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| Product | Description | |
|---|---|---|
| Cathepsin Inhibitor 1 | Cathepsin Inhibitor 1 is a pan-inhibitor of Cathepsin (L, L2, S, K, B). Uses: Designed for use in research and industrial production. Additional or Alternative Names: Cathepsin Inhibitor 1; Cathepsin-Inhibitor-1; CTS-IN-1; CTS IN 1. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 225120-65-0. Molecular formula: C20H24ClN5O2. Mole weight: 401.89. Purity: >98%. IUPACName: (S)-3-(tert-butyl)-N-(3-(3-chlorophenyl)-1-((cyanomethyl)amino)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide. Canonical SMILES: ClC1=CC=CC(C[C@@H](C(NCC#N)=O)NC(C2=CC(C(C)(C)C)=NN2C)=O)=C1. Product ID: ACM225120650. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Cathepsin Inhibitor 1 | Osteoarthritis is currently recognized as a chronic degenerative disease, which is caused by the loss of articular cartilage and damage to underlying bone, resulting in joint instability and pain. Cathepsin Inhibitor 1 is an inhibitor of Cathepsin. The IC50s for Cathepsin L, L2, S, K, B are 7.9, 6.7, 6.0, 5.5 and 5.2 nM, respectively. Synonyms: Cathepsin-Inhibitor-1; CTS-IN-1; CTS IN 1. Grades: ≥98%. CAS No. 225120-65-0. Molecular formula: C20H24ClN5O2. Mole weight: 401.89. |  |
| 1,1,2-Ethanetricarboxylic Acid 1,1,2-Triethyl Ester | 1,1,2-Ethanetricarboxylic Acid 1,1,2-Triethyl Ester is a useful synthetic intermediate. It can be used to prepare Isobutylsuccinic Acid (I780660) which was used to synthesize succinimide derivatives as inhibitors of human leukocyte elastase, cathepsin G and proteinase 3. Group: Biochemicals. Grades: Highly Purified. CAS No. 7459-46-3. Pack Sizes: 5g, 10g. Molecular Formula: C11H18O6. US Biological Life Sciences. |  Worldwide |
| 1- (2-Hydroxyphenyl) -4- (tert-butoxycarbonyl) piperazine | 1- (2-Hydroxyphenyl) -4- (tert-butoxycarbonyl) piperazine is an intermediate used to synthesize 2-(1-Piperazinyl)-benzenethiol which is used to used to prepare 3,5-dioxo-(2H,4H)-1,2,4-triazine as 5-HT1AR ligands. 1- (2-Hydroxyphenyl) -4- (tert-butoxycarbonyl) piperazine is also used to prepare nonpeptidic biaryl inhibitors of human cathepsin K in relation to treatment of osteoporosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 313657-51-1. Pack Sizes: 1g, 10g. Molecular Formula: C15H22N2O3, Molecular Weight: 278.35. US Biological Life Sciences. | Worldwide |
| 1, ?2-?Piperidinedicarboxyl ?ic Acid 1-?(Phenylmethyl) Ester | 1, ?2-?Piperidinedicarboxyl ?ic Acid 1-?(Phenylmethyl) Ester is used to prepare disubstituted azetidinones as selective inhibitors of cysteine protease cathepsin K. It is also used to synthesize 2-?[(R)?-?2-?methylpyrrolidin-?2-?yl]?-?1H-?benzimidazole-?4-?carboxamide (ABT-?888) as the Poly(ADP-?ribose) Polymerase (PARP) inhibitor for the treatment of cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 28697-07-6. Pack Sizes: 25g, 100g. Molecular Formula: C14H17NO4, Molecular Weight: 263.29. US Biological Life Sciences. | Worldwide |
| 1,3-Bis-(Z-Leu-Leu)-diaminoacetone | 1,3-Bis-(Z-Leu-Leu)-diaminoacetone, a cysteine protease inhibitor, can specifically and efficiently inhibit the processing of p-Prl signal peptide (IC50 ca. 50 nM) without affecting the activity of signal peptidase and lysosomal cathepsin, proteasome, and other proteases. Synonyms: (Z-LL)2 Ketone; Z-Leu-Leu-NH-CH2-CO-CH2-NH-Leu-Leu-Z; 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide; 1,3-di-(N-carboxybenzoyl-leucyl-leucyl)aminoacetone; Dibenzyl [(4S,7S,15S,18S)-7,15-diisobutyl-2,20-dimethyl-5,8,11,14,17-pentaoxo-6,9,13,16-tetraazahenicosane-4,18-diyl]biscarbamate. Grades: ≥95%. CAS No. 313664-40-3. Molecular formula: C43H64N6O9. Mole weight: 809.00. | |
