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| Product | Description | |
|---|---|---|
| Cartilage, Nasal, Bovine | Cartilage, Nasal, Bovine. Group: Biologicals. Grades: Purified. Pack Sizes: 100g. US Biological Life Sciences. |  Worldwide |
| Collagen Type II, Bovine Sternal Cartilage, Collagen Dillution Buffer (10X) | Collagen Type II, Bovine Sternal Cartilage, Collagen Dillution Buffer (10X). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 1x10ml. US Biological Life Sciences. | Worldwide |
| Collagen Type II, Chick Sternal Cartilage, Dilution Buffer, 10X | Collagen Type II, Chick Sternal Cartilage, Dilution Buffer, 10X. Group: Molecular Biology. Pack Sizes: 10ml. US Biological Life Sciences. | Worldwide |
| Collagen Type II, Human Sternal Cartilage, Dilution Buffer (10X) | Collagen is an inert, rigid protein found predominantly in skin, ligaments, bones and teeth. Its most distinctive attribute, essential to a transmitter of mechanical force, is inelasticity. Its fundamental structural unit is tropo-collagen, a molecular rod about 2600Å in length and 15Å in diameter and 300,000 molecular weight. In tendons these macromolecules, grouped as collagen fibrils, run parallel to the axis. In skin the fibrils are interlaced and branched. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 10ml. US Biological Life Sciences. | Worldwide |
| Collagen Type II, Porcine Sternal Cartilage, Dilution Buffer (10X) | Collagen Type II, Porcine Sternal Cartilage, Dilution Buffer (10X). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 1x10ml. US Biological Life Sciences. | Worldwide |
| Collagen Type II, Rat Sternal Cartilage, Dilution Buffer (10x) | Collagen Type II, Rat Sternal Cartilage, Dilution Buffer (10x). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 1x10ml. US Biological Life Sciences. | Worldwide |
| Shark Cartilage Powder | Shark Cartilage Powder. |  CA, FL & NJ |
| 2-Amino-2-deoxy-3,4-di-O-methyl-D-glucose | 2-Amino-2-deoxy-3,4-di-O-methyl-D-glucose, a synthetic glucose derivative, serves as a valuable research tool in the biomedical industry to investigate glucose transportation and metabolism. With its potential to examine the effects of glucosamine on cartilage metabolism and as a potential treatment for osteoarthritis, it has garnered attention in scientific studies. This molecule's intricate structure and capacity for modulating fundamental biological processes makes it a key subject of investigation in the field of biomedical research. Synonyms: 3,4-Di-O-methyl-D-glucosamine. CAS No. 25521-10-2. Molecular formula: C8H17NO5. Mole weight: 207.22. |  |
| ADAMTS-4 endopeptidase | In peptidase family M12. Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix. Group: Enzymes. Synonyms: aggrecanase-1. Enzyme Commission Number: EC 3.4.24.82. CAS No. 147172-61-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4366; ADAMTS-4 endopeptidase; EC 3.4.24.82; 147172-61-0; aggrecanase-1. Cat No: EXWM-4366. |  |
| ADAMTS-5 inhibitor | ADAMTS-5 (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 5) is an aggrecanase-2. ADAMTS-5 is involved in the catabolism of aggrecan and collagen in the articular cartilage matrix during Osteoarthritis (OA). Synonyms: ADAMTS-5 Inhibitor; ADAMTS 5 Inhibitor; ADAMTS5 Inhibitor; 5-[[5-[(4-chlorophenyl)methylsulfanyl]-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one. Grades: 99%. CAS No. 929634-33-3. Molecular formula: C16H11ClF3N3OS3. Mole weight: 449.92. | |
| Cathepsin Inhibitor 1 | Osteoarthritis is currently recognized as a chronic degenerative disease, which is caused by the loss of articular cartilage and damage to underlying bone, resulting in joint instability and pain. Cathepsin Inhibitor 1 is an inhibitor of Cathepsin. The IC50s for Cathepsin L, L2, S, K, B are 7.9, 6.7, 6.0, 5.5 and 5.2 nM, respectively. Synonyms: Cathepsin-Inhibitor-1; CTS-IN-1; CTS IN 1. Grades: ≥98%. CAS No. 225120-65-0. Molecular formula: C20H24ClN5O2. Mole weight: 401.89. | |
