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| Product | Description | |
|---|---|---|
| 5-Bromo-5-chloro-6-hydroxy-dihydro-pyrimidine-2,4-dione | Heterocyclic Organic Compound. CAS No. 119200-39-4. Purity: 0.96. Catalog: ACM119200394. |  |
| 5-Bromo-6-chloro-4-hydroxy-2-methylpyrimidine - NEW PRODUCT | Heterocyclic Organic Compound. Alternative Names: 5-Bromo-6-chloro-2-methylpyrimidin-4-ol. CAS No. 105806-11-9. Molecular formula: n1c(c(c(nc1C)Cl)Br)O. Mole weight: 223.4566. Purity: 0.96. IUPACName: 5-bromo-6-chloro-2-methyl-1H-pyrimidin-4-one. Canonical SMILES: CC1=NC(=O)C(=C(N1)Cl)Br. Catalog: ACM105806119. | |
| 5-Chloro-2-hydroxy-pyrimidine | 5-Chloro-2-hydroxy-pyrimidine (CAS# 54326-16-8) is used to prepare dimethoxy-pyrrolidylquinazolines as brain penetrable PDE10A inhibitors. It is also used in the synthesis of platinum(II) hydroxypyrimidinato ethylenediamine tetranuclear metallacalix[4]arene complexes. Synonyms: 5-Chloropyrimidin-2-ol. Grades: ≥ 98 %. CAS No. 54326-16-8. Molecular formula: C4H3ClN2O. Mole weight: 130.53. |  |
| 5-Chloro-2-hydroxy-pyrimidine 99+% (HPLC) | 5-Chloro-2-hydroxy-pyrimidine 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. |  Worldwide |
| Mirk/Dyrk1B Inhibitor, Compound A (N- (2-Chloro-5- (3-chlorobenzylcarbamoyl) phenyl) -2-methoxy-7-oxo-7, 8-dihydropyrido[2, 3-d]pyrimidine-6-carboxamide, N- (2-Chloro-5- ( (3-chlorobenzyl) carbamoyl) phenyl) -7-hydroxy-2-methoxypyrido[2, 3-d]pyrimidine-6-carboxamide) | A cell-permeable di hydropyridopyrimidine-carboxamide compound that acts as a potent and reversible inhibitor of Mirk/Dyrk1B and Dyrk1A kinases (IC50 = 68 and 22nM). Exhibits very high selectivity for Mirk/Dyrk1B compared to Abl, Flt3, and MARK1 (64, 56 and 73% inhibition at 10uM, respectively) and a panel of 46 other kinases. Shown to induce activation of caspase-3 and sensitize tumor cells to the action of gemcitabine and cisplatin, possibly by de-stabilizing p27. Preferentially increases cycling in Mirk-elevated quiescent pancreatic cancer cells (SU86.86, Panc1, AsPc1, and SW620 at ~1uM). Also, shown to increase level of superoxides in quiescent pancreatic tumor cells (Panc1, SU86.86, and AsPc1) by blocking SOD2 and SOD3 activities. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 1-(2'-Deoxy-2'-chloro-b-L-arabinofuranosyl)-thymine | 1-(2'-Deoxy-2'-chloro-b-L-arabinofuranosyl)-thymine, also known as 2'-C-C-AraT, is a nucleoside analog utilized in biomedical research particularly in antiviral and anticancer therapy studies. It has demonstrated inhibitory effects against Hepatitis B viral replication. Synonyms: 1-(2'-Deoxy-2'-chloro-β-L-arabinofuranosyl)-thymine; 1-[(2S,3R,4S,5S)-3-chloro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 1-(2-Chloro-2-deoxy-β-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione. Molecular formula: C10H13ClN2O5. Mole weight: 276.67. | |
| 2'-Chloro-2'-deoxyuridine | 2'-Chloro-2'-deoxyuridine (CAS# 4753-04-2 ) is a useful research chemical. Synonyms: 2'-Deoxy-2'-chlorouridine; 1-((2R,3R,4R,5R)-3-Chloro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione. Grades: ≥ 95 %. CAS No. 4753-4-2. Molecular formula: C9H11ClN2O5. Mole weight: 262.65. | |
| 2'-Deoxy-2'-fluoro-L-uridine | 2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside compound. 2'-Deoxy-2'-fluoro-l-uridine is a potent, selective viral RNA polymerase inhibitor, thereby inhibiting RNA virus replication. Group: Inhibitors. Alternative Names: (S)-2-chloro-butyric acid dimethylamide; L-2-Chlor-N,N-dimethyl-butyramid; L-2-deoxy-2-fluorouridine; (S)-2-Chlor-buttersaeure-dimethylamid; 2-Chloro-N,N-dimethylbutyramide; Butanamide,2-chloro-N,N-dimethyl; 2-fluoro-L-uridine. CAS No. 622785-69-7. Molecular formula: C9H11FN2O5. Mole weight: 246.2. Appearance: White to off-white solid. Purity: 0.96. IUPACName: 1-[(2R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione. Canonical SMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)F. Catalog: ACM622785697. | |