| [1- (4-Bromophenyl) cyclopropyl]methanol | Used for preparation of amino acid derivatives as cathepsin cysteine protease inhibitors. Group: Biochemicals. Alternative Names: 1-(4-Bromophenyl)-1-cyclopropanemethanol; 1- (p-Bromophenyl) cyclopropanemethanol. Grades: Highly Purified. CAS No. 98480-31-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 1-Naphthalenylsulfonyl-Ile-Trp-aldehyde | 1-Naphthalenylsulfonyl-Ile-Trp-aldehyde is a potent, reversible, selective and cell-permeable cathepsin L inhibitor with an IC50 of 1.9 nM. It inhibits the release of bone Ca2+ and hydroxyproline in vitro and is useful in the treatment of osteoporosis. Synonyms: N-(1-Naphthalenylsulfonyl)-Ile-Trp-aldehyde; Pentanamide, N-[(1S)-1-formyl-2-(1H-indol-3-yl)ethyl]-3-methyl-2-[(1-naphthalenylsulfonyl)amino]-, (2S,3S)-; N-[(2S)-1-(1H-Indol-3-yl)-3-oxo-2-propanyl]-N2-(1-naphthylsulfonyl)-L-isoleucinamide; N-(1Naphthalenylsulfonyl)-IW-CHO; Cathepsin L Inhibitor IV. Grades: ≥95%. CAS No. 161709-56-4. Molecular formula: C27H29N3O4S. Mole weight: 491.61. | |
| 1-Pyrrolidinyl-3-pyridineacetic Acid | 1-Pyrrolidinyl-3-pyridineacetic Acid is a reagent that is used in the synthesis of phenylalanine cyanomethylamides as cathepsin B inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 933760-99-7. Pack Sizes: 10mg, 100mg. Molecular Formula: C12H15NO2, Molecular Weight: 205.25. US Biological Life Sciences. | Worldwide |
| 1-[ (tert-Butyloxycarbonyl) amino]propane-2, 3-diol | 1-[ (tert-Butyloxycarbonyl) amino]propane-2, 3-diol is a reagent used in the synthesis of analogs of Vestipitant, potent and orally NK1 antagonists. Also, it is the used in the synthesis of N-Boc-2-aminoacetaldehyde (B600600), which is used in the synthesis of carbohydrates as well as studies relating to inhibitors of cathepsin K. Group: Biochemicals. Grades: Highly Purified. CAS No. 137618-48-5. Pack Sizes: 250mg, 1g. Molecular Formula: C8H17NO4, Molecular Weight: 191.22. US Biological Life Sciences. | Worldwide |
| 2-(1-Piperazinyl)-phenol Dihydrochloride | 2-(1-Piperazinyl)-phenol Dihydrochloride, is used to prepare nonpeptidic biaryl inhibitors of human cathepsin K in relation to treatment of osteoporosis. It is also used to synthesize serotonin transporters/histamine H3 receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 667864-86-0. Pack Sizes: 1g, 10g. Molecular Formula: C10H14N2O 2HCl. US Biological Life Sciences. | Worldwide |
| 2,3,4-Trimethyl-3-pentanol | 2,3,4-Trimethyl-3-pentanol is used to prepare cathepsin K inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 3054-92-0. Pack Sizes: 1g, 5g. Molecular Formula: C8H18O, Molecular Weight: 130.229999999999. US Biological Life Sciences. | Worldwide |
| 2,5-Difluorobenzoic acid | 2,5-Difluorobenzoic Acid acts as a reagent in the synthesis of rutaecarpine and analogs used for the removal of caffeine from the body. Prepparation of quinolone carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase (Erratum). Preparation, molecular docking, and bioactivity of α-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis. Also used as new passive water tracers for oil field applications. Synonyms: NSC 190310; 5-Difluorobenzoic acid; 2,5-difluorobenzoate. Grades: ≥95%. CAS No. 2991-28-8. Molecular formula: C7H4F2O2. Mole weight: 158.10. | |
| 2-Amino-2-oxo-acetic Acid Ethyl Ester | 2-Amino-2-oxo-acetic Acid Ethyl Ester is a reagent used to prepare methanotetra hydroiso quinolinecarboxyl ic acid. It can also be used in preparation of 1,2,4-Thiadiazole, a Cathepsin B inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 617-36-7. Pack Sizes: 5g, 10g. Molecular Formula: C4H7NO3, Molecular Weight: 117.1. US Biological Life Sciences. | Worldwide |
| 2-Chloro-3- (trifluoromethyl) benzoic Acid | 2-Chloro-3- (trifluoromethyl) benzoic Acid is a reactant in the preparation of trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 39226-97-6. Pack Sizes: 1g, 10g. Molecular Formula: C8H4ClF3O2, Molecular Weight: 224.56. US Biological Life Sciences. | Worldwide |
