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| Product | Description | |
|---|---|---|
| 3D Printing Graphene Ink | 3D Printing Graphene Ink. Uses: Direct syringe extrusion into solid fibres or structures-can be extruded by hand or by machine, from any standard syringe. dip-coating. spin-coating. casting. fusing-separately produced solid 3d printing graphene objects can be joined via application of additional ink at points of contact. Group: 3d printing materials carbon nano materials. CAS No. 7782-42-5. |  |
| 3D Printing Graphite Ink | 3D Printing Graphite Ink. Uses: Direct syringe extrusion into solid fibres or structures-can be extruded by hand or by machine, from any standard syringe. dip-coating. spin-coating. casting. fusing-separately produced solid 3d printing graphene objects can be joined via application of additional ink at points of contact. Group: 3d printing materials carbon nano materials. | |
| Camphor | Camphor. Synonyms: (±)-Camphor, 1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one. CAS No. 76-22-2. Pack Sizes: 100, 500 g in poly bottle. Product ID: CDC10-0191. Molecular formula: C10H16O. Category: Flavoring Chemical Agents. Product Keywords: Cosmetic Ingredients; Flavoring Chemical Agents; Camphor; CDC10-0191; 76-22-2; C10H16O; (±)-Camphor, 1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one; 200-945-0; MFCD00074738; 76-22-2. Purity: 0.96. EC Number: 200-945-0. Solubility: Ethanol: soluble 1 g/L, clear, colorless. Quality Level: 100. Application: Camphor was used in the synthesis of single-walled nanotubes by chemical vapor deposition. It was used in two-phase based hollow fibre liquid-phase microextraction procedure for migration analysis of food packagings containing essential oils. Boiling Point: 204 °C (lit.). Melting Point: 175-177 °C (lit.). Product Description: Camphor is a novel carbon nanotube precursor. |  |
| Perylene | Perylene molecules are fluorescent in nature. Ultraviolet photoemission spectroscopy and low energy electron diffraction of the structure of 4Å thick perylene dye layers adsorbed on the surface of Ru (0001) has been investigated. Uses: Perylene was used in the fabrication of gold nanoparticle (aunp) : poly(ethylene oxide) (peo) nanocomposite thin films. perylene nanoparticles doped into poly(acrylonitrile) (pan) were used to monitor the temperature change caused due to the nanoparticle plasmon-mediated heating within the polymer fibres and films. ordered epitaxial perylene films may be used to fabricate a multilayered electroluminescent device. Group: Carbon nano materials molecular conductorsorganic light-emitting diode (oled) materials other electronic materials sublimed materials. Alternative Names: peri-Dinaphthalene. CAS No. 198-55-0. Pack Sizes: 1, 5 g in glass bottle. Product ID: Perylene. Molecular formula: 252.3. Mole weight: C20H12. C1=CC2=C3C (=C1)C4=CC=CC5=C4C (=CC=C5)C3=CC=C2. InChI= 1S / C20H12 / c1-5-13-6-2-11-17-18-12-4-8-14-7-3-10 -16 (20 (14) 18) 15 (9-1) 19 (13) 17 / h1-12H. CSHWQDPOILHKBI-UHFFFAOYSA-N. 95%+. | |
