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| Product | Description | |
|---|---|---|
| Amyl Formate | Amyl Formate (Normal). CAS No. 638-49-3. FEMA No. 2068. Kosher: Y. VIGON Item # 501794. Categories: Speciality Ingredients Suppliers, Flavors, Fragrances, Perfumers. |  America & Internationally |
| Amyl Formate FCC | Amyl Formate FCC (Mixed Isomers 35/65). CAS No. ISOMER MIXTURE. Kosher: Y. VIGON Item # 500515. Categories: Speciality Ingredients Suppliers, Flavors, Fragrances, Perfumers. | America & Internationally |
| 2,4-O-Benzylidene-1-O-tosyl-D-threitol | 2,4-O-Benzylidene-1-O-tosyl-D-threitol, a chemical entity, finds application in the realm of neurodegenerative disorders, such as Alzheimer's and Parkinson's. It manifests its potential through inhibition of certain enzymes, catalyzing beta-amyloid plaque formation, which is known to augment disease pathogenesis. This compound, hence, displays prospective therapeutic benefits in the management of aforementioned neurological maladies. |  |
| 2-O-α-L-Fucopyranosyl-D-galactose | 2-O-α-L-Fucopyranosyl-D-galactose is a compound used in the research of neurodegenerative disorders, such as Alzheimer's disease, by inhibiting the formation of beta-amyloid plaques. Uses: A new type of β-propeller architecture formed by oligomerization and interacting with fucoside, fucosyllactose, and plant xyloglucan. Synonyms: 2-O-(6-Deoxy-α-L-galactopyranosyl)-D-galactose; Blood Group H Disaccharide; Fuc1-α-2Gal. Grades: 97%. CAS No. 24656-24-4. Molecular formula: C12H22O10. Mole weight: 326.3. | |
| 3-Aminobenzoic-d4 Acid | A chemoattractants against Pseudomonas strains. A reactant used in the preparation of influenza neuraminidase inhibitors, inhibitors of transthyretin amyloid fibril formation and Iihibitors of the protein chaperone Hsp90. Group: Biochemicals. Alternative Names: 3-Aminobenzenecarboxylic Acid; 3-Carboxyaniline; Aniline-3-carboxylic Acid; NSC 15012; m-Aminobenzoic Acid; m-Anthranilic Acid; m-Carboxyaniline; m-Carboxyphenylamine. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| 5-TAMRA-Amyloid β-Protein (1-40) | Anderson and Webb were able to verify by transmission electron microscopy that the N-terminal labeling of Aβ40 with TAMRA and other fluorescent dyes could not prevent the formation of protofibrils and amyloid fibrils of various widths. Synonyms: 5-TAMRA-Aβ40; 5-TAMRA-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH. Grades: ≥95%. CAS No. 1802087-81-5. Molecular formula: C219H315N55O62S. Mole weight: 4742.31. | |
| Acid Brown 314 | C.I. Acid Brown 314 is a synthetic dye that belongs to the azo group of dyes. It is commonly used in the textile industry to dye cotton, wool, and silk. However, in recent years, C.I. Acid Brown 314 has gained attention in the scientific community due to its potential applications in various fields. Uses: C.i. acid brown 314 has been extensively studied for its potential applications in various fields. in the field of biomedicine, it has been shown to have anticancer properties by inhibiting the growth of cancer cells. in addition, it has been studied for its potential use as an antimicrobial agent, as it has been shown to inhibit the growth of various bacteria and fungi. furthermore, c.i. acid brown 314 has been studied for its potential use in the treatment of alzheimer's disease, as it has been shown to inhibit the formation of beta-amyloid fibrils. Group: Heterocyclic organic compound. Alternative Names: C.I. Acid Brown 314;Acid brown 314;Acid Fast Brown HG;Formo Acid Brown NCF;Formo Brown NCF;Sella Fast Brown HG;Vilmacor Fast Brown HG. CAS No. 12219-81-7. Appearance: brown powder. Purity: 0.99. Catalog: ACM12219817. |  |
