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| Product | Description | |
|---|---|---|
| Aldose reductase from Human, Recombinant | In enzymology, aldose reductase (or aldehyde reductase) (EC 1.1.1.21) is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose metabolism. Group: Enzymes. Synonyms: Aldehyde reductase; Aldo-keto reductase family 1 member B1. Enzyme Commission Number: EC 1.1.1.21. CAS No. 9028-31-3. Aldose reductase. Mole weight: 35853.4 Da. Source: Human. Aldehyde reductase; Aldo-keto reductase family 1 member B1; EC 1.1.1.21; Aldose reductase. Cat No: NATE-1198. |  |
| Aldose reductase-IN-1 | Aldose reductase-IN-1, an aldose reductase inhibitor, could have potential biological usage in the study of breast cancer. IC50: 28.9 pM. Uses: Aldose reductase-in-1 is an aldose reductase inhibitor that could have potential biological usage in the study of breast cancer. Synonyms: Aldose reductase-IN-1; SCHEMBL359604; CS-5128; HY-18967; AT-001; CS 5128; HY 18967; AT 001; CS5128; HY18967; AT001. Grades: 98%. CAS No. 1355612-71-3. Molecular formula: C17H10F3N5O3S. Mole weight: 421.35. |  |
| aldose-6-phosphate reductase (NADPH) | In the reverse reaction, acts also on D-galactose 6-phosphate and, more slowly, on D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate. Group: Enzymes. Synonyms: aldose 6-phosphate reductase; NADP-dependent aldose 6-phosphate reductase; A6PR; aldose-6-P reductase; aldose-6-phosphate reductase; alditol 6-phosphate:NADP 1-oxidoreductase; aldose-6-phosphate reductase (NADPH2). Enzyme Commission Number: EC 1.1.1.200. CAS No. 76901-04-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0105; aldose-6-phosphate reductase (NADPH); EC 1.1.1.200; 76901-04-7; aldose 6-phosphate reductase; NADP-dependent aldose 6-phosphate reductase; A6PR; aldose-6-P reductase; aldose-6-phosphate reductase; alditol 6-phosphate:NADP 1-oxidoreductase; aldose-6-phosphate reductase (NADPH2). Cat No: EXWM-0105. | |
| 1,2-Dimethyl-hydrazine Dihydrochloride | 1,2-Dimethylhydrazine is a potent carcinogen that acts as a DNA alkylating agent. It is used to induce colon tumors in experimental animals. It was also used in preparation of spiroisoquinolinedione aldose reductase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 306-37-6. Pack Sizes: 2.5g, 5g. Molecular Formula: C2H10Cl2N2, Molecular Weight: 133.02. US Biological Life Sciences. |  Worldwide |
| 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) | This enzyme is present in some but not all Rhizobium species and belongs in the GFO/IDH/MocA protein family. This enzyme differs from hepatic 1,5-anhydro-D-fructose reductase, which yields 1,5-anhydro-D-glucitol as the product (see EC 1.1.1.263). In Sinorhizobium morelense, the product of the reaction, 1,5-anhydro-D-mannitol, can be further metabolized to D-mannose. The enzyme also reduces 1,5-anhydro-D-erythro-hexo-2,3-diulose and 2-ketoaldoses (called osones), such as D-glucosone (D-arabino-hexos-2-ulose) and 6-deoxy-D-glucosone. It does not reduce common aldoses and ketoses, or non-sugar aldehydes and ketones. Group: Enzymes. Synonyms: 1,5-anhydro-D-fructose reductase (ambiguous); AFR. Enzyme Commission Number: EC 1.1.1.292. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0201; 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming); EC 1.1.1.292; 1,5-anhydro-D-fructose reductase (ambiguous); AFR. Cat No: EXWM-0201. | |
| 1,5-Anhydro-D-galactitol | 1,5-Anhydro-D-galactitol, a versatile biomedicine widely employed in managing complications associated with diabetes and ocular cataracts, exhibits exceptional capacity in inhibiting aldose reductase. This enzymatic inhibition effectively hampers the intracellular accumulation of sorbitol. By curbing sorbitol levels, this remarkable compound substantially alleviates diabetic retinopathy and initiates the amelioration of nerve impairments. Moreover, due to its inherent properties, 1,5-Anhydro-D-galactitol showcases promising prospects as a beneficial supplement to the food and pharmaceutical sectors, augmenting its applicability in a multifaceted manner. CAS No. 3971-48-0. Molecular formula: C6H12O5. Mole weight: 164.16. | |
