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| Product | Description | |
|---|---|---|
| 2-[ (2-Aminoethyl) amino]-4-[[3- (trifluoromethyl) phenyl]amino]-5-pyrimidinecarboxamide Hydrochloride | 2-[ (2-Aminoethyl) amino]-4-[[3- (trifluoromethyl) phenyl]amino]-5-pyrimidinecarboxamide Hydrochloride was identified via a small molecule screening assay. In addition, this compound inhibits tyrosine kinase and may be a useful reagent to investigate cellular signalling pathways. Group: Biochemicals. Grades: Highly Purified. CAS No. 227449-73-2. Pack Sizes: 500ug, 1mg. Molecular Formula: C14H17Cl2F3N6O, Molecular Weight: 413.23. US Biological Life Sciences. |  Worldwide |
| 3-((4-Fluorophenethyl)amino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione | 3-((4-Fluorophenethyl)amino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione acts as an enhancer of Wnt signalling, involved in cell proliferation or differentiation, via inhibition of glycogen synthase kinase 3 beta (GSK-3 β). Group: Biochemicals. Grades: Highly Purified. CAS No. 1129669-05-1. Pack Sizes: 10mg, 50 mg. Molecular Formula: C22H20FN3O2, Molecular Weight: 377.41. US Biological Life Sciences. | Worldwide |
| 6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one | KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. It blocks Akt signalling through the PI3K pathway, and inhibits cell proliferation while inducing apoptosis of thyroid cancer cells. Synonyms: 6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one. Grades: ≥95%. CAS No. 1374996-60-7. Molecular formula: C20H8N12O2. Mole weight: 448.4. |  |
| 8-[(6-Amino)hexyl]-amino-GTP - ATTO-Rho6G | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-Rho6G, a fluorescent dye with immense potential in biomedical research, offers a remarkable avenue for scientists to visualize GTP-binding proteins in live cells. Its affinity for GTP and ability to probe cell signalling pathways associated with GTP, make it an essential tool in drug discovery efforts aimed at combating diseases like cancer and Alzheimer's. Get your hands on this cutting-edge dye today and discover the realm of possibilities it holds! Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO Rho6G, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C47H63N10O17P3 (free acid). Mole weight: 1132.36 (free acid). | |
| A66 | Inhibition of p110α alone by A66 treatment is sufficient to block insulin signalling to Akt/PKB in certain cell lines that harbor H1047R mutations in PIK3CA and have high levels of p110α and class-Ia PI3K activity. Synonyms: A66; A-66; A 66. Grades: >98%. CAS No. 1166227-08-2. Molecular formula: C17H23N5O2S2. Mole weight: 393.53. | |
| acyl-homoserine-lactone acylase | Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes. Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria. This quorum-quenching enzyme removes the fatty-acid side chain from the homoserine l...ion, as found in N-(3-oxododecanoyl)-L-homoserine lactone, do not affect this activity. Group: Enzymes. Synonyms: acyl-homoserine lactone acylase; AHL-acylase; AiiD; N-acyl-homoserine lactone acylase; PA2385 protein; quorum-quenching AHL acylase; quorum-quenching enzyme; QuiP. Enzyme Commission Number: EC 3.5.1.97. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4489; acyl-homoserine-lactone acylase; EC 3.5.1.97; acyl-homoserine lactone acylase; AHL-acylase; AiiD; N-acyl-homoserine lactone acylase; PA2385 protein; quorum-quenching AHL acylase; quorum-quenching enzyme; QuiP. Cat No: EXWM-4489. |  |
| acyl-homoserine-lactone synthase | Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes. N-(3-Oxohexanoyl)-[acyl-carrier protein] and hexanoyl-[acyl-carrier protein] are the best substrates. The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier protein] rather than from fatty-acid degradation through acyl-CoA. S-Adenosyl-L-methionine cannot be rep...No. 176023-66-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2126; acyl-homoserine-lactone synthase; EC 2.3.1.184; 176023-66-8; acyl-homoserine lactone synthase; acyl homoserine lactone synthase; acyl-homoserinelactone synthase; acylhomoserine lactone synthase; AHL synthase; AHS; AHSL synthase; AhyI; AinS; AinS protein; autoinducer synthase; autoinducer synthesis protein rhlI; EsaI; ExpISCC1; ExpISCC3065; LasI; LasR; LuxI; LuxI protein; LuxM; N-acyl homoserine lactone synthase; RhlI; YspI acyl-[acyl carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadeno | |
| alpha-Bisabolol | alpha-Bisabolol, an orally active sesquiterpene alcohol, induces cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol exerts a protective action against Cisplatin (HY-17394)-induced nephrotoxicity by mitigating inflammation and oxidative stress through the inhibition of NFκB activation. alpha-Bisabolol exhibits anti-inflammatory, analgesic, antibiotic and anticancer activities [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 515-69-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-121222. |  |
