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| Product | Description | |
|---|---|---|
| CHAPS | CHAPS, a derivative of Cholic acid, is a zwitterionic detergent for solubilizing membrane proteins. CHAPS is used for stabilization of various protein-DNA complexes and can retain biochemical activity of proteins in solution [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 75621-03-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15435. |  |
| CHAPS | CHAPS. CAS No. 75621-03-3. Pack Sizes: Gram Quantities: 5 gm , 1 gm. Order Number: S112. |  www.prochemonline.com |
| CHAPS ( (3-[ (3-Cholamidopropyl) dimethylammonio]-1-propanesulfonate) ) | Non-denaturing zwitterionic detergent with cholic acid and sulfobetaine moieties, used to dissolve biological membranes, useful for protein extraction methods due to its ease of removal by dialysis or gel filtration. Low background UV absorption for protein detection.Designed by Good, et al., and typically referred to as Goods buffer useful in cell culture media formulations. Selection of biological buffer systems should include the following criteria: exclusion by biological membranes, low absorption between 240 and 700nm, chemically stable, and stable to temperature and concentration changes. Group: Biochemicals. Alternative Names: (3-[ (3-Cholamidopropyl) dimethylammonio]-1-propanesulfonate) ; N,N-Dimethyl-N-(3-sulfopropyl)-3-[[(3α,5 β, 7α, 12α)-3, 7, 12-trihydroxy-24-oxocholan-24-yl]amino]-1-propanaminium Inner Salt; CHAPS. Grades: Molecular Biology Grade. CAS No. 75621-03-3. Pack Sizes: 5g, 25g, 100g. Molecular Formula: C32H58N2O7S, Molecular Weight: 614.88. US Biological Life Sciences. |  Worldwide |
| CHAPS(3-((3-Cholamidopropyl)dimethylammonio)propanesulfonate) | 25g Pack Size. Group: Buffers. Formula: C32H58N2O7S. CAS No. 75621-03-3. Prepack ID 90005195-25g. Molecular Weight 614.88. See USA prepack pricing. |  |
| CHAPS(3-((3-Cholamidopropyl)dimethylammonio)propanesulfonate) | 5g Pack Size. Group: Buffers. Formula: C32H58N2O7S. CAS No. 75621-03-3. Prepack ID 90005195-5g. Molecular Weight 614.88. See USA prepack pricing. | |
| CHAPS hydrate | CHAPS hydrate, a derivative of Cholic acid, is a zwitterionic detergent for solubilizing membrane proteins. CHAPS hydrate is used for stabilization of various protein-DNA complexes and can retain biochemical activity of proteins in solution [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 331717-45-4. Pack Sizes: 500 mg; 1 g. Product ID: HY-15435A. | |
| CHAPSO | CHAPSO. CAS No. 82473-24-3. Pack Sizes: Gram Quantities: 1 gm. Order Number: S113. | www.prochemonline.com |
| CHAPSO | CHAPSO is a zwitterionic detergent that is thermally stable. CHAPSO is able to broaden the particle orientation distribution, enabling single-particle cryo-electron microscopy (cryo-EM) to produce isotropically uniform maps. CHAPSO can eliminate the directional bias of bacterial transcription complexes and help determine the structure of bacterial transcription complexes under cryo-electron microscopy [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 3-[3- (Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate. CAS No. 82473-24-3. Pack Sizes: 100 mg; 500 mg. Product ID: HY-W040201. | |
| CHAPSO | Non-denaturing zwitterionic detergent with cholic acid and sulfobetaine moieties, used to dissolve biological membranes, useful for protein extraction methods due to its ease of removal by dialysis or gel filtration. Low background UV absorption for protein detection. Group: Biochemicals. Alternative Names: (3-[ (3-Cholamidopropyl) dimethylammonio]-2-hydroxy-1-propanesulfonate) . Grades: Molecular Biology Grade. CAS No. 82473-24-3. Pack Sizes: 5g, 25g. US Biological Life Sciences. | Worldwide |
| 3-[ (3-Cholamidopropyl) dimethylammonio]-2-hydroxy-1-propanesulfonate | 3-[ (3-Cholamidopropyl) dimethylammonio]-2-hydroxy-1-propanesulfonate. Group: Biochemicals. Alternative Names: CHAPSO. Grades: Highly Purified. CAS No. 82473-24-3. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. US Biological Life Sciences. | Worldwide |
