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| Product | Description | |
|---|---|---|
| Cyclosporine | Cyclosporine is an immunopsupressent thought to bind to cyclophilin in T-lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 79217-60-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C62H111N11O12, Molecular Weight: 1202.60999999999. US Biological Life Sciences. |  Worldwide |
| Cyclosporine A | Cyclosporine A. CAS No: 59865-13-3 |  Sarchem Laboratories New Jersey NJ |
| Cyclosporine B | Cyclosporine B. Group: Biochemicals. Alternative Names: Cyclosporin B, Ala2-cyclosporine, Antibiotic S 7481F2. Grades: Highly Purified. CAS No. 63775-95-1. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C61H109N11O12. US Biological Life Sciences. | Worldwide |
| Cyclosporine C | Cyclosporine C. Group: Biochemicals. Alternative Names: Cyclosporin C, Thr2-cyclosporine. Grades: Highly Purified. CAS No. 59787-61-0. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C62H111N11O13. US Biological Life Sciences. | Worldwide |
| Cyclosporine Impurity 1 | Cyclosporine Impurity 1 is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: (4S,5R)-5-((R,E)-hex-4-en-2-yl)-3-methyl-2-oxo-N-((4S,7S,10R,13S,16S,19S,22S,28S)-4,7,16,22-tetraisobutyl-19-isopropyl-8,10,13,17,23,26-hexamethyl-3,6,9,12,15,18,21,24,27-nonaoxo-2,5,8,11,14,17,20,23,26-nonaazatriacontan-28-yl)oxazolidine-4-carboxamide. Grade: ≥95%. Molecular formula: C57H101N11O12. Mole weight: 1132.50. |  |
| Cyclosporine Impurity 3 Sodium Salt | Cyclosporine Impurity 3 Sodium Salt is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Grade: ≥90% by HPLC. Molecular formula: C7H14NO3Na. Mole weight: 183.18. | |
| Cyclosporine metabolite M17 | Cyclosporine metabolite M17 is a metabolite of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Uses: A cyclosporine metabolite specifically inhibits growth of renal cells in culture. Synonyms: Cyclosporin AM 1; 6-[(2S,3R,4R,6E)-3,8-Dihydroxy-4-methyl-2-(methylamino)-6-octenoic acid]cyclosporin A; Cyclosporin A Metabolite M17; Cyclosporin metabolite AM1; OL-17; 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, 33-[(1R,2R,4E)-1,6-dihydroxy-2-methyl-4-hexen-1-yl]-30-ethyl-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-, (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-. Grade: ≥90% by HPLC. CAS No. 89270-28-0. Molecular formula: C62H111N11O13. Mole weight: 1218.61. | |
| Cyclosporine Resolution Mixture | This material is an approximate 100:1 (w/w) mixture of cyclosporine and cyclosporine U (USP). | |
| Cyclosporine Resolution Mixture | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. |  |
| Cyclosporin D, Val2 (Val2-cyclosporine (Val2)DH-CS) | The pharmacological profiles of two new derivatives of the immunosuppressive drug, cyclosporine, is presented here. (Nva2)-CS has very similar properties to CS, but lacks the nephrotoxic side-effects. This derivative appears to be a potential successor to cyclosporine. (Val2)DH-CS seems to have a different spectrum of activities. It does not suppress humoral immunity and allograft rejection, but suppresses some types of cell-mediated immune responses. This derivative may prove useful in autoimmune situations where T cells are involved in the disease process. Group: Biochemicals. Alternative Names: Val2-cyclosporine, Cyclosporin D, Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl. Grades: Highly Purified. CAS No. 63775-96-2. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C63H113N11O12, Molecular Weight: 1216.64. US Biological Life Sciences. | Worldwide |
| 10-[(2S)-2-Aminobutanoic acid]cyclosporin A | Cyclosporin Impurity 5 is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: Ciclosporin Impurity F; 1,11-Anhydro[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoyl-(2S)-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-(2S)-2-aminobutanoyl-N-methyl-L-leucine]; [Abu10]ciclosporin A; Cyclosporin Impurity 5; Cyclosporin A, 10-[(2S)-2-aminobutanoic acid]-; [Abu5]cyclosporin; cyclo[Abu-Sar-N(Me)Leu-Abu-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)]; cyclo[(N-(((2S)-2-aminobutyryl)-sarcosyl-N-methyl-L-leucyl)-(2S)-2-aminobutyryl)-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl]; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-21,30-Diethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3-isopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone; Ciclosporin EP Impurity F; [Abu10]cyclosporine A; Cyclosporine Abu-5 Impurity. Grade: ≥95%. CAS No. 437611-17-1. Molecular formula: C61H109N11O12. Mole weight: 1188.58. | |
