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| Product | Description | |
|---|---|---|
| SV40 large T antigen NLS | SV40 large T antigen NLS, a hexamer protein generated from Large T antigen residue 47 to 55, enables protein import into cell nucleus. Synonyms: Cys-Gly-Gly-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Glu-Asp. Grades: ≥95%. Molecular formula: C58H104N20O18S. Mole weight: 1401.63. |  |
| SV-40 Large T-antigen Nuclear Localization Signal (NLS) | It is a commonly used nuclear localization signal (NLS) peptide, which is derived from Large T antigen residue 47 to 55. It enables protein import into cell nucleus. Synonyms: H-Cys-Gly-Gly-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Glu-Asp-OH; SV40 Large T-antigen Nuclear Localization Signal (NLS) derived peptide. Grades: ≥95%. Molecular formula: C58H104N20O18S. Mole weight: 1401.65. | |
| SV40 T-Ag-derived NLS peptide acetate | SV40 T-Ag-derived NLS peptide, derived from the Large T antigen residues 47 to 56, is the nuclear localization signal DNA tagged to this peptide, which is effectively translocated into the nucleus. Molecular formula: C68H115N19O20S. Mole weight: 1550.82. | |
| SVEC | SVEC. CAS No: 918822-70-5 |  Sarchem Laboratories New Jersey NJ |
| S-Venlafaxine | S-Venlafaxine. Group: Biochemicals. Alternative Names: 1-[ (1S) -2- (Dimethylamino) -1- (4-methoxyphenyl) ethyl]cyclohexanol; (-)-Venlafaxine. Grades: Highly Purified. CAS No. 93413-44-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C17H27NO2. US Biological Life Sciences. |  Worldwide |
| S-Venlafaxine-di-p-toluoyl-L-tartrate Salt | A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant. Group: Biochemicals. Grades: Highly Purified. CAS No. 272788-02-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| S-Verapamil HCl | S-Verapamil HCl is an inhibitor of the p-glycoprotein efflux pump in multidrug resistant tumor cells. Synonyms: (S)-(-)-Verapamil Hydrochloride; (α S) -α -[3-[[2- (3, 4-Dimethoxyphenyl) ethyl]methylamino]propyl]-3, 4-dimethoxy-α - (1-methylethyl) -benzeneacetonitrile Hydrochloride; (S)-Verapamil Hydrochloride; (-)-Verapamil Hydrochloride (α S) -α -[3-[[2- (3, 4-Dimethoxyphenyl) ethyl]methylamino]propyl]-3, 4-dimethoxy-α - (1-methylethyl) -benzeneacetonitrile Hydrochloride; (S)-Verapamil Hydrochloride; (-)-Verapamil Hydrochloride. CAS No. 36622-28-3. Molecular formula: C27H38N2O4. HCl. Mole weight: 491.07. | |
| SW02 | Heterocyclic Organic Compound. Alternative Names: CHEMBL404587, SW02, CCG-208770, 1010820-68-4, 4-(4-Bromophenyl)-5-(ethoxycarbonyl)-3,4-dihydro-6-methyl-2-oxo-1(2H)-pyrimidinebutanoic acid methyl ester. CAS No. 1010820-68-4. Molecular formula: C19H23BrN2O5. Mole weight: 439.3. Purity: 0.96. IUPACName: ethyl 6-(4-bromophenyl)-3-(4-methoxy-4-oxobutyl)-4-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate. Canonical SMILES: CCOC (=O)C1=C (N (C (=O)NC1C2=CC=C (C=C2)Br)CCCC (=O)OC)C. Catalog: ACM1010820684. |  |
| SW033291 | SW033291 is a potent and selective 15-hydroxyprostaglandin dehydrogenase (15-PGDH) enzyme inhibitor. SW033291 has been shown to promote hematopoietic recovery following murine transplant. Synonyms: SW-033291; SW 033291; 2-(butane-1-sulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridin-3-amine. Grades: >98%. CAS No. 459147-39-8. Molecular formula: C21H20N2OS3. Mole weight: 412.58. | |
| SW044248 | SW044248 is a potent and selective Topoisomerase I inhibitor. SW044248 killed approximately 15% of a panel of 74 NSCLC cell lines and was nontoxic to immortalized human bronchial cell lines. Synonyms: SW044248; SW-044248; SW 044248. Grades: 98%. CAS No. 522650-83-5. Molecular formula: C22H23N5O2S. Mole weight: 421.52. | |