| ASB-16 (3- [N, N-Dimethyl (3-palmitoylaminopropyl) ammonio] propanesulfonate; Amidosulfobetaine-16) | A zwitterionic detergent useful for the solubilization of proteins including previously undetected membrane proteins. ASB-16 exhibits better protein solubilization properties than CHAPS. Also useful for solubilizing proteins for 2D-gel electrophoresis. Group: Biochemicals. Grades: Highly Purified. CAS No. 52562-29-5. Pack Sizes: 1g, 5g. US Biological Life Sciences. | Worldwide |
| Deoxy-bigCHAP | A non-ionic, cholamide-type detergent with properties comparable to CHAPS and CHAPSO but with reduced electrostatic interactions. Suited for ion exchange chromatography. Used for membrane solubilization. It is easily removed by dialysis and its absorption at UV region is very low. N, N-Bis[3- (D-gluconamido) propyl]deoxycholamide is used for membrane solubilization and proteomic analysis. Group: Biochemicals. Alternative Names: N,N-Bis[3-D-gluconamidopropyl]-deoxycholamide. Grades: Highly Purified. CAS No. 86303-23-3. Pack Sizes: 100mg, 500mg, 1g. Molecular Formula: C??H??N?O??, Molecular Weight: 862.06. US Biological Life Sciences. | Worldwide |
| Deoxy-BigCHAP | Deoxy-BigCHAP is a non-ionic detergent used in biochemistry and molecular biology, particularly for membrane protein studies. It is a derivative of BigCHAP (N,N-Bis(3-D-gluconamidopropyl)cholamide), differing by the absence of a hydroxyl group. This modification can influence its micelle formation and solubilization properties. Uses: A nonionic detergent with properties comparable to chaps and chapso but with reduced electrostatic interactions. suited for ion exchange chromatography. Synonyms: N,N'-[[[(3α,5β,12α)-3,12-Dihydroxy-24-oxocholan-24-yl]imino]di-3,1-propanediyl]bis[D-gluconamide]; deoxy-BIGCHAP; N,N'-Bis(3-D-gluconamidopropyl)deoxycholamide. Grade: ≥97%. CAS No. 86303-23-3. Molecular formula: C42H75N3O15. Mole weight: 862.06. |  |
| Deoxy-Bigchap (N,N-Bis[3-D-gluconamidopropyl]-deoxycholamide. ) | A nonionic detergent with properties comparable to CHAPS and CHAPSO but with reduced electrostatic interactions. Suited for ion exchange chromatography. Group: Biochemicals. Alternative Names: N,N-Bis[3-D-gluconamidopropyl]-deoxycholamide. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Native Rat Angiotensin Converting Enzyme | Angiotensin-converting enzyme (EC 3.4.15.1), or "ACE" indirectly increases blood pressure by causing blood vessels to constrict. It does that by converting angiotensin I to angiotensin II, which constricts the vessels. For this reason, drugs known as ACE inhibitors are used to lower blood pressure. ACE, angiotensin I and angiotensin II are part of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE is secreted in the lungs and kidneys by cells in the endothelium (inner layer) of blood vessels. Applications: Positive control. Group: Enzymes. Synonyms: ACE; Angiotensin Converting Enzyme; EC 3.4.15.1; dipeptid....1 M phosphate buffer and 300 mM NaCl at pH 8.3 at 37°C. Storage: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Form: Liquid in 100 mM phosphate buffered saline, 150 mM NaCl, pH 7.4 with 0.2mM CHAPS. Source: Rat lung. Species: Rat. ACE; Angiotensin Converting Enzyme; EC 3.4.15.1; dipeptidyl carboxypeptidase I; peptidase P; dipeptide hydrolase, peptidyl dipeptidase; angiotensin converting enzyme; kininase II; angiotensin I-converting enzyme; carboxycathepsin; dipeptidyl carboxypeptidase; "hypertensin converting enzyme" peptidyl dipeptidase I; peptidyl-dipeptide hydrolase; peptidyldipeptide hydrolase; endothelial cell peptidy |  |
| 116-9e | 116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)'s endogenous ATPase activity and the TAg-mediated activation of Hsp70. Uses: Designed for use in research and industrial production. Additional or Alternative Names: UPCMLD00WMAL2-11B; HMS2227G12; UPCMLD00WMAL2-11B:004; UPCMLD00WMAL2-11B:002; UPCMLD00WMAL2-11B:003. Product Category: Inhibitors. Appearance: Solid. CAS No. 831217-43-7. Molecular formula: C31H32N2O5. Mole weight: 512.6. Purity: 0.96. IUPACName: 6-[4-methyl-2-oxo-5-phenylmethoxycarbonyl-6-(4-phenylphenyl)-1,6-dihydropyrimidin-3-yl]hexanoic acid. Canonical SMILES: CC1=C(C(NC(=O)N1CCCCCC(=O)O)C2=CC=C(C=C2)C3=CC=CC=C3)C(=O)OCC4=CC=CC=C4. Product ID: ACM831217437. Alfa Chemistry ISO 9001:2015 Certified. Categories: 1160s in England. |  |
