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| Product | Description | |
|---|---|---|
| Cyclosporin A | 100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C62H111N11O12. CAS No. 59865-13-3. Prepack ID 40007313-100mg. Molecular Weight 1202.61. See USA prepack pricing. |  |
| Cyclosporin A | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C62H111N11O12. CAS No. 59865-13-3. Prepack ID 40007313-1g. Molecular Weight 1202.61. See USA prepack pricing. | |
| Cyclosporin A | Cyclosporin A (Cyclosporine A) is an immunosuppressant that binds to cyclophilins, inhibiting calcineurin activity with an IC50 of 7 nM. It also inhibits CD11a/CD18 adhesion molecules. Synonyms: Ciclosporin; cyclosporine; Cyclosporine A; Sandimmun; Cyclosporin; Neoral; Ciclosporine; Sandimmune; Ramihyphin A. Grades: 98%. CAS No. 59865-13-3. Molecular formula: C62H111N11O12. Mole weight: 1202.61. |  |
| Cyclosporin A | Potent immunosuppressant (same as FK-506 and rapamycin). Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phos- phatase 2B (PP2B; calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells (NFAT) transcription factor, leading to disruption of T cell activation. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2). Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis). Antibacterial. Antifungal. Antiparasitic. Apoptosis inhibitor. Inhibits the mitochondrial permeability transition pore (MPTP) from opening, thus inhibiting cytochrome c release. NF-kappaB suppressor by induction of unfolded protein response (UPR). Anti-cancer compound. Apoptosis and autophagy inducer. Inhibits n Group: Biochemicals. Alternative Names: Antibiotic S 7481F1; Ciclosporin A; CsA; Cyclosporine; NSC 290193; Ramihyphin A; Sandimmun; Sandimmune; Neoral; Optimmune; Restasis; OL 27-400. Grades: Highly Purified. CAS No. 59865-13-3. Pack Sizes: 5g, 10g. US Biological Life Sciences. |  Worldwide |
| Cyclosporin A-13C2,d4 Acetate | Labeled Cyclosporin A derivative. An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity. Group: Biochemicals. Alternative Names: Cyclosporine-13C2,d4 Acetate; Ciclosporin-13C2,d4 Acetate; Atopica-13C2,d4 Acetate; Sandimmun(e)-13C2,d4 Acetate; Neoral-13C2,d4 Acetate; Optimmune-13C2,d4 Acetate; Restasis-13C2,d4 Acetate. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin A-13C2,d4 (Major). | An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Group: Biochemicals. Alternative Names: Cyclosporine-13C2,d4; Ciclosporin-13C2,d4; Atopica-13C2,d4; Sandimmun(e)-13C2,d4; Neoral-13C2,d4; Optimmune-13C2,d4; Restasis-13C2,d4. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Cyclosporin A 8-N-MeAla | Cyclosporin A 8-N-MeAla. Uses: For analytical and research use. Group: Impurity standards. CAS No. 108466-41-7. Molecular Formula: C63H113N11O12. Mole Weight: 1216.66. Catalog: APB108466417. |  |
| Cyclosporin A, 9-(N-methyl-L-Isoleu) | Cyclosporin A, 9-(N-methyl-L-Isoleu). Uses: For analytical and research use. Group: Impurity standards. CAS No. 143205-42-9. Molecular Formula: C62H111N11O12. Mole Weight: 1202.64. Catalog: APB143205429. | |
| Cyclosporin A, 9-(N-methyl-L-valine) | Cyclosporin A, 9-(N-methyl-L-valine). Uses: For analytical and research use. Group: Impurity standards. CAS No. 156047-28-8. Molecular Formula: C61H109N11O12. Mole Weight: 1188.61. Catalog: APB156047288. | |
