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Product | Description | |
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CHAPS Quick inquiry Where to buy Suppliers range | CHAPS is a non-denaturing, zwitterionic detergent derived from cholic acid suitable for use as a solubilizing agent for membrane proteins. CAS No. 75621-03-3. Ebrator Biochemicals provides scientists around the global scientific community with a wide range of high purity Life Science products & Fine Chemicals. | |
CHAPS Quick inquiry Where to buy Suppliers range | CHAPS. CAS No. 75621-03-3. Pack Sizes: Gram Quantities: 5 gm , 1 gm. Order Number: S112. | www.prochemonline.com |
CHAPS ( (3-[ (3-Cholamidopropyl) dimethylammonio]-1-propanesulfonate) ) Quick inquiry Where to buy Suppliers range | Non-denaturing zwitterionic detergent with cholic acid and sulfobetaine moieties, used to dissolve biological membranes, useful for protein extraction methods due to its ease of removal by dialysis or gel filtration. Low background UV absorption for protein detection.Designed by Good, et al., and typically referred to as Goods buffer useful in cell culture media formulations. Selection of biological buffer systems should include the following criteria: exclusion by biological membranes, low absorption between 240 and 700nm, chemically stable, and stable to temperature and concentration changes. Group: Biochemicals. Alternative Names: (3-[ (3-Cholamidopropyl) dimethylammonio]-1-propanesulfonate) ; N,N-Dimethyl-N-(3-sulfopropyl)-3-[[(3α,5 β, 7α, 12α)-3, 7, 12-trihydroxy-24-oxocholan-24-yl]amino]-1-propanaminium Inner Salt; CHAPS. Grades: Molecular Biology Grade. CAS No. 75621-03-3. Pack Sizes: 5g, 25g, 100g. Molecular Formula: C32H58N2O7S, Molecular Weight: 614.88. US Biological Life Sciences. | Worldwide |
CHAPS(3-((3-Cholamidopropyl)dimethylammonio)propanesulfonate) Quick inquiry Where to buy Suppliers range | 5g Pack Size. Group: Buffers. Formula: C32H58N2O7S. CAS No. 75621-03-3. Prepack ID 90005195-5g. Molecular Weight 614.88. See USA prepack pricing. | |
CHAPS(3-((3-Cholamidopropyl)dimethylammonio)propanesulfonate) Quick inquiry Where to buy Suppliers range | 25g Pack Size. Group: Buffers. Formula: C32H58N2O7S. CAS No. 75621-03-3. Prepack ID 90005195-25g. Molecular Weight 614.88. See USA prepack pricing. | |
17-DMAG hydrochloride Quick inquiry Where to buy Suppliers range | 17-DMAG hydrochloride (Alvespimycin hydrochloride) is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Synonyms: 17-DMAG HCl; Alvespimycin HCl; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin Hydrochloride; 17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride; 17-Demethoxy-17-[[2- (dimethylamino) ethyl]amino]geldanamycin Hydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride. Grades: >98%. CAS No. 467214-21-7. Molecular formula: C32H48N4O8.HCl. Mole weight: 653.21. | |
1-Deoxythiomannojirimycin Quick inquiry Where to buy Suppliers range | 1-deoxythiomannojirimycin is a formidable inhibitor of glycosidase enzymes, studied extensively for its capacity to treat a host of lysosomal storage diseases, including but not limited to Gaucher and Pompe. It assumes the role of a molecular chaperone, augmenting cellular activity linked with lysosomal enzymes that are otherwise indisposed due to disease. Synonyms: (2R,3S,4R,5S)-3,4,5-Trihydroxy-2-hydroxymethylthiane. Molecular formula: C6H12O4S. Mole weight: 180.22. | |
2, 4-Dimethyl Benzene sulfonyl Chloride Quick inquiry Where to buy Suppliers range | 2, 4-Dimethyl Benzene sulfonyl Chloride is used as a reagent in the synthesis of dimethyl benzimidazolones as potent and selective inhibitors of BRPF1 bromodomain. 2, 4-Dimethyl Benzene sulfonyl Chloride is also used as a reagent in the synthesis of quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for the treatment of Gaucher disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 609-60-9. Pack Sizes: 1g, 5g. Molecular Formula: C8H9ClO2S. US Biological Life Sciences. | Worldwide |
3-[ (3-Cholamidopropyl) dimethylammonio]-2-hydroxy-1-propanesulfonate Quick inquiry Where to buy Suppliers range | 3-[ (3-Cholamidopropyl) dimethylammonio]-2-hydroxy-1-propanesulfonate. Group: Biochemicals. Alternative Names: CHAPSO. Grades: Highly Purified. CAS No. 82473-24-3. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. US Biological Life Sciences. | Worldwide |
3-Aminobenzoic-d4 Acid Quick inquiry Where to buy Suppliers range | A chemoattractants against Pseudomonas strains. A reactant used in the preparation of influenza neuraminidase inhibitors, inhibitors of transthyretin amyloid fibril formation and Iihibitors of the protein chaperone Hsp90. Group: Biochemicals. Alternative Names: 3-Aminobenzenecarboxylic Acid; 3-Carboxyaniline; Aniline-3-carboxylic Acid; NSC 15012; m-Aminobenzoic Acid; m-Anthranilic Acid; m-Carboxyaniline; m-Carboxyphenylamine. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
3-Aminopropyl b-D-galactopyranoside Quick inquiry Where to buy Suppliers range | 3-Aminopropyl b-D-galactopyranoside is a valuable compound commonly used as a glycosylation compound and chaperone in various biochemistry studies. This compound serves as a precursor for the research and development of glycolipids and glycoproteins. Additionally, it has been employed to investigate lectin-carbohydrate interactions. Molecular formula: C9H19NO6. Mole weight: 237.25. | |
