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A proteinogenic amino acids involved in the biosynthesis of purines and pyrimidines. Inhibitor of serine palmitoyltransferase. A neuromodulator. Group: Biochemicals. Alternative Names: (R)-2-Amino-3-hydroxypropanoic Acid; (R)-2-Amino-3-hydroxypropanoic Acid; (R)-Serine; NSC 77689. Grades: Highly Purified. CAS No. 312-84-5. Pack Sizes: 5g. US Biological Life Sciences.
Worldwide
D-Serine
D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (R)-Serine. CAS No. 312-84-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-100808.
D-Serine 1,1-Dimethylethyl Ester
D-Serine 1,1-Dimethylethyl Ester. Group: Biochemicals. Alternative Names: D-Serine tert-Butyl Ester; tert-Butyl D-Serinate. Grades: Highly Purified. CAS No. 948296-15-9. Pack Sizes: 1g. Molecular Formula: C7H15NO3, Molecular Weight: 161.199999999999. US Biological Life Sciences.
Worldwide
D-Serine, 99+%
Loss on Drying: Group: Biochemicals. Alternative Names: ß-Hydroxyalanine. Grades: Highly Purified. CAS No. 312-84-5. Pack Sizes: 25g. US Biological Life Sciences.
Worldwide
D-serine ammonia-lyase
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-oxygen bond, releasing a water molecule (hence the enzyme's original classification as EC 4.2.1.14, D-serine dehydratase) and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Also acts, slowly, on D-threonine. Group: Enzymes. Synonyms: D-hydroxyaminoacid dehydratase; D-serine dehydrase; D-hydroxy amino acid dehydratase; D-serine hydrolase; D-serine dehydratase (deaminating); D-serine deaminase; D-serine hydro-lyase (deaminating). Enzyme Commission Number: EC 4.3.1.18. CAS No. 9015-88-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5278; D-serine ammonia-lyase; EC 4.3.1.18; 9015-88-7; D-hydroxyaminoacid dehydratase; D-serine dehydrase; D-hydroxy amino acid dehydratase; D-serine hydrolase; D-serine dehydratase (deaminating); D-serine deaminase; D-serine hydro-lyase (deaminating). Cat No: EXWM-5278.
D-Serine benzyl ester hydrochloride
D-Serine benzyl ester hydrochloride. Group: Biochemicals. Alternative Names: D-Ser-OBzl·HCl; D-b-Hydroxyalanine benzyl ester hydrochloride. Grades: Highly Purified. CAS No. 151651-44-4. Pack Sizes: 2g, 5g, 10g, 25g. US Biological Life Sciences.
N-Fmoc-D-serine is an N-Fmoc-protected form of D-Serine. D-Serine is a neurotransmitter that is concentrated in the mammalian brain, and is one of the very few amino acids that occur in the D- and L-configurations in significant amounts. D-Serine is a potent agonist of the N-methyl-D-aspartate (NMDA) receptor in the brain, which is associated with schizophrenia. Use of D-Serine has been considered as an additional therapy for refractory schizophrenic patients. Synonyms: Fmoc-D-Ser-OH; Fmoc-D-β-Hydroxyalanine; (R)-Fmoc-2-amino-3-hydroxypropionic acid. Grades: ≥ 98% (HPLC). CAS No. 116861-26-8. Molecular formula: C18H17NO5. Mole weight: 327.30.
N-α-Carbobenzoxy-N-α-methyl-O-(t-butyl)-D-serine dicyclohexylammonium salt
Synonyms: D-Serine, N-benzoyl-; Bz-D-Ser-OH; benzoyl-D-serine. Grades: >95% by HPLC. CAS No. 86808-09-5. Molecular formula: C10H11NO4. Mole weight: 209.20.
N-Fmoc-D-serine
N-Fmoc-D-serine is an N-Fmoc-protected form of D-Serine (S270975). D-Serine is a neurotransmitter that is concentrated in the mammalian brain, and is one of the very few amino acids that occur in the D- and L-configurations in significant amounts. D-Serine is an potent agonist of the N-methyl-D-aspartate (NMDA) receptor in the brain, which is associated with schizophrenia. Use of D-Serine has been considered as an additional therapy for refractory schizophrenic patients. Group: Biochemicals. Grades: Highly Purified. CAS No. 116861-26-8. Pack Sizes: 1g, 5g. Molecular Formula: C18H17NO5, Molecular Weight: 327.33. US Biological Life Sciences.
