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| Product | Description | |
|---|---|---|
| Aldose reductase from Human, Recombinant | In enzymology, aldose reductase (or aldehyde reductase) (EC 1.1.1.21) is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose metabolism. Group: Enzymes. Synonyms: Aldehyde reductase; Aldo-keto reductase family 1 member B1. Enzyme Commission Number: EC 1.1.1.21. CAS No. 9028-31-3. Aldose reductase. Mole weight: 35853.4 Da. Source: Human. Aldehyde reductase; Aldo-keto reductase family 1 member B1; EC 1.1.1.21; Aldose reductase. Cat No: NATE-1198. |  |
| Aldose reductase-IN-1 | Aldose reductase-IN-1, an aldose reductase inhibitor, could have potential biological usage in the study of breast cancer. IC50: 28.9 pM. Uses: Aldose reductase-in-1 is an aldose reductase inhibitor that could have potential biological usage in the study of breast cancer. Synonyms: Aldose reductase-IN-1; SCHEMBL359604; CS-5128; HY-18967; AT-001; CS 5128; HY 18967; AT 001; CS5128; HY18967; AT001. Grade: 98%. CAS No. 1355612-71-3. Molecular formula: C17H10F3N5O3S. Mole weight: 421.35. |  |
| aldose-6-phosphate reductase (NADPH) | In the reverse reaction, acts also on D-galactose 6-phosphate and, more slowly, on D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate. Group: Enzymes. Synonyms: aldose 6-phosphate reductase; NADP-dependent aldose 6-phosphate reductase; A6PR; aldose-6-P reductase; aldose-6-phosphate reductase; alditol 6-phosphate:NADP 1-oxidoreductase; aldose-6-phosphate reductase (NADPH2). Enzyme Commission Number: EC 1.1.1.200. CAS No. 76901-04-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0105; aldose-6-phosphate reductase (NADPH); EC 1.1.1.200; 76901-04-7; aldose 6-phosphate reductase; NADP-dependent aldose 6-phosphate reductase; A6PR; aldose-6-P reductase; aldose-6-phosphate reductase; alditol 6-phosphate:NADP 1-oxidoreductase; aldose-6-phosphate reductase (NADPH2). Cat No: EXWM-0105. | |
| 1,2-Dimethyl-hydrazine Dihydrochloride | 1,2-Dimethylhydrazine is a potent carcinogen that acts as a DNA alkylating agent. It is used to induce colon tumors in experimental animals. It was also used in preparation of spiroisoquinolinedione aldose reductase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 306-37-6. Pack Sizes: 2.5g, 5g. Molecular Formula: C2H10Cl2N2, Molecular Weight: 133.02. US Biological Life Sciences. |  Worldwide |
| 1-(4-Fluorobenzyl)-2-chlorobenzimidazole | 2-Chloro-1-(4-fluorobenzyl)benzimidazole is an aldose reductase (ALR2) inhibitor. Synonyms: 1-(4-Fluorobenzyl)-2-chlorobenzimidazole. Grade: 98 %. CAS No. 84946-20-3. Molecular formula: C14H10ClFN2. Mole weight: 260.69. | |
| 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) | This enzyme is present in some but not all Rhizobium species and belongs in the GFO/IDH/MocA protein family. This enzyme differs from hepatic 1,5-anhydro-D-fructose reductase, which yields 1,5-anhydro-D-glucitol as the product (see EC 1.1.1.263). In Sinorhizobium morelense, the product of the reaction, 1,5-anhydro-D-mannitol, can be further metabolized to D-mannose. The enzyme also reduces 1,5-anhydro-D-erythro-hexo-2,3-diulose and 2-ketoaldoses (called osones), such as D-glucosone (D-arabino-hexos-2-ulose) and 6-deoxy-D-glucosone. It does not reduce common aldoses and ketoses, or non-sugar aldehydes and ketones. Group: Enzymes. Synonyms: 1,5-anhydro-D-fructose reductase (ambiguous); AFR. Enzyme Commission Number: EC 1.1.1.292. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0201; 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming); EC 1.1.1.292; 1,5-anhydro-D-fructose reductase (ambiguous); AFR. Cat No: EXWM-0201. | |
