Carboxylase Suppliers USA
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Product | Description | |
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Phosphoenolpyruvate carboxylase Quick inquiry Where to buy Suppliers range | Phosphoenolpyruvate carboxylase. Uses: Used for research and manufacturing. Group: Food Ingredients. Alternative Names: Phosphoenolpyruvic carboxylase;Phosphopyruvate carboxylase;Phosphoenol pyruvate carboxylase from maize;Phosphoenolpyruvate Carboxylase from maize leaves;Phospho(enol)pyruvate Carboxylase from Escherichia coli;Phosphoenolpyruvate carboxylase microbial;Phosphoenolpyruvate (PEP);Phosphoebolpyruvate Carboxylase. CAS No. 9067-77-0. Pack Sizes: 1 kg. Product ID: CDF4-0050. | |
1-(5-Amino-2-hydroxyphenyl)ethanone Quick inquiry Where to buy Suppliers range | 1-(5-Amino-2-hydroxyphenyl)ethanone is used in the preparation of alkylated flavonoid compounds for use as therapeutic antioxidants. It is also used to synthesize spiro[chromanone-piperidine]s as acetyl-CoA carboxylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 50-80-6. Pack Sizes: 50mg, 100mg. Molecular Formula: C8H9NO2, Molecular Weight: 151.16. US Biological Life Sciences. | Worldwide |
1-Bromo-2-methyl-4- (trifluoromethoxy) benzene Quick inquiry Where to buy Suppliers range | 1-Bromo-2-methyl-4- (trifluoromethoxy) benzene is used to prepare acetyl-CoA carboxylase inhibitors for metabolic syndrome treatment. Group: Biochemicals. Grades: Highly Purified. CAS No. 261951-96-6. Pack Sizes: 250mg, 1g. Molecular Formula: C8H6BrF3O, Molecular Weight: 255.03. US Biological Life Sciences. | Worldwide |
1-Hydroxycyclopropane carboxylic Acid Phosphate, Biscyclohexylamine Salt Quick inquiry Where to buy Suppliers range | A potent reversible inhibitor of enzymes utilizing phosphoenolpyruvate (PEP), such as phosphoenolpyruvate carboxylase which catalyzes the carboxylation of PEP to give oxaloacetate. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
2'- (1, 1-Dimethylethyl) -2', 6'-dihydro-1- (1H-indazol-5-ylcarbonyl) spiro[piperidine-4, 5' (7'H) -pyrano[3, 2-c]pyrazol]-7'-one Quick inquiry Where to buy Suppliers range | 2'- (1, 1-Dimethylethyl) -2', 6'-dihydro-1- (1H-indazol-5-ylcarbonyl) spiro[piperidine-4, 5' (7'H) -pyrano[3, 2-c]pyrazol]-7'-one is a dual inhibitor of acetyl-CoA carboxylase 1 and 2 (ACC1 and ACC2). Group: Biochemicals. Grades: Highly Purified. CAS No. 1197815-64-7. Pack Sizes: 5mg, 50mg. Molecular Formula: C22H25N5O3, Molecular Weight: 407.47. US Biological Life Sciences. | Worldwide |
2,2'-[1,4-Phenylenebis(oxy)]bis-propanoic Acid Dimethyl Ester Quick inquiry Where to buy Suppliers range | 2,2'-[1,4-Phenylenebis(oxy)]bis-propanoic Acid Dimethyl Ester is an intermediate in the synthesis of (±)-Fluazifop (F407430). (±)-Fluazifop is a grass-selective herbicide which inhibits acetyl-CoA carboxylase in sensitive plant species. Group: Biochemicals. Grades: Highly Purified. CAS No. 85977-51-1. Pack Sizes: 5mg, 10mg. Molecular Formula: C14H18O6. US Biological Life Sciences. | Worldwide |
2-?(4-?Hydroxyphenoxy-?2,?3,?5,?6-?d4)?-propanoic Acid Quick inquiry Where to buy Suppliers range | 2-?(4-?Hydroxyphenoxy-?2,?3,?5,?6-?d4)?-propanoic Acid is an intermediate in synthesizing (±)-Fluazifop-d4 (F407432), a labeled analogue of (±)-Fluazifop (F407430), which is a grass-selective herbicide which inhibits acetyl-CoA carboxylase in sensitive plant species. Group: Biochemicals. Grades: Highly Purified. CAS No. 127893-32-7. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C9H6D4O4, Molecular Weight: 186.2. US Biological Life Sciences. | Worldwide |
