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| Product | Description | |
|---|---|---|
| Cisplatin | Chemotherapeutic agent for use in preventing the advancement of testicular cancer. Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links. Group: Biochemicals. Alternative Names: cis-Dichlorodiammine platinum(II); cis-Platinum(II) diammine dichloride; Cisplatin; Briplatin, Cismaplat, Cisplatyl, Lederplatin, Neoplatin, Platamine, Platinex, Platiblastin, Platinol, Platinoxan. Grades: Reagent Grade. CAS No. 15663-27-1. Pack Sizes: 250mg, 1g, 5g, 10g. US Biological Life Sciences. |  Worldwide |
| Cisplatin | Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: cis-Platinum; CDDP; cis-Diaminodichloroplatinum. CAS No. 15663-27-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-17394. |  |
| Cisplatin | Cisplatin induces cytotoxicity by interaction with DNA to form DNA adducts which activate several signal transduction pathways, including Erk, p53, p73, and MAPK, which culminates in the activation of apoptosis. It is used in several types of cancer. Uses: Antineoplastic agent. Synonyms: (SP-4-2)-diamminedichloro-platinum. Grade: >98%. CAS No. 15663-27-1. Molecular formula: Cl2H6N2Pt. Mole weight: 300.05. |  |
| Cisplatin | Cisplatin Inhibitor. Uses: Scientific use. Product Category: T1564. CAS No. 15663-27-1. |  |
| Cisplatin | Pharmaceutical Secondary Standard; Certified Reference Material. Group: Pharmacopeia & metrological institutes standards. |  |
| Cisplatin | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standardsbritish pharmacopoeiaeuropean pharmacopoeia (ph. eur.)pharmacopoeial standards. Alternative Names: Cisplatin, cis-Diamminedichloroplatinum(II). | |
| Cisplatin (cis-Dichlorodiammineplatinum(II)) | 100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: Cl2H6N2Pt. CAS No. 15663-27-1. Prepack ID 52453372-100mg. Molecular Weight 300.05. See USA prepack pricing. |  |
| Cisplatin (cis-Dichlorodiammineplatinum(II)) | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: Cl2H6N2Pt. CAS No. 15663-27-1. Prepack ID 52453372-1g. Molecular Weight 300.05. See USA prepack pricing. | |
| 3-Buten-1-ol | An impurity of Pemetrexed, which is used for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin, a platinum-containing chemotherapeutic drug. Synonyms: 1-Buten-4-ol; 1-Hydroxy-3-butene; 3-Butenol; 3-Butenyl alcohol; 4-Hydroxy-1-butene; Allylcarbinol; Homoallyl alcohol; NSC 60194; β-Vinylethanol. Grade: ≥95%. CAS No. 627-27-0. Molecular formula: C4H8O. Mole weight: 72.11. | |
| 6-Aminonicotinamide | 6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 ?M). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 329-89-5. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W010342. | |
| 84-B10 | 84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 698346-43-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-44307. | |
| alpha-Bisabolol | alpha-Bisabolol, an orally active sesquiterpene alcohol, induces cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol exerts a protective action against Cisplatin (HY-17394)-induced nephrotoxicity by mitigating inflammation and oxidative stress through the inhibition of NFκB activation. alpha-Bisabolol exhibits anti-inflammatory, analgesic, antibiotic and anticancer activities [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 515-69-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-121222. | |
| Amifostine | Amifostine is a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. Uses: Radiation-protective agents. Synonyms: Ethyol; WR2721; WR 2721; WR-2721. Grade: >98%. CAS No. 20537-88-6. Molecular formula: C5H15N2O3PS. Mole weight: 214.22. | |
| Aroplatin | Aroplatin is a synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity. The liposomal encapsulation improves the bioavailability of NDDP and reduces its toxicity profile. CAS No. 114488-24-3. Molecular formula: C26H52N2O4Pt. Mole weight: 651.79. | |