| Adamantoic Acid | Adamantoic Acid is an inhibitor of chorismate mutase activity and hydroxyphenylpyruvate synthase. It inhibits TTR conformational changes facilitating amyloid fibril formation. Group: Biochemicals. Alternative Names: 1-Adamantanecarboxylic Acid; 1-Adamantane-1-carboxylic Acid; 1-Adamantylcarboxylic Acid; 1-Carboxyadamantane; NSC 94182; Tricyclo[3.3.1.13, 7]decane-1-carboxylic Acid. Grades: Highly Purified. CAS No. 828-51-3. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| α amylase enzyme for flour | A fungal alpha amylase enzyme preparation produced by a selected strain of Aspergillus species. Applications: It is specialty used as an ingredient in flour improvement, when flour itself has a low content of alpha amylase. flourfaa ensures continuous formation of dextrins and maltose from available starch of flour and enhanced quality of flour. Group: Enzymes. Synonyms: Alpha amylase enzyme; for flour; fungal alpha amylase enzyme; enhance quality of flour enzyme; enhance quality; alpha amylase enzyme; flour; alpha amylase; Alpha amylase enzyme for flour; FLO-1301. CAS No. 9000-90-2. α-Amylase. Appearance: powder or liquid. Source: Aspergillus species. Alpha amylase enzyme; for flour; fungal alpha amylase enzyme; enhance quality of flour enzyme; enhance quality; alpha amylase enzyme; flour; alpha amylase; Alpha amylase enzyme for flour; FLO-1301. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form) or subject to client requirement. Cat No: FLO-1301. |  |
| ALZ-801 | ALZ-801 is a novel and orally available prodrug of tramiprosate that is undergoing a clinical trial for the treatment of Alzheimer's disease (AD). Compared to tramiprosate, ALZ-801 improves some critical properties including tolerability, pharmacokinetic and pharmacodynamic profile, as well as metabolic stability. It inhibits the toxic amyloid oligomers formation associated with AD, which is a discovery of new mechanism of AD prevention. Uses: Prevention of alzheimer's disease (ad). Synonyms: ALZ-801; ALZ 801; ALZ801. | |
| Amylin (14-20) (human) | The formation of amyloid deposits by IAPP can play a central role in the pathogenesis of type 2 diabetes. In addition to the amyloidogenic 20-29 region, the NFLVHSS domain (IAPP 14-20) tends to aggregate and seems to be involved in plaque formation. Synonyms: H-Asn-Phe-Leu-Val-His-Ser-Ser-OH; L-asparagyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-serine; (2S,5S,8S,11S,14S,17S,20S)-8-((1H-imidazol-4-yl)methyl)-20,22-diamino-17-benzyl-2,5-bis(hydroxymethyl)-14-isobutyl-11-isopropyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18-hexaazadocosan-1-oic acid. Grades: ≥95%. CAS No. 121341-77-3. Molecular formula: C36H54N10O11. Mole weight: 802.89. | |
| BACE-1 Inhibitor | BACE-1 Inhibitor is a potent, selective and cell-permeable inhibitor of human β-secretase (BACE-1) binding to the active site of BACE-1. It inhibits secretion of amyloid-β (Aβ) precursor protein (APP; IC50 = 29 nM) in HEK293T cells and also suppresses formation of the Aβ peptides Aβ38, Aβ40, and Aβ42 in primary chick neurons (IC50s = 3.7, 4.7, and 4.8 nM, respectively). Synonyms: BACE-1 Inhibitor; BACE 1 Inhibitor; BACE1 Inhibitor; Beta-Secretase Inhibitor IV; β-Secretase Inhibitor IV; N1-[(1S,2R)-3-(Cyclopropylamino)-2-hydroxy-1-(phenylmethyl)propyl]-5-[methyl(methylsulfonyl)amino]-N3-[(1R)-1-phenylethyl]-1,3-benzenedicarboxamide; Axon 1125. Grades: 98%. CAS No. 797035-11-1. Molecular formula: C31H38N4O5S. Mole weight: 578.72. | |
