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| Product | Description | |
|---|---|---|
| CGRP (83-119), rat TFA | Calcitonin Gene Related Peptide (CGRP) (83-119), rat acts through calcitonin receptor-like receptor. Synonyms: Calcitonin Gene Related Peptide(83-119), rat TFA. Molecular formula: C162H262N50O52S2.C2HF3O2. Mole weight: 3920.32. |  |
| CGRP 8-37 (human) | CGRP 8-37 (human). Group: Biochemicals. Grades: Purified. CAS No. 119911-68-1. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| CGRP 8-37 (human) | CGRP 8-37 (human) is a peptide antagonist for CGRP1 receptors. Uses: Miotics. Synonyms: FBHuman; HCGRP-(8-37); HY-P1014; HY P1014; HYP1014; CGRP 8 37. Grade: >95%. CAS No. 119911-68-1. Molecular formula: C139H230N44O38. Mole weight: 3125.6. | |
| CGRP 8-37 (rat) | CGRP 8-37 (rat). Group: Biochemicals. Grades: Purified. CAS No. 129121-73-9. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| CGRP antagonist 1 | CGRP antagonist 1 is a highly potent antagonist of CGRP receptor (Ki = 35 nM; IC50 = 57 nM). Synonyms: (S)-N-(2''-oxo-1,1'',2'',3-tetrahydrospiro[indene-2,3''-pyrrolo[2,3-b]pyridine]-5-yl)-2-(2-oxo-2'',3'',5'',6''-tetrahydrospiro[indoline-3,4''-pyran]-1-yl)acetamide; Spiro[3H-indole-3,4'-[4H]pyran]-1(2H)-acetamide, 2',3',5',6'-tetrahydro-2-oxo-N-[(2S)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-; N-[(2S)-2'-Oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl]-2-(2-oxo-2',3',5',6'-tetrahydrospiro[indole-3,4'-pyran]-1(2H)-yl)acetamide. Grade: ≥95%. CAS No. 1123757-49-2. Molecular formula: C29H26N4O4. Mole weight: 494.54. | |
| CGRP (rat) | α-CGRP (rat) is an endogenous neuropeptide displaying vasodilator, cardiovascular, pro-inflammatory and metabolic effects. Synonyms: Calcitonin Gene-Related Peptide (rat). Grade: >95%. CAS No. 83651-90-5. Molecular formula: C162H262N50O52S2. Mole weight: 3806.3. | |
| CGRP (rat) | CGRP (rat). Group: Biochemicals. Grades: Purified. CAS No. 83651-90-5. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Alpha-cgrp(29-37)(canine,mouse,rat) | Alpha-cgrp(29-37)(canine,mouse,rat). Uses: Designed for use in research and industrial production. Additional or Alternative Names: 219991-19-2. Product Category: Heterocyclic Organic Compound. CAS No. 219991-19-2. Molecular formula: C40H61N11O14. Mole weight: 919.977640 [g/mol]. Purity: 0.96. IUPACName: (4S)-4-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-3-hydroxy-2-[[(2S)-pyrrolidine-2-carbonyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-5-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl. Canonical SMILES: CC(C)C(C(=O)NCC(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(C(C)O)NC(=O)C2CCCN2. Product ID: ACM219991192. Alfa Chemistry ISO 9001:2015 Certified. Categories: a-CGRP (29-37) (canine. |  |
| Alpha-cgrp(32-37)(canine,mouse,porcine,rat) | Alpha-cgrp(32-37)(canine,mouse,porcine,rat). Uses: Designed for use in research and industrial production. Additional or Alternative Names: 132917-48-7. Product Category: Heterocyclic Organic Compound. CAS No. 132917-48-7. Molecular formula: C27H41N7O9. Mole weight: 607.655940 [g/mol]. Purity: 0.96. IUPACName: (4S)-4-[[(2S)-2-[[2-[[(2S)-2-amino-3-methylbutanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-5-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid. Canonical SMILES: CC(C)C(C(=O)NCC(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)N)N. Product ID: ACM132917487. Alfa Chemistry ISO 9001:2015 Certified. | |
| Alpha-cgrp(canine,mouse,rat) | Alpha-cgrp(canine,mouse,rat). Uses: Designed for use in research and industrial production. Additional or Alternative Names: alpha-CGRP (canine, mouse, rat);a-CGRP (rat). Product Category: Heterocyclic Organic Compound. CAS No. 83651-90-5. Molecular formula: C162H262N50O52S2. Product ID: ACM83651905. Alfa Chemistry ISO 9001:2015 Certified. | |