| AS101 | AS101 is a synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with immuno-modulating, antiviral, and hair growth-promoting activities. This agent is also a potent inducer of IL-1 and IL-6. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced alopecia. Synonyms: AS-101; IVX-Q-101; PRX-0001; PRX-0002; PRX-001; WAX-120337; IVXQ-101; AS101; IVXQ101; PRX0001; PRX0002; PRX001; WAX120337; AS 101; IVX Q 101; PRX 0001; PRX 0002; PRX 001; WAX 120337; IVXQ 101; US brand name: Ossirene; IVX-Q-101. Ammonium trichloro(dioxoethylene-O,O') tellurate. CAS No. 106566-58-9. Molecular formula: C2H4Cl3O2Te.H4N. Mole weight: 312.049. | |
| ATR/CDK Inhibitor, NU6027 (2,6-diamino-4-cyclohexyl-methyloxy-5-nitroso-pyrimidine, ATR Inhibitor, NU6027, CDK2 Inhibitor) | A cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (Ki=2.5uM for CDK1, and Ki=1.3uM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC50=6.7uM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10uM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 220036-08-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ATR Inhibitor IV (VE821, 3-amino-6- (4- (methylsulfonyl) phenyl) -N-phenylpyrazine-2-carboxamide, VE-821, ATM and Rad3-Related Inhibitor IV) | A cell-permeable phenylpyrazine derivative that acts as a potent, ATP-competitive (Ki= 13nM; IC50/[ATP] = 70nM/50uM and 128nM/100uM), ATR-selective inhibitor with much reduced or little potency against 4 related PIKKs (Ki= 2.2, 3.9, 16, and >1uM, respectively, against DNA-PK, PI 3-K-gamma, ATM, and mTOR) and 50 other kinases. Shown to selectively inhibit ATR-dependent H2AX Ser139 & Chk1 Ser345 phosphorylation (complete inhibition at 10uM in HT29 and HFL1 cultures) without affecting ATM- and DNA-PK-mediated H2AX or ATM-mediated Chk2 phosphorylation. Short-term (24h) VE-821 treatment, either alone or in synergy with Cisplatin, results in reversible cytostatic growth arrest regardless of cellular ATM-p53 pathway activity, while cytotoxicity and Cisplatin synergism in cell death induction is reported to occur only upon long-term VE-821 exposure (≥72h) in cultures with ATM-p53 pathway defects.CAS No.1232410-49-10. Group: Biochemicals. Grades: Highly Purified. CAS No. 1232410-49-10. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| ATR Kinase Inhibitor II (3-Amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)-phenyl)-N-phenylpyrazine-2-carboxamide) | A cell-permeable aminopyrazinyl-sulfone compound that acts as a potent, reversible and ATP-competitive inhibitor of ATR kinase (IC50 = 12nM; Ki=6nM) with excellent selectivity over ATM, DNA-PK (IC50 > 8uM) and in a 50-kinase panel (% inhibition at 2uM = 59, 57, 55, 52, 43 and 42 for AMPK, Lck, RIPK2, Ret, IKK-alpha and FGFR3, respectively). Shown to block pH2AX-Ser139 (IC50 = 420nM in hydroxyurea treated HT29 cells) and preferentially enhance cisplatin cytotoxicity against tumor cells over normal cells by ~7-fold at 620nM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| Bemcentinib | Bemcentinib is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Pharmacologic investigations revealed favorable exposure after oral administration such that R428-treated tumors displayed a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibited angiogenesis in corneal micropocket and tumor models. R428 administration reduced metastatic burden and extended survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P < 0.05) mouse models of breast cancer metastasis. Additionally, R428 synergized with cisplatin to enhance suppression of liver micrometastasis. Our results show that Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade confers therapeutic value in prolonging survival of animals bearing metast | |
| BI8622 | BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 ?M. BI8622 can decrease the protein expression levels of c-myc and glycolytic markers as well as immune modulatory markers after HUWE1 inhibition in triple-negative breast cancer (TNBC) cell lines. BI8622 significantly protects against cisplatin (HY-17394)-induced acute kidney injury (AKI). BI8622 significantly reduces the growth of multiple myeloma (MM) cell lines and induces cell cycle arrest. BI8622 can prevent HUWE1-dependent TTBK2 ubiquitination. BI8622 can be studied in research for various diseases including medulloblastoma, acute kidney injury, breast cancer and MM[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1875036-74-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120929. | |