| β-Amyloid (1-40) | Amyloid β-Peptide (1-40) (human) is a 40-residue protein fragment of the C-terminal portion of the β-amyloid protein, which is found in plaques in the brains of patients with Alzheimer's disease. It is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. It prevented neuronal cell death by inhibiting fibril formation when administered concurrently with Aβ (1-42) in rat cortical cultures at 3 μM. It prevented neuronal damage when injected into rat entorhinal cortex with Aβ (1-42) both at 400 μM. Synonyms: Amyloid β Protein Fragment 1-40; Aβ40. Grades: 95%. CAS No. 131438-79-4. Molecular formula: C194H295N53O58S. Mole weight: 4329.8599999999997. | |
| Beta-Sheet Breaker Peptide iAβ5 | Beta-Sheet Breaker Peptide iAβ5 inhibits amyloid formation in rat brain models. Synonyms: L-Aspartic acid, L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-; L-Aspartic acid, N-[N-[N-(1-L-leucyl-L-prolyl)-L-phenylalanyl]-L-phenylalanyl]-; L-Leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-aspartic acid; FibIII; Fibrillogenesis inhibitor III; IAβ5; H-Leu-Pro-Phe-Phe-Asp-OH; LPFFD. Grades: ≥95%. CAS No. 182912-74-9. Molecular formula: C33H43N5O8. Mole weight: 637.72. | |
| Beta-Sheet Breaker Peptide iAβ5 acetate | Beta-Sheet Breaker Peptide iAβ5 acetate inhibits amyloid formation in rat brain models. Synonyms: Beta-Sheet Breaker Peptide iA(c)micro5 Acetate; H-Leu-Pro-Phe-Phe-Asp-OH.CH3CO2H; L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-aspartic acid acetic acid; LPFFD.CH3CO2H; Acetic acid, compd. with (L-leucyl-yl-L-phenylalanyl-yl-L-prolyl-yl-L-phenylalanyl-yl)-L-Aspartate (1:1). Grades: ≥95%. CAS No. 2763585-09-5. Molecular formula: C35H47N5O10. Mole weight: 697.78. | |
| bis(7)-Tacrine | Acetylcholinesterase (AChE) is the primary cholinesterase in the body. It is an enzyme catalyzing the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. Tacrine is an amino acridine compound that inhibits acetylcholinesterase (AChE), which has been proposed as a clinical treatment for Alzheimer's disease. Bis(7)-Tacrine is a tacrine dimer, linked via a 7-carbon alkyl spacer. It inhibits AChE with an IC50 of 0.40 nM, making it more than 1,000 times more potent than tacrine. It is thought to have multiple mechanisms of action including inhibition of AChE, and inihbititon of the amyloid precursor protein/beta-amyloid cascade. It has been shown to inhibit the formation of Aβ1-42 oligomers and reduce the amount of pre-formed Aβ1-42 oligomers. Synonyms: 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydro-acridine. Grades: ≥98%. CAS No. 224445-12-9. Molecular formula: C33H40N4·2HCl. Mole weight: 565.6. | |
| Calcitonin (salmon) | Calcitonin salmon, a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption. Uses: Scientific research. Group: Peptides. Alternative Names: Salmon calcitonin. CAS No. 47931-85-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0090. |  |