| SW-100 | SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC 50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2126744-35-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-115475. |  |
| SW155246 | SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1) with IC50 value of 1.2 μM, displaying 30-fold selectivity for inhibition of human DNMT1 versus human or murine DNMT3A or -3B. It was shown to inhibit global methylation in HeLa cells, and reactivate expression of the tumor suppressor gene RASSF1A in A549 cells. Synonyms: 4-chloro-N-(4-hydroxynaphthalen-1-yl)-3-nitrobenzenesulfonamide. Grades: ≥98%. CAS No. 420092-79-1. Molecular formula: C16H11ClN2O5S. Mole weight: 378.8. | |
| SW-163A | SW-163A is an immunosuppressant isolated from the culture broth of Streptomyces sp. SNA15896. It showed immunosuppressive and antimicrobial activities in vitro. Synonyms: SW-163 A. Molecular formula: C34H42N2O12. Mole weight: 670.7. | |
| SW-163B | SW-163B is an immunosuppressant isolated from the culture broth of Streptomyces sp. SNA15896. It showed immunosuppressive and antimicrobial activities in vitro. Synonyms: SW-163 B. Molecular formula: C33H40N2O12. Mole weight: 656.7. | |
| SW-163C | SW-163C is an antitumor depsipeptide produced by Streptomyces sp. SNA15896. The LD50 of SW-163C is > 100 mg/kg. Synonyms: SW-163 C. Molecular formula: C52H60N10O14S2. Mole weight: 1113.2. | |
| SW-163E | SW-163E is an antitumor depsipeptide produced by Streptomyces sp. SNA15896. The LD50 of SW-163E is 0.6 mg/kg. Synonyms: SW-163 E. Molecular formula: C54H64N10O14S2. Mole weight: 1141.3. | |
| SW1 Granulated Seaweed | Seaweed Granules. Uses: Agriculture, horticulture, amenity & animal feed. Alternative Names: Soil improver & animal feed supplements. Grades: High. Pack Sizes: 500KG. Molecular formula: Fertilizer. Sold wholesale for blending & formulating. Categories: Seaweed granules, algae, Soil Conditioners. |  |
| SW1+ Pure granular seaweed meal with beneficial soil microbes | Seaweed Granules with beneficial soil microbes. Uses: Agriculture, horticulture, amenity. Alternative Names: Soil improver. Pack Sizes: 500KG. Molecular formula: Fertilizer. Sold wholesale for blending & formulating. Categories: Seaweed granules, algae, Soil Conditioners. | |
| SW203668 trifluoroacetate salt | SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines. Synonyms: SW203668 TFA; 4-(aminophenylmethyl)-N-(6-methoxy-2-benzothiazolyl)-benzamide trifluoroacetate salt. Grades: ≥98%. CAS No. 2117405-48-6. Molecular formula: C22H19N3O2S·CF3COOH. Mole weight: 503.49. | |
| SW2 Refined seaweed granules | Refined Seaweed Granules. Uses: Agriculture, horticulture, amenity. Alternative Names: Soil improver. Pack Sizes: 500KG. Molecular formula: Fertilizer with greater water holding capacity. Categories: Seaweed granules, algae, Soil Conditioners. | |
| SW2+ Refined seaweed granules with beneficial soil microbes | Refined Seaweed Granule with beneficial soil microbes. Uses: Agriculture, horticulture, amenity. Alternative Names: Soil improver. Pack Sizes: 500KG. Molecular formula: Fertilizer with greater water holding capacity. Categories: Seaweed granules, algae, Soil Conditioners. | |
| SW480 Cell Lysate, LiCl-treated | Western Blot positive control cell lysate for C2069-48D. Cell lysate from SW480 cells. Serum starved cells were treated for 15min with LiCl. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