| Thulium(III) carbonate hydrate | Thulium(III) carbonate hydrate. Uses: Thulium(+3) cation trinitrate hexahydrate has specialized uses in ceramics, glass, phosphors, lasers, also is the important dopant for fibre amplifiers. thulium(+3) cation trinitrate hexahydrate is a highly water soluble crystalline thulium source for uses compatible with nitrates and lower (acidic) ph. thulium(+3) cation trinitrate hexahydrate can be manufactured as solutions at specified stoichiometries. Additional or Alternative Names: THULIUM CARBONATE HYDRATE; dithulium(3+) ion hydrate triCO3; THULIUM CARBONATE, 99.9%; CTK5F8067; 87198-17-2; DTXSID80648489. Product Category: Heterocyclic Organic Compound. CAS No. 87198-17-2. Molecular formula: C3H2O10Tm2. Mole weight: 535.907g/mol. IUPACName: thulium(3+);tricarbonate;hydrate. Canonical SMILES: C(=O)([O-])[O-].C(=O)([O-])[O-].C(=O)([O-])[O-].O.[Tm+3].[Tm+3]. Product ID: ACM87198172. Alfa Chemistry ISO 9001:2015 Certified. Categories: 621-830-5. |  |
| 1-[1, 1-Dimethylethoxy) ?carbonyl]?-?4-piperidinepropanoic Acid Methyl Ester | 1-[1, 1-Dimethylethoxy) ?carbonyl]?-?4-piperidinepropanoic Acid Methyl Ester is used to prepare arginylglycylaspartic acid derivatives as fibrinogen receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 162504-75-8. Pack Sizes: 100mg, 500 mg. Molecular Formula: C14H25NO4, Molecular Weight: 271.35. US Biological Life Sciences. |  Worldwide |
| 1,4-Dihydro-4-oxo-3-quinolinecarbonyl Chloride | 1,4-Dihydro-4-oxo-3-quinolinecarbonyl Chloride is an impurity of Ivacaftor, a drug used in the treatment of cystic fibrosis. Synonyms: 4-Oxo-1,4-dihydroquinoline-3-carbonyl Chloride. CAS No. 80761-61-1. Molecular formula: C10H6ClNO2. Mole weight: 207.61. |  |
| 2,4-Di-tert-butyl-5-nitrophenyl-d10 Methyl Carbonate | 5-Nitro-2,4-bis(1,1-dimethylethyl)phenyl-carbonic Acid Methyl Ester-d10 is an intermediate used in the synthesis of Ivacaftor (4-tertbutyl-d9) (Major) (I940603), which is isotopically labeled form of Ivacaftor (I940600), that is used in the treatment of cystic fibrosis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C16H13D10NO5, Molecular Weight: 319.42. US Biological Life Sciences. | Worldwide |
| 2,4-Di-tert-butyl-6-nitrophenyl Methyl Carbonate + 2,4-Di-tert-butyl-5-nitrophenyl Methyl Carbonate (Mixture of Regioisomers) | 2,4-Di-tert-butyl-6-nitrophenyl Methyl Carbonate + 2,4-Di-tert-butyl-5-nitrophenyl Methyl Carbonate (Mixture of Regioisomers) is an intermediate of Ivacaftor, a drug used in the treatment of cystic fibrosis. Molecular formula: C16H23NO5. Mole weight: 309.36. | |
| 2,4-Di-tert-butyl-6-nitrophenyl Methyl Carbonate + 2,4-Di-tert-butyl-5-nitrophenyl Methyl Carbonate. (Mixture of Regioisomers) | 2,4-Di-tert-butyl-6-nitrophenyl Methyl Carbonate + 2,4-Di-tert-butyl-5-nitrophenyl Methyl Carbonate (Mixture of Regioisomers) is an intermediate in the synthesis of Ivacaftor (4-tertbutyl-d9) (Major) (I940603). Ivacaftor (4-tertbutyl-d9) (Major) is isotopically labelled form of Ivacaftor (I940600), which is used in the treatment of cystic fibrosis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C16H23NO5 + C16H23NO5. US Biological Life Sciences. | Worldwide |
| 2- (Hydroxy methyl ) -1-phenylcyclopropane carbonitrile | 2- (Hydroxy methyl ) -1-phenylcyclopropane carbonitrile is the degradation product of Milnacipran (M344600), which is a selective norepinephrine and serotonin reuptake inhibitor approved for management of fibromyalgia; antidepressant. Group: Biochemicals. Grades: Highly Purified. CAS No. 60788-55-8. Pack Sizes: 10mg, 50mg. Molecular Formula: C11H11NO, Molecular Weight: 173.21. US Biological Life Sciences. | Worldwide |
