Cyclic Nucleotide Phosphodiesterase Suppliers USA
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Product | Description | |
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2-AEA-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 2-AEA-cAMP-Agarose is the cAMP immobilized on agarose by an aminoethylamino spacer, which can be used in affinity chromatography of different cyclic nucleotide-responsive proteins such as protein kinases and phosphodiesterases. Synonyms: 2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphate, immobilized on agarose. | |
2'-AEC-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 2'-AEC-cAMP-Agarose is the protein kinase A activator cAMP immobilized on agarose by an aminoethylcarbamoyl spacer, wihch can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphate, immobilized on agarose gel. | |
2'-AEC-cGMP-Agarose Quick inquiry Where to buy Suppliers range | 2'-AEC-cGMP-Agarose is the protein kinase G activator cGMP immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
2-AHA-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 2-AHA-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminohexylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
2'-AHC-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 2'-AHC-cAMP-Agarose is the protein kinase A activator cAMP immobilized on agarose by an aminohexylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
2'-AHC-cGMP-Agarose Quick inquiry Where to buy Suppliers range | 2'-AHC-cGMP-Agarose is the protein kinase G activator cGMP immobilized on agarose by an aminohexylcarbamoyl spacer which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
2-AH-cGMP-Agarose Quick inquiry Where to buy Suppliers range | 2-AH-cGMP-Agarose is the second messenger cGMP immobilized on agarose by an aminohexyl spacer which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: N2- (6- Aminohexyl)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
2'- (N-Methylanthraniloyl) guanosine 3',5'-Cyclicmonophosphate, Sodium Salt (MANT-cGMP) Quick inquiry Where to buy Suppliers range | A blue fluorescent derivative of cGMP is a useful substrate the assay of cyclic nucleotide phosphdiesterase. Also inhibits calmodulin-dependent activation of cyclic nucleotide phosphodiesterase by peptide segments of HIV envelope glycoproteins has been monitored using MANT-cGMP.Fluorescence: max. Abs. 359nm; max. Em. 448nm; e x 10-3: 5.2. Group: Biochemicals. Alternative Names: Cyclic 3,5-(hydrogen phosphate) 2-[2-(methylamino)benzoate] Guanosine Monosodium Salt; MANT-cGMP. Grades: Highly Purified. CAS No. 221905-46-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
5,6-DCl-cBIMP Quick inquiry Where to buy Suppliers range | 5,6-DCl-cBIMP is a potent activator of protein kinase A, acting on both type I and II. It can be subsequently metabolized by cyclic nucleotide-dependent phosphodiesterases. Synonyms: 5, 6- Dichlorobenzimidazole riboside- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 129693-10-3. Molecular formula: C12H10Cl2N2O6P · Na. Mole weight: 403.1. | |
6-AE-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 6-AE-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminoethyl spacer which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. | |
6-AH-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 6-AH-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminohexyl spacer which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. | |