| 2-Chloro-N-methoxy-N-methylbenzamide | 2-Chloro-N-methoxy-N-methylbenzamide was used as a reagent in the synthesis of functionalized β-oxonitriles. Also used in the synthesis of potent thiosemicarbazone based cathepsin L inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 289686-74-4. Pack Sizes: 500mg, 1g. Molecular Formula: C9H10ClNO2, Molecular Weight: 199.63. US Biological Life Sciences. | Worldwide |
| 2-Pyrimidinecarbonitrile | Cathepsin K is a lysosomal cysteine protease found in osteoclasts whose elevated activity has been linked to the formation of osteoporosis and arthritis. 2-cyano-Pyrimidine is a cathepsin K inhibitor. Synonyms: pyrimidine-2-carbonitrile. Grades: 95+%. CAS No. 14080-23-0. Molecular formula: C5H3N3. Mole weight: 105.10. | |
| (2R,?3R)?-2-Bromo-3-hydroxybutanedioic Acid 1,4-Diethyl Ester | (2R,?3R)?-2-Bromo-3-hydroxybutanedioic Acid 1,4-Diethyl Ester is an intermediate in the synthesis of derivative of E-64 an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. Group: Biochemicals. Grades: Highly Purified. CAS No. 80640-15-9. Pack Sizes: 1g, 5g. Molecular Formula: C8H13BrO5. US Biological Life Sciences. | Worldwide |
| (2R)-4-Phenylbutan-2-amine-d3 | (2R)-4-Phenylbutan-2-amine is an isotope labelled intermediate in the synthesis of potent Cathepsin S inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C10H12D3N. US Biological Life Sciences. | Worldwide |
| (2R)-4-Phenylbutan-2-amine p-Toluenesulfonic Acid | (2R)-4-Phenylbutan-2-amine p-Toluenesulfonic Acid is an intermediate in the synthesis of potent Cathepsin S inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C17H23NO3S. US Biological Life Sciences. | Worldwide |
| (2S, 3S) -3- [ [ [ (1S) -1- [ [ (4-Azidobutyl) amino] carbonyl] -3-methylbutyl] amino] carbonyl] -2-oxiranecarboxylic Acid Ethyl Ester | N3Le is a derivative of E-64 an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1174021-95-4. Pack Sizes: 1mg, 10mg. Molecular Formula: C16H27N5O5. US Biological Life Sciences. | Worldwide |
| 3-Cyano-1,2,4-triazole | A cyano substituted triazole with inhibitory effects on cathepsin K used in a study of the electrophilicity and reactivity of diverse nitrile-containing compounds and its correlation to the mechanism-of-action. Group: Biochemicals. Alternative Names: 1H-1,2,4-Triazole-3-carbonitrile; s-Triazole-3-carbonitrile. Grades: Highly Purified. CAS No. 3641-10-9. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 3-epi-Ursolic Acid | 3-epi-Ursolic Acid is a potent inhibitor against glycogen phosphorylase which makes it a potential rug for treatment of type-2 diabetes and other diseases associated with glycogen metabolism. It is also a part of the group of triterpenoids that act as novel inhibitors of Human Cathepsin L. Group: Biochemicals. Grades: Highly Purified. CAS No. 989-30-0. Pack Sizes: 5mg, 10mg. Molecular Formula: C30H48O3, Molecular Weight: 456.7. US Biological Life Sciences. | Worldwide |
| 3-Methyl-D-phenylalanine | 3-Methyl-D-phenylalanine is a derivative of D-Phenylalanine and is used as a reagent in the synthesis of aminophenylpropanyl phosphate derivatives which can exhibit pin1 inhibitory activity. 3-Methyl-D-phenylalanine is also used in the preparation of N-arylaminonitriles which are useful as bioavailable peptidomimetic inhibitors of cathepsin B. Synonyms: D-Phe(3-Me)-OH; m-Methyl-D-phenylalanine; (R)-2-Amino-3-(3-methylphenyl)propanoic acid; (R)-2-Amino-3-(m-tolyl)propanoic acid; D-3-Methylphenylalanine; D-PHENYLALANINE, 3-METHYL-; 3-Methy-D-Phenylalanine; H-D-PHE(3-ME)-OH; (2R)-2-amino-3-(3-methylphenyl)propanoic acid; (R)-2-amino-3-m-tolylpropanoic acid. Grades: ≥ 99% (HPLC). CAS No. 114926-39-5. Molecular formula: C10H13NO2. Mole weight: 179.22. | |
| 5-Nitro-8-hydroxyquinoline | 5-Nitro-8-hydroxyquinoline is an antimicrobial agent used for the treatment of urinary tract infection. 5-Nitro-8-hydroxyquinoline is also a potent and reversible inhibitor of cathepsin B. 5-Nitro-8-hydroxyquinoline has been shown to have anti-cancer activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 4008-48-4. Pack Sizes: 10g, 25g, 100g, 250g. Molecular Formula: C?H?N?O?, Melting Point: >179ºC (dec.). US Biological Life Sciences. | Worldwide |
