Cisplatin Suppliers USA
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Product | Description | |
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cisplatin Quick inquiry Where to buy Suppliers range | cisplatin. Group: Heterocyclic Organic Compound. CAS No. 1902-3-19. Product ID: ACM809. | |
Cisplatin Quick inquiry Where to buy Suppliers range | Cisplatin induces cytotoxic by interaction with DNA to form DNA adducts which activate several signal transduction pathways, including Erk, p53, p73, and MAPK, which culminates in the activation of apoptosis. It is used in several types of cancer. Uses: Antineoplastic agent. Synonyms: (SP-4-2)-diamminedichloro-platinum. Grades: >98%. CAS No. 15663-27-1. Molecular formula: Cl2H6N2Pt. Mole weight: 300.05. | |
Cisplatin Quick inquiry Where to buy Suppliers range | Chemotherapeutic agent for use in preventing the advancement of testicular cancer. Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links. Group: Biochemicals. Alternative Names: cis-Dichlorodiammine platinum(II); cis-Platinum(II) diammine dichloride; Cisplatin; Briplatin, Cismaplat, Cisplatyl, Lederplatin, Neoplatin, Platamine, Platinex, Platiblastin, Platinol, Platinoxan. Grades: Reagent Grade. CAS No. 15663-27-1. Pack Sizes: 250mg, 1g, 5g, 10g. US Biological Life Sciences. | Worldwide |
Cisplatin Quick inquiry Where to buy Suppliers range | Cisplatin Inhibitor. Uses: Scientific use. Product Category: T1564. CAS No. 15663-27-1. | |
CISPLATIN Quick inquiry Where to buy Suppliers range | CISPLATIN. CAS No. 15663-27-1. Categories: Cisplatin. | |
Cisplatin (cis-Dichlorodiammineplatinum(II)) Quick inquiry Where to buy Suppliers range | 100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: Cl2H6N2Pt. CAS No. 15663-27-1. Prepack ID 52453372-100mg. Molecular Weight 300.05. See USA prepack pricing. | |
Cisplatin (cis-Dichlorodiammineplatinum(II)) Quick inquiry Where to buy Suppliers range | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: Cl2H6N2Pt. CAS No. 15663-27-1. Prepack ID 52453372-1g. Molecular Weight 300.05. See USA prepack pricing. | |
Cisplatin dinitrodiammineplatinum Quick inquiry Where to buy Suppliers range | Cisplatin dinitrodiammineplatinum. CAS No. 14286-02-03. Molecular formula: Pt(NH3)2(NO2)2. Mole weight: 321.23. | |
Cisplatin impurity A Quick inquiry Where to buy Suppliers range | Cisplatin impurity A. Uses: For analytical and research use. Group: European Pharmacopoeia (Ph. Eur.); Pharmacopoeial Standards. Alternative Names: trans-Diamminedichloroplatinum, Transplatin, trans-Diamminedichloro-platinum, trans-Platinum(II) ammonium chloride, trans-Platinumdiammine dichloride, trans-Diaminedichloroplatinum, trans-Dichlorodiammineplatinum(II), trans-Dichlorodiammine platinum, trans-DDP, trans-Diamminedichloroplatinum(II), (SP-4-1)-Diamminedichloro-platinum, NSC 131558, trans-Dichlorodiamineplatinum(II). CAS No. 14913-33-8. Molecular formula: Cl2H6N2Pt. Mole weight: 300.04. Catalog: APS14913338A. SMILES: [Cl-][Pt+2]([Cl-])([NH3])[NH3]. Format: Neat. Product Type: Impurity. Shipping: Room Temperature. | |
Cisplatin impurity B Quick inquiry Where to buy Suppliers range | Cisplatin impurity B. Uses: For analytical and research use. Group: European Pharmacopoeia (Ph. Eur.); Pharmacopoeial Standards. Alternative Names: NSC 123898, Potassium amminetrichloroplatinate, Platinate(1-), amminetrichloro-, potassium (8CI), Potassium trichloroammineplatinate(II) (6CI,7CI),Platinate(1-), amminetrichloro-, potassium, (SP-4-2)- (9CI), Potassium amminetrichloroplatinate(1-) Coordination Compound. CAS No. 13820-91-2. Molecular formula: K.Cl3H3NPt. Mole weight: 357.57. Catalog: APS13820912. SMILES: [K+].[Cl-][Pt+2]([Cl-])([Cl-])[NH3]. Format: Neat. Product Type: Impurity. Shipping: Room Temperature. | |