| 1,5-Anhydro-D-galactitol | 1,5-Anhydro-D-galactitol, a versatile biomedicine widely employed in managing complications associated with diabetes and ocular cataracts, exhibits exceptional capacity in inhibiting aldose reductase. This enzymatic inhibition effectively hampers the intracellular accumulation of sorbitol. By curbing sorbitol levels, this remarkable compound substantially alleviates diabetic retinopathy and initiates the amelioration of nerve impairments. Moreover, due to its inherent properties, 1,5-Anhydro-D-galactitol showcases promising prospects as a beneficial supplement to the food and pharmaceutical sectors, augmenting its applicability in a multifaceted manner. CAS No. 3971-48-0. Molecular formula: C6H12O5. Mole weight: 164.16. | |
| 1-Cyanotetraline | 1-Cyanotetraline is used in the synthesis of aldose reductase inhibitors. Also reductase enzymes are believed to catalyze the formation of sorbitol from glucose leading to the chronic complications of diabetes mellitus. It is also used in the synthesis of baclofen analogs, potent GABAB agonists. Group: Biochemicals. Alternative Names: 1, 2, 3, 4-Tetrahydro-1-naphthalene carbonitrile; 1,2,3,4-Tetrahydro-1-naphthonitrile; 1, 2, 3, 4-Tetrahydro-1-naphthalene carbonitrile; 1-Cyano-1,2,3,4-tetrahydronaphthalene; 1-Cyanotetralin. Grades: Highly Purified. CAS No. 56536-96-0. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 1-Deoxy-1-nitro-L-galactitol | 1-Deoxy-1-nitro-L-galactitol, a remarkable biomedicine marvel, aims to revolutionize the field of diabetes treatment. By diligently impeding the activity of the enzyme aldose reductase, its profound impact on mitigating the genesis of diabetic complications cannot be overstated. Synonyms: D-Galactitol, 6-deoxy-6-nitro-. CAS No. 94481-72-8. Molecular formula: C6H13NO7. Mole weight: 211.17. | |
| 1-Deoxy-D-sorbose | 1-Deoxy-D-sorbose, a remarkable biomedical substance, presents itself as a promising therapeutic tool in the management of diabetes. By means of obstructing the action of aldose reductase, a pivotal enzyme implicated in diabetic complications, this compound adeptly modulates blood glucose levels. Synonyms: Methylxylose; D-Sorbose, 1-deoxy-. CAS No. 64520-56-5. Molecular formula: C6H12O5. Mole weight: 164.16. | |
| 20(S)-Ginsenoside Rg2 | 20(S)-Ginsenoside Rg2 is used as an aldose reductase inhibitor and my exert anti-inflammatory and immunomodulatory activity. It exists as a bioactive metabolite of the ginsenoside component of Panax ginseng. Group: Biochemicals. Grades: Highly Purified. CAS No. 52286-74-5. Pack Sizes: 50mg, 500mg. Molecular Formula: C42H72O13. US Biological Life Sciences. | Worldwide |
| 2-[[1-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid | 2-[[1-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 260784-21-2. Pack Sizes: 100mg, 1g. Molecular Formula: C16H11NO4S2, Molecular Weight: 345.39. US Biological Life Sciences. | Worldwide |
| 2-[2, 4-dibromo-6-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]phenoxy]-acetic Acid | 2-[2, 4-dibromo-6-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]phenoxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 123021-81-8. Pack Sizes: 50mg, 500mg. Molecular Formula: C12H7Br2NO4S2, Molecular Weight: 453.13. US Biological Life Sciences. | Worldwide |
| 2-[2, 4-dichloro-6-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]phenoxy]-acetic Acid | 2-[2, 4-dichloro-6-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]phenoxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 123021-78-3. Pack Sizes: 100mg, 1g. Molecular Formula: C12H7Cl2NO4S2, Molecular Weight: 364.22. US Biological Life Sciences. | Worldwide |