| Amarogentin | Amarogentin exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways and displays immunomodulatory effects in human mast cells and keratinocytes. It inhibits the growth of SNU-16 human gastric cancer cells (IC50 = 12.4 μM) and increases apoptosis when used at a concentration of 50 μM. Amarogentin dose-dependently reduces tumor growth in a SNU-16 nude mouse xenograft model. Amarogentin may offer therapeutic potential for preventing or treating thromboembolic disorders, it prevents platelet activation through the inhibition of PLC γ2-PKC cascade and MAPK pathway. Synonyms: Amarogentin; 21018-84-8; 5L82GT5I0W; [(2S,3R,4S,5S,6R)-2-[[(3S,4R,4aS)-4-ethenyl-8-oxo-4,4a,5,6-tetrahydro-3H-pyrano[3,4-c]pyran-3-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl] 2,4-dihydroxy-6-(3-hydroxyphenyl)benzoate; sweroside-2'-(3'',5'',3'''-trihydroxydiphenyl)-2''-carboxylic acid ester; (4aR)-5t-ethenyl-6c-[O(2)-(3,5,3'-trihydroxybiphenyl-2-ylcarbonyl)-beta-D-glucopyranosyloxy]-4,4ar,5,6-tetrahydro-3H-pyrano[3,4-c]pyran-1-one; (4aS,5R,6S)-5-ethenyl-1-oxo-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-6-yl- 2-O-[(3,3',5-trihydroxybiphenyl-2-yl)carbonyl]-beta-D-glucopyranoside. Grades: ≥98%. CAS No. 21018-84-8. Molecular formula: C29H30O13. Mole weight: 586.54. | |
| Amarogentin | Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis , arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 21018-84-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2447. | |
| Anisomycin (Flagecidin, Antibiotic SA 3097C1, Antibiotic PA 106, Anhydroscopin A, NSC) | Anisomycin is a phenyl methyl enepyrrolidine first isolated from Streptomyces griseolus in 1954 as an antiprotozoan with antifungal activity. Anisomycin acts as an inhibitor of protein synthesis by binding to the 60S ribosomal subunit. Interestingly, anisomycin has found use for the induction of amnesia in animal models. More recently, anisomycin has been demonstrated to induce apoptosis, to be a selective signalling agonist, to activate mitogen-activated protein (MAP) kinases and to be immunomodulatory via its action on T cells. Group: Biochemicals. Alternative Names: ((2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate. Grades: Highly Purified. CAS No. 22862-76-6. Pack Sizes: 25mg, 100mg, 250mg. US Biological Life Sciences. | Worldwide |
| Atiprimod | atiprimod is orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis. Synonyms: azaspirane; SKF 106615; SKF106615; SKF-106615; SK&F 106615; SK&F-106615. CAS No. 123018-47-3. Molecular formula: C22H44N2. Mole weight: 336.60. | |
| C188-9 | C188-9 is a STAT3 inhibitor. HDM-induced airway inflammation, remodeling, and Th2/Th17-type cell accumulation involve STAT3 activation that can be prevented by C188-9 treatment. STAT3 inhibition with C188-9 resulted in attenuated skin fibrosis, myofibroblast accumulation, pro-fibrotic gene expression and collagen deposition in both mouse models of skin fibrosis. C188-9 decreased in vitro dermal fibroblast production of fibrotic genes induced by IL-6 trans-signalling and TGF-&beta. Finally, TGF-β induced phosphotyrosylation of STAT3 in a SMAD3-dependent manner. Group: Inhibitors. Alternative Names: C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084. CAS No. 432001-19-9. Molecular formula: C27H21NO5S. Mole weight: 471.52. Appearance: Pinky beige solid powder. Purity: >98%. IUPACName: N-(1',2-dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide. Canonical SMILES: O=S (C1=CC=C (OC)C=C1) (NC2=C3C=CC=CC3=C (O)C (C4=C5C=CC=CC5=CC=C4O)=C2)=O. Catalog: ACM432001199. |  |
| Calmodulin (58-70) | Calmodulin (58-70) is a fragment of Calmodulin, a calcium-binding protein found in the cytoplasm of all eukaryotic cells. It interacts with many other proteins in the cell, and acts as a regulator or an effector molecule in a wide variety of cellular functions. These functions include things as diverse as regulation of the cell cycle, intracellular signalling, fertilization, and muscle contraction. | |
| caspase-10 | Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62). Like caspase-8, caspase-10 contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation. The enzyme has many overlapping substrates in common with caspase-8, such as RIP (the cleavage of which impairs NF-κB survival signalling and starts the cell-death process) and PAK2 (associated with some of the morphological features of apoptosis, such as cell rounding and apoptotic body formation). Bid, a Bcl2 protein, can be cleaved by caspase-3 (EC 3.4.22.56), caspase-8 and caspase-10 at Lys-Gln-Thr-Asp? ...u-Thr-Asp? to yield a p13 fragment that is not N-myristoylated. Belongs in peptidase family C14. Group: Enzymes. Synonyms: FLICE2, Mch4; CASP-10; ICE-like apoptotic protease 4; apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1β-converting enzyme 2. Enzyme Commission Number: EC 3.4.22.63. CAS No. 189088-85-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4239; caspase-10; EC 3.4.22.63; 189088-85-5; FLICE2, Mch4; CASP-10; ICE-like apoptotic protease 4; apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1β-converting enzyme 2. Cat No: EXWM-4239. | |
| CAY10412 | Anandamide (AEA), also known as N-arachidonoylethanolamine, is an endogenous lipid with cannabinergic activity. CAY10412 is an analog of AEA that has no intrinsic binding affinity for either CB1 or CB2 receptors. It is a potent inhibitor of AEA reuptake in U937 lymphoma cells with IC50 of 3 μM. It could be a useful tool for distinguishing the competing transporter theories. CAY10412 may enhance endocannabinoid signalling by augmenting endocannabinoid concentrations. Synonyms: CAY 10412; CAY-10412. Grades: ≥98%. CAS No. 390824-17-6. Molecular formula: C25H36O2S. Mole weight: 400.6. | |