Worldwide
N-Methyl-D-serine
Synonyms: Me-D-Ser-OH; (R)-3-Hydroxy-2-(methylamino)propanoic acid; D-Serine, N-Methyl-; methyl-D-serine. Grades: >95% by HPLC. CAS No. 915405-01-5. Molecular formula: C4H9NO3. Mole weight: 119.12.
N,N,O-Tribenzyl-D-serine
Protected D-serine. Group: Biochemicals. Alternative Names: (R)-2-[Bis (phenylmethyl)amino]-3- (phenylmethoxy)-1-propanoic Acid Phenylmethyl Ester. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
(tert-Butoxycarbonyl)-D-serine is a serine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 6368-20-3. Pack Sizes: 100 g; 500 g. Product ID: HY-W002294.
2-Amino-1,3-propanediol-d4
Useful in stabilizing of perfume oils. Alkylamine that can be used to inactivate D-serine dehydratase via a transimination of enzyme-linked cofactor. Group: Biochemicals. Alternative Names: 1,3-Dihydroxy-2-propylamine-d4; 1, 3-Dihydroxyisopropyl amine-d4; 2-Amino-1,3-dihydroxypropane-d4; 2-Amino-1,3-propanediol-d4; 2-Aminoglycerol-d4; 2-Aminopropane-1,3-diol-d4; 2-Hydroxy-1- (hydroxymethyl) ethylamine-d4; NSC 93746-d4; Serinol-d4. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
3-hydroxy acid dehydrogenase
The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids. The highest activity is seen with L-allo-threonine and D-threonine. The enzyme from Escherichia coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2-methylpropanoate. The enzyme has no activity with NAD+ or L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase). Group: Enzymes. Synonyms: ydfG (gene name); YMR226c (gene name). Enzyme Commission Number: EC 1.1.1.381. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0300; 3-hydroxy acid dehydrogenase; EC 1.1.1.381; ydfG (gene name); YMR226c (gene name). Cat No: EXWM-0300.
Acein
Acein is a high-affinity angiotensin-converting enzyme (ACE) ligand with a Kd of 2.79 nM. It potentiates NMDA+ D-serine-induced dopamine release from the striatum in vivo and striatal slices in vitro. Synonyms: L-Alanine, L-prolyl-L-prolyl-L-threonyl-L-threonyl-L-threonyl-L-lysyl-L-phenylalanyl-L-alanyl-; L-Prolyl-L-prolyl-L-threonyl-L-threonyl-L-threonyl-L-lysyl-L-phenylalanyl-L-alanyl-L-alanine; H-Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala-OH. Grades: ≥95%. CAS No. 2022202-76-0. Molecular formula: C43H68N10O13. Mole weight: 933.06.
Acein acetate
Acein acetate is a high-affinity angiotensin-converting enzyme (ACE) ligand with a Kd of 2.79 nM. It potentiates NMDA+ D-serine-induced dopamine release from the striatum in vivo and striatal slices in vitro. Synonyms: H-Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala-OH.CH3CO2H; L-prolyl-L-prolyl-L-threonyl-L-threonyl-L-threonyl-L-lysyl-L-phenylalanyl-L-alanyl-L-alanine acetate. Grades: ≥95%. Molecular formula: C45H72N10O15. Mole weight: 993.11.
Albomycin δ1
It is produced by the strain of Streptomyces subtropicus. It has anti-gram-positive and negative bacterial activities. The iron was removed with hydroxyquinoline, and the antibacterial activity disappeared. The FeCl3 solution was added to restore the activity completely. Synonyms: albomycin delta(1); CHEBI:83206; [N(5)-acetyl-N(5)-(hydroxy-kappaO)-L-ornithyl-N(5)-acetyl-N(5)-(hydroxy-kappaO)-L-ornithyl-N(5)-acetyl-N(5)-(hydroxy-kappaO)-L-ornithyl-L-seryl-(3S)-3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrothiophen-2-yl]-D-serinato(3-)]iron; iron(3+) N(5)-acetyl-N(5)-oxido-L-ornithyl-N(5)-acetyl-N(5)-oxido-L-ornithyl-N(5)-acetyl-N(5)-oxido-L-ornithyl-L-seryl-(3S)-3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrothiophen-2-yl]-D-serine. CAS No. 1414-39-7. Molecular formula: C36H58FeN10O18S3+. Mole weight: 1006.81.