| Acetyl-Calpastatin(184-210)(human) | Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with K i values of 0.2 nM and 6 μM for μ-calpain and cathepsin L, respectively [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 123714-50-1. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P1081. |  |
| ALLM | ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Calpain inhibitor II. CAS No. 110115-07-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-118355. | |
| ALLM - CAS 110115-07-6 | Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). Group: Fluorescence/luminescence spectroscopy. |  |
| ALLN - CAS 110044-82-1 | Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Group: Fluorescence/luminescence spectroscopy. | |
| Aloxistatin | Aloxistatin is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain, which predicted to function against SARS-CoV-2 infection. Synonyms: L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide; L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester; (2S, 3S) -3-[[[ (1S) -3-Methyl-1-[[ (3-methylbutyl) amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic Acid Ethyl Ester; E 64c ethyl ester; E 64d; EP 453; EST; Loxistatin; NSC 694281; (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester. Grades: 98%. CAS No. 88321-09-9. Molecular formula: C17H30N2O5. Mole weight: 342.43. | |
| Aminopeptidase N Inhibitor | Membrane alanyl aminopeptidase is also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N), which is an enzyme that in humans is encoded by the ANPEP gene. Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Synonyms: AP-N Inhibitor. Grades: ≥95%. CAS No. 596108-59-7. Molecular formula: C17H10N2O8. Mole weight: 370.27. | |
| Aurantiamide acetate | Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Asperglaucide. CAS No. 56121-42-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2905. | |
| AZD3839 free base | AZD3839 free base is a potent and selective orally active, brain-permeable BACE1 inhibitor ( K i=26 nM). AZD3839 free base shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. AZD3839 free base exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 free base can be used for the research of Alzheimer's disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1227163-84-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-13438. | |
| Balicatib | The cathepsin K inhibitor AAE-581 (balicatib) as the most advanced of them passed Phase II clinical trials in 2005. Eighty adult female Macaca fascicularis underwent bilateral ovariectomies and were dosed twice daily by oral gavage with balicatib at 0, 3, 10, and 50 mg/kg for 18 months (groups O, L, M, H, respectively). Approximately 1 month after treatment initiation, the 50 mg/kg dose was decreased to 30 mg/kg. Twenty animals underwent sham-ovariectomies (group S). Bone mass was measured at 3-6 month intervals. At 18 months, vertebra and femur were collected for histomorphometry. Synonyms: AAE581; AAE-581; AAE 581. Grades: 0.98. CAS No. 354813-19-7. Molecular formula: C23H33N5O2. Mole weight: 411.54. | |
| β-Cyclopentyl-L-alanine | β-Cyclopentyl-L-alanine is used as a reagent in the synthesis of functionalized N-arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Synonyms: β-Cyclopentyl-L-Ala-OH; (S)-2-Amino-3-cyclopentylpropanoic acid; 3-Cyclopentane-L-alanine; L-3-Cyclopentylalanine; H-Cpa-OH; (2S)-2-amino-3-cyclopentylpropanoic acid; 3-cyclopentylalanine; H-Ala(cPen)-OH; (S)-alfa-Amino-cyclopentanepropanoic acid; beta-cyclopentyl-l-alanine; beta-Cyclopentyl-L-Ala-OH; H Cpa OH. Grades: ≥ 99.5%. CAS No. 99295-82-6. Molecular formula: C8H15NO2. Mole weight: 157.09. | |