8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate - DY-480XL Quick inquiry Where to buy Suppliers range | DY-480XL, a biomedicine product specialized in biochemical studies, offers an intricate solution to understanding the dynamics of enzymatic interactions and signaling pathways. As a fluorescent analog of 2',5'-ADP, this product boasts the capability to study complex enzyme activities such as adenylate cyclase and cyclic nucleotide phosphodiesterase. Furthermore, it can delve into the intricate signaling pathways activated by extracellular receptors, which induce G protein-coupled pathways. The product's versatility renders it invaluable in the oncology research sphere, with its potential applications ranging from breast, ovarian to colon cancer. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate, labeled with DY 480XL, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C42H57N9O16P2S (free acid). Mole weight: 1037.97 (free acid). | |
8-AEA-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 8-AEA-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminoethylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphate, immobilized on agarose gel. | |
8-AET-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 8-AET-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminoethylthio spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 8- (2- Aminoethylthio)adenosine- 3', 5'- cyclic monophosphate, immobilized on agarose gel. | |
8-AET-cGMP-Agarose Quick inquiry Where to buy Suppliers range | 8-AET-cGMP-Agarose is the second messenger cGMP immobilized on agarose by an aminoethylthio spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 8- (2- Aminoethylthio)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
8-AHA-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 8-AHA-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminohexylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
8-CPT-6-Phe-cAMP Quick inquiry Where to buy Suppliers range | 8-CPT-6-Phe-cAMP is a selective activator of protein kinase A (cAMP agonist). It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Grades: ≥ 98% by HPLC. CAS No. 72549-36-1. Molecular formula: C22H18ClN5O6PS·Na. Mole weight: 569.9. | |
8-OH-cAMP Quick inquiry Where to buy Suppliers range | 8-OH-cAMP is a polar analogue of cAMP used for the study of extracellular cAMP receptors. When applied by patch clamp techniques, 8-OH-cAMP remains trapped inside the cell. It exhibits a resistant effect of mammalian cyclic nucleotide-dependent phosphodiesterases. Synonyms: 8- Hydroxyadenosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 31356-95-3. Molecular formula: C10H11N5O7P · Na. Mole weight: 367.2. | |
8-pCPT-PET-cGMP Quick inquiry Where to buy Suppliers range | 8-pCPT-PET-cGMP is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to 8-Br-PET-cGMP, 8-pCPT-PET-cGMP is much more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. Molecular formula: C24H18ClN5O7PS · Na. Mole weight: 609.9. | |
Adenosine 3,5-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt (8-CPT-cAMP, Na) Quick inquiry Where to buy Suppliers range | Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC50=900nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC50=25uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 93882-12-3. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?PS · Na. US Biological Life Sciences. | Worldwide |
Adenosine 3,5-cyclic Monophosphate, 8-Bromo-, Sodium Salt (8-Bromo-cAMP, Na) Quick inquiry Where to buy Suppliers range | Cell-permeable cAMP analog that has greater resistance to phosphodiesterases than cAMP. Preferentially activates protein kinase A (PKA). Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Group: Biochemicals. Grades: Highly Purified. CAS No. 76939-46-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Adenosine 3,5-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt (6-Bnz-cAMP, Na) Quick inquiry Where to buy Suppliers range | A potent cell-permeable activator of cAMP-dependent protein kinase (PKA). Activates both type 1 and type 2 PKA and binds to the cAMP binding site 2 on the regulatory subunit of PKA. It is only slowly metabolized by cyclic nucleotide-dependent phosphodiesterases. Due to its considerably increased lipophilicity, it has sufficient membrane permeability for many biological systems. Group: Biochemicals. Grades: Highly Purified. CAS No. 30275-80-0. Pack Sizes: 10umol. US Biological Life Sciences. | Worldwide |