| CAY10561 | The extracellular signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 with Ki of 2 nM. It is highly selective for ERK2 and inhibits proliferation of COLO 205 cells with IC50 of 0.54 μM. Synonyms: Pyrazolylpyrrole ERK Inhibitor; CAY 10561; CAY-10561. Grades: ≥98%. CAS No. 933786-58-4. Molecular formula: C22H17Cl2FN4O2. Mole weight: 459.3. | |
| Chloroquine phosphate | Chloroquine phosphate is an antimalarial drug and weak intercalating agent. It inhibits TLR signalling in plasmacytoid dendritic cells (pDCs). It has been used in emergency of COVID-19. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt; Aralen diphosphate; C2301; C 2301; C-2301; Chloroquine Diphosphate. Grades: ≥98% (HPLC). CAS No. 50-63-5. Molecular formula: C18H32ClN3O8P2. Mole weight: 515.86. | |
| cyclic GMP-AMP synthase | Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines. Group: Enzymes. Synonyms: cGAMP synthase; cGAS. Enzyme Commission Number: EC 2.7.7.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3299; cyclic GMP-AMP synthase; EC 2.7.7.86; cGAMP synthase; cGAS. Cat No: EXWM-3299. | |
| Daucosterol | Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Eleutheroside A; β-Sitosterol β-D-glucoside. CAS No. 474-58-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N0410. | |
| Deltarasin hydrochloride | Small molecule inhibitor of the KRAS-PDEδ interaction that impairs oncogenic KRAS signalling by altering its localization to endomembranes (in cell Kd value 41 nM for deltarasin binding to PDEδ). Deltarasin suppresses in vitro and in vivo MAPK signaling and proliferation of human pancreatic ductal adenocarcinoma (PDAC) cells that are dependent on oncogenic KRAS. Synonyms: Deltarasin hydrochloride. Grades: >98%. CAS No. 1440898-82-7. Molecular formula: C40H38ClN5O. Mole weight: 640.22. | |
| Demethoxyviridiol | It is a mycotoxin produced by the strain of Nodulisporium hinnuleum. It is a fungal metabolite belonging to the wortmannin and viridin classes and an inhibitor of phosphatidylinositol 3-kinase. It affects phospholipid signalling and proliferation of swiss 3T3 cells. Synonyms: Desmethoxyviridiol; Cyclopenta(7,8)phenanthro(10,1-bc)furan-6,9-dione, 1,2,3,7,8,11b-hexahydro-1,3-dihydroxy-11b-methyl-, (1R-(1-alpha,3-alpha,11b-alpha))-; (1R,3S,11bR)-1,2,3,7,8,11b-Hexahydro-1,3-dihydroxy-11b-methylcyclopenta[7,8]phenanthro[10,1-bc]furan-6,9-dione; [1R-(1α,3α,11bα)]-1,2,3,7,8,11b-hexahydro-1,3-dihydroxy-11b-methylcyclopenta[7,8]phenanthro[10,1-bc]furan-6,9-dione. Grades: >95% by HPLC. CAS No. 56617-66-4. Molecular formula: C19H16O5. Mole weight: 324.33. | |
| diacylglycerol diphosphate phosphatase | The bifunctional enzyme catalyses the dephosphorylation of diacylglycerol diphosphate to phosphatidate and the subsequent dephosphorylation of phosphatidate to diacylglycerol (cf. phosphatidate phosphatase (EC 3.1.3.4)). It regulates intracellular levels of diacylglycerol diphosphate and phosphatidate, phospholipid molecules believed to play a signalling role in stress response. The phosphatase activity of the bifunctional enzyme is Mg2+-independent and N-ethylmaleimide-insensitive and is distinct from the Mg2+-dependent and N-ethylmaleimide-sensitive enzyme EC 3.1.3.4 (phosphatidate phosphatase).The diacylglycerol pyrophosphate phosphatase activity in Saccharomyces cerevisiae is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase. Group: Enzymes. Synonyms: DGPP phosphatase; DGPP phosphohydrolase; DPP1; DPPL1; DPPL2; PAP2; pyrophosphate phosphatase. Enzyme Commission Number: EC 3.1.3.81. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3687; diacylglycerol diphosphate phosphatase; EC 3.1.3.81; DGPP phosphatase; DGPP phosphohydrolase; DPP1; DPPL1; DPPL2; PAP2; pyrophosphate phosphatase. Cat No: EXWM-3687. | |
| diguanylate cyclase | A GGDEF-domain-containing protein that requires Mg2+ or Mn2+ for activity. The enzyme can be activated by BeF3, a phosphoryl mimic, which results in dimerization. Dimerization is required but is not sufficient for diguanylate-cyclase activity. Cyclic di-3',5'-guanylate is an intracellular signalling molecule that controls motility and adhesion in bacterial cells. It was first identified as having a positive allosteric effect on EC 2.4.1.12, cellulose synthase (UDP-forming). Group: Enzymes. Synonyms: DGC; PleD. Enzyme Commission Number: EC 2.7.7.65. CAS No. 146316-82-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3276; diguanylate cyclase; EC 2.7.7.65; 146316-82-7; DGC; PleD. Cat No: EXWM-3276. | |
| (±)-Equol | (R,S)-Equol is a flavonoid. Racemic mixture. This is a metabolite that is produced in vivo from soy phytoestrogen daidzein from gut microflora. (R,S)-Equol inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 signalling pathway. (R,S)-Equol shows positive effects on the incidence of prostate cancer. Functions as a DHT blocker. Preferentially activates estrogen receptor β (ERβ). Uses: Phytoestrogens. Synonyms: 3-(4-hydroxyphenyl)chroman-7-ol. Grades: ≥98%. CAS No. 94105-90-5. Molecular formula: C15H14O3. Mole weight: 242.3. | |