| Swainsonine | Swainsonine. Group: Biochemicals. Grades: Purified. CAS No. 72741-87-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Swainsonine | Potent and specific inhibitor of α-mannosidase II with IC50 in submicromolar range. It inhibits three α-mannosidase II isoforms; MAN2A1 in Golgi apparatus, MAN2B1 in lysosomes and MAN2C1 in endoplasmatic reticulum. The compound reduces tumour growth and metastasis in mice by increasing the mannose content in N-linked glycans and directing the cell towards apoptosis. Group: Other alkaloids. Alternative Names: (1S, 2R, 8R, 8αR)-1, 2, 3, 5, 6, 7, 8, 8α-Octahydroindolizine-1, 2, 8-triolTridolgosir. CAS No. 72741-87-8. Molecular formula: C8H15NO3. Mole weight: 173.21 g/mol. Appearance: White to faint yellow powder. Purity: 0.98. IUPACName: (1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,2,8-triol. Canonical SMILES: C1C[C@H] ([C@@H]2[C@@H] ([C@@H] (CN2C1)O)O)O. Density: 1.38±0.1 g/ml. Catalog: ACM72741878-1. | |
| Swainsonine | Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Tridolgosir. CAS No. 72741-87-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6722. | |
| Swainsonine (8a,b-Octahydroindolizidine-1a,2a,8b-triol) | Swainsonine is a plant alkaloid derived from Swainsona canes. Group: Biochemicals. Alternative Names: 8a,b-Octahydroindolizidine-1a,2a,8b-triol. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Swalpamycin | Swalpamycin is a 16-membered ring macrolide antibiotic produced by Str.sp.Y-84, 30967. Activity against gram-positive bacteria. Synonyms: Oxacyclohexadeca-3,11,13-triene-2,10-dione, 15-(((6-deoxy-2,3-di-O-methyl-beta-D-allopyranosyl)oxy)methyl)-6-(((4S,5R,6R,7S,9R)-6-hydroxy-4,9-dimethyl-2-oxo-1,3,8-trioxaspiro(4.5)dec-7-yl)oxy)-5,7,9,16-tetramethyl-, (3E,5S,6S,7S,9R,11E,13E,15R,16R)-. Grades: >98%. CAS No. 112008-27-2. Molecular formula: C37H56O14. Mole weight: 724.83. | |
| SWCNT | SWCNT. Group: Single wall cnt. CAS No. 308068-56-6. >98% (SWNT). |  |
| SWCNT (Amino Functional Group) | SWCNT (Amino Functional Group). Group: Single wall cnt. >80% (SWCNT). | |
| SWCNT COOH | SWCNT COOH. Group: Single wall cnt. >95% (SWNT). | |
| SWCNT Dispersion | SWCNT Dispersion. Group: Oxide nano dispersioncnt nano dispersion. CAS No. 308068-56-6. Mole weight: SWCNT. >96%. | |
| SWCNT Hydroxyl Conjugation | SWCNT Hydroxyl Conjugation. Group: Single wall cnt. >80% (SWNT). | |
| SWCNTs | SWCNTs. Group: Single wall cnt. CAS No. 308068-56-6. Molecular formula: 12.01g/mol. Mole weight: C. | |
| SWCNT Water Dispersion | SWCNT Water Dispersion. Group: Oxide nano dispersioncnt nano dispersion. CAS No. 308068-56-6. Mole weight: SWCNT. >99.99%. | |
| SWCNT Water Dispersion | SWCNT Water Dispersion. Group: Single wall cnt. | |
| Sweet Almond Oil | Sweet Almond Oil. CAS No. 8007-69-0. Kosher: Y. VIGON Item # 507696. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers, Cosmetics. |  America & Internationally |
| Sweet Basil Leaf Powder(Ocimum Basilicum) | Sweet Basil Leaf Powder(Ocimum Basilicum). |  CA, FL & NJ |
| Sweeteners | Our wide distribution network, with locations coast-to-coast, helps guarantee fast, reliable service to Univar's customers. |  |
| Sweet Marjoram Oil 100% Pure | Sweet Marjoram Oil 100% Pure. CAS No. 8015-01-8. FEMA No. 2663. VIGON Item # 510184. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers, Cosmetics, Aromatherapy, Essetial Oils. | America & Internationally |
| Sweet Orange Essential Oil, USDA Certified Organic | Organic, all-natural sweet orange essential oil (citrus sinensis). Cold pressed from the peel. Used in a wide array of cosmetic & food products for fragrance and flavor. Phthalate-free. Uses: All kinds of personal care products and cosmetics including lip care products. Group: Sensory modifiers. CAS No. 8008-57-9. Appearance: Yellow to orange liquid, characteristic odor. Catalog: CI-SC-0165. | |