| 1-Cyanotetraline | 1-Cyanotetraline is used in the synthesis of aldose reductase inhibitors. Also reductase enzymes are believed to catalyze the formation of sorbitol from glucose leading to the chronic complications of diabetes mellitus. It is also used in the synthesis of baclofen analogs, potent GABAB agonists. Group: Biochemicals. Alternative Names: 1, 2, 3, 4-Tetrahydro-1-naphthalene carbonitrile; 1,2,3,4-Tetrahydro-1-naphthonitrile; 1, 2, 3, 4-Tetrahydro-1-naphthalene carbonitrile; 1-Cyano-1,2,3,4-tetrahydronaphthalene; 1-Cyanotetralin. Grades: Highly Purified. CAS No. 56536-96-0. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 1-Deoxy-1-nitro-L-galactitol | 1-Deoxy-1-nitro-L-galactitol, a remarkable biomedicine marvel, aims to revolutionize the field of diabetes treatment. By diligently impeding the activity of the enzyme aldose reductase, its profound impact on mitigating the genesis of diabetic complications cannot be overstated. Synonyms: 1-Deoxy-1-nitro-L-galactitol; 94481-72-8; (2S,3R,4S,5R)-6-NITROHEXANE-1,2,3,4,5-PENTOL; GEO-04691; J-200016; W-204109; (2S,3R,4S,5R)-6-nitrohexane-1,2,3,4,5-pentaol. CAS No. 94481-72-8. Molecular formula: C6H13NO7. Mole weight: 211.17. | |
| 1-Deoxy-D-sorbose | 1-Deoxy-D-sorbose, a remarkable biomedical substance, presents itself as a promising therapeutic tool in the management of diabetes. By means of obstructing the action of aldose reductase, a pivotal enzyme implicated in diabetic complications, this compound adeptly modulates blood glucose levels. Synonyms: methylxylose. Molecular formula: C6H12O5. Mole weight: 164.16. | |
| 20(S)-Ginsenoside Rg2 | 20(S)-Ginsenoside Rg2 is used as an aldose reductase inhibitor and my exert anti-inflammatory and immunomodulatory activity. It exists as a bioactive metabolite of the ginsenoside component of Panax ginseng. Group: Biochemicals. Grades: Highly Purified. CAS No. 52286-74-5. Pack Sizes: 50mg, 500mg. Molecular Formula: C42H72O13. US Biological Life Sciences. | Worldwide |
| 2-[[1-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid | 2-[[1-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 260784-21-2. Pack Sizes: 100mg, 1g. Molecular Formula: C16H11NO4S2, Molecular Weight: 345.39. US Biological Life Sciences. | Worldwide |
| 2-[2, 4-dibromo-6-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]phenoxy]-acetic Acid | 2-[2, 4-dibromo-6-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]phenoxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 123021-81-8. Pack Sizes: 50mg, 500mg. Molecular Formula: C12H7Br2NO4S2, Molecular Weight: 453.13. US Biological Life Sciences. | Worldwide |
| 2-[2, 4-dichloro-6-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]phenoxy]-acetic Acid | 2-[2, 4-dichloro-6-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]phenoxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 123021-78-3. Pack Sizes: 100mg, 1g. Molecular Formula: C12H7Cl2NO4S2, Molecular Weight: 364.22. US Biological Life Sciences. | Worldwide |
| 2-[[2-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-1-naphthalenyl]oxy]-acetic Acid | 2-[[2-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-1-naphthalenyl]oxy]-acetic Acid is an analog of 2-[[1-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid (O859575). 2-[[1-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 1348775-25-6. Pack Sizes: 25mg, 250mg. Molecular Formula: C16H11NO4S2, Molecular Weight: 345.39. US Biological Life Sciences. | Worldwide |