| Chitobiose octaacetate | Chitobiose octaacetate, a carbohydrate derivative, is a promising candidate for the treatment of osteoarthritis. Studies demonstrate that it inhibits cartilage-degrading enzymes, the primary culprits of joint degradation in the disease. Furthermore, it attenuates inflammation and pain associated with osteoarthritis. Experts are currently examining its potential as a therapeutic agent, while the manifold intricacies of its pharmacological workings prompt ongoing investigation. Synonyms: 2-acetamido-4-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-alpha-D-glucose 1,3,3',4',6,6'-hexaacetate; 1-O,3-O,6-O-Triacetyl-4-O-[3-O,4-O,6-O-triacetyl-2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-2-(acetylamino)-2-deoxy-α-D-glucopyranose; N,N'-Diacetylchitobiose hexaacetate; α-D-Glucopyranose, 2-(acetylamino)-2-deoxy-4-O-[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-, 1,3,6-triacetate; octaacetylchitobiose. Grades: ≥95%. CAS No. 7284-18-6. Molecular formula: C28H40N2O17. Mole weight: 676.62. | |
| Chondroitin disaccharide Δdi-disE | Chondroitin disaccharide Δdi-disE: A biomedical product used in the treatment of joint-related conditions. Derived from chondroitin, it aids in repairing and maintaining healthy cartilage. With its anti-inflammatory properties, it alleviates pain caused by arthritis and supports improved joint mobility. CAS No. 1990-26-0. Molecular formula: C14H18NNa3O17S2. Mole weight: 605.39. | |
| Chondroitin disaccharide Δdi-triS | Chondroitin disaccharide Δdi-triS is a crucial component in the biomedical industry, specifically used in the research of joint-related conditions such as osteoarthritis. Its presence assists in maintaining the integrity and flexibility of cartilage. Molecular formula: C14H17NNa4O20S3. Mole weight: 707.44. | |
| Chondroitin disaccharide di-6S | Chondroitin disaccharide di-6S is a crucial component in the biomedical industry, commonly used in the development of treatments for various joint-related disorders. It plays a vital role in treating osteoarthritis, reducing pain and inflammation as well as facilitating the regeneration of damaged cartilage. Synonyms: Disodium; (2S,3S,4S,5R,6R)-6-[(3R,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-(sulfonatooxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate; Chondroitin disaccharide di-6S disodium salt. CAS No. 149458-08-2. Molecular formula: C14H21NNa2O15S. Mole weight: 521.36. | |
| Chondroitine sulfate | Chondroitin sulfate can be found in the Shark cartilage. Chondroitin is in dietary supplements used as an alternative medicine to treat osteoarthritis and also approved and regulated as a symptomatic slow-acting drug for this disease (SYSADOA) in Europe and some other countries. The hydrolysis and transglycosylation reactions of bovine testicular hyaluronidase were dose-dependently inhibited by Chondroitin sulfate oligosaccharides. Uses: Antihyperlipemic. Synonyms: poly-1(2/3)-n-acetyl-2-amino-2-deoxy-3-o-beta-d-glucopyranurosyl-4-(6)sulfonyl-d-galactose; chondroitinpolysulfate; chondroitinsulfates; chondroitinsulfuricacid; chondroitinsulfuricacids; chonsurid; CHONDROITIN SULPHATE; CHONDROITINE SULPHATE. Grades: >90%. CAS No. 9007-28-7. Molecular formula: (C14H21NO14S)n. Mole weight: 463.37. | |
| Chondroitin sulfate C sodium salt | Chondroitin sulfate C sodium salt is a compound used in the research of joint disorders and osteoarthritis. It acts as a cartilage-building compound aiding in repair and regeneration. This compound is derived from sources such as fish or bovine cartilage. Synonyms: Chondroitin 6-sulfate sodium salt. CAS No. 12678-07-8. Molecular formula: (C14H19NO14SNa2)n. Mole weight: 1390.1. | |
| Chondroitin Sulfate (dp10) | Chondroitin Sulfate (dp10), a key player in the biomedical industry, works wonders as a supplement that eases joint pain and stiffness while taking the center stage in tackling the widespread problem of osteoarthritis that plagues the older population. This essential constituent bolsters cartilage health, augmenting joint functionality, and mitigating pain stemming from the wear and tear of daily use. With its anti-inflammatory characteristics, it serves as a valuable asset in addressing a range of inflammatory maladies. Synonyms: Chondroitin Sulphate Oligosaccharide dp10. | |