| 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A | 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: (2S,5R,8S,11S,14S,17S,20S,26S,29S,32S)-8,11,26,32-Tetraisobutyl-20-ethyl-14,29-diisopropyl-2,5,7,10,13,16,22,25,31-nonamethyl-17-[(1R,2R)-1-acetoxy-2-methyl-4-oxobutyl]-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-3,6,9,12,15,18,21,24,27,30,33-undecaone; Cyclosporine EP Impurity A; Cyclosporin A, 6-[(3R,4R)-3-(acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine]-; Acetyl Cyclosporin A aldehyde. Grade: 98%. CAS No. 121584-52-9. Molecular formula: C62H109N11O14. Mole weight: 1232.59. | |
| Alisporivir | Alisporivir, also known as DEB-025, a non-immunosuppressive cyclosporine A derivative, is acyclophil ininhibitor molecule with potent anti-hepatitis C virus (HCV) activity. Treatment with alisporivir alone or combined with PEGylated IFNalpha2a reduced the viral load in patients with chronic HCV infection. Synonyms: cyclo[Abu-N(Me)D-Ala-Xaa-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)]; (3S,6S,9S,12R,15S,18S,21S,24S,27R,30S,33S)-25,30-diethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,27,28-nonamethyl-6,9,18-tris(2-methylpropyl)-3,21,24-tri(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; alisporivir; DEBIO-025; MeAla(3)EtVal(4)-cyclosporin; UNIL 025; UNIL-025; UNIL025. Grade: 98.15%. CAS No. 254435-95-5. Molecular formula: C63H113N11O12. Mole weight: 1216.64. | |
| Cyclosporin A | Cyclosporin A (Cyclosporine A) is an immunosuppressant that binds to cyclophilins, inhibiting calcineurin activity with an IC50 of 7 nM. It also inhibits CD11a/CD18 adhesion molecules. Synonyms: Ciclosporin; cyclosporine; Cyclosporine A; Sandimmun; Cyclosporin; Neoral; Ciclosporine; Sandimmune; Ramihyphin A. Grade: 98%. CAS No. 59865-13-3. Molecular formula: C62H111N11O12. Mole weight: 1202.61. | |
| Cyclosporin A | Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM[3]. Cyclosporin A also inhibits CD11a/CD18 adhesion[8]. Uses: Scientific research. Group: Natural products. Alternative Names: Cyclosporine A; Ciclosporin A; CsA. CAS No. 59865-13-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-B0579. |  |
| Cyclosporin A | Potent immunosuppressant (same as FK-506 and rapamycin). Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phos- phatase 2B (PP2B; calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells (NFAT) transcription factor, leading to disruption of T cell activation. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2). Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis). Antibacterial. Antifungal. Antiparasitic. Apoptosis inhibitor. Inhibits the mitochondrial permeability transition pore (MPTP) from opening, thus inhibiting cytochrome c release. NF-kappaB suppressor by induction of unfolded protein response (UPR). Anti-cancer compound. Apoptosis and autophagy inducer. Inhibits n Group: Biochemicals. Alternative Names: Antibiotic S 7481F1; Ciclosporin A; CsA; Cyclosporine; NSC 290193; Ramihyphin A; Sandimmun; Sandimmune; Neoral; Optimmune; Restasis; OL 27-400. Grades: Highly Purified. CAS No. 59865-13-3. Pack Sizes: 5g, 10g. US Biological Life Sciences. | Worldwide |