| Cyclosporin A Acetate | A non-immunosuppressive analog. Group: Biochemicals. Alternative Names: 6-[(2S,3R,4R,6E)-3-(Acetyloxy)-4-methyl-2-(methylamino)-6-octenoic acid] Cyclosporin A; B 3-243; O-Acetyl-C91-cyclosporin A; O-Acetylcyclosporin A; SDZ 33-243. Grades: Highly Purified. CAS No. 83602-41-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin A-d4 Acetate (Major) | A non-immunosuppressive analog. Group: Biochemicals. Alternative Names: 6-[(2S,3R,4R,6E)-3-(Acetyloxy)-4-methyl-2-(methylamino)-6-octenoic-d4 acid] Cyclosporin A; B 3-243-d4; O-Acetyl-C91-cyclosporin A-d4; O-Acetylcyclosporin A-d4; SDZ 33-243-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin A-d4 (Major) | An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Group: Biochemicals. Alternative Names: Cyclosporine-d4; Ciclosporin-d4; Atopica-d4; Sandimmun(e)-d4; Neoral-d4; Optimmune-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin A-Derivative 1 | Cyclosporin A-Derivative 1 is a metabolite of cyclosporine A. Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin phosphatase. Synonyms: Leu-Val-Leu-Ala-D-Ala-Leu-Leu-Val-Aaa-Abu-Sar.BF4; (7S, 10S, 13S, 16S, 19S, 22R, 25S, 28S, 31S, 34S)-10-[(1R, 2R, 4E)-1-Acetoxy-2-methyl-4-hexen-1-yl]-7-ethyl-16, 19, 28-triisobutyl-13, 31-diisopropyl-N, 5, 11, 14, 17, 20, 22, 25, 29, 36-decamethyl-3, 6, 9, 12, 15, 18, 21, 24, 27, 3 0,33-undecaoxo-2-oxa-5,8,11,14,17,20,23,26,29,32-decaazaheptatriacontan-34-aminium tetrafluoroborate. Grades: ≥98%. CAS No. 1487360-85-9. Molecular formula: C65H118BF4N11O14. Mole weight: 1364.50. | |
| Cyclosporin A-Derivative 1 Free base | Cyclosporin A-Derivative 1 Free base is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: Cyclosporin A open ring; N-Methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methyl-glycine Methyl Ester; Cyclosporin A-Derivative 1 (Free base); Cyclosporin A seco(MeGly-MeLeu) Methyl Ester; Leu-Val-Leu-Ala-{d-Ala}-Leu-Leu-Val-{Aaa}-{Abu}-{Sar}; LVLA-{d-Ala}-LLV-{Aaa}-{Abu}-{Sar}. Grades: ≥95%. CAS No. 286852-20-8. Molecular formula: C65H117N11O14. Mole weight: 1276.69. | |
| Cyclosporin A Isomer | Cyclosporin A Isomer. Uses: For analytical and research use. Group: Impurity standards. CAS No. 59865-16-6. Molecular Formula: C62H111N11O12. Mole Weight: 1202.64. Catalog: APB59865166. | |
| Cyclosporin AM 1 | A cyclosporine metabolite specifically inhibits growth of renal cells in culture. Group: Biochemicals. Alternative Names: 6-[(2S,3R,4R,6E)-3,8-Dihydroxy-4-methyl-2-(methylamino)-6-octenoic acid]cyclosporin A; Cyclosporin A Metabolite 17; Cyclosporin Metabolite 17; M 17; OL 17. Grades: Highly Purified. CAS No. 89270-28-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin AM 1 | Cyclosporin AM 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 89270-28-0. Molecular Formula: C62H111N11O13. Mole Weight: 1218.63. Catalog: APB89270280. | |
| Cyclosporin AM 3 | Cyclosporin AM 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 153049-50-4. Molecular Formula: C62H111N11O13. Mole Weight: 1218.63. Catalog: APB153049504. | |
| Cyclosporin AM 4 | Cyclosporin AM 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 89270-23-5. Molecular Formula: C61H109N11O12. Mole Weight: 1188.61. Catalog: APB89270235. | |
| Cyclosporin AM 4N | Cyclosporin AM 4N is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: 9-L-Leucinecyclosporin A; 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane Cyclic Peptide Deriv; AM 4N; Cyclosporin A Metabolite 21; M 21; OL 21; [Leu4]cyclosporin. Grades: ≥90% by HPLC. CAS No. 89270-23-5. Molecular formula: C61H109N11O12. Mole weight: 1188.58. | |
| Cyclosporin AM 6 | Cyclosporin AM 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 154334-72-2. Molecular Formula: C59H107N11O12. Mole Weight: 1162.57. Catalog: APB154334722. | |
| Cyclosporin AM 7 | Cyclosporin AM 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 132362-39-1. Molecular Formula: C61H109N11O13. Mole Weight: 1204.61. Catalog: APB132362391. | |
| Cyclosporin AM 9 | Cyclosporin AM 9 is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: (4-Hydroxy-N-methyl-L-leucine)cyclosporine; 3-(4-Hydroxy-N-methyl-L-leucine)cyclosporin A; Cyclosporin A Metabolite 1; AM 9 (Peptide); OL 1; Cyclosporine metabolite M1; Cyclosporin metabolite AM9; Cyclosporine metabolite AM9; Cyclosporin A metabolite M1; (gamma-OH)MeLeu-9-cyclosporin; (gamma-OH)MeLeu-9-cyclosporine; (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-4-hydroxy-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-). Grades: ≥90% by HPLC. CAS No. 89270-25-7. Molecular formula: C62H111N11O13. Mole weight: 1218.61. | |