4-Phenylbutyric Acid Quick inquiry Where to buy Suppliers range | A chemical chaperone involved in protein-folding disorders. Group: Biochemicals. Alternative Names: Benzenebutanoic Acid; 4-Phenyl-n-butyric Acid; γ-Phenylbutanoic Acid; NSC 295. Grades: Highly Purified. CAS No. 1821-12-1. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
4-Phenylbutyric Acid-13C6 Quick inquiry Where to buy Suppliers range | Labeled 4-Phenylbutyric Acid , a chemical chaperone involved in protein-folding disorders. Group: Biochemicals. Alternative Names: Benzene-13C6-butanoic Acid; γ-Phenyl-13C6-butanoic Acid. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
alpha-2-macroglobulin receptor-associated protein precursor (252-260) Quick inquiry Where to buy Suppliers range | Alpha-2-macroglobulin receptor-associated protein precursor (252-260) is a peptide corresponding to residues 252-260 of alpha-2-macroglobulin receptor-associated protein precursor. Alpha-2-MRAP is a molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. Synonyms: Alpha-2-MRAP precursor (252-260). | |
Amlexanox Quick inquiry Where to buy Suppliers range | Antiallergic. Anti-inflammatory. Antagonizes the angiogenic and mitogenic activity of FGF-1 through S100A13. Inhibits FGF-1 release. Binds to HSP90. Inhibits C-terminal chaperone activity. Induces an increase in nonsense-containing mRNAs amount in treated cells, leading to the synthesis of functional full-length proteins in an efficient manner. Selective inhibitor of TANK-binding Kinase 1 (TBK1) and IKKepsilon. Reversibly lowers weight and improves insulin sensitivity and reduces inflammation and attenuated hepatic steatosis in obese mices without affecting food intake. Group: Biochemicals. Alternative Names: 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid; Amoxanox; AA-673; CHX-3673; Aphthasol; Elics; Solfa. Grades: Highly Purified. CAS No. 68302-57-8. Pack Sizes: 25mg, 100mg, 500mg. Molecular Formula: C16H14N2O4, Molecular Weight: 298.29. US Biological Life Sciences. | Worldwide |
AR-7 Quick inquiry Where to buy Suppliers range | AR-7, also known as Atypical retinoid 7, was developed as a highly potent and selective enhancer of the chaperone-mediated autophagy (CMA) through antagonizing RAR&alpha. AR-7 was suggested to be used at 5-20 μM final concentration in vitro and in cellular assays. Synonyms: 7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine; AR 7; AR7; Atypical retinoid 7. CAS No. 80306-38-3. Molecular formula: C15H12ClNO. Mole weight: 257.71. | |
Arimoclomol Maleic Acid Quick inquiry Where to buy Suppliers range | Arimoclomol is a orally administered drug used to treat amyotrophic lateral sclerosis and was later discovered to be a potential insulin resistance treatment and diabetic complications. Arimoclomol is believed to function by stimulating a normal cellular protein repair pathway through the activation of molecular chaperones. Arimoclomol could treat a broad range of diseases. Arimoclomol activates the heat shock response. It is believed to act at Hsp70. Group: Biochemicals. Alternative Names: N-{[(2R)-2-Hydroxy-3-piperidin-1-ylpropyl]oxy}pyridine-3-carboximidoyl Chloride 1-Oxide (2Z)-2-butenedioate; BRX 220; BRX 345. Grades: Highly Purified. CAS No. 289893-26-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
ASB-16 (3- [N, N-Dimethyl (3-palmitoylaminopropyl) ammonio] propanesulfonate; Amidosulfobetaine-16) Quick inquiry Where to buy Suppliers range | A zwitterionic detergent useful for the solubilization of proteins including previously undetected membrane proteins. ASB-16 exhibits better protein solubilization properties than CHAPS. Also useful for solubilizing proteins for 2D-gel electrophoresis. Group: Biochemicals. Grades: Highly Purified. CAS No. 52562-29-5. Pack Sizes: 1g, 5g. US Biological Life Sciences. | Worldwide |
Astemizole Quick inquiry Where to buy Suppliers range | Astemizole is a potent and orally active nonsedating-type histamine H1 receptor antagonist with IC50 value of 4 nM. It competitively binds to histamine H1 receptor sites in the uterus, gastrointestinal tract, bronchial muscle and blood vessels. It suppresses the formation of edema and pruritus caused by histamine. It has antipruritic and anticholinergic effects. It is also a potent blocker of ether-a-go-go-related gene (ERG) potassium channel blocker with IC50 value of 0.9 nM. It exhibits antimalarial activity in multidrug resistant strains in vitro with IC50 value of 227-734 nM. It has the potential for combination therapy with antivancer drugs in resistant leukemia. It is considerably less potent at muscarinic acetylcholine receptors with Ki value of 2.4 μM. It may be used as a potential antineoplastic agent for decreasing proliferation of various cancer cells. It may be used as a pharmacological chaperone to restore protein function for some mutated forms of hERG channels and correct folding defects. It was developed by Johnson & Johnson. Synonyms: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzim; Laridal; 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; Astemisan; Hismanal; Histamen; Paralergin; R 42512; Retolen; Waruzol. Grades: ≥99% by HPLC. CAS No. 68844-77-9. Molecular formula: C28H31FN4O. Mole weight: 458.57. | |