| 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one | Heterocyclic Organic Compound. Alternative Names: 3-(2-CHLOROETHYL)-9-HYDROXY-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE;3-(2-Chloroethyl)-2-methyl-9-hydroxy-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-one;3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one;3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-α]pyrimidin-4-one;3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one;3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one ,98%;Paliperidone Intermediate 1;3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one. CAS No. 130049-82-0. Molecular formula: C11H15ClN2O2. Mole weight: 242.7. Catalog: ACM130049820. | |
| 5-Chloro-2'-deoxyuridine | It is an anticancer agent and a radio-sensitizing agent for cancer treatment. Synonyms: 2'-Deoxy-5-chlorouridine; 5-Chlorodeoxyuridine; Chlorodeoxyuridine; NSC 749426; 5-chloro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione. Grades: ≥95%. CAS No. 50-90-8. Molecular formula: C9H11ClN2O5. Mole weight: 262.65. | |
| Avanafil Impurity 37 | Avanafil Impurity 37. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((3-chloro-4-methoxybenzyl)amino)-2-hydroxy-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide. CAS No. 1452128-53-8. Molecular Formula: C18H17ClN6O3. Mole Weight: 400.82. Catalog: APB1452128538. |  |
| Avanafil Impurity 38 | Avanafil Impurity 38. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((3-chloro-4-hydroxybenzyl)amino)-2-hydroxy-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide. Molecular Formula: C17H15ClN6O3. Mole Weight: 386.79. Catalog: APB02767. | |
| cyanuric acid amidohydrolase | Along with EC 3.5.1.54 (allophanate hydrolase) and EC 3.5.1.84 (biuret amidohydrolase), this enzyme forms part of the cyanuric-acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine], in bacteria. This is a key enzyme in the pathway, catalysing the ring cleavage of cyanuric acid. The enzyme is specific for cyanuric acid as substrate as neither the structurally related compounds ammeline (2,4-diamino-6-hydroxy-s-triazine) and ammelide (2-amino-4,6-dihydroxy-s-triazine) nor a number of pyrimidine compounds, such as uracil and cytosine, can act as substrates. Group: Enzymes. Synonyms: AtzD. Enzyme Commission Number: EC 3.5.2.15. CAS No. 132965-78-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4498; cyanuric acid amidohydrolase; EC 3.5.2.15; 132965-78-7; AtzD. Cat No: EXWM-4498. |  |
| 1-(2'-Chloro-2'-deoxy-b-D-arabinofuranosyl)cytosine | 1-(2'-Chloro-2'-deoxy-b-D-arabinofuranosyl)cytosine is an antineoplastic biomolecule used in cancer research. It's an analog of the nucleoside cytosine, inhibiting DNA synthesis to stop tumor cells replication. Synonyms: 2(1H)-Pyrimidinone, 4-amino-1-(2-chloro-2-deoxy-beta-D-arabinofuranosyl)-; 4-Amino-1-(2-chloro-2-deoxy-.beta.-D-arabinofuranosyl)pyrimidin-2(1H)-one; 4-amino-1-[(2R,3S,4R,5R)-3-chloro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one. CAS No. 58461-30-6. Molecular formula: C9H12ClN3O4. Mole weight: 261.66. | |
| 1-Benzyl-2-chloro-1H-indole-3-carboxaldehyde | 1-Benzyl-2-chloro-1H-indole-3-carboxaldehyde is an intermediate in synthesizing 2,3,4,10-Tetrahydro-1H-indolo[2,3-b][1,8]naphthyridin-2-ol (T294270), a derivative of 6, 7, 8, 9-Tetrahydro-7-hydroxy-5-methyl-3-phenyl-pyrido[3, 2:4, 5]imidazo[1, 2-a]pyrimidinium Chloride (H957770), a carcinogen used in the study of intestinal bacteria metabolism. Created through the heat processing of food. Group: Biochemicals. Grades: Highly Purified. CAS No. 77655-46-0. Pack Sizes: 500mg, 1g. Molecular Formula: C16H12ClNO. US Biological Life Sciences. | Worldwide |