| 2,3,4,6-Tetrakis-O-(phenylmethyl)- β-D-glucopyranose 1-[3, 4, 5-Tris (phenylmethoxy) benzoate] | 2,3,4,6-Tetrakis-O-(phenylmethyl)- β-D-glucopyranose 1-[3, 4, 5-Tris (phenylmethoxy) benzoate] is an protected intermediate in the synthesis of β-Glucogallin (G416000), a novel aldose reductase (ALR2) inhibitor, one of the factors regulating the secondary complications arising from diabetes mellitus. Group: Biochemicals. Grades: Highly Purified. CAS No. 1195367-79-3. Pack Sizes: 25mg, 50mg. Molecular Formula: C62H58O10. US Biological Life Sciences. | Worldwide |
| 2-[[6-Bromo-1-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid | 2-[[6-bromo-1-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 123021-42-1. Pack Sizes: 50mg, 500mg. Molecular Formula: C16H10BrNO4S2, Molecular Weight: 424.29. US Biological Life Sciences. | Worldwide |
| 2,6-Dibromoquinone | 2,6-Dibromoquinone is a reagent used in the preparation of halodiphenyl ether derivatives which has human aldose reductase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 19643-45-9. Pack Sizes: 100mg, 1g. Molecular Formula: C6H2Br2O2. US Biological Life Sciences. | Worldwide |
| 2-Bromo-5-fluoro-4-methylanisole | 2-Bromo-5-fluoro-4-methylanisole is being used in studies for the design and preparation of (arylcarbamoylphenoxy) acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications. Group: Biochemicals. Grades: Highly Purified. CAS No. 314298-15-2. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H8BrFO, Molecular Weight: 219.05. US Biological Life Sciences. | Worldwide |
| 2-Chloro-1- (4-fluorobenzyl) benzimidazole | A novel aldose reductase (ALR2) inhibitor. It is used for preparation of disubstituted benzimidazole derivative as anti-allergic agent (Mizolastine). Group: Biochemicals. Grades: Highly Purified. CAS No. 84946-20-3. Pack Sizes: 1g, 10g, 25g. Molecular Formula: C??H??ClFN?. US Biological Life Sciences. | Worldwide |
| (2Z)-2-Methyl-3-phenyl-2-propenal | (2Z)-2-Methyl-3-phenyl-2-propenal (Epalrestat Impurity 2) is an impurity of Epalrestat (E565300), an aldose reductase inhibitor used to treat diabetic neuropathy. Group: Biochemicals. Grades: Highly Purified. CAS No. 66051-14-7. Pack Sizes: 100mg, 500mg. Molecular Formula: C10H10O, Molecular Weight: 146.19. US Biological Life Sciences. | Worldwide |
| 2-((Z)-5-((E)-2-methyl-3-phenylallylidene)-2,4-dioxothiazolidin-3-yl)acetic acid | An impurity of Epalrestat, a carboxylic acid-based inhibitor of aldose reductase. Synonyms: 2-[5-((2E)-2-methyl-3-phenylprop-2-enylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]a cetic acid. CAS No. 794510-29-5. Molecular formula: C15H13NO4S. Mole weight: 303.3. | |
| 3-(4-Chlorophenyl)-1,2,4-oxadiazole-5-butanoic Acid | An aldose reductase inhibitor. Group: Biochemicals. Alternative Names: 4-[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]butanoic Acid. Grades: Highly Purified. CAS No. 439108-15-3. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| 3-Deoxy-3-fluoro-D-galactitol | 3-Deoxy-3-fluoro-D-galactitol is an exceptional biomedical compound, specifically designed to study the complex nature of hereditary galactosemia. Employing its extraordinary competitive inhibitory potential against aldose reductase, this remarkable compound effectively curtails the deleterious buildup of galactitol. Synonyms: 3-Deoxy-3-fluoro-D-glucitol; 3-Deoxy-3-fluoro-D-galactitol; 864720-85-4; 34339-82-7; (2R,3R,4S,5R)-4-Fluorohexane-1,2,3,5,6-pentol; AKOS006271586; (2R,3R,4S,5R)-4-fluorohexane-1,2,3,5,6-pentaol. Molecular formula: C6H13FO5. Mole weight: 184.16. | |
| (3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinone | (3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinone is a biomedically relevant substance used in pharmaceutical formulations. It helps in diabetes management by serving as a potent inhibitor of human aldose reductase, a key enzyme involved in pathogenic complications of diabetes. Molecular formula: C5H9NO4. Mole weight: 147.13. | |