| Cathepsin D from Human, recombinant | Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer's plaques. Cathepsin D is produced initially as a pre-pro-enzyme which gets transported to lysosomes via endosomes in most cell types. In endosomes, it gets proteolyzed by unidentified proteases by removal of the pro-peptide to generate...e cathepsins B and L generates mature, active double-chain Cathepsin D. Group: Enzymes. Synonyms: CTSD; 9025-26-7; EC 3.4.23.5; CLN10; CPSD; HEL-S-130P; Procathepsin D. Enzyme Commission Number: EC 3.4.23.5. CAS No. 9025-26-7. Purity: > 80% by SDS-PAGE. CTSD. Mole weight: 45.1 kDa. Activity: >100 pmol/min/mg. Storage: Store at -20°C. Stable for at least 6 months as supplied. Reconstitute to 1 mg/ml in sterile water, store at -80°C in aliquots and use within 6 months after reconstitution. Avoid repeated freeze-thaw cycles. Form: Freeze-Dried. Source: E. coli. Species: Human. CTSD; cathepsin D; 9025-26-7; EC 3.4.23.5; CLN10; CPSD; HEL-S-130P; Procathepsin D. Cat No: NATE-1707. | |
| CGP 52411 | CGP 52411, also called DAPH, inhibits and reverses the formation of Aβ42 fibers (β-sheet content of aggregated β-amyloid (1-42): IC50 = 4.5 μM) in neurons associated with Alzheimer's disease. And it is also a selective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μM in vitro). Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: CGP 52411; CGP52411; CGP-52411; 5,6-dianilinoisoindole-1,3-dione; 406-050-3; Z13D008FZ2; 4,5-dianilinophthalimide; DAPH; Cgp 52411; 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione; 145915-58-8; Cgp-52411; UNII-Z13D008FZ2; CHEMBL268868; 5,6-dianilino-1h-isoindole-1,3(2h)-dione; CHEBI:53110; Z13D008FZ2; AC1Q6JME; DAPH-1; SCHEMBL11017; 4,5-Bis(anilino)phthalimide; D3943_SIGMA; 4,5-bis-(anilino)phthalimide; AC1L1C19; ZINC6094; DTXSID4040393; CTK8D4606; AAALVYBICLMAMA-UHFFFAOYSA-N; BCPP000288; HMS3260P13; 5,6-dianilinoisoindole-1,3-dione; Tox21_500236; ABP000886; AR-1G6110; BDBM50040929; MFCD00236442; AKOS024457581; BCP9000511; CCG-221540; LP00236; CGP 52411/CGP52411; NCGC00093700-01; NCGC00093700-02; NCGC00093700-03; NCGC00093700-04; NCGC00093700-05; NCGC00260921-01; AK393267; HE062397; HE312151; 5,6-Bis-phenylamino-isoindole-1,3-dione; 5,6-Bis(phenylamino)isoindoline-1,3-dione; J587.895K; 1H-Isoindole-1,3(2H)-dione, 5,6-bis(phenylamino)-; BRD-K13087974-001-01-7; CGP 52411|DAPH|5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione. CAS No. 145915-58-8. Molecular formula: C20H15N3O2. Mole weight: 329.35. | |
| CR8 | CR8 is a potent and selective inhibitor of CDK. CR8 is a more potent pyridyl analogue of roscovitine. In comparison to roscovirtine, the compound gains in potency toward CK1, which is involved in amyloid-β formation. The R-CR8 enantiomer is slightly more potent than S. CR8 is around 30 times more potent at cellular assay then roscovitine. (R)?-CR8 induces apoptosis and has neuroprotective effect. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K. Synonyms: (R)-CR8; CR 8; CR-8. Grades: 98%. CAS No. 294646-77-8. Molecular formula: C24H29N7O. Mole weight: 431.544. | |
| Cyclodextrin Glucanotransferase (Crude Enzyme) | In enzymology, a cyclomaltodextrin glucanotransferase is an enzyme that catalyzes the chemical reaction of cyclizing part of a 1,4-alpha-D-glucan molecule through the formation of a 1,4-alpha-D-glucosidic bond. This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. This product with the indicated enzyme activity was briefly purified from engineered E. coli. Applications: Industry; synthesis; nutrition; pharmacology. Group: Enzymes. Synonyms: Bacillus macerans amylase; cyclodextrin glucanotransfera. Enzyme Commission Number: EC 2.4.1.19. CAS No. 9030-9-5. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. Bacillus macerans amylase; cyclodextrin glucanotransferase; α-cyclodextrin glucanotransferase; α-cyclodextrin glycosyltransferase; β-cyclodextrin glucanotransferase; β-cyclodextrin glycosyltransferase; γ-cyclodextrin glycosyltransferase; cyclodextrin glycosyltransferase; cyclomaltodextrin glucotransferase; cyclomaltodextrin glycosyltransferase; konchizaimu; α-1,4-glucan 4-glycosyltransferase, cyclizing; BMA; CGTase; neutral-cyclodextrin glycosyltransferase; 1,4-α-D-glucan 4-α-D-(1,4-α-D-glucano)-transferase (cyclizing). Pack: 100ml. Cat No: NATE-1812. | |
