Aldose Reductase Suppliers USA
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Product | Description | |
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Aldose reductase-IN-1 Quick inquiry Where to buy Suppliers range | Aldose reductase-IN-1, an aldose reductase inhibitor, could have potential biological usage in the study of breast cancer. IC50: 28.9 pM. Uses: Aldose reductase-in-1 is an aldose reductase inhibitor that could have potential biological usage in the study of breast cancer. Synonyms: Aldose reductase-IN-1; SCHEMBL359604; CS-5128; HY-18967; AT-001; CS 5128; HY 18967; AT 001; CS5128; HY18967; AT001. Grades: 98%. CAS No. 1355612-71-3. Molecular formula: C17H10F3N5O3S. Mole weight: 421.35. | |
1,2-Dimethyl-hydrazine Dihydrochloride Quick inquiry Where to buy Suppliers range | 1,2-Dimethylhydrazine is a potent carcinogen that acts as a DNA alkylating agent. It is used to induce colon tumors in experimental animals. It was also used in preparation of spiroisoquinolinedione aldose reductase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 306-37-6. Pack Sizes: 2.5g, 5g. Molecular Formula: C2H10Cl2N2, Molecular Weight: 133.02. US Biological Life Sciences. | Worldwide |
1,5-Anhydro-D-galactitol Quick inquiry Where to buy Suppliers range | 1,5-Anhydro-D-galactitol, a versatile biomedicine widely employed in managing complications associated with diabetes and ocular cataracts, exhibits exceptional capacity in inhibiting aldose reductase. This enzymatic inhibition effectively hampers the intracellular accumulation of sorbitol. By curbing sorbitol levels, this remarkable compound substantially alleviates diabetic retinopathy and initiates the amelioration of nerve impairments. Moreover, due to its inherent properties, 1,5-Anhydro-D-galactitol showcases promising prospects as a beneficial supplement to the food and pharmaceutical sectors, augmenting its applicability in a multifaceted manner. CAS No. 3971-48-0. Molecular formula: C6H12O5. Mole weight: 164.16. | |
1-Cyanotetraline Quick inquiry Where to buy Suppliers range | 1-Cyanotetraline is used in the synthesis of aldose reductase inhibitors. Also reductase enzymes are believed to catalyze the formation of sorbitol from glucose leading to the chronic complications of diabetes mellitus. It is also used in the synthesis of baclofen analogs, potent GABAB agonists. Group: Biochemicals. Alternative Names: 1, 2, 3, 4-Tetrahydro-1-naphthalene carbonitrile; 1,2,3,4-Tetrahydro-1-naphthonitrile; 1, 2, 3, 4-Tetrahydro-1-naphthalene carbonitrile; 1-Cyano-1,2,3,4-tetrahydronaphthalene; 1-Cyanotetralin. Grades: Highly Purified. CAS No. 56536-96-0. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
1-Deoxy-1-nitro-L-galactitol Quick inquiry Where to buy Suppliers range | 1-Deoxy-1-nitro-L-galactitol, a remarkable biomedicine marvel, aims to revolutionize the field of diabetes treatment. By diligently impeding the activity of the enzyme aldose reductase, its profound impact on mitigating the genesis of diabetic complications cannot be overstated. Synonyms: 1-Deoxy-1-nitro-L-galactitol; 94481-72-8; (2S,3R,4S,5R)-6-NITROHEXANE-1,2,3,4,5-PENTOL; GEO-04691; J-200016; W-204109; (2S,3R,4S,5R)-6-nitrohexane-1,2,3,4,5-pentaol. CAS No. 94481-72-8. Molecular formula: C6H13NO7. Mole weight: 211.17. | |
1-Deoxy-D-sorbose Quick inquiry Where to buy Suppliers range | 1-Deoxy-D-sorbose, a remarkable biomedical substance, presents itself as a promising therapeutic tool in the management of diabetes. By means of obstructing the action of aldose reductase, a pivotal enzyme implicated in diabetic complications, this compound adeptly modulates blood glucose levels. Synonyms: methylxylose. Molecular formula: C6H12O5. Mole weight: 164.16. | |