| Boc-Gly-Merrifield Resin | Boc-Gly-Merrifield Resin (CAS# 89711-08-0) is used in the synthesis of carbohydrates as well as studies relating to inhibitors of cathepsin K. Synonyms: tert-Butyl N-(2-oxoethyl)carbamate; tert-butyl 2-oxoethylcarbamate; tert-butyl (2-oxoethyl)carbamate; N-Boc-2-aminoacetaldehyde. Grades: 95 %. CAS No. 89711-08-0. Molecular formula: C7H13NO3. Mole weight: 159.18. | |
| CA 074 | CA 074 is a potent and selective inhibitor of cathepsin B (Ki = 2-5 nM). It reduces bone metastasis in a 4T1.2 breast cancer model. Uses: Cysteine proteinase inhibitors. Synonyms: CA-074; CA074; CA 074; N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline. Grades: ≥98% by HPLC. CAS No. 134448-10-5. Molecular formula: C18H29N3O6. Mole weight: 383.44. | |
| CA-074 | CA-074 is a potent inhibitor of cathepsin B with a K i of 2 to 5 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 134448-10-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-103350. | |
| CA-074 methyl ester | CA-074 Me is a membrane-permeable inhibitor of irreversible cathepsin B derived from CA-074. CA-074 Me would be hydrolyzed by intracellular esterases to CA-074, the active compound. Synonyms: Ca-074Me; Ca 074Me; Ca074Me; Cathepsin B Inhibitor IV; MFCD03452890; (S)-methyl 1-((2S,3S)-3-methyl-2-((2S,3S)-3-(propylcarbamoyl)oxirane-2-carboxamido)pentanoyl)pyrrolidine-2-carboxylate; CA-074 Me. Grades: 99.04 %. CAS No. 147859-80-1. Molecular formula: C19H31N3O6. Mole weight: 397.47. | |
| CA-074 methyl ester | CA-074 methyl ester is a specific inhibitor of Cathepsin B , which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CA-074Me. CAS No. 147859-80-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-100350. | |
| CA 074 (N-[[(2S,3S)-3-[(Propylamino)carbony l]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline) | Inhibitor of cathepsin B (Ki = 2-5nm). Displays selectivity over cathepsins H and L (Ki = 40-200um). Shown to reduce bone metastasis in a 4T1.2 breast cancer model. Group: Biochemicals. Grades: Highly Purified. CAS No. 134448-10-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Calpain Inhibitor II | Calpain inhibitor II is a cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). It inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Calpain inhibitor II can block nitric oxide production by interfering with transcription of the inducible nitric oxide synthase gene, which is a weak inhibitor of proteasome. It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems. Uses: Cysteine proteinase inhibitors. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-; L-Leucinamide, N-acetyl-L-leucyl-N-[1-formyl-3-(methylthio)propyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide; ALLM; Calp II; CI 2; SUAM 312; N-acetylleucyl-leucyl-methioninal; Ac-Leu-Leu-Met-al; N-acetyl-L-leucyl-L-leucyl-L-methioninal. Grades: ≥98%. CAS No. 110115-07-6. Molecular formula: C19H35N3O4S. Mole weight: 401.57. | |
| Calpain Inhibitor XII | Calpain Inhibitor XII is a cell-permeable, potent, selective, reversible, and active-site-directed inhibitor of calpain-1 with Ki of 19 nM. It has been shown to inhibit calpain-2 with Ki of 120 nM and human cathepsin B with Ki of 750 nM. Calpain inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury. Synonyms: Z-L-Nva-CONH-CH2-2-Py. Grades: ≥90%. CAS No. 181769-57-3. Molecular formula: C26H34N4O5. Mole weight: 482.6. | |
| Calpeptin | Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID 50 of 40 nM for Calpain I in human platelets [1]. Calpeptin is also an inhibitor of cathepsin K [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 117591-20-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100223. | |
