Cyclic Phosphodiesterase Suppliers USA
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Product | Description | |
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2-AEA-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 2-AEA-cAMP-Agarose is the cAMP immobilized on agarose by an aminoethylamino spacer, which can be used in affinity chromatography of different cyclic nucleotide-responsive proteins such as protein kinases and phosphodiesterases. Synonyms: 2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphate, immobilized on agarose. | |
2'-AEC-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 2'-AEC-cAMP-Agarose is the protein kinase A activator cAMP immobilized on agarose by an aminoethylcarbamoyl spacer, wihch can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphate, immobilized on agarose gel. | |
2'-AEC-cGMP-Agarose Quick inquiry Where to buy Suppliers range | 2'-AEC-cGMP-Agarose is the protein kinase G activator cGMP immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
2-AHA-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 2-AHA-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminohexylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
2'-AHC-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 2'-AHC-cAMP-Agarose is the protein kinase A activator cAMP immobilized on agarose by an aminohexylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
2'-AHC-cCMP-Agarose Quick inquiry Where to buy Suppliers range | 2'-AHC-cCMP-Agarose is the putative second messenger cCMP immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chromatography of cCMP-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 2'- O- (2- Aminoethylcarbamoyl)cytidine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
2'-AHC-cGMP-Agarose Quick inquiry Where to buy Suppliers range | 2'-AHC-cGMP-Agarose is the protein kinase G activator cGMP immobilized on agarose by an aminohexylcarbamoyl spacer which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Synonyms: 2'- O- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
2-AH-cGMP-Agarose Quick inquiry Where to buy Suppliers range | 2-AH-cGMP-Agarose is the second messenger cGMP immobilized on agarose by an aminohexyl spacer which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: N2- (6- Aminohexyl)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
2'-[DY505-05]-AHC-cGMP Quick inquiry Where to buy Suppliers range | 2'-[DY505-05]-AHC-cGMP is a fluorescent cGMP analogue (λexc505 nm, λem530 nm) that can be used for phosphodiesterase studies. Synonyms: 2'- O- (6- [DY-505-05]- aminohexylcarbamoyl))guanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C38H37N9O12P · Na. Mole weight: 865.7. | |
2'-Fluo-AHC-cAMP Quick inquiry Where to buy Suppliers range | 2'-Fluo-AHC-cAMP is a fluorescent analogue that can be used for phosphodiesterase studies. Synonyms: 2'- (6-[Fluoresceinyl]aminohexylcarbamoyl) adenosine-3', 5'-cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C38H35N7NaO13P. Mole weight: 851.7. | |
2'-Fluo-AHC-cGMP Quick inquiry Where to buy Suppliers range | 2'-Fluo-AHC-cGMP is a fluorescent cGMP analogue that can be used for phosphodiesterase studies. Synonyms: 2'- (6-[Fluoresceinyl]aminohexylcarbamoyl) guanosine-3', 5'-cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C38H35NNa7O14P. Mole weight: 867.7. | |
2'- (N-Methylanthraniloyl) guanosine 3',5'-Cyclicmonophosphate, Sodium Salt (MANT-cGMP) Quick inquiry Where to buy Suppliers range | A blue fluorescent derivative of cGMP is a useful substrate the assay of cyclic nucleotide phosphdiesterase. Also inhibits calmodulin-dependent activation of cyclic nucleotide phosphodiesterase by peptide segments of HIV envelope glycoproteins has been monitored using MANT-cGMP.Fluorescence: max. Abs. 359nm; max. Em. 448nm; e x 10-3: 5.2. Group: Biochemicals. Alternative Names: Cyclic 3,5-(hydrogen phosphate) 2-[2-(methylamino)benzoate] Guanosine Monosodium Salt; MANT-cGMP. Grades: Highly Purified. CAS No. 221905-46-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