20(S)-Ginsenoside Rg2 Quick inquiry Where to buy Suppliers range | 20(S)-Ginsenoside Rg2 is used as an aldose reductase inhibitor and my exert anti-inflammatory and immunomodulatory activity. It exists as a bioactive metabolite of the ginsenoside component of Panax ginseng. Group: Biochemicals. Grades: Highly Purified. CAS No. 52286-74-5. Pack Sizes: 50mg, 500mg. Molecular Formula: C42H72O13. US Biological Life Sciences. | Worldwide |
2-[[1-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid Quick inquiry Where to buy Suppliers range | 2-[[1-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 260784-21-2. Pack Sizes: 100mg, 1g. Molecular Formula: C16H11NO4S2, Molecular Weight: 345.39. US Biological Life Sciences. | Worldwide |
2-[2, 4-dibromo-6-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]phenoxy]-acetic Acid Quick inquiry Where to buy Suppliers range | 2-[2, 4-dibromo-6-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]phenoxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 123021-81-8. Pack Sizes: 50mg, 500mg. Molecular Formula: C12H7Br2NO4S2, Molecular Weight: 453.13. US Biological Life Sciences. | Worldwide |
2-[2, 4-dichloro-6-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]phenoxy]-acetic Acid Quick inquiry Where to buy Suppliers range | 2-[2, 4-dichloro-6-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]phenoxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 123021-78-3. Pack Sizes: 100mg, 1g. Molecular Formula: C12H7Cl2NO4S2, Molecular Weight: 364.22. US Biological Life Sciences. | Worldwide |
2-[[2-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-1-naphthalenyl]oxy]-acetic Acid Quick inquiry Where to buy Suppliers range | 2-[[2-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-1-naphthalenyl]oxy]-acetic Acid is an analog of 2-[[1-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid (O859575). 2-[[1-[ (Z) - (4-Oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 1348775-25-6. Pack Sizes: 25mg, 250mg. Molecular Formula: C16H11NO4S2, Molecular Weight: 345.39. US Biological Life Sciences. | Worldwide |
2,3,4,6-Tetrakis-O-(phenylmethyl)- β-D-glucopyranose 1-[3, 4, 5-Tris (phenylmethoxy) benzoate] Quick inquiry Where to buy Suppliers range | 2,3,4,6-Tetrakis-O-(phenylmethyl)- β-D-glucopyranose 1-[3, 4, 5-Tris (phenylmethoxy) benzoate] is an protected intermediate in the synthesis of β-Glucogallin (G416000), a novel aldose reductase (ALR2) inhibitor, one of the factors regulating the secondary complications arising from diabetes mellitus. Group: Biochemicals. Grades: Highly Purified. CAS No. 1195367-79-3. Pack Sizes: 25mg, 50mg. Molecular Formula: C62H58O10. US Biological Life Sciences. | Worldwide |
2-[[6-Bromo-1-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid Quick inquiry Where to buy Suppliers range | 2-[[6-bromo-1-[ (4-oxo-2-thioxo-5-thiazolidinylidene) methyl]-2-naphthalenyl]oxy]-acetic Acid is used in biological activities in the preparation and aldose reductase inhibitory activity of a new series of 5-[[2- (ω -carboxyalkoxy) aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 123021-42-1. Pack Sizes: 50mg, 500mg. Molecular Formula: C16H10BrNO4S2, Molecular Weight: 424.29. US Biological Life Sciences. | Worldwide |
