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| Product | Description | |
|---|---|---|
| CHAPS | CHAPS, a derivative of Cholic acid, is a zwitterionic detergent for solubilizing membrane proteins. CHAPS is used for stabilization of various protein-DNA complexes and can retain biochemical activity of proteins in solution [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 75621-03-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15435. |  |
| CHAPS | CHAPS. CAS No. 75621-03-3. Pack Sizes: Gram Quantities: 5 gm , 1 gm. Order Number: S112. |  www.prochemonline.com |
| CHAPS ( (3-[ (3-Cholamidopropyl) dimethylammonio]-1-propanesulfonate) ) | Non-denaturing zwitterionic detergent with cholic acid and sulfobetaine moieties, used to dissolve biological membranes, useful for protein extraction methods due to its ease of removal by dialysis or gel filtration. Low background UV absorption for protein detection.Designed by Good, et al., and typically referred to as Goods buffer useful in cell culture media formulations. Selection of biological buffer systems should include the following criteria: exclusion by biological membranes, low absorption between 240 and 700nm, chemically stable, and stable to temperature and concentration changes. Group: Biochemicals. Alternative Names: (3-[ (3-Cholamidopropyl) dimethylammonio]-1-propanesulfonate) ; N,N-Dimethyl-N-(3-sulfopropyl)-3-[[(3α,5 β, 7α, 12α)-3, 7, 12-trihydroxy-24-oxocholan-24-yl]amino]-1-propanaminium Inner Salt; CHAPS. Grades: Molecular Biology Grade. CAS No. 75621-03-3. Pack Sizes: 5g, 25g, 100g. Molecular Formula: C32H58N2O7S, Molecular Weight: 614.88. US Biological Life Sciences. |  Worldwide |
| CHAPS(3-((3-Cholamidopropyl)dimethylammonio)propanesulfonate) | 25g Pack Size. Group: Buffers. Formula: C32H58N2O7S. CAS No. 75621-03-3. Prepack ID 90005195-25g. Molecular Weight 614.88. See USA prepack pricing. |  |
| CHAPS(3-((3-Cholamidopropyl)dimethylammonio)propanesulfonate) | 5g Pack Size. Group: Buffers. Formula: C32H58N2O7S. CAS No. 75621-03-3. Prepack ID 90005195-5g. Molecular Weight 614.88. See USA prepack pricing. | |
| CHAPS hydrate | CHAPS hydrate, a derivative of Cholic acid, is a zwitterionic detergent for solubilizing membrane proteins. CHAPS hydrate is used for stabilization of various protein-DNA complexes and can retain biochemical activity of proteins in solution [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 331717-45-4. Pack Sizes: 500 mg; 1 g. Product ID: HY-15435A. | |
| CHAPSO | CHAPSO. CAS No. 82473-24-3. Pack Sizes: Gram Quantities: 1 gm. Order Number: S113. | www.prochemonline.com |
| CHAPSO | CHAPSO is a zwitterionic detergent that is thermally stable. CHAPSO is able to broaden the particle orientation distribution, enabling single-particle cryo-electron microscopy (cryo-EM) to produce isotropically uniform maps. CHAPSO can eliminate the directional bias of bacterial transcription complexes and help determine the structure of bacterial transcription complexes under cryo-electron microscopy [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 3-[3- (Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate. CAS No. 82473-24-3. Pack Sizes: 100 mg; 500 mg. Product ID: HY-W040201. | |
| CHAPSO | Non-denaturing zwitterionic detergent with cholic acid and sulfobetaine moieties, used to dissolve biological membranes, useful for protein extraction methods due to its ease of removal by dialysis or gel filtration. Low background UV absorption for protein detection. Group: Biochemicals. Alternative Names: (3-[ (3-Cholamidopropyl) dimethylammonio]-2-hydroxy-1-propanesulfonate) . Grades: Molecular Biology Grade. CAS No. 82473-24-3. Pack Sizes: 5g, 25g. US Biological Life Sciences. | Worldwide |
| 3-[ (3-Cholamidopropyl) dimethylammonio]-2-hydroxy-1-propanesulfonate | 3-[ (3-Cholamidopropyl) dimethylammonio]-2-hydroxy-1-propanesulfonate. Group: Biochemicals. Alternative Names: CHAPSO. Grades: Highly Purified. CAS No. 82473-24-3. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. US Biological Life Sciences. | Worldwide |
| ASB-16 (3- [N, N-Dimethyl (3-palmitoylaminopropyl) ammonio] propanesulfonate; Amidosulfobetaine-16) | A zwitterionic detergent useful for the solubilization of proteins including previously undetected membrane proteins. ASB-16 exhibits better protein solubilization properties than CHAPS. Also useful for solubilizing proteins for 2D-gel electrophoresis. Group: Biochemicals. Grades: Highly Purified. CAS No. 52562-29-5. Pack Sizes: 1g, 5g. US Biological Life Sciences. | Worldwide |
| Deoxy-bigCHAP | A non-ionic, cholamide-type detergent with properties comparable to CHAPS and CHAPSO but with reduced electrostatic interactions. Suited for ion exchange chromatography. Used for membrane solubilization. It is easily removed by dialysis and its absorption at UV region is very low. N, N-Bis[3- (D-gluconamido) propyl]deoxycholamide is used for membrane solubilization and proteomic analysis. Group: Biochemicals. Alternative Names: N,N-Bis[3-D-gluconamidopropyl]-deoxycholamide. Grades: Highly Purified. CAS No. 86303-23-3. Pack Sizes: 100mg, 500mg, 1g. Molecular Formula: C??H??N?O??, Molecular Weight: 862.06. US Biological Life Sciences. | Worldwide |