| Sweet potato powder | Sweet potato powder. Applications: Sweet potatoes have certain health effects: first, there is the sweet potato anticancer effects. second, sweet potato good for the heart. third, the white sweet potato have anti-diabetic effects. fourth, the sweet potato is an ideal diet food. Group: Others. Appearance: This product is white powder, with a fresh, sweet aroma realistic unique flavor. Source: The sweet potato or kumara (Ipomoea batatas) is a dicotyledonous plant that belongs to the family Convolvulaceae.Its large, starchy, sweet-tasting, tuberous roots are a root vegetable. The young leaves and shoots are sometimes eaten as greens. Sweet potato powder. Cat No: EXTC-212. |  |
| Sweet Wormwood (Artemisia Annua) P.E. > 99% Artemisinin HPLC | Sweet Wormwood (Artemisia Annua) P.E. > 99% Artemisinin HPLC. | CA, FL & NJ |
| Sweroside | Sweroside. Group: Biochemicals. Grades: Plant Grade. CAS No. 14215-86-2. Pack Sizes: 20mg. Molecular Formula: C16H22O9, Molecular Weight: 358.34. US Biological Life Sciences. | Worldwide |
| Sweroside | Sweroside, isolated from Lonicera japonica, exhibits cytoprotective, anti-osteoporotic, and hepatoprotective effect [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 14215-86-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0806. | |
| Sweroside, 6'-O- β-D-apiofuranosyl- | Sweroside, 6'-O- β-D-apiofuranosyl-. Group: Biochemicals. Grades: Plant Grade. CAS No. 266678-59-5. Pack Sizes: 2mg. Molecular Formula: C21H30O13, Molecular Weight: 490.46. US Biological Life Sciences. | Worldwide |
| Swertiajaponin | Swertiajaponin. Group: Biochemicals. Grades: Plant Grade. CAS No. 6980-25-2. Pack Sizes: 5mg. Molecular Formula: C22H22O11, Molecular Weight: 462.41. US Biological Life Sciences. | Worldwide |
| Swertiamarin | Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP , and NF-κB , and promote osteoblast proliferation. Swertiamarin has antioxidant and hepatoprotective effects against carbon tetrachloride induced rat liver toxicity through the Nrf2/HO-1 pathway. Swertiamarin can attenuate inflammatory mediators by regulating JAK2/STAT3 transcription factors in adjuvant induced arthritis rats. Swertiamarin can be used in the research of diabetes and arthritis [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 17388-39-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0807. | |
| Swertiamarin | Swertiamarin. Group: Biochemicals. Alternative Names: Swertiamaroside. Grades: Plant Grade. CAS No. 17388-39-5. Pack Sizes: 20mg. Molecular Formula: C16H22O10, Molecular Weight: 374.34. US Biological Life Sciences. | Worldwide |
| Swertianin | Swertianin. Group: Biochemicals. Alternative Names: Gentiakochianin; Gentiachochianin. Grades: Plant Grade. CAS No. 20882-75-1. Pack Sizes: 20mg. Molecular Formula: C14H10O6, Molecular Weight: 274.226. US Biological Life Sciences. | Worldwide |
| Swertianin | Swertianin is found in the herbs of Gentiana bavarica, it has potential anti-inflammatory and antinoceceptive which could be used as a drug candidate against inflammation related conditions. Synonyms: Gentiakochianin; 1,2,8-Trihydroxy-6-methoxy-9H-xanthen-9-one. Grades: > 95%. CAS No. 20882-75-1. Molecular formula: C14H10O6. Mole weight: 274.23. | |
| Swertianolin | Swertianolin, a xanthone isolated from Gentianella Acuta, inhibits acetylcholinesterase (AChE). Swertianolin also exhibits anti-HBV and anti-bacterial activity. Group: Inhibitors. Alternative Names: 5,8-Dihydroxy-3-methoxyxanthone-1-o-glucoside. CAS No. 23445-00-3. Molecular formula: C20H20O11. Mole weight: 436.37. Purity: 98%+. Catalog: ACM23445003. | |