| α-CGRP (human) | α-CGRP (human) is an endogenous calcitonin gene-related peptide receptor (CGRP) agonist. Synonyms: Calcitonin Gene Related Peptide; CGRP, human. CAS No. 90954-53-3. Molecular formula: C163H267N51O49S2. Mole weight: 3789.33. | |
| α-CGRP(human) | α-CGRP(human) (Calcitonin gene-related peptide) is a regulatory neuropeptide of 37 amino acids. α-CGRP(human) is widely distributed in the central and peripheral nervous system. α-CGRP(human) is a potent vasodilator and has inotropic and chronotropic effects [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: Calcitonin gene-related peptide. CAS No. 90954-53-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1071. |  |
| α-CGRP (human) TFA | α-CGRP (human) is an endogenous calcitonin gene-related peptide receptor (CGRP) agonist. Synonyms: Calcitonin Gene Related Peptide (TFA); CGRP, human (TFA). Molecular formula: C163H267N51O49S2 (free base). Mole weight: 3789.33 (free base). | |
| α-CGRP (mouse, rat) | ?-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. ?-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. ?-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies[1][2][3][4]. Uses: Scientific research. Group: Peptides. Alternative Names: CGRP (83-119), mouse, rat. CAS No. 83651-90-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0203. | |
| β-CGRP, human | β-CGRP, human (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC 50 s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Human β-CGRP; CGRP-II (Human). CAS No. 101462-82-2. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P1548. | |
| β-CGRP, human | β-CGRP, human is a highly effective vasodilator. Synonyms: H-Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide bridge: Cys2-Cys7); Human β-CGRP; CGRP-II (Human); Calcitonin Gene Related Peptide II, human; α-Calcitonin gene-related peptide (human), 3-L-asparagine-22-L-methionine-25-L-serine-; β-Calcitonin gene-related peptide (human); L-Alanyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-valyl-L-threonyl-L-histidyl-L-arginyl-L-leucyl-L-alanylglycyl-L-leucyl-L-leucyl-L-seryl-L-arginyl-L-serylglycylglycyl-L-methionyl-L-valyl-L-lysyl-L-seryl-L-asparaginyl-L-phenylalanyl-L-valyl-L-prolyl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-lysyl-L-alanyl-L-phenylalaninamide cyclic (2→7)-disulfide; Human beta calcitonin gene-related peptide; Human calcitonin gene-related peptide 2; Human calcitonin gene-related peptide β; Human calcitonin gene-related peptide-II; Human calcitonin-related peptide II; Human β-calcitonin gene-related peptide. Grade: 95%. CAS No. 101462-82-2. Molecular formula: C162H267N51O48S3. Mole weight: 3793.35. | |
| β-CGRP, human acetate | β-CGRP, human acetate, is a calcitonin peptide that acts through a complex of receptor-activity-modifying protein (RAMP) and calcitonin receptor-like receptor (CRLR) with IC50s of 1 and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells, respectively. Synonyms: H-Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2.CH3CO2H (Disulfide bridge: Cys2-Cys7); L-alanyl-L-cysteinyl-L-asparagyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-valyl-L-threonyl-L-histidyl-L-arginyl-L-leucyl-L-alanyl-glycyl-L-leucyl-L-leucyl-L-seryl-L-arginyl-L-seryl-glycyl-glycyl-L-methionyl-L-valyl-L-lysyl-L-seryl-L-asparagyl-L-phenylalanyl-L-valyl-L-prolyl-L-threonyl-L-asparagyl-L-valyl-glycyl-L-seryl-L-lysyl-L-alanyl-L-phenylalaninamide (2->7)-disulfide acetate. Grade: ≥95%. Molecular formula: C164H271N51O50S3. Mole weight: 3853.46. | |
| β-CGRP, human TFA | β-CGRP, human TFA is one of the calcitonin peptide, through complex behavior of calcitonin receptor like receptor (CRLR) and receptor activity modifying proteins (increased), and 1 and 300 nM CRLR IC50s/RAMP1 and CRLR/RAMP2 cells. Synonyms: 3-L-asparagine-22-L-methionine-25-L-serine-alpha-calcitoningene-relatedpeptide (human), trifluoroacetate salt; Human β-CGRP (TFA); CGRP-II (Human) (TFA). Molecular formula: C164H268F3N51O50S3. Mole weight: 3907.38. | |