| 2-[[2-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-1-naphthalenyl]oxy]-acetic Acid | 2-[[2-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-1-naphthalenyl]oxy]-acetic Acid is an analog of 2-[[1-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid (O859575). 2-[[1-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 1348775-25-6. Pack Sizes: 25mg, 250mg. Molecular Formula: C16H11NO4S2, Molecular Weight: 345.39. US Biological Life Sciences. | Worldwide |
| 2,3,4,6-Tetrakis-O-(phenylmethyl)- β-D-glucopyranose 1-[3, 4, 5-Tris (phenylmethoxy) benzoate] | 2,3,4,6-Tetrakis-O-(phenylmethyl)- β-D-glucopyranose 1-[3, 4, 5-Tris (phenylmethoxy) benzoate] is an protected intermediate in the synthesis of β-Glucogallin (G416000), a novel aldose reductase (ALR2) inhibitor, one of the factors regulating the secondary complications arising from diabetes mellitus. Group: Biochemicals. Grades: Highly Purified. CAS No. 1195367-79-3. Pack Sizes: 25mg, 50mg. Molecular Formula: C62H58O10. US Biological Life Sciences. | Worldwide |
| 2-[[6-Bromo-1-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid | 2-[[6-bromo-1-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 123021-42-1. Pack Sizes: 50mg, 500mg. Molecular Formula: C16H10BrNO4S2, Molecular Weight: 424.29. US Biological Life Sciences. | Worldwide |
| 2,6-Dibromoquinone | 2,6-Dibromoquinone is a reagent used in the preparation of halodiphenyl ether derivatives which has human aldose reductase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 19643-45-9. Pack Sizes: 100mg, 1g. Molecular Formula: C6H2Br2O2. US Biological Life Sciences. | Worldwide |
| 2-Bromo-5-fluoro-4-methylanisole | 2-Bromo-5-fluoro-4-methylanisole is being used in studies for the design and preparation of (arylcarbamoylphenoxy) acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications. Group: Biochemicals. Grades: Highly Purified. CAS No. 314298-15-2. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H8BrFO, Molecular Weight: 219.05. US Biological Life Sciences. | Worldwide |
| 2-Chloro-1- (4-fluorobenzyl) benzimidazole | A novel aldose reductase (ALR2) inhibitor. It is used for preparation of disubstituted benzimidazole derivative as anti-allergic agent (Mizolastine). Group: Biochemicals. Grades: Highly Purified. CAS No. 84946-20-3. Pack Sizes: 1g, 10g, 25g. Molecular Formula: C??H??ClFN?. US Biological Life Sciences. | Worldwide |
| (2Z)-2-Methyl-3-phenyl-2-propenal | (2Z)-2-Methyl-3-phenyl-2-propenal (Epalrestat Impurity 2) is an impurity of Epalrestat (E565300), an aldose reductase inhibitor used to treat diabetic neuropathy. Group: Biochemicals. Grades: Highly Purified. CAS No. 66051-14-7. Pack Sizes: 100mg, 500mg. Molecular Formula: C10H10O, Molecular Weight: 146.19. US Biological Life Sciences. | Worldwide |
| 2-((Z)-5-((E)-2-methyl-3-phenylallylidene)-2,4-dioxothiazolidin-3-yl)acetic acid | An impurity of Epalrestat, a carboxylic acid-based inhibitor of aldose reductase. Synonyms: 2-[5-((2E)-2-methyl-3-phenylprop-2-enylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]a cetic acid. CAS No. 794510-29-5. Molecular formula: C15H13NO4S. Mole weight: 303.3. | |
| 3-(4-Chlorophenyl)-1,2,4-oxadiazole-5-butanoic Acid | An aldose reductase inhibitor. Group: Biochemicals. Alternative Names: 4-[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]butanoic Acid. Grades: Highly Purified. CAS No. 439108-15-3. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| 3-Deoxy-3-fluoro-D-galactitol | 3-Deoxy-3-fluoro-D-galactitol is an exceptional biomedical compound, specifically designed to study the complex nature of hereditary galactosemia. Employing its extraordinary competitive inhibitory potential against aldose reductase, this remarkable compound effectively curtails the deleterious buildup of galactitol. Synonyms: (2R,3S,4R,5S)-4-Fluorohexane-1,2,3,5,6-pentaol. CAS No. 1241800-31-6. Molecular formula: C6H13FO5. Mole weight: 184.16. | |