| Chondroitin Sulfate (dp12) | Chondroitin sulfate (dp12) - a compound that has exhibited enormous therapeutic potential against joint pain and osteoarthritis. Its utility stems from its crucial role in maintaining and regenerating cartilage and reducing inflammation. Supplementary intake has been linked to improved viscosity of synovial fluid, aiding the recuperation of cartilage structure. Synonyms: Chondroitin Sulphate Oligosaccharide dp12. | |
| Chondroitin Sulfate (dp14) | Chondroitin Sulfate(dp14), a prevailing compound observed naturally in the connective tissues including cartilage and bone, can be used as a dietary supplement to relieve osteoarthritis and joint pain. Furthermore, the studies strongly indicate the likelihood of its effectiveness in augmenting joint functionality whilst diminishing inflammation. Synonyms: Chondroitin Sulphate Oligosaccharide dp14. | |
| Chondroitin Sulfate (dp16) | Chondroitin Sulfate (dp16), a glycosaminoglycan abundant in cartilage and connective tissues, boasts anti-inflammatory effects that mitigate osteoarthritis symptoms. Furthermore, it serves as an integral component of regenerative medicine by enhancing cell proliferation and promoting tissue regeneration. Beyond its osteoarthritis applications, Chondroitin Sulfate (dp16) also exhibits tremendous therapeutic potential for combating cardiovascular diseases, cancer, and diabetes. Thus, the significant biological and pharmacological functions of Chondroitin Sulfate (dp16) warrant further investigation to fully exploit its manifold benefits. Synonyms: Chondroitin Sulphate Oligosaccharide dp16. | |
| Chondroitin Sulfate (dp18) | Chondroitin Sulfate (dp18), a naturally occurring compound in cartilage, has been hailed for its therapeutic value in the treatment of osteoarthritis and joint pain. While studies have shown its potential in combating inflammation and bolstering joint health, this product has also found use as a preventative measure against further damage. With its multifaceted benefits, Chondroitin Sulfate (dp18) provides a promising solution for those seeking to support healthy joints. Synonyms: Chondroitin Sulphate Oligosaccharide dp18. | |
| Chondroitin Sulfate (dp4) | Chondroitin Sulfate (dp4), a constituent of cartilage matrix, has gained attention as a supplement for joint health. It exhibits remarkable potential in quelling joint pain and easing inflammation, particularly concerning osteoarthritis. By extension, its potent anti-inflammatory attributes hold promise for treating autoimmune disorders, including multiple sclerosis. Synonyms: Chondroitin Sulphate Oligosaccharide dp4. | |
| Chondroitin Sulfate (dp6) | Chondroitin Sulfate (dp6) is a paramount compound in the realm of osteoarthritand joint disorders,functioning as an indomitable structural compound within cartilage. It effectively nurtures cartilage development while staunchly impeding its erosion. Synonyms: Chondroitin Sulphate Oligosaccharide dp6. | |
| Chondroitin Sulfate (dp8) | Chondroitin Sulfate (dp8) is a compound used in the research of osteoarthritis, joint pain and cartilage degeneration known for its anti-inflammatory properties. Synonyms: Chondroitin Sulphate Oligosaccharide dp8. | |
| Chondroitin sulfate sodium salt | Chondroitin sulfate sodium salt is a sulfated glycosaminoglycan (GAG) and a component of cartilage. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: Sodium chondroitin sulfate; Sodium chondroitin polysulfate; Chondroitin polysulfate sodium. Grades: 98%. CAS No. 9082-7-9. | |
| Chondroitin sulphate hexasaccharide ammonium salt | Chondroitin sulphate hexasaccharide ammonium salt is a biomedical compound used for studying joint disorders, particularly osteoarthritand rheumatoid arthritis. Its anti-inflammatory effects and ability to promote cartilage regeneration make it an ideal component in pharmaceutical formulations targeting these conditions. Mole weight: 1488. | |