| Cathepsin G Inhibitor I | Cathepsin G inhibitor I is a potent and selective inhibitor of cathepsin G with IC50 of 53 nM. It weakly inhibits chymotrypsin and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase. Synonyms: Cathepsin G Inhibitor I; 429676-93-7; Cathepsin G Inhibitor; CHEMBL164694; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid; SCHEMBL1613660; DTXSID80431393; BDBM50139754; HY-103351; CS-0027703; A918760; (2-{3-[(1-Benzoyl-piperidin-4-yl)-methyl-carbamoyl]-naphthalen-2-yl}-1-naphthalen-1-yl-2-oxo-ethyl)-phosphonic acid; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2 oxoethyl]phosphonic acid. Grades: ≥95%. CAS No. 429676-93-7. Molecular formula: C36H33N2O6P. Mole weight: 620.6. | |
| Cathepsin L Inhibitor | Cathepsin L inhibitor is a potent inhibitor of cathepsin L with IC50 of 0.85 nM. It is trypanocidal with an ED50 value of 45 nM against T. brucei that is well below the ED50 value of 21,500 nM for human HL-60 cells. In vivo, cathepsin L inhibitor (2.5-10 mg/kg) inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner. Cathepsin L inhibitor can also completely suppress osteoclastic pit formation on femur slices isolated from bovine cortical bone. Synonyms: Z-FY-CHO; Z-Phe-Tyr-aldehyde; SB 412515; N-(benzyloxycarbonyl)-phenylalanyl-l-tyrosinal. Grades: ≥95%. CAS No. 167498-29-5. Molecular formula: C26H26N2O5. Mole weight: 446.49. | |
| Cathepsin S inhibitor | Cathepsin S is expressed in antigen-presenting cells and plays a role in invariant chain processing and major histocompatibility complex class II (MHCII) antigen presentation leading to CD4+ T-cell activation. An oral Cathepsin S inhibitor that blocks MHCII antigen presentation could result in a T-cell-selective immunosuppressant agent with improved safety over the current standard of care for the treatment of rheumatoid arthritis, psoriasis, multiple sclerosis and other autoimmune-based inflammatory diseases. Synonyms: LY3000328; LY-3000328; LY 3000328. Cathepsin S inhibitor. Grades: >98%. CAS No. 1373215-15-6. Molecular formula: C25H29FN4O5. Mole weight: 484.52. | |
| Clasto-Lactacystin beta-lactone (Omuralide) | In vitro lactacystin does not react with the proteasome. It rather undergoes a spontaneous conversion (lactonization) to the active metabolite clasto-lactacystin beta-lactone. Potent and selective irreversible and cell permeable proteasome inhibitor. Inhibits the chymotrypsin-like, trypsin-like and caspase-like peptidase activity of the proteasome. The active metabolite of lactacystin with higher potency since it does not require hydrolysis in order to become cell permeable. Calpain and cathepsin inhibitor. Apoptosis inducer. Anticancer compound. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Induces neuritogenesis. Autophagy inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 154226-60-5. Pack Sizes: 100ug. Molecular Formula: C10H15NO4, Molecular Weight: 213.2. US Biological Life Sciences. | Worldwide |
| Dihydroeponemycin | Dihydroeponemycin is a natural, irreversible inhibitor of proteasomal degradation of proteins that acts by binding the IFN-γ-inducible proteins LMP2 and LMP7, as well as the constitutive proteasome subunit X. It does not inhibit calpain or trypsin and has minor effects on cathepsin B and chymotrypsin at higher concentrations. It is cell-permeable and induces apoptosis in bovine aortic endothelial cells. Grades: ≥98%. CAS No. 126463-64-7. Molecular formula: C20H36N2O6. Mole weight: 400.5. | |
| E-64d | E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to interfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats. Group: Biochemicals. Alternative Names: (2S, 3S) -3- [ [ [ (1S) -3-Methyl-1- [ [ (3-methylbutyl) amino] carbonyl] butyl] amino] carbonyl] -2-oxiranecarboxylic Acid Ethyl Ester; Aloxistatin; E 64c ethyl ester; E 64d; EP 453; EST; EST (pharmaceutical); Loxistatin; NSC 694281. Grades: Highly Purified. CAS No. 88321-09-9. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| FICT-FF-FMK | FICT-FF-FMK is a fluorescein isothiocyanate (FITC)-conjugated inhibitor of cathepsin B and cathepsin L, which can be used for detecting cathepsin B and cathepsin L in live cells. Synonyms: FICT-Phe-Phe-FMK; FICT-Phe-Phe-Fluoromethylketone. Grades: >95%. Molecular formula: C41H34FN3O6S. Mole weight: 715.80. | |