2-Fluoro-4-hydroxymethylphenol Quick inquiry Where to buy Suppliers range | 2-Fluoro-4-hydroxymethylphenol is used in preparation of fused imidazopyrimidinones that act as Lp-LPA2 inhibitors and also used to synthesize bicyclic inhibitors of acety-CoA carboxylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 96740-93-1. Pack Sizes: 100mg, 250mg. Molecular Formula: C7H7FO2, Molecular Weight: 142.13. US Biological Life Sciences. | Worldwide |
3-Methylcrotonyl glycine Quick inquiry Where to buy Suppliers range | 3-Methylcrotonyl glycine (3-MCG) is a metabolite found in the urine of patients with 3-methylcrotonyl glycinuria, a metabolic disorder characterized by a deficiency in 3-methylcrotonyl-CoA carboxylase, that has diverse biological activities. Synonyms: 3-MCG; β-Methylcrotonyl glycine; beta-Methylcrotonylglycine. Grades: ≥98%. CAS No. 33008-07-0. Molecular formula: C7H11NO3. Mole weight: 157.2. | |
ACC2 Inhibitor (N-(1-(2-(4-Isopropoxyphenoxy)-2,5-bithiazol-5-yl)ethyl)acetamide) Quick inquiry Where to buy Suppliers range | Cell-permeable. A potent and selective inhibitor of ACC2 (Acetyl-CoA Carboxylase) (IC50 = 28nM for hACC2 vs 210nM for hACC1 in in vitro studies). Group: Biochemicals. Alternative Names: N-(1-(2-(4-Isopropoxyphenoxy)-2,5-bithiazol-5-yl)ethyl)acetamide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
AMPK activator Quick inquiry Where to buy Suppliers range | AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand. D942 is thought to activate AMPK by inhibiting mitochondrial complex I, producing an increase in AMP levels. AMPK activator stimulates glucose uptake in L6 myocytes and promotes phosphorylation of acetyl-CoA carboxylase, which shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 μM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Because of the favorable physiological outcomes of AMPK activation on metabolism, AMPK has been considered to be an important therapeutic target for controlling human diseases including metabolic syndrome and cancer. Synonyms: D942; AMPK activator; 5-[3-[4-[2- (4-Fluorophenyl) ethoxy]phenyl]propyl]furan-2-carboxylic Acid. Grades: ≥95%. CAS No. 849727-81-7. Molecular formula: C22H21FO4. Mole weight: 368.4. | |
AMPK Signaling Agonist, F17 (4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~0.1uM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-a1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25uM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C. Group: Biochemicals. Grades: Highly Purified. CAS No. 280112-24-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Azo Coenzyme A Triammonium salt Quick inquiry Where to buy Suppliers range | Azo Coenzyme A Triammonium Salt, a fundamental biochemical reagent, holds momentous implications in exploring enzymatic reactions that involve coenzyme A and its various derivatives. This reagent remarkably aids in the synthesis of inhibitors for the acetyl-CoA carboxylase enzyme, which is crucial for fatty acid synthesis. The said reagent has also been scrutinized for its potential applications in treating metabolic disorders, hyperlipidemia and other related conditions, thereby signifying relatively consequential implications in the field of life