| 17-DMAG hydrochloride | 17-DMAG hydrochloride (Alvespimycin hydrochloride) is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Synonyms: 17-DMAG HCl; Alvespimycin HCl; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin Hydrochloride; 17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride; 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin Hydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride. Grade: >98%. CAS No. 467214-21-7. Molecular formula: C32H48N4O8.HCl. Mole weight: 653.21. | |
| 1-Deoxythiomannojirimycin | 1-deoxythiomannojirimycin is a formidable inhibitor of glycosidase enzymes, studied extensively for its capacity to treat a host of lysosomal storage diseases, including but not limited to Gaucher and Pompe. It assumes the role of a molecular chaperone, augmenting cellular activity linked with lysosomal enzymes that are otherwise indisposed due to disease. Synonyms: (2R,3S,4R,5S)-3,4,5-Trihydroxy-2-hydroxymethylthiane. Molecular formula: C6H12O4S. Mole weight: 180.22. | |
| 2, 4-Dimethyl Benzene sulfonyl Chloride | 2, 4-Dimethyl Benzene sulfonyl Chloride is used as a reagent in the synthesis of dimethyl benzimidazolones as potent and selective inhibitors of BRPF1 bromodomain. 2, 4-Dimethyl Benzene sulfonyl Chloride is also used as a reagent in the synthesis of quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for the treatment of Gaucher disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 609-60-9. Pack Sizes: 1g, 5g. Molecular Formula: C8H9ClO2S. US Biological Life Sciences. | Worldwide |
| 3-Aminobenzoic-d4 Acid | A chemoattractants against Pseudomonas strains. A reactant used in the preparation of influenza neuraminidase inhibitors, inhibitors of transthyretin amyloid fibril formation and Iihibitors of the protein chaperone Hsp90. Group: Biochemicals. Alternative Names: 3-Aminobenzenecarboxylic Acid; 3-Carboxyaniline; Aniline-3-carboxylic Acid; NSC 15012; m-Aminobenzoic Acid; m-Anthranilic Acid; m-Carboxyaniline; m-Carboxyphenylamine. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-Aminopropyl b-D-galactopyranoside | 3-Aminopropyl b-D-galactopyranoside is a valuable compound commonly used as a glycosylation compound and chaperone in various biochemistry studies. This compound serves as a precursor for the research and development of glycolipids and glycoproteins. Additionally, it has been employed to investigate lectin-carbohydrate interactions. Molecular formula: C9H19NO6. Mole weight: 237.25. | |
| 4-Phenylbutyric Acid | A chemical chaperone involved in protein-folding disorders. Group: Biochemicals. Alternative Names: Benzenebutanoic Acid; 4-Phenyl-n-butyric Acid; γ-Phenylbutanoic Acid; NSC 295. Grades: Highly Purified. CAS No. 1821-12-1. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 4-Phenylbutyric Acid-13C6 | Labeled 4-Phenylbutyric Acid , a chemical chaperone involved in protein-folding disorders. Group: Biochemicals. Alternative Names: Benzene-13C6-butanoic Acid; γ-Phenyl-13C6-butanoic Acid. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4-Phenylbutyric Acid-[d11] | 4-Phenylbutyric acid-d11 (4-PBA-d11) is the deuterium labeled 4-Phenylbutyric acid. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Uses: A chemical chaperone involved in protein-folding disorders. Synonyms: 4-Phenylbutyric D11 Acid; Benzene-d5-butanoic-d6 Acid; Benzenebutanoic Acid-d11; 4-Phenyl-n-butyric Acid-d11; γ-Phenylbutanoic Acid-d11; NSC 295-d11. Grade: ≥99%; ≥99% atom D. CAS No. 358730-86-6. Molecular formula: C10HD11O2. Mole weight: 175.27. | |
| Ac2-26 | Ac2-26 is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKK? protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model[1][2][3][4]. Uses: Scientific research. Group: Peptides. CAS No. 151988-33-9. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-P1098. | |
| Afegostat | Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase ( GCase ) in the endoplasmic reticulum (ER) with high affinity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: D-Isofagomine; Isofagomine. CAS No. 169105-89-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-14829. | |