| (Cys0)-Amyloid β-Protein (1-40) | (Cys0)-Amyloid β-Protein (1-40) can be easily and selectively modified, labelled, and coupled to vectors, e.g. by maleimide chemistry, without affecting the sequence involved in fiber formation. The free mercapto moiety of the peptide is attached to the gold surface. Synonyms: H-Cys-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH; L-cysteinyl-L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valine; Cys-Aβ (1-40). Grades: ≥90%. CAS No. 208266-35-7. Molecular formula: C197H300N54O59S2. Mole weight: 4433.01. | |
| DC-Chol hydrochloride | DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 ( IL-2 and IFN-γ ) and Th2 ( IL-5 ) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: DC-Cholesterol hydrochloride. CAS No. 166023-21-8. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-137131. | |
| Emrusolmin | Emrusolmin (Anle138b), an oligomeric aggregation inhibitor, blocks the formation of pathological aggregates of prion protein (PrPSc) and of α-synuclein (α-syn). Emrusolmin strongly inhibits oligomer accumulation, neuronal degeneration, and disease progression in vivo. Emrusolmin has low toxicity and an excellent oral bioavailability and blood-brain-barrier penetration. Emrusolmin blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Anle138b. CAS No. 882697-00-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101855. | |
| EUK 134 | EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril. Synonyms: Acetorphan; EUK-134; EUK134. Grades: >98%. CAS No. 81065-76-1. Molecular formula: C18H18ClMnN2O4. Mole weight: 416.74. | |
| Evomonoside | Evomonoside is a potent natural compound used for studying neurological diseases such as Alzheimer's and Parkinson's. Derived from natural sources, Evomonoside exhibits neuroprotective properties by preventing the formation of amyloid plaques in the brain. Synonyms: (3b,5b)-3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-14-hydroxycard-20(22)-enolide; Digitoxigenin 3-rhamnoside; Digitoxigenin rhamnoside. CAS No. 508-93-0. Molecular formula: C29H44O8. Mole weight: 520.65. | |
| EVP-0015962 | EVP-0015962 is a selective Amyloid precursor protein secretase modulator under the development of FORUM Pharmaceuticals. Chronic treatment with EVP-0015962 can lower the production of Aβ42, attenuate memory deficits, and reduce Aβ plaque formation and inflammation in Tg2576 transgenic animals. EVP-0015962 shows a therapeutic alternative for disease modification in Alzheimer's disease. In Jun 2016, Phase-II for Alzheimer's disease in USA was discontinued. Uses: Alzheimer's disease. Synonyms: EVP-0015962; EVP 0015962; EVP0015962. SCHEMBL3660255; ZSERTYLZGRJLOO-UHFFFAOYSA-N; 2-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)-3-cyclobutylpropanoic acid. Grades: 98%. CAS No. 1447811-26-8. Molecular formula: C22H19ClF6O3. Mole weight: 480.83. | |