Amifostine Quick inquiry Where to buy Suppliers range | Amifostine is a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. Uses: Radiation-protective agents. Synonyms: Ethyol; WR2721; WR 2721; WR-2721. Grades: >98%. CAS No. 20537-88-6. Molecular formula: C5H15N2O3PS. Mole weight: 214.22. | |
Amifostine Trihydrate Quick inquiry Where to buy Suppliers range | Amifostine is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin. Synonyms: Amifostine hydrate. Grades: >98%. CAS No. 112901-68-5. Molecular formula: C5H15N2O3PS.3H2O. Mole weight: 268.27. | |
Aroplatin Quick inquiry Where to buy Suppliers range | Aroplatin is a synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity. The liposomal encapsulation improves the bioavailability of NDDP and reduces its toxicity profile. CAS No. 114488-24-3. Molecular formula: C26H52N2O4Pt. Mole weight: 651.79. | |
AS101 Quick inquiry Where to buy Suppliers range | AS101 is a synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with immuno-modulating, antiviral, and hair growth-promoting activities. This agent is also a potent inducer of IL-1 and IL-6. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced alopecia. Synonyms: AS-101; IVX-Q-101; PRX-0001; PRX-0002; PRX-001; WAX-120337; IVXQ-101; AS101; IVXQ101; PRX0001; PRX0002; PRX001;WAX120337; AS 101; IVX Q 101; PRX 0001; PRX 0002; PRX 001; WAX 120337; IVXQ 101; US brand name: Ossirene; IVX-Q-101. Ammonium trichloro(dioxoethylene-O,O') tellurate. CAS No. 106566-58-9. Molecular formula: C2H4Cl3O2Te.H4N. Mole weight: 312.049. | |
ATR/CDK Inhibitor, NU6027 (2,6-diamino-4-cyclohexyl-methyloxy-5-nitroso-pyrimidine, ATR Inhibitor, NU6027, CDK2 Inhibitor) Quick inquiry Where to buy Suppliers range | A cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (Ki=2.5uM for CDK1, and Ki=1.3uM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC50=6.7uM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10uM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 220036-08-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
ATR Inhibitor IV (VE821, 3-amino-6- (4- (methylsulfonyl) phenyl) -N-phenylpyrazine-2-carboxamide, VE-821, ATM and Rad3-Related Inhibitor IV) Quick inquiry Where to buy Suppliers range | A cell-permeable phenylpyrazine derivative that acts as a potent, ATP-competitive (Ki= 13nM; IC50/[ATP] = 70nM/50uM and 128nM/100uM), ATR-selective inhibitor with much reduced or little potency against 4 related PIKKs (Ki= 2.2, 3.9, 16, and >1uM, respectively, against DNA-PK, PI 3-K-gamma, ATM, and mTOR) and 50 other kinases. Shown to selectively inhibit ATR-dependent H2AX Ser139 & Chk1 Ser345 phosphorylation (complete inhibition at 10uM in HT29 and HFL1 cultures) without affecting ATM- and DNA-PK-mediated H2AX or ATM-mediated Chk2 phosphorylation. Short-term (24h) VE-821 treatment, either alone or in synergy with Cisplatin, results in reversible cytostatic growth arrest regardless of cellular ATM-p53 pathway activity, while cytotoxicity and Cisplatin synergism in cell death induction is reported to occur only upon long-term VE-821 exposure (≥72h) in cultures with ATM-p53 pathway defects.CAS No.1232410-49-10. Group: Biochemicals. Grades: Highly Purified. CAS No. 1232410-49-10. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
ATR Kinase Inhibitor II (3-Amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)-phenyl)-N-phenylpyrazine-2-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable aminopyrazinyl-sulfone compound that acts as a potent, reversible and ATP-competitive inhibitor of ATR kinase (IC50 = 12nM; Ki=6nM) with excellent selectivity over ATM, DNA-PK (IC50 > 8uM) and in a 50-kinase panel (% inhibition at 2uM = 59, 57, 55, 52, 43 and 42 for AMPK, Lck, RIPK2, Ret, IKK-alpha and FGFR3, respectively). Shown to block pH2AX-Ser139 (IC50 = 420nM in hydroxyurea treated HT29 cells) and preferentially enhance cisplatin cytotoxicity against tumor cells over normal cells by ~7-fold at 620nM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