| (3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinone | (3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinone is a biomedically relevant substance used in pharmaceutical formulations. It helps in diabetes management by serving as a potent inhibitor of human aldose reductase, a key enzyme involved in pathogenic complications of diabetes. Molecular formula: C5H9NO4. Mole weight: 147.13. | |
| 5-Methoxyindole-3-acetonitrile-d2 | 5-Methoxyindole-3-acetonitrile-d2 is a labelled analogue of 5-Methoxyindole-3-acetonitrile (M262818), which is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors. 5-Methoxyindole-3-acetonitrile-d2 is also an intermediate in synthesizing Melatonin-d4 (M215002), a hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation / metastasis of breast cancer cells by inhibiting estrogen receptor action. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C11H8D2N2O. US Biological Life Sciences. | Worldwide |
| [(5Z)-5-benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid | An impurity of Epalrestat. Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM. Synonyms: (5-Benzylidene-4-oxo-2-thioxo-thiazolidin-3-yl)-acetic acid; (Z)-2-(5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)acetic acid; Epalrestat Impurity 1. Grade: ≥95%. CAS No. 82159-06-6. Molecular formula: C12H9NO3S2. Mole weight: 279.33. | |
| 6-Deoxy-L-galactitol | 6-Deoxy-L-galactitol, a sugar alcohol, exhibits promising therapeutic capabilities for the management of diabetic complications. Its ability to manipulate aldose reductase, an enzyme that transfigures glucose to sorbitol impedes the accumulation of sorbitol in cells. Furthermore, studies suggest it could potentially be used as an anti-inflammatory and antioxidant agent. Synonyms: Fucitol, L-; Galactitol, 1-deoxy-, D-; 6-Deoxy-L-galactitol; L-Fucitol; L-Galactitol, 6-deoxy-; NSC 1957. CAS No. 13074-06-1. Molecular formula: C6H14O5. Mole weight: 166.17. | |
| 6-Hydroxyluteolin | 6-Hydroxyluteolin (Compound 17) is a flavonoid compound. 6-Hydroxyluteolin has an inhibitory effect on aldose reductase (AR) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 18003-33-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151231. |  |
| aldehyde reductase | Has wide specificity. Group: Enzymes. Synonyms: aldose reductase; polyol dehydrogenase (NADP+); ALR2; alditol:NADP oxidoreductase; alditol:NADP+ 1-oxidoreductase; NADPH-aldopentose reductase; NADPH-aldose reductase. Enzyme Commission Number: EC 1.1.1.21. CAS No. 9028-31-3. Aldose reductase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0114; aldehyde reductase; EC 1.1.1.21; 9028-31-3; aldose reductase; polyol dehydrogenase (NADP+); ALR2; alditol:NADP oxidoreductase; alditol:NADP+ 1-oxidoreductase; NADPH-aldopentose reductase; NADPH-aldose reductase. Cat No: EXWM-0114. | |
| Alrestatin | Alrestatin is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AY-22284. CAS No. 51411-04-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1202. | |
| Alrestatin | Alrestatin is an inhibitor of aldose reductase (IC50 = 148 μM). Uses: Specific inhibitor of aldose reductase. Synonyms: Alrestatine; 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid. Grade: ≥98%. CAS No. 51411-04-2. Molecular formula: C14H9NO4. Mole weight: 255.23. | |
| Alrestatin (sodium) | Alrestatin sodium is a specific inhibitor of aldose reductase (IC50 = 148 μM). Uses: A specific inhibitor of aldose reductase. Synonyms: Sodium; 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetate. Grade: ≥98%. CAS No. 51876-97-2. Molecular formula: C14H8NNaO4. Mole weight: 277.21. | |
