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| Product | Description | |
|---|---|---|
| BCA | BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC 50 value of 28 μM, a K i value of 43 μM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD) [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Disodium bicinchoninate. CAS No. 979-88-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15908. |  |
| BCAA Powder (2:1:1) | BCAA Powder (2:1:1). |  CA, FL & NJ |
| Bcat | Bcat. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BCAT;Benzotriazole-1-carboxamidinium tosylate. Product Category: Heterocyclic Organic Compound. CAS No. 163853-10-9. Molecular formula: C7H8N5.C7H7O3S. Mole weight: 333.37. Product ID: ACM163853109. Alfa Chemistry ISO 9001:2015 Certified. Categories: BCATP. |  |
| BCAT | Synonyms: Benzotriazole-1-Carboxamidinium Tosylate; 1H-Benzotriazole-1-carboximidamide, 4-methylbenzenesulfonate (1:1). Grades: 95%. CAS No. 163853-10-9. Molecular formula: C7H8N5.C7H7O3S. Mole weight: 333.37. |  |
| BCATc Inhibitor 2 | BCATc Inhibitor 2 is a sulfonyl hydrazide that inhibits BCATc with IC50s of 0.81 for human and IC50 s of 0.2 μM for rat. It is 15-fold selectivity over BCATm. It has also been used to block calcium influx into neurons with IC50 of 4.8 μM following inhibition of glutamate uptake and to demonstrate neuroprotective efficacy in an in vivo rat model of neurodegeneration. Synonyms: Cytosolic Branched-Chain Amino Acid Transferase Inhibitor 2. Grades: ≥98%. CAS No. 406191-34-2. Molecular formula: C16H10ClF3N2O4S. Mole weight: 418.8. | |
| Branched-chain amino acid Microencapsulated Powder (BCAA) microencapsulated powder | Branched-chain amino acid Microencapsulated Powder (BCAA) microencapsulated powder. Product ID: CDF4-0216. Molecular formula: NA. Category: Nutrient supplements. Product Keywords: Food Ingredients; Nutrients; CDF4-0216; Branched-chain amino acid Microencapsulated Powder (BCAA) microencapsulated powder; Nutrient supplements. Applications: Dietary supplements, nutritional supplements, cosmetic raw materials, etc. |  |
| LITHOL RUBIN BCA | LITHOL RUBIN BCA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 11070red;2-Naphthalenecarboxylicacid,3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-,disodiumsalt;3-hydroxy-4-((4-methyl-2-sulfophenyl)azo)-2-naphthalenecarboxylicacidisod;3-hydroxy-4-((4-methyl-2-sulfophenyl)azo)-2-naphthalenecarboxylicacidisodiumsalt;3-hydr. Product Category: Pigments. CAS No. 5858-81-1. Molecular formula: C18H12N2Na2O6S. Mole weight: 430.34. Purity: 0.96. IUPACName: disodium (4E)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3-oxonaphthalene-2-carboxylate. Product ID: ACM5858811. Alfa Chemistry ISO 9001:2015 Certified. Categories: Calcium 3-hydroxy-4-((4-methyl-2-sulphonatophenyl)azo)-2-naphthoate. | |
| [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) | [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl). Group: Monomers. CAS No. 3637-26-1. Product ID: 3-[dimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azaniumyl]propane-1-sulfonate. Molecular formula: 279.36g/mol. Mole weight: C11H21NO5S. CC (=C)C (=O)OCC[N+] (C) (C)CCCS (=O) (=O)[O-]. InChI=1S/C11H21NO5S/c1-10 (2)11 (13)17-8-7-12 (3, 4)6-5-9-18 (14, 15)16/h1, 5-9H2, 2-4H3. BCAIDFOKQCVACE-UHFFFAOYSA-N. |  |
| 3-[[2- (Methacryloyloxy) ethyl]dimethylammonio]propane-1-sulfonate | 3-[[2- (Methacryloyloxy) ethyl]dimethylammonio]propane-1-sulfonate. Group: Monomers. CAS No. 3637-26-1. Product ID: 3-[dimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azaniumyl]propane-1-sulfonate. Molecular formula: 279.36g/mol. Mole weight: C11H21NO5S. CC (=C)C (=O)OCC[N+] (C) (C)CCCS (=O) (=O)[O-]. InChI=1S/C11H21NO5S/c1-10 (2)11 (13)17-8-7-12 (3, 4)6-5-9-18 (14, 15)16/h1, 5-9H2, 2-4H3. BCAIDFOKQCVACE-UHFFFAOYSA-N. | |
| 4-Acetylphenylboronic acid | 4-Acetylphenylboronic acid is a potent inhibitor of carbonic anhydrases II( CA II ), with IC 50 s of 246 μM and 281.40 μM for bovine CA II ( bCA II ) and human CA II ( hCA II ), respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 149104-90-5. Pack Sizes: 10 g. Product ID: HY-32933. | |
