transport Material for high-performance solar cells and thus has been enhanced for energy efficiency. Uses: High-mobility material used for white oleds to increase hole injection and transport. it is the best solid-state hole transporting material, to date, used to replace the liquid electrolyte for dssc solar cells, due to an excellent pore-filling property in nanoporous tio2 film with pore size of around 30-50 nm; attributed to its small molecular size. Group: Dye-sensitized solar cell (dssc). Alternative Names: N2,N2,N2',N2',N7,N7,N7',N7'-octakis(4-methoxyphenyl)-9,9'-spirobi[9H-fluorene]-2,2',7,7'-tetramine,Spiro-OMeTAD. CAS No. 207739-72-8. Molecular formula: C81H68N4O8. Mole weight: 1225.43. Purity: 95%+. IUPACName: 2,2,7,7-tetrakis(N,N-di-p-methoxyphenyl-amine)-9,9-spirobifluorene. Canonical SMILES: COC (C=C1)=CC=C1N (C2=CC=C (C=C2)OC)C (C=C3)=CC4=C3C (C=CC (N (C5=CC=C (C=C5)OC)C6=CC=C (C=C6)OC)=C7)=C7C84C9=C (C=CC (N (C%10=CC=C (C=C%10)OC)C%11=CC=C (C=C%11)OC)=C9)C%12=C8C=C (N (C%13=CC=C (C=C%13)OC)C%14=CC=C (C=C%14)OC)C=C%12. Density: 1.06 g/ml. Catalog: ACM207739728-5.
Spiro-MeOTAD
This product is an enabling product used as a Hole Transport Material for high-performance solar cells and thus has been enhanced for energy efficiency. Uses: High-mobility material used for white oleds to increase hole injection and transport. it is the best solid-state hole transporting material, to date, used to replace the liquid electrolyte for dssc solar cells, due to an excellent pore-filling property in nanoporous tio2 film with pore size of around 30-50 nm; attributed to its small molecular size. Group: Organic light-emitting diode (oled) materials. Alternative Names: N2,N2,N2',N2',N7,N7,N7',N7'-octakis(4-methoxyphenyl)-9,9'-spirobi[9H-fluorene]-2,2',7,7'-tetramine,Spiro-OMeTAD. CAS No. 207739-72-8. Pack Sizes: 1, 5 g in glass bottle. Product ID: 2,2,7,7-tetrakis(N,N-di-p-methoxyphenyl-amine)-9,9-spirobifluorene. Molecular formula: 1225.43. Mole weight: C81H68N4O8. COC (C=C1)=CC=C1N (C2=CC=C (C=C2)OC)C (C=C3)=CC4=C3C (C=CC (N (C5=CC=C (C=C5)OC)C6=CC=C (C=C6)OC)=C7)=C7C84C9=C (C=CC (N (C%10=CC=C (C=C%10)OC)C%11=CC=C (C=C%11)OC)=C9)C%12=C8C=C (N (C%13=CC=C (C=C%13)OC)C%14=CC=C (C=C%14)OC)C=C%12. InChI=1S/C81H68N4O8/c1-86-65-29-9-53 (10-30-65) 82 (54-11-31-66 (87-2) 32-12-54) 61-25-45-73-74-46-26-62 (83 (55-13-33-67 (88-3) 34-14-55) 56-15-35-68 (89-4) 36-16-56) 50-78 (74) 81 (77 (73) 49-61) 79-51-63 (84 (57-17-37-69 (90-5) 38-18-57) 58-19-39-70 (91-6) 40-20-58) 27-47-75 (79) 76-48-28-64 (52-80 (76) 81) 85 (59-21-41-71
Spiromesifen
Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen reduces lipid biosynthesis via inhibition of acetyl-CoA carboxylase , and has no cross-resistance to any resistant mite or whitefly populations [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BSN 2060. CAS No. 283594-90-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-114591.
Spiromesifen Metabolite M01
It is the metabolite of Spiromesifen, which is a spirocyclic tetronic acid, environmentally friendly and novel structural pesticide. Synonyms: 1-Oxaspiro[4.4]non-3-en-2-one, 4-hydroxy-3-(2,4,6-trimethylphenyl)-; 3-Mesityl-2-oxo-1-oxaspiro(4.4)non-3-en-4-ol; Spiromesifen-alcohol; 4-Hydroxy-3-mesityl-1-oxaspiro(4.4)non-3-en-2-one. Grades: ≥90%. CAS No. 148476-30-6. Molecular formula: C17H20O3. Mole weight: 272.34.