| Chondro peptide | Chondro peptide is produced from optimized chicken breast cartilage with unique technology. Good solubility, high hot acid stability, suitable for ordinary food, health food and functional food. Product ID: CDF4-0248. Category: Protein peptide. Product Keywords: Protein Peptides; Chondro peptide; CDF4-0248; Protein peptide;. Applications: It is widely used in food, cosmetics and medicine. Product Description: Chondro peptide has low molecular weight and is easy to absorb. Rich in chondroitin sulfate. |  |
| C-Type Natriuretic Peptide (CNP) (1-22), human | C-type natriuretic peptide is an endogenous peptide found in plasma and cerebrospinal fluid. It is composed of 22 amino acids. C-type natriuretic peptide acts as an agonist of natriuretic peptide receptor NPR2 (NPRB) and exhibits affinity for NPR3 (NPRC). It inhibits L-type calcium currents in myocytes and exhibits antiproliferative effects in cardiac fibroblasts in vitro. Regulates cartilage homeostasis, body fluid volume and exhibits vasodilatory activity in vivo. Synonyms: H-Gly-Leu-Ser-Lys-Gly-Cys(1)-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys(1)-OH; glycyl-L-leucyl-L-seryl-L-lysyl-glycyl-L-cysteinyl-L-phenylalanyl-glycyl-L-leucyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-glycyl-L-seryl-L-methionyl-L-seryl-glycyl-L-leucyl-glycyl-L-cysteine (6->22)-disulfide; Natriuretic peptide, C-type; C-type natriuretic peptide (1-22) (human, rat, swine); Atriopeptin C (pig); C-Type Natriuretic Peptide (32-53) (human, porcine, rat). Grades: ≥95%. CAS No. 127869-51-6. Molecular formula: C93H157N27O28S3. Mole weight: 2197.60. | |
| Cynaropicrin | Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κBsignaling. Group: Inhibitors. CAS No. 35730-78-0. Molecular formula: C19H22O6. Mole weight: 346.37. Purity: 0.97. Catalog: ACM35730780. |  |
| Cynaropicrin | Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor ( TNF-α ) release with IC 50 s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor ( MMP13 ) and suppresses NF-κB signaling. Uses: Scientific research. Group: Natural products. CAS No. 35730-78-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N2350. |  |
| Dermatan Sulfate (dp10) | Dermatan Sulfate (dp10), a polysaccharide with myriad biomedical applications, has captivated researchers as a therapeutic intervention for osteoarthritis, cancer, and other inflammatory diseases. Through its dynamic enzymatic capabilities, Dermatan Sulfate (dp10) has been identified as a formidable deterrent to cartilage decay, making it an attractive option for those seeking to mitigate the onset and progression of joint degeneration. Synonyms: Dermatan Sulphate Oligosaccharide dp10. Mole weight: 2480. | |
| Dermatan Sulfate (dp20) | Dermatan sulfate (dp20), the extracellular matrix component that participates in diverse physiological phenomena, exhibits novel potential in remedial contexts, such as improved wound healing and mitigated osteoarthritic progressions by fostering cartilage regeneration and moderating inflammation. Its aptitude to synergize with growth factors delineates its propitious candidacy for efficacious drug targeting and tissue engineering deployments. Synonyms: Dermatan Sulphate Oligosaccharide dp20. Mole weight: 4960. | |
| D-Glucosamine-6-phosphate sodium salt | D-Glucosamine-6-phosphate sodium salt is a significant constituent assuming a fundamental role as a precursor for the biogenesis of glycoproteins and glycosaminoglycans. These biomolecules are indispensable in ensuring the upkeep of robust cartilage and connective tissues. Its application primarily revolves around studying afflictions such as osteoarthritand various joint maladies. CAS No. 70442-23-8. Molecular formula: C6H12NNaO8P. Mole weight: 280.12. | |