| 8-Br-cAMP | 8-Br-cAMP, a synthetic cyclic adenosine monophosphate (cAMP) analog, demonstrates versatile potential in medical and biological sciences. From inhibiting platelet aggregation and inducing cellular differentiation, to regulating gene expression and advancing therapeutic research - its applications span across cancer, cardiovascular, and endocrine disorders. Its potential for enhancing cellular signaling and invigorating treatment research sets it apart as a tool for shaping the future of life sciences. Uses: Reprogramming. Synonyms: 8-Br-cAMP; BCAMP; 8-Bromo-cyclic AMP; 8-Bromoadenosine 3',5'-cyclic monophosphate; 8-bromo-cAMP; 8-Bromo-cyclic 3',5'-AMP; 8-Bromoadenosine cyclic 3',5'-phosphate; Cyclic 8-bromoadenosine 3',5'-monophosphate; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; 8-Bromoadenosine 3',5'-monophosphate; 8-bromo-3',5'-cyclic AMP; Cyclic AMP, 8-bromo; 5QO1UW05Q5; CHEBI:64211; MFCD00075580; Adenosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate); 8-bromoadenosine 3',5'-(hydrogen phosphate); (4AR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxide1111. Grades: 0.98. CAS No. 23583-48-4. Molecular formula: C10H11BrN5O6P. Mole weight: 408.1. | |
| A431+ Pervanadate Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by western blotting using anti-Phosphotyrosine. Confluent cultures of A431 cells were serum starved overnight. Cells were then either left untreated or treated with pervanadate (1 mM) for 30 minutes at 37°C Cells were lysed in 1% SDS, 1.0mM sodium ortho-vanadate, 10mM Tris (pH 7.4) buffer. Protein concentration was determined using the BCA method (Pierce) before diluting to final concentration and buffer. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. |  Worldwide |
| Alanine-Valine transaminase (Crude Enzyme) | Branched chain aminotransferase is an aminotransferase enzyme which acts upon branched-chain amino acids. It uses largely α-ketoglutarate in forming branched chain α-keto acids and glutamate. The biological function of branched chain aminotransferases (BCAT) is to catalyse the synthesis or degradation of the branched chain amino acids leucine, isoleucine, and valine. In humans, branched chain amino acids are essential and are degraded by BCATs. This product with the indicated enzyme activity was briefly purified from engineered E. coli. Applications: Nutrition. Group: Enzymes. Synonyms: Transaminase B; branched-chain amino acid aminotransferase; branched-chain amino acid-glutamate Transaminase; branched-chain aminotransferase; L-branched chain amino acid aminotransferase; glutamate-branched-chain amino acid Transaminase. Enzyme Commission Number: EC 2.6.1.42. CAS No. 9054-65-3. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. Transaminase B; branched-chain amino acid aminotransferase; branched-chain amino acid-glutamate Transaminase; branched-chain aminotransferase; L-branched chain amino acid aminotransferase; glutamate-branched-chain amino acid Transaminase. Pack: 100ml. Cat No: NATE-1821. |  |
| β-cyano-L-alanine | β-cyano-L-alanine is a reversible inhibitor of the H2S-synthesizing enzyme CSE. It blocks H2S synthesis in rat liver preparations with an IC50 value of 6.5 μM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H2S synthesis. Synonyms: BCA; beta-cyano-L-alanine; 3-Cyano-L-alanine; L-3-Cyanoalanine. Grades: ≥ 98% (TLC). CAS No. 6232-19-5. Molecular formula: C4H6N2O2. Mole weight: 114.1. | |
| Branched-chain amino acids | BCAA. CAS No. 308062-69-3. Product ID: 2-08430. |  |
| Bromochloroacetonitrile | Bromochloroacetonitrile is a by-product of the chlorine disinfection of water containing natural organic material. Bromochloroacetonitrile possesses direct acting mutagenic activity and is capable of inducing DNA strand breakage. Uses: Designed for use in research and industrial production. Additional or Alternative Names: bromochloro-acetonitril;Bromochloromethyl cyanide;BROMOCHLOROACETONITRILE;BROMOCHLOROACETONITRILE100MGNEAT;bcan. Product Category: Inhibitors. CAS No. 83463-62-1. Molecular formula: C2HBrClN. Mole weight: 154.39. Canonical SMILES: N#CC(Br)Cl. Product ID: ACM83463621. Alfa Chemistry ISO 9001:2015 Certified. | |