| exo-(1?4)-α-D-glucan lyase | The enzyme catalyses the sequential degradation of (1?4)-α-D-glucans from the non-reducing end with the release of 1,5-anhydro-D-fructose. Thus, for an α-glucan containing n (1?4)-linked glucose units, the final products are 1 glucose plus (n-1) 1,5-anhydro-D-fructose. Maltose, maltosaccharides and amylose are all completely degraded. It does not degrade (1?6)-α-glucosidic bonds and thus the degradation of a branched glucan, such as amylopectin or glycogen, will result in the formation of 1,5-anhydro-D-fructose plus a limit dextrin. Other enzymes involved in the anhydrofructose pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.1.111 (1,5-anhydro-D-fructose dehydratase) and EC 5.3.2.7 (ascopyrone tautomerase). Group: Enzymes. Synonyms: α-(1?4)-glucan 1,5-anhydro-D-fructose eliminase; α-1,4-glucan exo-lyase; α-1,4-glucan lyase; GLase. Enzyme Commission Number: EC 4.2.2.13. CAS No. 148710-18-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5088; exo-(1?4)-α-D-glucan lyase; EC 4.2.2.13; 148710-18-3; α-(1?4)-glucan 1,5-anhydro-D-fructose eliminase; α-1,4-glucan exo-lyase; α-1,4-glucan lyase; GLase. Cat No: EXWM-5088. | |
| (Gly22)-Amyloid β-Protein (1-40) | (Gly22)-Amyloid β-Protein (1-40) is a highly neurotoxic Aβ arctic mutant (E22G) that has been used to study the mechanism underlying of soluble and insoluble β-amyloid aggregation formation. As wild-type Aβ, it preferably assembles in the presence of GM1 ganglioside. Synonyms: Amyloid β-Protein (1-40) E22G; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gly-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH; L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-glycyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valine. Grades: ≥95%. CAS No. 175010-18-1. Molecular formula: C191H291N53O56S. Mole weight: 4257.74. | |
| (Met(O)35)-Amyloid β-Protein (1-42) | Compared with Aβ 1-42, (Met(O)35)-Amyloid β-Protein (1-42) is nontoxic to hippocampal neuronal cultures of 9-11 day-old rat embryos and does not produce any protein oxidation. It is also proved that fibril formation is not affected by Met(O)35. Synonyms: Amyloid β-Protein (1-42) sulfoxide; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met(O)-Val-Gly-Gly-Val-Val-Ile-Ala-OH. Grades: ≥95% by HPLC. CAS No. 1802086-68-5. Molecular formula: C203H311N55O61S. Mole weight: 4530.03. | |
| Native Bacillus amyloliquefaciens Protease | Bacterial protease produced by submerged fermentation of a selected strain of Bacillus amyloliquefaciens. Secretion of protease by Bacillus amyloliquefaciens can be inhibited by treatment with the fatty acid synthetase inhibitor cerulenin. Bacterial protease produced by submerged fermentation of a selected strain of bacillus amyloliquefaciens. secretion of protease by bacillus amyloliquefaciens can be inhibited by treatment with the fatty acid synthetase inhibitor cerulenin. Applications: Protease from bacillus amyloliquefaciens has been used for the unhairing of hides and skins. it has also been used in a study to investigate peptide bond formation using the carbamoylmethyl ester as the acyl donor. Group: Enzymes. Synonyms: Protease; Neutrase. CAS No. 9001-92-7. Protease. Form: liquid, > 0.8 U/g. Source: Bacillus amyloliquefaciens. Protease; Neutrase. Cat No: NATE-0632. | |