2,6-Dibromoquinone Quick inquiry Where to buy Suppliers range | 2,6-Dibromoquinone is a reagent used in the preparation of halodiphenyl ether derivatives which has human aldose reductase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 19643-45-9. Pack Sizes: 100mg, 1g. Molecular Formula: C6H2Br2O2. US Biological Life Sciences. | Worldwide |
2-Bromo-5-fluoro-4-methylanisole Quick inquiry Where to buy Suppliers range | 2-Bromo-5-fluoro-4-methylanisole is being used in studies for the design and preparation of (arylcarbamoylphenoxy) acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications. Group: Biochemicals. Grades: Highly Purified. CAS No. 314298-15-2. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H8BrFO, Molecular Weight: 219.05. US Biological Life Sciences. | Worldwide |
2-Chloro-1- (4-fluorobenzyl) benzimidazole Quick inquiry Where to buy Suppliers range | A novel aldose reductase (ALR2) inhibitor. It is used for preparation of disubstituted benzimidazole derivative as anti-allergic agent (Mizolastine). Group: Biochemicals. Grades: Highly Purified. CAS No. 84946-20-3. Pack Sizes: 1g, 10g, 25g. Molecular Formula: C??H??ClFN?. US Biological Life Sciences. | Worldwide |
(2Z)-2-Methyl-3-phenyl-2-propenal Quick inquiry Where to buy Suppliers range | (2Z)-2-Methyl-3-phenyl-2-propenal (Epalrestat Impurity 2) is an impurity of Epalrestat (E565300), an aldose reductase inhibitor used to treat diabetic neuropathy. Group: Biochemicals. Grades: Highly Purified. CAS No. 66051-14-7. Pack Sizes: 100mg, 500mg. Molecular Formula: C10H10O, Molecular Weight: 146.19. US Biological Life Sciences. | Worldwide |
2-((Z)-5-((E)-2-methyl-3-phenylallylidene)-2,4-dioxothiazolidin-3-yl)acetic acid Quick inquiry Where to buy Suppliers range | An impurity of Epalrestat, a carboxylic acid-based inhibitor of aldose reductase. Synonyms: 2-[5-((2E)-2-methyl-3-phenylprop-2-enylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]a cetic acid. CAS No. 794510-29-5. Molecular formula: C15H13NO4S. Mole weight: 303.3. | |
3-(4-Chlorophenyl)-1,2,4-oxadiazole-5-butanoic Acid Quick inquiry Where to buy Suppliers range | An aldose reductase inhibitor. Group: Biochemicals. Alternative Names: 4-[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]butanoic Acid. Grades: Highly Purified. CAS No. 439108-15-3. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
3-Deoxy-3-fluoro-D-galactitol Quick inquiry Where to buy Suppliers range | 3-Deoxy-3-fluoro-D-galactitol is an exceptional biomedical compound, specifically designed to study the complex nature of hereditary galactosemia. Employing its extraordinary competitive inhibitory potential against aldose reductase, this remarkable compound effectively curtails the deleterious buildup of galactitol. Synonyms: 3-Deoxy-3-fluoro-D-glucitol; 3-Deoxy-3-fluoro-D-galactitol; 864720-85-4; 34339-82-7; (2R,3R,4S,5R)-4-Fluorohexane-1,2,3,5,6-pentol; AKOS006271586; (2R,3R,4S,5R)-4-fluorohexane-1,2,3,5,6-pentaol. Molecular formula: C6H13FO5. Mole weight: 184.16. | |
(3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinone Quick inquiry Where to buy Suppliers range | (3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinone is a biomedically relevant substance used in pharmaceutical formulations. It helps in diabetes management by serving as a potent inhibitor of human aldose reductase, a key enzyme involved in pathogenic complications of diabetes. Molecular formula: C5H9NO4. Mole weight: 147.13. | |