| 5-Methoxyindole-3-acetonitrile-d2 | 5-Methoxyindole-3-acetonitrile-d2 is a labelled analogue of 5-Methoxyindole-3-acetonitrile (M262818), which is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors. 5-Methoxyindole-3-acetonitrile-d2 is also an intermediate in synthesizing Melatonin-d4 (M215002), a hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation / metastasis of breast cancer cells by inhibiting estrogen receptor action. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C11H8D2N2O. US Biological Life Sciences. | Worldwide |
| 6-Deoxy-L-galactitol | 6-Deoxy-L-galactitol, a sugar alcohol, exhibits promising therapeutic capabilities for the management of diabetic complications. Its ability to manipulate aldose reductase, an enzyme that transfigures glucose to sorbitol impedes the accumulation of sorbitol in cells. Furthermore, studies suggest it could potentially be used as an anti-inflammatory and antioxidant agent. Synonyms: 1-deoxy-d-galactitol; (2R,3S,4R,5S)-hexane-1,2,3,4,5-pentol. CAS No. 13074-06-1. Molecular formula: C6H14O5. Mole weight: 166.17. | |
| 6-Hydroxyluteolin | 6-Hydroxyluteolin (Compound 17) is a flavonoid compound. 6-Hydroxyluteolin has an inhibitory effect on aldose reductase (AR) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 18003-33-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151231. |  |
| aldehyde reductase | Has wide specificity. Group: Enzymes. Synonyms: aldose reductase; polyol dehydrogenase (NADP+); ALR2; alditol:NADP oxidoreductase; alditol:NADP+ 1-oxidoreductase; NADPH-aldopentose reductase; NADPH-aldose reductase. Enzyme Commission Number: EC 1.1.1.21. CAS No. 9028-31-3. Aldose reductase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0114; aldehyde reductase; EC 1.1.1.21; 9028-31-3; aldose reductase; polyol dehydrogenase (NADP+); ALR2; alditol:NADP oxidoreductase; alditol:NADP+ 1-oxidoreductase; NADPH-aldopentose reductase; NADPH-aldose reductase. Cat No: EXWM-0114. | |
| Alrestatin | Alrestatin is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AY-22284. CAS No. 51411-04-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1202. | |
| Alrestatin | Alrestatin is an inhibitor of aldose reductase (IC50 = 148 μM). Uses: Specific inhibitor of aldose reductase. Synonyms: Alrestatine; 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid. Grades: ≥98%. CAS No. 51411-04-2. Molecular formula: C14H9NO4. Mole weight: 255.23. | |
| Alrestatin (sodium) | Alrestatin sodium is a specific inhibitor of aldose reductase (IC50 = 148 μM). Uses: A specific inhibitor of aldose reductase. Synonyms: Sodium;2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetate. Grades: ≥98%. CAS No. 51876-97-2. Molecular formula: C14H8NNaO4. Mole weight: 277.21. | |
| Asperaldin | Asperaldin is an aldose reductase (ECLLL21) inhibitor produced by Aspergillus niger CFR-1046. Synonyms: 1,4-Naphthalenedione, 8-(hexyloxy)-2,6-dihydroxy-. CAS No. 561297-46-9. Molecular formula: C16H18O5. Mole weight: 290.31. | |
| β-Glucogallin | β-Glucogallin is a potent and selective aldose reductase (AKR1B1) inhibitor. β-Glucogallin can be isolated from the medicinal plant Emblica officinalis [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 1-O-Galloyl-β-D-glucose. CAS No. 13405-60-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-133708. | |
| Caficrestat | Caficrestat (Aldose reductase-IN-1) is a inhibitor of aldose reductase with IC 50 of 28.9 pM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Aldose reductase-IN-1; AT-001. CAS No. 1355612-71-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18967. | |
| CP-744809 | CP-744809 is a highly selective orally available small molecule inhibitor of aldose reductase. Uses: Aldose reductase inhibitor. Synonyms: CP-744809; CP744809; CP 744809; ARI-809; ARI 809; ARI809; UNII-U63F8E95J1. 6-((5-chloro-3-methyl-2-benzofuranyl)sulfonyl)-3(2H)-Pyridazinone. Grades: ≥98%. CAS No. 463976-07-0. Molecular formula: C13H9ClN2O4S. Mole weight: 324.74. | |