sciences. Synonyms: (E)-4-(4-((4-butylphenyl)diazenyl)phenyl)butanoyl Coenzyme A (ammonium salt); 9H-Purin-6-amine, 9- [ (2ξ ) -5-O- [ [ [ [ (3R) -4- [ [3- [ [2- [ [4- [4- [ (E) -2- (4-butylphenyl) diazenyl] phenyl] -1-oxobutyl] thio] ethyl] amino] -3-oxopropyl] amino] -3-hydroxy-2, 2-dimethyl-4-oxobutoxy] hydroxyphosphinyl] oxy] hydroxyphosphinyl] -3-O-phosphono-β -D-threo-pentofuranosyl] -, ammonium salt; Coenzyme A, S-[4-[ (1E) -2- (4-Butylphenyl) diazenyl]benzenebutanoate], ammonium salt. Grades: >99%. CAS No. 2260670-58-2. Molecular formula: C41H67N12O17P3S. Mole weight: 1125.03. | |
Berberine chloride hydrate Quick inquiry Where to buy Suppliers range | The plant-based alkaloid berberine has potential therapeutic applications for breast cancer, although a better understanding of the genes and cellular pathways regulated by this compound is needed to define the mechanism of its action in cancer treatment. In this review, the molecular targets of berberine in various cancers, particularly breast cancer, are discussed. Berberine was shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells. Some signaling pathways affected by berberine, including the MAP (mitogen-activated protein) kinase and Wnt/β-catenin pathways, are critical for reducing cellular migration and sensitivity to various growth factors. Treatment with BBR(Berberine) in rats on the atherogenic diet reduced plasma total cholesterol and nonHDL cholesterol levels by 29%-33% and 31%-41%, respectively, with no significant differences being observed among the three doses. Berberine induced both apoptotic and autophagic death of HepG2 cells, which was associated with a significant activation of AMPK and an increased expression of the inactive form of acetyl-CoA carboxylase (ACC). Berberine did not show major effects on viability of HEK-293 embryonic kidney and HCT116 colon carcinoma cells and was not toxic in concentrations up to 20 μM. Berberine inhibited β-catenin transcriptional activity and attenuated anchorage-independent growth. As a result of berberine treatment, cellular levels of active β-catenin were reduced concomitant with an increase in the expression of E-cadherin. Synonyms: Natural Yellow 18. Grades: >98%. CAS No. 141433-60-5. Molecular formula: C20H18ClNO4. Mole weight: 371.81. | |
Chlorothricin Quick inquiry Where to buy Suppliers range | Chlorothricin is produced by the strain of Streptomyces antibioticus Tu 99. Related to kijanimicin, saccharocarcins, tetrocarcins and versipelostatin. It inhibits cholesterol biosynthesis from mevalonate, and inhibits pyruvate carboxylases purified from rat liver, chicken liver and azotobacter vinelandii. Synonyms: (4S, 4aS, 6aR, 11E, 12aR, 15R, 16aS, 21aR, 21bR)-4-[[4-O-[3-O-(3-Chloro-6-methoxy-2-methylbenzoyl)-2, 6-dideoxy-β-D-arabino-hexopyranosyl]-2, 6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1, 2, 3, 4, 4a, 6a, 7, 8, 9, 10, 12a, 15, 16, 21, 21a, 21b-hexadecahydro-22-hydroxy-15, 21a-dimethyl-18, 21-dioxo-18H-16a, 19-metheno-16aH-benzo[e]naphtho[2, 1-m][1, 4]dioxacyclopentadecin-14-carboxylic Acid; [4S-(4R*, 4aR*, 6aS*, 11E, 12aS*, 15S*, 16aR*, 21aS*, 21bS*)]-4-[[4-O-[3-O-(3-Chloro-6-methoxy-2-methylbenzoyl)-2, 6-dideoxy-β-D-arabino-hexopyranosyl]-2, 6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1, 2, 3, 4, 4a, 6a, 7, 8, 9, 10, 12a, 15, 16, 21, 21a, 21b-hexadecahydro-22-hydroxy-15, 21a-dimethyl-18, 21-dioxo-18H-16a, 19-metheno-16aH-benzo[e]naphtho[2, 1-m][1, 4]dioxacyclopentadecin-14-carboxylic Acid. Grades: >99% by HPLC. CAS No. 34707-92-1. Molecular formula: C50H63ClO16. Mole weight: 955.48. | |