| Deoxy-Bigchap (N,N-Bis[3-D-gluconamidopropyl]-deoxycholamide. ) | A nonionic detergent with properties comparable to CHAPS and CHAPSO but with reduced electrostatic interactions. Suited for ion exchange chromatography. Group: Biochemicals. Alternative Names: N,N-Bis[3-D-gluconamidopropyl]-deoxycholamide. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Native Rat Angiotensin Converting Enzyme | Angiotensin-converting enzyme (EC 3.4.15.1), or "ACE" indirectly increases blood pressure by causing blood vessels to constrict. It does that by converting angiotensin I to angiotensin II, which constricts the vessels. For this reason, drugs known as ACE inhibitors are used to lower blood pressure. ACE, angiotensin I and angiotensin II are part of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE is secreted in the lungs and kidneys by cells in the endothelium (inner layer) of blood vessels. Applications: Positive control. Group: Enzymes. Synonyms: ACE; Angiotensin Converting Enzyme; EC 3.4.15.1; dipeptid....1 M phosphate buffer and 300 mM NaCl at pH 8.3 at 37°C. Storage: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Form: Liquid in 100 mM phosphate buffered saline, 150 mM NaCl, pH 7.4 with 0.2mM CHAPS. Source: Rat lung. Species: Rat. ACE; Angiotensin Converting Enzyme; EC 3.4.15.1; dipeptidyl carboxypeptidase I; peptidase P; dipeptide hydrolase, peptidyl dipeptidase; angiotensin converting enzyme; kininase II; angiotensin I-converting enzyme; carboxycathepsin; dipeptidyl carboxypeptidase; "hypertensin converting enzyme" peptidyl dipeptidase I; peptidyl-dipeptide hydrolase; peptidyldipeptide hydrolase; endothelial cell peptidy |  |
| RGA-C11 | It is a mild glucoside detergent that can be used as an alternative to GDN, digitalin and CHAPS. Due to the formation of small protein-detergent complexes (PDCs) with GPCRs and their enhanced stability, this detergent is conducive to the determination of protein structures, particularly for CryoEM-based structural study. Synonyms: resorcinarene-based amphiphile-C11. Grades: >99%. CAS No. 2390023-16-0. Molecular formula: C132H216O56. Mole weight: 2699.09. |  |
| 116-9e | 116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)'s endogenous ATPase activity and the TAg-mediated activation of Hsp70. Uses: Designed for use in research and industrial production. Additional or Alternative Names: UPCMLD00WMAL2-11B; HMS2227G12; UPCMLD00WMAL2-11B:004; UPCMLD00WMAL2-11B:002; UPCMLD00WMAL2-11B:003. Product Category: Inhibitors. Appearance: Solid. CAS No. 831217-43-7. Molecular formula: C31H32N2O5. Mole weight: 512.6. Purity: 0.96. IUPACName: 6-[4-methyl-2-oxo-5-phenylmethoxycarbonyl-6-(4-phenylphenyl)-1,6-dihydropyrimidin-3-yl]hexanoic acid. Canonical SMILES: CC1=C(C(NC(=O)N1CCCCCC(=O)O)C2=CC=C(C=C2)C3=CC=CC=C3)C(=O)OCC4=CC=CC=C4. Product ID: ACM831217437. Alfa Chemistry ISO 9001:2015 Certified. Categories: 1160s in England. |  |
| 17-DMAG hydrochloride | 17-DMAG hydrochloride (Alvespimycin hydrochloride) is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Synonyms: 17-DMAG HCl; Alvespimycin HCl; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin Hydrochloride; 17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride; 17-Demethoxy-17-[[2- (dimethylamino) ethyl]amino]geldanamycin Hydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride. Grades: >98%. CAS No. 467214-21-7. Molecular formula: C32H48N4O8.HCl. Mole weight: 653.21. | |
| 1-Deoxythiomannojirimycin | 1-deoxythiomannojirimycin is a formidable inhibitor of glycosidase enzymes, studied extensively for its capacity to treat a host of lysosomal storage diseases, including but not limited to Gaucher and Pompe. It assumes the role of a molecular chaperone, augmenting cellular activity linked with lysosomal enzymes that are otherwise indisposed due to disease. Synonyms: (2R,3S,4R,5S)-3,4,5-Trihydroxy-2-hydroxymethylthiane. Molecular formula: C6H12O4S. Mole weight: 180.22. | |
| 2, 4-Dimethyl Benzene sulfonyl Chloride | 2, 4-Dimethyl Benzene sulfonyl Chloride is used as a reagent in the synthesis of dimethyl benzimidazolones as potent and selective inhibitors of BRPF1 bromodomain. 2, 4-Dimethyl Benzene sulfonyl Chloride is also used as a reagent in the synthesis of quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for the treatment of Gaucher disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 609-60-9. Pack Sizes: 1g, 5g. Molecular Formula: C8H9ClO2S. US Biological Life Sciences. | Worldwide |