| Biotinyl-α-CGRP (human) | Biotinyl-α-CGRP (human). Synonyms: Biotinyl-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide bridge: Cys2-Cys7). Grade: ≥95% by HPLC. CAS No. 1816258-60-2. Molecular formula: C173H281N53O51S3. Mole weight: 4015.66. | |
| Biotinyl-α-CGRP (mouse, rat) | Biotinyl-α-CGRP (mouse, rat). Synonyms: Biotinyl-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge: Cys2-Cys7). Grade: ≥95% by HPLC. CAS No. 1816258-61-3. Molecular formula: C172H276N52O54S3. Mole weight: 4032.53. | |
| Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA | α-CGRP (rat) TFA, a member of the calcitonin neuropeptide family, contains 37 amino acids and is an endogenous neuropeptide with vasodilation, cardiovascular, pro-inflammatory and metabolic effects. Synonyms: Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2.TFA (Disulfide bridge: Cys2-Cys7); CGRP-1 (rat) TFA; L-seryl-L-cysteinyl-L-asparagyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-valyl-L-threonyl-L-histidyl-L-arginyl-L-leucyl-L-alanyl-glycyl-L-leucyl-L-leucyl-L-seryl-L-arginyl-L-seryl-glycyl-glycyl-L-valyl-L-valyl-L-lysyl-L-alpha-aspartyl-L-asparagyl-L-phenylalanyl-L-valyl-L-prolyl-L-threonyl-L-asparagyl-L-valyl-glycyl-L-seryl-L-alpha-glutamyl-L-alanyl-L-phenylalaninamide (2->7)-disulfide trifluoroacetic acid; α-CGRP (rat) TFA. Grade: >98%. Molecular formula: C162H262N50O52S2.C2HF3O2. Mole weight: 3920.32. | |
| HCGRP-(8-37) | HCGRP-(8-37) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP receptor. Uses: Scientific research. Group: Peptides. Alternative Names: Human ?-CGRP (8-37). CAS No. 119911-68-1. Pack Sizes: 500 ?g; 1 mg; 5 mg; 10 mg. Product ID: HY-P1014. | |
| HCGRP-(8-37) acetate | HCGRP-(8-37) acetate is the human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP1 receptors. Synonyms: H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2.CH3CO2H; L-valyl-L-threonyl-L-histidyl-L-arginyl-L-leucyl-L-alanyl-glycyl-L-leucyl-L-leucyl-L-seryl-L-arginyl-L-seryl-glycyl-glycyl-L-valyl-L-valyl-L-lysyl-L-asparagyl-L-asparagyl-L-phenylalanyl-L-valyl-L-prolyl-L-threonyl-L-asparagyl-L-valyl-glycyl-L-seryl-L-lysyl-L-alanyl-L-phenylalaninamide acetic acid; Human alpha-CGRP (8-37) acetate; 8-37-α-Calcitonin gene-related peptide (human) acetate; Human calcitonin gene-related peptide (8-37) acetate; Human CGRP(8-37) acetate; Human α-calcitonin gene-related peptide(8-37) acetate; Human α-CGRP (8-37) acetate. Grade: ≥95%. Molecular formula: C141H234N44O40. Mole weight: 3185.64. | |
| Rat CGRP-(8-37) | CGRP 8-37 (rat) is a peptide antagonist for CGRP1 receptors. Synonyms: Calcitonin Gene-Related Peptide 8-37 (rat); 8-37-a-Calcitoningene-related peptide (human reduced), 25-L-aspartic acid, 35-L-glutamic acid-; Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2; CGRP 8-37 rat; L-valyl-L-threonyl-L-histidyl-L-arginyl-L-leucyl-L-alanyl-glycyl-L-leucyl-L-leucyl-L-seryl-L-arginyl-L-seryl-glycyl-glycyl-L-valyl-L-valyl-L-lysyl-L-alpha-aspartyl-L-asparagyl-L-phenylalanyl-L-valyl-L-prolyl-L-threonyl-L-asparagyl-L-valyl-glycyl-L-seryl-L-alpha-glutamyl-L-alanyl-L-phenylalaninamide. Grade: ≥95%. CAS No. 129121-73-9. Molecular formula: C138H224N42O41. Mole weight: 3127.51. | |
| Rat CGRP-(8-37) | Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist. Uses: Scientific research. Group: Peptides. CAS No. 129121-73-9. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P0209. | |
| (Tyr27)-α-CGRP (27-37) (canine, mouse, rat) | (Tyr27)-α-CGRP (27-37) (canine, mouse, rat) is an empirically synthesized and selectively constructed peptide, epitomizing a conspicuous fragment of Calcitonin Gene-Related Peptide (CGRP). Synonyms: [Tyr0] Calcitonin Gene Related Peptide (28-37), rat; H-Tyr-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2; L-tyrosyl-L-valyl-L-prolyl-L-threonyl-L-asparagyl-L-valyl-glycyl-L-seryl-L-alpha-glutamyl-L-alanyl-L-phenylalaninamide. Grade: 95%. CAS No. 124501-79-7. Molecular formula: C54H79N13O17. Mole weight: 1182.28. | |