Bemcentinib Quick inquiry Where to buy Suppliers range | Bemcentinib is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Pharmacologic investigations revealed favorable exposure after oral administration such that R428-treated tumors displayed a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibited angiogenesis in corneal micropocket and tumor models. R428 administration reduced metastatic burden and extended survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P < 0.05) mouse models of breast cancer metastasis. Additionally, R428 synergized with cisplatin to enhance suppression of liver micrometastasis. Our results show that Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade confers therapeutic value in prolonging survival of animals bearing metastatic tumors. Synonyms: BGB324; BGB-324; BGB 324; R 428; R-428; R428; 1-(6,7-dihydro-5H-benzo[2,3]cyclohepta[2,4-d]pyridazin-3-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine. CAS No. 1037624-75-1. Molecular formula: C30H34N8. Mole weight: 506.658. | |
Carboplatin Quick inquiry Where to buy Suppliers range | Analog of Cisplatin with reduced nephrotoxicity. Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death. Group: Biochemicals. Alternative Names: (SP-4-2)-Diamimine[1, 1-cyclobutanedi (carboxylato-kO) (2-)]platinum; cis-Diammine (1, 1-cyclobutane dicarboxylato) platinum (II) ; CBDCA; JM-8; Paraplatin. Grades: Purified. CAS No. 41575-94-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
Carboplatin-d4 ((SP-4-2)-Diamimine[1,1-cyclobutane-d4-di(carboxylato-kO)(2-)]platinum,. cis-Diammine (1, 1-cyclobutane-d4-dicarboxylato)platinum (II), CBDCA-d4, JM-8-d4, Paraplatin-d4) Quick inquiry Where to buy Suppliers range | Analog of Cisplatin with reduced nephrotoxicity. Antineoplastic. Group: Biochemicals. Alternative Names: (SP-4-2)-Diamimine[1,1-cyclobutane-d4-di(carboxylato-kO)(2-)]platinum; cis-Diammine (1, 1-cyclobutane-d4-dicarboxylato)platinum (II); CBDCA-d4; JM-8-d4; Paraplatin-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
cis-Diamineplatinum(II) dichloride Quick inquiry Where to buy Suppliers range | cis-Diamineplatinum(II) dichloride. Uses: Cisplatin is a cytostatic agent and it is used to treat various cancer types, including cancer of ovary, testis, lung, head, neck, bladder, neuroblastoma, and nephroblastoma, and Hodgkin's disease and non-Hodgkin lymphoma.CDDP, also referred to as cisplatinum or cisplatin, is a yellow powder and has found widespread use a chemotherapeutic agent.Cisplatin, combined with bleomycin and vinblastine or etoposide, produces cures in most patients with metastatic testicular cancer or germ cell cancer of the ovary. Cisplatin also shows some activity against carcinomas of the head and neck, bladder, cervix, prostate, and lung. Group: Platinum series of catalysts. Alternative Names: cis-Dichlorodiammine platinum(II). Grades: Pt ≥65.0%. CAS No. 15663-27-1. Product ID: ACM15663271. Molecular formula: Pt(NH3)2Cl2. Mole weight: 300.05. Appearance: yellow crystals. Melting Point: 270 °C(lit.). | |
Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro) Quick inquiry Where to buy Suppliers range | Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro), a cyclic RGD peptide, stimulates the contraction of rat afferent arterioles and is used for targeted delivery of cisplatin. It inhibits the adhesion of mouse B16 melanoma cells to fibronectin coated wells. Synonyms: cyclo[L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-prolyl-glycyl]; c(GRGDSP). Grades: ≥90%. CAS No. 135432-37-0. Molecular formula: C22H35N9O9. Mole weight: 569.58. | |
Denibulin Quick inquiry Where to buy Suppliers range | Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy. Synonyms: MN-029; MN 029; MN029; (S)-methyl (5-((4-(2-aminopropanamido)phenyl)thio)-1H-benzo[d]imidazol-2-yl)carbamate. CAS No. 284019-34-7. Molecular formula: C18H19N5O3S. Mole weight: 385.44. | |