| Cyclosporin AM 9 | Cyclosporin AM 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 89270-25-7. Molecular Formula: C62H111N11O13. Mole Weight: 1218.63. Catalog: APB89270257. | |
| cyclosporin A, MeAla(6)- | cyclosporin A, MeAla(6)-. CAS No. 111710-61-3. Catalog: ACM111710613. |  |
| Cyclosporin A (Standard) | Cyclosporin A (Standard) is the analytical standard of Cyclosporin A. This product is intended for research and analytical applications. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM [3]. Cyclosporin A also inhibits CD11a/CD18 adhesion [8]. Uses: Scientific research. Group: Natural products. CAS No. 59865-13-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0579R. |  |
| Cyclosporin a sulfate | Heterocyclic Organic Compound. Alternative Names: Cyclosporin A Hydrogen Sulfate (ester). CAS No. 121673-00-5. Molecular formula: C62H111N11O15S. Mole weight: 1282.67. Purity: 0.96. Catalog: ACM121673005. | |
| Cyclosporin A sulfate | Cyclosporin A sulfate. Group: Biochemicals. Alternative Names: Cyclosporin A hydrogen sulfate (ester). Grades: Highly Purified. CAS No. 121673-00-5. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C62H111N11O15S. US Biological Life Sciences. | Worldwide |
| (1,11-seco)-Cyclosporin A Oxazolidinone Methylamide | (1,11-seco)-Cyclosporin A Oxazolidinone Methylamide, is an impurity of Cyclosporin A (C988900), which is an immunosuppressant drug widely used in organ transplantation to prevent rejection. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C65H114N12O14, Molecular Weight: 1234.60799999999. US Biological Life Sciences. | Worldwide |
| 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine]cyclosporin a | Heterocyclic Organic Compound. Alternative Names: 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A, 121584-52-9. CAS No. 121584-52-9. Molecular formula: C62H109N11O14. Mole weight: 1232.59. Appearance: White Solid. Purity: 0.96. IUPACName: [(3R,14S)-5-(dimethylamino)-3,15-dimethyl-14-[[(2S)-4-methyl-2-(methylamino)pentanoyl]amino]-1,6,13-trioxohexadecan-4-yl] acetate. Canonical SMILES: CC (C)CC (C (=O)NC (C (C)C)C (=O)CCCCCCC (=O)C (C (C (C)CC=O)OC (=O)C)N (C)C)NC. Catalog: ACM121584529. | |
| 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A | 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: (2S, 5R, 8S, 11S, 14S, 17S, 20S, 26S, 29S, 32S)-8, 11, 26, 32-Tetraisobutyl-20-ethyl-14, 29-diisopropyl-2, 5, 7, 10, 13, 16, 22, 25, 31-nonamethyl-17-[(1R, 2R)-1-acetoxy-2-methyl-4-oxobutyl]-1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31-undecaazacyclotritriacontane-3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33-undecaone; Cyclosporine EP Impurity A; Cyclosporin A, 6-[(3R,4R)-3-(acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine]-; Acetyl Cyclosporin A aldehyde. Grades: 98%. CAS No. 121584-52-9. Molecular formula: C62H109N11O14. Mole weight: 1232.59. | |
| 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A | Intermediate for the preparation of Cyclosporin derivatives for the treatment of immune disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 121584-52-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A | 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A. CAS No: 121584-52-9 |  Sarchem Laboratories New Jersey NJ |
