A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
SR 48692. Group: Biochemicals. Grades: Purified. CAS No. 146362-70-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR 49059
SR 49059. Group: Biochemicals. Grades: Purified. CAS No. 150375-75-0. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
SR 49059
SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a K i vaule of 1.4 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 150375-75-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18345.
SR 57227A
SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC 50 ) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 77145-61-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-102064.
SR 57227 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 77145-61-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR-58611
SR-58611. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (7S)-5,6,7,8-Tetrahydro-7-[[(R)-2-hydroxy-2-(3-chlorophenyl)ethyl]amino]-2-[(ethoxycarbonyl)methoxy]naphthalene;SR-58611;SR-58825A;amibegron. Product Category: Heterocyclic Organic Compound. CAS No. 121524-08-1. Molecular formula: C22H26ClNO4. Purity: 0.96. IUPACName: ethyl 2-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]acetate. Canonical SMILES: CCOC(=O)COC1=CC2=C(CCC(C2)NCC(C3=CC(=CC=C3)Cl)O)C=C1. Product ID: ACM121524081. Alfa Chemistry ISO 9001:2015 Certified. Categories: SR58611A.
SR-717 is an agonist of stimulator of interferon genes STING for treating cancer. SR-717 demonstrates broad interspecies and interallelic specificity. SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SR-717 lithium; SR 717 lithium; SR717 lithium. Product Category: Agonists. Appearance: Solid powder. CAS No. 2375421-09-1. Molecular formula: C15H8F2LiN5O3. Mole weight: 351.2. Purity: >98%. IUPACName: lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate. Canonical SMILES: O=C([O-])C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O.[Li+]. Product ID: ACM2375421091. Alfa Chemistry ISO 9001:2015 Certified.
SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC 50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1254944-66-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14415.
SR 8278
SR 8278. Group: Biochemicals. Alternative Names: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 1254944-66-5. Pack Sizes: 10mg. Molecular Formula: C18H19NO3S2, Molecular Weight: 361.48. US Biological Life Sciences.
Worldwide
SR9009
SR9009 is a REV-ERBα/β agonist with IC 50 s of 670 nM and 800 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1379686-30-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16989.
SR9011
SR9011 is a REV-ERBα / β agonist with IC 50 s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1379686-29-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16988.
SR9011 hydrochloride is a REV-ERBα / β agonist with IC 50 s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070014-94-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16988A.
SR95531 (Gabazine, GABAA Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531)
A selective, competitive antagonist of GABAA receptor (IC50 = 440nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100uM). Also shown to block glycine receptors, but with low affinity (Kb = 190uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 104104-50-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
SR 95531 hydrobromide
SR 95531 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 104104-50-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
The Src Inhibitor PP1, also referenced under CAS 172889-26-8, controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
Src Kinase Inhibitor I - CAS 179248-59-0
The Src Kinase Inhibitor I, also referenced under CAS 179248-59-0, controls the biological activity of Src Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
Src Kinase Inhibitor II - CAS 459848-35-2
The Src Kinase Inhibitor II, also referenced under CAS 459848-35-2, controls the biological activity of Src Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
SRF-DE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ChromoionophoreXIII,Semiphthorhodafluordecylester,DZ-49,7-[2-(Decyloxycarbonyl)-phenyl]-10-diethylamino-3-hydroxy-benzo[c]xanthyliumperchlorate. Product Category: Other Fluorophores. Appearance: Deep red powder. CAS No. 135656-96-1. Molecular formula: C38H44NO4·ClO4. Mole weight: 678.2. Purity: 95%+. IUPACName: [7-(2-decoxycarbonylphenyl)-3-hydroxybenzo[c]xanthen-10-ylidene]-diethylazanium;perchlorate. Canonical SMILES: CCCCCCCCCCOC(=O)C1=CC=CC=C1C2=C3C=CC(=[N+](CC)CC)C=C3OC4=C2C=CC5=C4C=CC(=C5)O.[O-]Cl(=O)(=O)=O. Product ID: ACM135656961-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: Sridevi.
SRI-011381
SRI-011381 is an orally active TGF-? signaling agonist, exhibits neuroprotective effects[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1629138-41-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100347.