AICAR 3,5-Cyclic Phosphate Quick inquiry Where to buy Suppliers range | A cyclic nucleotides with protein kinase and phosphodiesterase activity. Group: Biochemicals. Alternative Names: 5-Aminoimidazole-4-carboxamide-1- β-D-ribofuranosyl 3:5-cyclic-monophosphate;5-Amino-1-(3,5-O-phosphinico- β-D-ribofuranosyl)-1H-imidazole-4-carboxamide; NSC 371796. Grades: Highly Purified. CAS No. 35908-14-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
AICAR 3',5'-Cyclic Phosphate Quick inquiry Where to buy Suppliers range | A cyclic nucleotide with protein kinase and phosphodiesterase activity. Synonyms: 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 3':5'-cyclic-monophosphate;5-Amino-1-(3,5-O-phosphinico-β-D-ribofuranosyl)-1H-imidazole-4-carboxamide; NSC 371796. Grades: 94%. CAS No. 35908-14-6. Molecular formula: C9H13N4O7P. Mole weight: 320.2. | |
Caffeidine Quick inquiry Where to buy Suppliers range | Caffeidine is an impurity of Caffeine (C080100), a xanthine alkaloid that acts as a stimulant drug and a reversible acetylcholinesterase inhibitor. Caffeidine have also shown inhibitory activity towards cyclic nucleotide phosphodiesterases. Group: Biochemicals. Alternative Names: N,1-Dimethyl-4-(methylamino)imidazole-5-carboxamide; EP Impurity E. Grades: Highly Purified. CAS No. 20041-90-1. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
Caffeine Impurity E Quick inquiry Where to buy Suppliers range | Caffeidine is an impurity of Caffeine (C080100), a xanthine alkaloid that acts as a stimulant drug and a reversible acetylcholinesterase inhibitor. Caffeidine have also shown inhibitory activity towards cyclic nucleotide phosphodiesterases. Synonyms: Caffeidine; 1H-Imidazole-5-carboxamide, N,?1-dimethyl-4-(methylamino)?-, hydrochloride. Grades: > 95%. CAS No. 20041-90-1. Molecular formula: C7H12N4O. Mole weight: 168.2. | |
CHF-6001 Quick inquiry Where to buy Suppliers range | This active molecular is a Type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor originated by Chiesi Farmaceutici with IC50 value of 0.026 ± 0.006 nM. CHF6001 inhibited PDE4 isoforms A to D with equal potency, showed an elevated ratio of high-affinity rolipram binding site versus low-affinity rolipram binding site and displayed >20,000-fold selectivity versus PDE4 compared with a panel of PDEs. In May 2016, Chiesi completed a phase I trial in Chronic Obstructive Pulmonary Disease (In volunteers) in United Kingdom (Inhalation). In Oct 2016, Phase-II clinical trials in Chronic obstructive pulmonary disease (Adjunctive treatment) in Hungary (Inhalation) was on-going. Uses: Allergic asthma; chronic obstructive pulmonary disease. Synonyms: CHF-6001; CHF 6001; CHF6001. UNII-0984EU6E2F; 0984EU6E2F; CHEMBL3113974; SCHEMBL12096092; CHF6001; VCFBPAOSTLMYIV-SANMLTNESA-N;[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl] 3-(cyclopropylmethoxy)-4-(methanesulfonamido)benzoate. Grades: 98%. CAS No. 1239278-59-1. Molecular formula: C30H30Cl2F2N2O8S. Mole weight: 687.53. | |
Cilostazol Quick inquiry Where to buy Suppliers range | Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake. Uses: Bronchodilator agents. Synonyms: AT2266; CI919; Pd107779; NSC629661; AT 2266; CI 919; Pd 107779; NSC 629661; AT-2266; CI-919; Pd-107779; NSC-629661. Grades: >98%. CAS No. 73963-72-1. Molecular formula: C20H27N5O2. Mole weight: 369.46. | |