| 3-Aminobenzoic-d4 Acid | A chemoattractants against Pseudomonas strains. A reactant used in the preparation of influenza neuraminidase inhibitors, inhibitors of transthyretin amyloid fibril formation and Iihibitors of the protein chaperone Hsp90. Group: Biochemicals. Alternative Names: 3-Aminobenzenecarboxylic Acid; 3-Carboxyaniline; Aniline-3-carboxylic Acid; NSC 15012; m-Aminobenzoic Acid; m-Anthranilic Acid; m-Carboxyaniline; m-Carboxyphenylamine. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-Aminopropyl b-D-galactopyranoside | 3-Aminopropyl b-D-galactopyranoside is a valuable compound commonly used as a glycosylation compound and chaperone in various biochemistry studies. This compound serves as a precursor for the research and development of glycolipids and glycoproteins. Additionally, it has been employed to investigate lectin-carbohydrate interactions. Molecular formula: C9H19NO6. Mole weight: 237.25. | |
| 4-Phenylbutyric Acid | A chemical chaperone involved in protein-folding disorders. Group: Biochemicals. Alternative Names: Benzenebutanoic Acid; 4-Phenyl-n-butyric Acid; γ-Phenylbutanoic Acid; NSC 295. Grades: Highly Purified. CAS No. 1821-12-1. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 4-Phenylbutyric Acid-13C6 | Labeled 4-Phenylbutyric Acid , a chemical chaperone involved in protein-folding disorders. Group: Biochemicals. Alternative Names: Benzene-13C6-butanoic Acid; γ-Phenyl-13C6-butanoic Acid. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Afegostat | Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase ( GCase ) in the endoplasmic reticulum (ER) with high affinity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: D-Isofagomine; Isofagomine. CAS No. 169105-89-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-14829. | |
| Afegostat D-Tartrate | Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase ( GCase ) in the endoplasmic reticulum (ER) with high affinity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: D-Isofagomine D-Tartrate; Isofagomine D-Tartrate. CAS No. 957230-65-8. Pack Sizes: 1 mg. Product ID: HY-14829E. | |
| alpha-2-macroglobulin receptor-associated protein precursor (252-260) | Alpha-2-macroglobulin receptor-associated protein precursor (252-260) is a peptide corresponding to residues 252-260 of alpha-2-macroglobulin receptor-associated protein precursor. Alpha-2-MRAP is a molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. Synonyms: Alpha-2-MRAP precursor (252-260). | |
| Ambroxol | Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NA-872. CAS No. 18683-91-5. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1039. | |
| Ambroxol hydrochloride | Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NA-872 hydrochloride. CAS No. 23828-92-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1039A. | |
| Amlexanox | Antiallergic. Anti-inflammatory. Antagonizes the angiogenic and mitogenic activity of FGF-1 through S100A13. Inhibits FGF-1 release. Binds to HSP90. Inhibits C-terminal chaperone activity. Induces an increase in nonsense-containing mRNAs amount in treated cells, leading to the synthesis of functional full-length proteins in an efficient manner. Selective inhibitor of TANK-binding Kinase 1 (TBK1) and IKKepsilon. Reversibly lowers weight and improves insulin sensitivity and reduces inflammation and attenuated hepatic steatosis in obese mices without affecting food intake. Group: Biochemicals. Alternative Names: 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid; Amoxanox; AA-673; CHX-3673; Aphthasol; Elics; Solfa. Grades: Highly Purified. CAS No. 68302-57-8. Pack Sizes: 25mg, 100mg, 500mg. Molecular Formula: C16H14N2O4, Molecular Weight: 298.29. US Biological Life Sciences. | Worldwide |
| AR7 | AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 80306-38-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101106. | |
| AR-7 | AR-7, also known as Atypical retinoid 7, was developed as a highly potent and selective enhancer of the chaperone-mediated autophagy (CMA) through antagonizing RAR&alpha. AR-7 was suggested to be used at 5-20 μM final concentration in vitro and in cellular assays. Synonyms: 7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine; AR 7; AR7; Atypical retinoid 7. CAS No. 80306-38-3. Molecular formula: C15H12ClNO. Mole weight: 257.71. | |