Azoramide Quick inquiry Where to buy Suppliers range | Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It is a dual-function endoplasmic reticulum (ER) modulator in vitro. It improves endoplasmic reticulum (ER) protein-folding ability and stimulates the expression of ER chaperones to protect cells against ER stress in multiple systems. It regulates ER folding and secretion capacity without inducing ER stress. It might have the protective effects of enhancing chaperone expression and reducing protein synthesis without inducing cytotoxicity and apoptosis. It showed potent antidiabetic activity in two independent mouse models of obesity by protecting pancreatic β cell function against ER stress and improving insulin sensitivity in vivo. It improves glucose homeostasis in mice with genetic obesity and diet-induced obesity. Synonyms: N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide. Grades: >98%. CAS No. 932986-18-0. Molecular formula: C15H17ClN2OS. Mole weight: 308.82. | |
benzyl 3-O-benzyl-2-acetamido-2-deoxy-α-D-glucopyranoside Quick inquiry Where to buy Suppliers range | Benzyl 3-O-benzyl-2-acetamido-2-deoxy-α-D-glucopyranoside, a well-known chemical compound within the biomedical industry, is frequently employed in the realms of diversified research. This versatile substrate proffers great potential for investigating the essential role of β-N-acetylhexosaminidase, an enzyme chaperoning lysosomal degradation. And yet, its profound value extends further still, as it may also be utilized to synthesize glycopeptides and explore the interaction between carbohydrates and proteins. Synonyms: N-[(2S,3R,4R,5S,6R)-5-hydroxy-6-(hydroxymethyl)-2,4-bis(phenylmethoxy)oxan-3-yl]acetamide; alpha-D-Glucopyranoside, phenylmethyl 2-(acetylamino)-2-deoxy-3-O-(phenylmethyl)-; Benzyl 3-O-benzyl-2-acetamido-2-deoxy-alpha-D-glucopyranoside; SCHEMBL5841546; IYODMICTBRMKGJ-LMYCIYFBSA-N; DTXSID901143418; AKOS003631747; Phenylmethyl 2-(acetylamino)-2-deoxy-3-O-(phenylmethyl)-|A-D-Glucopyranoside; Phenylmethyl 2-(acetylamino)-2-deoxy-3-O-(phenylmethyl)--D-Glucopyranoside; Phenylmethyl 2-(acetylamino)-2-deoxy-3-O-(phenylmethyl)-alpha-D-Glucopyranoside. Grades: 98%. CAS No. 14146-27-1. Molecular formula: C22H27NO6. Mole weight: 401.45. | |
BIX Quick inquiry Where to buy Suppliers range | BIX is a BiP (Hsp70-5) ER chaperone inducer that induces BiP expression in vitro and in vivo. BIX protects against ER-stress induced cell death in neuronal and retinal cell lines, and also protects against ischaemia-induced hippocampal cell death in vivo. Synonyms: 2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid; Thiocyanic acid,2-(3,4-dihydroxyphenyl)-2-oxoethyl ester. Grades: ≥98% by HPLC. CAS No. 101714-41-4. Molecular formula: C9H7NO3S. Mole weight: 209.22. | |
Blood Group H-BSA (15 atom spacer) Quick inquiry Where to buy Suppliers range | Blood Group H-BSA (15 atom spacer) is an indispensable biomolecular tool that plays an important role in biomedicine by enabling improved detection and rigorous analysis of blood group antigens, which are fundamental to understanding human immune function. Utilizing this product in experimental settings provides valuable insights into the molecular recognition of H blood group antigens by chaperone and polymerase proteins, with potential applications in cancer diagnosis and treatment. | |
CBL0137 Quick inquiry Where to buy Suppliers range | CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 μM and inhibits NF-κB with an EC50 of 0.47 μM. It also inhibits histone chaperone FACT (facilitates chromatin transcription) and MYC signal. Synonyms: CBL0137; CBL-0137; CBL 0137; CBLC137; CBLC-137; CBLC 137; Curaxin 137; 1,1'-(9-(2-(Isopropylamino)ethyl)-9H-carbazole-3,6-diyl)diethanone; 1-[6-acetyl-9-[2-(propan-2-ylamino)ethyl]carbazol-3-yl]ethanone. CAS No. 1197996-80-7. Molecular formula: C21H24N2O2. Mole weight: 336.435. | |
CHAPSO Quick inquiry Where to buy Suppliers range | CHAPSO. CAS No. 82473-24-3. Pack Sizes: Gram Quantities: 1 gm. Order Number: S113. | www.prochemonline.com |
CHAPSO Quick inquiry Where to buy Suppliers range | Non-denaturing zwitterionic detergent with cholic acid and sulfobetaine moieties, used to dissolve biological membranes, useful for protein extraction methods due to its ease of removal by dialysis or gel filtration. Low background UV absorption for protein detection. Group: Biochemicals. Alternative Names: (3-[ (3-Cholamidopropyl) dimethylammonio]-2-hydroxy-1-propanesulfonate) . Grades: Molecular Biology Grade. CAS No. 82473-24-3. Pack Sizes: 5g, 25g. US Biological Life Sciences. | Worldwide |