| Calcium Borate | Calcium Borate. Uses: Designed for use in research and industrial production. Product Category: Promotional Products. Appearance: solid. CAS No. 12007-56-6. Molecular formula: BCaH7O. Mole weight: 73.94. Purity: 95+%. Product ID: ACM12007566. Alfa Chemistry ISO 9001:2015 Certified. | |
| isoleucine 2-epimerase | A pyridoxal phosphate protein. The enzyme, characterized from the bacterium Lactobacillus buchneri, specifically catalyses racemization of nonpolar amino acids at the C-2 position. Group: Enzymes. Synonyms: BCAA racemase. Enzyme Commission Number: EC 5.1.1.21. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5380; isoleucine 2-epimerase; EC 5.1.1.21; BCAA racemase. Cat No: EXWM-5380. | |
| Jurkat Pervanadate Control Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by western blotting using anti-Phosphotyrosine. Confluent cultures of Jurkat cells were serum starved overnight. Cells were then either left untreated or treated with pervanadate (1 mM) for 30 minutes at 37°C. Cells were lysed in 1% SDS, 1.0mM sodium ortho-vanadate, 10mM Tris (pH 7.4) buffer. Protein concentration was determined using the BCA method (Pierce) before diluting to final concentration and buffer. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Jurkat+ Pervanadate Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by western blotting using anti-Phosphotyrosine. Confluent cultures of Jurkat cells were serum starved overnight. Cells were then either left untreated or treated with pervanadate (1 mM) for 30 minutes at 37°C. Cells were lysed in 1% SDS, 1.0mM sodium ortho-vanadate, 10mM Tris (pH 7.4) buffer. Protein concentration was determined using the BCA method (Pierce) before diluting to final concentration and buffer. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| L-Leucine | L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Leucine. CAS No. 61-90-5. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-N0486. | |
| L-Leucine-13C | L-Leucine- 13 C is the 13 C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 74292-94-7. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-N0486S1. | |
| L-Leucine-13C6 | Leucine- 13 C 6 is the 13 C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 201740-84-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N0486S2. | |
| L-Leucine-13C6,15N | L-Leucine- 13 C 6 , 15 N is the 13 C- and 15 N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 202406-52-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N0486S8. | |
| L-Leucine-d10 | L-Leucine-d 10 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 106972-44-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N0486S. | |
| Methazolamide | Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. Uses: Carbonic anhydrase inhibitors; diuretics. Synonyms: CL 8490; CL8490; CL-8490. Grades: >98%. CAS No. 554-57-4. Molecular formula: C5H8N4O3S2. Mole weight: 236.27. | |
| Native Baker's yeast (S. cerevisiae) Inorganic Pyrophosphatase | Pyrophosphatase (or inorganic pyrophosphatase) is an enzyme (EC 3.6.1.1) that catalyzes the conversion of one molecule of pyrophosphate to two phosphate ions. This is a highly exergonic reaction, and therefore can be coupled to unfavorable biochemical transformations in order to drive these transformations to completion. The functionality of this enzyme plays a critical role in lipid metabolism (including lipid synthesis and degradation), calcium absorption and bone formation, and DNA synthesis,as well as other biochemical transformations. This ubiquitous enzyme serves to drive metabolic reactions that produce pyrophosphate, since these reactions typically have...phohydrolase; inorganic pyrophosphatase; EC 3.6.1.1; 9024-82-2; iphosphate phosphohydrolase. Enzyme Commission Number: EC 3.6.1.1. CAS No. 9024-82-2. Inorganic pyrophosphatase. Mole weight: 71 kDa (homodimer consisting of two equal subunits of molecular weight 32-35 kDa). Activity: Type I, > 1,000 units/mg protein (BCA); Type II, > 500 units/mg protein (E1%/280). Storage: -20°C. Form: Type I, lyophilized powder containing 90% buffer salts; Type II, Lyophilized powder containing 85% buffer salts. Source: Baker's yeast (S. cerevisiae). Pyrophosphate phosphohydrolase; inorganic pyrophosphatase; EC 3.6.1.1; 9024-82-2; iphosphate phosphohydrolase. Cat No: NATE-0354. | |