CP-220629 Quick inquiry Where to buy Suppliers range | CP-220629, a Pyrazolopyridin derivative, has been found to be a Type 4 cyclic nucleotide phosphodiesterase inhibitor that was once studied as an anti-inflammatory as well as antiasthmatic agent. Synonyms: UNII-BAV9N49AFE; CP-220629; CP 220629; CP220629; BAV9N49AFE; SCHEMBL84865; CHEMBL75819; 1-cyclopentyl-3-ethyl-6-(2-methylphenyl)-4,5-dihydropyrazolo[3,4-c]pyridin-7-one. Grades: 98%. CAS No. 162141-96-0. Molecular formula: C20H25N3O. Mole weight: 323.44. | |
Etofylline Quick inquiry Where to buy Suppliers range | An inhibitor of 3,5-Cyclic Nucleotide Phosphodiesterase. Therapeutically, this compound has diuretic, muscle relaxant, bronchial dilation and CNS stimulant activities. Group: Biochemicals. Alternative Names: 7- (2-Hydroxyethyl) theophylline; 3,7-Dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-1H-purine-2,6-dione; 7-(2-Hydroxyethyl)-1,3-dimethylxanthine; 7-Theophyllineethanol; Aethophyllinum; Ascorphylline; Bio-phylline; Cordalin; Corophyllin-N; Dilaphyllin; Etophyllin; Etophylline; Frekaphyllin; hydroxyethyl theophyl line; KT 200G; NSC 113373; Oxphylline; Oxyethophylline; Oxyethyltheophylline; Oxyphyllin; Oxyphylline; Oxytheonyl; Phyllocormin N; Soluphylline. Grades: Highly Purified. CAS No. 519-37-9. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
Etofylline Quick inquiry Where to buy Suppliers range | β-hydroxyethyltheophylline is an inhibitor of 3',5'-Cyclic Nucleotide Phosphodiesterase. Uses: An inhibitor of 3',5'-cyclic nucleotide phosphodiesterase. Synonyms: BRN 0251760; BRN-0251760; BRN0251760; 7-(2-Hydroxyethyl)theophylline;β-hydroxyethyltheophylline. Grades: ≥95%. CAS No. 519-37-9. Molecular formula: C9H12N4O3. Mole weight: 224.21. | |
Filaminast Quick inquiry Where to buy Suppliers range | Filaminast is a Type 4 cyclic nucleotide phosphodiesterase inhibitor. It is an analog of rolipram which served as a prototype molecule for several development efforts. In Oct 1999, phase II clinical trials for Asthma in European Union was discontinued. Uses: Asthma. Synonyms: UNII-CDD69JC61J; Way-pda-641; WAY-PDA 641; WAY-PDA-641; CDD69JC61J; SCHEMBL73843; 1-(3-(Cyclopentyloxy)-4-methoxyphenyl)ethanone-(E)-O-(aminocarbonyl)oxime. Grades: 98%. CAS No. 141184-34-1. Molecular formula: C15H20N2O4. Mole weight: 292.33. | |
FR-229934 Quick inquiry Where to buy Suppliers range | FR-229934 is a Type 5 cyclic nucleotide phosphodiesterase inhibitor. In Feb 2008, preclinical for Erectile dysfunction in Japan was discontinued. Uses: Erectile dysfunction. Synonyms: FR-229934; FR229934; FR 229934. 1-((3,4-dichlorophenyl)methyl)-2-methyl-N-(pentylsulfonyl)-1H-Benzimidazole-6-carboxamide. Grades: 98%. CAS No. 799841-02-4. Molecular formula: C21H23Cl2N3O3S. Mole weight: 468.40. | |
GSK-356278 Quick inquiry Where to buy Suppliers range | GSK-356278 is a selective Type 4 cyclic nucleotide phosphodiesterase inhibitor. It shows anxiolytic and cognition-enhancing effects and it has the ability to elevate cAMP in various cell types of the central nervous system. No development was reported for phase-I development in Major depressive disorder and Huntington's-disease. Uses: Huntington's disease; major depressive disorder. Synonyms: GSK-356278; GSK356278; GSK 356278; 5-(5-((2,4-dimethyl-5-thiazolyl)methyl)-1,3,4-oxadiazol-2-yl)-1-ethyl-n-(tetrahydro-2H-pyran-4-yl)-1H-Pyrazolo(3,4-b)pyridin-4-amine. Grades: 98%. CAS No. 720704-34-7. Molecular formula: C21H25N7O2S. Mole weight: 439.54. | |