| Arimoclomol Maleic Acid | Arimoclomol is a orally administered drug used to treat amyotrophic lateral sclerosis and was later discovered to be a potential insulin resistance treatment and diabetic complications. Arimoclomol is believed to function by stimulating a normal cellular protein repair pathway through the activation of molecular chaperones. Arimoclomol could treat a broad range of diseases. Arimoclomol activates the heat shock response. It is believed to act at Hsp70. Group: Biochemicals. Alternative Names: N-{[(2R)-2-Hydroxy-3-piperidin-1-ylpropyl]oxy}pyridine-3-carboximidoyl Chloride 1-Oxide (2Z)-2-butenedioate; BRX 220; BRX 345. Grades: Highly Purified. CAS No. 289893-26-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Astemizole | Astemizole is a potent and orally active nonsedating-type histamine H1 receptor antagonist with IC50 value of 4 nM. It competitively binds to histamine H1 receptor sites in the uterus, gastrointestinal tract, bronchial muscle and blood vessels. It suppresses the formation of edema and pruritus caused by histamine. It has antipruritic and anticholinergic effects. It is also a potent blocker of ether-a-go-go-related gene (ERG) potassium channel blocker with IC50 value of 0.9 nM. It exhibits antimalarial activity in multidrug resistant strains in vitro with IC50 value of 227-734 nM. It has the potential for combination therapy with antivancer drugs in resistant leukemia. It is considerably less potent at muscarinic acetylcholine receptors with Ki value of 2.4 μM. It may be used as a potential antineoplastic agent for decreasing proliferation of various cancer cells. It may be used as a pharmacological chaperone to restore protein function for some mutated forms of hERG channels and correct folding defects. It was developed by Johnson & Johnson. Synonyms: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzim; Laridal; 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; Astemisan; Hismanal; Histamen; Paralergin; R 42512; Retolen; Waruzol. Grades: ≥99% by HPLC. CAS No. 68844-77-9. Molecular formula: C28H31FN4O. Mole weight: 458.57. | |
| Azoramide | Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It is a dual-function endoplasmic reticulum (ER) modulator in vitro. It improves endoplasmic reticulum (ER) protein-folding ability and stimulates the expression of ER chaperones to protect cells against ER stress in multiple systems. It regulates ER folding and secretion capacity without inducing ER stress. It might have the protective effects of enhancing chaperone expression and reducing protein synthesis without inducing cytotoxicity and apoptosis. It showed potent antidiabetic activity in two independent mouse models of obesity by protecting pancreatic β cell function against ER stress and improving insulin sensitivity in vivo. It improves glucose homeostasis in mice with genetic obesity and diet-induced obesity. Synonyms: N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide. Grades: >98%. CAS No. 932986-18-0. Molecular formula: C15H17ClN2OS. Mole weight: 308.82. | |
| benzyl 3-O-benzyl-2-acetamido-2-deoxy-α-D-glucopyranoside | Benzyl 3-O-benzyl-2-acetamido-2-deoxy-α-D-glucopyranoside, a well-known chemical compound within the biomedical industry, is frequently employed in the realms of diversified research. This versatile substrate proffers great potential for investigating the essential role of β-N-acetylhexosaminidase, an enzyme chaperoning lysosomal degradation. And yet, its profound value extends further still, as it may also be utilized to synthesize glycopeptides and explore the interaction between carbohydrates and proteins. Synonyms: N-[(2S,3R,4R,5S,6R)-5-hydroxy-6-(hydroxymethyl)-2,4-bis(phenylmethoxy)oxan-3-yl]acetamide; alpha-D-Glucopyranoside, phenylmethyl 2-(acetylamino)-2-deoxy-3-O-(phenylmethyl)-; Benzyl 3-O-benzyl-2-acetamido-2-deoxy-alpha-D-glucopyranoside; SCHEMBL5841546; IYODMICTBRMKGJ-LMYCIYFBSA-N; DTXSID901143418; AKOS003631747; Phenylmethyl 2-(acetylamino)-2-deoxy-3-O-(phenylmethyl)-|A-D-Glucopyranoside; Phenylmethyl 2-(acetylamino)-2-deoxy-3-O-(phenylmethyl)--D-Glucopyranoside; Phenylmethyl 2-(acetylamino)-2-deoxy-3-O-(phenylmethyl)-alpha-D-Glucopyranoside. Grades: 98%. CAS No. 14146-27-1. Molecular formula: C22H27NO6. Mole weight: 401.45. | |
| BIX | BIX is a BiP (Hsp70-5) ER chaperone inducer that induces BiP expression in vitro and in vivo. BIX protects against ER-stress induced cell death in neuronal and retinal cell lines, and also protects against ischaemia-induced hippocampal cell death in vivo. Synonyms: 2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid; Thiocyanic acid,2-(3,4-dihydroxyphenyl)-2-oxoethyl ester. Grades: ≥98% by HPLC. CAS No. 101714-41-4. Molecular formula: C9H7NO3S. Mole weight: 209.22. | |
| Blood Group H-BSA (15 atom spacer) | Blood Group H-BSA (15 atom spacer) is an indispensable biomolecular tool that plays an important role in biomedicine by enabling improved detection and rigorous analysis of blood group antigens, which are fundamental to understanding human immune function. Utilizing this product in experimental settings provides valuable insights into the molecular recognition of H blood group antigens by chaperone and polymerase proteins, with potential applications in cancer diagnosis and treatment. | |
| CBL0137 | CBL0137, a curaxin compound, is a histone chaperone facilitates chromatin transcription (FACT) inhibitor. CBL0137 downregulates NF- B and activates p53. CBL0137 restores both histone H3 acetylation and trimethylation. CBL0137 is an anticancer agent. CBL0137 induces cancer cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Curaxin 137; CBL-C137. CAS No. 1197996-80-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935. | |