| Cuminaldehyde | Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase ( IC 50 = 0.00085 mg/mL), α-glucosidase ( IC 50 =0.5 mg/mL) and lipoxygenase ( IC 50 =1370 μM). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. Alternative Names: p-Isopropylbenzaldehyde. CAS No. 122-03-2. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-Y0790. | |
| EBPC | A highly specific aldose reductase inhibitor that has been shown to enhance HeLa cell sensitivity to chemotherapeutic drugs. Group: Biochemicals. Alternative Names: 2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester; 1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester; NSC 229530; CP-10668. Grades: Highly Purified. CAS No. 4450-98-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| EBPC | EBPC is a potent and selective aldose reductase inhibitor. It is used to improve the cytotoxicity of anticancer reagents such as cisplatin and doxorubicin in HeLa cervical carcinoma cells via an increase in ERK activity. Synonyms: Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate; 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester; MFCD00179167; 1-benzyl-4-[ethoxy (hydroxy)methylidene]pyrrolidine-2, 3-dione. Grades: ≥99% by HPLC. CAS No. 4450-98-0. Molecular formula: C14H15NO4. Mole weight: 261.28. | |
| Epalrestat | An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy. Group: Biochemicals. Alternative Names: (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic Acid. Grades: Highly Purified. CAS No. 82159-09-9. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Epalrestat | Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM. Uses: Enzyme inhibitors. Synonyms: Epalrestat; Kinedak; ONO-2235; ONO 2235; ONO2235; Sorbistat. Grades: >98%. CAS No. 82159-09-9. Molecular formula: C15H13NO3S2. Mole weight: 319.4. | |
| Epalrestat | Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ONO2235. CAS No. 82159-09-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-66009. | |
| Epalrestat Dimer | Dimer impurity of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: Dimer of 5Z-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. Grades: > 95%. Molecular formula: C30H26N2O6S4. Mole weight: 638.81. | |
| Epalrestat (E, E)-Isomer | A stereoisomer of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: 2-((Z)-5-((Z)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid. Grades: > 95%. Molecular formula: C15H13NO3S2. Mole weight: 319.40. | |
| Epalrestat (E, Z)-Isomer | A stereoisomer of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: (E,Z)-5-(2-Methyl-3-phenyl-2-propen-1-ylidene)-4-oxo-2-thioxo-3-thiazolidineacetic Acid. Grades: > 95%. Molecular formula: C15H13NO3S2. Mole weight: 319.40. | |
| Epalrestat (Z, Z)-Isomer | A stereoisomer of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: 2-((Z)-5-((Z)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid. Grades: > 95%. Molecular formula: C15H13NO3S2. Mole weight: 319.40. | |
| Exisulind | Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac [1]. Exisulind inhibits aldose reductase with an IC 50 of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 59864-04-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-13633. | |
| Fidarestat | Fidarestat is a aldose reductase inhibitor originated by Sanwa Kagaku Kenkyusho. It was very effective in significantly alleviating some symptoms of diabetic polyneuropathy. Long-term treatment with SNK-860 has a beneficial preventive effect on the development of experimental diabetic neuropathy. In addition, Fidarestat is also a promising drug targeting autophagy in Colorectal Carcinoma. Uses: Diabetic neuropathies. Synonyms: SNK860; SNK-860; SNK 860; SK860; SK-860; SK 860; Fidarestat; Aldos. (2S,4S)-6-fluoro-2',5'-dioxospiro[chromane-4,4'-imidazolidine]-2-carboxamide; Aldos;SNK 860. Grades: 98%. CAS No. 136087-85-9. Molecular formula: C12H10FN3O4. Mole weight: 279.23. | |