EBPC Quick inquiry Where to buy Suppliers range | EBPC is a potent and selective aldose reductase inhibitor. It is used to improve the cytotoxicity of anticancer reagents such as cisplatin and doxorubicin in HeLa cervical carcinoma cells via an increase in ERK activity. Synonyms: Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate; 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester; MFCD00179167; 1-benzyl-4-[ethoxy (hydroxy)methylidene]pyrrolidine-2, 3-dione. Grades: ≥99% by HPLC. CAS No. 4450-98-0. Molecular formula: C14H15NO4. Mole weight: 261.28. | |
Gap Junction Enhancer, PQ7 Quick inquiry Where to buy Suppliers range | A cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ~500nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents. Blocks T47D cell colony formation (IC50 = 100nM) and reduce the growth of T47D xenograft tumors by 100% in Nu/Nu mice. Increases caspase-3, - 8, and -9 expression by 1.6, 2.8, and 3.8-fold, respectively to induce apoptotic cell death. Can work synergistically with cisplatin to reduce or totally eliminate tumor growth. Increases the expression of connexins 26, 32, and 43 to allow more efficient trafficking of cisplatin. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N2O?, Primary Target IC50: 100nM. US Biological Life Sciences. | Worldwide |
Ginsenoside Rg5 Quick inquiry Where to buy Suppliers range | Ginsenoside Rg5 is an aromatase inhibitor from Panax ginseng leaves. Also, it ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of inflammation, oxidative stress, and apoptosis. Group: Biochemicals. Alternative Names: (3 β,12 β,20E)-12-hydroxydammara-20(22),24-dien-3-yl 2-O- β-D-glucopyranosyl- β-D-glucopyranoside. Grades: Highly Purified. CAS No. 186763-78-0. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??O??, Molecular Weight: 767. US Biological Life Sciences. | Worldwide |
Glutathione EP Impurity C Quick inquiry Where to buy Suppliers range | Oxiglutatione is a stabilized formulation of disodium glutathione disulfide (GSSG; oxidized glutathione) and cisplatin (1000:1) with potential chemoprotective and immunomodulating activities. Mimicking endogenous GSSG, Oxiglutatione acts as a competitive substrate for gamma-glutamyl-transpeptidase (GGT), which may result in the S-glutathionylation of proteins, predominantly actin, a redox stress on endoplasmic reticulum (ER), and ER stress-induced apoptosis. S-glutathionylation may be stimulated by reactive oxygen species (ROS) liberated by an oxiglutatione-induced increase in GGT activity. Oxiglutatione may also induce phosphorylation of proteins such as ERK and p38, two kinases that play critical regulatory roles in cell proliferation and apoptosis. The cisplatin component of this agent does not provide an effective therapeutic concentration of cisplatin in vivo. Synonyms: L-Glutathione Oxidised; Oxiglutatione; glutathione disulfide; GSSG; NOV-002; NOV 002; NOV002. Grades: >98%. CAS No. 27025-41-8. Molecular formula: C20H32N6O12S2. Mole weight: 612.63. | |
Golotimod TFA Quick inquiry Where to buy Suppliers range | Golotimod TFA is an immunomodulating peptide that has antimicrobial activity. Golotimod TFA inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Synonyms: SCV 07 TFA. Molecular formula: C18H20F3N3O7. Mole weight: 447.36. | |
Heptaplatin Quick inquiry Where to buy Suppliers range | Eptaplatin is a platinum-based coordination compound with anticancer activity against various cancer cell lines, including cisplatin-resistant cancer cell lines. Synonyms: Heptaplatin, Sunpla; HTP; NSC-644591, NSC 644591;NSC644591; NSC-D-644591; NSC D 644591; SKI-2053R; SKI 2053R. Grades: >98%. CAS No. 146665-77-2. Molecular formula: C11H20N2O6Pt. Mole weight: 471.36. | |