| 2'-Chloro-2'-deoxycytidine | 2'-Chloro-2'-deoxycytidine is a nucleoside analogue, orchestrating its antineoplastic prowess via impeding DNA synthesis and evoking apoptosis exclusively within malignant cells. Synonyms: 2'-Deoxy-2'-chloro-cytidine; 4-Amino-1-((2R,3R,4R,5R)-3-chloro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one. Grades: ≥95%. CAS No. 10212-19-8. Molecular formula: C9H12ClN3O4. Mole weight: 261.66. | |
| 3-? [2-?Chloro-?1-? (phenylmethyl) ?-?1H-?indol-?3-?yl] ?-?2-?cyano-?2-?propenoic Acid | 3-? [2-?Chloro-?1-? (phenylmethyl) ?-?1H-?indol-?3-?yl] ?-?2-?cyano-?2-?propenoic Acid is an intermediate in synthesizing 2,3,4,10-Tetrahydro-1H-indolo[2,3-b][1,8]naphthyridin-2-ol (T294270), a derivative of 6, 7, 8, 9-Tetrahydro-7-hydroxy-5-methyl-3-phenyl-pyrido[3, 2:4, 5]imidazo[1, 2-a]pyrimidinium Chloride (H957770), a carcinogen used in the study of intestinal bacteria metabolism. Created through the heat processing of food. Group: Biochemicals. Grades: Highly Purified. CAS No. 188034-08-4. Pack Sizes: 25mg, 50mg. Molecular Formula: C21H17ClN2O2. US Biological Life Sciences. | Worldwide |
| 3-(2-Chloroethyl)-6,7,8,9-Tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one | 3-(2-Chloroethyl)-6,7,8,9-Tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-(2-Chloroethyl)-9-hydroxy-2-methyl-4H-Pyrido[1,2-a]pyrimidin-4-one Hydrochloride | 3-(2-Chloroethyl)-9-hydroxy-2-methyl-4H-Pyrido[1,2-a]pyrimidin-4-one Hydrochloride is an intermediate in the synthesis of analog of Paliperidone (P141000), a combined serotonin and dopamine receptor antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 849727-62-4. Pack Sizes: 25mg, 250mg. Molecular Formula: C11H12Cl2N2O2. US Biological Life Sciences. | Worldwide |
| 5-Amino-2-chlorophenol | 5-Amino-2-chlorophenol is used in the synthesis of antimalarial quinolones. Also used in the synthesis of potent anti-HIV agents based upon pyrimidinylphenylamine 1. Group: Biochemicals. Alternative Names: 2-Chloro-5-aminophenol; 3-Amino-6-chlorophenol; 3-Hydroxy-4-chloroaniline; 5-Amino-2-chlorophenol. Grades: Highly Purified. CAS No. 6358-6-1. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| ALS-8176 (active form) | ALS-8176 (active form), a 4'-substituted cytidine analogue, is a potent, selective RSV polymerase inhibitor. It has an EC50 of 0.15 μM in the RSV replicon assay and an IC50= 0.02 μM due to its corresponding 5'-triphosphate in the RSV polymerase assay. Synonyms: 4-amino-1-[(2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-oneALS-8176 (active form); ALS-8112; ALS8112; ALS 8112. UNII-7795987MKM7795987MKMCHEMBL3417243SCH EMBL15070479CS-5472; HY-12983; CS 5472; HY 12983; CS5472; HY129834'-Chloromethyl-2'-deoxy-2'-fluorocytidineCytidine. Grades: 99.67%. CAS No. 1445379-92-9. Molecular formula: C10H13ClFN3O4. Mole weight: 293.68. | |
| AZ 10397767 | AZ 10397767 is a potent CXCR2 antagonist (IC50 = 1 nM). It significantly reduced the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models and slows growing tumors. It attenuates oxaliplatin-induced NF-κB activation and increases oxaliplatin cytotoxicity, thus potentiates oxaliplatin-induced apoptosis in AIPC cells. It may be potential for treating cystic fibrosis and chronic obstructive pulmonary disease. It is orally bioavailable. Synonyms: AZ-10397767; AZ 10397767; AZ10397767. 5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one. Grades: ≥98% by HPLC. CAS No. 333742-63-5. Molecular formula: C15H14ClFN4O2S2. Mole weight: 400.88. | |