| Gallinamide A TFA | Gallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L ( CatL ) (IC 50 : 17.6 pM). Gallinamide A TFA inhibits SARS-CoV-2 infection by inhibiting CatL (EC 50 : 28 nM). Gallinamide A TFA also inhibits Plasmodium falciparum (IC 50 : 50 nM) [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 1352920-57-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N10109A. | |
| GW311616 | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616; GW 311616. Grades: >98%. CAS No. 198062-54-3. Molecular formula: C19H31N3O4S. Mole weight: 397.53. | |
| GW311616 hydrochloride | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616 hydrochloride; GW 311616 hydrochloride; GW311616A. Grades: >98%. CAS No. 197890-44-1. Molecular formula: C19H32ClN3O4S. Mole weight: 433.99. | |
| JNJ10311795 | JNJ10311795 is a dual inhibitor of Chymase and leukocyte Proteases Cathepsin G. It has inflammation therapeutic efficacy in animals models. Uses: Jnj10311795 has inflammation therapeutic efficacy. Synonyms: JNJ-10311795; JNJ 10311795; JNJ10311795. [2-[3-[Methyl-[1-(naphthalene-2-carbonyl)piperidin-4-yl]carbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid;Phosphonic acid, (2-(3-((methyl(1-(2-naphthalenylcarbonyl)-4-piperidinyl)amino)carbonyl)-2-naphthalenyl)-1-(1-naph. Grades: 98%. CAS No. 518062-14-1. Molecular formula: C40H35N2O6P. Mole weight: 670.70. | |
| K777 | K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC 50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi , and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC 50 values of 0.68 nM and 0.87 nM, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 233277-99-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119293. | |
| L006235 | Potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence. Synonyms: L-006235; L 006235; Benzamide, N-[1-[[ (cyanomethyl) amino]carbonyl]cyclohexyl]-4-[2- (4-methyl-1-piperazinyl) -4-thiazolyl]-. Grades: 98%. CAS No. 294623-49-7. Molecular formula: C24H30N6O2S. Mole weight: 466.60. | |
| MDL 28170 | MDL 28170 is a calpain and cathepsin B inhibitor with Ki values of 10 and 25 nM respectively. It shows neuroprotective effects in vivo. MDL 28170 can attenuate depression in myocardial contractile performance which occurs during reperfusion following cardiac ischemia. Synonyms: benzyl N-[(2S)-3-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]butan-2-yl]carbamate. Grades: ≥ 95 % by HPLC. CAS No. 88191-84-8. Molecular formula: C22H26N2O4. Mole weight: 382.45. | |
| MDL 28170, Z-Val-Phe-CHO, (Carbobenzoxy-valinyl-phenylalaninal, Calpain Inhibitor III) | A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25nm respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Modulates the formation of Ab formation by inhibiting the formation of intermediate Ab46 and protecting Ab from degradation. Group: Biochemicals. Grades: Highly Purified. CAS No. 88191-84-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MG-101 | MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with K i s of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Calpain inhibitor I; Ac-LLnL-CHO; ALLN. CAS No. 110044-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18964. | |
| MG-132 (Z-Leu-Leu-Leu-CHO) | Potent, cell permeable and selective, reversible proteasome inhibitor. Blocks degradation of short-lived proteins and induces a heat shock response. NF-kB activation inhibitor through IκB degradation. Cell permeable, reversible peptide aldehyde inhibitor. Calpain and cathepsin inhibitor. Has anticancer properties by inducing cell cycle arrest and activating apoptosis in various cancer cell lines. Has adjuvant / chemosensitizer potential. Neurite outgrowth stimulator in PC12 cells. Prevents beta-secretase cleavage. Autophagy activator. Group: Biochemicals. Alternative Names: Z-Leu-Leu-Leu-al; Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal; Proteasome Inhibitor XI). Grades: Highly Purified. CAS No. 133407-82-6. Pack Sizes: 5mg, 10mg. Molecular Formula: C26H41N3O5, Sequence: Z-Leu-Leu-Leu-aldeyhde. US Biological Life Sciences. | Worldwide |