IBMX (3-Isobutyl-1-methylxanthine) Quick inquiry Where to buy Suppliers range | 3-isobutyl-1-methylxanthine (IBMX) is a nonselective inhibitor of cAMP and cGMP phosphodiesterases (PDEs). Research studies show that IBMX inhibits many members of the PDE family, with the exceptions of PDE8A, PDE8B, and PDE9 (1-4). Treatment of cells with IBMX promotes accumulation of cAMP and cGMP, which leads to activation of cyclic- nucleotide- regulated protein kinases (5,6). Additional research indicates that IBMX can promote neuronal progenitor cell maturation in vitro (7). Group: Biochemicals. Grades: Highly Purified. CAS No. 28822-58-4. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
Ibudilast Quick inquiry Where to buy Suppliers range | Ibudilast is a nonselective inhibitor of cyclic nucleotide phosphodiesterase (PDE) which has been marketed for treating asthma. It crosses the blood-brain barrier, is well tolerated, is active on oral administration, reduces glial activation and attenuates pain symptoms in diverse rat models of neuropathic pain. In addition, it enhances acute morphine analgesia and attenuates morphine tolerance and withdrawal. Thus ibudilast may improve opioid efficacy and is a promising therapeutic candidate for neuropathic pain. Synonyms: MN-166, MN166, MN 166, AV-411, AV 411, AV411, KC404; KC-404; KC 404; Ibudilast. Grades: >98%. CAS No. 50847-11-5. Molecular formula: C14H18N2O. Mole weight: 230.31. | |
K 259-2 Quick inquiry Where to buy Suppliers range | K-259-2, a new inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, was isolated from the cultured broth of Micromonospora olivasterospora K-259. IC50 values for the effect of K-259-2 against Ca2+ and calmodulin-stimulated activity of the enzyme preparations from bovine brain and heart were 6.6 and 2.9 microM, respectively. Synonyms: K-259-2; 1,6,8-Trihydroxy-3-[(Z)-2-ethyl-2-butenyl]-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid. CAS No. 102819-46-5. Molecular formula: C21H18O7. Mole weight: 382.36. | |
KS-501 Quick inquiry Where to buy Suppliers range | It is produced by the strain of Sporothrix sp. KAC-1989. KS-501 inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 1.8 μmol/L. Synonyms: KS 501; 3-Heptyl-5-hydroxyphenyl 2-heptyl-6-(hexofuranosyloxy)-4-hydroxybenzoate. CAS No. 120634-86-8. Molecular formula: C33H48O10. Mole weight: 604.73. | |
KS 502 Quick inquiry Where to buy Suppliers range | It is produced by the strain of Sporothrix sp. KAC-1989. KS 502 inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 4.4 μmol/L. Synonyms: Benzoic acid, 2-(beta-D-galactofuranosyloxy)-6-heptyl-4-hydroxy-, 4-carboxy-3-heptyl-5-hydroxyphenyl ester. Grades: >98%. CAS No. 120634-85-7. Molecular formula: C34H48O12. Mole weight: 648.74. | |
KS 504a Quick inquiry Where to buy Suppliers range | It is produced by the strain of Mollisia ventosa KAC-1148. KS 504a inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 122 μmol/L. Synonyms: KS-504a; KS-504b; BRN 4354490; 1-Oxaspiro(2.4)heptan-5-ol, 2,4,4,6,6-pentachloro-7-(dichloromethylene)-. CAS No. 122022-77-9. Molecular formula: C7H3Cl7O2. Mole weight: 367.27. | |
KS-504d Quick inquiry Where to buy Suppliers range | It is produced by the strain of Mollisia ventosa KAC-1148. KS-504d inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of >500 μmol/L. Synonyms: KS 504d; BRN 4322179; (+)-1-(Dichloromethyl)-5-(dichloromethylene)-2,2,4,4-tetrachloro-1,3-cyclopentanediol. CAS No. 122005-23-6. Molecular formula: C7H4Cl8O2. Mole weight: 403.73. | |
KS-504e Quick inquiry Where to buy Suppliers range | It is produced by the strain of Mollisia ventosa KAC-1148. KS-504e inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 139 μmol/L. Synonyms: KS 504e; BRN 4321107; (+)-4-Hydroxy-3,3,5,5-tetrachloro-2-(trichloromethyl)-1-cyclopentene-1-carboxaldehyde; 1-Cyclopentene-1-carboxaldehyde, 3,3,5,5-tetrachloro-4-hydroxy-2-(trichloromethyl)-, (+)-. CAS No. 122006-32-0. Molecular formula: C7H3Cl7O2. Mole weight: 367.27. | |