| Swertianolin | Botanical Source: Group: Biochemicals. Grades: Plant Grade. CAS No. 23445-00-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Swertiaperennin | Swertiaperennin is a xanthone isolated from Swertia bimaculata. Synonyms: Methylswertianin; 1,8-Dihydroxy-2,6-dimethoxy-9H-xanthen-9-one; 2-O-Methylswertianin. Grades: 98%. CAS No. 22172-17-4. Molecular formula: C15H12O6. Mole weight: 288.25. | |
| Swertisin | Swertisin. Group: Biochemicals. Grades: Plant Grade. CAS No. 6991-10-2. Pack Sizes: 10mg. Molecular Formula: C22H22O10, Molecular Weight: 446.41. US Biological Life Sciences. | Worldwide |
| Swertisin | Swertisin efficiently changed the morphology of NIH3T3 cells from fibroblastic to round aggregate cell cluster in huge numbers. Dithizone (DTZ) stain primarily confirmed differentiation and gene expression studies signified rapid onset of differentiation signaling cascade in Swertisin-induced ILCC. Synonyms: Flavocommelitin; 6-C-glucopyranosyl-7-O-methylapigenin; Apigenin 6-glucosyl-7-O-methyl ether. Grades: >98%. CAS No. 6991-10-2. Molecular formula: C22H22O10. Mole weight: 446.4. | |
| Swinholide A | Swinholide A, isolated from the marien sponge Theonella swinhoei, is a 44-carbon ring dimeric dilactone macrolide with a 2-fold axis of symmetry. Recent studies have elucidated its unusual structure and shown that it has potent cytotoxic activity. We now report that swinholide A disrupts the actin cytoskeleton of cells grown in culture, sequesters actin dimers in vitro in both polymerizing and non-polymerizing buffers with a binding stoichiometry of one swinholide A molecule per actin dimer, and rapidly severs F-actin in vitro with high cooperativity. These unique properties are sufficient to explain the cytotoxicity of swinholide A. They also suggest that swinholide A might be a model for studies of the mechanism of action of F-actin severing proteins and be therapeutically useful in conditions where filamentous actin contributes to pathologically high viscosities. Group: Biochemicals. Grades: Highly Purified. CAS No. 95927-67-6. Pack Sizes: 10ug, 50ug. US Biological Life Sciences. | Worldwide |
| SWNT Carbon Nanotubes | SWNT Carbon Nanotubes. Group: Single wall cnt. CAS No. 308068-56-6. >80% (SWNT). | |
| SWNTs (60%, 1-2 nm) | SWNTs (60%, 1-2 nm). Group: Single wall cnt. | |
| SWNTs(Functionalized) | SWNTs(Functionalized). Group: Single wall cnt. >90wt%. | |
| SX 011 | SX 011 is a potent p38α inhibitor (IC50 = 9 nM). It also acts as a p38β and JNK-2 inhibitor (IC50 = 90 nM and 100 nM, respectively). SX 011 exhibits no significant activity at p38γ, p38δ, ERK-2 and JNK-1. Synonyms: SX 011; SX011; SX-011; 6-Chloro-5-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]carbonyl-N,N,1-trimethyl-α-oxo-1H-indole-3-acetamide. Grades: ≥98% by HPLC. CAS No. 309913-42-6. Molecular formula: C26H27ClFN3O3. Mole weight: 483.96. | |
| SX 011 | SX 011. Group: Biochemicals. Grades: Purified. CAS No. 309913-42-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SX-682 | SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1648843-04-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119339. | |
| SYBR Green I | SYBR Green I is a fluorescent probe used for staining double stranded DNA or oligonucleotides in agarose or polyacrylamide gels. Synonyms: N,N-dimethyl-N'-[4-[(E)-(3-methyl-1,3-benzothiazol-2-ylidene)methyl]-1-phenylquinolin-1-ium-2-yl]-N'-propylpropane-1,3-diamine; Nucleic acid gel stain. CAS No. 163795-75-3. Molecular formula: C32H37N4S. Mole weight: 509.73. | |
| SYBR Green II | SYBR Green II is a fluorescent nucleic acid dye that mainly binds single-stranded nucleotides. SYBR Green II is sensitive to oligonucleotides or larger nucleic acid polymers in a variety of cells and gels. SYBR Green II can be used to study cell structure, membrane integrity or function, and cell cycle distribution. Wavelength 484/515 nm [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 195199-08-7. Pack Sizes: 50 μL. Product ID: HY-D1098. | |