Chlorothricin (Antibiotic K 818A) Quick inquiry Where to buy Suppliers range | The tetronic acid, chlorothricin is an unusual macrocyclic antibiotic from a Streptomyces sp. It shows inhibitory activity against cholesterol biosynthesis from mevalonate and inhibits pyruvate carboxylases purified from rat liver, chicken liver and Azotobacter vinelandii. Group: Biochemicals. Alternative Names: Antibiotic K 818A. Grades: Highly Purified. CAS No. 34707-92-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
CP640186 HCl Quick inquiry Where to buy Suppliers range | CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431. Synonyms: CP640186; CP 640186. Grades: 0.98. CAS No. 591778-70-0. Molecular formula: C30H36ClN3O3. Mole weight: 522.09. | |
D-Ribulose-1,5-diphosphate sodium salt hydrate Quick inquiry Where to buy Suppliers range | D-Ribulose-1,5-diphosphate sodium salt hydrate is a compound used in research purposes to study the enzyme, Ribulose bisphosphate carboxylase (Rubisco), which is responsible for catalyzing the first step in the photosynthetic carbon reduction cycle. It is also used in the discovery and development of drugs to treat diseases related to photosynthesis. Synonyms: RuDP; Sodium 1,5-di-O-phosphono-D-ribofuranose. CAS No. 14689-84-0. Molecular formula: C5H12O11P2. Mole weight: 310.09. | |
Lipid Metabolism Compound Library Quick inquiry Where to buy Suppliers range | A unique collection of 496 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS). - Covers several important targets, key components in lipid metabolism pathway, such as Acetyl-CoA Carboxylase?Acyltransferase?cholesteryl ester transfer protein (CETP)?FAAH?Fatty Acid Synthase (FASN)?HMG-CoA Reductase (HMGCR), etc. - Detailed compound information with structure, target, and biological activity description. - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2510. Categories: Lipid Metabolism Compounds Libraries. | |
N-Boc-L-glutamic Acid α-Benzyl Ester Quick inquiry Where to buy Suppliers range | N-Boc-L-glutamic Acid α-Benzyl Ester is an effective substrate for vitamin K-dependent carboxylase. N-Boc-L-glutamic Acid α-Benzyl Ester is a monopeptide used to study the interaction of nucleic acid bases with peptides. Group: Biochemicals. Alternative Names: N-[ (1, 1-Dimethylethoxy) carbonyl]-L-glutamic Acid 1-(Phenylmethyl) Ester; N-tert-Butoxycarbonyl-L-glutamic Acid α-Benzyl Ester; N-tert-Butoxycarbonylglutamic Acid α-Benzyl Ester. Grades: Highly Purified. CAS No. 30924-93-7. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
ND-630 Quick inquiry Where to buy Suppliers range | ND-630, also called as NDI 010976, is a highly selective, reversible inhibitor of acetyl-CoA carboxylase (ACC) and had IC50 values of 2 and 7 nM for ACC1 and 2, respectively, EC50 values in HepG2 serum free and 10% serum of 9 and 66 nM, respectively, and 2-fold C2C12 fatty acid oxidation (FAOxn) stimulation at 200 nM. Uses: Enzyme inhibitors. Synonyms: ND 630; ND630; NDI-010976; NDI 010976; NDI010976; GS-0976; GS0976; GS 0976; Firsocostat; Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo-; 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid; (R)-2-(1-(2-(2-Methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid; 2-[1-{(2R)-2-(2-methoxyphenyl)-2-[(oxan-4-yl)oxy]ethyl}-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl]-2-methylpropanoic acid; GS-ACC; GS-Y. Grades: ≥95%. CAS No. 1434635-54-7. Molecular formula: C28H31N3O8S. Mole weight: 569.63. | |