2'-O- (N'-Methylanthraniloyl) guanosine-3', 5'-cyclic Monophosphate Quick inquiry Where to buy Suppliers range | 2'-O- (N'-Methylanthraniloyl) guanosine-3', 5'-cyclic Monophosphate is a substrate for phosphodiesterase studies. Group: Biochemicals. Grades: Highly Purified. CAS No. 83707-15-7. Pack Sizes: 10µmol, 25µmol. Molecular Formula: C18H19N6O8P, Molecular Weight: 478.35. US Biological Life Sciences. | Worldwide |
2'-TAMRA-AEC-cGMP Quick inquiry Where to buy Suppliers range | 2'-TAMRA-AEC-cGMP is a fluorescent cGMP analogue (λexc555 nm, λem580 nm) that can be used for phosphodiesterase studies. Synonyms: 2'- O- (2- [Tetramethylrhodaminyl] aminoethylcarbamoyl) guanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C38H37N9O12P · Na. Mole weight: 865.7. | |
2'-TAMRA-AHC-cGMP Quick inquiry Where to buy Suppliers range | 2'-TAMRA-AHC-cGMP is a fluorescent cGMP analogue (λexc555 nm, λem580 nm) that can be used for phosphodiesterase studies. Synonyms: 2'- O- (6- [Tetramethylrhodaminyl] aminohexylcarbamoyl) guanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C42H45N9O12P · Na. Mole weight: 921.8. | |
5,6-DCl-cBIMP Quick inquiry Where to buy Suppliers range | 5,6-DCl-cBIMP is a potent activator of protein kinase A, acting on both type I and II. It can be subsequently metabolized by cyclic nucleotide-dependent phosphodiesterases. Synonyms: 5, 6- Dichlorobenzimidazole riboside- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 129693-10-3. Molecular formula: C12H10Cl2N2O6P · Na. Mole weight: 403.1. | |
6-AE-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 6-AE-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminoethyl spacer which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. | |
6-AH-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 6-AH-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminohexyl spacer which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. | |
6-Cl-cPuMP Quick inquiry Where to buy Suppliers range | 6-Cl-cPuMP is an analogue of cAMP which exhibits better membrane permeability and higher stability against phosphodiesterases. Synonyms: 6- Chloropurine riboside- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 94200-58-5. Molecular formula: C10H9ClN4O6P · Na. Mole weight: 370.6. | |
8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate - DY-480XL Quick inquiry Where to buy Suppliers range | DY-480XL, a biomedicine product specialized in biochemical studies, offers an intricate solution to understanding the dynamics of enzymatic interactions and signaling pathways. As a fluorescent analog of 2',5'-ADP, this product boasts the capability to study complex enzyme activities such as adenylate cyclase and cyclic nucleotide phosphodiesterase. Furthermore, it can delve into the intricate signaling pathways activated by extracellular receptors, which induce G protein-coupled pathways. The product's versatility renders it invaluable in the oncology research sphere, with its potential applications ranging from breast, ovarian to colon cancer. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate, labeled with DY 480XL, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C42H57N9O16P2S (free acid). Mole weight: 1037.97 (free acid). | |
8-[(6-Amino)hexyl]-amino-cAMP - 6-JOE Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-cAMP - 6-JOE, a fluorescent analog of cyclic AMP, presents immense academic value as a research tool for investigating cellular signaling pathways through adenylyl cyclase and phosphodiesterase activity, as well as cAMP receptor binding. Its diverse potential applications to the regulation of cellular signaling in diseases such as diabetes and heart disease, underscores its profound scientific relevance. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-cyclic monophosphate, labeled with 6-JOE, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C39H38Cl2N7O14P (free acid). Mole weight: 929.16 (free acid). | |