| MK-0822 | MK-0822 is a newly developed bone-targeting dual action pro-drug for osteoporosis and bone metastasis. It is also an inhibitor of cathepsin K, an enzyme involved in bone resorption. Group: Biochemicals. Alternative Names: N- (1-cyanocyclopropyl) -4-fluoro-N2-{ (1S) -2, 2, 2-trifluoro-1-[4'- (methylsulfonyl) biphenyl-4-yl]ethyl}-L-leucinamide, Odanacatib. Grades: Highly Purified. CAS No. 603139-19-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Nα-Benzoyl-L-arginine amide hydrochloride | A substrate for cathepsin and competitive inhibitor of human urokinase. Synonyms: Bz-L-Arg-NH2 HCl; (S)-N-(1-Amino-5-guanidino-1-oxopentan-2-yl)benzamide hydrochloride; N-ALPHA-BENZOYL-L-ARGININAMIDE HYDROCHLORIDE; N-α-BENZOYL-L-ARGININAMIDE HYDROCHLORIDE; Nα-Benzoyl-L-argininamide Hydrochloride Monohydrate. Grades: ≥ 99% (TLC). CAS No. 4299-03-0. Molecular formula: C13H19N5O2·HCl. Mole weight: 313.80. | |
| N-Boc-phenylalaninal | An amino aldehyde. A potent human cathepsin K inhibitor. Group: Biochemicals. Alternative Names: N-[(1S)-1-Formyl-2-phenylethyl]carbamic Acid 1,1-Dimethylethyl Ester; (S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanal; Boc-L-phenylalaninal; Boc-phenylalaninal; N- (tert-Butoxycarbonyl) phenylalaninal. Grades: Highly Purified. CAS No. 72155-45-4. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| N-Boc-phenyl-d5-alaninal | An isotope Labeled amino aldehyde. A potent human cathepsin K inhibitor. Group: Biochemicals. Alternative Names: N-[(1S)-1-Formyl-2-(phenyl-d5)-ethyl]carbamic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 1217724-86-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Odanacatib | Odanacatib (MK-0822) is a potent and selective inhibitor of cathepsin K , with an IC 50 of 0.2 nM for human cathepsin K. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-0822. CAS No. 603139-19-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10042. | |
| Olgotrelvir sodium | Olgotrelvir sodium is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin ( Cathepsin L ). Olgotrelvir sodium can effectively inhibit both SARS-CoV-2 replication and entry into host cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: STI-1558 sodium. CAS No. 2763596-72-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-156655A. | |
| ONO-5334 | NO-5334 is cathepsin K inhibitor Ki values of 0.1 nM for human. It can improve bone strength by preferentially increasing cortical bone mass in ovariectomized rats. ONO-5334 can also inhibit N-terminal and C-terminal collagen crosslinks in serum and urine in postmenopausal women. In Feb 2012, Phase-II for Osteoporosis in European Union was discontinued. Uses: Osteoporosis. Synonyms: ONO-5334; ONO 5334; ONO5334. N-((S)-3-(2-((R,Z)-3,4-dimethylthiazolidin-2-ylidene)hydrazinyl)-2,3-dioxo-1-(tetrahydro-2H-pyran-4-yl)propyl)cycloheptanecarboxamide. Grades: 98%. CAS No. 868273-90-9. Molecular formula: C21H34N4O4S. Mole weight: 438.59. | |
| P005091 (USP7 Inhibitor, 1-[5-[(2,3-Dichlorophenyl)thio]-4-n itro-2-thienyl]ethanone) | Selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2um). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 882257-11-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PAβN dihydrochloride | PAβN dihydrochloride is an efflux pump inhibitor and a substrate for dipeptidyl aminopeptidase I (cathepsin C). Synonyms: H-Phe-Arg-βNA.2HCl; Phe-Arg β-naphthylamide dihydrochloride. Grades: ≥ 99% (TLC). CAS No. 100929-99-5. Molecular formula: C25H32Cl2N6O2. Mole weight: 519.47. | |
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