| Etigilimab | Etigilimab (OMP-313M32), a humanized IgG1 monoclonal antibody, blocks TIGIT interaction with PVR (CD155; poliovirus receptor) and inhibits downstream signalling with target cell killing [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: OMP-313M32. CAS No. 2044984-83-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99949. | |
| Fibroblast Growth Factor | Fibroblast Growth Factors are a family of cell signalling proteins produced by macrophages, consisting of 23 members in humans. They have various functions so that is involved in multiple processes, regulating fundamental developmental pathways. Synonyms: FGF. | |
| Geranylgeraniol | An intermediate in the lipidation of proteins, which plays a great importance for a variety of biological processes such as cell signalling. Synonyms: Tetraprenol; Geranyl geraniol; (E,E,E)-Geranylgeraniol; trans-Geranylgeraniol; 3,7,11,15-tetramethylhexadeca-2E,6E,10E,14-tetraen-1-ol. Grades: 85%. CAS No. 24034-73-9. Molecular formula: C20H34O. Mole weight: 290.48. | |
| GNE-6776 | GNE-6776 is a potent and non-covalent USP7 inhibitor with IC50 of 1.34 uM. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways, and induces tumor cell death. Synonyms: GNE 6776; GNE-6776; GNE6776; 5-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methyl-pyridine-2-carboxamide. Grades: 98%. CAS No. 2009273-71-4. Molecular formula: C20H20N4O2. Mole weight: 348.406. | |
| HC-5404-Fu | HC-5404-Fu is a PERK inhibitor with an antitumor activity. HC-5404-Fu inhibits endoplasmic reticulum stress response signalling. HC-5404-Fu sensitizes renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors ( TKIs ). HC-5404-Fu is promising for research of renal cell carcinoma, gastric cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3034479-99-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-157231A. | |
| Hetrombopag | Hetrombopag is an orally active human thrombopoietin receptor agonist. Hetrombopag protects Cardiomyocyte Survival from Oxidative Stress Damage as an Enhancer of Stem Cells. Hetrombopag specifically stimulated proliferation and/or differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells, with low nanomolar EC50 values through stimulation of STAT, PI3K and ERK signalling pathways. Notably, hetrombopag effectively up-regulated G1 -phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalized progression of the cell cycle, and prevented apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Group: Agonists. Alternative Names: SHR8735; SHR 8735; SHR-8735; Hetrombopag. CAS No. 1257792-41-8. Molecular formula: C25H22N4O5. Mole weight: 458.47. Appearance: Solid powder. Purity: >98%. IUPACName: (E)-5-(2-hydroxy-3-(2-(3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)phenyl)furan-2-carboxylic acid. Canonical SMILES: O=C (C1=CC=C (C2=CC=CC (N/N=C3C (N (C4=CC=C5CCCCC5=C4) N=C/3C) =O) =C2O) O1) O. Catalog: ACM1257792418. | |
| Homoplantaginin | Homoplantaginin is a flavonoid glycoside found in Scoparia dulcis. Homoplantaginin ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway, suggesting it may be used for the prevention and treatment of endothelial dysfunction associated with insulin resistance. Synonyms: 5-hydroxy-2-(4-hydroxyphenyl)-6-methoxy-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside. Grades: >98%. CAS No. 17680-84-1. Molecular formula: C22H22O11. Mole weight: 462.4. | |
| IQ 1 | IQ 1 is a Wnt/β-catenin/CBP signalling sustainer. IQ 1 maintains long-term expansion of Wnt/β-catenin -driven mouse embryonic stem cells (ESCs) and prevents spontaneous differentiation by enhancing β-catenin/CBP -mediated transcription and preventing conversion to β-catenin/p300 -mediated transcription. IQ-1 regulates Wnt signalling by interacting with PR72/130. IQ 1 can be used in study of ESCs expansion [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 331001-62-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10593. | |
| KP372-1 | KP372-1 is a synthetic small molecule AKT inhibitor. KP372-1 is consisted of two isomers: KP372-1A and KP372-1B. KP372-1 showed activities to block signalling downstream of Akt in thyroid tumour cells, leading to inhibition of cell proliferation and increased apoptosis. KP372-1 has also been shown to suppress cell proliferation and induce apoptosis in gliobastoma. Synonyms: KP 372-1; indeno[2,3-e]1,2,3,4-tetraazolo[1,5-b]1,2,4-triazin-10-one; 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one. CAS No. 329710-24-9. Molecular formula: C10H4N6O. Mole weight: 224.18. | |
| Leukadherin-1 | Leukadherin-1, also known as LA1, is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1. Leukadherin-1 suppresses human innate inflammatory signalling. leukadherin-1 increases CD11b/CD18-dependent adhesion via membrane tethers. It also competitively inhibits YopH (Ki = 1.94 μM), a tyrosine phosphorylase secreted by Y. pestis into immune cells to block signal transduction, and anthrax lethal factor metalloproteinase, a component of anthrax toxin (IC50 = 6 μM). Synonyms: 4-[5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid; Leukadherin-1; Leukadherin 1; Leukadherin1; LA1. CAS No. 344897-95-6. Molecular formula: C22H15NO4S2. Mole weight: 421.48. | |