8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho11 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-Rho11 is an indispensable fluorescent probe of significant value in biomedical research for the efficient imaging of cGMP signaling pathways. Its comprehensive functionality further extends to aiding in the effective visualization of cGMP activity across diverse cell types, including neurons and smooth muscle cells. Numerous studies have showcased the presence of cGMP signaling in blood pressure regulation, platelet aggregation, and smooth muscle relaxation, under the influence of nitric oxide. Moreover, cGMP levels can be efficiently monitored by this probe, in sync with the effects of phosphodiesterase inhibitors. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO Rho11, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C51H63N10O10P (free acid). Mole weight: 1006.44 (free acid). | |
8-AEA-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 8-AEA-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminoethylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphate, immobilized on agarose gel. | |
8-AET-2'-O-Me-cAMP Quick inquiry Where to buy Suppliers range | 8-AET-2'-O-Me-cAMP is a ligand in affinity chromatography of cAMP binding proteins that do not require an intact 2'-OH group, such as the exchange protein activated by cAMP (Epac) and certain phosphodiesterases. Synonyms: 8- (2- Aminoethylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 634207-89-9. Molecular formula: C13H18N6O6PS · Na. Mole weight: 440.4. | |
8-AET-2'-O-Me-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 8-AET-2'-O-Me-cAMP-Agarose is the second messenger cAMP with a methylated ribose 2'-hydroxyl group immobilized on agarose by an aminoethylthio spacer, which can be used in affinity chromatography of cAMP-responsive proteins such as the exchange protein activated by cAMP (Epac) and certain phosphodiesterases. Synonyms: 8- (2- Aminoethylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, immobilized on agarose gel. | |
8-AET-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 8-AET-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminoethylthio spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 8- (2- Aminoethylthio)adenosine- 3', 5'- cyclic monophosphate, immobilized on agarose gel. | |
8-AET-cGMP-Agarose Quick inquiry Where to buy Suppliers range | 8-AET-cGMP-Agarose is the second messenger cGMP immobilized on agarose by an aminoethylthio spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 8- (2- Aminoethylthio)guanosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
8-AHA-2'-O-Me-cAMP Quick inquiry Where to buy Suppliers range | 8-AHA-2'-O-Me-cAMP is a ligand in affinity chromatography of cAMP binding proteins that do not require an intact 2'-OH group, such as the exchange protein activated by cAMP (Epac) and certain phosphodiesterases. Synonyms: 8- (6- Aminohexyl)amino- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate. Grades: ≥ 98% by HPLC. Molecular formula: C17H28N7O6P. Mole weight: 457.4. | |
8-AHA-2'-O-Me-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 8-AHA-2'-O-Me-cAMP-Agarose is the second messenger cAMP with a methylated ribose 2'-hydroxy group immobilized on agarose by an aminohexylamino spacer, which can be used in affinity chromatography of cAMP-responsive proteins such as the exchange protein activated by cyclic AMP (Epac) and certain phosphodiesterases. Synonyms: 8- (6- Aminohexylamino)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
8-AHA-cAMP-Agarose Quick inquiry Where to buy Suppliers range | 8-AHA-cAMP-Agarose is the second messenger cAMP immobilized on agarose by an aminohexylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Synonyms: 8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel. | |
8-CPT-6-Phe-cAMP Quick inquiry Where to buy Suppliers range | 8-CPT-6-Phe-cAMP is a selective activator of protein kinase A (cAMP agonist). It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Grades: ≥ 98% by HPLC. CAS No. 72549-36-1. Molecular formula: C22H18ClN5O6PS·Na. Mole weight: 569.9. | |