5-Methoxyindole-3-acetonitrile-d2 Quick inquiry Where to buy Suppliers range | 5-Methoxyindole-3-acetonitrile-d2 is a labelled analogue of 5-Methoxyindole-3-acetonitrile (M262818), which is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors. 5-Methoxyindole-3-acetonitrile-d2 is also an intermediate in synthesizing Melatonin-d4 (M215002), a hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation / metastasis of breast cancer cells by inhibiting estrogen receptor action. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C11H8D2N2O. US Biological Life Sciences. | Worldwide |
6-Deoxy-L-galactitol Quick inquiry Where to buy Suppliers range | 6-Deoxy-L-galactitol, a sugar alcohol, exhibits promising therapeutic capabilities for the management of diabetic complications. Its ability to manipulate aldose reductase, an enzyme that transfigures glucose to sorbitol impedes the accumulation of sorbitol in cells. Furthermore, studies suggest it could potentially be used as an anti-inflammatory and antioxidant agent. Synonyms: 1-deoxy-d-galactitol; (2R,3S,4R,5S)-hexane-1,2,3,4,5-pentol. CAS No. 13074-06-1. Molecular formula: C6H14O5. Mole weight: 166.17. | |
Alrestatin Quick inquiry Where to buy Suppliers range | Alrestatin is an inhibitor of aldose reductase (IC50 = 148 μM). Uses: Specific inhibitor of aldose reductase. Synonyms: Alrestatine; 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid. Grades: ≥98%. CAS No. 51411-04-2. Molecular formula: C14H9NO4. Mole weight: 255.23. | |
Alrestatin (sodium) Quick inquiry Where to buy Suppliers range | Alrestatin sodium is a specific inhibitor of aldose reductase (IC50 = 148 μM). Uses: A specific inhibitor of aldose reductase. Synonyms: Sodium;2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetate. Grades: ≥98%. CAS No. 51876-97-2. Molecular formula: C14H8NNaO4. Mole weight: 277.21. | |
Asperaldin Quick inquiry Where to buy Suppliers range | Asperaldin is an aldose reductase (ECLLL21) inhibitor produced by Aspergillus niger CFR-1046. Synonyms: 1,4-Naphthalenedione, 8-(hexyloxy)-2,6-dihydroxy-. CAS No. 561297-46-9. Molecular formula: C16H18O5. Mole weight: 290.31. | |
CP-744809 Quick inquiry Where to buy Suppliers range | CP-744809 is a highly selective orally available small molecule inhibitor of aldose reductase. Uses: Aldose reductase inhibitor. Synonyms: CP-744809; CP744809; CP 744809; ARI-809; ARI 809; ARI809; UNII-U63F8E95J1. 6-((5-chloro-3-methyl-2-benzofuranyl)sulfonyl)-3(2H)-Pyridazinone. Grades: ≥98%. CAS No. 463976-07-0. Molecular formula: C13H9ClN2O4S. Mole weight: 324.74. | |
EBPC Quick inquiry Where to buy Suppliers range | EBPC is a potent and selective aldose reductase inhibitor. It is used to improve the cytotoxicity of anticancer reagents such as cisplatin and doxorubicin in HeLa cervical carcinoma cells via an increase in ERK activity. Synonyms: Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate; 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester; MFCD00179167; 1-benzyl-4-[ethoxy (hydroxy)methylidene]pyrrolidine-2, 3-dione. Grades: ≥99% by HPLC. CAS No. 4450-98-0. Molecular formula: C14H15NO4. Mole weight: 261.28. | |
EBPC Quick inquiry Where to buy Suppliers range | A highly specific aldose reductase inhibitor that has been shown to enhance HeLa cell sensitivity to chemotherapeutic drugs. Group: Biochemicals. Alternative Names: 2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester; 1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester; NSC 229530; CP-10668. Grades: Highly Purified. CAS No. 4450-98-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Epalrestat Quick inquiry Where to buy Suppliers range | Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM. Uses: Enzyme inhibitors. Synonyms: Epalrestat; Kinedak; ONO-2235; ONO 2235; ONO2235; Sorbistat. Grades: >98%. CAS No. 82159-09-9. Molecular formula: C15H13NO3S2. Mole weight: 319.4. | |