| Afegostat D-Tartrate | Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase ( GCase ) in the endoplasmic reticulum (ER) with high affinity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: D-Isofagomine D-Tartrate; Isofagomine D-Tartrate. CAS No. 957230-65-8. Pack Sizes: 1 mg. Product ID: HY-14829E. | |
| alpha-2-macroglobulin receptor-associated protein precursor (252-260) | Alpha-2-macroglobulin receptor-associated protein precursor (252-260) is a peptide corresponding to residues 252-260 of alpha-2-macroglobulin receptor-associated protein precursor. Alpha-2-MRAP is a molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. Synonyms: Alpha-2-MRAP precursor (252-260). | |
| Ambroxol | Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NA-872. CAS No. 18683-91-5. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1039. | |
| Ambroxol hydrochloride | Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NA-872 hydrochloride. CAS No. 23828-92-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1039A. | |
| Amlexanox | Antiallergic. Anti-inflammatory. Antagonizes the angiogenic and mitogenic activity of FGF-1 through S100A13. Inhibits FGF-1 release. Binds to HSP90. Inhibits C-terminal chaperone activity. Induces an increase in nonsense-containing mRNAs amount in treated cells, leading to the synthesis of functional full-length proteins in an efficient manner. Selective inhibitor of TANK-binding Kinase 1 (TBK1) and IKKepsilon. Reversibly lowers weight and improves insulin sensitivity and reduces inflammation and attenuated hepatic steatosis in obese mices without affecting food intake. Group: Biochemicals. Alternative Names: 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid; Amoxanox; AA-673; CHX-3673; Aphthasol; Elics; Solfa. Grades: Highly Purified. CAS No. 68302-57-8. Pack Sizes: 25mg, 100mg, 500mg. Molecular Formula: C16H14N2O4, Molecular Weight: 298.29. US Biological Life Sciences. | Worldwide |
| AR7 | AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 80306-38-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101106. | |
| AR-7 | AR-7, also known as Atypical retinoid 7, was developed as a highly potent and selective enhancer of the chaperone-mediated autophagy (CMA) through antagonizing RARα. AR-7 was suggested to be used at 5-20 μM final concentration in vitro and in cellular assays. Synonyms: 7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine; AR 7; AR7; Atypical retinoid 7. CAS No. 80306-38-3. Molecular formula: C15H12ClNO. Mole weight: 257.71. | |
| Arimoclomol Maleic Acid | Arimoclomol is a orally administered drug used to treat amyotrophic lateral sclerosis and was later discovered to be a potential insulin resistance treatment and diabetic complications. Arimoclomol is believed to function by stimulating a normal cellular protein repair pathway through the activation of molecular chaperones. Arimoclomol could treat a broad range of diseases. Arimoclomol activates the heat shock response. It is believed to act at Hsp70. Group: Biochemicals. Alternative Names: N-{[(2R)-2-Hydroxy-3-piperidin-1-ylpropyl]oxy}pyridine-3-carboximidoyl Chloride 1-Oxide (2Z)-2-butenedioate; BRX 220; BRX 345. Grades: Highly Purified. CAS No. 289893-26-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Astemizole | Astemizole is a potent and orally active nonsedating-type histamine H1 receptor antagonist with IC50 value of 4 nM. It competitively binds to histamine H1 receptor sites in the uterus, gastrointestinal tract, bronchial muscle and blood vessels. It suppresses the formation of edema and pruritus caused by histamine. It has antipruritic and anticholinergic effects. It is also a potent blocker of ether-a-go-go-related gene (ERG) potassium channel blocker with IC50 value of 0.9 nM. It exhibits antimalarial activity in multidrug resistant strains in vitro with IC50 value of 227-734 nM. It has the potential for combination therapy with antivancer drugs in resistant leukemia. It is considerably less potent at muscarinic acetylcholine receptors with Ki value of 2.4 μM. It may be used as a potential antineoplastic agent for decreasing proliferation of various cancer cells. It may be used as a pharmacological chaperone to restore protein function for some mutated forms of hERG channels and correct folding defects. It was developed by Johnson & Johnson. Synonyms: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzim; Laridal; 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; Astemisan; Hismanal; Histamen; Paralergin; R 42512; Retolen; Waruzol. Grade: ≥99% by HPLC. CAS No. 68844-77-9. Molecular formula: C28H31FN4O. Mole weight: 458.57. | |