| Native Bovine Lipoprotein Lipase | Lipoprotein lipase (LPL) (EC 3.1.1.34) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into two free fatty acids and one monoacylglycerol molecule. It is also involved in promoting the cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. LPL requires ApoC-II as a cofactor. LPL is attached to the luminal surface of endothelial cells in capillaries by the protein glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1) and by heparin sulfated proteoglycans. It is most widely distributed in adipose, heart, and skeletal muscle tissue, as well as in lactating mammary glands. Group: Enzymes. Synony. Enzyme Commission Number: EC 3.1.1.34. CAS No. 9004-2-8. LPL. Activity: > 2,000 units/mg protein (BCA). Storage: 2-8°C. Form: ammonium sulfate suspension; Suspension in 3.8 M ammonium sulfate, 0.02 M Tris HCl, pH 8.0. Source: Bovine milk. Species: Bovine. lipoprotein lipase; clearing factor lipase; diglyceride lipase; diacylglycerol lipase; postheparin esterase; diglyceride lipase; postheparin lipase; diacylglycerol hydrolase; lipemia-clearing factor; EC 3.1.1.34; 9004-02-8; LPL. Cat No: NATE-0416. | |
| Native Bovine Pyruvate Carboxylase | Pyruvate carboxylase catalyzes the carboxylation of pyruvate to oxaloacetate. Pyruvate carboxylase is a mitochondrial protein that has a biotin prosthetic group that requiries magnesium or manganese and acetyl CoA. Applications: Pyruvate is critical for gluconeogenesis, lipogenesis, glyceroneogenesis, neurotransmitter biosynthesis and glucose-induced insulin, and is used to study these pr ocesses. the enzyme from creative enzymes has been used as a positive control during the assay of pyruvate carboxylase activity in cell-free extracts of corynebacterium glutamicum. Group: Enzymes. Synonyms: Pyruvate carboxylase; PC; EC 6.4.1.1; 9014-19-1; pyruvic carboxylase. Enzyme Commission Number: EC 6.4.1.1. CAS No. 9014-19-1. PC. Activity: 5-25 units/mg protein (BCA). Storage: -20°C. Form: buffered aqueous glycerol solution; Solution in 50% glycerol containing 0.05 M Tris-HCl, pH 7.4, 2 mM magnesium acetate and 1 mM EDTA. Source: Bovine liver. Species: Bovine. Pyruvate carboxylase; PC; EC 6.4.1.1; 9014-19-1; pyruvic carboxylase. Cat No: NATE-0508. | |
| Native Human erythrocytes Acetylcholinesterase | Acetylcholinesterase, also known as AChE or acetylhydrolase, is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. It belongs to carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. The activity obtained using acetylcholine as substrate is 30-100 times that obtained with butyrylcholine, using acetylcholinesterase from electric eel. Applications: Acetylcholinesterase (ache) from creative enzymes has been used in the structure-activity study of phosphoramido acid esters as inhibitors of ache. Group: Enzymes. Synonyms: true cholinesterase; choline esterase I; cholines. Enzyme Commission Number: EC 3.1.1.7. CAS No. 9000-81-1. Acetylcholinesterase. Mole weight: ~80 kDa. Activity: > 500 units/mg protein (BCA). Storage: 2-8°C. Form: buffered aqueous solution. Solution in 20 mM HEPES, pH 8.0, containing 0.1% TRITON X-100. Source: Human erythrocytes. Species: Human. true cholinesterase; choline esterase I; cholinesterase; acetylthiocholinesterase; acetylcholine hydrolase; acetyl; β-methylcholinesterase; AcCholE; EC 3.1.1.7; 9000-81-1; Acetylcholinesterase; AChE; acetylhydrolase. Cat No: NATE-0019. | |
| Nicosulfuron | Nicosulfuron is efficient, harmless, antifungal and selective herbicide belonging to the sulfonylurea family. Nicosulfuron is also a photosynthetic system inhibitor and inhibits acetolactate synthase (ALS) enzyme activity. Nicosulfuron degradation by Plectosphaerella cucumerina AR1 is glucose concentration dependent in planktonic lifestyle. Nicosulfuron enhances the glycolysis pathway and tricarboxylic acid cycle to improve the adaptability of sweet maize. Nicosulfuron reduces the synthesis of branched-chain amino acids (BCAAs) , which is proming for maize cultivation [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 111991-09-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-B1876. | |