| Docosanedioic acid | Behenic acid, or docosanedioic acid, a saturated fatty acid, is an effective emollient in the cosmetics industry due to its remarkable moisturizing properties. Behenic acid's therapeutic potential is another aspect of interest, as it has been researched for the treatment of various maladies, including multiple sclerosis and Parkinson's disease. Moreover, it is demonstrated to have a positive impact on chondrogenesis, which is vital for the formation of cartilage tissue due to its exceptional proliferative force. Synonyms: docosanedioicacid; Docosanedioicacid; Felogenicacid; Phellogenicacid; 1,22-Docosanedioicacid; 505-56-6. Grades: 95%. CAS No. 505-56-6. Molecular formula: C22H42O4. Mole weight: 370.57. | |
| Fructosamine hydrochloride | Fructosamine hydrochloride (D-Isoglucosamine hydrochloride) is a metabolic intermediate and component of cell membranes and cartilage. Fructosamine hydrochloride induces site-specific breaks in DNA chains, especially in the presence of Cu 2+ [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: D-Isoglucosamine hydrochloride. CAS No. 39002-30-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W414321. | |
| Fulvic Acid | Free radical scavenger and antioxidant. Potential compound to neutralize radioactive and toxic wastes and "heal" soils. Chelates and binds scores of minerals into a bioavailable form used by cells. Shown to incorporate into bone and cartilage of rats. Antibacterial. Antifungal. beta-Hexosaminidase release inhibitor. Anti-inflammatory. Tau fibrils aggregation inhibitor (Alzheimers Disease). Antiseptic. Interrupts the dimer formation of Abeta (17-42) peptides. Group: Biochemicals. Alternative Names: 4,10-dihydro-3,7,8-trihydroxy-3-methyl-10-oxo-1H,3H-pyrano[4,3-b][1]benzopyran-9-carboxylic acid. Grades: Highly Purified. CAS No. 479-66-3. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Gelatin methacryloyl | The polymer product is a polymer that is derived from natural sources, with or without chemical modification. Uses: Gelatin-methacrylate can be used to form crosslinked hydrogels for tissue engineering and 3d printing. it has been used for endothelial cell morphogenesis, cardiomyocytes, epidermal tissue, injectable tissue constructs, bone differentiation, and cartilage regeneration. gelatin-methacrylate has been explored in drug delivery applications in the form of microspheres and hydrogels. Group: Natural polymers and biopolymers. Alternative Names: GelMa, Gelatin Methacrylate, Gelatin methacrylamide. Mole weight: (C40H59N11O13)n. |  |
| Givinostat HCl | Givinostat or gavinostat, aslo known as ITF2357, is a potent and orally active histone deacetylase inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. It is a hydroxamate used in the form of its hydrochloride. Inhibition of HDAC activity by ITF2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis.ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro. ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro. Group: Inhibitors. Alternative Names: ITF2357; ITF-2357; ITF 2357; ITF2357 HCl; ITF2357 hydrochloride; Givinostat HCl. CAS No. 199657-29-9. Molecular formula: C24H28ClN3O4. Mole weight: 457.96. Appearance: Solid powder. Purity: >98%. IUPACName: (6-((diethylamino)methyl)naphthalen-2-yl)methyl (4- (hydroxycarbamoyl)phenyl)carbamate hydrochloride. Canonical SMILES: O=C (OCC1=CC=C2C=C (CN (CC)CC)C=CC2=C1)NC3=CC=C (C (NO)=O)C=C3. [H]Cl. Catalog: ACM199657299. | |
| Glucosamine | Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes [1]. Uses: Scientific research. Group: Natural products. Alternative Names: D-Glucosamine; Chitosamine. CAS No. 3416-24-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1125. | |
| Glucosamine hydrochloride | Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes [1]. Uses: Scientific research. Group: Natural products. Alternative Names: D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride. CAS No. 66-84-2. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-N0733. | |
| Glucosamine (hydrochloride) (Standard) | Glucosamine (hydrochloride) (Standard) is the analytical standard of Glucosamine (hydrochloride). This product is intended for research and analytical applications. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes [1]. Uses: Scientific research. Group: Natural products. CAS No. 66-84-2. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0733R. | |