Iproplatin Quick inquiry Where to buy Suppliers range | Iproplatin is a synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione inactivation compared to cisplatin, resistance to this agent has been observed in vitro due to repair of platination damage by tumor cells. Synonyms: CHIP; Code name: JM-9; JM 9; JM9. CAS No. 62928-11-4. Molecular formula: C6H22Cl2N2O2Pt. Mole weight: 420.24. | |
KP1019 Quick inquiry Where to buy Suppliers range | KP1019, also known as FFC14A, is just the second ruthenium-based anticancer agent after NAMI-A which was developed to the stage of clinical trials. Important steps in the mode of action of KP1019 are thought to be the binding to the serum protein transferrin and the transport into the cell via the transferrin pathway. Additionally, the selective activation by reduction in the tumor might contribute to the low side effects observed in in vivo studies. Apoptosis is induced at non-toxic levels via the mitochondrial pathway. These features distinguish it from the established platinum anticancer drugs and suggest that different types of cancer might be treatable with this drug. Indeed, promising activity against certain types of tumors, which are not successfully treatable with cisplatin, and only a very low incidence of acquired resistance has been observed in in vitro and in vivo studies. Recently, a clinical phase I trial was finished in which none of the treated patients experienced serious side effects, while disease stabilization in five of six evaluable patients was achieved. Synonyms: KP1019; KP 1019; KP-1019; FFC14A; indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)]. CAS No. 124875-20-3. Molecular formula: C21H19Cl4N6Ru. Mole weight: 598.30. | |
KRX-0402 Quick inquiry Where to buy Suppliers range | KRX-0402 (O6-benzyl guanine or O6-BG) is a small molecule that was specifically designed to block the DNA repair protein, MGMT. MGMT confers resistance to certain alkylating agents, such as temozolomide and BCNU, that are commonly used to treat brain cancer, melanoma and non-Hodgkin's lymphoma. Recent research has shown that KRX-0402 can also potentiate the activity of other alkylating agents, such as cyclophosphamide, ifosphamide, cisplatinum and carboplatinum. These drugs are some of the most widely used chemotherapy drugs and are commonly used to treat breast cancer, non-small cell lung cancer and ovarian cancer. Accordingly, It is believed that KRX-0402 may have an important role in making cells more susceptible to the damaging effects of alkylating agents, and that KRX-0402 may have utility in the treatment of multiple forms of cancer. KRX-0402 is administered intravenously. To date, approximately 400 patients have received KRX-0402 in multiple clinical studies. Dose limiting toxicity for KRX-0402 in combination with chemotherapy was bone marrow suppression. KRX-0402 alone has no identified dose limiting toxicity. Two company-sponsored, Phase II clinical trials for KRX-0402 are ongoing. Uses: Enzyme inhibitors. Synonyms: KRX 0402; KRX0402; 6-O-Benzylguanine; 6-(Benzyloxy)-7H-purin-2-amine; O(6)-Benzylguanine; 2-Amino-6-(benzyloxy)purine; NSC-637037; O6-BG. CAS No. 1000874-21-4. Molecular formula: C12H11N5O. Mole weight: 241.254. | |
KX1-004 Quick inquiry Where to buy Suppliers range | KX1-004 is an Src-protein tyrosine kinase inhibitor to reduce cisplatin ototoxicity while preserving its antitumor effect. KX1-004 has been used to protect the cochlea from hazardous noise. Synonyms: KX1-004; KX 1-004; KX1 004. Grades: 0.98. CAS No. 518058-84-9. Molecular formula: C16H13FN2O2. Mole weight: 284.29. | |
KX1-141 Quick inquiry Where to buy Suppliers range | KX1-141 is an Src-protein tyrosine kinase inhibitor, which may reduce cisplatin ototoxicity while preserving its antitumor effect. Synonyms: KX-1-141; KX 1-141; 1H-Indole-2-carboxamide, 7-(3-ethoxyphenyl)-5-fluoro-N-[(3-fluorophenyl)methyl]-. Grades: 98%. CAS No. 1000706-00-2. Molecular formula: C24H20F2N2O2. Mole weight: 406.42. | |