| Pigment Red 57:1 | Pigment Red 57:1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-2-naphthalenecarboxylicacicalci;C.I.Pigmentred57:1;LitholrubineBK;PigmentlitholrubineA6B;PigmentlitholrubineBK;PIGMENT RED 57;LITHOL RUBIN BCA;LITHOL RUBINE NA. Product Category: Pigments. CAS No. 5281-4-9. Molecular formula: C18H12N2Na2O6S. Mole weight: 430.34. Product ID: ACM5281049. Alfa Chemistry ISO 9001:2015 Certified. | |
| Rad6 Inhibitor (4-Amino-6-(phenylamino)-[1,3,5]triazin-2-yl)methyl-4-nitrobenzoate, (4-Amino-6-(phenylamino)-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate, TZ9, TZ-9, TZ 9, HHR6 Inhibitor) | A cell-permeable triazine compound that directly targets human E2 Ubiquitin-conjugating enzyme Rad6B/HHR6B catalytic site via noncovalent interactions and effectively inhibits Rad6B-Ub thioester bond formation as well as subsequent substrate ubiquitination without affecting UbcH5B/UBE2D2-catalyzed BCA2 ubiquitination. Shown to inhibit the proliferation of high Rad6B-expressing MDA-MB-231 (IC50 = 6uM in 72h), but not the low Rad6B-expressing, non-transformed MCF10A, via G2/M arrest and apoptosis induction. Two known cellular Rad6 substrates, beta-catenin and PCNA, are reported to be downregulated following 24h inhibitor treatment in MDA-MB-231 cultures (0.5 to 5uM).CAS Number:002789-86-7. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Primary Target: Rad6B/HHR6B. US Biological Life Sciences. | Worldwide |
| Spautin-1 (6-fluoro-N- [4-fluorobenzyl] quinazolin-4-amine, Specific and Potent AUtophagy Inhibitor 1, C43, Autophagy Inhibitor II) | A quinazolin compound that acts as a specific and potent inhibitor of autophagy and promotes Vps34 PI 3-kinase complex degradation by blocking the activity of USP 10 (IC50 = 580nM) and USP 13 (IC50 = 690nM) deubiquitinating enzymes. However, it does not affect the lipid kinase activity of Vps34. Also shown to reduce the level of cytoplasmic and nuclear p53. Sensitizes breast cancer cell lines (BCAP37, MCF-7, and BT549) to apoptosis under conditions of nutritional deprivation. Also shown to inhibit etoposide-induced cell death in Bax/Bak double knockout (DKO) cells. Normal cell lines (e.g., MDCK cells) do not undergo autophagy in the presence of Spautin-1. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Theliatinib | Theliatinib is a highly potent, ATP-competitive EGFR inhibitor with 50-fold greater selectivity for EGFR compared to 72 other kinases. It exhibits anti-tumor activity in multiple xerographs such as A-431, Bcap-37 and Fadu. Synonyms: HMPL-309; (3aR,6aR)-N-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-5-carboxamide. CAS No. 1353644-70-8. Molecular formula: C25H26N6O2. Mole weight: 442.51. | |
| Threonine Deaminase (Crude Enzyme) | Threonine ammonia-lyase, also commonly referred to as threonine deaminase or threonine dehydratase, is an enzyme responsible for catalyzing the conversion of L-threonine into alpha-ketobutyrate and ammonia. Alpha-ketobutyrate can be converted into L-isoleucine, so threonine ammonia-lyase functions as a key enzyme in BCAA synthesis. It employs a pyridoxal-5-phosphate cofactor, similar to many enzymes involved in amino acid metabolism. It is found in bacteria, yeast, and plants, though most research to date has focused on forms of the enzyme in bacteria. This enzyme was one of the first in which negative feedback inhibition by the end product of a metabolic pathway was directl...es. Synonyms: threonine deaminase; L-serine dehydratase; serine deaminase; L-threonine dehydratase; threonine dehydrase; L-threonine deaminase; threonine dehydratase; L-threonine hydro-lyase (deaminating); L-threonine ammonia-lyase. Enzyme Commission Number: EC 4.3.1.19. CAS No. 9024-34-4. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. threonine deaminase; L-serine dehydratase; serine deaminase; L-threonine dehydratase; threonine dehydrase; L-threonine deaminase; threonine dehydratase; L-threonine hydro-lyase (deaminating); L-threonine ammonia-lyase. Pack: 100ml. Cat No: NATE-1853. | |
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