8-CPT-cAMP Quick inquiry Where to buy Suppliers range | 8-CPT-cAMP is an activator of cAMP- and cGMP-dependent protein kinase and of Epac. It has an improved membrane permeability, phosphodiesterase stability and selectivity for site B of cAK type II. Uses: Enzyme inhibitors. Synonyms: 8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 93882-12-3. Molecular formula: C16H14ClN5O6PS · Na. Mole weight: 493.8. | |
8-Methoxymethyl-1-methyl-3-(2-methylpropyl) Xanthine (8-Methoxymethyl-IBMX) Quick inquiry Where to buy Suppliers range | A specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase. Group: Biochemicals. Alternative Names: 8-Methoxymethyl-IBMX. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
8-OH-cAMP Quick inquiry Where to buy Suppliers range | 8-OH-cAMP is a polar analogue of cAMP used for the study of extracellular cAMP receptors. When applied by patch clamp techniques, 8-OH-cAMP remains trapped inside the cell. It exhibits a resistant effect of mammalian cyclic nucleotide-dependent phosphodiesterases. Synonyms: 8- Hydroxyadenosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 31356-95-3. Molecular formula: C10H11N5O7P · Na. Mole weight: 367.2. | |
8-pCPT-cGMP Quick inquiry Where to buy Suppliers range | 8-pCPT-cGMP is a selective activator of cGMP-dependent protein kinase type I α and type II, as well as of cGMP-gated ion channels. It has higher membrane permeability and stability towards many phosphodiesterases. Synonyms: 8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 51239-26-0. Molecular formula: C16H14ClN5O7PS · Na. Mole weight: 509.8. | |
8-pCPT-PET-cGMP Quick inquiry Where to buy Suppliers range | 8-pCPT-PET-cGMP is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to 8-Br-PET-cGMP, 8-pCPT-PET-cGMP is much more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. Molecular formula: C24H18ClN5O7PS · Na. Mole weight: 609.9. | |
Adenosine 3,5-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt (8-CPT-cAMP, Na) Quick inquiry Where to buy Suppliers range | Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC50=900nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC50=25uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 93882-12-3. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?PS · Na. US Biological Life Sciences. | Worldwide |
Adenosine 3,5-cyclic Monophosphate, 8-Bromo-, Sodium Salt (8-Bromo-cAMP, Na) Quick inquiry Where to buy Suppliers range | Cell-permeable cAMP analog that has greater resistance to phosphodiesterases than cAMP. Preferentially activates protein kinase A (PKA). Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Group: Biochemicals. Grades: Highly Purified. CAS No. 76939-46-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Adenosine 3?,5?-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 Quick inquiry Where to buy Suppliers range | Cell-permeable cAMP analog that has greater resistance to phosphodiesterases than cAMP. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 76939-46-3. Pack Sizes: 10MG. Mole weight: 430.08. Catalog: AP76939463. Assay: ≥98% (HPLC). | |
Adenosine 3,5-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt (6-Bnz-cAMP, Na) Quick inquiry Where to buy Suppliers range | A potent cell-permeable activator of cAMP-dependent protein kinase (PKA). Activates both type 1 and type 2 PKA and binds to the cAMP binding site 2 on the regulatory subunit of PKA. It is only slowly metabolized by cyclic nucleotide-dependent phosphodiesterases. Due to its considerably increased lipophilicity, it has sufficient membrane permeability for many biological systems. Group: Biochemicals. Grades: Highly Purified. CAS No. 30275-80-0. Pack Sizes: 10umol. US Biological Life Sciences. | Worldwide |
Adenosine 3,5-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt (Adenosine 3,5-cyclic Phosphorothioate-Rp, Rp-cAMPS, TEA, PKA Inhibitor V) Quick inquiry Where to buy Suppliers range | A cell-permeable and reversible inhibitor of protein kinase A (Ki = 11uM). Resistant to hydrolysis by phosphodiesterases. Noncompetitive with respect to ATP. Group: Biochemicals. Grades: Highly Purified. CAS No. 151837-09-1. Pack Sizes: 5umol. US Biological Life Sciences. | Worldwide |