| Cyclosporin A-13C2,d4 Acetate | Labeled Cyclosporin A derivative. An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity. Group: Biochemicals. Alternative Names: Cyclosporine-13C2,d4 Acetate; Ciclosporin-13C2,d4 Acetate; Atopica-13C2,d4 Acetate; Sandimmun(e)-13C2,d4 Acetate; Neoral-13C2,d4 Acetate; Optimmune-13C2,d4 Acetate; Restasis-13C2,d4 Acetate. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin A-13C2,d4 (Major). | An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Group: Biochemicals. Alternative Names: Cyclosporine-13C2,d4; Ciclosporin-13C2,d4; Atopica-13C2,d4; Sandimmun(e)-13C2,d4; Neoral-13C2,d4; Optimmune-13C2,d4; Restasis-13C2,d4. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Cyclosporin A-[d4] | Cyclosporin A-[d4], is the labelled analogue of Cyclosporin A. Ciclosporin is believed to work by decreasing the function of lymphocytes. It is taken by mouth or by injection into a vein for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, and in organ transplants to prevent rejection. Synonyms: Cyclosporine-d4; Ciclosporin-d4; Atopica-d4; Cyclosporin A D4. Grade: 95% by HPLC; 95% atom D. Molecular formula: C62H107D4N11O12. Mole weight: 1206.64. | |
| Cyclosporin A-d4 (Major) | An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Group: Biochemicals. Alternative Names: Cyclosporine-d4; Ciclosporin-d4; Atopica-d4; Sandimmun(e)-d4; Neoral-d4; Optimmune-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin A-Derivative 1 | Cyclosporin A-Derivative 1 is a metabolite of cyclosporine A. Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin phosphatase. Synonyms: Leu-Val-Leu-Ala-D-Ala-Leu-Leu-Val-Aaa-Abu-Sar.BF4; (7S,10S,13S,16S,19S,22R,25S,28S,31S,34S)-10-[(1R,2R,4E)-1-Acetoxy-2-methyl-4-hexen-1-yl]-7-ethyl-16,19,28-triisobutyl-13,31-diisopropyl-N,5,11,14,17,20,22,25,29,36-decamethyl-3,6,9,12,15,18,21,24,27,3 0,33-undecaoxo-2-oxa-5,8,11,14,17,20,23,26,29,32-decaazaheptatriacontan-34-aminium tetrafluoroborate. Grade: ≥98%. CAS No. 1487360-85-9. Molecular formula: C65H118BF4N11O14. Mole weight: 1364.50. | |
| Cyclosporin AM 1 | A cyclosporine metabolite specifically inhibits growth of renal cells in culture. Group: Biochemicals. Alternative Names: 6-[(2S,3R,4R,6E)-3,8-Dihydroxy-4-methyl-2-(methylamino)-6-octenoic acid]cyclosporin A; Cyclosporin A Metabolite 17; Cyclosporin Metabolite 17; M 17; OL 17. Grades: Highly Purified. CAS No. 89270-28-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin AM 9 | Cyclosporin AM 9 is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: (4-Hydroxy-N-methyl-L-leucine)cyclosporine; 3-(4-Hydroxy-N-methyl-L-leucine)cyclosporin A; Cyclosporin A Metabolite 1; AM 9 (Peptide); OL 1; Cyclosporine metabolite M1; Cyclosporin metabolite AM9; Cyclosporine metabolite AM9; Cyclosporin A metabolite M1; (gamma-OH)MeLeu-9-cyclosporin; (gamma-OH)MeLeu-9-cyclosporine; (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-4-hydroxy-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-). Grade: ≥90% by HPLC. CAS No. 89270-25-7. Molecular formula: C62H111N11O13. Mole weight: 1218.61. | |
| Cyclosporin A (Standard) | Cyclosporin A (Standard) is the analytical standard of Cyclosporin A. This product is intended for research and analytical applications. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM [3]. Cyclosporin A also inhibits CD11a/CD18 adhesion [8]. Uses: Scientific research. Group: Natural products. CAS No. 59865-13-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0579R. | |
| Cyclosporin A Sulfate | Cyclosporin A Sulfate is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Uses: A metabolite of cyclosporin a. Synonyms: Cyclosporin A Hydrogen Sulfate (ester); Cyclosporine Sulfate; (1R,2R,4E)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-2-methyl-4-hexen-1-yl hydrogen sulfate. Grade: 95%. CAS No. 121673-00-5. Molecular formula: C62H111N11O15S. Mole weight: 1282.67. | |
| Cyclosporin B | An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Group: Biochemicals. Alternative Names: Ala2-cyclosporine; Antibiotic S 7481F2. Grades: Highly Purified. CAS No. 63775-95-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin B | Cyclosporin B is a minor analogue of the cyclosporin complex produced by Trichoderma. An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Synonyms: 7-L-Alaninecyclosporine A. Grade: ≥90% by HPLC. CAS No. 63775-95-1. Molecular formula: C61H109N11O12. Mole weight: 1188.58. | |