Cucurbitacin D Quick inquiry Where to buy Suppliers range | Cucurbitacin D is an active component in Trichosanthes kirilowii, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity. Group: Biobased Products. Alternative Names: (10α,23E)-2β,16α,20,25-Tetrahydroxy-9β-methyl-19-norlanosta-5,23-diene-3,11,22-trione. Grades: 98%. CAS No. 3877-86-9. Product ID: BBC3877869. Molecular formula: C30H44O7. Mole weight: 516.67. IUPAC Name: (2S,8S,9R,10R,13R,14S,16R,17R)-17-[(E,2R)-2,6-dihydroxy-6-methyl-3-oxohept-4-en-2-yl]-2,16-dihydroxy-4,4,9,13,14-pentamethyl-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthrene-3,11-dione. Appearance: Powder. Density: 1.08 g/ml. SMILES: C[C@@]12C[C@H] ([C@@H] ([C@]1 (CC (=O)[C@@]3 ([C@H]2CC=C4[C@H]3C[C@@H] (C (=O)C4 (C)C)O)C)C)[C@] (C) (C (=O)/C=C/C (C) (C)O)O)O. | |
Cuproptosis Compound Library Quick inquiry Where to buy Suppliers range | 411 active small molecules associated with cuproptosis for high-throughput and high-intensity screening. - Targeting Ferredoxin 1 (FDX1), Antioxidant 1 Copper Chaperone (ATOX1), CCS (copper chaperones), mitochondrial respiration, etc. - Some compounds are FDA-approved. - Detailed instructions, compound structure, target information, description of activity, etc. - Various detection techniques such as NMR, HPLC/LCMS to ensure the correct structure and high purity of the product and reduce false positives. Uses: Scientific use. Product Category: L8710. Categories: Cuproptosis Compounds Libraries. | |
Curcuma Xanthorrhiza (Temulawak) Oil - CO2 Quick inquiry Where to buy Suppliers range | Temulawak is extracted from dried Curcuma xanthorrhiza rhizomes (roots) organically grown in Java, Indonesia. The producer advises that Javanese Turmeric Co2 is a beneficial ingredient in skin care formulations due to its ability to soothe dry, irritated or chapped skin. Skin conditions of acne, eczema, and psoriasis benefit from the soothing and antimicrobial activity of Javanese Turmeric Co2. It may also be used in oral care products because of the antimicrobial efficacy especially against streptococcus mutans. General use: Massage oil, perfume, bath and body skin care, spa treatment oils and creams, soaps, candles. Uses: Pharmaceutical. Group: Plant Extracts. INCI Names: Curcuma Xanthorrhiza Root Oil. Grades: INDUSTRIAL GRADE. CAS No. 89998-05-0. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: CU-003. Olfactive Profile: Herbaceous, spicy. EC No: 289-742-6. Origin: Indonesia. | New Jersey |
Curcuma Xanthorrhiza (Temulawak) Oil - CO2 Quick inquiry Where to buy Suppliers range | Temulawak is extracted from dried Curcuma xanthorrhiza rhizomes (roots) organically grown in Java, Indonesia. The producer advises that Javanese Turmeric Co2 is a beneficial ingredient in skin care formulations due to its ability to soothe dry, irritated or chapped skin. Skin conditions of acne, eczema, and psoriasis benefit from the soothing and antimicrobial activity of Javanese Turmeric Co2. It may also be used in oral care products because of the antimicrobial efficacy especially against streptococcus mutans. General use: Massage oil, perfume, bath and body skin care, spa treatment oils and creams, soaps, candles. Uses: Pharmaceutical. Group: Plant Extracts. INCI Names: Curcuma Xanthorrhiza Root Oil. Grades: INDUSTRIAL GRADE. CAS No. 89998-05-0. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: CU-003. Olfactive Profile: Herbaceous, spicy. EC No: 289-742-6. Origin: Indonesia. | New Jersey |
Deoxy-bigCHAP Quick inquiry Where to buy Suppliers range | A non-ionic, cholamide-type detergent with properties comparable to CHAPS and CHAPSO but with reduced electrostatic interactions. Suited for ion exchange chromatography. Used for membrane solubilization. It is easily removed by dialysis and its absorption at UV region is very low. N, N-Bis[3- (D-gluconamido) propyl]deoxycholamide is used for membrane solubilization and proteomic analysis. Group: Biochemicals. Alternative Names: N,N-Bis[3-D-gluconamidopropyl]-deoxycholamide. Grades: Highly Purified. CAS No. 86303-23-3. Pack Sizes: 100mg, 500mg, 1g. Molecular Formula: C??H??N?O??, Molecular Weight: 862.06. US Biological Life Sciences. | Worldwide |
Deoxy-Bigchap (N,N-Bis[3-D-gluconamidopropyl]-deoxycholamide. ) Quick inquiry Where to buy Suppliers range | A nonionic detergent with properties comparable to CHAPS and CHAPSO but with reduced electrostatic interactions. Suited for ion exchange chromatography. Group: Biochemicals. Alternative Names: N,N-Bis[3-D-gluconamidopropyl]-deoxycholamide. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
Derrubone Quick inquiry Where to buy Suppliers range | Derrubone is a prenylated isoflavone, a type of flavonoid. It was originally isolated from the Indian tree Derris robusta.It has potential application as an inhibitor of Hsp90 to its function as a chaperone protein. Synonyms: 5,7-Dihydroxy-3',4'-methylenedioxy-6-prenylisoflavone. Grades: >98%. CAS No. 22044-58-2. Molecular formula: C21H18O6. Mole weight: 366.37. | |
DS-2248 Quick inquiry Where to buy Suppliers range | DS-2248 is an orally active and small molecule inhibitor of Hsp90, with potential antineoplastic activity. Upon oral administration, Hsp90 inhibitor DS-2248 specifically blocks Hsp90, which inhibits its chaperone function and promotes the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. This may result in an inhibition of tumor cell proliferation. Synonyms: DS2248; DS-2248; DS 2248. Grades: >98%. CAS No. 1696408-04-4. | |