| Azoramide | Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It is a dual-function endoplasmic reticulum (ER) modulator in vitro. It improves endoplasmic reticulum (ER) protein-folding ability and stimulates the expression of ER chaperones to protect cells against ER stress in multiple systems. It regulates ER folding and secretion capacity without inducing ER stress. It might have the protective effects of enhancing chaperone expression and reducing protein synthesis without inducing cytotoxicity and apoptosis. It showed potent antidiabetic activity in two independent mouse models of obesity by protecting pancreatic β cell function against ER stress and improving insulin sensitivity in vivo. It improves glucose homeostasis in mice with genetic obesity and diet-induced obesity. Synonyms: N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide. Grade: >98%. CAS No. 932986-18-0. Molecular formula: C15H17ClN2OS. Mole weight: 308.82. | |
| Azoramide | Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 932986-18-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18705. | |
| benzyl 3-O-benzyl-2-acetamido-2-deoxy-α-D-glucopyranoside | Benzyl 3-O-benzyl-2-acetamido-2-deoxy-α-D-glucopyranoside, a well-known chemical compound within the biomedical industry, is frequently employed in the realms of diversified research. This versatile substrate proffers great potential for investigating the essential role of β-N-acetylhexosaminidase, an enzyme chaperoning lysosomal degradation. And yet, its profound value extends further still, as it may also be utilized to synthesize glycopeptides and explore the interaction between carbohydrates and proteins. Synonyms: N-[(2S,3R,4R,5S,6R)-5-hydroxy-6-(hydroxymethyl)-2,4-bis(phenylmethoxy)oxan-3-yl]acetamide; alpha-D-Glucopyranoside, phenylmethyl 2-(acetylamino)-2-deoxy-3-O-(phenylmethyl)-; Benzyl 3-O-benzyl-2-acetamido-2-deoxy-alpha-D-glucopyranoside; SCHEMBL5841546; IYODMICTBRMKGJ-LMYCIYFBSA-N; DTXSID901143418; AKOS003631747; Phenylmethyl 2-(acetylamino)-2-deoxy-3-O-(phenylmethyl)-|A-D-Glucopyranoside; Phenylmethyl 2-(acetylamino)-2-deoxy-3-O-(phenylmethyl)--D-Glucopyranoside; Phenylmethyl 2-(acetylamino)-2-deoxy-3-O-(phenylmethyl)-alpha-D-Glucopyranoside. Grade: 98%. CAS No. 14146-27-1. Molecular formula: C22H27NO6. Mole weight: 401.45. | |
| Benzyl Migalastat | An impurity of Migalastat. Migalastat is an oral pharmacological chaperone used to treat Fabry disease, a rare genetic lysosomal storage disorder caused by deficiencies in the enzyme alpha-galactosidase A. Synonyms: 1-Deoxygalactonojirimycin Tetrabenzyl Ether; Piperidine, 3,4,5-tris(phenylmethoxy)-2-[(phenylmethoxy)methyl]-, (2R,3S,4R,5S)-; (2R,3S,4R,5S)-3,4,5-Tris(phenylmethoxy)-2-[(phenylmethoxy)methyl]piperidine; Piperidine, 3,4,5-tris(phenylmethoxy)-2-[(phenylmethoxy)methyl]-, [2R-(2α,3α,4α,5β)]-; Tetrabenzyl Migalastat. Grade: ≥95%. CAS No. 167904-18-9. Molecular formula: C34H37NO4. Mole weight: 523.66. | |
| BIX | BIX is a BiP (Hsp70-5) ER chaperone inducer that induces BiP expression in vitro and in vivo. BIX protects against ER-stress induced cell death in neuronal and retinal cell lines, and also protects against ischaemia-induced hippocampal cell death in vivo. Synonyms: 2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid; Thiocyanic acid,2-(3,4-dihydroxyphenyl)-2-oxoethyl ester. Grade: ≥98% by HPLC. CAS No. 101714-41-4. Molecular formula: C9H7NO3S. Mole weight: 209.22. | |
| Blood Group H-BSA (15 atom spacer) | Blood Group H-BSA (15 atom spacer) is an indispensable biomolecular tool that plays an important role in biomedicine by enabling improved detection and rigorous analysis of blood group antigens, which are fundamental to understanding human immune function. Utilizing this product in experimental settings provides valuable insights into the molecular recognition of H blood group antigens by chaperone and polymerase proteins, with potential applications in cancer diagnosis and treatment. | |