| 1,4-Bipiperidine | 1,4-Bipiperidine is used in the synthesis of selective sphingosine kinase 1 inhibitors used as a therapeutic agent for proliferative diseases. Also used in the synthesis of calcitonin gene-related (CGRP) receptor antagonists. Group: Biochemicals. Alternative Names: 4-(1-Piperidino)piperidine. Grades: Highly Purified. CAS No. 4897-50-1. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 1-L-Serine-3-L-asparagine-25-L-aspartic acid-35-L-glutamic acid-α-calcitonin gene-related peptide (human reduced) | It is a specific form of the neuropeptide α-CGRP, which is derived from the calcitonin gene. This peptide is a reduced form of human α-CGRP, featuring specific amino acid substitutions and modifications that influence its biological activity and structure. Synonyms: α-Calcitonin gene-related peptide (human reduced), 1-L-serine-3-L-asparagine-25-L-aspartic acid-35-L-glutamic acid-; Calcitonin gene related peptide rat; L-Seryl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-valyl-L-threonyl-L-histidyl-L-arginyl-L-leucyl-L-alanylglycyl-L-leucyl-L-leucyl-L-seryl-L-arginyl-L-serylglycylglycyl-L-valyl-L-valyl-L-lysyl-L-α-aspartyl-L-asparaginyl-L-phenylalanyl-L-valyl-L-prolyl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-α-glutamyl-L-alanyl-L-phenylalaninamide; H-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2. Grade: ≥95%. CAS No. 96827-03-1. Molecular formula: C162H264N50O52S2. Mole weight: 3808.31. | |
| 1-(tert-Butyloxycarbonyl)-3-Fluoro-4-aminopiperidine | 1-(tert-Butyloxycarbonyl)-3-Fluoro-4-aminopiperidine is a reactant in the preparation of pharmaceutical compounds which are antagonists of CGRP (Calcitonin gene-related peptide) receptors and useful in the treatment of migraine. Group: Biochemicals. Grades: Highly Purified. CAS No. 934536-10-4. Pack Sizes: 100mg, 500mg. Molecular Formula: C10H19FN2O2, Molecular Weight: 218.27. US Biological Life Sciences. | Worldwide |
| 2-Amino-3-chlorobenzyl Alcohol | A useful reactant in the synthesis of CGRP-receptor antagonists and PI3K inhibitors. Group: Biochemicals. Alternative Names: 2-Amino-3-chloro-benzenemethanol; 2-Chloro-5-hydroxymethylaniline. Grades: Highly Purified. CAS No. 61487-25-0. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| (2R)-2-Amino-3-(4-aminophenyl)propanoic Acid | (2R)-2-Amino-3-(4-aminophenyl)propanoic Acid is an amino acid that is used as a reactant in the development of human calcitonin gene-related peptide (CGRP) receptor antagonists for treatment of acute migraine. Group: Biochemicals. Grades: Highly Purified. CAS No. 102281-45-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H12N2O2. US Biological Life Sciences. | Worldwide |
| AC 187 | AC 187 is a potent amylin receptor antagonist (IC50 = 0.48 nM) displaying 38- and 400-fold selectivity over calcitonin and CGRP receptors respectively. It inhibits amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. It increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo. Synonyms: Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2; N-acetyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-L-asparagyl-L-threonyl-L-tyrosinamide; AC187; salmon calcitonin (8-32) reduced; acetyl-(Asn30,Tyr32)sCT(8-37); AC-187. Grade: >98%. CAS No. 151804-77-2. Molecular formula: C127H205N37O40. Mole weight: 2890.25. | |
| AC 187 | AC 187 is a potent and orally active amylin receptor antagonist with an IC 50 of 0.48 nM and a K i of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 151804-77-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1393. | |