| Glucosamine sulfate | Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes [1]. Uses: Scientific research. Group: Natural products. Alternative Names: D-Glucosamine sulfate. CAS No. 29031-19-4. Pack Sizes: 500 mg. Product ID: HY-N0487. | |
| Golimumab | Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: CNTO-148. CAS No. 476181-74-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99111. | |
| ICI 211965 | ICI 211965 is a selective 5-lipoxygenase inhibitor and it may be useful in regulating production of those interleukins involved in joint cartilage destruction. Synonyms: ICI 211965; ICI-211965; ICI211965; 1-(3-(Naphth-2-ylmethoxy)phenyl)-1-(thiazol-2-yl)propyl methyl ether. Grades: 98%. CAS No. 129424-08-4. Molecular formula: C24H23NO2S. Mole weight: 389.52. | |
| Kartogenin | Kartogenin (KGN) is an inducer of chondrogenic tissue formation ( EC 50 : 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KGN. CAS No. 4727-31-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16268. | |
| Kartogenin, CBF-beta Activator (2-(Biphenyl-4-ylcarbamoyl)benzoic Acid) | A cell-permeable biphenyl carbamoyl benzoate compound that potently induces the differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes (EC500nM). Reversibly binds to the FC-1 fragment of filamin A and disrupts its association with CBFB leading to nuclear localization of CBFB and binding to runt-related transcription factor (RUNX) to regulate chondrogenesis. Also reported to inhibit cytokine-induced release of nitric oxide (NO) and glycosaminoglycan (GAG). Exhibits chondroprotective properties and promotes cartilage repair in murine osteoarthritis models. Shown to up-regulate the levels of TIMP1, collagen, and aggrecan thereby blocking further matrix breaown without affecting the activities of MMP-3, MMP-13, and aggrecanase in primary chondrocytes or hMSCs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??NO?, Molecular Weight: 317.3. US Biological Life Sciences. | Worldwide |
| Kartogenin sodium | Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation ( EC 50 : 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KGN sodium. CAS No. 1401168-39-5. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-16268A. | |
| Matrix Metalloproteinase-3 from Human, Recombinant | Matrix metalloproteinase-3 (MMP-3) also known as stromelysin-1 and transin (EC 3.4.24.17) cleaves a number of substrates including cartilage proteoglycan, collagen types II, III, IV, V and IX, fibronectin, laminin, and can activate MMP 1. MMP-3 is secreted as 57 and 59 kDa proenzymes and can be activated in vitro by organomercurials (e.g., 4 aminophenylmercuric acetate, APMA) and in vivo by proteases via intermediate forms to a 45 kDa active MMP 3 enzyme. Further autolysis to a 28 kDa form can also occur. MMP-3 is thought to play an important role in pathophysiological degradation processes associated with conditions such as rheumatoid arthritis and cancer cell invas...C 3.4.24.17; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Enzyme Commission Number: EC 3.4.24.17. CAS No. 79955-99-0. Purity: >95% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 57 kDa. Storage: < -70°C; Avoid freeze/thaw. Form: Lyophilized from 100 mM NaCl, 50 mM HEPES, pH 7.3. Species: Human. Stromelysin 1; EC 3.4.24.17; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Cat No: NATE-0861. | |
| ML 120B dihydrochloride | ML 120B dihydrochloride is an ATP-competitive IKK2-selective inhibitor with IC50 value of 60 nM at 50 μM ATP. It can inhibit paw swelling, bone and cartilage degradation. Synonyms: ML 120B dihydrochloride; ML120B dihydrochloride; ML-120B dihydrochlorideN-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1782573-78-7. Molecular formula: C19H15ClN4O2.2HCl. Mole weight: 439.72. | |