| (2S) -N-[ (1, 1-Dimethylethoxy) carbonyl]-L-alanyl- (2S) -2-hydroxy-3-methylbutanoyl-L-alanyl-2-hydroxy-3-methyl-butanoic Acid | (2S) -N-[ (1, 1-Dimethylethoxy) carbonyl]-L-alanyl- (2S) -2-hydroxy-3-methylbutanoyl-L-alanyl-2-hydroxy-3-methyl-butanoic Acid binds the PDZ domain of the Dishevelled (Dvl) protein. It is Wnt signaling inhibitor that inhibits proliferation, migration and TGF- β-induced differentiation of fibroblasts in vitro. (2S) -N-[ (1, 1-Dimethylethoxy) carbonyl]-L-alanyl- (2S) -2-hydroxy-3-methylbutanoyl-L-alanyl-2-hydroxy-3-methyl-butanoic Acid also suppresses the accumulation of collagen I, α-SMA, and TGF- β1. Group: Biochemicals. Grades: Highly Purified. CAS No. 144678-63-7. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H36N2O9, Molecular Weight: 460.52. US Biological Life Sciences. | Worldwide |
| 3- (4- (2-Butyl-5-methylsulfonamido) benzofuran-3-carbonyl) phenoxy) propyl Methanesulfonate | 3- (4- (2-Butyl-5-methylsulfonamido) benzofuran-3-carbonyl) phenoxy) propyl Methanesulfonate is an impurity of Dronedarone (D679445), a drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias. Group: Biochemicals. Grades: Highly Purified. CAS No. 1310430-09-1. Pack Sizes: 10mg, 50mg. Molecular Formula: C24H29NO8S2, Molecular Weight: 523.62. US Biological Life Sciences. | Worldwide |
| 6-Amino-2,4-di-tert-butylphenyl Methyl Carbonate | 6-Amino-2,4-di-tert-butylphenyl Methyl Carbonate is an intermediate of Ivacaftor, a drug used in the treatment of cystic fibrosis. Synonyms: 2-amino-4,6-di-tert-butylphenyl methyl carbonate; 2-Amino-4,6-bis(2-methyl-2-propanyl)phenyl methyl carbonate; Carbonic acid, 2-amino-4,6-bis(1,1-dimethylethyl)phenyl methyl ester. Molecular formula: C16H25NO3. Mole weight: 279.37. | |
| Aaf-Arg-OH HCl | Aaf-Arg-OH HCl, a substrate of carboxypeptidase B-type enzymes, has been used to determine the activation of TAFI (thrombin activatable fibrinolysis inhibitor, carboxypeptidase U) by thrombin and thrombin-thrombomodulin. Synonyms: N-(4-Methoxyphenylazoformyl)-Arg-OH HCl; N2-{[(4-Methoxyphenyl)diazenyl]carbonyl}-L-arginine hydrochloride (1:1); L-Arginine, N2-[[2-(4-methoxyphenyl)diazenyl]carbonyl]-, hydrochloride (1:1). Grades: ≥95% by HPLC. CAS No. 442158-31-8. Molecular formula: C14H20N6O4.HCl. Mole weight: 372.81. | |
| AM 966 | AM966, a LPA1 receptor antagonist, has been found to restrain lung fibrosis in mouse model. IC50: 17 nM. Uses: Am966 is a lpa1 receptor antagonist that has been found to restrain lung fibrosis in mouse model. Synonyms: AM-966; AM 966; AM966; 2-[4-[4-[4-[[(1R)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]phenyl]phenyl]aceticacid;AM966;AM-966;UNII-CEO54NH393;1228690-19-4;(R)-2-(4'-(4-(((1-(2-Chlorophenyl)ethoxy)carbonyl)amino)-3-methylisoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acet. Grades: 95%. CAS No. 1228690-19-4. Molecular formula: C27H23ClN2O5. Mole weight: 490.93. | |
| Boc-L-β-homoproline | Boc-L-β-homoproline is an amino acid derivative which is a reagent in the synthesis of dihydroisoxazole inhbitors of human transglutaminase 2, an enzyme that catalyzes the modification of glutamine residues. This enzyme has been implicated in numerous inflmmatory, fibrotic and other diseases. Synonyms: Boc-L-β-HomoPro-OH; (S)-2-(1-Boc-2-pyrrolidinyl)acetic acid; (S)-2-Carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester; Boc-L-beta-homoproline; (S)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)acetic acid; BOC-BETA-HOPRO-OH; 2-[(2S)-1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl]acetic acid; [(2s)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]acetic acid; Boc-beta-Pro-OH; Boc-beta-Homopro-OH; Boc-I(2)-HoPro-OH; Boc-Pro-(C#CH2)OH; Boc beta Homopro OH; Boc beta Pro OH; BOC BETA HOPRO OH. Grades: ≥ 98% (HPLC). CAS No. 56502-01-3. Molecular formula: C11H19NO4. Mole weight: 229.28. | |