Spironolactone
Spironolactone is a synthetic, 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conns syndrome. Group: Biochemicals. Alternative Names: 7α,7α)-7-(Acetylthyo)-17-hydroxy-3-oxopregn-4-one-21-carboxylic Acid γ-Lactone; 7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17-carbolactone; SC-9420; Adactone. Grades: Highly Purified. CAS No. 52-01-7. Pack Sizes: 50g, 100g. Molecular Formula: C??H??O?S, Molecular Weight: 416.57. US Biological Life Sciences.
Worldwide
Spironolactone
5g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C24H32O4S. CAS No. 52-01-7. Prepack ID 49631028-5g. Molecular Weight 416.57. See USA prepack pricing.
Spironolactone
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor ( IC 50 =24 nM) and androgen receptor ( IC 50 =77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang?)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type ? diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca 2+ channels to exert antihypertensive effects [1] [2] [3] [4] [5] [6] [7] [8] [9] [10]. Uses: Scientific research. Group: Natural products. Alternative Names: SC9420. CAS No. 52-01-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g; 5 g. Product ID: HY-B0561.
Spironolactone acid
An impurity of Spironolactone Spironolactone is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. Grades: > 95%. Molecular formula: C24H34O5S. Mole weight: 434.60.
t is a synthetic 17-lac. Group: Biochemicals. Alternative Names: (7a,7a)-7-(Acetylthyo-d3)-17-hydroxy-3-oxopregn-4-one-21-carboxylic Acid g-Lactone; 7a-Acetylthio-d3-3-oxo-17a-pregn-4-ene-21,17-carbolactone; SC-9420-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Spironolactone EP Impurity 10
Spironolactone EP Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 38753-76-3. Molecular Formula: C22H30O3S. Mole Weight: 374.54. Catalog: APB38753763.
Spironolactone EP Impurity 11
Spironolactone EP Impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 132152-57-9. Molecular Formula: C18H22O3. Mole Weight: 286.37. Catalog: APB132152579.
Spironolactone EP Impurity 12
Spironolactone EP Impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2202-1-9. Molecular Formula: C27H42O4. Mole Weight: 430.62. Catalog: APB2202019.
Spironolactone EP Impurity 13
Spironolactone EP Impurity 13. Uses: For analytical and research use. Group: Impurity standards. CAS No. 41059-95-4. Molecular Formula: C22H32O6. Mole Weight: 392.49. Catalog: APB41059954.
Spironolactone EP Impurity 14
Spironolactone EP Impurity 14. Uses: For analytical and research use. Group: Impurity standards. CAS No. 18456-03-6. Molecular Formula: C21H28O6S. Mole Weight: 408.51. Catalog: APB18456036.
Spironolactone EP Impurity 15
Spironolactone EP Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 35945-70-1. Molecular Formula: C17H24O4. Mole Weight: 292.38. Catalog: APB35945701.
Spironolactone EP Impurity 16
Spironolactone EP Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 18455-98-6. Molecular Formula: C22H30O6. Mole Weight: 390.48. Catalog: APB18455986.
Spironolactone EP Impurity 18
Spironolactone EP Impurity 18. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C22H30O4. Mole Weight: 358.48. Catalog: APB10839.
Spironolactone EP Impurity A
Spironolactone EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 132458-33-4. Molecular Formula: C24H30O4S. Mole Weight: 414.56. Catalog: APB132458334.
Spironolactone EP Impurity A (Delta-20-Spironolactone)
an impurity of Spironolactone. Synonyms: (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxo-pregna-4,20-diene-21-carboxylic Acid γ-Lactone; spiro[17H-cyclopenta[a]phenanthrene-17,2'(5'H)-furan] Pregna-4,20-diene-21-carboxylic Acid Deriv. Grades: > 95%. CAS No. 132458-33-4. Molecular formula: C24H30O4S. Mole weight: 414.57.
Spironolactone EP Impurity B
Spironolactone EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C24H31BrO4S. Mole Weight: 495.47. Catalog: APB10836.
Spironolactone EP Impurity C
an intermediate in the synthesis of Canrenone. Synonyms: 6,7-Dihydrocanrenone; 17-Hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic Acid γ-Lactone; 17β-Hydroxy-3-oxopregn-4-en-21-carboxylic Acid γ-Lactone; 3-(3-Oxo-17β-hydroxy-4-androsten-17-yl)propionic Acid γ-Lactone; 3-(3-Oxo-17β-hydroxyandrost-4-en-17α-yl)propiol. Grades: > 95%. CAS No. 976-70-5. Molecular formula: C22H30O3. Mole weight: 342.48.
