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| Product | Description | |
|---|---|---|
| Cysteine Protease inhibitor | Cysteine Protease inhibitor is a inhibitor of cysteine protease. Synonyms: 2-Pyrimidinecarbonitrile, 4-[[4'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-. Grades: >98%. CAS No. 921625-62-9. Molecular formula: C18H14N4O. Mole weight: 302.33. |  |
| Cysteine Protease inhibitor | Cysteine Protease inhibitor is an inhibitor of cysteine protease. Uses: Scientific research. Group: Signaling pathways. CAS No. 921625-62-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17541. |  |
| Cysteine Protease inhibitor hydrochloride | Cysteine Protease inhibitor hydrochloride is an inhibitor of cysteine protease. Uses: Scientific research. Group: Signaling pathways. CAS No. 2197053-49-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17541A. | |
| 1, ?2-?Piperidinedicarboxyl ?ic Acid 1-?(Phenylmethyl) Ester | 1, ?2-?Piperidinedicarboxyl ?ic Acid 1-?(Phenylmethyl) Ester is used to prepare disubstituted azetidinones as selective inhibitors of cysteine protease cathepsin K. It is also used to synthesize 2-?[(R)?-?2-?methylpyrrolidin-?2-?yl]?-?1H-?benzimidazole-?4-?carboxamide (ABT-?888) as the Poly(ADP-?ribose) Polymerase (PARP) inhibitor for the treatment of cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 28697-07-6. Pack Sizes: 25g, 100g. Molecular Formula: C14H17NO4, Molecular Weight: 263.29. US Biological Life Sciences. |  Worldwide |
| 1,3-Bis-(Z-Leu-Leu)-diaminoacetone | 1,3-Bis-(Z-Leu-Leu)-diaminoacetone, a cysteine protease inhibitor, can specifically and efficiently inhibit the processing of p-Prl signal peptide (IC50 ca. 50 nM) without affecting the activity of signal peptidase and lysosomal cathepsin, proteasome, and other proteases. Synonyms: (Z-LL)2 Ketone; Z-Leu-Leu-NH-CH2-CO-CH2-NH-Leu-Leu-Z; 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide; 1,3-di-(N-carboxybenzoyl-leucyl-leucyl)aminoacetone; Dibenzyl [(4S,7S,15S,18S)-7,15-diisobutyl-2,20-dimethyl-5,8,11,14,17-pentaoxo-6,9,13,16-tetraazahenicosane-4,18-diyl]biscarbamate. Grades: ≥95%. CAS No. 313664-40-3. Molecular formula: C43H64N6O9. Mole weight: 809.00. | |
| [1- (4-Bromophenyl) cyclopropyl]methanol | Used for preparation of amino acid derivatives as cathepsin cysteine protease inhibitors. Group: Biochemicals. Alternative Names: 1-(4-Bromophenyl)-1-cyclopropanemethanol; 1- (p-Bromophenyl) cyclopropanemethanol. Grades: Highly Purified. CAS No. 98480-31-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 1-Dodecylimidazole | 1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-DODECYLIMIDAZOLE;1-DODECYL-1H-IMIDAZOLE;1-dodecyl-1h-imidazol;1-dodecyl-imidazol;1-laurylimidazole;n-laurylimidazole;N-DODECYLIMIDAZOLE;1-Dodecylimidazole,95%. Product Category: Inhibitors. Appearance: Clourless Liquid. CAS No. 4303-67-7. Molecular formula: C15H28N2. Mole weight: 236.4. Purity: 0.98. IUPACName: 1-dodecylimidazole. Canonical SMILES: CCCCCCCCCCCCN1C=CN=C1. ECNumber: 224-314-4. Product ID: ACM4303677. Alfa Chemistry ISO 9001:2015 Certified. |  |
| (2E)-5-Hydroxy-2-pentenoic Acid Methyl Ester | (2E)-5-Hydroxy-2-pentenoic Acid Methyl Ester is an intermediate in the preparation of unusual amino acids that are potential Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors. Group: Biochemicals. Alternative Names: (E)-5-Hydroxy-2-pentenoic Acid Methyl Ester. Grades: Highly Purified. CAS No. 62592-80-7. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 2-Pyrimidinecarbonitrile | Cathepsin K is a lysosomal cysteine protease found in osteoclasts whose elevated activity has been linked to the formation of osteoporosis and arthritis. 2-cyano-Pyrimidine is a cathepsin K inhibitor. Synonyms: pyrimidine-2-carbonitrile. Grades: 95+%. CAS No. 14080-23-0. Molecular formula: C5H3N3. Mole weight: 105.10. | |