| CFTR Activator, Cact-A1 | A cell-permeable, non-toxic aminopyrazolocarbonitr i le compound that acts as a potent, selective, reversible and cAMP-independent activator of CFTR-dependent Cl- channel in airway epithelial cells (EC50 = 1.6uM in CFTR-expressing Fisher rat thyroid cells). Also shown to activate deltaF508-CFTR in primary CF-HBE cell cultures (EC50 = 3.5uM). Reported to directly bind to the same site as CFTRinh-172. Does neither elevate intracellular cAMP levels nor appear to have any requirement for cAMP agonist, such as forskolin. Shown to additively potentiate the G551D-CFTR Cl- current activated by forskolin with CFTR potentiator, VX-770. Exerts no effect on either Ca2+-activated Cl- channel (TMEM16A) or intracellular Ca2+ levels. Group: Biochemicals. Alternative Names: Cystic Fibrosis Transmembrane Conductance Regulator Activator, Cact-A1, 5-((Z)-2-(2-(Allyloxy)phenyl)-1-cyanovinyl)-3-amino-1H-pyrazole-4-carbonitrile, (Z)-3-(2-(2-(Allyloxy)phenyl)-1-cyanovinyl)-5-amino-1H-pyrazole-4-carbonitrile. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O. US Biological Life Sciences. | Worldwide |
| CHIR-99021 | CHIR-99021 (CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. It enhances reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs in combination with tranylcypromine. It also induces cardiomyocyte differentiation from human embryonic stem (ES). Uses: Potential antineoplastic agent. Synonyms: CHIR-99021; CT99021; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile. Grades: >98%. CAS No. 252917-06-9. Molecular formula: C22H18Cl2N8. Mole weight: 465.342. | |
| Dabigatran Acyl-O-2-D-Glucuronide Trifluoroacetic Acid Salt | Dabigatran Acyl-O-2-D-Glucuronide Trifluoroacetic Acid Salt is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: N-[[2-[[[4- (Aminoiminomethyl) phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β -Alanine 2-Ester with β-D-Glucopyranuronic Acid. Molecular formula: C33H34N7O10F3. Mole weight: 761.67. | |
| Dabigatran Acyl-O-3-D-Glucuronide Trifluoroacetic Acid Salt | Dabigatran Acyl-O-3-D-Glucuronide Trifluoroacetic Acid Salt is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: N-[[2-[[[4- (Aminoiminomethyl) phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β -alanine 3-Ester with β-D-Glucopyranuronic Acid. Molecular formula: C33H34N7O10F3. Mole weight: 761.67. | |
| Dabigatran Acyl-O-4-D-Glucuronide Trifluoroacetic Acid Salt | Dabigatran Acyl-O-4-D-Glucuronide Trifluoroacetic Acid Salt is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: N-[[2-[[[4- (Aminoiminomethyl) phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β -alanine 4-Ester with β-D-Glucopyranuronic Acid. Molecular formula: C33H34N7O10F3. Mole weight: 761.67. | |
| Dabigatran Carboxamide Ethyl Ester | Dabigatran Carboxamide Ethyl Ester is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: Dabigatran Impurity 74; N-[[2-[[[4-(Aminocarbonyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine Ethyl Ester; Dabigatran Etexilate Mesylate Impurity B. Grades: 98%. CAS No. 1422435-40-2. Molecular formula: C19H20N4O3. Mole weight: 352.39. | |
| Dabigatran Etexilate Impurity 8 | Dabigatran Etexilate Impurity 8 is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: Ethyl N-[ (2-{[ (4-{N- (chloromethyl) -N'-[ (hexyloxy) carbonyl]carbamimidoyl}phenyl) amino]methyl}-1-methyl-1H-benzimidazol-5-yl) carbonyl]-N-2-pyridinyl-β -alaninate. Molecular formula: C35H42ClN7O5. Mole weight: 676.22. | |