Epalrestat Quick inquiry Where to buy Suppliers range | An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy. Group: Biochemicals. Alternative Names: (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic Acid. Grades: Highly Purified. CAS No. 82159-09-9. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
Epalrestat Dimer Quick inquiry Where to buy Suppliers range | Dimer impurity of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: Dimer of 5Z-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. Grades: > 95%. Molecular formula: C30H26N2O6S4. Mole weight: 638.81. | |
Epalrestat (E, E)-Isomer Quick inquiry Where to buy Suppliers range | A stereoisomer of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: 2-((Z)-5-((Z)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid. Grades: > 95%. Molecular formula: C15H13NO3S2. Mole weight: 319.40. | |
Epalrestat (E, Z)-Isomer Quick inquiry Where to buy Suppliers range | A stereoisomer of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: (E,Z)-5-(2-Methyl-3-phenyl-2-propen-1-ylidene)-4-oxo-2-thioxo-3-thiazolidineacetic Acid. Grades: > 95%. Molecular formula: C15H13NO3S2. Mole weight: 319.40. | |
Epalrestat (Z, Z)-Isomer Quick inquiry Where to buy Suppliers range | A stereoisomer of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: 2-((Z)-5-((Z)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid. Grades: > 95%. Molecular formula: C15H13NO3S2. Mole weight: 319.40. | |
Fidarestat Quick inquiry Where to buy Suppliers range | Fidarestat is a aldose reductase inhibitor originated by Sanwa Kagaku Kenkyusho. It was very effective in significantly alleviating some symptoms of diabetic polyneuropathy. Long-term treatment with SNK-860 has a beneficial preventive effect on the development of experimental diabetic neuropathy. In addition, Fidarestat is also a promising drug targeting autophagy in Colorectal Carcinoma. Uses: Diabetic neuropathies. Synonyms: SNK860; SNK-860; SNK 860; SK860; SK-860; SK 860; Fidarestat; Aldos. (2S,4S)-6-fluoro-2',5'-dioxospiro[chromane-4,4'-imidazolidine]-2-carboxamide; Aldos;SNK 860. Grades: 98%. CAS No. 136087-85-9. Molecular formula: C12H10FN3O4. Mole weight: 279.23. | |
FR-62765 Quick inquiry Where to buy Suppliers range | FR-62765, a derivative of WF-3681, is a novel aldose reductase inhibitor. It might be a useful drug for diabetic neuropathy. Uses: Fr-62765 might be a useful drug for diabetic neuropathy. Synonyms: FR 62765; FR-62765; FR62765. 2-Furanpropanoic acid, 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-, ethyl ester;FR62765;2,5-Dihydro-4-methoxy-5-oxo-3-phenylfuran-2-propanoic acid ethyl ester;Ethyl 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-2-furanpropanoate;Ethyl 3-(4-methoxy-5-oxo-3-phenyl-2H-furan-2-yl)propanoate. Grades: >98 %. CAS No. 105346-34-7. Molecular formula: C16H18O5. Mole weight: 290.31. | |
Minalrestat Quick inquiry Where to buy Suppliers range | Minalrestat is an aldose reductase inhibitor originated by Wyeth. In Aug 2002, Phase-III for Diabetic retinopathy was discontinued in USA and Europe. Uses: Diabetic retinopathy. Synonyms: Minalrestat, ARI-509; WAY-121509; WAY-ARI-509; WAYARI-509; ARI509; WAY121509; WAYARI-509; WAYARI509; Minalrestat [USAN:INN];2-[(4-bromo-2-fluorophenyl)methyl]-6-fluorospiro[isoquinoline-4,3'-pyrrolidine]-1,2',3,5'-tetrone. Grades: 98%. CAS No. 129688-50-2. Molecular formula: C19H11BrF2N2O4. Mole weight: 449.21. | |