| Acetoxy Cyclosporin A Acetate | Intermediate in the preparation of Cyclosporin A. Group: Biochemicals. Alternative Names: 6-[(3R,4R,6E)-3,8-Bis(acetyloxy)-6,7-didehydro-N,4-dimethyl-L-2-aminooctanoic acid]cyclosporin A. Grades: Highly Purified. CAS No. 138957-23-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin D, Val2 (Val2-cyclosporine (Val2)DH-CS) | The pharmacological profiles of two new derivatives of the immunosuppressive drug, cyclosporine, is presented here. (Nva2)-CS has very similar properties to CS, but lacks the nephrotoxic side-effects. This derivative appears to be a potential successor to cyclosporine. (Val2)DH-CS seems to have a different spectrum of activities. It does not suppress humoral immunity and allograft rejection, but suppresses some types of cell-mediated immune responses. This derivative may prove useful in autoimmune situations where T cells are involved in the disease process. Group: Biochemicals. Alternative Names: Val2-cyclosporine, Cyclosporin D, Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl. Grades: Highly Purified. CAS No. 63775-96-2. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C63H113N11O12, Molecular Weight: 1216.64. US Biological Life Sciences. | Worldwide |
| Cyclosporine A | Cyclosporine A. CAS No: 59865-13-3 | Sarchem Laboratories New Jersey NJ |
| Cyclosporine Impurity 3 Sodium Salt | Cyclosporine Impurity 3 Sodium Salt is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Grades: ≥90% by HPLC. Molecular formula: C7H14NO3Na. Mole weight: 183.18. | |
| Cyclosporine metabolite M17 | Cyclosporine metabolite M17 is a metabolite of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Uses: A cyclosporine metabolite specifically inhibits growth of renal cells in culture. Synonyms: Cyclosporin AM 1; 6-[(2S,3R,4R,6E)-3,8-Dihydroxy-4-methyl-2-(methylamino)-6-octenoic acid]cyclosporin A; Cyclosporin A Metabolite M17; Cyclosporin metabolite AM1; OL-17; 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, 33-[(1R,2R,4E)-1,6-dihydroxy-2-methyl-4-hexen-1-yl]-30-ethyl-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-, (3S, 6S, 9S, 12R, 15S, 18S, 21S, 24S, 30S, 33S)-. Grades: ≥90% by HPLC. CAS No. 89270-28-0. Molecular formula: C62H111N11O13. Mole weight: 1218.61. | |
| Cyclosporin L Related Compound 1 | Cyclosporin L Related Compound 1 is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: (E)-(R)-2-Methyl-hex-4-enoic acid. Grades: ≥90% by HPLC. CAS No. 93553-73-2. Molecular formula: C7H12O2. Mole weight: 128.17. | |
| Cyclosporin L Related Compound 2 | Cyclosporin L Related Compound 2 is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: (R,E)-2-methylhex-4-en-1-ol; (E)-(R)-2-Methyl-hex-4-en-1-ol; (2R,4E)-2-Methyl-4-hexen-1-ol; 4-Hexen-1-ol, 2-methyl-, (2R,4E)-. Grades: ≥90% by HPLC. CAS No. 104372-56-7. Molecular formula: C7H14O. Mole weight: 114.18. | |
| Cyclosporin L Related Compound 3 | Cyclosporin L Related Compound 3 is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: (E)-(2R,3S,4R)-2-Amino-3-hydroxy-4-methyl-oct-6-enoic acid; (2R,3S,4R,6E)-2-amino-3-hydroxy-4-methyl-6-octenoic acid; 2-Amino-4-[(2E)-2-buten-1-yl]-2,4,5-trideoxy-L-arabinonic acid; L-Arabinonic acid, 2-amino-4-[(2E)-2-buten-1-yl]-2,4,5-trideoxy-. Grades: ≥90% by HPLC. CAS No. 174292-85-4. Molecular formula: C9H17NO3. Mole weight: 187.24. | |
| Dehydro Cyclosporin A | Dehydro Cyclosporin A is a derivative of Cyclosporin A. Cyclosporin A is an impurity of cyclosporin, a calcineurin phosphatase pathway inhibitor used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: Anhydro Cyclosporin A; Anhydro Cyclosporine A; (3S,6S,9S,12R,15S,18S,21S,24S,30S,E)-30-ethyl-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-33-((R,E)-2-methylhex-4-en-1-ylidene)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone. Grades: 90%. Molecular formula: C62H109N11O11. Mole weight: 1184.59. | |