| 3-Amino-1,4-dimethylpyrazole | 3-Amino-1,4-dimethylpyrazole is used in the preparation of peptides as cysteine protease inhibitors. Group: Biochemicals. Alternative Names: 1,4-Dimethyl-1H-pyrazol-3-amine. Grades: Highly Purified. CAS No. 85485-61-6. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Adenovirus Proteinase Inhibitor, NSC 37249 (2- (Dicyclohexylamino) -N- (4- (4- ( (2- (dicyclohexylamino) acetyl) amino) phenyl) sulfonylphenyl) acetamide, N, N?- (Sulfonyldi-4, 1-phenylene) bis (2- (dicyclohexylamino) acetamide, AVP Inhibitor) | A sulfonyl diphenyl ene -bis-dicyclohexyl aminoacetamide compound that acts as a potent and selective inhibitor against adenovirus cysteine proteinase AVP by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (Ki = 150nM) and AVP-pVIc substrate-binding site (Ki = 400nM), blocking both AVP-pVIc active complex formation (IC50 = 140nM; [substrate] = 5uM & [pVIc] = 40uM) and catalytic activity (IC50 = 490nM; [substrate] = 5uM) without affecting trypsin or papain protease activity even at concentrations as high as 10uM. Group: Biochemicals. Grades: Purified. CAS No. 2907-88-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| Aloxistatin (E-64d) | Aloxistatin (E-64d), is a selective cysteine protease inhibitor or calpain and autophagy inhibitor. E-64d prevents in vitro cerulein- induced trypsinogen activation. E-64d can enter the intact cell and inhibit calpain. E-64d has been shown safe for the treatment of Alzheimer's disease in human. E-64d is potentially useful in the treatment of developmental seizure-induced brain damage both by regulating abnormal zinc signal transduction and through the modulation of altered lipid metabolism via ApoE/clusterin pathway in hippocampus. Uses: Designed for use in research and industrial production. Additional or Alternative Names: E-64d; E 64d; E64d; E64-d; E64-d; E64 d; ethyl ester Loxistatin; NSC 694281; NSC694281; NSC-694281; EST; EP-453; EP453; EP 453; Aloxistatin. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 88321-09-9. Molecular formula: C17H30N2O5. Mole weight: 342.44. Purity: >98%. IUPACName: ethyl (2S,3S)-3-(((S)-1-(isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylate. Canonical SMILES: CCOC([C@@H]1[C@@H](C(N[C@H](C(NCCC(C)C)=O)CC(C)C)=O)O1)=O. Product ID: ACM88321099. Alfa Chemistry ISO 9001:2015 Certified. | |
| Calpain Inhibitor VI | Calpain Inhibitor VI is a cell-permeable peptide aldehyde which functions as a reversible calpain inhibitor. It is an inhibitor of the calcium-dependent cysteine proteases μ-calpain with IC50 of 7.5 nM for calpain-1 and m-calpain with IC50 of 78 nM for calpain-2. Calpain Inhibitor VI can reduce nuclear opacity and proteolysis of crystallins and α-spectrin. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Synonyms: SJA 6017. Grades: ≥95%. CAS No. 190274-53-4. Molecular formula: C17H25FN2O4S. Mole weight: 372.5. | |
| Caspase-7 from Human, Recombinant | Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing by upstream caspases (caspase-8, -9) at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme in the form of a heterotetramer. The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms. Applications: Used to screen caspase inhibitors, study enzyme regulation, determine caspase substrate specificity, or as positive control in caspase activity assays. Group: Enzymes. Synonyms: CASP7; CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3; Caspase-7. Enzyme Commission Number: EC 3.4.22.-. Purity: 90% (SDS-PAGE). Caspase 7. Activity: ~25,000U/mg protein. Appearance: Lyophilized. Storage: -80°C. Source: E. coli. Species: Human. CASP7; CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3; Caspase-7. Cat No: NATE-0815. |  |