| Asperaldin | Asperaldin is an aldose reductase (ECLLL21) inhibitor produced by Aspergillus niger CFR-1046. Synonyms: 1,4-Naphthalenedione, 8-(hexyloxy)-2,6-dihydroxy-. CAS No. 561297-46-9. Molecular formula: C16H18O5. Mole weight: 290.31. | |
| β-Glucogallin | β-Glucogallin is a potent and selective aldose reductase (AKR1B1) inhibitor. β-Glucogallin can be isolated from the medicinal plant Emblica officinalis [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 1-O-Galloyl-β-D-glucose. CAS No. 13405-60-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-133708. | |
| Byakangelicin | Byakangelicin is an effective inhibitor of sex hormones and affects the catabolism of endogenous hormones. It directly affects the cytochrome P450 isoform (CY) P3A4 in human hepatocytes. It is an inhibitor of aldose reductase used in the treatment of diabetic cataracts. Byakangelicin is a natural coumarin compound found in Murraya koenigii, Triphasia trifoliata, and other organisms. Synonyms: 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(2R)-2,3-dihydroxy-3-methylbutoxy]-4-methoxy-; 7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-, (R)-; 9-[(2R)-2,3-Dihydroxy-3-methylbutoxy]-4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one; Biacangelicin; (+)-Byakangelicin; 5-Methoxy-8-(2,3-dihydroxy-3-methylbutoxy)psoralene; Bjacangelicin; Bjakangelicin; Byankagelicine. Grade: >98%. CAS No. 482-25-7. Molecular formula: C17H18O7. Mole weight: 334.32. | |
| Caficrestat | Caficrestat (Aldose reductase-IN-1) is a inhibitor of aldose reductase with IC 50 of 28.9 pM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Aldose reductase-IN-1; AT-001. CAS No. 1355612-71-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18967. | |
| CP-744809 | CP-744809 is a highly selective orally available small molecule inhibitor of aldose reductase. Uses: Aldose reductase inhibitor. Synonyms: CP-744809; CP744809; CP 744809; ARI-809; ARI 809; ARI809; UNII-U63F8E95J1. 6-((5-chloro-3-methyl-2-benzofuranyl)sulfonyl)-3(2H)-Pyridazinone. Grade: ≥98%. CAS No. 463976-07-0. Molecular formula: C13H9ClN2O4S. Mole weight: 324.74. | |
| Cuminaldehyde | Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase ( IC 50 = 0.00085 mg/mL), α-glucosidase ( IC 50 =0.5 mg/mL) and lipoxygenase ( IC 50 =1370 μM). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. Alternative Names: p-Isopropylbenzaldehyde. CAS No. 122-03-2. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-Y0790. | |
| DL-Glyceraldehyde-[1,2,3,3'-d4] | DL-Glyceraldehyde-[1,2,3,3'-d4] is the labelled analogue of DL-Glyceraldehyde, which is the simplest of all aldoses and has been shown to be the one of the carbonyl metabolites of dietary fructose. It is a substrate for the enzyme aldose reductase. Synonyms: DL-[1,2,3,3'-2H4]glyceraldehyde; DL-[1,2,3,3'-2H4]2,3-dihydroxypropanal; DL-glyceraldehyde-1,2,3,3-d4; (±)-2,3-Dihydroxy-propanal-1,2,3,3-d4; (±)-Glyceraldehyde-1,2,3,3-d4; 2,3-Dihydroxypropanal-1,2,3,3-d4; 2,3-Dihydroxypropionaldehyde-1,2,3,3-d4; α,β-Dihydroxypropionaldehyde-1,2,3,3-d4. CAS No. 478529-62-3. Molecular formula: C3H2D4O3. Mole weight: 94.10. | |
| DL-Glyceraldehyde-[1-d] | DL-Glyceraldehyde-[1-d] is the labelled analogue of DL-Glyceraldehyde, which is the simplest of all aldoses and has been shown to be the one of the carbonyl metabolites of dietary fructose. It is a substrate for the enzyme aldose reductase. Synonyms: DL-Glyceraldehyde-1-d; (±)-2,3-Dihydroxypropanal-1-d; 2,3-Dihydroxypropanal-1-d; 2,3-Dihydroxypropionaldehyde-1-d; DL-Glyceric aldehyde-1-d; Glyceraldehyde-1-d; Glyceric Aldehyde-1-d; Glycerinaldehyde-1-d; Glycerose-1-d; NSC 67934-1-d; α,β-Dihydroxypropionaldehyde-1-d; DL-[1-2H]glyceraldehyde; DL-[1-2H]2,3-dihydroxypropanal. Grade: ≥90%. CAS No. 72599-69-0. Molecular formula: C3H5DO3. Mole weight: 91.08. | |