| Dabigatran Etexilate Propanoate | Dabigatran Etexilate Propanoate is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: Propyl 3- (2- ( ( (4- (N- ( (Hexyloxy) carbonyl) carbamimidoyl) phenyl) amino) methyl) -1-methyl-N- (pyridin-2-yl) -1H-benzo[d]imidazole-5-carboxamido) propanoate; Dabigatran Impurity 38. CAS No. 1304574-20-6. Molecular formula: C35H43N7O5. Mole weight: 641.77. | |
| Dabigatran Impurity | Dabigatran Impurity is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: Ethyl 3- (2- ( ( (4- (N- ( (2-ethylbutoxy) carbonyl) carbamimidoyl) phenyl) amino) methyl) -1-methyl-N- (pyridin-2-yl) -1H-benzo[d]imidazole-5-carboxamido) propanoate; CBDA 510 BS. CAS No. 1873316-01-8. Molecular formula: C34H41N7O5. Mole weight: 627.73. | |
| Dabigatran Impurity 28 | Dabigatran Impurity 28 is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: Ethyl 2-{[ (4-{[ (hexyloxy) carbonyl]carbamoyl}phenyl) amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylate. CAS No. 1807758-61-7. Molecular formula: C26H32N4O5. Mole weight: 480.57. | |
| Dabigatran Impurity 31 | Dabigatran Impurity 31 is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: Ethyl 3-{[(2-{[(4-{6-[({5-[(3-ethoxy-3-oxopropyl)(2-pyridinyl)carbamoyl]-1-methyl-1H-benzimidazol-2-yl}methyl)amino]-4-oxo-4,5-dihydro-1,3,5-triazin-2-yl}phenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl](2-pyridinyl)amino}propa. Molecular formula: C49H49N13O7. Mole weight: 932.02. | |
| Dabigatran Impurity 53 | Dabigatran Impurity 53 is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: N- [ [2- [ [ [4- [Imino [ [ [ (2-methylpentyl) oxy] carbonyl] amino] methyl] phenyl] amino] methyl] -1-methyl-1H-benzimidazol-5-yl] carbonyl] -N-2-pyridinyl-β -alanine ethyl ester. CAS No. 2096992-14-0. Molecular formula: C34H41N7O5. Mole weight: 627.75. | |
| Dabigatran Impurity 54 | Dabigatran Impurity 54 is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: 2- [ [ [4- [ (Z) -Amino [ [ (hexyloxy) carbonyl] imino] methyl] phenyl] amino] methyl] -1-methyl-1H-benzimidazole-5-carboxylic Acid. Grades: >90%. CAS No. 1848337-06-3. Molecular formula: C24H29N5O4. Mole weight: 451.53. | |
| Dabigatran Impurity 63 | Dabigatran Impurity 63 is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: Isobutyl 3- (2- ( ( (4- (N- ( (hexyloxy) carbonyl) carbamimidoyl) phenyl) amino) methyl) -1-methyl-N- (pyridin-2-yl) -1H-benzo[d]imidazole-5-carboxamido) propanoate. Molecular formula: C36H45N7O5. Mole weight: 655.8. | |
| Dabigatran Impurity 71 | Dabigatran Impurity 71 is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: N- [ [2- [ [ [4- [Imino [ [ [ (3-methylpentyl) ?oxy] ?carbonyl] ?amino] ?methyl] ?phenyl] ?amino] ?methyl] ?-1-methyl-1H-benzimidazol-5-yl] ?carbonyl] ?-N-2-pyridinyl-β -Alanine Ethyl Ester. CAS No. 2225986-94-5. Molecular formula: C34H41N7O5. Mole weight: 627.75. | |
| Dabigatran Impurity 77 | Dabigatran Impurity 77 is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: DBG-3A Dihexyl Mesylate; (Z)-Ethyl 3- (3- ( ( (Hexyloxy) carbonyl) amino) -4- (2- ( (4- (N'- ( (hexyloxy) carbonyl) carbamimidoyl) phenyl) amino) -N-methylacetamido) -N- (pyridin-2-yl) benzamido) propanoate methanesulfonate. CAS No. 1643392-59-9. Molecular formula: C41H55N7O8. Mole weight: 773.93. | |