LMK-235 Quick inquiry Where to buy Suppliers range | LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor. LMK-235 demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μM respectively). Uses: Histone deacetylase inhibitors. Synonyms: LMK-235; LMK 235; LMK235. Grades: 0.98. CAS No. 1418033-25-6. Molecular formula: C15H22N2O4. Mole weight: 294.351. | |
Mirk/Dyrk1B Inhibitor, Compound A (N- (2-Chloro-5- (3-chlorobenzylcarbamoyl) phenyl) -2-methoxy-7-oxo-7, 8-dihydropyrido[2, 3-d]pyrimidine-6-carboxamide, N- (2-Chloro-5- ( (3-chlorobenzyl) carbamoyl) phenyl) -7-hydroxy-2-methoxypyrido[2, 3-d]pyrimidine-6-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable di hydropyridopyrimidine-carboxamide compound that acts as a potent and reversible inhibitor of Mirk/Dyrk1B and Dyrk1A kinases (IC50 = 68 and 22nM). Exhibits very high selectivity for Mirk/Dyrk1B compared to Abl, Flt3, and MARK1 (64, 56 and 73% inhibition at 10uM, respectively) and a panel of 46 other kinases. Shown to induce activation of caspase-3 and sensitize tumor cells to the action of gemcitabine and cisplatin, possibly by de-stabilizing p27. Preferentially increases cycling in Mirk-elevated quiescent pancreatic cancer cells (SU86.86, Panc1, AsPc1, and SW620 at ~1uM). Also, shown to increase level of superoxides in quiescent pancreatic tumor cells (Panc1, SU86.86, and AsPc1) by blocking SOD2 and SOD3 activities. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Nedaplatin Quick inquiry Where to buy Suppliers range | Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM. Synonyms: Nedaplatin; 95734-82-0; AquplaNSC 375101Dazane;2-hydroxyacetic acid;platinum. Grades: >98%. CAS No. 95734-82-0. Molecular formula: C2H8N2O3Pt. Mole weight: 303.17. | |
NU6027 Quick inquiry Where to buy Suppliers range | NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. NU6027 attenuated G2/M arrest following DNA damage, inhibited RAD51 focus formation and increased the cytotoxicity of the major classes of DNA-damaging anticancer cytotoxic therapy but not the antimitotic, paclitaxel. In A2780 cells sensitisation to cisplatin was greatest in cells with functional p53 and mismatch repair (MMR) and sensitisation to temozolomide was greatest in p53 mutant cells with functional MMR. Importantly, NU6027 was synthetically lethal when DNA single-strand break repair is impaired either through poly(ADP-ribose) polymerase (PARP) inhibition or defects in XRCC1. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and PARP inhibitors. It provides proof of concept data for clinical development of ATR inhibitors. Synonyms: NU-6027; NU 6027; 2,6-Diamino-4-(cyclohexylmethoxy)-5-nitrosopyrimidine; 6-(Cyclohexylmethoxy)-5-nitroso-2,4-pyrimidinediamine; 4-Cyclohexylmethoxy-2,6-diamino-5-nitrosopyrimidine; 4-Cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine. Grades: ≥98%. CAS No. 220036-08-8. Molecular formula: C11H17N5O2. Mole weight: 251.29. | |
Ondansetron Hydrochloride Dihydrate Quick inquiry Where to buy Suppliers range | Ondansetron hydrochloride dihydrate is a specific and competitive antagonist of serotonin 5-HT3 receptor (Ki = 0.77 nM) with anxiolytic and neuroleptic activities. It can be used for the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, such as cisplatin. Uses: Serotonin 5-ht3 receptor antagonists. Synonyms: Zofran; GR 38032F; Ondansetron (hydrochloride dihydrate). Grades: 99.37 %. CAS No. 103639-04-9. Molecular formula: C18H19N3O.HCl.2H2O. Mole weight: 365.85. | |
Oxaliplatin EP Impurity C Quick inquiry Where to buy Suppliers range | A metabolite of Oxaliplatin, which is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Synonyms: (OC-6-33)-[(1R,2R)-cyclohexane-1,2-diamine-kN,kN'][ethanedioato(2-)-κN,κN]dihydroxyplatinum. Grades: > 95%. Molecular formula: C8H14N2O6Pt. Mole weight: 429.3. | |