ND-630 S enantiomer Quick inquiry Where to buy Suppliers range | ND-630 S enantiomer is the S enantiomer of ND-630 which is an acetyl-CoA carboxylase (ACC) inhibitor, and improves metabolic syndrome endpoints, decreases liver steatosis, decreases expression of inflammatory markers and improves fibrosis. Synonyms: 2-[1-[(2S)-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid; ND-630 (S enantiomer); ND 630 (S enantiomer); ND630 (S enantiomer). Molecular formula: C28H31N3O8S. Mole weight: 569.63. | |
ND-646 Quick inquiry Where to buy Suppliers range | ND-646 is an orally bioactive inhibitor of acetyl-CoA carboxylase (ACC) that inhibits both ACC1 and ACC2. It prevents ACC subunit dimerization to inhibit fatty acid synthesis in vitro and in vivo. Synonyms: ND 646; ND646; BCP29105; CS-7887; BCP 29105; CS 7887; BCP-29105; CS7887; Thieno[2,3-d]pyrimidine-3(2H)-acetamide, 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo-; 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetamide; (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanamide. Grades: ≥95%. CAS No. 1434639-57-2. Molecular formula: C28H32N4O7S. Mole weight: 568.64. | |
Olumacostat glasaretil Quick inquiry Where to buy Suppliers range | OG (Olumacostat glasaretil) is a acetyl-coenzyme A carboxylase inhibitor. Acetyl-COA carboxylase is the key point for the first, rate-limiting step in de novo fatty acid synthesis. OG can inhibit in vitro human sebocyte lipid production, it can also reduce in vivo sebaceous gland size in hamster ears. Synonyms: Olumacostat glasaretil; DRM01B; DRM-01B; DRM 01B. 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyl 5-(tetradecyloxy)furan-2-carboxylate. Grades: 98%. CAS No. 1261491-89-7. Molecular formula: C26H43NO7. Mole weight: 481.63. | |
Oxalacetic Acid (Oxaloacetic acid) Quick inquiry Where to buy Suppliers range | A four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase. Oxaloacetic acid, in the form of its conjugate base oxaloacetate, is a metabolic intermediate in many processes that occur in animals. It takes part in the: gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, fatty acid synthesis and citric acid cycle. Gluconeogenesis[1] is a metabolic pathway consisting of a series of eleven enzyme-catalyzed reactions, resulting in the generation of glucose from non-carbohydrates substrates. The beginning of this process takes place in the mitochondrial matrix, where pyruvate molecules are found. A pyruvate molecule is carboxylated by a pyruvate carboxylase enzyme, activated by a molecule each of ATP and water. This reaction results in the formation of oxaloacetate. NADH reduces oxaloacetate to malate. This transformation is needed to transport the molecule out of the mitochondria. On Group: Biochemicals. Alternative Names: Oxobutanedioic Acid; Oxalacetic Acid; 2-Ketosuccinic acid; 2-Oxobutanedioic acid; 2-Oxosuccinic Acid; Ketosuccinic Acid; NSC 284205; NSC 77688; OAA; Oxaloacetic Acid; Oxaloethanoic Acid; Oxosuccinic Acid; α-Ketosuccinic Acid. Grades: Reagent Grade. CAS No. 328-42-7. Pack Sizes: 25g, 50g, 100g, 250g. Molecular Formula: C?H?O?, Molecular Weight: 132.07. US Biological Life Sciences. | Worldwide |