| CA77.1 | CA77.1 is a brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD). Synonyms: CA. CAS No. 2412270-22-3. Molecular formula: C16H12ClN3O. Mole weight: 297.74. | |
| CA77.1 | CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in?lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's?disease research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2412270-22-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134923. | |
| CBL0137 | CBL0137, a curaxin compound, is a histone chaperone facilitates chromatin transcription (FACT) inhibitor. CBL0137 downregulates NF- B and activates p53. CBL0137 restores both histone H3 acetylation and trimethylation. CBL0137 is an anticancer agent. CBL0137 induces cancer cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Curaxin 137; CBL-C137. CAS No. 1197996-80-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935. | |
| CBL0137 | CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 μM and inhibits NF-κB with an EC50 of 0.47 μM. It also inhibits histone chaperone FACT (facilitates chromatin transcription) and MYC signal. Synonyms: CBL0137; CBL-0137; CBL 0137; CBLC137; CBLC-137; CBLC 137; Curaxin 137; 1,1'-(9-(2-(Isopropylamino)ethyl)-9H-carbazole-3,6-diyl)diethanone; 1-[6-acetyl-9-[2-(propan-2-ylamino)ethyl]carbazol-3-yl]ethanone. CAS No. 1197996-80-7. Molecular formula: C21H24N2O2. Mole weight: 336.435. | |
| CBL0137 hydrochloride | CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC 50 s of 0.37 and 0.47 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Curaxin-137 hydrochloride; CBL-C137 hydrochloride. CAS No. 1197397-89-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935A. | |
| Chaperonin 10 from Escherichia coli | ?95.0% (SDS-PAGE), recombinant, expressed in E. coli overproducing strain, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Chaperonin 60 from Escherichia coli | >95% (SDS-PAGE), recombinant, expressed in E. coli overproducing strain, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| chaperonin ATPase | Multisubunit proteins with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or entry into mitochondria and chloroplasts. Molecular masses of subunits ranges from 10-90 kDa. They are a subclass of molecular chaperones that are related to EC 3.6.4.8 (proteasome ATPase). Group: Enzymes. Synonyms: chaperonin. Enzyme Commission Number: EC 3.6.4.9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4711; chaperonin ATPase; EC 3.6.4.9; chaperonin. Cat No: EXWM-4711. | |
| Claficapavir | Claficapavir, a specific nucleocapsid protein (NC) inhibitor with an IC50 of about 1 μM, strongly binds to HIV-1 NC (Kd = 20 nM) thereby inhibiting the chaperone properties of NC and resulting in good antiviral activity against HIV-1. Synonyms: A1752; 3-Thiazolidinepropanoic acid, 5-[[5-(4-chlorophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-, (5Z)-; (Z)-3-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid. Grade: >98% (HPLC). CAS No. 2055732-24-4. Molecular formula: C17H12ClNO4S2. Mole weight: 393.86. | |
| Cucurbitacin D | Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis , exhibiting anti-tumor and anti-inflammatory effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 3877-86-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N1986. | |
| Cuproptosis Compound Library | 411 active small molecules associated with cuproptosis for high-throughput and high-intensity screening. - Targeting Ferredoxin 1 (FDX1), Antioxidant 1 Copper Chaperone (ATOX1), CCS (copper chaperones), mitochondrial respiration, etc. - Some compounds are FDA-approved. - Detailed instructions, compound structure, target information, description of activity, etc. - Various detection techniques such as NMR, HPLC/LCMS to ensure the correct structure and high purity of the product and reduce false positives. Uses: Scientific use. Product Category: L8710. Categories: Cuproptosis Compounds Libraries. |  |