| Fidarestat | Fidarestat (SNK 860) is an inhibitor of aldose reductase , with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SNK 860. CAS No. 136087-85-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-105185. | |
| FR-62765 | FR-62765, a derivative of WF-3681, is a novel aldose reductase inhibitor. It might be a useful drug for diabetic neuropathy. Uses: Fr-62765 might be a useful drug for diabetic neuropathy. Synonyms: FR 62765; FR-62765; FR62765. 2-Furanpropanoic acid, 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-, ethyl ester;FR62765;2,5-Dihydro-4-methoxy-5-oxo-3-phenylfuran-2-propanoic acid ethyl ester;Ethyl 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-2-furanpropanoate;Ethyl 3-(4-methoxy-5-oxo-3-phenyl-2H-furan-2-yl)propanoate. Grades: >98 %. CAS No. 105346-34-7. Molecular formula: C16H18O5. Mole weight: 290.31. | |
| Govorestat | Govorestat (AT-007) is an orally active brain-penetrant aldose reductase inhibitor with an IC 50 value of 100 pM. Govorestat has the potential for galactose-1-phosphate uridyl transferase deficiency research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AT-007. CAS No. 2170729-29-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-129586. | |
| Isoliquiritigenin | Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM. Group: Inhibitors. Alternative Names: 2',4,4'-Trihydroxy-trans-chalcone. CAS No. 961-29-5. Molecular formula: C15H12O4. Mole weight: 256.25. Appearance: Yellow to orange powder. Purity: 0.98. IUPACName: (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one. Canonical SMILES: C1=CC (=CC=C1C=CC (=O)C2=C (C=C (C=C2)O)O)O. Density: 1.384±0.06 g/cm³. Catalog: ACM961295. |  |
| Isoliquiritigenin | Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC 50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC 50 of 24.7 μM. Uses: Scientific research. Group: Natural products. Alternative Names: GU17; ISL; Isoliquiritigen; SJ000286237. CAS No. 961-29-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-N0102. | |
| Minalrestat | Minalrestat is an aldose reductase inhibitor originated by Wyeth. In Aug 2002, Phase-III for Diabetic retinopathy was discontinued in USA and Europe. Uses: Diabetic retinopathy. Synonyms: Minalrestat, ARI-509; WAY-121509; WAY-ARI-509; WAYARI-509; ARI509; WAY121509; WAYARI-509; WAYARI509; Minalrestat [USAN:INN];2-[(4-bromo-2-fluorophenyl)methyl]-6-fluorospiro[isoquinoline-4,3'-pyrrolidine]-1,2',3,5'-tetrone. Grades: 98%. CAS No. 129688-50-2. Molecular formula: C19H11BrF2N2O4. Mole weight: 449.21. | |
| Mumeose K | Mumeose K is the inhibitor for aldose reductase with an IC 50 of 27 μM. Mumeose K exhibits potential anti-diabetic activity, and can be used in research about diabetes-related complication [1]. Uses: Scientific research. Group: Natural products. CAS No. 2132384-01-9. Pack Sizes: 1 mg. Product ID: HY-N13759. | |
| Native Microorganism Sorbitol Dehydrogenase | Sorbitol dehydrogenase (or SDH) is a cytosolic enzyme. In humans this protein is encoded by the SORD gene. Sorbitol dehydrogenase is an enzyme in carbohydrate metabolism converting sorbitol, the sugar alcohol form of glucose, into fructose. Together with aldose reductase, it provides a way for the body to produce fructose from glucose without using ATP. Sorbitol dehydrogenase uses NAD+ as a cofactor; its reaction is sorbitol + NAD+--> fructose + NADH + H+. A zinc ion is also involved in catalysis. Organs that use it most frequently include the liver and seminal vesicle; it is found in all kinds of organisms from bacteria to humans. A secondary use is the metabolism of d... glucitol dehydrogenase; L-iditol:NAD+ oxidoreductase; NAD+-dependent sorbitol dehydrogenase; NAD+-sorbitol dehydrogenase. Enzyme Commission Number: EC 1.1.1.14. CAS No. 9028-21-1. SDH. Mole weight: ca. 68,000; Subunit molecular weight : ca. 26,000. Appearance: Lyophilized. Storage: Stable at -20 °C for at least one year. Source: Microorganism. Sorbitol Dehydrogenase; SDH; EC 1.1.1.14; 9028-21-1; L-iditol 2-dehydrogenase; polyol dehydrogenase; sorbitol dehydrogenase; L-iditol:NAD+ 5-oxidoreductase; L-iditol (sorbitol) dehydrogenase; glucitol dehydrogenase; L-iditol:NAD+ oxidoreductase; NAD+-dependent sorbitol dehydrogenase; NAD+-sorbitol dehydrogenase. Cat No: NATE-1909. | |