| Dihydrocyclosporin A | Dihydrocyclosporin A is a closely related co-metabolite of cyclosporin A. Dihyrocyclosporin A possesses no immuno- suppressant activity and has found use as a control to determine the role of immunosuppression in the pharmacology of cyclosporin A, particularly in the treatment of parasitic infections. Group: Biochemicals. Grades: Highly Purified. CAS No. 59865-15-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Dihydro Cyclosporin A | A Cyclosporin A analog, an immunosuppressant. Group: Biochemicals. Alternative Names: 6-[(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)octanoic acid]cyclosporin A. Grades: Highly Purified. CAS No. 59865-15-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Everolimus, Cyclosporine and Tacrolimus Mix Standard | Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Cyclosporine is an immunopsupressent thought to bind to cyclophilin in T-lymphocytes. Tacrolimus is also an immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. Molecular formula: C53H83NO14/C62H111N11O12/C44H69N. Mole weight: 958.22/1202.61/612.02. | |
| Isocyclosporin A | Cyclosporin A impurity. Group: Biochemicals. Alternative Names: (2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valine (111)-Lactone. Grades: Highly Purified. CAS No. 59865-16-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Isocyclosporin A | Isocyclosporin A is a degradation product of the immunosuppressant Cyclosporin A [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 59865-16-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129072. | |
| Iso Cyclosporin H Trifluoroacetic Acid Salt | Iso Cyclosporin H is an impurity of Cyclosporin H (C988920). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C62H111N11O12; x(C2HF3O2). US Biological Life Sciences. | Worldwide |
| Iso Cyclosporin H Trifluoroacetic Acid Salt | Iso Cyclosporin H Trifluoroacetic Acid Salt is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: (2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valine (11?1)-Lactone Trifluoroacetic Acid Salt; 10-(N-Methyl-D-valine)isocyclosporin A Trifluoroacetic Acid Salt; Cyclosporine Impurity 19 Trifluoroacetic Acid Salt; D-Valine, (2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-, (11?1)-lactone, Trifluoroacetic Acid Salt; Isocyclosporin H Trifluoroacetic Acid Salt. Grades: ≥90% by HPLC. Molecular formula: C62H111N11O12.C2HF3O2. Mole weight: 1316.63. | |
| N-Acetoxy cyclosporin A acetate | N-Acetoxy cyclosporin A acetate. Group: Biochemicals. Alternative Names: 6-[(3R,4R,6E)-3,8-Bis(acetyloxy)-6,7-didehydro-N,4-dimethyl-L-2-aminooctanoic acid]cyclosporin A. Grades: Highly Purified. CAS No. 138957-23-0. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C66H115N11O15. US Biological Life Sciences. | Worldwide |
| Tricyclic cyclosporin A | Tricyclic cyclosporin A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 153475-57-1. Molecular Formula: C64H111N11O12S. Mole Weight: 1258.72. Catalog: APB153475571. | |
| Alisporivir | Alisporivir, also known as DEB-025, a non-immunosuppressive cyclosporine A derivative, is acyclophil ininhibitor molecule with potent anti-hepatitis C virus (HCV) activity. Treatment with alisporivir alone or combined with PEGylated IFNalpha2a reduced the viral load in patients with chronic HCV infection. Synonyms: cyclo[Abu-N(Me)D-Ala-Xaa-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)]; (3S, 6S, 9S, 12R, 15S, 18S, 21S, 24S, 27R, 30S, 33S)-25, 30-diethyl-33-[(E, 1R, 2R)-1-hydroxy-2-methylhex-4-enyl]-1, 4, 7, 10, 12, 15, 19, 27, 28-nonamethyl-6, 9, 18-tris(2-methylpropyl)-3, 21, 24-tri(propan-2-yl)-1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31-undecazacyclotritriacontane-2, 5, 8, 11, 14, 17, 20, 23, 26, 29, 32-undecone; alisporivir; DEBIO-025; MeAla(3)EtVal(4)-cyclosporin; UNIL 025; UNIL-025; UNIL025. Grades: 98.15%. CAS No. 254435-95-5. Molecular formula: C63H113N11O12. Mole weight: 1216.64. | |