| D-Lyxose-[1-13C] | One of the labelled D-Lyxose. D-Lyxose is the C'-2 epimer of D-xylose. It is used in molecular model calculations for drug binding and recognition studies related to aldose reductase. Synonyms: D-[1-13C]lyxose. CAS No. 70849-22-8. Molecular formula: C4[13C]H10O5. Mole weight: 151.12. | |
| D-lyxose-[1,2-13C2] | One of the labelled D-Lyxose. D-Lyxose is the C'-2 epimer of D-xylose. It is used in molecular model calculations for drug binding and recognition studies related to aldose reductase. Synonyms: D-[1,2-13C2]lyxose; D-lyxose-1,2-13C2. Molecular formula: C3[13C]2H10O5. Mole weight: 152.11. | |
| D-Lyxose-[2-13C] | One of the labelled D-Lyxose. D-Lyxose is the C'-2 epimer of D-xylose. It is used in molecular model calculations for drug binding and recognition studies related to aldose reductase. CAS No. 83379-39-9. Molecular formula: C4[13C]H10O5. Mole weight: 151.12. | |
| D-Lyxose-[2-d1] | One of the labelled D-Lyxose. D-Lyxose is the C'-2 epimer of D-xylose. It is used in molecular model calculations for drug binding and recognition studies related to aldose reductase. Synonyms: D-[2-2H]lyxose; D-lyxose-2-d; D-[2-D]lyxose. Molecular formula: C5H9DO5. Mole weight: 151.14. | |
| D-Lyxose-[3-13C] | One of the labelled D-Lyxose. D-Lyxose is the C'-2 epimer of D-xylose. It is used in molecular model calculations for drug binding and recognition studies related to aldose reductase. Synonyms: D-[3-13C]lyxose; D-lyxose-3-13C. Molecular formula: C4[13C]H10O5. Mole weight: 151.12. | |
| D-lyxose-[4-13C] | One of the labelled D-Lyxose. D-Lyxose is the C'-2 epimer of D-xylose. It is used in molecular model calculations for drug binding and recognition studies related to aldose reductase. Synonyms: D-[4-13C]lyxose; D-lyxose-4-13C. Molecular formula: C4[13C]H10O5. Mole weight: 151.12. | |
| D-Lyxose-[5-13C] | One of the labelled D-Lyxose. D-Lyxose is the C'-2 epimer of D-xylose. It is used in molecular model calculations for drug binding and recognition studies related to aldose reductase. CAS No. 139657-61-7. Molecular formula: C4[13C]H10O5. Mole weight: 151.12. | |
| D-lyxose-[UL-13C5] | One of the labelled D-Lyxose. D-Lyxose is the C'-2 epimer of D-xylose. It is used in molecular model calculations for drug binding and recognition studies related to aldose reductase. Synonyms: D-[UL-13C5]lyxose; D-lyxose-1,2,3,4,5-13C5. Molecular formula: [13C]5H10O5. Mole weight: 155.09. | |
| EBPC | A highly specific aldose reductase inhibitor that has been shown to enhance HeLa cell sensitivity to chemotherapeutic drugs. Group: Biochemicals. Alternative Names: 2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester; 1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester; NSC 229530; CP-10668. Grades: Highly Purified. CAS No. 4450-98-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| EBPC | EBPC is a potent and selective aldose reductase inhibitor. It is used to improve the cytotoxicity of anticancer reagents such as cisplatin and doxorubicin in HeLa cervical carcinoma cells via an increase in ERK activity. Synonyms: Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate; 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester; MFCD00179167; 1-benzyl-4-[ethoxy(hydroxy)methylidene]pyrrolidine-2,3-dione. Grade: ≥99% by HPLC. CAS No. 4450-98-0. Molecular formula: C14H15NO4. Mole weight: 261.28. | |
| Engeletin | Engeletin is a flavonoid glycoside isolated from the leaves of Engelhardtia roxburghiana Wall. It inhibits a recombinant human aldose reductase. Uses: Anti-inflammatory. Synonyms: Dihydrokaempferol 3-O-a-L-rhamnopyranoside; Engelitin; (2R,3R)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-3-yl 6-deoxy-a-L-mannopyranoside. Grade: 96.5%. CAS No. 572-31-6. Molecular formula: C21H22O10. Mole weight: 434.39. | |