| AC 187 acetate | AC 187 acetate is a potent amylin receptor antagonist (IC50 = 0.48 nM) displaying 38- and 400-fold selectivity over calcitonin and CGRP receptors respectively. It inhibits amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. It increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels, and increases food intake in vivo. Synonyms: Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2.CH3CO2H; N-acetyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-L-asparagyl-L-threonyl-L-tyrosinamide acetic acid. Grade: ≥95%. Molecular formula: C129H209N37O42. Mole weight: 2950.26. | |
| Acetyl-Amylin (8-37) (human) | Acetyl-Amylin (8-37) (human) is a most effective amylin antagonist, but its ability to block CGRP inhibition is limited. It completely reverses the inhibitory effect of IAPP on 14C-glycogen accumulation in vitro. Synonyms: Ac-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2; N-acetyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparagyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparagyl-L-asparagyl-L-phenylalanyl-glycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparagyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-threonyl-L-tyrosinamide. Grade: ≥95%. CAS No. 178603-79-7. Molecular formula: C140H218N42O46. Mole weight: 3225.53. | |
| Ac-Tyr-Arg-cetyl ester | Ac-Tyr-Arg-cetyl ester is an ingredient in anti-wrinkle cosmetics. It can inhibit the production of calcitonin gene-related peptide (CGRP), produce β-endorphins, and raise the threshold of skin sensitivity to heat. Synonyms: L-Arginine, N-acetyl-L-tyrosyl-, hexadecyl ester; Acetyl dipeptide-1 cetyl ester; Calmosensine; Calmosensine (cosmetic ingredient); Idealift; Acetyl tyrosylarginine cetyl ester; N-Acetyl dipeptide-1 cetyl ester. Grade: 98%. CAS No. 196604-48-5. Molecular formula: C33H57N5O5. Mole weight: 603.84. | |
| Adrenomedullin (11-50), rat | Adrenomedullin (11-50), rat is the C-terminal fragment (11-50) of the adrenomedullin in rats. Rat adrenomedullin induces selective arterial vasodilation through CGRP1 receptor. Synonyms: Ser-Thr-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Met-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Gly-Met-Ala-Pro-Arg-Asn-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 (Disulfide bridge: Cys4-Cys9). Grade: ≥95%. CAS No. 163648-32-6. Molecular formula: C194H304N58O59S4. Mole weight: 4521.17. | |
| Adrenomedullin (1-50), rat | Adrenomedullin (1-50), rat, a 50-amino acid peptide, induces selective arterial vasodilation by activation of the CGRP1 receptor. Synonyms: Tyr-Arg-Gln-Ser-Met-Asn-Gln-Gly-Ser-Arg-Ser-Thr-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Met-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Gly-Met-Ala-Pro-Arg-Asn-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 (Disulfide bridge: Cys14-Cys19). Grade: ≥95%. Molecular formula: C248H381N77O75S5. Mole weight: 5729.50. | |
| Adrenomedullin (AM) (22-52), human | Adrenomedullin (AM) (22-52), human, an adrenomedullin analogue with NH2 terminus truncation, is an adrenomedullin receptor antagonist that also antagonizes calcitonin-generating peptide (CGRP) receptors in the vascular bed of the hindlimb of cats. Synonyms: 22-52-Adrenomedullin (human); Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2; L-threonyl-L-valyl-L-glutaminyl-L-lysyl-L-leucyl-L-alanyl-L-histidyl-L-glutaminyl-L-isoleucyl-L-tyrosyl-L-glutaminyl-L-phenylalanyl-L-threonyl-L-alpha-aspartyl-L-lysyl-L-alpha-aspartyl-L-lysyl-L-alpha-aspartyl-L-asparagyl-L-valyl-L-alanyl-L-prolyl-L-arginyl-L-seryl-L-lysyl-L-isoleucyl-L-seryl-L-prolyl-L-glutaminyl-glycyl-L-tyrosinamide. Grade: ≥95%. CAS No. 159899-65-7. Molecular formula: C159H252N46O48. Mole weight: 3575.97. | |
| Adrenomedullin (AM) (22-52), human | Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat[1][2]. Uses: Scientific research. Group: Peptides. Alternative Names: 22-52-Adrenomedullin (human). CAS No. 159899-65-7. Pack Sizes: 500 ?g; 1 mg; 5 mg. Product ID: HY-P1471. | |