| MS-1020 | MS-1020 is a selective, cell-permeable inhibitor of Janus kinase 3 (JAK3). It potently inhibited persistently-active STAT3 in a cell type-specific manner, and consistently suppressed interleukin-2-induced JAK3/STAT5 signalling. Synonyms: MS 1020; MS1020; 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]naphthalene-2-carboxamide. Grades: ≥95%. CAS No. 1255516-86-9. Molecular formula: C21H18N2O3. Mole weight: 346.4. | |
| Naltrexone | Naltrexone is an antagonist of Opioid receptor. Naltrexone inhibits cell proliferation in vivo. Naltrexone reduces tumor growth by interfering with cell signalling and modifying the immune system [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 16590-41-3. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-76711. | |
| Native Escherichia coli Diacylglycerol Kinase | Diacylglycerol kinase (DGK or DAGK) is a family of enzymes that catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA) utilizing ATP as a source of the phosphate. In non-stimulated cells, DGK activity is low allowing DAG to be used for glycerophospholipid biosynthesis but on receptor activation of the phosphoinositide pathway, DGK activity increases driving the conversion of DAG to PA. As both lipids are thought to function as bioactive lipid signaling molecules with distinct cellular targets, DGK therefore occupies an important position, effectively serving as a switch by terminating the signalling of one lipid while simultaneously activating signa...n of dgka and plsb genes of phospholipid synthesis by multiple stress responses in escherichia coli. diacylglycerol kinase from escherichia coli has also been used in a study to identify an alcohol binding site in the first cysteine-rich domain of protein kinase cdelta. Group: Enzymes. Synonyms: Diacylglycerol Kinase; DGK; DAGK; EC 2.7.1.107; Diacylglycerol kinase (ATP); sn-1,2-Diacylglycerol kinase. Enzyme Commission Number: EC 2.7.1.107. CAS No. 60382-71-0. DAGK. Mole weight: mol wt 13.7 kDa. Stability: -70°C. Form: suspension. Source: E. coli. Diacylglycerol Kinase; DGK; DAGK; EC 2.7.1.107; Diacylglycerol kinase (ATP); sn-1,2-Diacylglycerol kinase. Cat No: NATE-0181. | |
| Pepinemab | Pepinemab (VX 15/2503) is a human monoclonal antibody against SEMA4D, a signalling protein 4D (SEMA4D), also known as CD100, which is a regulator of neuronal development and plays a role in a variety of cellular processes. Pepinemab can be used in the study of various neurodegenerative diseases such as Alzheimer's disease by blocking the activity of SEMA4D [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: VX 15/2503. CAS No. 2097151-87-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99407. | |
| protein kinase C | A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters. Group: Enzymes. Synonyms: calcium-dependent protein kinase C; calcium-independent protein kinase C; calcium/phospholipid dependent protein kinase; cPKCα; cPKCβ; cPKCγ; nPKCΔ; nPKCε; nPKC; nPKC; PKC; PKCα; PKCβ; PKCγ; PKCΔ; PKCε; PKCζ; Pkc1p; protein kinase Cε; STK24. Enzyme Commission Number: EC 2.7.11.13. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3132; protein kinase C; EC 2.7.11.13; calcium-dependent protein kinase C; calcium-independent protein kinase C; calcium/phospholipid dependent protein kinase; cPKCα; cPKCβ; cPKCγ; nPKCΔ; nPKCε; nPKC; nPKC; PKC; PKCα; PKCβ; PKCγ; PKCΔ; PKCε; PKCζ; Pkc1p; protein kinase Cε; STK24. Cat No: EXWM-3132. | |
| quorum-quenching N-acyl-homoserine lactonase | Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a processknown as quorum-sensing. Each bacterial cell has a basal level of AHL and, once thepopulation density reaches a critical level, it triggers AHL-signalling which, in turn,initiates the expression of particular virulence genes.Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria. N-(3-Oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L-homoserine lactone, ...7-43-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3510; quorum-quenching N-acyl-homoserine lactonase; EC 3.1.1.81; 389867-43-0; acyl homoserine degrading enzyme; acyl-homoserine lactone acylase; AHL lactonase; AHL-degrading enzyme; AHL-inactivating enzyme; AHLase; AhlD; AhlK; AiiA; AiiA lactonase; AiiA-like protein; AiiB; AiiC; AttM; delactonase; lactonase-like enzyme; N-acyl homoserine lactonase; N-acyl homoserine lactone hydrolase; N-acyl-homoserine lactone lactonase; N-acyl-L-homoserine lactone hydrolase; quorum-quenching lactonase; quorum-quenching N-acyl homoserine lactone h | |
| receptor protein serine/threonine kinase | The transforming growth factor β (TGF-β) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-β is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. Group: Enzymes. Synonyms: activin receptor kinase; receptor type I serine/threonine protein kinase; receptor type II serine/threonine protein kinase; STK13; TGF-β kinase; receptor serine/threonine protein kinase. Enzyme Commission Number: EC 2.7.11.30. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3151; receptor protein serine/threonine kinase; EC 2.7.11.30; activin receptor kinase; receptor type I serine/threonine protein kinase; receptor type II serine/threonine protein kinase; STK13; TGF-β kinase; receptor serine/threonine protein kinase. Cat No: EXWM-3151. | |