L-869298 Quick inquiry Where to buy Suppliers range | L-869298 is a high potent and selective PDE4 inhibitor, acts as a Type 4 cyclic nucleotide phosphodiesterase inhibitor. Uses: Type 4 cyclic nucleotide phosphodiesterase inhibitor. Synonyms: L-869298; L-869298; L-869298; (S)-L-869298. 2-Thiazolemethanol, 5-((1S)-1-(3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl)-2-(1-oxido-3-pyridinyl)ethyl)-alpha,alpha-bis(trifluoromethyl)-. Grades: ≥98%. CAS No. 362718-73-8. Molecular formula: C23H18F8N2O4S. Mole weight: 570.45. | |
Reticulol Quick inquiry Where to buy Suppliers range | An isocoumarin metabolite produced by selected species of streptomyces. It is a potent inhibitor of cyclic nucleotide phosphodiesterase. It also causes dose-dependent inhibition of lung metastasis in the B16F10 melanoma model. Synonyms: 6,8-Dihydroxy-7-methoxy-3-methylisocoumarin; 6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one; K 251-1; NSC 294978. Grades: >95% by HPLC. CAS No. 26246-41-3. Molecular formula: C11H10O5. Mole weight: 222.19. | |
Reticulol (6,8-Dihydroxy-7-methoxy-3-methylisocoumarin) Quick inquiry Where to buy Suppliers range | Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol has also been demonstrated to cause a dose dependent inhibition of lung metastasis in the B16F10 melanoma model. Group: Biochemicals. Alternative Names: 6,8-Dihydroxy-7-methoxy-3-methylisocoumarin. Grades: Highly Purified. CAS No. 26246-41-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Ro 20-1724 Quick inquiry Where to buy Suppliers range | Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. Synonyms: Ro20-1724; Ro 20-1724; Ro-20-1724. 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone; 4-[(3-Butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone; 4-(3-Butoxy-4-methoxy benzyl)-2-imidazolidinone; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidone; DL-4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Roche 20-1724. Grades: ≥99% by HPLC. CAS No. 29925-17-5. Molecular formula: C15H22N2O3. Mole weight: 278.35. | |
Ronomilast Quick inquiry Where to buy Suppliers range | Ronomilast is type 4 cyclic nucleotide phosphodiesterase inhibitor for the treatment of chronic obstructive pulmonary disease (COPD). Uses: Type 4 cyclic nucleotide phosphodiesterase inhibitor. Synonyms: AWD 12353; AWD12353; AWD-12353; ELB353; ELB-353; ELB 353; Elbimilast; Ronomilast.N-(3,5-dichloropyridin-4-yl)-2-(1-(4-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-oxoacetamide. Grades: ≥98%. CAS No. 418794-42-0. Molecular formula: C21H13Cl2FN4O2. Mole weight: 443.25. | |
Rp-2'-AEC-cAMPS-Agarose Quick inquiry Where to buy Suppliers range | Rp-2'-AEC-cAMPS-Agarose is the protein kinase A inhibitor Rp-cAMPS immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, immobilized on agarose gel. | |
Rp-2'-AHC-cAMPS-Agarose Quick inquiry Where to buy Suppliers range | Rp-2'-AHC-cAMPS-Agarose is the PDE-resistant protein kinase A inhibitor Rp-cAMPS immobilized on agarose by an aminohexylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer; immobilized on agarose gel. | |
Rp-2'-AHC-cGMPS-Agarose Quick inquiry Where to buy Suppliers range | Rp-2'-AHC-cGMPS-Agarose is the PDE-resistant PKG inhibitor Rp-cGMPS immobilized on agarose by an aminohexylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer; immobilized on agarose gel. | |
Rp-8-AEA-cAMPS-Agarose Quick inquiry Where to buy Suppliers range | Rp-8-AEA-cAMPS-Agarose is the metabolically stable protein kinase A inhibitor Rp-cAMPS immobilized on agarose by an aminoethylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinase A (presumably as its holoenzyme), phosphodiesterases and others. Synonyms: 8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, immobilized on agarose gel. | |