| CBL0137 | CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 μM and inhibits NF-κB with an EC50 of 0.47 μM. It also inhibits histone chaperone FACT (facilitates chromatin transcription) and MYC signal. Synonyms: CBL0137; CBL-0137; CBL 0137; CBLC137; CBLC-137; CBLC 137; Curaxin 137; 1,1'-(9-(2-(Isopropylamino)ethyl)-9H-carbazole-3,6-diyl)diethanone; 1-[6-acetyl-9-[2-(propan-2-ylamino)ethyl]carbazol-3-yl]ethanone. CAS No. 1197996-80-7. Molecular formula: C21H24N2O2. Mole weight: 336.435. | |
| CBL0137 hydrochloride | CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC 50 s of 0.37 and 0.47 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Curaxin-137 hydrochloride; CBL-C137 hydrochloride. CAS No. 1197397-89-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935A. | |
| chaperonin ATPase | Multisubunit proteins with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or entry into mitochondria and chloroplasts. Molecular masses of subunits ranges from 10-90 kDa. They are a subclass of molecular chaperones that are related to EC 3.6.4.8 (proteasome ATPase). Group: Enzymes. Synonyms: chaperonin. Enzyme Commission Number: EC 3.6.4.9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4711; chaperonin ATPase; EC 3.6.4.9; chaperonin. Cat No: EXWM-4711. | |
| Cucurbitacin D | Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis , exhibiting anti-tumor and anti-inflammatory effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 3877-86-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N1986. | |
| Cuproptosis Compound Library | 411 active small molecules associated with cuproptosis for high-throughput and high-intensity screening. - Targeting Ferredoxin 1 (FDX1), Antioxidant 1 Copper Chaperone (ATOX1), CCS (copper chaperones), mitochondrial respiration, etc. - Some compounds are FDA-approved. - Detailed instructions, compound structure, target information, description of activity, etc. - Various detection techniques such as NMR, HPLC/LCMS to ensure the correct structure and high purity of the product and reduce false positives. Uses: Scientific use. Product Category: L8710. Categories: Cuproptosis Compounds Libraries. |  |
| Curcuma Xanthorrhiza (Temulawak) Oil - CO2 | Temulawak is extracted from dried Curcuma xanthorrhiza rhizomes (roots) organically grown in Java, Indonesia. The producer advises that Javanese Turmeric Co2 is a beneficial ingredient in skin care formulations due to its ability to soothe dry, irritated or chapped skin. Skin conditions of acne, eczema, and psoriasis benefit from the soothing and antimicrobial activity of Javanese Turmeric Co2. It may also be used in oral care products because of the antimicrobial efficacy especially against streptococcus mutans. General use: Massage oil, perfume, bath and body skin care, spa treatment oils and creams, soaps, candles. Uses: Pharmaceutical. Group: Plant Extracts. INCI Names: Curcuma Xanthorrhiza Root Oil. Grades: INDUSTRIAL GRADE. CAS No. 89998-05-0. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: CU-003. Olfactive Profile: Herbaceous, spicy. EC No: 289-742-6. Origin: Indonesia. |  New Jersey |
| Derrubone | Derrubone is a prenylated isoflavone, a type of flavonoid. It was originally isolated from the Indian tree Derris robusta.It has potential application as an inhibitor of Hsp90 to its function as a chaperone protein. Synonyms: 5,7-Dihydroxy-3',4'-methylenedioxy-6-prenylisoflavone. Grades: >98%. CAS No. 22044-58-2. Molecular formula: C21H18O6. Mole weight: 366.37. | |
| DS-2248 | DS-2248 is an orally active and small molecule inhibitor of Hsp90, with potential antineoplastic activity. Upon oral administration, Hsp90 inhibitor DS-2248 specifically blocks Hsp90, which inhibits its chaperone function and promotes the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. This may result in an inhibition of tumor cell proliferation. Synonyms: DS2248; DS-2248; DS 2248. Grades: >98%. CAS No. 1696408-04-4. | |
| Ganetespib | Ganetespib, also known as STA-9090, is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor STA-9090 binds to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional Hsp90 for maintenance. Hsp90, a 90 kDa molecular chaperone upregulated in a variety of tumor cells, plays a key role in the conformational maturation, stability and function of "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used as a surrogate marker for Hsp90 inhibition. Synonyms: STA-9090; STA 9090; STA9090. Grades: >98%. CAS No. 888216-25-9. Molecular formula: C20H20N4O3. Mole weight: 364.40. | |