PF 05175157 Quick inquiry Where to buy Suppliers range | PF-05175157 is a selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 and isoform ACC2 dominant. IC50 values are 27 nM and 33 nM, respectively. It was originated by Pfizer. ACC inihibitors can inhibit de novo lipogenesis and increase β-oxidation of long-chain fatty acids. In Feb 2015, Phase-II for Type-2 diabetes mellitus in USA was discontinued. Uses: Type 2 diabetes mellitus. Synonyms: PF-05175157; PF05175157; 1,4-Dihydro-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one. Grades: 98%. CAS No. 1301214-47-0. Molecular formula: C23H27N5O2. Mole weight: 405.50. | |
Potassium Pyruvate Quick inquiry Where to buy Suppliers range | Pyruvic Acid Potassium Salt is an intermdiate in sugar metabolism and enzymatic carbohydrate degredation. It is converted by carboxylase into acetaldehyde and CO2. In muscle, it is reduced to lactic acid during exertion, then reoxidized and partly retransformed to glycogen upon resting. When present in culture medium, it improves coliform recovery. It has been shown to be involved in a mitochondrial oxidant-activated metabolic regulatory pathway. It has also been shown to be involved in plant respiratory regulation. Group: Biochemicals. Alternative Names: Pyruvic Acid Potassium Salt. Grades: Highly Purified. CAS No. 4151-33-1. Pack Sizes: 50g, 100g, 250g, 500g. Molecular Formula: C3H3KO3, Molecular Weight: 126.15. US Biological Life Sciences. | Worldwide |
Propionyl coenzyme A lithium salt Quick inquiry Where to buy Suppliers range | Propionyl coenzyme A lithium salt is a crucial compound used in biomedical field for its involvement in numerous biochemical processes. This product plays a vital role in energy metabolism as a cofactor, facilitating the conversion of propionic acid into succinyl coenzyme A. It is particularly valuable in studying diseases related to propionyl-CoA carboxylase deficiency. Synonyms: N-Propionyl coenzyme a lithium salt; lithium [ (2R, 3S, 4R, 5R) -5- (6-aminopurin-9-yl) -4-hydroxy-2- [ [hydroxy- [hydroxy- [3-hydroxy-2, 2-dimethyl-4-oxo-4- [ [3-oxo-3- (2-propanoylsulfanylethylamino) propyl] amino] butoxy] phosphoryl] oxyphosphoryl] oxymethyl] oxolan-3-yl] hydrogen phosphate. Grades: ≥ 90%. CAS No. 108321-21-7. Molecular formula: C24H39LiN7O17P3S. Mole weight: 829.53. | |
PT 1 Quick inquiry Where to buy Suppliers range | PT 1 is an AMPK (AMP-activated protein kinase) activator that stimulates AMPK heterotrimer (α1β1γ1) activity (EC50=0.3 μM). PT1 dose-dependently increases phosphorylation of AMPK and its downstream substrate, acetyl-CoA carboxylase, without increasing the cellular AMP:ATP ratio in L6 myotubes. It stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes. Synonyms: PT 1; PT1; PT-1; 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid. Grades: ≥98% by HPLC. CAS No. 331002-70-1. Molecular formula: C23H16ClN3O6S. Mole weight: 497.91. | |
RSVA 405 Quick inquiry Where to buy Suppliers range | RSVA 405, an analog of resveratol, can significantly activate AMPK (EC50 = 1 μM) and inhibit acetyl-CoA carboxylase (ACC), one target of AMPK and a key regulator of fatty acid biogenesis, in nondifferentiated and proliferating 3T3-L1 adipocytes. It activates AMPK indirectly through a CaMKKβ-dependent mechanism. Synonyms: 2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid; RSVA405; RSVA 405; RSVA-405. Grades: ≥98% by HPLC. CAS No. 140405-36-3. Molecular formula: C17H20N4O2. Mole weight: 312.37. | |