AICAR 3,5-Cyclic Phosphate Quick inquiry Where to buy Suppliers range | A cyclic nucleotides with protein kinase and phosphodiesterase activity. Group: Biochemicals. Alternative Names: 5-Aminoimidazole-4-carboxamide-1- β-D-ribofuranosyl 3:5-cyclic-monophosphate;5-Amino-1-(3,5-O-phosphinico- β-D-ribofuranosyl)-1H-imidazole-4-carboxamide; NSC 371796. Grades: Highly Purified. CAS No. 35908-14-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
AICAR 3',5'-Cyclic Phosphate Quick inquiry Where to buy Suppliers range | A cyclic nucleotide with protein kinase and phosphodiesterase activity. Synonyms: 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 3':5'-cyclic-monophosphate;5-Amino-1-(3,5-O-phosphinico-β-D-ribofuranosyl)-1H-imidazole-4-carboxamide; NSC 371796. Grades: 94%. CAS No. 35908-14-6. Molecular formula: C9H13N4O7P. Mole weight: 320.2. | |
Anagrelide Quick inquiry Where to buy Suppliers range | Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity with IC50 value of 36 nM for inhibition of phosphodiesterase 3. It inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte hyperproliferation and differentiation. It is antithrombocythemic used for the treatment of overproduction of blood platelets. It is a synthetic quinazoline derivative and is used as is a platelet-reducing agent. It reduces platelet production through a decrease in megakaryocyte maturation. It inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. It is a drug used for the treatment of essential thrombocytosis or overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia. It was developed by Shire and has been listed. Uses: Anagrelide is used for the treatment of overproduction of blood platelets. it is a drug used for the treatment of essential thrombocytosis or overproduction of blood platelets. it also has been used in the treatment of chronic myeloid leukemia. Synonyms: 6,7-Dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one;6-Chloro-1,2,3,5-tetrahydro iMidazo [2, 1-b]quinazolin-2-one; Agrelin; Agrylin; Xagrid; Shire; Thromboreductin. Grades: 98%. CAS No. 68475-42-3. Molecular formula: C10H7Cl2N3O. Mole weight: 256.09. | |
APD-I Quick inquiry Where to buy Suppliers range | APD-I is an ester peptide antibiotic produced by Bacillus subtilis C-756. It can inhibit the activity of cyclic-AMP phosphodiesterase. CAS No. 87098-49-5. Molecular formula: C51H89N7O13. Mole weight: 1008.29. | |
APD-II Quick inquiry Where to buy Suppliers range | APD-II is an ester peptide antibiotic produced by Bacillus subtilis C-756. It can inhibit the activity of cyclic-AMP phosphodiesterase. CAS No. 87099-78-3. Molecular formula: C52H91N7O13. Mole weight: 1022.32. | |
APD-III Quick inquiry Where to buy Suppliers range | APD-III is an ester peptide antibiotic produced by Bacillus subtilis C-756. It can inhibit the activity of cyclic-AMP phosphodiesterase. CAS No. 87098-48-4. Molecular formula: C53H93N7O13. Mole weight: 1036.34. | |
Caffeidine Quick inquiry Where to buy Suppliers range | Caffeidine is an impurity of Caffeine (C080100), a xanthine alkaloid that acts as a stimulant drug and a reversible acetylcholinesterase inhibitor. Caffeidine have also shown inhibitory activity towards cyclic nucleotide phosphodiesterases. Group: Biochemicals. Alternative Names: N,1-Dimethyl-4-(methylamino)imidazole-5-carboxamide; EP Impurity E. Grades: Highly Purified. CAS No. 20041-90-1. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
Caffeine Impurity E Quick inquiry Where to buy Suppliers range | Caffeidine is an impurity of Caffeine (C080100), a xanthine alkaloid that acts as a stimulant drug and a reversible acetylcholinesterase inhibitor. Caffeidine have also shown inhibitory activity towards cyclic nucleotide phosphodiesterases. Synonyms: Caffeidine; 1H-Imidazole-5-carboxamide, N,?1-dimethyl-4-(methylamino)?-, hydrochloride. Grades: > 95%. CAS No. 20041-90-1. Molecular formula: C7H12N4O. Mole weight: 168.2. | |