| Geldanamycin (Streptomyces hygroscopicus) 98+% | Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. A potent antitumor 1 and potent inhibitor of p60c-crc tyrosine kinase, erb B2,2 EGF receptor tyrosine kinase and non-receptor tyrosine kinases. 3, Geldanamycin binds specifically and inhibits the chaperone protein Hsp90.2. Group: Biochemicals. Alternative Names: 9, 13-Dihydroxy-8, 14, 19-trimethoxy-4, 10, 12, 16-tetramethyl-2-azabicyclo[16. 3. 1]docosa-4, 6, 10, 18, 21-pentaene-3, 20, 22-trione 9-Carbamate; (+)-Geldanamycin; NSC 122750; NSC 212518; BRN1633093. Grades: Highly Purified. CAS No. 30562-34-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| grixazone synthase | A type 3 multi copper protein. The enzyme, isolated from the bacterium Streptomyces griseus, catalyses an 8 electron oxidation. Activation of the enzyme requires a copper chaperone (GriE). It also acts on 3-amino-4-hydroxybenzaldehyde, giving grixazone A. The second aldehyde group is presumably lost as formate. The enzyme also catalyses the reaction of EC 1.10.3.4 o-aminophenol oxidase. Group: Enzymes. Synonyms: GriF. Enzyme Commission Number: EC 1.10.3.15. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0481; grixazone synthase; EC 1.10.3.15; GriF. Cat No: EXWM-0481. | |
| Herbimycin A (Herbimycin, Antibiotic TAN 420F) | Herbimycin A is the major analogue of a complex of benzoquinone ansamycin antibiotics isolated from a Streptomyces hygroscopicus. Herbimycin A inhibits the 90-kD heat-shock protein (Hsp90) which provides essential chaperone support to various signal transduction molecules, including including certain steroid hormone receptors and select kinases. Herbimycin has also been shown to inhibit protein tyrosine kinase and angiogensis. Group: Biochemicals. Alternative Names: Herbimycin, Antibiotic TAN 420F. Grades: Highly Purified. CAS No. 70563-58-5. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| HSP70 Activator II, YM-08 ( (2Z, 5E) -3-ethyl-5- (3-methylbenzo[d]thiazol-2 (3H) -ylidene) -2- (pyridin-2-ylmethylene) thiazolidin-4-one, Heat Shock 70kD Protein Activator II, Hsp70 Chemical Co-Chaperone II, YM-08, YM08, YM8) | A cell-permeable, neutrally charged, pyridinium-to-pyridine substituted YM-01 and MKT-077 structural analog that exhibits higher HSP70-binding affinity, but reduced tau degradation-promoting potency in cultures (% degradation of p-tau/total tau = 42/64, 88/89, and 81/80 in HeLaC3 with 30uM YM-08, MKT-077, or YM-01, respectively) and weaker anti-cancer activity (IC50 against MDA-MB-231/MCF10A/MCF7 inuM = 1.4/3.0/2,2/MKT-077, 2.0/3.3/5.2/YM-01, and 8.5/7.8/10.5/YM-08 in 72h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Hsp990 | HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (HSP90) with potential antineoplastic activity. HSP990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. HSP90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses. Synonyms: NVP-HSP990; NVP HSP990; NVPHSP990; HSP 990; HSP-990. Grades: >98%. CAS No. 934343-74-5. Molecular formula: C20H18FN5O2. Mole weight: 379.39. | |
| Icapamespib | Icapamespib, also known as PU-HZ 151, is a heat shock protein 90 (HSP90) inhibitor. PU-HZ151 showed EC50 of 5 nM in the FP assay as compared to 11 nM for PU-H71 and a logD of 2.37 as compared to 1.21 for PU-H71. PU-HZ151 and radiolabeled PU-HZ151 showed selectivity for epichaperomes over the individual chaperome members. Icapamespib demonstrated the ability to productively engage the target in cells, mice, and humans. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Icapamespib; PU-HZ 151; PU-HZ-151; PU-HZ151; PUHZ 151; PUHZ-151; PUHZ151. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1000999-96-1. Molecular formula: C19H23IN6O2S. Mole weight: 526.4. Purity: >98%. IUPACName: 9-{2-[(2,2-dimethylpropyl)amino]ethyl}-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-6-amine. Canonical SMILES: NC1=C2N=C(SC3=C(I)C=C(OCO4)C4=C3)N(CCNCC(C)(C)C)C2=NC=N1. Product ID: ACM1000999961. Alfa Chemistry ISO 9001:2015 Certified. | |
| KF-25706 | KF25706 is derivative of radicicol that binds to the Hsp90 chaperone machinery with IC50 of 39 nM. Synonyms: KF-25706; KF 25706; KF25706; 6H-Oxireno [e]? [2]?benzoxacyclotetradec?in-6, ?12 (7H) ?-dione, 8-chloro-1a,?14,?15,?15a-tetrahydro-9,?11-dihydroxy-14-methyl-, 6-oxime, (1aS,?2Z,?4E,?14R,?15aS)?-,UCS1006-S15. Grades: >98%. CAS No. 184537-25-5. Molecular formula: C18H18ClNO6. Mole weight: 379.79. | |
| KF-55823 | KF55823 is a derivative of radicicol that binds to the Hsp90 chaperone machinery. Synonyms: KF-55823; KF 55823; KF55823. Grades: >98%. CAS No. 452083-20-4. Molecular formula: C24H27ClN2O7. Mole weight: 490.94. | |
| KF-58333 | KF58333 is a novel derivative of radicicol that binds to the Hsp90 chaperone machinery, depletes p210Bcr-Abl and Raf-1 proteins followed by induction of erythroid differentiation and G1 phase accumulation, and induces apoptosis in human CML cells. Synonyms: KF-58333; KF 58333; KF58333; 6H-Oxireno [e]? [2]?benzoxacyclotetradec?in-6, ?12 (7H) ?-dione, 8-chloro-1a,?14,?15,?15a-tetrahydro-9,?11-dihydroxy-14-methyl-, 6-[O-[2-(2-oxo-1-pyrrolidinyl)?ethyl]?oxime]?, (1aR,?2Z,?4E,?6E,?14R,?15aR)?- (9CI). Grades: >98%. CAS No. 308244-21-5. Molecular formula: C24H27ClN2O7. Mole weight: 490.93. | |