| N-Propionyl-D-glucosamine | N-Propionyl-D-glucosamine, a highly significant biomedical substance, assumes an indispensable role in the treatment of joint-related afflictions while bolstering the well-being of cartilage. Its application conventionally encompasses the formulation of pharmacological agents and remedial approaches to address arthritis, osteoarthritis, and other inflammatory ailments that afflict the joints. Synonyms: N-Propionyl-D-glucosamine; 15475-14-6; N-((3R,4R,5S,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)propionamide; N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]propanamide; SCHEMBL15334407; RTEOJYOKWPEKKN-JOHDSVJWSA-N; MFCD00059803; AKOS000369741; AKOS027327732; AS-40587; W-201396. CAS No. 15475-14-6. Molecular formula: C9H17NO6. Mole weight: 235.23. | |
| Pamidronate disodium | Pamidronate disodium, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium can inhibit the signaling of Wnt and β-catenin , and is applicable for research on osteoporosis and osteosarcoma [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CGP 23339A. CAS No. 57248-88-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0012A. | |
| Pamidronic acid | Pamidronic acid, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid can inhibit the signaling of Wnt and β-catenin , and is applicable for research on osteoporosis and osteosarcoma [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 40391-99-9. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0012. | |
| RCGD423 | RCGD423 is a gp130 modulator that prevents the degradation of articular cartilage and promotes repair. Synonyms: N-(4-Bromophenyl)-4-Phenylthiazol-2-Amine; RCGD-423; RCGD 423. Grades: 98%. CAS No. 108237-91-8. Molecular formula: C15H11BrN2S. Mole weight: 331.2. | |
| Rheumatoid Factor, Control Serum, Human | Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology. Rheumatoid arthritis is a systemic disease characterized by chronic proliferation and inflammation of joint cartilage and supporting structures. RA is mainly defined by clinical criteria, in which systematic pathogenetic studies have been hampered by doubts about the presence of common pathogenetic mechanisms and the relative lack of unique laboratory findings. IgG rheumatoid factor has been reported to be present in sera of patients with rheumatoid arthritis both with and without IgM rheumatoid factor activity. Group: Biologicals. Grades: Serum. Pack Sizes: 2ml. US Biological Life Sciences. | Worldwide |
| Ro 32-3555 | Ro 32-3555 is a selective inhibitor of collagenases over the related human matrix metalloproteinases stromelysin 1, and gelatinases A and B (Ki values of 527, 154 and 59 nM, respectively). It inhibits both the cartilage and bone changes in this mouse model of OA, and thus shows great potential as a treatment of OA in humans. Synonyms: Ro-32-3555; Ro 32 3555; Ro323555; (αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide; Cipemastat; Ro32-3555; 190648-49-8; GFUITADOEPNRML-SJORKVTESA-N; UNII-02HQ4TYQ60; Trocade. Grades: ≥97% by HPLC. CAS No. 190648-49-8. Molecular formula: C22H36N4O5. Mole weight: 436.55. | |
| Semicarbazide hydrochloride | Semicarbazide hydrochloride is an orally active urea derivative. Semicarbazide hydrochloride binds to copper or iron in cells. Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase ( SSAO ). Semicarbazide hydrochloride damages cartilage, blood vessels, ovaries, testicles, and thyroid follicles [1] [2] [3] [4] [5] [6] [7] [8] [9]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Aminourea hydrochloride; Hydrazinecarboxamide hydrochloride. CAS No. 563-41-7. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-Y0470. | |
| sodium hyaluronate | The PhEur describes sodium hyaluronate as the sodium salt of hyaluronic acid, a glycosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units. Sodium hyaluronate occurs as white to off-white powder or granules. It is very hygroscopic. Synonyms: Hyaluronan; hyaluronate sodium; natrii hyaluronas; RITA HA C1-C. CAS No. 9067-32-7. Product ID: PE-0674. Molecular formula: (C14H20NO11Na)n. Mole weight: (401.3)n. Category: Humectant; lubricant; sustained-release agent. Product Keywords: Humectants Excipients; PE-0674; sodium hyaluronate; 9067-32-7; Hyaluronan; hyaluronate sodium; natrii hyaluronas; RITA HA C1-C. Chemical Name: Sodium hyaluronate. Grade: Pharmaceutical grade. Administration route: Topical