| Native Bacterial Environmental DNA Glucan elongation enzyme | A thermostable 4-α-glucanotransferase that elongates linear alpha-glucan chains in starch and amylose by catalyzing the transfer of one glucose unit from the non-reducing end to a new position in an acceptor, which may be triose or larger. The enzyme can be used various applications, such as for modifications of alpha-polysaccharides and is ideal for making clear size ladders of oligosaccharides larger than maltose. The enzyme was developed from metagenome DNA obtained from environmental sample from a geothermal environment. The enzyme catalyzes the formation of the alpha-1,4-glucosidic linkages. the enzyme transfers a segment of a (1->4)-alpha-d-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-d-glucan. Group: Enzymes. Synonyms: Glucan elongation enzyme. Glucan elongation enzyme. Source: Bacterial Environmental DNA. Glucan elongation enzyme. Cat No: NATE-0302. | |
| NQTrp | NQTrp, also called 1,4-Naphthoquinon-2-yl-L-tryptophan, inhibits amyloid β (Aβ) oligomerization and fibrillization (IC50 = 50 nM for formation of fibrils from Aβ1-42) to treat Alzheimer's disease. Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: NQTrp; NQ-Trp; NQ Trp; (2S)-2-[(1,4-dioxonaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid; 185351-19-3; nqtrp; TRY001; DTXSID30717912; ZINC100222454; KB-274843; N-(1,4-Dioxo-1,4-dihydronaphthalen-2-yl)-L-tryptophan; L-Tryptophan, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-; NQTrp|N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan. CAS No. 185351-19-3. Molecular formula: C21H16N2O4. Mole weight: 360.36. | |
| O-tert-Butyldimethylsilyl-benzyl Alcohol 4-(2,2,2-Trifluoroethanone) | Intermediate in the preparation of trifluoro methyl diazirine, useful as a photo-induced cross-linking probe for exploring amyloid formation. Group: Biochemicals. Alternative Names: 1- [4- [ [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] methyl] phenyl] -2, 2, 2-trifluoro-ethanone. Grades: Highly Purified. CAS No. 87736-75-2. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Phenserine | Phenserine ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine improves cognitive performance and attenuates the progression of Alzheimer's disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (-)-Eseroline phenylcarbamate; (-)-Phenserine. CAS No. 101246-66-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-103374. | |
| Preptin (rat) | Preptin, a 34-amino acid peptide hormone, is co-secreted with insulin in β-cells of the pancreas in response to glucose stimulation. Preptin is osteogenic both in vitro and in vivo and may act synergistically with other β-cell hormones insulin and amylin to stimulate bone formation in hyperinsulinemic states such as obesity. Synonyms: H-Asp-Val-Ser-Thr-Ser-Gln-Ala-Val-Leu-Pro-Asp-Asp-Phe-Pro-Arg-Tyr-Pro-Val-Gly-Lys-Phe-Phe-Lys-Phe-Asp-Thr-Trp-Arg-Gln-Ser-Ala-Gly-Arg-Leu-OH; L-alpha-aspartyl-L-valyl-L-seryl-L-threonyl-L-seryl-L-glutaminyl-L-alanyl-L-valyl-L-leucyl-L-prolyl-L-alpha-aspartyl-L-alpha-aspartyl-L-phenylalanyl-L-prolyl-L-arginyl-L-tyrosyl-L-prolyl-L-valyl-glycyl-L-lysyl-L-phenylalanyl-L-phenylalanyl-L-lysyl-L-phenylalanyl-L-alpha-aspartyl-L-threonyl-L-tryptophyl-L-arginyl-L-glutaminyl-L-seryl-L-alanyl-glycyl-L-arginyl-L-leucine. Grades: ≥95%. CAS No. 315197-73-0. Molecular formula: C181H268N48O51. Mole weight: 3932.41. | |
| Punicic acid | Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α ( TNF-α ). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain , and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Trichosanic acid. CAS No. 544-72-9. Pack Sizes: 1 mg (35.92 mM * 100 μL in Methanol). Product ID: HY-139066. | |