| KW-2478 | KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 antagonist KW-2478 appears to inhibit Hsp90, resulting in impaired signal transduction, inhibition of cell proliferation, and the induction of apoptosis in tumor cells. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses. Synonyms: 2-(2-ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxyethyl)acetamide; KW 2478; KW2478; QY50S617NM; 2-[2-ethyl-3,5-dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl]-N,N-bis(2-methoxyethyl)acetamide; 819812-04-9 (free base); 2-[2-ethyl-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)phenyl]carbonyl-3,5-bis(oxidanyl)phenyl]-~{N},~{N}-bis(2-methoxyethyl)ethanamide. Grades: >98%. CAS No. 819812-04-9. Molecular formula: C30H42N2O9. Mole weight: 574.66. | |
| MAC13243 | MAC13243, an antibacterial agent, is a likely inhibitor of the bacterial lipoprotein targeting chaperone, LolA. Synonyms: MAC13243 HCl; MAC 13243; MAC-13243; MAC13243 hydrochloride. Grades: >98%. CAS No. 1071638-38-4. Molecular formula: C20H25Cl2N3O2S. Mole weight: 442.4. | |
| Mequinol | Mequinol (4-Methoxyphenol)yes Mercurialis One of the bioactive ingredients, mainly used for skin discoloration [1]. MequinolIs an antioxidant that has additive/synergistic effects on carcinogenesis when combined with other phenolic antioxidants. Mequinolalso promote hERαDependent chaperone production with potential estrogenic activity [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: p-Hydroxyanisole. CAS No. 150-76-5. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-30270. | |
| Midasin (1471-1481) | Midasin (1471-1481) is amino acids 1471 to 1481 fragment of Midasin. Midasin is a member of the AAA(+) family of ATPases. It is a nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Synonyms: Dynein-related AAA-ATPase MDN1 (1471-1481). Grades: >98%. | |
| Migalastat HCl | Migalastat HCl, also known as AT1001 or GR181413A, is a pharmacological chaperone that selectively binds, stabilizes, and increases cellular levels of α-Gal A. Oral administration of migalastat HCl reduces tissue GL-3 in Fabry transgenic mice, and in urine and kidneys of some FD patients. Migalastat HCl may provide a potential novel genotype-specific treatment for Fabry Disease (FD). Phase 3 studies are ongoing. Fabry disease (FD) is a genetic disorder resulting from deficiency of the lysosomal enzyme α-galactosidase A (α-Gal A) which leads to globotriaosylceramide (GL-3) accumulation in multiple tissues. Synonyms: 1,5-Dideoxy-1,5-imino-D-galactitol HCl; DGJ; (2R,3S,4R,5S)-2-methylolpiperidine-3,4,5-triol hydrochloride; Migalastat hydrochloride; Amigal. Grades: 98%. CAS No. 75172-81-5. Molecular formula: C6H13NO4.HCl. Mole weight: 199.63. | |
| Migalastat hydrochloride | Migalastat (GR181413A free base) hydrochloride is an orally active α-galactosidase A molecular chaperone, with an IC 50 value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GR181413A. CAS No. 75172-81-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-14929A. | |
| MKT 077 | MKT-077 is a cationic rhodacyanine dye. It shows antiproliferative activity against cancer cell lines with EC50s value of 1.4-2.2 μM in vitro through its ability to inhibit members of the heat shock protein 70 family of molecular chaperones. Synonyms: MKT-077; MKT 077; MKT077; FJ-776; FJ 776; FJ776; 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride. Grades: ≥98% by HPLC. CAS No. 147366-41-4. Molecular formula: C21H22ClN3OS2. Mole weight: 432. | |
| ML346 | ML346, a barbituric acid skeleton compound, is a novel activator of Hsp70 which could induce HSF-1-dependent chaperone expression and repair protein folding in both cellular and animal models. It has no obvious cytotoxicity and shows some extent of specif. Uses: Ml346 is a novel activator of hsp70 which could induce hsf-1-dependent chaperone expression and repair protein folding in both cellular and animal models. Synonyms: ML346; ML-346; ML 346; ZINC00244844; AC1LG9A8; Ambcb5772104; MLS004711999; SCHEMBL13317556. Grades: 95%. CAS No. 100872-83-1. Molecular formula: C14H12N2O4. Mole weight: 272.26. | |
| molybdenum cofactor sulfurtransferase | Contains pyridoxal phosphate. Replaces the equatorial oxo ligand of the molybdenum by sulfur via an enzyme-bound persulfide. The reaction occurs in prokaryotes and eukaryotes but MoCo sulfurtransferases are only found in eukaryotes. In prokaryotes the reaction is catalysed by two enzymes: cysteine desulfurase (EC 2.8.1.7), which is homologous to the N-terminus of eukaryotic MoCo sulfurtransferases, and a molybdo-enzyme specific chaperone which binds the MoCo and acts as an adapter protein. Group: Enzymes. Synonyms: molybdenum cofactor sulfurase; ABA3; HMCS; MoCo sulfurase; MoCo sulfurtransferase. Enzyme Commission Number: EC 2.8.1.9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3367; molybdenum cofactor sulfurtransferase; EC 2.8.1.9; molybdenum cofactor sulfurase; ABA3; HMCS; MoCo sulfurase; MoCo sulfurtransferase. Cat No: EXWM-3367. | |