| Native Rat Sorbitol Dehydrogenase | Sorbitol dehydrogenase (or SDH) is a cytosolic enzyme. In humans this protein is encoded by the SORD gene. Sorbitol dehydrogenase is an enzyme in carbohydrate metabolism converting sorbitol, the sugar alcohol form of glucose, into fructose. Together with aldose reductase, it provides a way for the body to produce fructose from glucose without using ATP. Sorbitol dehydrogenase uses NAD+ as a cofactor; its reaction is sorbitol + NAD+--> fructose + NADH + H+. A zinc ion is also involved in catalysis. Organs that use it most frequently include the liver and seminal vesicle; it is found in all kinds of organisms from bacteria to humans. A secondary use is the metabolism of dietar...5-oxidoreductase; L-iditol (sorbitol) dehydrogenase; glucitol dehydrogenase; L-iditol:NAD+ oxidoreductase; NAD+-dependent sorbitol dehydrogenase; NAD+-sorbitol dehydrogenase. Enzyme Commission Number: EC 1.1.1.14. CAS No. 9028-21-1. Purity: Purified. SDH. Activity: Reported in U/mg. Storage: -20°C. Form: Lyophilized. Source: Rat Liver. Species: Rat. Sorbitol Dehydrogenase; SDH; EC 1.1.1.14; 9028-21-1; L-iditol 2-dehydrogenase; polyol dehydrogenase; sorbitol dehydrogenase; L-iditol:NAD+ 5-oxidoreductase; L-iditol (sorbitol) dehydrogenase; glucitol dehydrogenase; L-iditol:NAD+ oxidoreductase; NAD+-dependent sorbitol dehydrogenase; NAD+-sorbitol dehydrogenase. Cat No: NATE-0667. | |
| Native Sheep Sorbitol Dehydrogenase | Sorbitol dehydrogenase is an enzyme in carbohydrate metabolism converting sorbitol, the sugar alcohol form of glucose, into fructose. Together with aldose reductase, it provides a way for the body to produce fructose from glucose without using ATP. Sorbitol dehydrogenase uses NAD+ as a cofactor; its reaction is sorbitol + NAD+--> fructose + NADH + H+. A zinc ion is also involved in catalysis. Organs that use it most frequently include the liver and seminal vesicle; it is found in all kinds of organisms from bacteria to humans. A secondary use is the metabolism of dietary sorbitol, though sorbitol is known not to be absorbed as well in the intestine as its related compounds ...rogenase; glucitol dehydrogenase; L-iditol:NAD+ oxidoreductase; NAD+-dependent sorbitol dehydrogenase; NAD+-sorbitol dehydrogenase; L-iditol 2-dehydrogenase. Enzyme Commission Number: EC 1.1.1.14. CAS No. 9028-21-1. SDH. Activity: > 20 units/mg protein. Storage: -20°C. Form: lyophilized powder; Contains maltose. Source: Sheep liver. Species: Sheep. Sorbitol dehydrogenase; SDH; EC 1.1.1.14; 9028-21-1; polyol dehydrogenase; sorbitol dehydrogenase; L-iditol:NAD+ 5-oxidoreductase; L-iditol (sorbitol) dehydrogenase; glucitol dehydrogenase; L-iditol:NAD+ oxidoreductase; NAD+-dependent sorbitol dehydrogenase; NAD+-sorbitol dehydrogenase; L-iditol 2-dehydrogenase. Cat No: NATE-0668. | |
| Nigerloxin | It is originally isolated from Aspergillus niger CFR-W-105. Nigerloxin inhibited the activity of rat lens aldose reductase (RLAR) and lipid oxidase (LOX-1) with IC50 of 69 μmol/L and 79 μmol/L, respectively. Molecular formula: C13H15NO5. Mole weight: 265.26. | |
| Ponalrestat | Ponalrestatis an aldose reductase inhibitor originator byAstraZeneca. It can block the conversion of glucose to sorbitol. Ponalrestatis shows selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 μM. Phase III for the treatment of diabetes was discontinued. Uses: Diabetes. Synonyms: Ponalrestat, ICI-128436; ICI 128436; ICI128436; MK-538; MK 538; MK538. Brand name: Statil; Statyl. QJ0339; QJ0339; QJ-0339; 2-(3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid. Grades: 98%. CAS No. 72702-95-5. Molecular formula: C17H12BrFN2O3. Mole weight: 391.20. | |