Ganetespib Quick inquiry Where to buy Suppliers range | Ganetespib, also known as STA-9090, is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor STA-9090 binds to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional Hsp90 for maintenance. Hsp90, a 90 kDa molecular chaperone upregulated in a variety of tumor cells, plays a key role in the conformational maturation, stability and function of "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used as a surrogate marker for Hsp90 inhibition. Synonyms: STA-9090; STA 9090; STA9090. Grades: >98%. CAS No. 888216-25-9. Molecular formula: C20H20N4O3. Mole weight: 364.40. | |
Geldanamycin (Streptomyces hygroscopicus) 98+% Quick inquiry Where to buy Suppliers range | Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. A potent antitumor 1 and potent inhibitor of p60c-crc tyrosine kinase, erb B2,2 EGF receptor tyrosine kinase and non-receptor tyrosine kinases. 3, Geldanamycin binds specifically and inhibits the chaperone protein Hsp90.2. Group: Biochemicals. Alternative Names: 9, 13-Dihydroxy-8, 14, 19-trimethoxy-4, 10, 12, 16-tetramethyl-2-azabicyclo[16. 3. 1]docosa-4, 6, 10, 18, 21-pentaene-3, 20, 22-trione 9-Carbamate; (+)-Geldanamycin; NSC 122750; NSC 212518; BRN1633093. Grades: Highly Purified. CAS No. 30562-34-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Herbimycin A (Herbimycin, Antibiotic TAN 420F) Quick inquiry Where to buy Suppliers range | Herbimycin A is the major analogue of a complex of benzoquinone ansamycin antibiotics isolated from a Streptomyces hygroscopicus. Herbimycin A inhibits the 90-kD heat-shock protein (Hsp90) which provides essential chaperone support to various signal transduction molecules, including including certain steroid hormone receptors and select kinases. Herbimycin has also been shown to inhibit protein tyrosine kinase and angiogensis. Group: Biochemicals. Alternative Names: Herbimycin, Antibiotic TAN 420F. Grades: Highly Purified. CAS No. 70563-58-5. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
HSP70 Activator II, YM-08 ( (2Z, 5E) -3-ethyl-5- (3-methylbenzo[d]thiazol-2 (3H) -ylidene) -2- (pyridin-2-ylmethylene) thiazolidin-4-one, Heat Shock 70kD Protein Activator II, Hsp70 Chemical Co-Chaperone II, YM-08, YM08, YM8) Quick inquiry Where to buy Suppliers range | A cell-permeable, neutrally charged, pyridinium-to-pyridine substituted YM-01 and MKT-077 structural analog that exhibits higher HSP70-binding affinity, but reduced tau degradation-promoting potency in cultures (% degradation of p-tau/total tau = 42/64, 88/89, and 81/80 in HeLaC3 with 30uM YM-08, MKT-077, or YM-01, respectively) and weaker anti-cancer activity (IC50 against MDA-MB-231/MCF10A/MCF7 inuM = 1.4/3.0/2,2/MKT-077, 2.0/3.3/5.2/YM-01, and 8.5/7.8/10.5/YM-08 in 72h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Hsp990 Quick inquiry Where to buy Suppliers range | HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (HSP90) with potential antineoplastic activity. HSP990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. HSP90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses. Synonyms: NVP-HSP990; NVP HSP990; NVPHSP990; HSP 990; HSP-990. Grades: >98%. CAS No. 934343-74-5. Molecular formula: C20H18FN5O2. Mole weight: 379.39. | |
KF-25706 Quick inquiry Where to buy Suppliers range | KF25706 is derivative of radicicol that binds to the Hsp90 chaperone machinery with IC50 of 39 nM. Synonyms: KF-25706; KF 25706; KF25706; 6H-Oxireno [e]? [2]?benzoxacyclotetradec?in-6, ?12 (7H) ?-dione, 8-chloro-1a,?14,?15,?15a-tetrahydro-9,?11-dihydroxy-14-methyl-, 6-oxime, (1aS,?2Z,?4E,?14R,?15aS)?-,UCS1006-S15. Grades: >98%. CAS No. 184537-25-5. Molecular formula: C18H18ClNO6. Mole weight: 379.79. | |
KF-55823 Quick inquiry Where to buy Suppliers range | KF55823 is a derivative of radicicol that binds to the Hsp90 chaperone machinery. Synonyms: KF-55823; KF 55823; KF55823. Grades: >98%. CAS No. 452083-20-4. Molecular formula: C24H27ClN2O7. Mole weight: 490.94. | |
KF-58333 Quick inquiry Where to buy Suppliers range | KF58333 is a novel derivative of radicicol that binds to the Hsp90 chaperone machinery, depletes p210Bcr-Abl and Raf-1 proteins followed by induction of erythroid differentiation and G1 phase accumulation, and induces apoptosis in human CML cells. Synonyms: KF-58333; KF 58333; KF58333; 6H-Oxireno [e]? [2]?benzoxacyclotetradec?in-6, ?12 (7H) ?-dione, 8-chloro-1a,?14,?15,?15a-tetrahydro-9,?11-dihydroxy-14-methyl-, 6-[O-[2-(2-oxo-1-pyrrolidinyl)?ethyl]?oxime]?, (1aR,?2Z,?4E,?6E,?14R,?15aR)?- (9CI). Grades: >98%. CAS No. 308244-21-5. Molecular formula: C24H27ClN2O7. Mole weight: 490.93. | |
KW-2478 Quick inquiry Where to buy Suppliers range | KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 antagonist KW-2478 appears to inhibit Hsp90, resulting in impaired signal transduction, inhibition of cell proliferation, and the induction of apoptosis in tumor cells. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses. Synonyms: 2-(2-ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxyethyl)acetamide; KW 2478; KW2478; QY50S617NM; 2-[2-ethyl-3,5-dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl]-N,N-bis(2-methoxyethyl)acetamide; 819812-04-9 (free base); 2-[2-ethyl-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)phenyl]carbonyl-3,5-bis(oxidanyl)phenyl]-~{N},~{N}-bis(2-methoxyethyl)ethanamide. Grades: >98%. CAS No. 819812-04-9. Molecular formula: C30H42N2O9. Mole weight: 574.66. | |