| rhomboid protease | These endopeptidases are multi-spanning membrane proteins. Their catalytic site is embedded within the membrane and they cleave type-1 transmembrane domains. A catalytic dyad is involved in proteolysis rather than a catalytic triad, as was thought previously. They are important for embryo development in Drosophila melanogaster. Rhomboid is a key regulator of EGF receptor signalling and is responsible for cleaving Spitz, the main ligand of the Drosophila EGF receptor pathway. Belongs in peptidase family S54. Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite. Rhomboids are widely conserved from bacteria to archaea to humans. Group: Enzymes. Enzyme Commission Number: EC 3.4.21.105. CAS No. 713145-02-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4100; rhomboid protease; EC 3.4.21.105; 713145-02-9. Cat No: EXWM-4100. | |
| Sp-8-BnT-2'-O-Me-cAMPS / "S-223" | Sp-8-BnT-2'-O-Me-cAMPS is the most potent 2'-substituted activator of Epac2. In human osteosarcoma U2OS cell lines expressing Epac1 or Epac2, Sp-8-BnT-2'-O-Me-cAMPS does not induce Epac signalling at 100 μM possibly for inefficient cellular uptake in this biosystem. Synonyms: 8- Benzylthio- 2'- O- methyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 98% by HPLC. Molecular formula: C18H19N5O5PS2 · Na. Mole weight: 503.5. | |
| sphingomyelin synthase | The reaction can occur in both directions. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin. Group: Enzymes. Synonyms: SM synthase; SMS1; SMS2. Enzyme Commission Number: EC 2.7.8.27. CAS No. 58703-97-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3326; sphingomyelin synthase; EC 2.7.8.27; 58703-97-2; SM synthase; SMS1; SMS2. Cat No: EXWM-3326. | |
| TD52 | TD52, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity [1]. TD52 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1798328-24-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135699. | |
| Tetromycin A | Tetromycin A is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. Tetromycin A has pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA. Limited availability has restricted further investigation of this metabolite in the literature. Several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'- kinase/Akt signalling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 180027-83-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Tetromycin B | Tetromycin B is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. Tetromycin B has pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA. Limited availability has restricted further investigation of this metabolite in the literature. Several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'- kinase/Akt signalling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 180027-84-3. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Tricirbine | Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3. It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 μM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day. Synonyms: VQD-002; VQD 002; VQD002; NSC-154020; NSC 154020; NSC154020; Triciribine; TCN-P; triciribine; Tricyclic nucleoside; Pentaazacentopthylene; API-2; Akt Inhibitor V. Grades: 99.81%. CAS No. 35943-35-2. Molecular formula: C13H16N6O4. Mole weight: 320.309. | |
| ZAP-70 Tyrosine Kinase human, Recombinant | ZAP-70 is protein tyrosine kinase of the Syk family that is localized exclusively to the cytosol of T cells and natural killer cells. It is required for T cell activation. It is activated by Lck-mediated phosphorylation of its tyrosine residues. ZAP-70 Tyrosine Kinase is a protein belongs to Syk family and is essential for T cell activation. It facilitates the upregulation of Fas ligand in activation-induced T cell apoptosis. Additionally, it also plays a pivotal role in LFA-1-dependent T Cell Migration. > 90% (sds-page), recombinant, expressed in baculovirus infected insect cells (histidine tagged), buffered aqueous glycerol solution, > 150 u/mg. Applications: Human zap-70 tyrosine kinase was used for mapping the phosphorylation sites on lat (linker for activation of t cells) for investigating the mechanism of activation of signalling proteins in t cells. Group: Enzymes. Synonyms: ZAP-70 Tyrosine Kinase; Zeta-chain-associated protein kinase 70; ZAP-70; SRK; STCD; STD; TZK; ZAP70. Purity: > 90% (SDS-PAGE). ZAP70. Mole weight: mol wt 70 kDa. Activity: > 150 U/mg. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: baculovirus infected insect cells (Histidine tagged). Species: Human. ZAP-70 Tyrosine Kinase; Zeta-chain-associated protein kinase 70; ZAP-70; SRK; STCD; STD; TZK; ZAP70. Cat No: NATE-0738. | |
| ZD-4190 | ZD-4190, a substituted 4-anilinoquinazoline, is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, with broad-spectrum antitumor efficacy. ZD-4190 is one of a series of VEGF RTK inhibitors that may have utility in the treatment of a range of histologically diverse solid tumor types. Synonyms: ZD-4190; ZD 4190; ZD4190. CAS No. 413599-62-9. Molecular formula: C19H16BrFN6O2. Mole weight: 459.27. | |
| 08:0 PI Ammonium salt | Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival. Synonyms: 1,2-dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol) (ammonium salt); (R)-2, 3-bis(octanoyloxy)propyl((1S, 2R, 3R, 4S, 5S, 6R)-2, 3, 4, 5, 6-pentahydroxycyclohexyl) phosphate ammonium salt; PI(8:0/8:0). Grades: >99%. CAS No. 2260795-76-2. Molecular formula: C25H50NO13P. Mole weight: 603.64. | |