| Brusatol | Brusatol (NSC?172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent[1]. Brusatol increases cellular apoptosis[2]. Uses: Scientific research. Group: Natural products. Alternative Names: NSC 172924. CAS No. 14907-98-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19543. | |
| Butein | Butein is a cAMP-specific PDE inhibitor with an IC 50 of 10.4 μM for PDE4 [1]. Butein is a specific protein tyrosine kinase inhibitor with IC 50 s of 16 and 65 μM for EGFR and p60 c-src in HepG2 cells [2]. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a [3]. Butein is a SIRT1 activator (STAC). Uses: Scientific research. Group: Natural products. Alternative Names: 2,3,4,4-tetrahydroxy Chalcone. CAS No. 487-52-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16558. | |
| Carboplatin | Analog of Cisplatin with reduced nephrotoxicity. Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death. Group: Biochemicals. Alternative Names: (SP-4-2)-Diamimine[1, 1-cyclobutanedi (carboxylato-kO) (2-)]platinum; cis-Diammine (1, 1-cyclobutane dicarboxylato) platinum (II) ; CBDCA; JM-8; Paraplatin. Grades: Purified. CAS No. 41575-94-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Carboplatin-d4 ((SP-4-2)-Diamimine[1,1-cyclobutane-d4-di(carboxylato-kO)(2-)]platinum,. cis-Diammine (1, 1-cyclobutane-d4-dicarboxylato)platinum (II), CBDCA-d4, JM-8-d4, Paraplatin-d4) | Analog of Cisplatin with reduced nephrotoxicity. Antineoplastic. Group: Biochemicals. Alternative Names: (SP-4-2)-Diamimine[1,1-cyclobutane-d4-di(carboxylato-kO)(2-)]platinum; cis-Diammine (1, 1-cyclobutane-d4-dicarboxylato)platinum (II); CBDCA-d4; JM-8-d4; Paraplatin-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Chlorophyll b | Chlorophyll b is an orally active tetrapyrrole derivative and pigment. Chlorophyll b can be obtained from photosynthetic organisms such as plants and algae. Chlorophyll b acts as a hydrogen donor and increases Glutathione levels. Chlorophyll b has antioxidant activity and functionally replaces chlorophyll a in photosystem II to participate in photosynthesis. Chlorophyll b reduces Cisplatin (HY-17394)-induced DNA damage, chromosome instability, and oxidative stress. Chlorophyll b is mainly used in the study of plant photosynthesis mechanism [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 519-62-0. Pack Sizes: 500 μg. Product ID: HY-W127709. | |
| cis-Diamineplatinum(II) dichloride | cis-Diamineplatinum(II) dichloride. Uses: Cisplatin is a cytostatic agent and it is used to treat various cancer types, including cancer of ovary, testis, lung, head, neck, bladder, neuroblastoma, and nephroblastoma, and hodgkin's disease and non-hodgkin lymphoma.cddp, also referred to as cisplatinum or cisplatin, is a yellow powder and has found widespread use a chemotherapeutic agent.cisplatin, combined with bleomycin and vinblastine or etoposide, produces cures in most patients with metastatic testicular cancer or germ cell cancer of the ovary. cisplatin also shows some activity against carcinomas of the head and neck, bladder, cervix, prostate, and lung. Group: Salt. Alternative Names: cis-Dichlorodiammine platinum(II). CAS No. 15663-27-1. Molecular formula: 300.05. Mole weight: Pt(NH3)2Cl2. Pt ≥65.0%. |  |
| Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro) | Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro), a cyclic RGD peptide, stimulates the contraction of rat afferent arterioles and is used for targeted delivery of cisplatin. It inhibits the adhesion of mouse B16 melanoma cells to fibronectin coated wells. Synonyms: cyclo[L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-prolyl-glycyl]; c(GRGDSP). Grade: ≥90%. CAS No. 135432-37-0. Molecular formula: C22H35N9O9. Mole weight: 569.58. | |