Lanolin Quick inquiry Where to buy Suppliers range | Lanolin is a natural wax-like substance that is derived from sheep's wool. It is also called wool wax or wool grease. Lanolin is a mixture of cholesterol, esters, and fatty acids that is used in various cosmetic and medicinal products due to its emollient and moisturizing properties. Lanolin is commonly used in skin care products, such as lotions and creams, because of its ability to hydrate and protect the skin. It is also used in hair care products, such as shampoos and conditioners, to help smooth and soften the hair. Uses: 1. Skin Care: Lanolin is commonly used in skin care products such as lotions, creams, and lip balms due to its moisturizing properties. It helps to hydrate the skin and prevent dryness and chapping. 2. Medical: Lanolin is used in medical ointments and creams due to its ability to help heal and soothe irritated skin. It is also used in wound dressings and as a lubricant during medical procedures. 3. Cosmetics: Lanolin is used in cosmetics such as makeup, hair care products, and nail polish to enhance their texture and moisturizing properties. 4. Industrial: Lanolin is used as a lubricant and rust inhibitor in various industrial applications such as machinery and metalworking. 5. Textiles: Lanolin is used in the textile industry to help waterproof and protect fabrics such as wool and leather. 6. Baby products: Lanolin is used in baby products such as diaper creams and lotions due to its natural and safe properties. Group: Emollients/Oils/Wax. Alternative Names: Lanolins;Anhydrous Lanum;Lanolin TR;Laniol;Lanox FPK 108. CAS No. 8006-54-0. Product ID: ACM8006540. IUPAC Name: Octadecyl hexadecanoate. Appearance: soft, greasy, yellow substance. Density: 0.932-0.945g/ml. SMILES: CCCCCCCCCCCCCCCCCCOC (=O)CCCCCCCCCCCCCCC. | |
MAC13243 Quick inquiry Where to buy Suppliers range | MAC13243, an antibacterial agent, is a likely inhibitor of the bacterial lipoprotein targeting chaperone, LolA. Synonyms: MAC13243 HCl; MAC 13243; MAC-13243; MAC13243 hydrochloride. Grades: >98%. CAS No. 1071638-38-4. Molecular formula: C20H25Cl2N3O2S. Mole weight: 442.4. | |
Midasin (1471-1481) Quick inquiry Where to buy Suppliers range | Midasin (1471-1481) is amino acids 1471 to 1481 fragment of Midasin. Midasin is a member of the AAA(+) family of ATPases. It is a nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Synonyms: Dynein-related AAA-ATPase MDN1 (1471-1481). Grades: >98%. | |
Migalastat HCl Quick inquiry Where to buy Suppliers range | Migalastat HCl, also known as AT1001 or GR181413A, is a pharmacological chaperone that selectively binds, stabilizes, and increases cellular levels of α-Gal A. Oral administration of migalastat HCl reduces tissue GL-3 in Fabry transgenic mice, and in urine and kidneys of some FD patients. Migalastat HCl may provide a potential novel genotype-specific treatment for Fabry Disease (FD). Phase 3 studies are ongoing. Fabry disease (FD) is a genetic disorder resulting from deficiency of the lysosomal enzyme α-galactosidase A (α-Gal A) which leads to globotriaosylceramide (GL-3) accumulation in multiple tissues. Synonyms: 1,5-Dideoxy-1,5-imino-D-galactitol HCl; DGJ; (2R,3S,4R,5S)-2-methylolpiperidine-3,4,5-triol hydrochloride; Migalastat hydrochloride; Amigal. Grades: 98%. CAS No. 75172-81-5. Molecular formula: C6H13NO4.HCl. Mole weight: 199.63. | |
MKT 077 Quick inquiry Where to buy Suppliers range | MKT-077 is a cationic rhodacyanine dye. It shows antiproliferative activity against cancer cell lines with EC50s value of 1.4-2.2 μM in vitro through its ability to inhibit members of the heat shock protein 70 family of molecular chaperones. Synonyms: MKT-077; MKT 077; MKT077; FJ-776; FJ 776; FJ776; 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride. Grades: ≥98% by HPLC. CAS No. 147366-41-4. Molecular formula: C21H22ClN3OS2. Mole weight: 432. | |
ML346 Quick inquiry Where to buy Suppliers range | ML346, a barbituric acid skeleton compound, is a novel activator of Hsp70 which could induce HSF-1-dependent chaperone expression and repair protein folding in both cellular and animal models. It has no obvious cytotoxicity and shows some extent of specif. Uses: Ml346 is a novel activator of hsp70 which could induce hsf-1-dependent chaperone expression and repair protein folding in both cellular and animal models. Synonyms: ML346; ML-346; ML 346; ZINC00244844; AC1LG9A8; Ambcb5772104; MLS004711999; SCHEMBL13317556. Grades: 95%. CAS No. 100872-83-1. Molecular formula: C14H12N2O4. Mole weight: 272.26. | |