Nigerloxin Quick inquiry Where to buy Suppliers range | It is originally isolated from Aspergillus niger CFR-W-105. Nigerloxin inhibited the activity of rat lens aldose reductase (RLAR) and lipid oxidase (LOX-1) with IC50 of 69 μmol/L and 79 μmol/L, respectively. Molecular formula: C13H15NO5. Mole weight: 265.26. | |
Ponalrestat Quick inquiry Where to buy Suppliers range | Ponalrestatis an aldose reductase inhibitor originator byAstraZeneca. It can block the conversion of glucose to sorbitol. Ponalrestatis shows selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 μM. Phase III for the treatment of diabetes was discontinued. Uses: Diabetes. Synonyms: Ponalrestat, ICI-128436; ICI 128436; ICI128436; MK-538; MK 538; MK538. Brand name: Statil; Statyl. QJ0339; QJ0339; QJ-0339; 2-(3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid. Grades: 98%. CAS No. 72702-95-5. Molecular formula: C17H12BrFN2O3. Mole weight: 391.20. | |
Raniestat Quick inquiry Where to buy Suppliers range | Raniestat, a highly potent aldose reductase inhibitor currently under phase III clinical trials in the US and Canada, is used to treat diabetic neuropathies. Uses: Enzyme inhibitors. Synonyms: (3R) -2'-[ (4-bromo-2-fluorophenyl) methyl]spiro[pyrrolidine-3, 4'-pyrrolo[1, 2-a]pyrazine]-1', 2, 3', 5-tetroneRanirestatAS-3201; AS 3201; AS3201CHEMBL334830147254-64-6SX-3202RaniestatSX 3030; SX3030SX-3030Ranirestat (JAN/INN)AC1L4BEUUNII-Z26P56GFTVZ26P56GFTVSCHEMBL498993D. CAS No. 147254-64-6. Molecular formula: C17H11BrFN3O4. Mole weight: 420.19. | |
Salfredin A3 Quick inquiry Where to buy Suppliers range | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-53-3. Molecular formula: C18H19NO9. Mole weight: 393.30. | |
Salfredin A4 Quick inquiry Where to buy Suppliers range | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-54-4. Molecular formula: C15H15NO7. Mole weight: 321.28. | |
Salfredin A7 Quick inquiry Where to buy Suppliers range | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-55-5. Molecular formula: C16H17NO7. Mole weight: 335.31. | |
Salfredin B11 Quick inquiry Where to buy Suppliers range | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. Synonyms: 6H-Furo(3,4-g)-1-benzopyran-6-one, 2,8-dihydro-5-hydroxy-2,2-dimethyl-; 2,8-Dihydro-5-hydroxy-2,2-dimethyl-6H-furo(3,4-g)-1-benzopyran-6-one; 9-Hydroxy-6,6-dimethyl-3,6-dihydro-2,5-dioxa-cyclopenta[b]naphthalen-1-one. Grades: 98% by HPLC. CAS No. 165467-63-0. Molecular formula: C13H12O4. Mole weight: 232.23. | |
Salfredin C1 Quick inquiry Where to buy Suppliers range | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-56-6. Molecular formula: C13H11NO6. Mole weight: 277.23. | |
Salfredin C2 Quick inquiry Where to buy Suppliers range | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-57-7. Molecular formula: C15H13NO8. Mole weight: 335.26. | |
Salfredin C3 Quick inquiry Where to buy Suppliers range | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-58-8. Molecular formula: C16H15NO8. Mole weight: 349.29. | |
Sclerotiorin Quick inquiry Where to buy Suppliers range | Antibiotic. Antibacterial. Weak antagonist of human endothelin receptor A (ETA) and B (ETB). Cholesteryl ester transfer protein (CETP) activity inhibitor. Grb2-Shc binding inhibitor. Potent aldose reductase inhibitor. Potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor. Antioxidant. Free radical scavenger. Antifungal. Group: Biochemicals. Alternative Names: (S-(R*,R*-(E,E)))-Sclerotiorin, 7-(acetyloxy)-5-chloro-3-[(1E,3E,5S)-3,5-dimethyl-1,3-heptadien-1-yl]-7-methyl-6H-2-benzopyran-6,8(7H)-dione. Grades: Highly Purified. CAS No. 549-23-5. Pack Sizes: 500ug, 1mg, 5mg. Molecular Formula: C21H23ClO5, Molecular Weight: 390.9. US Biological Life Sciences. | Worldwide |