| Cyclosporin C | A group of nonpolar cyclic oligopeptides with immunosupppressant activity. Group: Biochemicals. Alternative Names: Thr2-cyclosporine. Grades: Highly Purified. CAS No. 59787-61-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin d | Cyclosporin d. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CYCLOSPORIN D;Val2-cyclosporine;(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Val-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-);(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Val-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-);Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl];7-L-Valinecyclosporin A;Cyclosporine IMpurity-D;7-L-valinecyclosporine A. Product Category: Heterocyclic Organic Compound. CAS No. 63775-96-2. Molecular formula: C63H111N11O12. Mole weight: 1214.62. Product ID: ACM63775962. Alfa Chemistry ISO 9001:2015 Certified. Categories: Cyclosporin (disambiguation). |  |
| Cyclosporin D | Cyclosporin D is a group of nonpolar cyclic oligopeptides with immunosupppressant activity. Cyclosporin D is a minor analogue of the cyclosporin complex produced by Trichoderma. Synonyms: Ciclosporin Impurity G; 1,11-Anhydro[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]; [Val7]ciclosporin A; Ciclosporin D; Val2-cyclosporine; 7-L-Valinecyclosporin A; Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]; Cyclosporine D; cyclo[Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)-Val-Sar-N(Me)Leu-Val-N(Me)Leu]. Grade: ≥90% by HPLC. CAS No. 63775-96-2. Molecular formula: C63H113N11O12. Mole weight: 1216.64. | |
| Cyclosporin H | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopybuilding blocks. Alternative Names: Cyclosporin H, Sandoz 37-839, 5-(N-Methyl-D-valine)-cyclosporin A, 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane, cyclic peptide deriv., Cyclosporine H,Ciclosporin H, Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]. | |
| Cyclosporin H | The minor analogues of the cyclosporin family have immunological activity because they do not bind to immunophilins. It is an inhibitor of phorbol ester that effectively promotes tumors on mouse skin, and effectively inhibits calcium/calmodulin-dependent phosphorylation of EF-2 in vitro. It is an effective and selective formyl peptide receptor antagonist and formyl peptide-induced superoxide formation inhibitor. Synonyms: 5-(N-methyl-D-valine)cyclosporine A. Grade: 95%. CAS No. 83602-39-5. Molecular formula: C62H111N11O12. Mole weight: 1202.61. | |
| Cyclosporin U | Cyclosporin U is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: Ciclosporin Impurity D; 1,11-Anhydro[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoyl-(2S)-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-L-leucine]; [Leu11]Ciclosporin A; Ciclosporin U; Ciclosporin EP Impurity D; 11-L-Leucine-Cyclosporin A; Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-L-leucyl); 11-L-Leucinecyclosporin A; Cyclosporine EP Impurity D; Cyclo[[(E)-(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoyl]-L-2-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl]. Grade: 95%. CAS No. 108027-45-8. Molecular formula: C61H109N11O12. Mole weight: 1188.61. | |
| Cyclosporin V | Cyclosporin V is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: Ciclosporin Impurity E; 1,11-Anhydro[D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoyl-(2S)-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-(2S)-2-aminobutanoic acid]; [Abu1]Ciclosporin A; Ciclosporin V; Cyclosporine V; Ciclosporin EP Impurity E; Cyclosporin A, 1-[(2S)-2-aminobutanoic acid]-; 1-[(2S)-2-Aminobutanoic acid]cyclosporin A; cyclo[Abu-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)-Abu-Sar-N(Me)Leu-Val-N(Me)Leu]; cyclo[(N-(((2S)-2-aminobutyryl)-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl)-(2S)-2-aminobutyryl)-sarcosyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]; 1-(L-2-Aminobutanoic acid)cyclosporin A; Cyclo[D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-2-aminobutanoyl]. Grade: ≥90% by HPLC. CAS No. 108027-46-9. Molecular formula: C63H113N11O12. Mole weight: 1216.63. | |