N6-(6-Amino)hexyl-ATP - 5/6-TAMRA Quick inquiry Where to buy Suppliers range | N6-(6-Amino)hexyl-ATP - 5/6-TAMRA, a fluorescent ATP analog, serves as an efficacious research tool for discerning ATP binding proteins viz. chaperones and transporters. Additionally, it informs studies on purinergic signaling pathways and intracellular nucleotide pools, heightening our understanding of said biological phenomena. Synonyms: N; -(6-Amino)hexyl-adenosine-5'-triphosphate, labeled with 5/6-TAMRA, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C41H49N8O17P3(free acid). Mole weight: 1018.80 (free acid). | |
Neoantimycin Quick inquiry Where to buy Suppliers range | Neoantimycin is a rare and unusual ring-extended member of the antimycin class. Neoantimycin is produced by a Streptomyces species unrelated to antimycin-producing strains. Literature references to neoantimycin are limited but the recent discovery of the closely related metabolite, prunustatin A, as a selective GRP78 molecular chaperone down-regulator highlights the potential of this class as research probes. In-house screening at Microbial Screening Technologies has shown the metabolite to possess potent nematocidal and antitumor activity with only limited antifungal activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 22862-63-1. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
Neoantimycin Quick inquiry Where to buy Suppliers range | A rare and unusual ring-extended member of the antimycin class; produced by a streptomyces species unrelated to antimycin-producing strains; a selective GRP78 molecular chaperone down-regulator highlights the potential of this class as research probes. Synonyms: Salicylamide, N-(15-benzyl-10-sec-butyl-14-hydroxy-3-isopropyl-7,13,13-trimethyl-2,5,9,12-tetraoxo-1,4,8,11-tetraoxacyclopentadec-6-yl)-3-formamido-. Grades: >98% by HPLC. CAS No. 22862-63-1. Molecular formula: C36H46N2O12. Mole weight: 698.75. | |
Novobiocin Quick inquiry Where to buy Suppliers range | Novobiocin is found to bind at a second ATP-binding site in the C-terminal domain of Hsp90, thus disrupting the interaction of both p23 and Hsp70 co-chaperones with the Hsp90 complex. (IC50=700μmol/L). Synonyms: Streptonivicin; Inamycin; Albamycin; Cathomycin; Cardelmycin; Spheromycin; Antibiotic PA-93; Novobiocina; Benzamide, N-(7-((3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-beta-L-lyxo-hexopyranosyl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl)-4-hydroxy-3-(3-methyl-2-butenyl)-. Grades: >95%. CAS No. 303-81-1. Molecular formula: C31H36N2O11. Mole weight: 612.62. | |
Onalespib Quick inquiry Where to buy Suppliers range | Onalespib, also known as AT13387, is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. AT13387 selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Synonyms: AT13387; AT 13387; AT-13387. Grades: >98%. CAS No. 912999-49-6. Molecular formula: C24H31N3O3. Mole weight: 409.52. | |
PF-04929113 Quick inquiry Where to buy Suppliers range | PF-04929113, also known as SNX-5422, is a synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 inhibitor SNX-5542 is rapidly converted to SNX-2112, which accumulates in tumors relative to normal tissues. SNX-2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses. Synonyms: (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate; SNX5422; SNX-5422; SNX 5422; PF4929113; PF-4929113; PF 4929113; PF04929113; PF 04929113; PF-04929113. Grades: >97%. CAS No. 908115-27-5. Molecular formula: C25H30F3N5O4. Mole weight: 521.53. | |
QX77 Quick inquiry Where to buy Suppliers range | QX-77 is an activator of molecular chaperone-mediated autophagy (CMA). It can induce the up-regulation of Rab11 expression and up-regulate the expression of LAMP2A. Grades: 98%. CAS No. 1798331-92-6. Molecular formula: C16H13ClN2O2. Mole weight: 300.74. | |
Retaspimycin Quick inquiry Where to buy Suppliers range | Retaspimycin (IPI 504) is a small-molecule inhibitor of heat shock protein 90 (Hsp90) with antiproliferative and antineoplastic activities. Retaspimycin binds to and inhibits the cytosolic chaperone functions of Hsp90, which maintains the stability and functional shape of many oncogenic signaling proteins and may be overexpressed or overactive in tumor cells. Retaspimycin-mediated inhibition of Hsp90 promotes the proteasomal degradation of oncogenic signaling proteins in susceptible tumor cell populations, which may result in the induction of apoptosis. Synonyms: IPI-504; IPI 504; IPI504. Grades: >98%. CAS No. 857402-23-4. Molecular formula: C31H45N3O8. Mole weight: 587.70. | |
Retaspimycin Hydrochloride Quick inquiry Where to buy Suppliers range | Retaspimycin HCl is the hydrochloride salt of a small-molecule inhibitor of Hsp90 with antineoplastic and antiproliferative activities. Retaspimycin binds to and inhibits the cytosolic chaperone functions of Hsp90, which maintains the stability and functional shape of many oncogenic signaling proteins and has the possibililty to be overexpressed or overactive in tumor cells. Retaspimycin-mediated inhibition of Hsp90 promotes the proteasomal degradation of oncogenic signaling proteins in susceptible tumor cell populations, which may lead to the induction of apoptosis. Synonyms: retaspimycin hydrochloride; Retaspimycin HCl; IPI-504; 857402-63-2; IPI-504 HYDROCHLORIDE; CHEBI:71956; IPI 504; Retaspimycin hydrochloride [USAN]; Retaspimycin (Hydrochloride); 928Q33Q049; 857402-63-2 (HCl); [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6,20,22-trihydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16-oxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(22),8,12,14,18,20-hexaen-10-yl] carbamate; hydrochloride; Retaspimycin hydrochloride (USAN); 17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride. Grades: >95%. CAS No. 857402-63-2. Molecular formula: C31H48ClN3O8. Mole weight: 626.17. | |