CHF-6001 Quick inquiry Where to buy Suppliers range | This active molecular is a Type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor originated by Chiesi Farmaceutici with IC50 value of 0.026 ± 0.006 nM. CHF6001 inhibited PDE4 isoforms A to D with equal potency, showed an elevated ratio of high-affinity rolipram binding site versus low-affinity rolipram binding site and displayed >20,000-fold selectivity versus PDE4 compared with a panel of PDEs. In May 2016, Chiesi completed a phase I trial in Chronic Obstructive Pulmonary Disease (In volunteers) in United Kingdom (Inhalation). In Oct 2016, Phase-II clinical trials in Chronic obstructive pulmonary disease (Adjunctive treatment) in Hungary (Inhalation) was on-going. Uses: Allergic asthma; chronic obstructive pulmonary disease. Synonyms: CHF-6001; CHF 6001; CHF6001. UNII-0984EU6E2F; 0984EU6E2F; CHEMBL3113974; SCHEMBL12096092; CHF6001; VCFBPAOSTLMYIV-SANMLTNESA-N;[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl] 3-(cyclopropylmethoxy)-4-(methanesulfonamido)benzoate. Grades: 98%. CAS No. 1239278-59-1. Molecular formula: C30H30Cl2F2N2O8S. Mole weight: 687.53. | |
Cilostazol Quick inquiry Where to buy Suppliers range | Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake. Uses: Bronchodilator agents. Synonyms: AT2266; CI919; Pd107779; NSC629661; AT 2266; CI 919; Pd 107779; NSC 629661; AT-2266; CI-919; Pd-107779; NSC-629661. Grades: >98%. CAS No. 73963-72-1. Molecular formula: C20H27N5O2. Mole weight: 369.46. | |
CK-2289 Quick inquiry Where to buy Suppliers range | CK-2289 is an type III cyclic 3'5'-adenosine monophosphate phosphodiesterase inhibitor. It may be used in the treatment of congestive heart failure. Uses: Ck-2289 may be used in the treatment of congestive heart failure. Synonyms: CK 2289; CK-2289; CK2289. 4-[4-(1H-Imidazol-1-yl)benzoyl]-5-ethyl-1H-imidazol-2(3H)-one;4-Ethyl-5-[4-(1H-imidazol-1-yl)benzoyl]-1H-imidazol-2(3H)-one;2H-Imidazol-2-one,4-ethyl-1,3-dihydro-5-[4-(1H-imidazol-1-yl)benzoyl]-;4-Ethyl-1,3-dihydro-5-[4-(1H-imidazol-1-yl)benzoyl]-2H-imidazol-2-one. Grades: >98 %. CAS No. 101183-99-7. Molecular formula: C15H14N4O2. Mole weight: 282.30. | |
CP-220629 Quick inquiry Where to buy Suppliers range | CP-220629, a Pyrazolopyridin derivative, has been found to be a Type 4 cyclic nucleotide phosphodiesterase inhibitor that was once studied as an anti-inflammatory as well as antiasthmatic agent. Synonyms: UNII-BAV9N49AFE; CP-220629; CP 220629; CP220629; BAV9N49AFE; SCHEMBL84865; CHEMBL75819; 1-cyclopentyl-3-ethyl-6-(2-methylphenyl)-4,5-dihydropyrazolo[3,4-c]pyridin-7-one. Grades: 98%. CAS No. 162141-96-0. Molecular formula: C20H25N3O. Mole weight: 323.44. | |
CP 461 Quick inquiry Where to buy Suppliers range | CP 461, belonging to a class of novel proapoptotic drugs with antineoplastic effect, specifically inhibit cyclic GMP phosphodiesterases but not cyclooxygenase-1 or -2. Synonyms: CP 461; CP-461; CP461; OSI 461; UNII-68OJX9I7DT. N-benzyl-2-[6-fluoro-2-methyl-3-(pyridin-4-ylmethylidene)inden-1-yl]acetamide;hydrochloride; CAS: 227619-92-3 (CP-461 free base). Grades: >98%. CAS No. 227619-96-7. Molecular formula: C25H22ClFN2O. Mole weight: 420.91. | |
CP-461 free base Quick inquiry Where to buy Suppliers range | CP 461, belonging to a class of novel proapoptotic drugs with antineoplastic effect, specifically inhibit cyclic GMP phosphodiesterases but not cyclooxygenase-1 or -2. Synonyms: CP-461 free base; CP 461 free base; CP461 free base; N-benzyl-2-[(3Z)-6-fluoro-2-methyl-3-(pyridin-4-ylmethylidene)inden-1-yl]acetamide; UNII-824ZMS3BGL; OSI-461 free base. Grades: >98%. CAS No. 227619-92-3. Molecular formula: C25H21FN2O. Mole weight: 384.45. | |
Etofylline Quick inquiry Where to buy Suppliers range | An inhibitor of 3,5-Cyclic Nucleotide Phosphodiesterase. Therapeutically, this compound has diuretic, muscle relaxant, bronchial dilation and CNS stimulant activities. Group: Biochemicals. Alternative Names: 7- (2-Hydroxyethyl) theophylline; 3,7-Dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-1H-purine-2,6-dione; 7-(2-Hydroxyethyl)-1,3-dimethylxanthine; 7-Theophyllineethanol; Aethophyllinum; Ascorphylline; Bio-phylline; Cordalin; Corophyllin-N; Dilaphyllin; Etophyllin; Etophylline; Frekaphyllin; hydroxyethyl theophyl line; KT 200G; NSC 113373; Oxphylline; Oxyethophylline; Oxyethyltheophylline; Oxyphyllin; Oxyphylline; Oxytheonyl; Phyllocormin N; Soluphylline. Grades: Highly Purified. CAS No. 519-37-9. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