| (E)-4-Hydroxycrotonoic Acid Ethyl Ester | (E)-4-Hydroxycrotonoic Acid Ethyl Ester is an intermediate in the preparation of unusual amino acids that are potential Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors. Group: Biochemicals. Alternative Names: Ethyl trans-4-Hydroxy-2-butenoate; (2E)-4-Hydroxy-2-butenoic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 10080-68-9. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| (E)-4-Hydroxycrotonoic Acid Ethyl Ester | (E)-4-Hydroxycrotonoic Acid Ethyl Ester is an intermediate used to prepare unusual amino acids that are potential Michael acceptor-based anti-plasmodium and anti-trypanosomal cysteine protease inhibitors. Synonyms: Ethyl trans-4-Hydroxy-2-butenoate; (2E)-4-Hydroxy-2-butenoic Acid Ethyl Ester; 2-Butenoic acid, 4-hydroxy-, ethyl ester, (2E)-. Grades: 95%. CAS No. 10080-68-9. Molecular formula: C6H10O3. Mole weight: 130.14. | |
| E-64 | E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain. Uses: For research used only. Synonyms: L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide; Proteinase inhibitor E 64; 3-[[[ (1S) -1-[[[4-[ (aminoiminomethyl) amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]- (2S, 3S) -oxiranecarboxylic acid; Thiol protease inhibitor; trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane; 2-Oxiranecarboxylic acid, 3-[[[ (1S) -1-[[[4-[ (aminoiminomethyl) amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-; L-Trans-Epoxysuccinyl-Leu-agmatine. Grades: ≥99% by HPLC. CAS No. 66701-25-5. Molecular formula: C15H27N5O5. Mole weight: 357.41. | |
| E-64 | E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general cysteine proteases with IC 50 of 9 nM for papain. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Proteinase inhibitor E 64. CAS No. 66701-25-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15282. | |
| EST - CAS 88321-09-9 | A cell-permeable, irreversible inhibitor of cysteine proteases. Group: Fluorescence/luminescence spectroscopy. |  |
| Fumaric Acid tert-Butyl Ester | Fumaric Acid tert-Butyl Ester is a tert-Butyl ester derivative of Fumaric Acid (F500380). Fumaric Acid tert-Butyl Ester is a reactant used in the preparation of cysteine protease inhibitors based on fumaric acid-derived oligopeptides. It is also used in the preparation of Nε-fumaroylated diketopiperazine of L-Lys used for pulmonary drug delivery. Group: Biochemicals. Alternative Names: (2E)-2-Butenedioic Acid Mono(1,1-dimethylethyl) Ester; (E)-4-tert-Butoxy-4-oxobut-2-enoic Acid. Grades: Highly Purified. CAS No. 135355-96-3. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| H-D-allo-Threonine Methyl Ester Hydrochloride | H-D-allo-Threonine Methyl Ester Hydrochloride is used to prepare hepatitis A virus 3C cysteine protease inhibitors. Synonyms: H-D-allo-Thr-OMe HCl; (2R,3R)-Methyl 2-Amino-3-hydroxybutanoate Hydrochloride; Methyl D-allo-Threoninate Hydrochloride. Grades: ≥95%. CAS No. 60538-18-3. Molecular formula: C5H12ClNO3. Mole weight: 169.61. | |