| Dehydro Cyclosporin A | Dehydro Cyclosporin A is a derivative of Cyclosporin A. Cyclosporin A is an impurity of cyclosporin, a calcineurin phosphatase pathway inhibitor used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: Anhydro Cyclosporin A; Anhydro Cyclosporine A; (3S,6S,9S,12R,15S,18S,21S,24S,30S,E)-30-ethyl-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-33-((R,E)-2-methylhex-4-en-1-ylidene)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone. Grade: 90%. Molecular formula: C62H109N11O11. Mole weight: 1184.59. | |
| Dehydro Cyclosporin A-[d4] | An isotope labelled derivative of Ciclosporin A. Ciclosporin is an immunosuppressant medication. Synonyms: Dehydro Cyclosporin A-D4; Anhydro Cyclosporine A-d4. Grade: 95% by HPLC; 98% atom D. Molecular formula: C62H105D4N11O11. Mole weight: 1188.62. | |
| Dihydrocyclosporin A | An impurity of Cyclosporine. Cyclosporine is a powerful immunosuppressive medication derived from a fungal source. It is primarily used to prevent organ rejection in transplant recipients by inhibiting the activation of T-cells, a key component of the immune system. Cyclosporine is also used to treat certain autoimmune diseases, such as psoriasis and rheumatoid arthritis, where the immune system mistakenly attacks the bodys own tissues. Synonyms: Ciclosporin Impurity B; 1,11-Anhydro[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)octanoyl-(2S)-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]; Dihydrociclosporin A; 6-[(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)octanoic acid]cyclosporin A; 6-[(3R,4R)-3-Hydroxy-N,4-dimethyl-L-2-aminooctanoic acid]cyclosporin A; Dihydro Cyclosporin A; Dihydrocyclosporine A; Cyclosporin A Dihydro Impurity; Cyclosporine EP Impurity B; Ciclosporin EP Impurity B. Grade: ≥90% by HPLC. CAS No. 59865-15-5. Molecular formula: C62H113N11O12. Mole weight: 1204.62. | |
| Dihydrocyclosporin H | Dihydrocyclosporin H is a remarkable immunosuppressant extensively employed in the dynamic biomedical research, used for studying diverse autoimmune maladies, transplant rejections and organ transplantations. Synonyms: Dihydrocyclosporin A; DIHYDROCYCLOSPORINH; 83602-88-4; Dihydro Cyclosporin A; Dihydrocyclosporin; 59865-15-5; Dihydrocyclosporin H; Dihydrocyclosporine H; SCHEMBL13985556; BCP14498; FT-0666927; 30-ethyl-33-(1-hydroxy-2-methylhexyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone. Grade: HPLC>95%. CAS No. 83602-88-4. Molecular formula: C62H111N11O12. Mole weight: 1204.6. | |
| Geclosporin | Geclosporin is an impurity of cycloporine, which is an immunosuppressant used in the treatment of rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, etc. Uses: Immunosuppressant. Synonyms: Cyclosporin G; Cyclosporine G. Grade: ≥90% by HPLC. CAS No. 74436-00-3. Molecular formula: C63H113N11O12. Mole weight: 1216.662. | |
| Isocyclosporin A | A rearranged degradation product formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions. Synonyms: Ciclosporin Impurity C; O3.1,11-Anhydro[(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoyl-(2S)-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valine]; Isociclosporin A; Cyclosporine EP Impurity C; Iso Cyclosporin A; Ciclosporin EP Impurity C; (2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valine (11→1)-Lactone; Iso Cyclosporine A; Cyclo[L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-[(3R,4R)-3-hydroxy-N-methyl-5-[(E)-1-propenyl]-L-Leu-]]; [2S-(2R*,3S*,4S*,6E)]-N-[3-Hydroxy-4-methyl-2-(methylamino)-1-oxo-6-octenyl]-L-α-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valine θ1-lactone. Grade: ≥90% by HPLC. CAS No. 59865-16-6. Molecular formula: C62H111N11O12. Mole weight: 1202.61. | |
| Iso Cyclosporin H Trifluoroacetic Acid Salt | Iso Cyclosporin H Trifluoroacetic Acid Salt is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: (2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valine (11→1)-Lactone Trifluoroacetic Acid Salt; 10-(N-Methyl-D-valine)isocyclosporin A Trifluoroacetic Acid Salt; Cyclosporine Impurity 19 Trifluoroacetic Acid Salt; D-Valine, (2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-, (11→1)-lactone, Trifluoroacetic Acid Salt; Isocyclosporin H Trifluoroacetic Acid Salt. Grade: ≥90% by HPLC. Molecular formula: C62H111N11O12.C2HF3O2. Mole weight: 1316.63. | |
