A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Crystalline, purity 99+%. Synonym: 3,4-Dihydroxy-3-cyclobutene-1,2-dione. CAS No. 2892-51-5. Pack Sizes: Typically in stock: 10g, 50g. Mole weight: 114.06. MP/BP: M.P. >300. Order No: FR-0532.
Frinton Laboratories
Squaric Acid-[d2]
Squaric Acid-[d2] is the labelled analogue of Squaric Acid. Synonyms: Squaric acid-d2; 3,4-Dihydroxy-3-cyclobutene-1,2-dione-d2. Grade: 95% by CP; 98% atom D. CAS No. 31150-56-8. Molecular formula: C4D2O4. Mole weight: 116.07.
Squarunkin A
Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A-myristoylated Src N-terminal peptide interaction (IC50=10 nM). Squarunkin A interferes with the activation of Src kinase in cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2101958-02-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-127002.
Squaw Vine Powder
Squaw Vine Powder.
CA, FL & NJ
SR-0813
SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 and EC50 values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC50 and EC50 values of 311 nM and 76 nM (CETSA) for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity (Kd=3.5 ?M) than ENL YEATS (Kd=30 nM). SR-0813 can be used for the research of acute leukemia[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2597186-19-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145409.
SR1001 is a selective ROR α and ROR γt inverse agonist with K i s 172 and 111 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1335106-03-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13421.
SR1078 is a selective agonist of retinoic acid receptor-related orphan receptor ?/? (ROR?/ROR?). SR1078 directly binds to the ligand binding domain of ROR? and ROR? and increases the transcriptional activity of these receptors, leading to stimulation of ROR?/? target gene transcription[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1246525-60-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14422.
SR 11023
SR 11023 is an orally active antagonist of PPAR γ, with the IC 50 value of 109 nM that plays an important role in diabetic research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1820602-13-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160162.
SR11237
SR11237 (BMS-649) is a potent retinoid X receptor (RXR)-selective agonist that is devoid of any RAR activity. SR11237 can cause RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-649. CAS No. 146670-40-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107413.
SR 11237. Group: Biochemicals. Grades: Purified. CAS No. 146670-40-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR 11237
SR 11237 is a pan retinoid X receptor (RXR) agonist. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SR 11237; SR11237; SR-11237; BMS 649; BMS-649; BMS649; BMS 188649; BMS-188649; BMS188649. Product Category: Agonists. Appearance: Solid powder. CAS No. 146670-40-8. Molecular formula: C24H28O4. Mole weight: 380.48. Purity: >98%. IUPACName: 4-(2-(5,6,7,8-Tetrahydro-5,5,8,8,-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl)benzoic acid. Canonical SMILES: O=C(O)C1=CC=C(C2(C3=CC=C4C(C)(C)CCC(C)(C)C4=C3)OCCO2)C=C1. Product ID: ACM146670408-1. Alfa Chemistry ISO 9001:2015 Certified.
SR 11302
SR 11302. Group: Biochemicals. Grades: Purified. CAS No. 160162-42-5. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
SR 11302
SR 11302. CAS No: 160162-42-5
Sarchem Laboratories New Jersey NJ
SR 11302
SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 160162-42-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15870.
SR12343
SR12343, an IKK/NF-?B inhibitor, is a NF-?B essential modulator (NEMO)-binding domain (NBD) mimetic. SR12343 inhibits TNF-?- and LPS-induced NF-?B activation by blocking the interaction between IKK? and NEMO, with an IC50 of 37.02 ?M for TNF-?-mediated NF-?B activation. SR12343 suppresses LPS-induced acute pulmonary inflammation in mice. SR12343 can be used for research of inflammatory and degenerative diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2055101-86-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-123936.
SR12813
SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase , with an IC 50 value of 0.85 μM [1] [2]. SR12813 is also an efficient agonist of human pregnane X receptor ( hPXR ). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR) [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW 485801. CAS No. 126411-39-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-100793.
SR 12813
SR 12813. Group: Biochemicals. Grades: Purified. CAS No. 126411-39-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR 140333
SR 140333. Group: Biochemicals. Grades: Purified. CAS No. 153050-21-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR 141716A
SR 141716A. Group: Biochemicals. Grades: Purified. CAS No. 158681-13-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR 142948
SR 142948 is an orally active and selective non-peptide neurotensin receptor ( NT ) antagonist with IC 50 s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. SR 142948 antagonizes NT-induced inositol monophosphate formation in HT-29 cells with an IC50 of 3.9 nM. SR 142948 blocks hypothermia, analgesia and steering behavior induced by NT in vivo. SR 142948 shows blood-brain permeability and can be used in study of psychiatric disorders [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 184162-64-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107664.
SR 142948
SR 142948. Group: Biochemicals. Grades: Purified. CAS No. 184162-64-9. Pack Sizes: 1mg, 10mg. US Biological Life Sciences.
Worldwide
SR 142948A
SR 142948A is a non-peptide neuropeptide neuropeptin ( NT ) receptor antagonist. SR 142948A is able to bind to neuropeptin receptors, especially with high affinity for NT1 and NT2 receptors. SR 142948A is mainly used to study the role of neuropeptide in the neurotransmitter system, especially the dopamine system [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 184162-21-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-124767.
SR144528 is a potent and selective CB2 receptor antagonist with a Ki of 0.6 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 192703-06-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13439.