| Anti-Neurodegenerative Disease Compound Library | A unique collection of 1622 compounds related to neurodegenerative diseases can be used for HTS or HCS?- Targets include AchE, NMDA, CGRP, β -secretase, γ -secretase, Dopamine receptor, Adenosine receptor, 5-HT receptor, etc. ?- Some of them are FDA-approved; - Detailed compound information with structure, target, and biological activity description?- NMR and HPLC/LCMS validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2620. Categories: Anti-Neurodegenerative Disease Compounds Libraries. |  |
| Atogepant | Atogepant (MK-8031) is an orally active and selective calcitonin gene - related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-8031; AGN-241689. CAS No. 1374248-81-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109022. | |
| BMS694153 | BMS694153 is a potent and selective calcitonin gene-related peptide(CGRP) receptor antagonist. It is related with the pathogenesis of migraine. Uses: Bms694153 is related with the pathogenesis of migraine. Synonyms: BMS-694153; BMS 694153; BMS694153; (R)-N-(1-([1,4'-bipiperidin]-1'-yl)-3-(7-methyl-1H-indazol-5-yl)-1-oxopropan-2-yl)-4-(8-fluoro-2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carboxamide; (R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide; 4-(8-Fluoro-2-oxo-1,4-dihydroquinazolin-3-yl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamide. Grade: >98 %. CAS No. 1050381-35-5. Molecular formula: C35H45FN8O3. Mole weight: 644.79. | |
| (±)-Boc-α-phosphonoglycine trimethyl ester | (±)-Boc-α-phosphonoglycine trimethyl ester is used as a reagent in the chemical synthesis of compounds such as Biphenomycin B, which is a potent antibiotic against Gram-neg., and imidazoles as potent calcitonin gene-related peptide (CGRP) antagonists. Synonyms: (±)-Trimethyl-Boc-α-phosphonoglycinate; (Dimethoxyphosphinyl)[[(1,1-dimethylethoxy)carbonyl]amino]acetic Acid Methyl Ester; 2-(Dimethoxyphosphinyl)-2-[[(1,1-dimethylethoxy)carbonyl]amino]acetic Acid Methyl Ester; Methyl 2-[(tert-butoxycarbonyl)amino]-2-(dimethoxyphosphoryl)acetate; (+/-)-Boc-alpha-phosphonoglycine trimethyl ester; N-Boc-2-Phosphonoglycine trimethyl ester; methyl 2-dimethoxyphosphoryl-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate; N-BUTOXYCARBONYL TRIMETHYLPHOSPHONOGLYCINE; Boc-GlyP(O)(OMe)2OMe; Boc-alpha-phosphonoglycine Trimethyl Ester. Grade: ≥ 98% (TLC). CAS No. 89524-98-1. Molecular formula: C10H20NO7P. Mole weight: 297.24. | |
| Calcitonin gene-related peptide | Calcitonin gene-related peptide is a member of the calcitonin family of peptides consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2 (intermedin) and calcitonin - receptor - stimulating peptide. Synonyms: Calcitonin, pro-; CALCA protein, human; CALC1 protein, human; CGRP1 protein, human. CAS No. 83652-28-2. Molecular formula: C163H266N50O50S2. Mole weight: 3790.28. | |
| Calcitonin gene-related peptide 1 (16-25) | Calcitonin gene-related peptide 1 (16-25) is a peptide derived from Calcitonin gene-related peptide 1. Calcitonin gene-related peptide 1 dilates a variety of vessels including the coronary, cerebral and systemic vasculature. It also elevates platelet cAMP. Synonyms: Alpha-type CGRP (16-25). | |
| Calcitonin gene-related peptide free acid | Calcitonin gene-related peptide (CGRP) free acid is the deamidated form of α-CGRP(human) (HY-P1071). Calcitonin gene-related peptide can be used to study the effect of C-terminal amidation on CGRP [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: CGRP free acid. CAS No. 83652-28-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4058. | |