Tolrestat Quick inquiry Where to buy Suppliers range | Tolrestat is an orally active and potent aldose reductase inhibitor with IC50 value of 35 nM. It was approved for the control of certain diabetic complications. It reduces RBC (red blood cells) sorbitol levels in rats. It decreased, in dose-related manner, the RBC sorbitol levels in normal and in streptozotocin diabetic rats. It failed a Phase III trial in the U.S. due to toxicity. It was discontinued by Wyeth in 1997 because of the risk of severe liver toxicity and death. It was sold under the tradename Alredase. Uses: Tolrestat was approved for the control of certain diabetic complications. Synonyms: AY 27773; AY-27773; AY27773; Tolrestat; AY-27,773; AY 27,773; AY27,773; Alredase; Tolrestatum; Lorestat;2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]acetic acid;N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine. Grades: 95%. CAS No. 82964-04-3. Molecular formula: C16H14F3NO3S. Mole weight: 357.35. | |
WF-2421 Quick inquiry Where to buy Suppliers range | WF-2421 is an aldose reductase inhibitor produced by Humicola grisea. Synonyms: WF 2421. CAS No. 128429-19-6. Molecular formula: C19H20N2O8. Mole weight: 404.4. | |
WF-3681 Quick inquiry Where to buy Suppliers range | WF-3681 is an aldose reductase inhibitor produced by Chaetomella raphigera Swift No. 3681. Synonyms: WF 3681. CAS No. 105364-56-5. Molecular formula: C13H12O5. Mole weight: 248.23. | |
YUA001 Quick inquiry Where to buy Suppliers range | YUA001 is an aldose reductase inhibitor produced from alkalophilic Corynebacterium sp. YUA25. It has no antimicrobial activity. Synonyms: YUA-001. Molecular formula: C13H19NO2. Mole weight: 221.29. | |
Zenarestat Quick inquiry Where to buy Suppliers range | Zenarestat is an aldose reductase inhibitor. It was investigated as a treatment of diabetic neuropathy and cataract. It was developed by Fujisawa Pharmaceutical Co Ltd and was terminated in clinic phase 3 trials. Uses: Zenarestat was investigated as a treatment of diabetic neuropathy and cataract. Synonyms: FR 74366; FR74366 FR-74366; CI-1014; FK-366; CI1014; FK366; FK 366; FK-366; Zenarestat;2-[3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4-dioxoquinazolin-1-yl]acetic acid;FR74366;3-(2-Fluoro-4-bromobenzyl)-7-chloro-2,4(1H,3H)-dioxoquinazoline-1-acetic acid;3-[(4-Bromo-2-fluorophenyl)methyl]-7-chloro-3,4-dihydro-2,4-dioxo-1(2H)-quinazolineacetic acid. Grades: 95%. CAS No. 112733-06-9. Molecular formula: C17H11BrClFN2O4. Mole weight: 441.64. | |
Zopolrestat Quick inquiry Where to buy Suppliers range | Zopolrestat is an inhibitor of Aldose Reductase(AR). It has been shown to play roles in inflammation and cancer. It is used for the treatment of diabetic nephropathy and cardiac disease. It was developed by Pfizer and was terminated in clinic phase 2 trials. Uses: Zopolrestat is used for the treatment of diabetic nephropathy and cardiac disease. Synonyms: 3-[(5-Trifluoromethyl-2-benzothiazolyl)methyl]-3,4-dihydro-4-oxophthalazine-1-acetic acid;CP-73850;3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1-phthalazineacetic acid;Alond;Xedia;2-[4-Oxo-3-[[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl]phthalazin-1-yl]acetic acid;CP 73850; CP73850; CP-73850; Zopolrestat; Zopolrestatum. Grades: 95%. CAS No. 110703-94-1. Molecular formula: C19H12F3N3O3S. Mole weight: 419.38. |