| HRV3C Protease from human, Recombinant | Human rhinovirus 3C protease (HRV3C Protease) is a cysteine protease that recognizes the cleavage site of Leu-Glu-Val-Leu-Phe-Gln*Gly-Pro. It is supplied as a 47 kDa protein with both GST and Histidine tags for easy removal by His-Select or Glutathione agarose along with the cleaved tag. HRV3C Protease is capable of cleaving small peptides with the sequence of polyprotein processing sites. It cleaves after the glutamine residue. HRV cleavage site generally contains Gln/Gly scissile bond. Hrv3c protease is a recombinant restriction-grade cysteine protease. it folds into two topologically alike six-stranded β barrels. however, β barrels are different in length and ... with both gst and histidine tags for easy removal by his-select or glutathione agarose along with the cleaved tag. hrv3c protease has a therapeutic implication because of its unique protein structure. it may be used for the biochemical and structural characterization conducted on hrv 3c protease along with the development of 3c protease inhibitors. Group: Enzymes. Synonyms: HRV3C Protease; HRV3C; Human rhinovirus 3C protease. HRV3C. Activity: > 1 units/μg. Storage: -20°C. Form: Supplied as a solution in 25 mM Tris-HCl, pH 8.0, 50 mM NaCl, 1 mM TCEP and 50% glycerol. Source: E. coli. Species: Human. HRV3C Protease; HRV3C; Human rhinovirus 3C protease. Cat No: NATE-0345. | |
| K-11777 | K-11777 is a potent, irreversible cysteine protease inhibitor. Besides, K11777 is not only a substrate but also a mechanism-based inhibitor of CYP3A4. Synonyms: 4-methyl-N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide; APC-3316; APC3316; APC 3316; K-11777; K 11777; K11777; K 777; K-777; K777; CRA-3316; CRA3316; CRA 3316. Grades: >98%. CAS No. 233277-99-1. Molecular formula: C32H38N4O4S. Mole weight: 574.74. | |
| K777 | K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC 50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi , and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC 50 values of 0.68 nM and 0.87 nM, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 233277-99-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119293. | |
| L-685,458 ((5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide) | Cell-permeable. A potent and selective γ-secretase inhibitor (IC50 = 17 nM). Displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of A β40 and A β42 peptides (IC50 values are 48 and 67nM respectively in human neuroblastoma cells). Group: Biochemicals. Alternative Names: (5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide. Grades: Highly Purified. CAS No. 292632-98-5. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Leupeptin hemisulfate | Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. Synonyms: Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfat. Grades: >98%. CAS No. 103476-89-7. Molecular formula: C20H38N6O4.1/2(H2SO4). Mole weight: 475.04. | |
| MDL-28170 | MDL-28170 (Calpain Inhibitor III) is a potent, selective and membrane-permeable cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration [1] [2]. MDL-28170 also block γ-secretase [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Calpain Inhibitor III. CAS No. 88191-84-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18236. | |
| MG-101 | MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with K i s of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Calpain inhibitor I; Ac-LLnL-CHO; ALLN. CAS No. 110044-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18964. | |