| D-α-Tocopherol Succinate | D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Vitamin E succinate. CAS No. 4345-3-3. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-131553. | |
| Denibulin | Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy. Synonyms: MN-029; MN 029; MN029; (S)-methyl (5-((4-(2-aminopropanamido)phenyl)thio)-1H-benzo[d]imidazol-2-yl)carbamate. Grade: 95%. CAS No. 284019-34-7. Molecular formula: C18H19N5O3S. Mole weight: 385.44. | |
| D-I03 | D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 ?M. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 ?M and 8 ?M, respectively. D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced RAD52 foci, but does not effect on RAD51 foci induced by Cisplatin[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 688342-78-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-124691. | |
| Diaquo[(1R,2R)-1,2-cyclohexanediamine]platinum Dimer Dinitrate | A metabolite of Oxaliplatin, which is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Synonyms: Platinum(2+), bis(1,2-cyclohexanediamine-N,N')di-μ-hydroxydi-, stereoisomer, dinitrate; 1,2-Cyclohexanediamine, platinum complex, trans-; Oxaliplatin Impurity 2; (SP-4-2)-Di-oxobis[(1R,2R)-1,2-cyclohexanediamine-κN,κN']diplatinum(2+) Dinitrate; (SP-4-2)-Di-oxobis[(1R-trans)-1,2-cyclohexanediamine-N,N']diplatinum(2+) Dinitrate. Grade: ≥95%. CAS No. 82398-34-3. Molecular formula: C12H30N4O2Pt2.2NO3. Mole weight: 776.56. | |
| Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate 4-methylbenzenesulfonate | An impurity of Pemetrexed, which has been approved by FDA in 2004 for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin, a platinum-containing chemotherapeutic drug. Synonyms: (S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate 4-methylbenzenesulfonate; N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-glutamic acid; 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl-L-glutamic acid diethyl ester p-toluenesulfonate salt. Grade: > 98%. CAS No. 165049-28-5. Molecular formula: C31H37N5O9S. Mole weight: 655.72. | |
| DL-threo-PDMP hydrochloride | DL-threo-PDMP hydrochloride is the hydrochloride form of DL-threo-PDMP that is a competitive glucosylceramide synthase ( GCS ) inhibitor. DL-threo-PDMP resensitizes refractory testicular germ cell tumors and epithelial ovarian cancer orthoxenografts to cisplatin in mice [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 80938-69-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116392B. | |
| EBPC | EBPC is a potent and selective aldose reductase inhibitor. It is used to improve the cytotoxicity of anticancer reagents such as cisplatin and doxorubicin in HeLa cervical carcinoma cells via an increase in ERK activity. Synonyms: Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate; 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester; MFCD00179167; 1-benzyl-4-[ethoxy(hydroxy)methylidene]pyrrolidine-2,3-dione. Grade: ≥99% by HPLC. CAS No. 4450-98-0. Molecular formula: C14H15NO4. Mole weight: 261.28. | |
| Eriodictyol 7-O-glucoside | Eriodictyol 7-O-glucoside is isolated from the herbs of Dracocephalum rupestre. It has protective effect on cisplatin-induced toxicity. Synonyms: (S)-2-(3,4-dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-2,3-dihydro-5-hydroxy-4H-1-benzopyran-4-one; eriodictyol-7-glucoside. Grade: 95%. CAS No. 38965-51-4. Molecular formula: C21H22O11. Mole weight: 450.39. | |
| Eriodictyol-7-O-glucoside | Eriodictyol-7-O-glucoside (Eriodictyol 7-O-β-D-glucoside), a flavonoid, is a potent free radical scavenger. Eriodictyol-7-O-glucoside is also an Nrf2 activator, confers protection against Cisplatin-induced toxicity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Eriodictyol 7-O-β-D-glucoside. CAS No. 38965-51-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N3847. | |