| 10-Gingerol | 10-Gingerol is an AMPK agonist, which is found in the ginger oleoresin from fresh rhizome with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. 10-Gingerol exhibits substantial scavenging activities with an IC 50 value of 10.47 μM against DPPH radical, an IC 50 value of 1.68 μM against superoxide radical and an IC 50 value of 1.35 μM against hydroxyl radical. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC 50 of 12.1 μM. 10-Gingerol suppresses the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. 10-Gingerol is promising for research of ulcerative colitis [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 23513-15-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N0448. | |
| 10-Hydroxydecanoic Acid | 10-Hydroxydecanoic Acid plays a crucial role in the cellular signal transduction in immune responses. Modulates innate immune response affecting the toll-like receptors (TLRs) which play a crucial role in the immunity and recognizing pathogen associated molecular patterns. Group: Biochemicals. Grades: Highly Purified. CAS No. 1679-53-4. Pack Sizes: 1g, 5 g. Molecular Formula: C10H20O3. US Biological Life Sciences. | Worldwide |
| 11,12-EET | 11,12-EET is a cytochrome P450-derived molecule that is reported to inhibit the epithelial sodium channel (ENaC). It is also reported to be involved in the recovery of Ca2+ pool-depleted cells as sustained increases in EETs may amplify Ca2+ signaling. Group: Biochemicals. Alternative Names: 11,12-epoxyeicosatrienoic acid, 11,12-Eet, 11,12-epoxy-5,8,14-eicosatrienoic acid, 11,12-Oxido-5,8,14-eicosatrienoic acid, 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid. Grades: Highly Purified. CAS No. 123931-40-8. Pack Sizes: 100ug. Molecular Formula: C20 H32 O3, Molecular Weight: 320.5. US Biological Life Sciences. | Worldwide |
| 11alpha-Hydroxyprogesterone | 11alpha-Hydroxyprogesterone is the analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase ; also activates human mineralocorticoid receptor in COS-7 cells with an ED 50 of 10 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 80-75-1. Pack Sizes: 25 mg; 50 mg. Product ID: HY-W011243. | |
| 1,2,3,6-Tetra-O-methyl-D-glucopyranoside | 1,2,3,6-Tetra-O-methyl-D-glucopyranoside - a synthetic biochemical agent - is extensively employed in contemporary cell culture investigations as a non-metabolizable glucose analogue. Through cellular signaling observation, this agent permits a comprehensive evaluation of glucose transport in relation to metabolism, thereby advancing our insight on its dependence. Besides, owing to its saccharide structure, 1,2,3,6-Tetra-O-methyl-D-glucopyranoside represents an appropriate substrate for glycosidase enzyme assays - identifying and gauging the enzymes activities. Molecular formula: C10H20O6. Mole weight: 236.26. | |
| 1,2:5,6-Di-O-isopropylidene-3,4-di-O-benzyl-D-myo-inositol | 1,2:5,6-Di-O-isopropylidene-3,4-di-O-benzyl-D-myo-inositol, a chemical compound indispensable in various syntheses of inositol phosphates, exhibits profound implications in cell signaling pathways, making it a promising candidate for cancer therapy and other diseases. With its intricate chemical structure and diverse molecular properties, it imbues the inositol phosphates with their unique functionalities. Molecular formula: C26H32O6. Mole weight: 440.53. | |
| 1,2-Dipalmitoyl phosphatidylinositol 4-phosphate ammonium salt | 1,2-Dipalmitoyl phosphatidylinositol 4-phosphate ammonium salt, a vital phospholipid derivative in signaling pathways associated with immune response and inflammation. This molecule has a multifaceted role, demonstrated by its ability to alter TNF-α activity and regulate T cell activation. Its therapeutic potential extends to autoimmune and inflammatory afflictions; hence, creating an opportunity to target treatments for arthritis and asthma. Synonyms: L-a-Phosphatidyl-(12-dipalmitoyl)-D-myo-inositol 4-monophosphate. CAS No. 57606-15-2. Molecular formula: C41H80O16P2. Mole weight: 891.01. | |
| 1,2-Dipalmitoyl phosphatidylinositol 5-phosphate | 1,2-Dipalmitoyl phosphatidylinositol 5-phosphate is a pivotal phospholipid, involving in intricate signaling pathways governing diverse cellular mechanisms.Its research applications encompass the exploration of lipid metabolism, membrane trafficking, and dynamic cell membrane characteristics. Synonyms: 1,2-dipalmitoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate); [ (2R) -2-hexadecanoyloxy-3- [hydroxy- [ (1R, 2R, 3R, 4R, 5S, 6R) -2, 3, 4, 6-tetrahydroxy-5-phosphonooxycyclohexyl] oxyphosphoryl] oxypropyl] hexadecanoate; L-alpha-Phosphatidyl-D-myo-inositol 5-monophosphate, dipalmitoyl; PtdIns(5)P; 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate); PtdIns(5)P1; D-myo-PI[5]P; PI5P; PI[5]P;D-myo-Phosphatidylinositol 5-phosphate (PtdIns(5)P); Q27158617; D-myo-Inositol 5-monophosphate, L- alpha -Phosphatidyl-(1,2-dipalmitoyl); D-myo-Inositol 5-monophosphate, L-alpha-Phosphatidyl-(1,2-dipalmitoyl). CAS No. 291527-75-8. Molecular formula: C41H80O16P2. Mole weight: 891.01. | |