| Raniestat | Raniestat, a highly potent aldose reductase inhibitor currently under phase III clinical trials in the US and Canada, is used to treat diabetic neuropathies. Uses: Enzyme inhibitors. Synonyms: (3R) -2'-[ (4-bromo-2-fluorophenyl) methyl]spiro[pyrrolidine-3, 4'-pyrrolo[1, 2-a]pyrazine]-1', 2, 3', 5-tetroneRanirestatAS-3201; AS 3201; AS3201CHEMBL334830147254-64-6SX-3202RaniestatSX 3030; SX3030SX-3030Ranirestat (JAN/INN)AC1L4BEUUNII-Z26P56GFTVZ26P56GFTVSCHEMBL498993D. CAS No. 147254-64-6. Molecular formula: C17H11BrFN3O4. Mole weight: 420.19. | |
| Salfredin A3 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-53-3. Molecular formula: C18H19NO9. Mole weight: 393.30. | |
| Salfredin A4 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-54-4. Molecular formula: C15H15NO7. Mole weight: 321.28. | |
| Salfredin A7 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-55-5. Molecular formula: C16H17NO7. Mole weight: 335.31. | |
| Salfredin B11 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. Synonyms: 6H-Furo(3,4-g)-1-benzopyran-6-one, 2,8-dihydro-5-hydroxy-2,2-dimethyl-; 2,8-Dihydro-5-hydroxy-2,2-dimethyl-6H-furo(3,4-g)-1-benzopyran-6-one; 9-Hydroxy-6,6-dimethyl-3,6-dihydro-2,5-dioxa-cyclopenta[b]naphthalen-1-one. Grades: 98% by HPLC. CAS No. 165467-63-0. Molecular formula: C13H12O4. Mole weight: 232.23. | |
| Salfredin C1 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-56-6. Molecular formula: C13H11NO6. Mole weight: 277.23. | |
| Salfredin C2 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-57-7. Molecular formula: C15H13NO8. Mole weight: 335.26. | |
| Salfredin C3 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-58-8. Molecular formula: C16H15NO8. Mole weight: 349.29. | |
| Sclerotiorin | Antibiotic. Antibacterial. Weak antagonist of human endothelin receptor A (ETA) and B (ETB). Cholesteryl ester transfer protein (CETP) activity inhibitor. Grb2-Shc binding inhibitor. Potent aldose reductase inhibitor. Potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor. Antioxidant. Free radical scavenger. Antifungal. Group: Biochemicals. Alternative Names: (S-(R*,R*-(E,E)))-Sclerotiorin, 7-(acetyloxy)-5-chloro-3-[(1E,3E,5S)-3,5-dimethyl-1,3-heptadien-1-yl]-7-methyl-6H-2-benzopyran-6,8(7H)-dione. Grades: Highly Purified. CAS No. 549-23-5. Pack Sizes: 500ug, 1mg, 5mg. Molecular Formula: C21H23ClO5, Molecular Weight: 390.9. US Biological Life Sciences. | Worldwide |
| Tolrestat | Tolrestat is an orally active and potent aldose reductase inhibitor with IC50 value of 35 nM. It was approved for the control of certain diabetic complications. It reduces RBC (red blood cells) sorbitol levels in rats. It decreased, in dose-related manner, the RBC sorbitol levels in normal and in streptozotocin diabetic rats. It failed a Phase III trial in the U.S. due to toxicity. It was discontinued by Wyeth in 1997 because of the risk of severe liver toxicity and death. It was sold under the tradename Alredase. Uses: Tolrestat was approved for the control of certain diabetic complications. Synonyms: AY 27773; AY-27773; AY27773; Tolrestat; AY-27,773; AY 27,773; AY27,773; Alredase; Tolrestatum; Lorestat;2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]acetic acid;N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine. Grades: 95%. CAS No. 82964-04-3. Molecular formula: C16H14F3NO3S. Mole weight: 357.35. | |
| WF-2421 | WF-2421 is an aldose reductase inhibitor produced by Humicola grisea. Synonyms: WF 2421. CAS No. 128429-19-6. Molecular formula: C19H20N2O8. Mole weight: 404.4. | |
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