| Eurycomalactone | Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC50 value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF - κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394). Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Cryst. CAS No. 23062-24-0. Molecular formula: C19H24O6. Mole weight: 348.4. Purity: 0.98. Canonical SMILES: CC1C2C(C3C4(C(CC(=O)C3(C1C(=O)O2)C)C(=CC(=O)C4O)C)C)O. Product ID: ACM23062240-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| FiVe1 | FiVe1 is a vimentin (VIM) inhibitor. FiVe1 binds to the rod domain of VIM, causing metaphase VIM disassembly and hyperphosphorylation at Ser56, ultimately leading to mitotic catastrophe, multinucleation, and loss of stemness. FiVe1 has anticancer activity against soft tissue sarcomas. FiVe1 increases the sensitivity of ovarian cancer to Cisplatin (HY-17394). FiVe1 can be used for researches of mesenchymal cancers (including breast cancer and soft tissue sarcoma) and ovarian cancers[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 932359-76-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124757. | |
| Gap Junction Enhancer, PQ7 | A cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ~500nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents. Blocks T47D cell colony formation (IC50 = 100nM) and reduce the growth of T47D xenograft tumors by 100% in Nu/Nu mice. Increases caspase-3, - 8, and -9 expression by 1.6, 2.8, and 3.8-fold, respectively to induce apoptotic cell death. Can work synergistically with cisplatin to reduce or totally eliminate tumor growth. Increases the expression of connexins 26, 32, and 43 to allow more efficient trafficking of cisplatin. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N2O?, Primary Target IC50: 100nM. US Biological Life Sciences. | Worldwide |
| Ginsenoside Rg5 | Ginsenoside Rg5 is an aromatase inhibitor from Panax ginseng leaves. Also, it ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of inflammation, oxidative stress, and apoptosis. Group: Biochemicals. Alternative Names: (3 β,12 β,20E)-12-hydroxydammara-20(22),24-dien-3-yl 2-O- β-D-glucopyranosyl- β-D-glucopyranoside. Grades: Highly Purified. CAS No. 186763-78-0. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??O??, Molecular Weight: 767. US Biological Life Sciences. | Worldwide |
| Glutathione EP Impurity C | Oxiglutatione is a stabilized formulation of disodium glutathione disulfide (GSSG; oxidized glutathione) and cisplatin (1000:1) with potential chemoprotective and immunomodulating activities. Mimicking endogenous GSSG, Oxiglutatione acts as a competitive substrate for gamma-glutamyl-transpeptidase (GGT), which may result in the S-glutathionylation of proteins, predominantly actin, a redox stress on endoplasmic reticulum (ER), and ER stress-induced apoptosis. S-glutathionylation may be stimulated by reactive oxygen species (ROS) liberated by an oxiglutatione-induced increase in GGT activity. Oxiglutatione may also induce phosphorylation of proteins such as ERK and p38, two kinases that play critical regulatory roles in cell proliferation and apoptosis. The cisplatin component of this agent does not provide an effective therapeutic concentration of cisplatin in vivo. Synonyms: L-Glutathione Oxidised; Oxiglutatione; glutathione disulfide; GSSG; NOV-002; NOV 002; NOV002. Grade: >98%. CAS No. 27025-41-8. Molecular formula: C20H32N6O12S2. Mole weight: 612.63. | |
| Golotimod TFA | Golotimod TFA is an immunomodulating peptide that has antimicrobial activity. Golotimod TFA inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Synonyms: SCV 07 TFA. Molecular formula: C18H20F3N3O7. Mole weight: 447.36. | |
| Hederagenin | Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. CAS No. 465-99-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0256. | |
| Heptaplatin | Eptaplatin is a platinum-based coordination compound with anticancer activity against various cancer cell lines, including cisplatin-resistant cancer cell lines. Synonyms: Heptaplatin, Sunpla; HTP; NSC-644591, NSC 644591; NSC644591; NSC-D-644591; NSC D 644591; SKI-2053R; SKI 2053R. Grade: >98%. CAS No. 146665-77-2. Molecular formula: C11H20N2O6Pt. Mole weight: 471.36. | |