Etofylline Quick inquiry Where to buy Suppliers range | β-hydroxyethyltheophylline is an inhibitor of 3',5'-Cyclic Nucleotide Phosphodiesterase. Uses: An inhibitor of 3',5'-cyclic nucleotide phosphodiesterase. Synonyms: BRN 0251760; BRN-0251760; BRN0251760; 7-(2-Hydroxyethyl)theophylline;β-hydroxyethyltheophylline. Grades: ≥95%. CAS No. 519-37-9. Molecular formula: C9H12N4O3. Mole weight: 224.21. | |
Filaminast Quick inquiry Where to buy Suppliers range | Filaminast is a Type 4 cyclic nucleotide phosphodiesterase inhibitor. It is an analog of rolipram which served as a prototype molecule for several development efforts. In Oct 1999, phase II clinical trials for Asthma in European Union was discontinued. Uses: Asthma. Synonyms: UNII-CDD69JC61J; Way-pda-641; WAY-PDA 641; WAY-PDA-641; CDD69JC61J; SCHEMBL73843; 1-(3-(Cyclopentyloxy)-4-methoxyphenyl)ethanone-(E)-O-(aminocarbonyl)oxime. Grades: 98%. CAS No. 141184-34-1. Molecular formula: C15H20N2O4. Mole weight: 292.33. | |
FR-229934 Quick inquiry Where to buy Suppliers range | FR-229934 is a Type 5 cyclic nucleotide phosphodiesterase inhibitor. In Feb 2008, preclinical for Erectile dysfunction in Japan was discontinued. Uses: Erectile dysfunction. Synonyms: FR-229934; FR229934; FR 229934. 1-((3,4-dichlorophenyl)methyl)-2-methyl-N-(pentylsulfonyl)-1H-Benzimidazole-6-carboxamide. Grades: 98%. CAS No. 799841-02-4. Molecular formula: C21H23Cl2N3O3S. Mole weight: 468.40. | |
Griseolic acid A Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces griseoaurantiacus SANK43894. It has the activity of inhibiting cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17] with IC50 0.16 X 10-6 mol/L (Extracted from rat brain). Griseolic acid A can stimulate the flow of glycogen and increase the blood sugar level in mice. Synonyms: griseolic acid; 1-(6-Amino-9H-purin-9-yl)-3,6-anhydro-6-C-carboxy-1,5-dideoxy-α-L-talo-4-octenofuranuronic acid. CAS No. 79030-08-3. Molecular formula: C14H13N5O8. Mole weight: 379.28. | |
Griseolic acid B Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces griseoaurantiacus SANK43894. It has the activity of inhibiting cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17] with IC50 0.16 X 10-6 mol/L (Extracted from rat brain). Synonyms: (2R,5R,6R,6aS)-5-(6-amino-9H-purin-9-yl)-2-(carboxymethyl)-6-hydroxy-2,5,6,6a-tetrahydrofuro[3,2-b]furan-2-carboxylic acid; Deoxygriseolic Acid; 1-(6-Amino-9H-purin-9-yl)-3,6-anhydro-6-C-carboxy-1,5,7-trideoxy-β-D-ribo-4-octenofuranuronic acid; 7'-Desoxygriseolic acid. CAS No. 98890-01-8. Molecular formula: C14H13N5O7. Mole weight: 363.28. | |
Griseolic acid C Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces griseoaurantiacus SANK43894. It has the activity of inhibiting cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17] with IC50 0.12 X 10-6 mol/L (Extracted from rat brain). Synonyms: (3aR,5R,6R,6aS)-5-(6-amino-9H-purin-9-yl)-2-(carboxymethyl)-6-hydroxyhexahydrofuro[3,2-b]furan-2-carboxylic acid; beta-D-allo-Octofuranuronic acid, 1-(6-amino-9H-purin-9-yl)-3,6-anhydro-6-C-carboxy-1,5,7-trideoxy-. CAS No. 100242-49-7. Molecular formula: C14H15N5O7. Mole weight: 365.30. | |
GSK-356278 Quick inquiry Where to buy Suppliers range | GSK-356278 is a selective Type 4 cyclic nucleotide phosphodiesterase inhibitor. It shows anxiolytic and cognition-enhancing effects and it has the ability to elevate cAMP in various cell types of the central nervous system. No development was reported for phase-I development in Major depressive disorder and Huntington's-disease. Uses: Huntington's disease; major depressive disorder. Synonyms: GSK-356278; GSK356278; GSK 356278; 5-(5-((2,4-dimethyl-5-thiazolyl)methyl)-1,3,4-oxadiazol-2-yl)-1-ethyl-n-(tetrahydro-2H-pyran-4-yl)-1H-Pyrazolo(3,4-b)pyridin-4-amine. Grades: 98%. CAS No. 720704-34-7. Molecular formula: C21H25N7O2S. Mole weight: 439.54. | |