RGA-C11 Quick inquiry Where to buy Suppliers range | It is a mild glucoside detergent that can be used as an alternative to GDN, digitalin and CHAPS. Due to the formation of small protein-detergent complexes (PDCs) with GPCRs and their enhanced stability, this detergent is conducive to the determination of protein structures, particularly for CryoEM-based structural study. Synonyms: resorcinarene-based amphiphile-C11. Grades: >99%. CAS No. 2390023-16-0. Molecular formula: C132H216O56. Mole weight: 2699.09. | |
Rocilinostat Quick inquiry Where to buy Suppliers range | Rocilinostat is an orally bioavailable histone deacetylase 6 (HDAC6) inhibitor with potential antineoplastic activity. It selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. Compared to non-selective HDAC inhibitor, Rocilinostat is able to reduce the toxic effects on normal, healthy cells. Uses: Antineoplastic agents. Synonyms: ACY-1215; ACY1215; ACY 1215; Rocilinostat; 2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide. Grades: 98%. CAS No. 1316214-52-4. Molecular formula: C24H27N5O3. Mole weight: 433.512. | |
SCH 529074 Quick inquiry Where to buy Suppliers range | SCH 529074 is a small molecule activator of mutant p53 that binds p53 DNA binding domain (Kd = 1-2 μM) and restores wild-type function to many oncogenic mutants by acting as a chaperone. SCH 529074 blocks ubiquitination of p53 by HDM2, and induces apoptosis in tumor cell lines. Synonyms: SCH 529074; SCH529074; SCH-529074; N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine. Grades: ≥98% by HPLC. CAS No. 922150-11-6. Molecular formula: C31H36Cl2N6. Mole weight: 563.56. | |
Squarunkin A hydrochloride Quick inquiry Where to buy Suppliers range | Squarunkin A is an inhibitor of UNC119 chaperone protein-cargo interaction. It inhibits the binding of a myristoylated peptide representing the N-terminus of Src kinase to UNC119A with an IC50 value of 10?nm. It binds to UNC119 proteins in cell lysate and interferes with the activation of Src kinase. Synonyms: Ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)amino)cyclobut-1-en-1-yl)amino)piperidine-1-carboxylate hydrochloride. Grades: ≥98% by HPLC. CAS No. 2253744-55-5. Molecular formula: C25H32F3N5O4·HCl. Mole weight: 560.01. | |
TPT-260 2HCl Quick inquiry Where to buy Suppliers range | TPT-260 2HCl is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation. Synonyms: TPT-260 Dihydrochloride; TPT-260 (Dihydrochloride); Thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride; [5- (Carbamimidoylsulfanylmethyl) thiophen-2-yl]methyl carbamimidothioate dihydrochloride. Grades: 98%. CAS No. 2076-91-7. Molecular formula: C8H14Cl2N4S3. Mole weight: 333.32. | |
White Petroleum Jelly Quick inquiry Where to buy Suppliers range | White petroleum jelly, also known as petrolatum, is a semisolid mixture of hydrocarbons obtained from petroleum. It is a white, odorless, and tasteless substance that is commonly used for its skin-softening and lubricating properties. Uses: Skin care: White petroleum jelly is commonly used as a moisturizer and skin protectant. It is used to treat and prevent dry, chapped, or cracked skin and can be applied directly to the skin or used in products such as lotions and creams.Lip care: White petroleum jelly is often used as a lip balm to treat and prevent dry, chapped lips. It can also be used to soften and moisturize the skin around the lips.Hair care: White petroleum jelly is sometimes used to tame frizz and add shine to hair. It can also be used to protect the hair and scalp from heat damage when used as a heat protectant.First aid: White petroleum jelly is often used as a first aid treatment for minor cuts, scrapes, and burns. It can help to protect the wound and prevent infection.Other uses: White petroleum jelly may also be used as a lubricant for mechanical parts, as a protective coating for wood and metal surfaces, and as a base for some makeup products. Group: Skin Protectant. Alternative Names: Petroleum jellyVaselinePetroleum waxMineral oil jellyParaffin wax. Grades: Technical grade, Food grade, Medical grade. CAS No. 8009-3-8. | |
WT-161 Quick inquiry Where to buy Suppliers range | WT-161 is a potent and specific HDAC6 inhibitor (IC50 = 0.40 nM). Consistent with WT-161 mediated hyperacetylation and inhibition of hsp90 chaperone function, treatment with WT-161 increased the intracellular levels of polyubiuitylated proteins in the cultured MCL JeKo-1 and Z138 cells. WT-161 was also noted to dose-dependently deplete the levels of cyclin D1 in the cultured MCL cells. Uses: Antineoplastic agents. Synonyms: (E) -8- (2- (4- (Diphenylamino) benzylidene) hydrazinyl) -N-hydroxy-8-oxooctanamide; WT161; WT 161; WT-161. CAS No. 1206731-57-8. Molecular formula: C27H30N4O3. Mole weight: 458.55. |