| AR-C117977 | AR-C117977 is a potent MCT1 inhibitor that inhibited the rat MLR and was more potent than cyclosporin A (CsA). AR-C117977 can reduce vimmune responses both in vitro and in vivo, maintains long-term graft survival, and induces operational tolerance. Synonyms: 5-((3-hydroxypropyl)thio)-1-isobutyl-3-methyl-6-(naphthalen-1-ylmethyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione; AR-C-117977; AR-C 117977. Grades: >98%. CAS No. 216685-07-3. Molecular formula: C25H28N2O3S2. Mole weight: 468.63. | |
| Chlorcyclizine hydrochloride | Chlorcyclizine is a phenylpiperazine that acts as a histamine H1 receptor antagonist (Ki = 9 nM). It is believed to be effective against hepatitis C virus (HCV; EC50 = 44 nM in vitro), targeting viral entry into host cells. Chlorcyclizine showed a synergistic effect with other hepatitis C drugs such as ribavirin, interferon, telaprevir, boceprevir, sofosbuvir, daclatasvir, and cyclosporin A. Synonyms: NSC 169496; Chlorcyclizine HCl; 1-[(4-chlorophenyl)phenylmethyl]-4-methyl-piperazine monohydrochloride. Grades: ≥98%. CAS No. 14362-31-3. Molecular formula: C18H21ClN2·HCl. Mole weight: 337.3. | |
| Cilastatin Ammonium Salt | Cilastatin Ammonium Salt is the ammonium salt of Cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Synonyms: (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid Ammonium Salt; MK-791 Ammonium Salt. Grades: > 95%. CAS No. 877674-82-3. Molecular formula: C16H29N3O5S. Mole weight: 375.48. | |
| Cilastatin sodium | Cilastatin sodium is the sodium salt of cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Synonyms: L 642957; MK 791; L642957; MK791; L-642957; MK-791; [R-[R*,S*-(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic Acid Monosodium Salt; (2Z) ?-7- [ [ (2R) ?-2-Amino-2-carboxyethyl] ?thio] ?-2- [ [ [ (1S) ?-2, ?2-dimethylcyclopropyl] ?carbonyl] ?amino] ?-2-heptenoic Acid Sodium Salt; sodium S-((Z)-6-carboxy-6-((S)-2,2-dimethylcyclopropane-1-carboxamido)hex-5-en-1-yl)-L-cysteinate. Grades: ≥99% by HPLC. CAS No. 81129-83-1. Molecular formula: C16H25N2NaO5S. Mole weight: 380.43. | |
| Cyclophilin A from Human, Recombinant | Cyclophilins are peptidyl prolyl isomerases that catalyze the cis-trans isomerization of X-Pro peptide bonds. They are highly-conserved cytoplasmic enzymes that accelerate protein folding and facilitate HIV infectivity. Cyclosporin A binds to cyclophilin and inhibits its activity. The cyclosporin A-cyclophilin complex binds to calcineurin and inhibits T-cell activation. The structure of human, recombinant cyclophilin is given by Holzman, et al. Group: Enzymes. Synonyms: PPIase; cyclophilin; peptide bond isomerase; peptidyl-prolyl cis-trans isomerase; peptidylprolyl isomerase; EC 5.2.1.8; 95076-93-0; PPIA; CYPA; CYPH; HEL-S-69p. Enzyme Commission Number: EC 5.2.1.8. CAS No. 95076-93-0. Purity: >95% (SDS-PAGE). Peptidylprolyl Isomerase. Storage: Store at -20°C. Form: Buffered aqueous solution. Source: E. coli. Species: Human. PPIase; cyclophilin; peptide bond isomerase; peptidyl-prolyl cis-trans isomerase; peptidylprolyl isomerase; EC 5.2.1.8; 95076-93-0; PPIA; CYPA; CYPH; HEL-S-69p. Cat No: NATE-0823. |  |
| Cyclosporin | Cyclosporin is a cyclic decapeptide that could be isolated form the soil fungi Tolypocladium inflatum. Cyclosporin is an immunosuppressant thought to bind to cyclophilin in T-lymphocytes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 79217-60-0. Pack Sizes: 25 mg; 50 mg. Product ID: HY-100731. | |
| Cyclosporin | It is produced by the strain of Polypocladiurn inflatum. It has a strong immunosuppressive action, but also has anti-inflammatory and weak antifungal effects. The mechanism of immunosuppression is the combination of cyclosporin A and cyclosporin-binding protein in T cells, which inhibits the activity of Calcineurin, and then impedes the transposition of intracellular transcription factors into the nucleus, and inhibits the interleukin-2 transcription, resulting in immunosuppression. It is mainly used for kidney transplantation, bone marrow and heart transplantation, and is one of the most important immunosuppressive agents in clinical application. Uses: Enzyme inhibitors. Synonyms: Restasis; Cyclosporine; Gengraf; Sandimmune; SangCyA; Atopica. Grades: >98%. CAS No. 79217-60-0. Molecular formula: C62H111N11O12. Mole weight: 1202.61. | |