| 12-HETE | 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway [1].12-HETE has both anti-thrombotic and pro-thrombotic effects [2]. 12-HETE is a neuromodulator [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 71030-37-0. Pack Sizes: 50 μg (312.04 μM * 0.5 mL in Ethanol); 100 μg (312.04 μM * 1 mL in Ethanol). Product ID: HY-113439. | |
| 1,2-Naphthoquinone (90%) | 1,2-Naphthquinone is a highly reactive quinone species which aids in modulating cellular homeostasis and electrophilic signal transduction pathways. Group: Biochemicals. Grades: Highly Purified. CAS No. 524-42-5. Pack Sizes: 1g, 2.5g. Molecular Formula: C10H6O2. US Biological Life Sciences. | Worldwide |
| 12-Oxo phytodienoic acid | 12-Oxo phytodienoic acid (12-OPDA) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid suppresses neuroinflammation by inhibiting Nf-κB and p38 MAPK signaling in LPS-activated cells. 12-Oxo phytodienoic acid can be used for neurodegenerative diseases research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 12-OPDA. CAS No. 85551-10-6. Pack Sizes: 100 μg (3.42 mM * 100 μL in Ethanol). Product ID: HY-118828. | |
| 1,3,4,6-Tetra-O-acetyl-2-deoxy-2-iodo-a-D-glucopyranose | 1,3,4,6-Tetra-O-acetyl-2-deoxy-2-iodo-α-D-glucopyranose, a pivotal compound extensively employed in the biomedical sector, exhibits remarkable structural attributes. It finds widespread application in the fabrication of groundbreaking medicinal compounds. The iodine substitution within this compound enables its utilization as an indispensable radiolabeling agent, facilitating cutting-edge diagnostic imaging practices. Moreover, it assumes a crucial role in investigating the intricate mechanisms underlying carbohydrate metabolism and the cell signaling pathways implicated in diverse pathological conditions. Synonyms: 1,3,4,6-Tetra-O-acetyl-2-deoxy-2-iodo-D-glucopyranose; 2-DEOXY-2-IODO-1,3,4,6-TETRA-O-ACETYL--D-GLUCOPYRANOSE; [(2R,3R,4S,5R)-3,4,6-triacetyloxy-5-iodooxan-2-yl]methyl acetate; SCHEMBL14376661; DTXSID00723500. CAS No. 95672-63-2. Molecular formula: C14H19IO9. Mole weight: 458.20. | |
| 1400W Dihydrochloride | 1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase ( iNOS ) inhibitor, with a K d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 214358-33-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18731. | |
| 14-3-3η Protein inhibitor 1 | 14-3-3η Protein inhibitor 1 (Compound C11) is a 14-3-3η protein inhibitor with a K D of 35 μM. 14-3-3η Protein inhibitor 1 shows inhibitory activities against several typical human liver cancer cell lines. 14-3-3η Protein inhibitor 1 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2770842-10-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-146302. | |
| 1,4-Anthraquinone | 1,4-Anthraquinone is a potent anticancer agent. 1,4-Anthraquinone blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of cancer cells. 1,4-Anthraquinone can be used to research anti-leukemia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 635-12-1. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W077242. | |
| 1-(5-Carboxypentyl)-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate | 1-(5-Carboxypentyl)-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate, a highly sought-after fluorescent probe, has gained immense popularity in biomedical research due to its ability to detect minute cellular anomalies associated with cancer and other life-threatening diseases. Its application extends beyond its diagnostic potential and is frequently utilized in drug discovery initiatives aimed at identifying novel therapeutics that target specific and often elusive signaling pathways involved in disease progression. Its remarkable attributes and versatility have made it an indispensable tool in the ever-expanding realm of medical research. Synonyms: 1-(5-carboxypentyl)-2,3,3-trimethyl-3H-indolium-5-sulfonate (IM OCS). CAS No. 146368-08-3. Molecular formula: C17H23NO5S. Mole weight: 353.4. | |
| 15-deoxy-Δ12,14-Prostaglandin D2 | 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2 (HY-101988), is an agonist of prostaglandin receptor 2 (DP2). 15-deoxy-Δ12,14-Prostaglandin D2 binds to DP2 (Ki=50 nM) and induces eosinophil activation ( EC 50 =8 nM). 15-deoxy-Δ12,14-Prostaglandin D2 also stimulates the recruitment of steroid receptor coactivator-1 ( SRC-1 ) to peroxisome proliferator-activated receptor γ ( PPARγ ), inducing PPARγ-mediated transcription. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is cytotoxic to L1210 murine leukemia cells ( IC 50 =0.3 μg/ml) and inhibits ADP-induced platelet aggregation ( IC 50 =320 ng/mL). Uses: Scientific research. Group: Signaling pathways. Alternative Names: 15-Deoxy-Δ12,14-PGD2. CAS No. 85235-11-6. Pack Sizes: 1 mg (2.99 mM * 1 mL in Methyl acetate). Product ID: HY-116028. | |
| 15(S)-HPETE | 15(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A41 or reduced to 15(S)-HETE by peroxidases.2,1 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1.3 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inactivation of porcine 12-LO. Uses: Scientific research. Group: Signaling pathways. CAS No. 70981-96-3. Pack Sizes: 25 μg (297.20 μM * 250 μL in Ethanol). Product ID: HY-113438. | |
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