| HSP27 inhibitor J2 | HSP27 inhibitor J2 is an HSP27 inhibitor that can significantly induce abnormal formation of HSP27 dimer and inhibit the production of HSP27 giant polymers, thereby inhibiting the chaperone function of HSP27 and reducing its cellular protective function. It significantly enhances the anti-proliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition. Synonyms: J2; 4H-1-Benzopyran-4-one, 5-hydroxy-2-methyl-7-(2-thiiranylmethoxy)-; 5-Hydroxy-2-methyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one; 5-Hydroxy-2-methyl-7-(2-thiiranylmethoxy)-4H-chromen-4-one. Grade: ≥95%. CAS No. 2133499-85-9. Molecular formula: C13H12O4S. Mole weight: 264.30. | |
| HSP27 inhibitor J2 | HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: J2. CAS No. 2133499-85-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124653. | |
| KL1333 | KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1800405-30-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128895. | |
| KMH-233 | KMH-233, a potent, reversible and selective inhibitor of l-type amino acid transporter LAT1/SLC7A5, inhibits the uptake of LAT1 substrate, l-leucin (IC50=18 ?M) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 ?M)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1941174-13-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120139. | |
| LLL12 | LLL12 is a small molecule inhibitor of STAT3 that inhibits STAT3 phosphorylation. LLL12 enhanced the inhibitory effect of Cisplatin (HY-17394) and Paclitaxel (HY-B0015) on ovarian cancer cell formation, migration, and growth[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1260247-42-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-19536. | |
| Mirk/Dyrk1B Inhibitor, Compound A (N- (2-Chloro-5- (3-chlorobenzylcarbamoyl) phenyl) -2-methoxy-7-oxo-7, 8-dihydropyrido[2, 3-d]pyrimidine-6-carboxamide, N- (2-Chloro-5- ( (3-chlorobenzyl) carbamoyl) phenyl) -7-hydroxy-2-methoxypyrido[2, 3-d]pyrimidine-6-carboxamide) | A cell-permeable di hydropyridopyrimidine-carboxamide compound that acts as a potent and reversible inhibitor of Mirk/Dyrk1B and Dyrk1A kinases (IC50 = 68 and 22nM). Exhibits very high selectivity for Mirk/Dyrk1B compared to Abl, Flt3, and MARK1 (64, 56 and 73% inhibition at 10uM, respectively) and a panel of 46 other kinases. Shown to induce activation of caspase-3 and sensitize tumor cells to the action of gemcitabine and cisplatin, possibly by de-stabilizing p27. Preferentially increases cycling in Mirk-elevated quiescent pancreatic cancer cells (SU86.86, Panc1, AsPc1, and SW620 at ~1uM). Also, shown to increase level of superoxides in quiescent pancreatic tumor cells (Panc1, SU86.86, and AsPc1) by blocking SOD2 and SOD3 activities. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Nedaplatin | Nedaplatin (NSC 375101D) is a derivative of cisplatin and DNA damage agent. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 375101D. CAS No. 95734-82-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13700. | |
| Nrf2-IN-3 | Nrf2-IN-3 (Compound R16) is a small-molecule NRF2 inhibitor and increases reactive oxygen species (ROS) production. Nrf2-IN-3 selectively binds KEAP1 mutants and restores their NRF2-inhibitory function by repairing the disrupted KEAP1/NRF2 interactions, leading to proteasome-dependent NRF2 degradation in cells. Nrf2-IN-3 sensitizes KEAP1-mutated tumor cells to Cisplatin (HY-17394), Gefitinib (HY-50895), and KEAP1 G333C-mutated xenograft to Cisplatin [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6325-13-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149508. | |
| ODQ | ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 41443-28-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101255. | |