| Native Human Calpain 1 | Caplain 1 is a neutral calcium-dependent cysteine protease containing the EF-hand motif. The protease consists of two subunits; the larger subunit has four domains that are homologous with papain and calmodulin. The smaller subunit has one domain that shares homology with calmodulin. It is activated by micromolar levels of calcium and hence, it is also called as micro-calpain. Its activation leads to cellular protein degradation, neuronal cell degeneRation, and autoimmune demyelinating diseases such as multiple sclerosis. > 95% (sds-page). Applications: Human calpain 1 has been used in a study to assess how the crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. human calpain 1 has also been used in a study to investigate the synthesis, biological evaluation and molecular modelling of n-heterocyclic dipeptide aldehydes as selective calpain inhibitors. Group: Enzymes. Synonyms: calpain 1, μ-calpain; calcium-activated neutral protease I; EC 3.4.22.52. Enzyme Commission Number: EC 3.4.22.52. CAS No. 78990-62-2. Calpain 1. Storage: -70°C. Form: aqueous glycerol solution. Source: Human. calpain 1, μ-calpain; calcium-activated neutral protease I; EC 3.4.22.52. Cat No: NATE-0100. | |
| N-Ethylmaleimide | N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC 50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: NEM. CAS No. 128-53-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0843. | |
| N-Ethylmaleimide | N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides. Group: Monomers. Alternative Names: Ethylmaleimide; N-EthylMaleiMide; N-ethylmaleic imide; 1-ethylmaleimide; 1-Ethyl-1H-pyrrole-2,5-dione; ethvlmaleimide; n-ethyl-maleimid; N-Ethylmaleinimid; 1-ethyl-1H-pyrrole-2,5-dione; N-Ethylmaleimide; n-ethvlmaleimide; N-ethyl-maleimide. CAS No. 128-53-0. Product ID: 1-ethylpyrrole-2,5-dione. Molecular formula: 125.13. Mole weight: C6< / sub>H7< / sub>NO2< / sub>. CCN1C(=O)C=CC1=O. HDFGOPSGAURCEO-UHFFFAOYSA-N. 99%+. |  |
| N-Ethylmaleimide-d5 | N-Ethylmaleimide-d 5 is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: NEM-d5. CAS No. 360768-37-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D0843S. | |
| Odanacatib | Odanacatib, also known as MK-0822, is an inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption. Uses: For research used only. Synonyms: MK0822; MK-0822; MK 0822; Odanacatib. Grades: >98%. CAS No. 603139-19-1. Molecular formula: C25H27F4N3O3S. Mole weight: 525.56. | |
| Protease Inhibitor Cocktail Set III, EDTA-Free | Protease inhibitor cocktail III, EDTA-free for inhibiting aspartic, cysteine, and serine proteases as well as aminopeptidases in mammalian cells and tissues. Group: Fluorescence/luminescence spectroscopy. | |
| Protease Inhibitor Library | A unique collection of 344 protease and proteasome inhibitors for research in chemical genomics, and drug screening; - Targets include proteasome, DPP-4, Serine protease, cysteine protease, MMP, Aspartic proteinases, etc; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1100. Categories: Protease Inhibitor Libraries. |  |
| S130 | S130 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC 50 of 3.24 μM. S130 suppresses autophagy flux [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1160852-22-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112818. | |
| SNOG | SNOG is an amino acid nitric oxide donor that acts as a smooth muscle relaxant and platelet aggregation inhibitor. It also inhibits NF-κB activation, endothelial cell proliferation and cathepsin B (cysteine proteases). Uses: Bronchodilator agents. Synonyms: S-Nitroso-L-glutathione;S-Nitrosoglutathione; Nitrosoglutathione; Glutathione thionitrite; GNSO. Grades: ≥97%. CAS No. 57564-91-7. Molecular formula: C10H16N4O7S. Mole weight: 336.32. | |
| Tosyl phenylalanyl chloromethyl ketone | Tosyl phenylalanyl chloromethyl ketone (TPCK) is an irreversible inhibitor of chymotrypsin-like proteases. It also inhibits some cysteine proteases such as caspase, papain, bromelain or ficin. Uses: Alkylating agents. Synonyms: Nα-Tosyl-L-Phenylalanine Chloromethyl Ketone; TPCK; Tos-Phe-CH2Cl. Grades: ≥98%. CAS No. 402-71-1. Molecular formula: C17H18ClNO3S. Mole weight: 351.8. | |