| Curcuma Xanthorrhiza (Temulawak) Oil - CO2 | Temulawak is extracted from dried Curcuma xanthorrhiza rhizomes (roots) organically grown in Java, Indonesia. The producer advises that Javanese Turmeric Co2 is a beneficial ingredient in skin care formulations due to its ability to soothe dry, irritated or chapped skin. Skin conditions of acne, eczema, and psoriasis benefit from the soothing and antimicrobial activity of Javanese Turmeric Co2. It may also be used in oral care products because of the antimicrobial efficacy especially against streptococcus mutans. General use: Massage oil, perfume, bath and body skin care, spa treatment oils and creams, soaps, candles. Uses: Pharmaceutical. Group: Plant Extracts. INCI Names: Curcuma Xanthorrhiza Root Oil. Grades: INDUSTRIAL GRADE. CAS No. 89998-05-0. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: CU-003. Olfactive Profile: Herbaceous, spicy. EC No: 289-742-6. Origin: Indonesia. |  New Jersey |
| Derrubone | Derrubone is a prenylated isoflavone, a type of flavonoid. It was originally isolated from the Indian tree Derris robusta.It has potential application as an inhibitor of Hsp90 to its function as a chaperone protein. Synonyms: 5,7-Dihydroxy-3',4'-methylenedioxy-6-prenylisoflavone. Grade: >98%. CAS No. 22044-58-2. Molecular formula: C21H18O6. Mole weight: 366.37. | |
| DS-2248 | DS-2248 is an orally active and small molecule inhibitor of Hsp90, with potential antineoplastic activity. Upon oral administration, Hsp90 inhibitor DS-2248 specifically blocks Hsp90, which inhibits its chaperone function and promotes the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. This may result in an inhibition of tumor cell proliferation. Synonyms: DS2248; DS-2248; DS 2248. Grade: >98%. CAS No. 1696408-04-4. | |
| FDW028 | FDW028 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2768426-49-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155747. | |
| Ganetespib | Ganetespib, also known as STA-9090, is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor STA-9090 binds to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional Hsp90 for maintenance. Hsp90, a 90 kDa molecular chaperone upregulated in a variety of tumor cells, plays a key role in the conformational maturation, stability and function of "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used as a surrogate marker for Hsp90 inhibition. Synonyms: STA-9090; STA 9090; STA9090. Grade: >98%. CAS No. 888216-25-9. Molecular formula: C20H20N4O3. Mole weight: 364.40. | |
| Geldanamycin (Streptomyces hygroscopicus) 98+% | Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. A potent antitumor 1 and potent inhibitor of p60c-crc tyrosine kinase, erb B2,2 EGF receptor tyrosine kinase and non-receptor tyrosine kinases. 3, Geldanamycin binds specifically and inhibits the chaperone protein Hsp90.2. Group: Biochemicals. Alternative Names: 9, 13-Dihydroxy-8, 14, 19-trimethoxy-4, 10, 12, 16-tetramethyl-2-azabicyclo[16. 3. 1]docosa-4, 6, 10, 18, 21-pentaene-3, 20, 22-trione 9-Carbamate; (+)-Geldanamycin; NSC 122750; NSC 212518; BRN1633093. Grades: Highly Purified. CAS No. 30562-34-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| grixazone synthase | A type 3 multi copper protein. The enzyme, isolated from the bacterium Streptomyces griseus, catalyses an 8 electron oxidation. Activation of the enzyme requires a copper chaperone (GriE). It also acts on 3-amino-4-hydroxybenzaldehyde, giving grixazone A. The second aldehyde group is presumably lost as formate. The enzyme also catalyses the reaction of EC 1.10.3.4 o-aminophenol oxidase. Group: Enzymes. Synonyms: GriF. Enzyme Commission Number: EC 1.10.3.15. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0481; grixazone synthase; EC 1.10.3.15; GriF. Cat No: EXWM-0481. | |
| HA15 | HA15 is a potent and specific inhibitor of ER chaperone BiP/GRP78/HSPA5, inhibits the ATPase activity of BiP, with anti-cancerous activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1609402-14-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100437. | |
| HA15-Biotin | HA15-Biotin can be used for proteomic analysis and is a chemical probe consisting of HA15 and biotin attached to the HA15 amide portion. It shows similar activity level to HA15. HA15 is a potent and specific inhibitor of ER chaperone BiP/GRP78/HSPA5, which can inhibit the ATPase activity of BiP, and has anti-cancerous activity. Synonyms: 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[6-[[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]amino]-6-oxohexyl]hexahydro-2-oxo-, (3aS,4S,6aR)-. CAS No. 1965310-52-4. Molecular formula: C37H45N7O5S3. Mole weight: 763.99. | |