| Diphosphoryl Chloride 90% | Diphosphoryl Chloride is used in the synthesis of potent and orally bioavailable tricyclic CGRP receptor antagonists. Also used in the synthesis of transition state analogue inhbitors of inosine monophosphate. Group: Biochemicals. Alternative Names: Pyrophosphoryl Chloride; Phosphorodichloridic Anhydride; Phosphorus Chloride Oxide; Pyrophosphoryl Tetrachloride; Tetra chloropyrophosphoric Acid. Grades: Highly Purified. CAS No. 13498-14-1. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Eptinezumab | Eptinezumab is a humanized monoclonal antibody. Eptinezumab binds to calcitonin gene-related peptide (CGRP) and blocks its interaction with the receptor. Eptinezumab is used for the prevention of migraine in adults [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1644539-04-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99017. | |
| Eptinezumab | Eptinezumab is a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP). Eptinezumab has been used for the preventive treatment of migraine in adults. Synonyms: Vyepti. CAS No. 1644539-04-7. | |
| Erenumab | Erenumab is a fully human monoclonal antibody. Erenumab inhibits the calcitonin gene - related peptide ( CGRP ) receptor. Erenumab can be used for the prevention of episodic migraine [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1582205-90-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9938. | |
| Erenumab | Erenumab is a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP). Erenumab has been used for the preventive treatment of migraines. Synonyms: Aimovig. CAS No. 1582205-90-0. | |
| Fremanezumab | Fremanezumab is a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP). Fremanezumab has been investigated for the prevention of high-frequency episodic and chronic migraine. Synonyms: TEV-48125. CAS No. 1655501-53-3. | |
| Fremanezumab | Fremanezumab (TEV-48125) is a humanized IgG2a monoclonal antibody that selectively and potently binds to calcitonin gene-related peptide (CGRP). CGRP is a 37-amino acid neuropeptide involved in central and peripheral pathophysiological events of migraine. Fremanezumab has the potential for chronic migraine research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: TEV-48125. CAS No. 1655501-53-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99019. | |
| Galcanezumab | Galcanezumab is a humanized monoclonal antibody that selectively binds to calcitonin gene-related peptide (CGRP). Galcanezumab has the potential for the preventive treatment of chronic migraine. Synonyms: LY 2951742; LY2951742; LY-2951742. CAS No. 1578199-75-3. | |
| Galcanezumab | Galcanezumab (LY 2951742) is a humanized IgG4 monoclonal antibody against the CGRP ligand. Galcanezumab can be used for migraine or cluster headaches research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LY 2951742. CAS No. 1578199-75-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99021. | |
| MK-3207 | MK-3207 is an orally active, highly selective and species-specific CGRP receptor antagonist (for human CGRP receptor : IC 50 =0.12 nM; K i =0.024 nM). MK-3207 can be used for migraine studies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 957118-49-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-10301. | |
| MK-3207 Hydrochloride | MK-3207 (Hydrochloride) is a potent and orally bioavailable CGRP receptor antagonist with IC 50 of 0.12 nM and K i of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3. Uses: Scientific research. Group: Signaling pathways. CAS No. 957116-20-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-10302. | |
| Olcegepant | Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIBN-4096; BIBN 4096BS. CAS No. 204697-65-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10095. | |