Spironolactone EP Impurity C
Spironolactone EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. CAS No. 976-70-5. Molecular Formula: C22H30O3. Mole Weight: 342.48. Catalog: APB976705.
Spironolactone EP Impurity D
Spironolactone EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C24H32O4S2. Mole Weight: 448.64. Catalog: APB10837.
Spironolactone EP Impurity E
Spironolactone EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. CAS No. 33784-05-3. Molecular Formula: C24H32O4S. Mole Weight: 416.58. Catalog: APB33784053.
Spironolactone EP Impurity G
Spironolactone EP Impurity G. Uses: For analytical and research use. Group: Impurity standards. CAS No. 880106-10-5. Molecular Formula: C24H32O5S. Mole Weight: 432.58. Catalog: APB880106105.
Spironolactone EP Impurity H
Spironolactone EP Impurity H. Uses: For analytical and research use. Group: Impurity standards. CAS No. 53866-24-3. Molecular Formula: C20H26O2. Mole Weight: 298.43. Catalog: APB53866243.
Spironolactone EP Impurity I
Spironolactone EP Impurity I. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C24H36O4S. Mole Weight: 420.61. Catalog: APB10838.
Spironolactone EP Impurity I
An impurity of Spironolactone Spironolactone is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. Synonyms: 7α-Acetylthio-17α-ethoxymethy Testosterone. Grades: > 95%. Molecular formula: C24H36O4S. Mole weight: 420.61.
Spironolactone Impurity B
An impurity of Spironolactone Spironolactone is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. Synonyms: 4-Bromo-spironolactone. Grades: > 95%. Molecular formula: C24H31BrO4S. Mole weight: 495.48.
Spironolactone Impurity G
An impurity of Spironolactone Spironolactone is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. Synonyms: Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-6,17-dihydroxy-3-oxo-,g-lactone, (6b,7a,17a)-. Grades: > 95%. CAS No. 880106-10-5. Molecular formula: C24H32O5S. Mole weight: 432.58.
Spironolactone Impurity H
Cas No. 55706-91-7.
Spironolactone Related Compound
an impurity of Spironolactone. Synonyms: S-[17-Alfa-(Ethoxymethyl)-17-hydroxy-3-oxoandrost-4-en-7-alfa-yl] Ethanethioate; 7β-Acetylthio-17α-ethoxymethy Testosterone; Spironolactone EP Impurity I. Grades: > 95%. Molecular formula: C24H36O4S. Mole weight: 420.62.
Spironolactone (Standard)
Spironolactone (Standard) is the analytical standard of Spironolactone. This product is intended for research and analytical applications. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC 50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC 50 of 77 nM. Spironolactone promotes autophagy in podocytes [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SC9420 (Standard). CAS No. 52-01-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0561R.
Spiro-Oxanthromicin A
Spiro-Oxanthromicin A is a polyketide first isolated from a soil-derived Streptomyces sp. Spiro-Oxanthromicin A inhibits mislocalisation of the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells. It inhibits Bacillus cereus but has no activity against HSV-1, Mycobacterium tuberculosis H37Ra and phytopathogenic fungi. Synonyms: Oxanthromicin A, spiro; (±)-spiro-oxanthromicin A; 2',7'-dihydro-2,5,6',10'-tetrahydroxy-4,5',6,8'-tetramethyl-7',10-dioxo-spiro[anthracene-9(10H),3'-[3H]benz[de]anthracene]-3,9'-dicarboxylic acid; 2,5,6',10'-tetrahydroxy-4,5',6,8'-tetramethyl-7',10-dioxo-2',7'-dihydro-10H-spiro[anthracene-9,3'-benzo[de]anthracene]-3,9'-dicarboxylic acid. Grades: ≥95% by HPLC. CAS No. 1616622-10-6. Molecular formula: C36H26O10. Mole weight: 618.58.
Spirotetramat (BY-108330) is a pesticide, that can be used to control aphids on crops, without significant phytotoxicity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BY-108330. CAS No. 203313-25-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-120253.
It is a mammalian cell cycle inhibitor produced by the strain of Aspergillus fumigatus. 12.5 μg/mL of Spirotryprostatin B can inhibit the G2/M phase of the cell cycle in tsFT210 cells. Synonyms: (3S,3'S,5'aS)-6-Methoxy-3'-(2-methylprop-1-enyl)spiro[1H-indole-3,2'-5a,6,7,8-tetrahydro-3H-dipyrrolo[1,2-c:1',3'-f]pyrazine]-2,5',10'-trione; Spiro[5H,10H-dipyrrolo[1,2-a:1',2'-d]pyrazine-2(3H), 3'-[3H]indole]-2',5,10(1'H)-trione, 5a,6,7,8-tetrahydro-3-(2-methyl-1-propen-1-yl)-, (2S,3S,5aS)-. CAS No. 182234-26-0. Molecular formula: C21H21N3O3. Mole weight: 363.41.