Oxaliplatin EP Impurity E Quick inquiry Where to buy Suppliers range | A metabolite of Oxaliplatin, which is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Synonyms: (SP-4-2)-di-μ-oxidobis[(1R,2R)-cyclohexane-1,2-diamine-1κ2N,2κ2N']diplatinum; Diaquodiaminocyclohexaneplatinum dimer; (SP-4-2)-Di-oxobis[(1R,2R)-1,2-cyclohexanediamine-κN,κN']diplatinum(2+); Platinum(2+), bis(1,2-cyclohexanediamine-N,N')di-μ-hydroxydi-, stereoisomer; 1,2-Cyclohexanediamine, platinum complex, (1R-trans)-. Grades: ≥95%. CAS No. 108033-10-9. Molecular formula: C12H28N4O2Pt2. Mole weight: 650.54. | |
Oxaliplatin Impurity 1 Quick inquiry Where to buy Suppliers range | A metabolite of Oxaliplatin, which is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Synonyms: Dihydroxy Oxaliplatin-Pt(IV); (OC-6-33)-[(1R, 2R)-1, 2-Cyclohexanediamine-κN1, κN2][ethanedioato(2-)-κO1, κO2]dihydroxyplatinum. Grades: > 95%. CAS No. 111321-67-6. Molecular formula: C8H16N2O6Pt. Mole weight: 431.31. | |
Oxaliplatin Impurity B Quick inquiry Where to buy Suppliers range | A metabolite of Oxaliplatin, which is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Synonyms: (SP-4-2)-diaqua[(1R,2R)-cyclohexane-1,2-diamine-kN,kN']platinum. Grades: > 95%. Molecular formula: C6H18N2O2Pt. Mole weight: 345.3. | |
Pemetrexed acid oxo impurity Quick inquiry Where to buy Suppliers range | An impurity of Pemetrexed which was approved by the United States Food and Drug administration in 2004 for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin, a platinum-containing chemotherapeutic drug. Synonyms: 4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid. Grades: > 95%. CAS No. 193265-47-3. Molecular formula: C15H14N4O4. Mole weight: 314.3. | |
Pemetrexed Impurity D Quick inquiry Where to buy Suppliers range | An impurity of Pemetrexed which is used to treat mesothelioma in combination with another chemotherapy drug called cisplatin. Grades: > 95%. CAS No. 144051-68-3. Molecular formula: C25H28N6O9. Mole weight: 556.54. | |
Pemetrexed Impurity E Disodium Salt Quick inquiry Where to buy Suppliers range | An impurity of Pemetrexed, which has been approved by FDA in 2004 for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin, a platinum-containing chemotherapeutic drug. Synonyms: (2R)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid sodium. Grades: >95%. CAS No. 937370-10-0. Molecular formula: C20H19N5Na2O6. Mole weight: 471.38. | |
Pemetrexed Impurity-S Quick inquiry Where to buy Suppliers range | An impurity of Pemetrexed which is used to treat mesothelioma in combination with another chemotherapy drug called cisplatin. Grades: > 95%. Molecular formula: C20H21N5O7. Mole weight: 443.42. | |
Potassium tri chloroammineplatinate Quick inquiry Where to buy Suppliers range | Potassium tri chloroammineplatinate is the degradation product of Cisplatin (C499500), an antitumor compound which exhibits mutagenic activity. Group: Biochemicals. Alternative Names: NSC 123898; Potassium Amminetri chloroplatinate; Potassium Amminetri chloroplatinate; Magnus Red Anion Salt; Amminetrichloro-Platinate(1-) Potassium. Grades: Highly Purified. CAS No. 13820-91-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Prodigiosin, Serratia marcescens (NSC 47147, Casein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene) Quick inquiry Where to buy Suppliers range | A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50=2.0uM in A549-FKR cells) through inhibition of FADD-kinase CK1a (IC50 ~6.0uM in SW620-BGCR cells) and augments cisplatin -induced apoptosis. Blocks NF-kB activation by decreasing plkBa (by 63% at 3uM) and lkBa levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3mg/kg, i.p., o.d.). Group: Biochemicals. Grades: Highly Purified. CAS No. 82-89-3. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