| Demethylpiperazinyl Desethyl Sildenafil Sulfonyl Chloride | Sildenafil derivative. Used in the preparation purinone derivatives for treatment of precancerous lesions and as cardiovascular agents. Group: Biochemicals. Alternative Names: 3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-hydroxy-benzenesulfonyl Chloride; 5-(5-Chlorosulfonyl-2-hydroxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one. Grades: Highly Purified. CAS No. 139756-27-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Hydroxy Chlorodenafil | Hydroxy Chlorodenafil is a related compound of Sildenafil as phosphodiesterase inhibitor. Group: Biochemicals. Alternative Names: 5-[5-(2-Chloro-1-hydroxyethyl)-2-ethoxyphenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one. Grades: Highly Purified. CAS No. 1391054-00-4. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| Ipatasertib HCl | Ipatasertib, also known as GDC-0068, is a highly selective pan-Akt inhibitor targeting Akt1/2/3 (IC50= 5 nM/18 nM/8 nM in cell-free assays) with 620-fold selectivity over PKA. Ipatasertib is advancing in clinical development including a Phase 3 trial in patients with prostate cancer and three Phase 2 trials in patients with breast cancer, gastric cancer and prostate cancer. Synonyms: (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one hydrochloride.; GDC0068; GDC-0068; GDC 0068; RG7440; RG-7440; RG 7440; Ipatasertib; Ipatasertib hydrochloride, Ipatasertib HCl. CAS No. 1489263-16-2. Molecular formula: C24H33Cl2N5O2. Mole weight: 494.46. | |
| LIT-927 | LIT-927 is an orally available neutraligand of CXCL12. It reduces eosinophil recruitment in a murine model of allergic airway hypereosinophilia, displaying anti-inflammatory effects. Synonyms: 4-(4-Chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)pyrimidin-2(1H)-one. CAS No. 2172879-52-4. Molecular formula: C17H13ClN2O3. Mole weight: 328.75. | |
| p38 MAPK-IN-2 | An inhibitor of p38 kinase. Synonyms: Ethanone, 1-[4-[5-(4-chloro-2-fluorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy-; 1-[4-[3-(4-chloro-2-fluorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-hydroxyethanone. CAS No. 635725-16-5. Molecular formula: C20H19ClFN5O2. Mole weight: 415.85. | |
| Paliperidone Impurity 1 | An impurity of Paliperidone which is the primary active metabolite of the older antipsychotic risperidone. Synonyms: 3-(2-Chloro ethyl )-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one HCl; Paliperidone Tetradehydro Chloroethyl Impurity. Grades: > 95%. CAS No. 260273-82-3. Molecular formula: C11H11ClN2O2. Mole weight: 238.68. | |
| Paliperidone Impurity 1 | Paliperidone Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one. CAS No. 130049-82-0. Molecular Formula: C11H15ClN2O2. Mole Weight: 242.7. Catalog: APB130049820. | |
| PF 06273340 | PF 06273340 is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively. PF 06273340 is selective for Trk over a panel of ion channels, receptors and other enzymes. It shows efficacy in a rodent model of inflammatory pain. Synonyms: N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide; PF-06273340; PF 06273340; PF06273340; PF-6273340; PF 6273340; PF6273340. Grades: ≥98% by HPLC. CAS No. 1402438-74-7. Molecular formula: C23H22ClN7O3. Mole weight: 479.93. | |
| Ticagrelor Related Compound 18 | An impurity of Ticagrelor which is a reversible P2Y12 receptor antagonist and is unique in its greater and more rapid and consistent, yet reversible, inhibition of the ADP receptor. Synonyms: (1S,2S,3S,5R)-3-(2-((6-chloro-5-hydroxy-2-(propylthio)pyrimidin-4-yl)oxy)ethoxy)-5-(7-(((1R,2R)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)cyclopentane-1,2-diol. Grades: > 95%. Molecular formula: C30H35ClF2N8O5S2. Mole weight: 725.23. | |
| Zunsemetinib | Zunsemetinib is a tyrosine kinase inhibitor. Synonyms: [1(2H),4'-Bipyridin]-2-one, 3-chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-2'-[2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl]-5',6-dimethyl-, (-)-. Grades: >98%. CAS No. 1640282-42-3. Molecular formula: C25H22ClF2N5O3. Mole weight: 513.92. | |
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