| ELN 441958 | ELN441958 is a novel, potent and selective bradykinin B1 receptor antagonist with Ki value of 0.26 nM. It competitively inhibited the binding of the agonist [3H]DAKD to the human B1 receptor in IMR-90 lung fibroblast cell membranes. It is highly selective for B1 over B2 receptors and >500/ 2000-fold selective for the B1 over μ/δ-opioid receptor. It also inhibited human μ-, δ-, κ- opioid receptors and muscarinic M1 receptor with Ki values of 0.13, 0.69, 1.5 and 0.37 μM, respectively. It exhibited good permeability and metabolic stability in vitro. It exhibited high oral bioavailability and moderate plasma half-lives in rats and rhesus monkeys. It does not inhibit the activation of the human bradykinin B2 receptor at concentrations up to 10 μM. It has a moderate clearance and volume of distribution in both species following i.v. administration, consistent with the high metabolic stability in rat, rhesus, and human microsomes. Uses: Eln441958 exhibited high oral bioavailability and moderate plasma half-lives. Synonyms: ELN441958; ELN 441958; ELN-441958;7-Chloro-2-[3-[[9-(pyridin-4-yl)-3,9-diazaspiro[5.5]undecan-3-yl]carbonyl]phenyl]-2,3-dihydroisoindol-1-one. Grades: >98%. CAS No. 913064-47-8. Molecular formula: C29H29ClN4O2. Mole weight: 501.02. | |
| ERK5-IN-2 | ERK5-IN-2 is a submicromolar selective ERK5 inhibitor with oral activity, which can inhibit tumor xenograft growth and basic fibroblast growth factor (bFGF)-driven Matrigel plug angiogenesis. Synonyms: 4-(2-Bromanyl-6-Fluoranyl-Phenyl)Carbonyl-{N}-Pyridin-3-Yl-1{H}-Pyrrole-2-Carboxamide; SCHEMBL17607180; BCP32587; EX-A4938. Grades: 98%. CAS No. 1888305-96-1. Molecular formula: C17H11BrFN3O2. Mole weight: 388.2. | |
| Fibronectin CS1 Peptide | Fibronectin CS1 Peptide lacks a domain containing Arg-Gly-Asp, and it can effectively inhibit tumor metastasis in both spontaneous and experimental metastatic models. Synonyms: Fibronectin CS-1 Fragment (1978-1985); H-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr-OH; L-alpha-glutamyl-L-isoleucyl-L-leucyl-L-alpha-aspartyl-L-valyl-L-prolyl-L-seryl-L-threonine; (3S,6S,9S,12S,15S)-15-amino-12-sec-butyl-3-((S)-2-((S)-1-((1S,2R)-1-carboxy-2-hydroxypropylamino)-3-hydroxy-1-oxopropan-2-ylcarbamoyl)pyrrolidine-1-carbonyl)-6-(carboxymethyl)-9-isobutyl-2-methyl-5,8,11,14-tetraoxo-4,7,10,13-tetraazaoctadecan-18-oic acid. Grades: ≥95%. CAS No. 136466-51-8. Molecular formula: C38H64N8O15. Mole weight: 872.96. | |
| Losartan Related Compound B | Des[2'-(1H-tetrazol-5-yl)] 2-Cyanolosartan is a derivative of Losartan Potassium, an angiotensin II antagonist and is commonly used to significantly reduce risk of new onset atrial fibrillation and associated stroke in high-risk patients. Synonyms: Des[2'-(1H-tetrazol-5-yl)] 2-Cyanolosartan; 4'-[[2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-[1,1'-biphenyl]-2-carbonitrile; 2-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)methyl]-5-hydroxymethylimidazole; 4'-(2-Butyl-4-chloro-5-hydroxymethyl-. Grades: > 95%. CAS No. 114772-55-3. Molecular formula: C22H22ClN3O. Mole weight: 379.88. | |