Rp-8-AET-cGMPS-Agarose Quick inquiry Where to buy Suppliers range | Rp-8-AET-cGMPS-Agarose is the metabolically stable protein kinase G inhibitor Rp-cGMPS immobilized on agarose by an aminoethylthio spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 8- (2- Aminoethylthio)guanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer; immobilized on agarose gel. | |
Rp-8-AHA-cAMPS-Agarose Quick inquiry Where to buy Suppliers range | Rp-8-AHA-cAMPS-Agarose is the metabolically stable protein kinase A inhibitor Rp-cAMPS immobilized on agarose by an aminohexylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinase A (presumably as its holoenzyme), phosphodiesterases and others. Synonyms: 8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer; immobilized on agarose gel. | |
Rp-8-Br-cAMPS Quick inquiry Where to buy Suppliers range | Rp-8-Br-cAMPS is an analogue of the cAMP with a preference for type I of protein kinase A. Compared to Rp-cAMPS, it has more lipophilic and membrane-permeant properties. Rp-8-Br-cAMPS effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Synonyms: 8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 129735-00-8. Molecular formula: C10H10BrN5O5PS · Na. Mole weight: 446.2. | |
Rp-8-Br-cGMPS Quick inquiry Where to buy Suppliers range | Rp-8-Br-cGMPS is an inhibitor of protein kinase G I α and I ß. It effects against mammalian cyclic nucleotide- dependent phosphodiesterases. Compared to cGMP or Rp-cGMPS, it has more lipophilic and membrane-permeant properties. Synonyms: 8- Bromoguanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 150418-07-8. Molecular formula: C10H10BrN5O6PS · Na. Mole weight: 462.2. | |
Rp-8-Br-PET-cGMPS Quick inquiry Where to buy Suppliers range | Rp-8-Br-PET-cGMPS is a selective inhibitor of cGMP-dependent protein kinase I a and I β and of retinal cGMP-gated ion channels. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Rp-8-pCPT-cGMPS, it is much more lipophilic and membrane-permeant. Synonyms: 8- Bromo- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 172806-20-1. Molecular formula: C18H14BrN5O6PS · Na. Mole weight: 562.3. | |
Rp-8-Cl-cAMPS Quick inquiry Where to buy Suppliers range | Rp-8-Cl-cAMPS is a selective and competitive inhibitor of protein kinase A (cAMP antagonist) preferring type I of protein kinase A. It inhibits mammalian cyclic nucleotide-dependent phosphodiesterases. Synonyms: 8- Chloroadenosine- 3', 5'- monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 142754-27-6. Molecular formula: C10H10ClN5O5PS · Na. Mole weight: 401.7. | |
Rp-8-CPT-cAMPS Quick inquiry Where to buy Suppliers range | Rp-8-CPT-cAMPS is an analog of Rp-cAMPS and a competitive inhibitor of protein kinase A type I and II (cAMP antagonist). It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Rp-8-Br-cAMPS, it is more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 129735-01-9. Molecular formula: C16H14ClN5O5PS2 · Na. Mole weight: 509.8. | |
Rp-8-OH-cAMPS Quick inquiry Where to buy Suppliers range | Rp-8-OH-cAMPS is a polar analogue of Rp-cAMPS, the protein kinase A inhibitor, used for the study of extracellular cAMP receptors. It inhibits mammalian cyclic nucleotide-dependent phosphodiesterases. Synonyms: 8- Hydroxyadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 475084-30-1. Molecular formula: C10H11N5O6PS · Na. Mole weight: 383.3. | |
Rp-8-pCPT-cGMPS Quick inquiry Where to buy Suppliers range | Rp-8-pCPT-cGMPS is a selective inhibitor of protein kinase G I a, I ß and especially of type II, which stimulates retinal cGMP channels and discriminates between kinase and channel effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Rp-cGMPS or Rp-8-Br-cGMPS, it exhibits more lipophilic and membrane-permeant properties. Synonyms: 8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 153660-04-9. Molecular formula: C16H14ClN5O6PS2 · Na. Mole weight: 525.9. | |