Spiroxamine
Spiroxamine is a fungicide that can be used to kill grapes with less residue [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 118134-30-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-121884.
Spiroxamine
Spiroxamine. Group: Biochemicals. Alternative Names: 8-(1,1-Dimethylethyl)-N-ethyl-N-propyl-1,4-dioxaspiro[4.5]decane-2-methanamine; Impulse; Impulse. Grades: Highly Purified. CAS No. 118134-30-8. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C18H35NO2. US Biological Life Sciences.
Worldwide
Spiroxatrine
Spiroxatrine is a 5-HT1A antagonist and a potent α2C adrenergic receptor antagonist. Spiroxatrine exhibits great anxiolytic effects in combination with buspirone. Synonyms: 8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one. CAS No. 1054-88-2. Molecular formula: C22H25N3O3. Mole weight: 379.46.
Spiroxatrine
Spiroxatrine. Group: Biochemicals. Grades: Purified. CAS No. 1054-88-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Spiroxatrine
Heterocyclic Organic Compound. Alternative Names: Spiroxatrine; R 5188; Spiroxatrinum; spiroxatriene; L-803,087 trifluoroacetate; Espiroxatrina. CAS No. 1054-88-2. Molecular formula: C22H25N3O3. Mole weight: 379.45. Purity: 0.96. IUPACName: 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-4-phenyl-2,4,8-triazaspiro[4.5]decan-1-one. Density: 1.32g/cm³. Catalog: ACM1054882.
Spirulina Extract
Extract obtained from Spirulina Maxima (Spirulina) plants. Contains 20% extract dissolved in water and glycerin. Has good moisturizing, humectant and emollient properties. Uses: Creams and lotions and hair care products. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 536993-92-7 / 122-99-6. Appearance: Light yellow to medium green liquid, characteristic odor. Catalog: CI-SC-0774.
Spirulina Powder
Spirulina powder is made from the spirulina, a microscopic blue-green algae in the shape of a perfect spiral coil living both in sea and fresh water. Spirulina powder supplied by yesherb contains high amount of protein, between 55% -77% by dry weight. Spirulina powder is a complete protein, containing all essential amino acids, and rich in essential fatty acids, variety of vitamins and minerals. Group: Others. Spirulina Powder; Spirulina. Cat No: EXTC-121.
Spirulina Powder
Spirulina Powder. CAS No. 724424-92-4.
Spirulina Powder
100g Pack Size. Group: Biochemicals, Diagnostic Raw Materials, Flavours and Fragrance Materials. Formula: N/A. CAS No. 724424-92-4. Prepack ID 89991888-100g. See USA prepack pricing.
Spisulosine
Spisulosine, also known as ES-285, is novel compound derived from the marine mollusk Spisula polynoma with evidence of preclinical antitumor activity. Phase I clinical trial results: Dose level VIII (200 mg/m(2)) was considered the MTD, and dose level IX (160 mg/m(2)) was defined as the RD. Limited antitumor activity was observed. Synonyms: 1-deoxysphinganine (m18:0); ES-285; ES 285; ES285; 1-deoxy SA; (2S,3R)-2-amino-3-hydroxy-octadecane; (+)-Spisulosine; 3-Octadecanol, 2-amino-, (R-(R*,S*))-; (2S,3R)-2-amino-3-octadecanol; 2S-amino-3R-octadecanol. Grades: >99%. CAS No. 196497-48-0. Molecular formula: C18H39NO. Mole weight: 285.51.
SPK-601
SPK-601 is a potent phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor,a useful antimicrobial agent. Synonyms: LMV-601; LMV601; LM -601; SPK601; SPK-601; SPK 601. Grades: >98%. CAS No. 1096687-52-3. Molecular formula: C11H15KOS2. Mole weight: 266.46.