| WRR483 | WRR483 is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model. It is an analogue of K-11777. It demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. It also eradicates parasite infection in a mouse model of acute Chagas' disease. It binds covalently to the active site cysteine of the protease. It has potential to be developed as a treatment for Chagas disease. Uses: Wrr483 has potential to be developed as a treatment for chagas disease. Synonyms: WRR-483; WRR 483; WRR483. N-((S)-5-guanidino-1-oxo-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)pentan-2-yl)-4-methylpiperazine-1-carboxamide. Grades: >98%. CAS No. 1076088-50-0. Molecular formula: C29H41N7O4S. Mole weight: 583.75. | |
| Z-FA-FMK | Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibitits papain and cruzain. Group: Biochemicals. Grades: Highly Purified. CAS No. 197855-65-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H23FN2O4, Molecular Weight: 386.42. US Biological Life Sciences. | Worldwide |
| Z-Leu-Leu-Tyr-α-keto aldehyde | Z-Leu-Leu-Tyr-α-keto aldehyde, an excellent inhibitor of serine and cysteine proteases, is an excellent inhibitor of chymotryptic-like activity of the proteasome with a Ki of about 3.0 nM. It may be valuable in identifying the role of the proteasome in the normal and abnormal pathways of protein catabolism in cells. Synonyms: L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-[(4-hydroxyphenyl)methyl]-2,3-dioxopropyl]-; Z-LLY-α-keto aldehyde; N-[(Benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-(4-hydroxyphenyl)-3,4-dioxo-2-butanyl]-L-leucinamide; benzyl ((S)-1-(((S)-1-(((S)-1-(4-hydroxyphenyl)-3,4-dioxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate; Cbz-Leu-Leu-Tyr-α-keto aldehyde. Grades: ≥95%. CAS No. 204649-66-1. Molecular formula: C30H39N3O7. Mole weight: 553.66. | |
| Z-Phe-DL-Ala-FMK | Z-FA-FMK is an irreversible cysteine protease inhibitor, and it also inhibits caspases-2, -3, -6, and -7. Z-FA-FMK suppresses the degradation of fibrillar collagen by fibroblasts and osteoclasts, and reduces LPS-induced cytokine production via inhibition of NF-kappaB-dependent gene expression in macrophages. Uses: Cysteine proteinase inhibitors. Synonyms: Z-Phe-DL-Ala-fluoromethylketone; Zfa-fmk; benzyloxycarbonyl-Phe-Ala-fluormethylketone; benzyloxycarbonylphenylalanyl-alanine fluoromethyl ketone; Carbamic acid, N-((1S)-2-((3-fluoro-1-methyl-2-oxopropyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-, phenylmethyl ester. Grades: ≥95%. CAS No. 197855-65-5. Molecular formula: C21H23FN2O4. Mole weight: 386.42. | |
| b-AP15 | b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.Not a general deubiquitinase inhibitor. Has minimal inhibition on recombinant and cytosolic nonproteasomal cysteine deubiquitinases. Synonyms: b-AP15; b-AP15; b-AP-15; USP14 Inhibitor III; UCHL5UCH37 Inhibitor II; NSC687852. Grades: >98%. CAS No. 1009817-63-3. Molecular formula: C22H17N3O6. Mole weight: 419.39. | |
| Calpain Inhibitor II | Calpain inhibitor II is a cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). It inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Calpain inhibitor II can block nitric oxide production by interfering with transcription of the inducible nitric oxide synthase gene, which is a weak inhibitor of proteasome. It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems. Uses: Cysteine proteinase inhibitors. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-; L-Leucinamide, N-acetyl-L-leucyl-N-[1-formyl-3-(methylthio)propyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide; ALLM; Calp II; CI 2; SUAM 312; N-acetylleucyl-leucyl-methioninal; Ac-Leu-Leu-Met-al; N-acetyl-L-leucyl-L-leucyl-L-methioninal. Grades: ≥98%. CAS No. 110115-07-6. Molecular formula: C19H35N3O4S. Mole weight: 401.57. | |