| Potassium tri chloroammineplatinate | Potassium tri chloroammineplatinate is the degradation product of Cisplatin (C499500), an antitumor compound which exhibits mutagenic activity. Group: Biochemicals. Alternative Names: NSC 123898; Potassium Amminetri chloroplatinate; Potassium Amminetri chloroplatinate; Magnus Red Anion Salt; Amminetrichloro-Platinate(1-) Potassium. Grades: Highly Purified. CAS No. 13820-91-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Prodigiosin, Serratia marcescens (NSC 47147, Casein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene) | A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50=2.0uM in A549-FKR cells) through inhibition of FADD-kinase CK1a (IC50 ~6.0uM in SW620-BGCR cells) and augments cisplatin -induced apoptosis. Blocks NF-kB activation by decreasing plkBa (by 63% at 3uM) and lkBa levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3mg/kg, i.p., o.d.). Group: Biochemicals. Grades: Highly Purified. CAS No. 82-89-3. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
| PROTAC HK2 Degrader-1 | PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3033812-84-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155008. | |
| RAD51 Inhibitor, B02 ((E)-3-Benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one) | A cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC50=27.4uM). Does not affect RecA even at much higher concentration (~250uM). Directly interacts with RAD51 (=5.6uM), and disrupts its binding to DNA and nucleoprotein filament formation. Blocks double-strand break-induced homologous recombination and enhances sensitivity of cells to Cisplatin and Mitomycin C. Diminishes co-aggregate formation between RAD51-ssDNA filament and dsDNA. RAD51-Stimulatory Compound-1, RS-1 is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Sesame Oil | Sesame Oil is a vegetable oil. Sesame Oil can be extracted from the seeds of Sesamum indicum L. Sesame Oil decreases NF-?B, aspartate aminotransferase, alanine aminotransferase, IL-1?, IL-4 and nitric oxide. Sesame Oil has antitumor activity against malignant melanoma. Sesame Oil has protective effects against liver damage caused by various agents such as Cisplatin (HY-17394) and Acetaminophen (HY-66005). Sesame Oil shows antinociceptive and anti-inflammatory activities[1][2][3][4][5][6][7][8]. Uses: Scientific research. Group: Signaling pathways. CAS No. 8008-74-0. Pack Sizes: 50 mL; 100 mL. Product ID: HY-154629. | |
| trans-Dichlorodiamineplatinum(II); Transplatin | trans-Dichlorodiamineplatinum(II); Transplatin. Group: Electrolytes. Alternative Names: SPECTRUM1502107; PLATINOL (TN); AKOS005137969; Cisplatin,(S); DDP-H; KS-00000VH3; SR-05000001586; AC1NUSPB; 913C338; NCGC00094962-03. CAS No. 14913-33-8. Product ID: azane; dichloroplatinum. Molecular formula: 300.046g/mol. Mole weight: Cl2H6N2Pt. N.N.Cl[Pt]Cl. InChI=1S/2ClH.2H3N.Pt/h2*1H; 2*1H3; /q; ; ; ; +2/p-2. LXZZYRPGZAFOLE-UHFFFAOYSA-L. | |
| Transplatin | The less-active isomer of the DNA damanging, platinum antitumor drug cisplatin. Transplatin is used in the treatment of a variety of solid tumors. Transplatin's anti-tumor activity can be activated by light. Synonyms: Trans-Dichlorodiamineplatinum(II); Azane; Cisplatin. CAS No. 14913-33-8. Molecular formula: Cl2H6N2Pt. Mole weight: 300.05. | |
| XI-011 HCl | XI-011 (NSC146109), a small-molecule inhibitor of MDMX, showed robust anti-proliferation activity against several cervical cancer cell lines. XI-011 promoted apoptosis of cervical cancer cells via stabilizing p53 and activating its transcription activity. Moreover, XI-011 inhibited the growth of xenograft tumor in HeLa tumor-bearing mice, as well as enhanced the cytotoxic activity of cisplatin both in vitro and in vivo. Uses: Designed for use in research and industrial production. Additional or Alternative Names: XI-011 HCl; XI-011 hydrochloride; XI-011; XI011; XI011; NSC 146109 HCl; NSC146109; NSC146109. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 59474-01-0. Molecular formula: C17H17ClN2S. Mole weight: 316.85. Purity: >98%. IUPACName: Carbamimidothioic acid, (10-methyl-9-anthracenyl)methyl ester, monohydrochloride. Canonical SMILES: NC(SCC1=C2C=CC=CC2=C(C)C3=CC=CC=C13)=N.[H]Cl. Product ID: ACM59474010-1. Alfa Chemistry ISO 9001:2015 Certified. | |
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