| Ketoconazole | Ketoconazole inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. It is used primarily to treat fungal infections. Uses: For the treatment of fungal infections. Synonyms: Kuric; Nizoral; (2R,4S)-ketoconazole; Fungarest. Grade: >98%. CAS No. 65277-42-1. Molecular formula: C26H28Cl2N4O4. Mole weight: 531.43. | |
| NFAT Inhibitor, MCV1 (MPB-HPVIVIT, Maleimido-conjugated HPVIVIT, Maleimido-conjugated VIVIT 1) | A cell-permeable, synthetic maleimido-conjugated VIVIT motif peptide (HPVIVIT) that acts as a potent bipartite inhibitor of Nuclear factor of activated T-cells (NFAT) (IC50=62nM). Blocks NFAT-calcineurin interaction by targeting two separate calcineurin docking motifs. Completely blocks NFAT dephosphorylation at 1mM. Determined to be more potent that Cyclosporine A and VIVIT peptide (MAGPHPVIVITGPHEE) in blocking NFAT activity. Also shown to blocks NFAT-mediated T-cell activation and vascular smooth muscle cell proliferation, thereby reducing neoimtima (new thickening of arterial wall) formation in mouse models of restenosis (repeat blocking of blood vessels). The biological half life of MCV1 has been estimated to be about 36 hours in COS-1 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??N??O??. US Biological Life Sciences. | Worldwide |
| (1,11-seco)-Cyclosporin A Oxazolidinone Methylamide | (1,11-seco)-Cyclosporin A Oxazolidinone Methylamide, is an impurity of Cyclosporin A (C988900), which is an immunosuppressant drug widely used in organ transplantation to prevent rejection. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C65H114N12O14, Molecular Weight: 1234.60799999999. US Biological Life Sciences. | Worldwide |
| 1,3-Dimethyl-5-(2-methyl-4-hexenylidene)-2-thioxo-4-imidazolidinone | 1,3-Dimethyl-5-(2-methyl-4-hexenylidene)-2-thioxo-4-imidazolidinone is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: 4-Imidazolidinone, 1,3-dimethyl-5-(2-methyl-4-hexen-1-ylidene)-2-thioxo-; 1,3-Dimethyl-5-(2-methyl-4-hexen-1-ylidene)-2-thioxo-4-imidazolidinone; 4-Imidazolidinone, 1,3-dimethyl-5-(2-methyl-4-hexenylidene)-2-thioxo-. CAS No. 59865-22-4. Molecular formula: C12H18N2OS. Mole weight: 238.35. | |
| [2R-[2α(S*),3β,5β]]-5-Ethyltetrahydro-3-methyl-α-(methylamino)-2-furanacetic Acid | [2R-[2α(S*),3β,5β]]-5-Ethyltetrahydro-3-methyl-α-(methylamino)-2-furanacetic Acid is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: 2-Furanacetic acid, 5-ethyltetrahydro-3-methyl-α-(methylamino)-, [2R-[2α(S*),3β,5β]]-. CAS No. 127605-69-0. Molecular formula: C10H19NO3. Mole weight: 201.26. | |
| (3S,6S,9S,12R,18S,21S,24S,30S)-15,21,30-triethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3-isopropyl-1,4,7,10,12,19,25,28-octamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone | An impurity of cyclosporin. Cyclosporin is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Molecular formula: C62H111N11O12. Mole weight: 1202.64. | |
| 4-[2-(Dimethylamino)ethoxy]benzaldehyde | 4-[2-(Dimethylamino)ethoxy]benzaldehyde is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: p-[2-(Dimethylamino)ethoxy]benzaldehyde; 4-(N,N-dimethylaminoethoxy)benzaldehyde; 4-(2-dimethylamino-1-ethoxy)benzaldehyde; Benzaldehyde, 4-[2-(dimethylamino)ethoxy]-. Grade: ≥95%. CAS No. 15182-92-0. Molecular formula: C11H15NO2. Mole weight: 193.24. | |
| 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine]cyclosporin a | 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine]cyclosporin a. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A, 121584-52-9. Product Category: Heterocyclic Organic Compound. Appearance: White Solid. CAS No. 121584-52-9. Molecular formula: C62H109N11O14. Mole weight: 1232.59. Purity: 0.96. IUPACName: [(3R,14S)-5-(dimethylamino)-3,15-dimethyl-14-[[(2S)-4-methyl-2-(methylamino)pentanoyl]amino]-1,6,13-trioxohexadecan-4-yl] acetate. Canonical SMILES: CC(C)CC(C(=O)NC(C(C)C)C(=O)CCCCCCC(=O)C(C(C(C)CC=O)OC(=O)C)N(C)C)NC. Product ID: ACM121584529. Alfa Chemistry ISO 9001:2015 Certified. | |