| Clasto-Lactacystin β-lactone | Clasto-Lactacystin β-lactone is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Clasto-lactacystin β-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive β-lactone. It is 20-fold more potent than Lactacystin. Synonyms: β-Clastolactacystin; Omuralide. Grades: ≥95%. CAS No. 154226-60-5. Molecular formula: C10H15NO4. Mole weight: 213.23. | |
| E-76 | E-76, a potent anticoagulant, is an inhibitor of coagulation factor VIIa. It acts by binding to an exosite on the VIIa protease domain and non-competitively inhibits the activation of factor X and amide hydrolytic activity. Synonyms: E-76; Acetyl-ALCDDPRVDRWYCQFVEG-amide; Ac-Ala-Leu-D-Cys-Asp-Asp-Pro-Arg-Val-Asp-Arg-Trp-Tyr-Cys-Gln-Phe-Val-Glu-Gly-NH2 (Disulfide bridge: Cys3-Cys13); N-acetyl-L-alanyl-L-leucyl-D-cysteinyl-L-alpha-aspartyl-L-alpha-aspartyl-L-prolyl-L-arginyl-L-valyl-L-alpha-aspartyl-L-arginyl-L-tryptophyl-L-tyrosyl-L-cysteinyl-L-glutaminyl-L-phenylalanyl-L-valyl-L-alpha-glutamyl-glycinamide (3->13)-disulfide. Grades: ≥95% by HPLC. CAS No. 1926163-13-4. Molecular formula: C97H139N27O29S2. Mole weight: 2211.47. | |
| Lactacystin | Lactacystin is a microbial metabolite isolated from streptomyces. It is a 20S proteasome inhibitor. Synonyms: (2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester. Grades: ≥95%. CAS No. 133343-34-7. Molecular formula: C15H24N2O7S. Mole weight: 376.42. | |
| Q-VD-OPH | QVD-OPH, also known as Quinoline-Val-Asp-Difluorophenoxymethylketone, is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 (IC50 = 25nm), caspase-1 (IC50 = 50nM), caspase-8 (IC50 = 100nM) and caspase-9 (IC50 = 430nM). It can be used in Alzheimer's studies relating to caspase-6, the cysteinyl protease involved in neurodegenerative conditions. As well it is an intermediate in the formation of Palinavir, a potent HIV protease inhibitor. Synonyms: Q-VD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone; quinoline-val-asp(OMe)-CH2-OPH. Grades: >98%. CAS No. 1135695-98-5. Molecular formula: C26H25F2N3O6. Mole weight: 513.8. | |
| WP1130 (Degrasyn) | A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Reported to cause accumulation of polyubiquitinated p53, JAK2 and Bcr-Abl, and reduce c-Myc and MCL-1 protein levels in several tumor cells and downregulate Stat3 and NF-kB activities (IC50 < 1uM in MCL cells) leading to tumor cell apoptosis (IC50 ~1.2uM in Z138 cells). Suggested to modify active site cysteine of DUB and inhibit USP5, UCH-L1, USP9x, USP14, and UCH37 activities (≥80% inhibition at 5uM) without affecting 20S proteasome. Reported to exert stronger antiproliferative and antitumor properties than STAT3 Inhibitor III, WP1066 in xenograft mouse models of CML and melanoma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Z-Ile-Glu(O-t-butyl)-Ala-Leucinal | PSI is a drug that blocks the action of proteasomes, protein complexes that degrade unneeded and damaged proteins. It causes dopaminergic cell death in vitro and prevents activation of NF-κB in response to TNF-α and okadaic acid by inhibiting IκB-α degradation. Uses: Cysteine proteinase inhibitors. Synonyms: Proteasome Inhibitor I; PSI peptide; L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-alpha-glutamyl-N-[(1S)-1-formyl-3-methylbutyl]-, 1,1-dimethylethyl ester. Grades: ≥ 90 % by HPLC. CAS No. 158442-41-2. Molecular formula: C32H50N4O8. Mole weight: 618.76. | |
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