Guanosine 3,5-Cyclic-13C,15N2 Monophosphate Quick inquiry Where to buy Suppliers range | Labeled Guanosine 3,5-Cyclic Monophosphate. Guanosine 3,5-Cyclic Monophosphate is a substituted Guanosine having cyclic phosphodiesterase activity. Group: Biochemicals. Alternative Names: Guanosine Cyclic-13C,15N2 3,5-(Hydrogen phosphate); Cyclic 3,5-Guanosine-13C,15N2 Monophosphate; Guanosine-13C,15N2 Monophosphate; GMP-13C,15N2. Grades: Highly Purified. CAS No. 40732-48-7-unlabeled. Pack Sizes: 500ug. Molecular Formula: C?¹³CH??N?¹?N?O?P, Molecular Weight: 348.18. US Biological Life Sciences. | Worldwide |
Guanosine 3?,5?-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 51116-01-9 Quick inquiry Where to buy Suppliers range | Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 51116-01-9. Pack Sizes: 25MG. Mole weight: 446.08. Catalog: AP51116019-B. Assay: ≥98% (HPLC). | |
IBMX (3-Isobutyl-1-methylxanthine) Quick inquiry Where to buy Suppliers range | 3-isobutyl-1-methylxanthine (IBMX) is a nonselective inhibitor of cAMP and cGMP phosphodiesterases (PDEs). Research studies show that IBMX inhibits many members of the PDE family, with the exceptions of PDE8A, PDE8B, and PDE9 (1-4). Treatment of cells with IBMX promotes accumulation of cAMP and cGMP, which leads to activation of cyclic- nucleotide- regulated protein kinases (5,6). Additional research indicates that IBMX can promote neuronal progenitor cell maturation in vitro (7). Group: Biochemicals. Grades: Highly Purified. CAS No. 28822-58-4. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
Ibudilast Quick inquiry Where to buy Suppliers range | Ibudilast is a nonselective inhibitor of cyclic nucleotide phosphodiesterase (PDE) which has been marketed for treating asthma. It crosses the blood-brain barrier, is well tolerated, is active on oral administration, reduces glial activation and attenuates pain symptoms in diverse rat models of neuropathic pain. In addition, it enhances acute morphine analgesia and attenuates morphine tolerance and withdrawal. Thus ibudilast may improve opioid efficacy and is a promising therapeutic candidate for neuropathic pain. Synonyms: MN-166, MN166, MN 166, AV-411, AV 411, AV411, KC404; KC-404; KC 404; Ibudilast. Grades: >98%. CAS No. 50847-11-5. Molecular formula: C14H18N2O. Mole weight: 230.31. | |
Indimilast Quick inquiry Where to buy Suppliers range | Indimilast is a phosphodiesterase IV inhibitor. It modulates lung inflammation and cause bronchodilation by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cells. It is potential useful in chronic obstructive pulmonary disease(COPD). Uses: Indimilast is potential useful in chronic obstructive pulmonary disease(copd). Synonyms: N-[4-[1-[3-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]-6-fluoro-2,4-dioxopyrido[2,3-d]pyrimidin-3-yl]cyclohexyl]-2-methyl-1,3-thiazole-4-carboxamide;N-{cis-4-[1-(4'-{[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl}[1,1'-biphenyl]-3-yl)-6-fluoro-2,4-dioxo-1,4-dihydropyrido[2,3-d]pyrimidin-3(2H)-yl]cyclohexyl}-2-methyl-1,3-thiazole-4-carboxamide. Grades: >98 %. CAS No. 1038825-85-2. Molecular formula: C37H40FN7O3S. Mole weight: 681.83. | |
K 259-2 Quick inquiry Where to buy Suppliers range | K-259-2, a new inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, was isolated from the cultured broth of Micromonospora olivasterospora K-259. IC50 values for the effect of K-259-2 against Ca2+ and calmodulin-stimulated activity of the enzyme preparations from bovine brain and heart were 6.6 and 2.9 microM, respectively. Synonyms: K-259-2; 1,6,8-Trihydroxy-3-[(Z)-2-ethyl-2-butenyl]-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid. CAS No. 102819-46-5. Molecular formula: C21H18O7. Mole weight: 382.36. | |
KS-501 Quick inquiry Where to buy Suppliers range | It is produced by the strain of Sporothrix sp. KAC-1989. KS-501 inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 1.8 μmol/L. Synonyms: KS 501; 3-Heptyl-5-hydroxyphenyl 2-heptyl-6-(hexofuranosyloxy)-4-hydroxybenzoate. CAS No. 120634-86-8. Molecular formula: C33H48O10. Mole weight: 604.73. |