RAD51 Inhibitor, B02 ((E)-3-Benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one) Quick inquiry Where to buy Suppliers range | A cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC50=27.4uM). Does not affect RecA even at much higher concentration (~250uM). Directly interacts with RAD51 (=5.6uM), and disrupts its binding to DNA and nucleoprotein filament formation. Blocks double-strand break-induced homologous recombination and enhances sensitivity of cells to Cisplatin and Mitomycin C. Diminishes co-aggregate formation between RAD51-ssDNA filament and dsDNA. RAD51-Stimulatory Compound-1, RS-1 is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
RKS-262 Quick inquiry Where to buy Suppliers range | RKS262 is a specific cyclin/CDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line assay RKS262 exhibited significant cytotoxicity in ovarian cancer cells and a variety of other cell lines exceeding effects of commercial drugs such as cisplatin, 5-FU, cyclophosphamide or sapacitabine. Various leukemia cell-lines were most sensitive while several non-small cell lung cancer cell lines and few cell lines from other tissues were relatively resistant to RKS262 treatment. Synonyms: RKS-262; RKS 262; RKS-262. CAS No. 1041469-97-9. Molecular formula: C15H14BrClN2O4S. Mole weight: 433.70. | |
Satraplatin Quick inquiry Where to buy Suppliers range | Satraplatin, also known as JM216, is a platinum compound that is currently under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy. It has not yet received approval from the U.S. Food and Drug Administration. First mentioned in the medical literature in 1993, satraplatin is the first orally active platinum-based chemotherapeutic drug; other available platinum analogues-cisplatin, carboplatin, and oxaliplatin-must be given intravenously. It is made available in the United States jointly by Spectrum Pharmaceuticals and GPC Biotech under the name SPERA (Satraplatin Expanded Rapid Access). The drug has also been used in the treatment of lung and ovarian cancers. The proposed mode of action is that the compound binds to the DNA of cancer cells rendering them incapable of dividing. Synonyms: BMS-182751; BMS 182751; BMS182751; JM 216; JM216; JM-216. CAS No. 129580-63-8. Molecular formula: C10H24Cl2N2O4Pt. Mole weight: 500.28. | |
trans-Dichlorodiamineplatinum(II); Transplatin Quick inquiry Where to buy Suppliers range | trans-Dichlorodiamineplatinum(II); Transplatin. Group: Metal & Ceramic Materials. Alternative Names: SPECTRUM1502107; PLATINOL (TN); AKOS005137969; Cisplatin,(S); DDP-H; KS-00000VH3; SR-05000001586; AC1NUSPB; 913C338; NCGC00094962-03. CAS No. 14913-33-8. Molecular formula: Cl2H6N2Pt. Mole weight: 300.046g/mol. IUPAC Name: azane;dichloroplatinum. Exact Mass: 298.956g/mol. SMILES: N.N.Cl[Pt]Cl. InChI: InChI=1S/2ClH.2H3N.Pt/h2*1H; 2*1H3; /q; ; ; ; +2/p-2. InChIKey: LXZZYRPGZAFOLE-UHFFFAOYSA-L. H-Bond Donor: 2. H-Bond Acceptor: 2. Monoisotopic Mass: 298.956g/mol. | |
Transplatin Quick inquiry Where to buy Suppliers range | The less-active isomer of the DNA damanging, platinum antitumor drug cisplatin. Transplatin is used in the treatment of a variety of solid tumors. Transplatin's anti-tumor activity can be activated by light. Synonyms: Trans-Dichlorodiamineplatinum(II); Azane; Cisplatin. CAS No. 14913-33-8. Molecular formula: Cl2H6N2Pt. Mole weight: 300.05. | |
UTL-5G Quick inquiry Where to buy Suppliers range | UTL-5G (GBL-5g) is an anti-inflammatory TNF-α inhibitor. It reduces cisplatin-induced hepatotoxicity, nephrotoxicity and bone marrow toxicity by inhibiting TNF-α and other factors. Synonyms: 3-Isoxazolecarboxamide, N-(2,4-Dichlorophenyl)-5-Methyl-. Grades: 98%. CAS No. 646530-37-2. Molecular formula: C11H8Cl2N2O2. Mole weight: 271.1. |