| N6-(6-Amino)hexyl-ATP - 5/6-TAMRA | N6-(6-Amino)hexyl-ATP - 5/6-TAMRA, a fluorescent ATP analog, serves as an efficacious research tool for discerning ATP binding proteins viz. chaperones and transporters. Additionally, it informs studies on purinergic signaling pathways and intracellular nucleotide pools, heightening our understanding of said biological phenomena. Synonyms: N; -(6-Amino)hexyl-adenosine-5'-triphosphate, labeled with 5/6-TAMRA, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C41H49N8O17P3(free acid). Mole weight: 1018.80 (free acid). | |
| Native Bovine Ribonuclease B | Native RNase BS generated by subtilisin digestion of native RNase B comprising of amino acid residues 21-124 of RNase B, is sensitive to PNGase F digestion. Intramolecular N-glycans of bovine pancreatic RNase B function like chaperone. RNase B is found to be much faster than RNase A, while RNase A is liable to aggregate during regeneration. The stimulatory effect of Asn-oligosaccharide (which corresponds to the most predominant sugar chain of RNase B) reveals that the N-glycans of RNase B facilitates the transformation of bulky intermediates into folded, compact species. Group: Enzymes. Synonyms: Pancreatic ribonucleases; EC 3.1.27. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase; 9001-99-4. Enzyme Commission Number: EC 3.1.27.5. CAS No. 9001-99-4. Purity: > 80% (SDS-PAGE). Rnase. Activity: > 50 Kunitz units/mg protein. Storage: -20°C. Source: Bovine pancreas. Species: Bovine. Pancreatic ribonucleases; EC 3.1.27.5; RNase; RNase I; RNase B; pancreatic RNase; ribonuclease I; endoribonuclease I; ribonucleic phosphatase; alkaline ribonuclease; ribonuclease; gene S glycoproteins; Ceratitis capitata alkaline ribonuclease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-asssocd. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase; 9001-99-4. Pack: Package size based on protein content. Cat No: NATE-0656. | |
| Native Human Carbonic Anhydrase I | Carbonic anhydrase is a zinc metalloenzyme that has a molecular weight of approximately 30 kDa Da. The enzyme catalyzes the hydRation of carbon dioxide to carbonic acid. It is involved in vital processes such as pH and CO2 homeostasis, transport of bicarbonate and CO2, biosynthetic reactions, bone resorption, calcification, and tumorigenicity. Therefore, this enzyme is an important target for inhibitors with clinical applications in various pathologies such as glaucoma, epilepsy and Parkinsons disease. Applications: Carbonic anhydrase from human erythrocytes (hca) has been used to study the molten-globule state of carbonic anhydrase (ca). chaperone-like α-crystallin bi...on-small cell lung cancer. Group: Enzymes. Synonyms: Carbonic Anhydrase I; carbonate dehydRatase; carbonic anhydrase; anhydrase; carbonate anhydrase; carbonic acid anhydrase; carboxyanhydrase; carbonic anhydrase A; carbonate hydro-lyase; EC 4.2.1.1; 9001-03-0; CA-I; CA1. Enzyme Commission Number: EC 4.2.1.1. CAS No. 9001-03-0. Carbonic Anhydrase. Activity: 100-500 W-A units/mg protein. Form: powder. Source: Human erythrocytes. Species: Human. Carbonic Anhydrase I; carbonate dehydRatase; carbonic anhydrase; anhydrase; carbonate anhydrase; carbonic acid anhydrase; carboxyanhydrase; carbonic anhydrase A; carbonate hydro-lyase; EC 4.2.1.1; 9001-03-0; CA-I; CA1. Cat No: NATE-0097. | |
| Neoantimycin | A rare and unusual ring-extended member of the antimycin class; produced by a streptomyces species unrelated to antimycin-producing strains; a selective GRP78 molecular chaperone down-regulator highlights the potential of this class as research probes. Synonyms: Salicylamide, N-(15-benzyl-10-sec-butyl-14-hydroxy-3-isopropyl-7,13,13-trimethyl-2,5,9,12-tetraoxo-1,4,8,11-tetraoxacyclopentadec-6-yl)-3-formamido-. Grades: >98% by HPLC. CAS No. 22862-63-1. Molecular formula: C36H46N2O12. Mole weight: 698.75. | |
| Neoantimycin | Neoantimycin is a rare and unusual ring-extended member of the antimycin class. Neoantimycin is produced by a Streptomyces species unrelated to antimycin-producing strains. Literature references to neoantimycin are limited but the recent discovery of the closely related metabolite, prunustatin A, as a selective GRP78 molecular chaperone down-regulator highlights the potential of this class as research probes. In-house screening at Microbial Screening Technologies has shown the metabolite to possess potent nematocidal and antitumor activity with only limited antifungal activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 22862-63-1. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
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