Rp-8-pCPT-PET-cGMPS Quick inquiry Where to buy Suppliers range | Rp-8-pCPT-PET-cGMPS is an inhibitor of protein kinase G and probably of retinal cGMP-gated ion channels. It has a resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Synonyms: 8- (4- Chlorophenylthio)-β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 1262749-62-1. Molecular formula: C24H18ClN5O6PS2 · Na. Mole weight: 626. | |
Rp-8-PIP-cAMPS Quick inquiry Where to buy Suppliers range | Rp-8-PIP-cAMPS is a selective analogue of Rp-cAMPS, the protein kinase A inhibitor, preferring site B of cAK type II. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Rp-cAMPS, it has more lipophilic and membrane-permeant properties. Synonyms: 8- Piperidinoadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 156816-36-3. Molecular formula: C15H20N6O5PS · Na. Mole weight: 450.4. | |
Rp-cAMPS, sodium salt Quick inquiry Where to buy Suppliers range | Rp-cAMPS is a competitive inhibitor of protein kinase A type I and II (cAMP antagonist), which has a higher affinity for type II of protein kinase A. It exhibits a resistant effect of mammalian cyclic nucleotide-dependent phosphodiesterases. Uses: Protein kinase inhibitors. Synonyms: Adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 73208-40-9. Molecular formula: C10H11N5O5PS · Na. Mole weight: 367.3. | |
Rp-cAMPS, triethyl ammonium salt Quick inquiry Where to buy Suppliers range | Rp-cAMPS is a competitive inhibitor of protein kinase A type I and II, the cAMP antagonist, which has high selectivity of type II of protein kinase A. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Uses: Protein kinase inhibitors. Synonyms: Adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, triethyl ammonium salt. Grades: ≥ 98% by HPLC. CAS No. 151837-09-1. Molecular formula: C10H11N5O5PS · C6H16N. Mole weight: 446.5. | |
Rp-cGMPS Quick inquiry Where to buy Suppliers range | Rp-cGMPS is an inhibitor of protein kinase G Iα with an antagonistic effect of mammalian cyclic nucleotide-dependent phosphodiesterases. Both membrane permeability and kinase specificity of Rp-cGMPS are low. Synonyms: Guanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 86562-09-6. Molecular formula: C10H11N5O6PS · Na. Mole weight: 383.3. | |
Sp-2-AEA-cAMPS-Agarose Quick inquiry Where to buy Suppliers range | Sp-2-AEA-cAMPS-Agarose is the protein kinase A activator Sp-cAMPS immobilized on agarose by an aminoethylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose. | |
Sp-2'-AEC-cAMPS-Agarose Quick inquiry Where to buy Suppliers range | Sp-2'-AEC-cAMPS-Agarose is the protein kinase A activator Sp-cAMPS immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose gel. | |
Sp-2-AHA-cAMPS-Agarose Quick inquiry Where to buy Suppliers range | Sp-2-AHA-cAMPS-Agarose is the protein kinase A activator Sp-cAMPS immobilized on agarose by an aminohexylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer; immobilized on agarose gel. | |
Sp-2'-AHC-cAMPS-Agarose Quick inquiry Where to buy Suppliers range | Sp-2'-AHC-cAMPS-Agarose is the PDE-resistant protein kinase A activator Sp-cAMPS immobilized on agarose by an aminohexylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer; immobilized on agarose gel. | |
Sp-2'-AHC-cGMPS-Agarose Quick inquiry Where to buy Suppliers range | Sp-2'-AHC-cGMPS-Agarose is the PDE-resistant PKG activator Sp-cGMPS immobilized on agarose by an aminohexylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer; immobilized on agarose gel. |