| Epalrestat | An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy. Group: Biochemicals. Alternative Names: (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic Acid. Grades: Highly Purified. CAS No. 82159-09-9. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Epalrestat | Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM. Uses: Enzyme inhibitors. Synonyms: Kinedak; ONO-2235; ONO 2235; ONO2235; Sorbistat; (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid; 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (Z,E)-; 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propenylidene]-4-oxo-2-thioxo-, (5Z)-; 2-[(Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl]acetic acid; Eabeth. Grade: >98%. CAS No. 82159-09-9. Molecular formula: C15H13NO3S2. Mole weight: 319.40. | |
| Epalrestat | Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ONO2235. CAS No. 82159-09-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-66009. | |
| Epalrestat-[d5] | One of the isotope labelled form of Epalrestat, which is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: (5Z)-5-[(2E)-2-Methyl-3-phenyl-d5-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic Acid; Eabeth-d5; Kinedak-d5; ONO 2235-d5; Sorbistat-d5; Epalrestat-d5; 2-[(Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl]acetic acid-d5. Grade: >95%. Molecular formula: C15H8NO3S2D5. Mole weight: 324.43. | |
| Epalrestat Dimer | A dimer impurity of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: Dimer of 5Z-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. Grade: >95%. Molecular formula: C30H26N2O6S4. Mole weight: 638.81. | |
| Epalrestat (E,E)-Isomer | A stereoisomer of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: (5E)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid; 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propenylidene]-4-oxo-2-thioxo-, (5E)-; 2-((E)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid. Grade: >95%. CAS No. 863988-85-6. Molecular formula: C15H13NO3S2. Mole weight: 319.40. | |
| Epalrestat (E,Z)-Isomer | A stereoisomer of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: (5E)-5-[(2Z)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid; 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,Z)-; 3-Thiazolidineacetic acid, 5-[(2Z)-2-methyl-3-phenyl-2-propenylidene]-4-oxo-2-thioxo-, (5E)-; (E,Z)-5-(2-Methyl-3-phenyl-2-propen-1-ylidene)-4-oxo-2-thioxo-3-thiazolidineacetic Acid; 2-((E)-5-((Z)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid. Grade: >95%. CAS No. 124782-64-5. Molecular formula: C15H13NO3S2. Mole weight: 319.40. | |
| Epalrestat (Z,Z)-Isomer | It is a stereoisomer of Epalrestat, an aldose reductase inhibitor with IC50 of 72 nM. Synonyms: 2-[(5Z)-5-[(2Z)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid; (5Z)-5-[(2Z)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid; 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (Z,Z)-; 3-Thiazolidineacetic acid, 5-[(2Z)-2-methyl-3-phenyl-2-propenylidene]-4-oxo-2-thioxo-, (5Z)-; (Z,Z)-5-(2-Methyl-3-phenyl-propenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic Acid. Grade: >95%. CAS No. 124782-63-4. Molecular formula: C15H13NO3S2. Mole weight: 319.40. | |
| Exisulind | Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac [1]. Exisulind inhibits aldose reductase with an IC 50 of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 59864-04-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-13633. | |