| 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A | Intermediate for the preparation of Cyclosporin derivatives for the treatment of immune disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 121584-52-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A | 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A. CAS No: 121584-52-9 | Sarchem Laboratories New Jersey NJ |
| 9-(N-Methyl-L-valine)cyclosporin A | 9-(N-methyl-L-valine)cyclosporin A is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane, cyclic peptide deriv.; N-Methyl-valyl-4-cyclosporin A; N-Methyl-Val-4-CsA; SDZ 220-384; cyclo[Abu-Sar-N(Me)Val-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)]; cyclo[((2S)-2-aminobutyryl)-sarcosyl-N-methyl-L-valyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl]; Cyclosporin A, 9-(N-methyl-L-valine)-. CAS No. 156047-28-8. Molecular formula: C61H109N11O12. Mole weight: 1188.58. | |
| Acetoxy Cyclosporin A Acetate | Intermediate in the preparation of Cyclosporin A. Group: Biochemicals. Alternative Names: 6-[(3R,4R,6E)-3,8-Bis(acetyloxy)-6,7-didehydro-N,4-dimethyl-L-2-aminooctanoic acid]cyclosporin A. Grades: Highly Purified. CAS No. 138957-23-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| AR-C117977 | AR-C117977 is a potent MCT1 inhibitor that inhibited the rat MLR and was more potent than cyclosporin A (CsA). AR-C117977 can reduce vimmune responses both in vitro and in vivo, maintains long-term graft survival, and induces operational tolerance. Synonyms: 5-((3-hydroxypropyl)thio)-1-isobutyl-3-methyl-6-(naphthalen-1-ylmethyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione; AR-C-117977; AR-C 117977. Grade: >98%. CAS No. 216685-07-3. Molecular formula: C25H28N2O3S2. Mole weight: 468.63. | |
| Cilastatin Ammonium Salt | Cilastatin Ammonium Salt is the ammonium salt of Cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Synonyms: (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid Ammonium Salt; MK-791 Ammonium Salt. Grade: > 95%. CAS No. 877674-82-3. Molecular formula: C16H29N3O5S. Mole weight: 375.48. | |
| Cilastatin sodium | Cilastatin sodium is the sodium salt of cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Synonyms: L 642957; MK 791; L642957; MK791; L-642957; MK-791; [R-[R*,S*-(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic Acid Monosodium Salt; (2Z)?-7-[[(2R)?-2-Amino-2-carboxyethyl]?thio]?-2-[[[(1S)?-2,?2-dimethylcyclopropyl]?carbonyl]?amino]?-2-heptenoic Acid Sodium Salt; sodium S-((Z)-6-carboxy-6-((S)-2,2-dimethylcyclopropane-1-carboxamido)hex-5-en-1-yl)-L-cysteinate. Grade: 98%. CAS No. 81129-83-1. Molecular formula: C16H25N2NaO5S. Mole weight: 380.43. | |
| Cyclophilin A from Human, Recombinant | Cyclophilins are peptidyl prolyl isomerases that catalyze the cis-trans isomerization of X-Pro peptide bonds. They are highly-conserved cytoplasmic enzymes that accelerate protein folding and facilitate HIV infectivity. Cyclosporin A binds to cyclophilin and inhibits its activity. The cyclosporin A-cyclophilin complex binds to calcineurin and inhibits T-cell activation. The structure of human, recombinant cyclophilin is given by Holzman, et al. Group: Enzymes. Synonyms: PPIase; cyclophilin; peptide bond isomerase; peptidyl-prolyl cis-trans isomerase; peptidylprolyl isomerase; EC 5.2.1.8; 95076-93-0; PPIA; CYPA; CYPH; HEL-S-69p. Enzyme Commission Number: EC 5.2.1.8. CAS No. 95076-93-0. Purity: >95% (SDS-PAGE). Peptidylprolyl Isomerase. Storage: Store at -20°C. Form: Buffered aqueous solution. Source: E. coli. Species: Human. PPIase; cyclophilin; peptide bond isomerase; peptidyl-prolyl cis-trans isomerase; peptidylprolyl isomerase; EC 5.2.1.8; 95076-93-0; PPIA; CYPA; CYPH; HEL-S-69p. Cat No: NATE-0823. |  |
| Cyclosporin | Cyclosporin is a cyclic decapeptide that could be isolated form the soil fungi Tolypocladium inflatum. Cyclosporin is an immunosuppressant thought to bind to cyclophilin in T-lymphocytes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 79217-60-0. Pack Sizes: 25 mg; 50 mg. Product ID: HY-100731. | |