(S)-(+)-α-Fluoromethylhistidine Dihydrochloride Quick inquiry Where to buy Suppliers range | A histidine carboxylase inhibitor. Group: Biochemicals. Alternative Names: α-Fluoromethylhistidine Dihydrochloride; α-(Fluoromethyl)-L-histidine Dihydrochloride. Grades: Highly Purified. Pack Sizes: 500ug. Molecular Formula: C?H??Cl?FN?O?, Molecular Weight: 260.09. US Biological Life Sciences. | Worldwide |
SAMS Quick inquiry Where to buy Suppliers range | SAMS peptide, a synthetic peptide substrate for AMPK based on the sequence around Ser79 on acetyl-CoA carboxylase, is more selective for the kinase than acetyl CoA carboxylase itself, and provides a convenient and sensitive assay for AMPK. Synonyms: (Ser76, Arg86.87)-ACC-α (73-87) (dephosphorylated) (E.coli, rat); (Ser76, Arg86.87)-Acetyl-CoA Carboxylase 1 (73-87) (dephosphorylated) (E.coli, rat); (Ser77, Arg87.88)-ACC-α (74-88) (dephosphorylated) (bovine, ovine); (Ser77, Arg87.88)-Acetyl-CoA Carboxyla; H-His-Met-Arg-Ser-Ala-Met-Ser-Gly-Leu-His-Leu-Val-Lys-Arg-Arg-OH; L-histidyl-L-methionyl-L-arginyl-L-seryl-L-alanyl-L-methionyl-L-seryl-glycyl-L-leucyl-L-histidyl-L-leucyl-L-valyl-L-lysyl-L-arginyl-L-arginine. Grades: >95%. CAS No. 125911-68-4. Molecular formula: C74H131N29O18S2. Mole weight: 1779.15. | |
Sodium Pyruvate (Pyruvic Acid Sodium Salt) Quick inquiry Where to buy Suppliers range | Intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination. A diagnostic agent for Parkinson disease. Used in culture broth and media as an energy source for propagating cells. Group: Biochemicals. Alternative Names: 2-Oxopropanoic Acid Sodium Salt; Sodium Pyruvate; Sodium α-Ketopropionate. Grades: Cell Culture Grade. CAS No. 113-24-6. Pack Sizes: 100g, 500g, 1Kg, 2.5Kg. Molecular Formula: C3H3O3Na, Molecular Weight: 110. US Biological Life Sciences. | Worldwide |
Stevioside hydrate (BRN 0077427, CCRIS 6116) Quick inquiry Where to buy Suppliers range | Noncaloric natural sweetener, 300 times more potent than sucrose. Antidiabetic. Antihyperglycaemic and antihypoglycaemic. Potentiates insulin secretion. Enhances acetyl-CoA carboxylase (ACC) gene expression. Increases insulin sensitivity. Antihypertensive. Ca2+ influx inhibitor. Anticancer compound. Chemopreventive. Anti-inflammatory. IKKbeta, NF-kappaB and MAPK signaling inhibitor. Induces TNF-alpha, IL-1beta and nitric oxide release. Immunomodulator. Increasees phagocytic activity, haemagglutination antibody titre, delayed type hypersensitivity. Increased proliferation in LPS and Con A stimulated B and T cells. Peripheral me-opioid receptors activator. Important for regulation of glucose homeostasis. Anti-atherosclerotic. Group: Biochemicals. Alternative Names: BRN 0077427, CCRIS 6116. Grades: Highly Purified. CAS No. 57817-89-7 (anhy). Pack Sizes: 10mg, 50mg. Molecular Formula: C38H60O18. xH2O. US Biological Life Sciences. | Worldwide |
TOFA Quick inquiry Where to buy Suppliers range | TOFA is a cell-permeable, potent, reversible, and competitive allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). It inhibits the fatty acid biosynthesis by blocking the synthesis of malonyl-CoA. Uses: Hypolipidemic agents. Synonyms: 5-tetradecoxyfuran-2-carboxylic acid; 5-(tetradecyloxy)-2-furancarboxylic acid; 5-(tetradecyloxy)-2-furoic acid; RMI 14514; RMI-14514. CAS No. 54857-86-2. Molecular formula: C19H32O4. Mole weight: 324.45. |