SR 144528
SR 144528. Group: Biochemicals. Alternative Names: (1S-endo)-5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-(1, 3, 3-trimethylbicyclo[2. 2. 1]hept-2-yl)-1H-Pyrazole-3-carboxamide. Grades: Highly Purified. CAS No. 192703-06-3. Pack Sizes: 5mg. Molecular Formula: C29H34ClN3O, Molecular Weight: 476.05. US Biological Life Sciences.
Worldwide
SR15006
SR15006 is a inhibitor of Krüppel-like factor 5 (KLF5). SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo. SR18662 significantly reduces growth and proliferation of colorectal cancer cells as compared with treatment with vehicle control, SR18662 showed improved efficacy in reducing the viability of multiple colorectal cancer cell lines. SR18662 treatment also reduces the expression of cyclins and components of the MAPK and WNT signaling pathways. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SR15006; SR-15006; SR 15006. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2505001-54-5. Molecular formula: C16H20ClN3O4S. Mole weight: 385.86. Purity: >98%. IUPACName: (E)-3-(3-chlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide. Canonical SMILES: O=C(NCC(N1CCN(S(=O)(C)=O)CC1)=O)/C=C/C2=CC=CC(Cl)=C2. Product ID: ACM2505001545. Alfa Chemistry ISO 9001:2015 Certified.
SR18662 is a potent inhibitor of Krüppel-like factor five (KLF5) with an IC50 of 4.4 nM and an analogue of ML264 (HY-19994) with improved inhibitory potency against colorectal cancer cells. SR18662 can be used for the study of colorectal cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2505001-62-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-136530.
SR18662
SR18662 is an optimized anticancel agent based on ML264. SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo. SR18662 showed improved efficacy in reducing the viability of multiple colorectal cancer cell lines. Flow cytometry analysis following SR18662 treatment showed an increase in cells captured in either S or G2-M phases of the cell cycle and a significant increase in the number of apoptotic cells, the latter a unique property compared with ML264 or SR15006. SR18662 treatment also reduces the expression of cyclins and components of the MAPK and WNT signaling pathways. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SR18662; SR-18662; SR 18662. Product Category: Others. Appearance: Solid powder. CAS No. 2505001-62-5. Molecular formula: C16H19Cl2N3O4S. Mole weight: 420.31. Purity: >98%. IUPACName: (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide. Canonical SMILES: O=C(NCC(N1CCN(S(=O)(C)=O)CC1)=O)/C=C/C2=CC=C(Cl)C(Cl)=C2. Product ID: ACM2505001625. Alfa Chemistry ISO 9001:2015 Certified.
SR 202
SR 202. Group: Biochemicals. Grades: Purified. CAS No. 76541-72-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
SR2211 is a potent, selective synthetic ROR? modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1359164-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16998.
Potent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4- attenuation of human PMN chemotaxis. Group: Biochemicals. Alternative Names: 2-[[3- (2-Quinolinylmethoxy) phenyl]amino]benzoic acid hydrochloride. Grades: Highly Purified. CAS No. 146662-42-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
SR 27897. Group: Biochemicals. Grades: Purified. CAS No. 136381-85-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR-3029
SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with potent antiproliferative properties SR-3029 shoed IC50:= 97 nM in MTT assays against the human A375 melanoma cell line and have physical, in vitro and in vivo PK properties suitable for use in proof of principle animal xenograft studies against human cancer cell lines. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SR-3029; SR 3029; SR3029. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1454585-06-8. Molecular formula: C23H19F3N8O. Mole weight: 480.46. Purity: >98%. IUPACName: (6,7-Difluoro-1H-benzoimidazol-2-ylmethyl)-[9-(3-fluoro-phenyl)-2-morpholin-4-yl-9H-purin-6-yl]-amine. Canonical SMILES: FC1=CC(N2C=NC3=C(NCC4=NC5=CC=C(F)C(F)=C5N4)N=C(N6CCOCC6)N=C23)=CC=C1. Product ID: ACM1454585068. Alfa Chemistry ISO 9001:2015 Certified. Categories: SR 302 (VA).
SR-3029
SR-3029 is a potent and ATP competitive CK1? and CK1? inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases. Uses: Scientific research. Group: Signaling pathways. CAS No. 1454585-06-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100011.
SR-31747
SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 132173-07-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13751.
SR-318
SR-318 is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6.11 ?M for p38?, p38? and p38?/?, respectively. SR-318 potently inhibits the TNF-? release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2413286-32-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135674.
SR3335
SR3335 (ML 176) is a selective ROR? inverse agonist that directly binds to ROR? with a Ki of 220 nM[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ML 176. CAS No. 293753-05-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14413.
SR33805
SR33805 is a potent Ca 2+ channel antagonist, with EC 50 s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca 2+ channels. SR33805 can be used for the research of acute or chronic failing hearts [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 121345-64-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-136909.
SR 33805 oxalate
SR 33805 oxalate. Group: Biochemicals. Grades: Purified. CAS No. 121346-33-6. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
SR 3576
SR 3576. Group: Biochemicals. Grades: Purified. CAS No. 1164153-22-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
SR 48692. Group: Biochemicals. Grades: Purified. CAS No. 146362-70-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR 49059
SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a K i vaule of 1.4 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 150375-75-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18345.
SR 49059
SR 49059. Group: Biochemicals. Grades: Purified. CAS No. 150375-75-0. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
SR 57227A
SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC 50 ) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 77145-61-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-102064.