SRI-011381 hydrochloride
SRI-011381 hydrochloride is an orally active TGF-? signaling agonist, exhibits neuroprotective effects[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070014-88-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100347A.
SRI-37330 is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 can be used for type 2 diabetes research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2322245-42-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142114.
SRI-37330 free base
SRI-37330 is a novel inhibitor of TXNIP expression, decreasing glucagon secretion and action and blocking hepatic glucose output, reversing obesity- and STZ-induced diabetes and hepatic steatosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SRI-37330 free base; SRI37330 free base, SRI 37330 free base. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2322245-42-9. Molecular formula: C16H19F3N4O2S. Mole weight: 388.41. Purity: >98%. IUPACName: N-((1-(6-(trifluoromethyl)quinazolin-4-yl)piperidin-3-yl)methyl)methanesulfonamide. Canonical SMILES: CS(=O)(NCC1CN(C2=C3C=C(C(F)(F)F)C=CC3=NC=N2)CCC1)=O. Product ID: ACM2322245429. Alfa Chemistry ISO 9001:2015 Certified.
SRI-37330 hydrochloride
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2322245-49-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-141623.
SRI-41315
SRI-41315 induces a prolonged pause at stop codons and suppresses PTCs (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613509-49-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150090.
SRI-42127
SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2727872-68-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148853.
S-ribosylhomocysteine lyase
Contains Fe2+. The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density. Group: Enzymes. Synonyms: S-ribosylhomocysteinase; LuxS. Enzyme Commission Number: EC 4.4.1.21. CAS No. 37288-63-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5323; S-ribosylhomocysteine lyase; EC 4.4.1.21; 37288-63-4; S-ribosylhomocysteinase; LuxS. Cat No: EXWM-5323.
SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 ?M for SRPK1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SRPK inhibitor. CAS No. 218156-96-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13949.
SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2089226-94-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-116856.
SRPK Inhibitor, SRPIN340 (N- (2-Piperidin-1-yl-5- (trifluoromethyl) phenyl) isonicotinamide, Serine-Arginine-Rich Protein Kinase Inhibitor, SR Protein Kinase Inhibitor, SR Protein Phosphorylation Inhibitor 340, (SRPIN)340)
A cell-permeable isonicotinamide that acts as an ATP-competitive SRPK1-selective inhibitor (IC50 = 0.14 and 1.8uM, respectively, against mSRPK1 and mSRPK2) with much reduced activity against 143 other kinases. Shown to effectively counteract IGF-1-induced anti-angiogenic to pro-angiogenic VEGF isoforms switch both in cultures in vitro (1h 10uM SRPIN340 prior to 12h IGF-1 stimulation of PCIPs) and in a murine hypoxia-induced retinal neovascularization model in vivo (10pmol/uL/eye intraocular SRPIN340 injection) by inhibiting PKC/SRPK signaling-dependent, alternate splicing factor ASF- (SF2; splicing factor 2) mediated VEGF pro-mRNA PSS (proximal splice site) selection. Suppresses RNA virus Sindbis propagation (IC50 = 60uM in Vero cultures) and HCV-JFH1 replication (1 & 10uM SRPIN340 in Huh7.5.1 cultures). Exhibits no toxicity toward rats (2g/kg p.o. for 2 wks), CHO (5mg/ml for 24h), or Huh7 (30uM for 48h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
SRT 1720 is a selective activator of human SIRT1 with an EC 1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC 1.5 s of 37 μM and > 300 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 925434-55-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10532.
SRT1720 - CAS 925434-55-5
SRT1720, CAS 925434-55-5, is a cell-permeable inhibitor of the mitochondrial SIRT3. Inhibition is AceCS2-competitive (Ki = 0.56 μM; Km = 2.44 μM), but NAD+-uncompetitive (Ki = 0.34 μM; Km = 280 μM). Group: Fluorescence/luminescence spectroscopy.
SRT 1720 dihydrochloride
SRT 1720 dihydrochloride is a selective and orally active activator of SIRT1 with an EC 50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2468639-77-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15145A.