| Cyclosporin B | An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Group: Biochemicals. Alternative Names: Ala2-cyclosporine; Antibiotic S 7481F2. Grades: Highly Purified. CAS No. 63775-95-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin B | Cyclosporin B is a group of nonpolar cyclic oligopeptides with immunosuppressive activity. Cyclosporin B is used for the prevention of graft rejection in organ transplantation [1]. Uses: Scientific research. Group: Peptides. CAS No. 63775-95-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1973. | |
| Cyclosporin C | A group of nonpolar cyclic oligopeptides with immunosupppressant activity. Group: Biochemicals. Alternative Names: Thr2-cyclosporine. Grades: Highly Purified. CAS No. 59787-61-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin C | Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal , antiviral, and immunosuppressant properties. Cyclosporin C is active against isolates of B. cinerea , A. niger , and Alternaria , Mucor , and Penicillium species (MICs=0.1-5 μg/ml). Uses: Scientific research. Group: Signaling pathways. CAS No. 59787-61-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N6027. | |
| Cyclosporin D | Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A [1] [2]. Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) [3]. Uses: Scientific research. Group: Peptides. CAS No. 63775-96-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W019721. | |
| Cyclosporine | Cyclosporine is an immunopsupressent thought to bind to cyclophilin in T-lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 79217-60-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C62H111N11O12, Molecular Weight: 1202.60999999999. US Biological Life Sciences. | Worldwide |
| Cyclosporin E | Cyclosporin E is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: Cyclosporin A, 5-L-valine-; Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl); 5-L-Valinecyclosporin A; (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-L-Val-). Grades: ≥90% by HPLC. CAS No. 63798-73-2. Molecular formula: C61H109N11O12. Mole weight: 1188.58. | |
| Cyclosporin E | Cyclosporin E. Uses: For analytical and research use. Group: Impurity standards. CAS No. 63798-73-2. Molecular Formula: C61H109N11O12. Mole Weight: 1188.61. Catalog: APB63798732. | |
| Cyclosporine B | Cyclosporine B. Group: Biochemicals. Alternative Names: Cyclosporin B, Ala2-cyclosporine, Antibiotic S 7481F2. Grades: Highly Purified. CAS No. 63775-95-1. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C61H109N11O12. US Biological Life Sciences. | Worldwide |
| Cyclosporine C | Cyclosporine C. Group: Biochemicals. Alternative Names: Cyclosporin C, Thr2-cyclosporine. Grades: Highly Purified. CAS No. 59787-61-0. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C62H111N11O13. US Biological Life Sciences. | Worldwide |
| Cyclosporine EP Impurity B | Cyclosporine EP Impurity B is a closely related co-metabolite of cyclosporin A. It has no immunosuppressive activity and has been used as a control to determine the role of immunosuppression in cyclosporin A pharmacology, especially in the treatment of parasitic infections. Synonyms: Dihydrocyclosporin A; 6-[(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)octanoic acid]cyclosporin A. Grades: ≥90% by HPLC. CAS No. 59865-15-5. Molecular formula: C62H113N11O12. Mole weight: 1204.62. | |
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