| Cyclosporin | It is produced by the strain of Polypocladiurn inflatum. It has a strong immunosuppressive action, but also has anti-inflammatory and weak antifungal effects. The mechanism of immunosuppression is the combination of cyclosporin A and cyclosporin-binding protein in T cells, which inhibits the activity of Calcineurin, and then impedes the transposition of intracellular transcription factors into the nucleus, and inhibits the interleukin-2 transcription, resulting in immunosuppression. It is mainly used for kidney transplantation, bone marrow and heart transplantation, and is one of the most important immunosuppressive agents in clinical application. Uses: Enzyme inhibitors. Synonyms: Cyclosporins. Grade: >98%. CAS No. 79217-60-0. | |
| Cyclosporin A | 100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C62H111N11O12. CAS No. 59865-13-3. Prepack ID 40007313-100mg. Molecular Weight 1202.61. See USA prepack pricing. |  |
| Cyclosporin A | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C62H111N11O12. CAS No. 59865-13-3. Prepack ID 40007313-1g. Molecular Weight 1202.61. See USA prepack pricing. | |
| Cyclosporin A 8-N-MeAla | Cyclosporin A 8-N-MeAla. Uses: For analytical and research use. Group: Impurity standards. CAS No. 108466-41-7. Molecular formula: C63H113N11O12. Mole weight: 1216.66. Catalog: APB108466417. | |
| Cyclosporin A, 9-(4-hydroxy-N-methyl-L-leucine)- | Cyclosporin A, 9-(4-hydroxy-N-methyl-L-leucine)- is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: Cyclosporin Impurity 19. CAS No. 107335-26-2. Molecular formula: C62H111N11O13. Mole weight: 1218.63. | |
| Cyclosporin A Acetate | A non-immunosuppressive analog. Group: Biochemicals. Alternative Names: 6-[(2S,3R,4R,6E)-3-(Acetyloxy)-4-methyl-2-(methylamino)-6-octenoic acid] Cyclosporin A; B 3-243; O-Acetyl-C91-cyclosporin A; O-Acetylcyclosporin A; SDZ 33-243. Grades: Highly Purified. CAS No. 83602-41-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin A-[d4] Acetate | Cyclosporin A-[d4] Acetate is a labelled analogue of Cyclosporin A. Ciclosporin is an immunosuppressant medication. Synonyms: Cyclosporin A-D4 Acetate. Grade: 95% by HPLC; 98% atom D. Molecular formula: C64H109D4N11O13. Mole weight: 1248.67. | |
| Cyclosporin A-d4 Acetate (Major) | A non-immunosuppressive analog. Group: Biochemicals. Alternative Names: 6-[(2S,3R,4R,6E)-3-(Acetyloxy)-4-methyl-2-(methylamino)-6-octenoic-d4 acid] Cyclosporin A; B 3-243-d4; O-Acetyl-C91-cyclosporin A-d4; O-Acetylcyclosporin A-d4; SDZ 33-243-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cyclosporin A-Derivative 1 Free base | Cyclosporin A-Derivative 1 Free base is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: Cyclosporin A open ring; N-Methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methyl-glycine Methyl Ester; Cyclosporin A-Derivative 1 (Free base); Cyclosporin A seco(MeGly-MeLeu) Methyl Ester; Leu-Val-Leu-Ala-{d-Ala}-Leu-Leu-Val-{Aaa}-{Abu}-{Sar}; LVLA-{d-Ala}-LLV-{Aaa}-{Abu}-{Sar}. Grade: ≥95%. CAS No. 286852-20-8. Molecular formula: C65H117N11O14. Mole weight: 1276.69. | |
| Cyclosporin A-Derivative 2 | Cyclosporin A-Derivative 2 is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: L-Valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methyl-glycine Methyl Ester; Des(N-Methyl-leucyl) Cyclosporin A seco(MeGly-MeLeu) Methyl Ester; Glycine, L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methyl-, methyl ester. Grade: ≥95%. CAS No. 156047-45-9. Molecular formula: C58H104N10O13. Mole weight: 1149.51. | |
| Cyclosporin AM 3 | Cyclosporin AM 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 153049-50-4. Molecular formula: C62H111N11O13. Mole weight: 1218.63. Catalog: APB153049504. | |
| Cyclosporin AM 4N | Cyclosporin AM 4N is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: 9-L-Leucinecyclosporin A; 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane Cyclic Peptide Deriv; AM 4N; Cyclosporin A Metabolite 21; M 21; OL 21; [Leu4]cyclosporin. Grade: ≥90% by HPLC. CAS No. 89270-23-5. Molecular formula: C61H109N11O12. Mole weight: 1188.58. | |
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