| MDM2 Antagonist IV, Nutlin-3a ((-)-4-(4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl)piperazine-2-one) | A cell-permeable and highly potent active enantiomer of Nutlin-3 that binds to the p53-binding pocket and blocks the interaction of p53 and MDM2 (IC50=90nM). Exhibits over 150-fold greater affinity for MDM2 than its less active enantiomer, Nutlin-3b. Induces p53 mediated apoptosis by both transcription-dependent and independent mechanisms. Shown to greatly potentiate the cytotoxic effects of chemotherapeutic agents and reduce tumor burden in vivo. Also shown to overcome ATM-mediated resistance to fludarabine in chronic lymphocyte leukemia. Cells treated with Nutlin-3a permanently lose their ability to proliferate and enter into a pattern of permanent senescence. Mouse embryonic fibroblasts with p53+/+ MEFs show significantly reduced reprogramming capabilities following Nutlin-3a treatment. Group: Biochemicals. Grades: Highly Purified. CAS No. 675576-98-4. Pack Sizes: 5mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences. | Worldwide |
| N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide | N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide is an intermediate of Ivacaftor, a drug used in the treatment of cystic fibrosis. Synonyms: Carbonic Acid 5-[[(1,4-Dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl Methyl Ester; 2,4-Di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate; 2,4-Bis(2-methyl-2-propanyl)-5-{[(4-oxo-1,4-dihydro-3-quinolinyl)carbonyl]amino}phenyl methyl carbonate. Grades: ≥95%. CAS No. 1246213-45-5. Molecular formula: C26H30N2O5. Mole weight: 450.53. | |
| N-Nitroso Dabigatran Etexilate | N-Nitroso Dabigatran Etexilate is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: ethyl 3- (2- ( ( (4- (N- ( (hexyloxy) carbonyl) carbamimidoyl) phenyl) (nitroso) amino) methyl) -1-methyl-N- (pyridin-2-yl) -1H-benzo[d]imidazole-5-carboxamido) propanoate. Grades: 98%. Molecular formula: C34H40N8O6. Mole weight: 656.74. | |
| N-Nitroso Dabigatran Impurity 8 | N-Nitroso Dabigatran Impurity 8 is an impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Synonyms: ethyl 3- (2- ( ( (4- ( ( (hexyloxy)carbonyl)carbamoyl)phenyl) (nitroso)amino) methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate. Molecular formula: C34H39N7O7. Mole weight: 657.73. | |
| NSC 668036 | NSC-668036 is a Wnt signaling inhibitor, binding to the PDZ domain of the dishevelled protein. It can inhibit proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. Synonyms: NSC 668036; NSC668036; NSC-668036; N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine-(1S)-1-carboxy-2-methylpropyl ester. Grades: ≥98% by HPLC. CAS No. 144678-63-7. Molecular formula: C21H36N2O9. Mole weight: 460.52. | |
| UK 370106 | UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor (IC50 = 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14, respectively). UK 370106 inhibits fibronectin cleavage (IC50 = 320 nM), and substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers. Uses: The treatment of chronic dermal ulcers. Synonyms: UK 370106; UK370106; UK-370106; (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid; (3R)-3-[[(2S)-1-[[(1S)-2-methoxy-1-phenylethyl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]-6-(3-methyl-4-phenylphenyl)hexanoic acid. Grades: ≥95% by HPLC. CAS No. 230961-21-4. Molecular formula: C35H44N2O5. Mole weight: 572.73. | |
| YM758 | YM758 is a novel 'funny' If current channel (If channel) inhibitor which has a specific bradycardiac effect, and it is under development for the treatment of stable angina and atrial fibrillation. Synonyms: N-[2-[(3R)-3-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)piperidin-1-yl]ethyl]-4-fluorobenzamide; YM 758; YM-758; YM758 cpd. CAS No. 312752-85-5. Molecular formula: C26H32FN3O4. Mole weight: 469.55. | |
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