gel. preparation. Dosage Form: Topical gel. preparation. Stability and Storage Conditions: Sodium hyaluronate should be stored in a cool, dry place in tightly sealed containers. The powder is stable for 3 years if stored in unopened containers. Source and Preparation: Sodium hyaluronate occurs naturally in vitreous humor, serum,chicken combs, shark skin, and whale cartilage; it is usually extracted and purified from chicken combs. It may also be manufactured by fermentation of selected Streptococcus zooepidemicus bacterial strains; sodium hyaluronate is removed from the fermentation medium by filtration and purified by ultrafiltration. It is then precipitated with an organic solvent and | |
| T-26c | T-26c is a selective matrix metalloproteinase-13 (MMP-13) inhibitor with IC50 value of 0.0069 nM. It inhibits IL-1β- and oncostatin M-induced collagen degradation in bovine nasal septum cartilage explants by 87.4% when used at a concentration of 0.1 μM. T-26c is used for the treatment of osteroarthritis and rhuematoid arthritis. Synonyms: 4-[[2-[(3-methoxyphenyl)methylcarbamoyl]-4-oxo-3H-thieno[2,3-d]pyrimidin-5-yl]methoxymethyl]benzoic acid. Grades: ≥98%. CAS No. 869296-13-9. Molecular formula: C24H21N3O6S. Mole weight: 479.5. | |
| T 26c disodium salt | T 26c disodium salt is a potent, selective and orally available MMP13 inhibitor (IC50 = 6.9 pM) with >2600-fold selectivity for MMP13 over related MMPs. T 26c inhibits degradation of bovine nasal septum cartilage explants in vitro. Synonyms: Disodium 4-[[[[2-[[[[3- (Methyloxy) phenyl]methyl]amino]carbonyl]-4-oxo-3, 4-dihydrothieno[2, 3-d]pyrimidin-5-yl]methyl]oxy]methyl]benzoate. Grades: ≥98% by HPLC. CAS No. 869298-22-6. Molecular formula: C24H19N3Na2O6S. Mole weight: 523.47. | |
| TMI 005 | TMI 005, also known as Apratastat, is a matrix metalloproteinase/tumour necrosis factor-α convertase (MMP/TACE) inhibitor for the treatment of rheumatoid arthritis. It inhibits secretion of soluble TNF-α and downregulates multiple MMPs, which is involved in cartilage destruction and bone erosions of RA. Uses: The treatment of rheumatoid arthritis. Synonyms: TMI-005; TMI005; TMI 005; XMT-1191; XMT 1191; XMT1191. Apratastat; (3S)-N-hydroxy-4-[4-(4-hydroxybut-2-ynoxy)phenyl]sulfonyl-2,2-dimethylthiomorpholine-3-carboxamide. Grades: 99%. CAS No. 287405-51-0. Molecular formula: C17H22N2O6S2. Mole weight: 414.5. | |
| Triamcinolone acetonide | Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 76-25-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0636. | |
| Xylosylated L-serine | Xylosylated L-serine is a molecule of high significance in the realm of examining and investigating the glycosylation pathways, cartilage degradation, and osteoarthritis. This biomolecule partakes in the creation of proteoglycans, the fundamental components of cartilage's extracellular matrix. Along with its pivotal role in cartilage formation, this molecule's potential therapeutic properties have also been studied, particularly in the context of inflammatory ailments. Synonyms: N-Fmoc-O-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-L-serine; Fmoc-L-Ser(β-Xyl(Ac3))-OH; L-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-; N-(9H-Fluorene-9-ylmethoxycarbonyl)-O-(2-O,3-O,4-O-triacetyl-beta-D-xylopyranosyl)-L-serine. Grades: ≥95%. CAS No. 105678-33-9. Molecular formula: C29H31NO12. Mole weight: 585.56. | |
| Chondroitin disaccharide di-triS tetrasodium salt | Chondroitin Disaccharide Di-TriS Tetrasodium Salt is a crucial biomolecular compound, serving as a foundational substrate for chondroitin sulfate. It exerts pronounced beneficial effects in studying symptoms associated with arthritis, endorsing the rejuvenation of cartilaginous structures and studying discomfort and inflammatory responses. Molecular formula: C14H17NNa4O20S3. Mole weight: 707.44. | |
| N-Acetyl-D-glucosamine | N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: N-Acetyl-2-amino-2-deoxy-D-glucose. CAS No. 7512-17-6. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-A0132. | |
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