| Olcegepant | Olcegepant is a potent and selective calcitonin gene-related peptide (CGRP) receptor antagonist. Olcegepant displays high affinity for human CGRP receptors and exhibits no significant affinity for 75 other receptors. Olcegepant may a be viable option for the treatment of acute migraines. Group: Biochemicals. Alternative Names: 1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)piperazine; N- [ (1R) -2- [ [ (1S) -5-Amino-1- [ [4- (4-pyridinyl) -1-piperazinyl] carbonyl] pentyl] amino] -1- [ (3, 5-dibromo-4-hydroxyphenyl) methyl] -2-oxoethyl] -4- (1, 4-dihydro-2-oxo-3 (2H) -quinazolinyl) -1-piperidinecarboxamide; BIBN 4096BS; BIBN 4096. Grades: Highly Purified. CAS No. 204697-65-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Pramlintide | Pramlintide, a synthetic version of amylin, is the first in a new class of pharmaceutical agents and exhibits high affinity for amylin, CGRP and calcitonin receptors (Ki values are 0.023, 3.8 and 5.1 nM respectively). Synonyms: AC 0137; AC 137; Symlin; Tripro-Amylin; riproamylin; Pramlintide; LS-181996; LS181996; Amylin. CAS No. 151126-32-8. Molecular formula: C171H267N51O53S2. Mole weight: 3949.42. | |
| Pyruvaldehyde (35% Aqueous) | Pyruvaldehyde is used in the synthesis and cytotoxicity evaluation of N-terminal analogues of tubulysin-U an antimitotic compound. Also used in the synthesis of imidazoles as potent calcitonin gene-related CGRP antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 78-98-8. Pack Sizes: 1g, 10g, 100g, 250g, 500g. Molecular Formula: C?H?O?, Molecular Weight: 72.06. US Biological Life Sciences. | Worldwide |
| Pyruvic aldehyde, Technical Grade, 35-45% Aqueous Solution | Pyruvaldehyde is used in the synthesis and cytotoxicity evaluation of N-terminal analogues of tubulysin-U an antimitotic compound. Also used in the synthesis of imidazoles as potent calcitonin gene-related CGRP antagonists. Group: Biochemicals. Grades: Purified. CAS No. 78-98-8. Pack Sizes: 100g, 250g, 500g, 1Kg, 2Kg. Molecular Formula: C?H?O?, Molecular Weight: 72.06. US Biological Life Sciences. | Worldwide |
| Rimegepant | Rimegepant (BMS-927711) is a highly potent, oral calcitonin gene-related peptide ( CGRP ) receptor antagonist with a K i of 0.027 nM and an IC 50 of 0.14 nM for hCGRP receptor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-927711; BHV-3000. CAS No. 1289023-67-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15498. | |
| Telcagepant | Telcagepant (MK-0974) is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with K i s of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-0974. CAS No. 781649-09-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-32709. | |
| Ubrogepant | Ubrogepant (MK-1602) is an orally active and selective antagonist of calcitonin gene-related peptide receptor ( CGRP ). Ubrogepant has high affinity for CGRP receptors in human and rhesus monkeys, and can effectively block the cAMP response stimulated by α-CGRP. Ubrogepant can be used in the study of acute migraine [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-1602. CAS No. 1374248-77-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12366. | |
| Umbellulone | Offensive principle of the so-called "headache tree". Causes a painful cold sensation. Selective TRPA1 activator. Weak TRPM8 activator. Releases CGRP (calcitoningene-related peptide) after TRPA1 activation which leads to activation of trigeminovascular pathways and CGRP-mediated neurogenic vasodilatation relevant to produce headache/migraine. Group: Biochemicals. Grades: Highly Purified. CAS No. 546-78-1. Pack Sizes: 10mg. Molecular Formula: C10H14O. US Biological Life Sciences. | Worldwide |
| Vazegepant | Vazegepant (Zavegepant) is an orally active calcitonin gene-related peptide CGRP receptor antagonist with potential for acute research in migraine, can be administered intranasally. CGRP is an important trigger in migraine pathophysiology [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Zavegepant; BHV-3500. CAS No. 1337918-83-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134992. | |
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