| Fidarestat | Fidarestat is a aldose reductase inhibitor originated by Sanwa Kagaku Kenkyusho. It was very effective in significantly alleviating some symptoms of diabetic polyneuropathy. Long-term treatment with SNK-860 has a beneficial preventive effect on the development of experimental diabetic neuropathy. In addition, Fidarestat is also a promising drug targeting autophagy in Colorectal Carcinoma. Uses: Diabetic neuropathies. Synonyms: SNK860; SNK-860; SNK 860; SK860; SK-860; SK 860; Fidarestat; Aldos. (2S,4S)-6-fluoro-2',5'-dioxospiro[chromane-4,4'-imidazolidine]-2-carboxamide; Aldos; SNK 860. Grade: 98%. CAS No. 136087-85-9. Molecular formula: C12H10FN3O4. Mole weight: 279.23. | |
| Fidarestat | Fidarestat (SNK 860) is an inhibitor of aldose reductase , with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SNK 860. CAS No. 136087-85-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-105185. | |
| FR-62765 | FR-62765, a derivative of WF-3681, is a novel aldose reductase inhibitor. It might be a useful drug for diabetic neuropathy. Uses: Fr-62765 might be a useful drug for diabetic neuropathy. Synonyms: FR 62765; FR-62765; FR62765. 2-Furanpropanoic acid, 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-, ethyl ester; FR62765; 2,5-Dihydro-4-methoxy-5-oxo-3-phenylfuran-2-propanoic acid ethyl ester; Ethyl 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-2-furanpropanoate; Ethyl 3-(4-methoxy-5-oxo-3-phenyl-2H-furan-2-yl)propanoate. Grade: >98 %. CAS No. 105346-34-7. Molecular formula: C16H18O5. Mole weight: 290.31. | |
| Govorestat | Govorestat (AT-007) is an orally active brain-penetrant aldose reductase inhibitor with an IC 50 value of 100 pM. Govorestat has the potential for galactose-1-phosphate uridyl transferase deficiency research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AT-007. CAS No. 2170729-29-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-129586. | |
| Govorestat | Govorestat is an aldose reductase inhibitor developed for the treatment of galactosemia. Synonyms: AT-007; AT 007; AT007. Grade: 98% by HPLC. CAS No. 2170729-29-8. Molecular formula: C17H10F3N3O3S2. Mole weight: 425.4. | |
| Isoliquiritigenin | Isoliquiritigenin, a flavonoid from the root of Glycyrrhiza glabrat, inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μm. It has antioxidant, anti-inflammatory, and anti-tumor activities. Uses: Antidiabetic; antitumour; antioxidant; anti-inflammatory; antimutagenic; antifungal. Synonyms: (2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one; ISL; 2',4,4'-Trihydroxychalcone; GU 17; 6'-deoxychalcone; 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-; trans-2',4,4'-trihydroxychalcone. Grade: >98%. CAS No. 961-29-5. Molecular formula: C15H12O4. Mole weight: 256.25. | |
| Isoliquiritigenin | Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2',4,4'-Trihydroxy-trans-chalcone. Product Category: Inhibitors. Appearance: Yellow to orange powder. CAS No. 961-29-5. Molecular formula: C15H12O4. Mole weight: 256.25. Purity: 0.98. IUPACName: (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one. Canonical SMILES: C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O. Density: 1.384±0.06 g/cm³. Product ID: ACM961295. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Isoliquiritigenin | Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC 50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC 50 of 24.7 μM. Uses: Scientific research. Group: Natural products. Alternative Names: GU17; ISL; Isoliquiritigen; SJ000286237. CAS No. 961-29-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-N0102. | |
| L-lyxose-[1-13C] | One of the labelled D-Lyxose. D-Lyxose is the C'-2 epimer of D-xylose. It is used in molecular model calculations for drug binding and recognition studies related to aldose reductase. Synonyms: L-[1-13C]lyxose; L-lyxose-1-13C. Molecular formula: C4[13C]H10O5. Mole weight: 151.12. | |
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