| Sydowinin B | Sydowinin B is a xanthone polyketide originally isolated from A. sydowii and has immunosuppressant activity. It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 19.2 and 20.8 μg/ml, respectively). Synonyms: MS-347b. Grades: >95% by HPLC. CAS No. 58450-00-3. Molecular formula: C16H12O7. Mole weight: 316.26. | |
| SYHA1813 | SYHA1813 is a dual inhibitor of CSF1R and VEGFR. SYHA1813 has potent antitumor activity against GBM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1807466-30-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161025. | |
| Syk Inhibitor II | Syk inhibitor II is a cell-permeable, ATP-competitive inhibitor of Syk (IC50 = 41 nM). It also exhibits less potent inhibitory effects against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively). Synonyms: Spleen Tyrosine Kinase Inhibitor II; 2- ( (2-Aminoethyl) amino) -4- ( (3- (trifluoromethyl) phenyl) amino) pyrimidine-5-carboxamide. Grades: ≥98%. CAS No. 726695-51-8. Molecular formula: C14H15F3N6O. Mole weight: 340.3. | |
| Syk Inhibitor II hydrochloride | Syk inhibitor II is a cell-permeable, ATP-competitive inhibitor of Syk (IC50 = 41 nM). It also exhibits less potent inhibitory effects against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively). Synonyms: Spleen Tyrosine Kinase Inhibitor II; Syk Inhibitor II 2HCl; Syk Inhibitor II dihydrochloride; 2-(2-aminoethylamino)-4-[3-(trifluoromethyl)anilino]pyrimidine-5-carboxamide dihydrochloride. Grades: ≥98%. CAS No. 227449-73-2. Molecular formula: C14H15F3N6O·2HCl. Mole weight: 413.2. | |
| Syk Inhibitor VI, R406 (N4-(2,2-Dimethyl-3-oxo-4H-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine, 6- (5-Fluoro-2- (3, 4, 5-trimethoxyphenylamino) pyrimidin-4-ylamino) -2, 2-dimethyl-2H-pyrido[3, 2-b][1, 4]oxazin-3 (4H) -one) | A cell-permeable, orally bioavailable pyrimidinediamino compound with anti-inflammatory and anti-tumor properties. Acts as a potent, reversible and ATP-competitive inhibitor of Syk kinase (IC50 = 41nM; Ki = 30nM). Exhibits high selectivity over a broad panel of other protein kinases (300nM), ion channels, and enzymes. Blocks Syk-dependent FcR-mediated activation of monocytes/macrophages, and neutrophils and inhibits Anti-IgE-mediated degranulation in cultured human mast cells (EC50 = 56nM as measured by tryptase release). At higher concentrations, it is shown to block adenosine A3 receptors, adenosine transporter, and monoamine transporter (IC50 = 81nM, 1.84uM, and 2.74uM, respectively), and Flt3 autophosphorylation. Shown to reduce immune complex-mediated inflammation in murine models (10mg/kg) and diminish airway hyper-responsiveness in asthma models. Group: Biochemicals. Grades: Highly Purified. CAS No. 841290-80-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Syk Inhibitor V ( (S) -2- (2- ( (3, 5-dimethylphenyl) amino) pyrimidin-4-yl) -N- (1-hydroxypropan-2-yl) -4-methylthiazole-5-carboxamide, Spleen Tyrosine Kinase Inhibitor) | A cell-permeable, 4-thiazolyl-2-phenylaminopyrimidine compound that acts as a potent, reversible, and ATP-competitive inhibitor of spleen tyrosine kinase (Syk) (Ki=9nM). Exhibits excellent selectivity over Cdk2 (Ki=3.33uM), ROCK (Ki=2.3uM), Src (Ki=3.33uM), and ZAP70 (Ki=240nM). Shown to inhibit mast cell degranulation (IC50=70nM) that is commonly observed in asthma and other allergic diseases. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 397.5. US Biological Life Sciences. | Worldwide |
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