| Heat shock 70 kDa protein 1 (391-399) | Heat shock 70 kDa protein 1 (391-399) is a fragment of Heat shock 70 kDa protein 1. As a member of the heat shock protein 70 family and a chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or degrade mutant proteins. Synonyms: HSP70-1 (391-399). | |
| Heat shock 70 kDa protein 1 (393-401) | Heat shock 70 kDa protein 1 (393-401) is a fragment of Heat shock 70 kDa protein 1. As a member of the heat shock protein 70 family and a chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or degrade mutant proteins. Synonyms: HSP70-1 (393-401). | |
| Herbimycin A (Herbimycin, Antibiotic TAN 420F) | Herbimycin A is the major analogue of a complex of benzoquinone ansamycin antibiotics isolated from a Streptomyces hygroscopicus. Herbimycin A inhibits the 90-kD heat-shock protein (Hsp90) which provides essential chaperone support to various signal transduction molecules, including including certain steroid hormone receptors and select kinases. Herbimycin has also been shown to inhibit protein tyrosine kinase and angiogensis. Group: Biochemicals. Alternative Names: Herbimycin, Antibiotic TAN 420F. Grades: Highly Purified. CAS No. 70563-58-5. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| HSF1A | HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1)[1]. HSF1A also acts as a specific inhibitor of TRiC/CCT. Chaperonin TCP-1 ring complex (TRiC)/chaperonin containing TCP-1 (CCT) plays a pivotal role in toxin translocation and/or refolding[4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1196723-93-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103000. | |
| HSP27 inhibitor J2 | HSP27 inhibitor J2 is an HSP27 inhibitor that can significantly induce abnormal formation of HSP27 dimer and inhibit the production of HSP27 giant polymers, thereby inhibiting the chaperone function of HSP27 and reducing its cellular protective function. It significantly enhances the anti-proliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition. Synonyms: J2; 4H-1-Benzopyran-4-one, 5-hydroxy-2-methyl-7-(2-thiiranylmethoxy)-; 5-Hydroxy-2-methyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one; 5-Hydroxy-2-methyl-7-(2-thiiranylmethoxy)-4H-chromen-4-one. Grade: ≥95%. CAS No. 2133499-85-9. Molecular formula: C13H12O4S. Mole weight: 264.30. | |
| HSP27 inhibitor J2 | HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: J2. CAS No. 2133499-85-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124653. | |
| HSP47 inhibitor III | An inhibitor of the collagen-specific chaperone HSP47 with IC50 of 3.1 μM. HSP47 inhibitor III suppressed collagen type I expression in human and mouse cells and suppressed the viability and migration of lung fibroblasts. Synonyms: CBTC; Methyl 6-chloro-2-oxo-3H-1,2λ4,3-benzodithiazole-4-carboxylate. Grade: 98%. CAS No. 287917-38-8. Molecular formula: C8H6ClNO3S2. Mole weight: 263.72. | |
| HSP70 Activator II, YM-08 ( (2Z, 5E) -3-ethyl-5- (3-methylbenzo[d]thiazol-2 (3H) -ylidene) -2- (pyridin-2-ylmethylene) thiazolidin-4-one, Heat Shock 70kD Protein Activator II, Hsp70 Chemical Co-Chaperone II, YM-08, YM08, YM8) | A cell-permeable, neutrally charged, pyridinium-to-pyridine substituted YM-01 and MKT-077 structural analog that exhibits higher HSP70-binding affinity, but reduced tau degradation-promoting potency in cultures (% degradation of p-tau/total tau = 42/64, 88/89, and 81/80 in HeLaC3 with 30uM YM-08, MKT-077, or YM-01, respectively) and weaker anti-cancer activity (IC50 against MDA-MB-231/MCF10A/MCF7 inuM = 1.4/3.0/2,2/MKT-077, 2.0/3.3/5.2/YM-01, and 8.5/7.8/10.5/YM-08 in 72h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| HSP990 | HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (HSP90) with potential antineoplastic activity. HSP990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. HSP90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses. Synonyms: NVP-HSP990; NVP HSP990; NVPHSP990; HSP 990; HSP-990. Grade: >98%. CAS No. 934343-74-5. Molecular formula: C20H18FN5O2. Mole weight: 379.39. | |
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