SPL 334
SPL 334 is an S-nitrosoglutathione reductase inhibitor that prevents weight loss, and alleviates lung inflammation and fibrosis in a bleomycin injury model of interstitial lung disease in mice. Synonyms: SPL-334; SPL334; SPL 334; 4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 688347-51-5. Molecular formula: C22H15N3O3S2. Mole weight: 433.5.
sPLA2-IIA Inhibitor II, KH064 ( (S) -5- (4- (benzyloxy) phenyl) -4- (7-phenylheptanamido) pentanoic Acid, Phospholipase A2 Group IIA Inhibitor II, PLA2g2a Inhibitor II)
A reversible, potent, and selective sPLA2-IIA/PLA2g2a (phospholipase A2 group IIA) inhibitor (IC50 = 29nM) that displays much reduced potency against sPLA2-V/PLA2g5 (PLA2 group V; IC50 = 2uM) and is reported not to affect the activity of cytosolic cPLA2, Ca2+-independent iPLA2, 30 human GPCRs, and 25 other enzymes. In addition to being useful in studying PLA2g2a-mediated cellular responses in cultures in vitro (100% inhibition of LPS-induced PGE2 production in HMC-1 cells; 15 min 10uM pretreatment), KH064 is orally available in rats and efficacious in various rat disease models in vivo (5mg/kg p.o.), including adjuvant-induced arthritis, spontaneous hypertension, high fat diet-induced metabolic disorders. Comparing to the substrate-competitive inhibitor c(2NapA)LS(2NapA)R, KH064 also effectively chelates sPLA2-IIA active site Ca2+ in addition to targeting the enzyme's N-terminal lipid substrate binding site. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
sPLA2 Inhibitor
sPLA2 Inhibitor is an orally active inhibitor of secreted phospholipases A2 IIA (sPLA2-IIA). It exhibits anti-inflammatory effects, and attenuates NF-κB signaling in lung cancer cells and protects against diet-induced metabolic syndrome in rats. Synonyms: KH064; Secretory Phospholipase A2 Inhibitor; (S)-5-(4-Benzyloxy-phenyl)-4-(7-phenyl-heptanoylamino)-pentanoic acid; (4S)-4-(7-phenylheptanoylamino)-5-(4-phenylmethoxyphenyl)pentanoic acid. Grades: ≥95%. CAS No. 393569-31-8. Molecular formula: C31H37NO4. Mole weight: 487.6.
SPL-B
SPL-B is an orally active inhibitor of transforming acidic coiled-coil protein (TACC3) exhibiting an inhibitory effect against the nucleation of centrosome microtubules in ovarian cancer cells, without affecting spindle assembly in normal cells. SPL significantly inhibits mitosis in cancer cells and tumor growth. Uses: Antitumor agent. Synonyms: 8-[[ethyl(pyridin-4-ylmethyl)amino]methyl]-7-hydroxy-4-(2-oxochromen-3-yl)chromen-2-one. Grades: 98%. CAS No. 1465248-60-5. Molecular formula: C27H22N2O5. Mole weight: 454.47.
Spleen, Bovine
Spleen, Bovine. Group: Biologicals. Grades: Tissue. Pack Sizes: 5Ea. US Biological Life Sciences.
Worldwide
spleen exonuclease
Preference for single-stranded substrate. Group: Enzymes. Synonyms: 3'-exonuclease; spleen phosphodiesterase; 3'-nucleotide phosphodiesterase; phosphodiesterase II. Enzyme Commission Number: EC 3.1.16.1. CAS No. 9068-54-6. PDE. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3543; spleen exonuclease; EC 3.1.16.1; 9068-54-6; 3'-exonuclease; spleen phosphodiesterase; 3'-nucleotide phosphodiesterase; phosphodiesterase II. Cat No: EXWM-3543.
Spleen Extract, Bovine
Activities include Ro (SS-A), La (SS-B), Sm, and RNP. Group: Biologicals. Grades: Lysate. Pack Sizes: 1ml. US Biological Life Sciences.
Worldwide
Spleen, Rabbit
Spleen, Rabbit. Group: Biologicals. Grades: Tissue. Pack Sizes: 50Ea. US Biological Life Sciences.
Worldwide
Splenopentin diacetate
Heterocyclic Organic Compound. Alternative Names: ARG-LYS-GLU-VAL-TYR ACETATE SALT;SPLENIN FRAGMENT 32-36 ACETATE SALT;SPLENOPENTIN ACETATE SALT;SP-5 ACETATE SALT;ARG-LYS-GLU-VAL-TYR ACETATE;SP-5, Splenin Fragment 32-36, Splenopentin;L-Arginyl-L-lysyl-L-alpha-glutamyl-L-valyl-L-tyrosine diacetate;Sp. CAS No. 105184-37-0. Molecular formula: C31H51N9O9.2(C2H4O2). Mole weight: 813.9. Purity: >98%. Catalog: ACM105184370.