| ReACp53 | ReACp53 is a cell-permeable inhibitor of p53 amyloid formation that targets mutant p53 protein in primary prostate cancer. Synonyms: H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Pro-Ile-Leu-Thr-Arg-Ile-Thr-Leu-Glu-OH; L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-prolyl-L-isoleucyl-L-leucyl-L-threonyl-L-arginyl-L-isoleucyl-L-threonyl-L-leucyl-L-glutamic acid. Grades: ≥95%. Molecular formula: C108H206N52O24. Mole weight: 2617.13. | |
| ReACp53 acetate | ReACp53 acetate is an acetate form of ReACp53 that is a cell-penetrating peptide, used to inhibit p53 amyloid formation in cancer cell lines. Grades: >98.0%. Molecular formula: C110H210N52O26. Mole weight: 2677.18. | |
| TAE-1 | TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation, suggesting its potential for the treatment of Alzheimer's disease. Synonyms: 2-[4-[[4, 6-bis[4-[2- (trimethylazaniumyl) ethoxycarbonyl]phenoxy]-1, 3, 5-triazin-2-yl]oxy]benzoyl]oxyethyl-trimethylazanium triiodide. CAS No. 1414469-59-2. Molecular formula: C39H51N6O9·3I. Mole weight: 1128.6. | |
| Teplow's Amyloid β-Protein (1-40) (scrambled II) | Teplow's Amyloid β-Protein (1-40) (scrambled II) is a specially designed negative control in the Abeta40 study. Teplow's Amyloid β-Protein (1-40) does not exhibit some of the phenomena regularly observed by Abeta40 (fiber formation, oligomerization, toxicity to neurons), and has a relatively flat hydropathy profile, which may have been an advantage in some studies, for example, to avoid nonspecific interactions with cell membranes. ''Scrambled'' means that it contains the same amino acids as Abeta40, but in a different order. Synonyms: β-Amyloid (1-40) (scrambled II); H-Tyr-His-Ala-Gly-Val-Asp-Lys-Glu-Val-Val-Phe-Asp-Glu-Gly-Gly-Ala-Glu-His-Gly-Leu-Ala-Gln-Lys-Ile-Val-Arg-Gly-Phe-Gly-Val-Ser-Asp-Val-Ser-Met-Ile-His-Asn-Leu-Phe-OH. Grades: ≥95%. CAS No. 1987844-71-2. Molecular formula: C194H295N53O58S. Mole weight: 4329.86. | |
| Teplow's Amyloid β-Protein (1-42) (scrambled II) | Teplow's Amyloid β-Protein (1-42) (scrambled II) is a specially designed negative control in the Abeta42 study. Teplow's Amyloid β-Protein (1-42) does not exhibit some of the phenomena regularly observed by Abeta42 (fiber formation, oligomerization, toxicity to neurons), and has a relatively flat hydropathy profile, which may have been an advantage in some studies, for example, to avoid nonspecific interactions with cell membranes. ''Scrambled'' means that it contains the same amino acids as Abeta42, but in a different order. Synonyms: β-Amyloid (1-42) (scrambled II); H-Tyr-His-Ala-Gly-Val-Asp-Lys-Glu-Val-Val-Phe-Asp-Glu-Gly-Ala-Gly-Ala-Glu-His-Gly-Leu-Ala-Gln-Lys-Ile-Val-Arg-Gly-Phe-Gly-Val-Ser-Asp-Val-Ser-Met-Ile-His-Ile-Asn-Leu-Phe-OH. Grades: ≥95%. CAS No. 1987844-92-7. Molecular formula: C203H311N55O60S. Mole weight: 4514.03. | |
| Trimesinic Acid | Trimesinic Acid is used for multifunctional therapeutics. It shows inhibitory activity against Torpedo Californica acetylcholinesterase and prevented amyloid- β peptide aggregate formation. Group: Biochemicals. Grades: Highly Purified. CAS No. 554-95-0. Pack Sizes: 5g, 25g. Molecular Formula: C9H6O6. US Biological Life Sciences. | Worldwide |
| Xanthene-9-carboxylic Acid | Xanthene-9-carboxylic Acid is xanthrene derivative that is capable of inhibiting the TTR conformational changes facilitating amyloid fibril formation. Group: Biochemicals. Alternative Names: 9-Carboxyxanthene; 9H-Xanthen-9-carboxylic Acid; NSC 66208; Xanthanoic Acid; Xanthenecarboxylic Acid. Grades: Highly Purified. CAS No. 82-07-5. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
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