Albomycin δ2
It is produced by the strain of Streptomyces subtropicus. It has anti-gram-positive and negative bacterial activities. The iron was removed with hydroxyquinoline, and the antibacterial activity disappeared. The FeCl3 solution was added to restore the activity completely. Synonyms: albomycin delta(2); CHEBI:83215; [N(5)-acetyl-N(5)-(hydroxy-kappaO)-L-ornithyl-N(5)-acetyl-N(5)-(hydroxy-kappaO)-L-ornithyl-N(5)-acetyl-N(5)-(hydroxy-kappaO)-L-ornithyl-L-seryl-(3S)-3-{(2R,3R,4R,5R)-5-[4-(carbamoylimino)-3-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl]-3,4-dihydroxytetrahydrothiophen-2-yl}-D-serinato(3-)]iron; iron(3+) N(5)-acetyl-N(5)-oxido-L-ornithyl-N(5)-acetyl-N(5)-oxido-L-ornithyl-N(5)-acetyl-N(5)-oxido-L-ornithyl-L-seryl-(3S)-3-{(2R,3R,4R,5R)-5-[4-(carbamoylimino)-3-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl]-3,4-dihydroxytetrahydrothiophen-2-yl}-D-serine. Molecular formula: C37H60FeN12O18S3+. Mole weight: 1048.85.
BMS-181184
BMS-181184 is an antifungal antibiotic produced by Actinomadura sp. AB1236 in a medium containing D-serine or D-cycloserine. It has activity against pathogenic fungi such as yeast, Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus and Trichophyton. Synonyms: D-Serine, N-((5-((6-deoxy-3-O-beta-D-xylopyranosyl-beta-D-galactopyranosyl)oxy)-5,6,8,13-tetrahydro-1,6,9,14-tetrahydroxy-11-methoxy-3-methyl-8,13-dioxobenzo(a)naphthacen-2-yl)carbonyl)-, (5S-trans)-. CAS No. 139272-69-8. Molecular formula: C39H41NO20. Mole weight: 843.74.
BMS-181532
BMS-181532 is an antifungal antibiotic produced by Actinomadura sp. AB1236 in a medium containing D-serine or D-cycloserine. It has activity against pathogenic fungi such as yeast, Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus and Trichophyton. Synonyms: BMS 181532. CAS No. 146877-08-9. Molecular formula: C34H33NO16. Mole weight: 711.62.
Boc-D-Ser(Bzl)-OH
Standard building block for introduction of D-serine amino-acid residues by Boc SPPS. Uses: Peptide synthesis. Group: Amino acids. Alternative Names: Boc-D-Ser(Bzl)-OH, N-α-t.-Boc-O-benzyl-D-serine. CAS No. 47173-80-8. Mole weight: 295.33. Catalog: ACM47173808.
Boc-D-Ser-OH
Standard building block for introduction of D-serine amino-acid residues by Boc SPPS. Uses: Peptide synthesis. Group: Amino acids. Alternative Names: Boc-D-Ser-OH, N-α-t.-Boc-D-serine. CAS No. 6368-20-3. Mole weight: 205.21. Catalog: ACM6368203.
Buserelin Acetate
Buserelin acetate is an imputity of Buserelin, which is a synthetic analogue of gonadotropin-releasing hormone (GnRH). It functions via binding to GnRH receptors. Buserelin is primarily used for the treatment of prostate cancer and endometriosis. Uses: Fertility agents, female. Synonyms: H-Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt.CH3CO2H; L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-L-proline ethylamide acetic acid; 6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor Acetate; Estomal; Suprafact; Suprecur; Receptal; Supremon. Grades: ≥95%. CAS No. 68630-75-1. Molecular formula: C62H90N16O15. Mole weight: 1299.48.
Buserelin Acetate
Gondadotropin-releasing hormone agonist, used to treat hormone-responsive cancers such as prostate and breast cancer. Synthetic nonapeptide agonist analog of LH-RH. Antineolpastic (hormonal). Group: Biochemicals. Alternative Names: 6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor Monoacetate; Estomal; Suprafact; Suprecur; Supremon. Grades: Highly Purified. CAS No. 68630-75-1. Pack Sizes: 10mg. Molecular Formula: C??H??N??O??, Molecular Weight: 1299.48. US Biological Life Sciences.
Worldwide
Cycloserine Impurity 1
D-Serine is a proteinogenic amino acids involved in the biosynthesis of purines and pyrimidines. It is a inhibitor of serine palmitoyltransferase. It is also a neuromodulator. Synonyms: D-Serine; (R)-2-Amino-3-hydroxypropanoic Acid; (R)-2-Amino-3-hydroxypropanoic Acid; (R)-Serine; NSC 77689. Grades: ≥ 99% (Titration: anhydrous basis). CAS No. 312-84-5. Molecular formula: C3H7NO3. Mole weight: 105.09.
Cycloserine Impurity 2
Cycloserine Impurity 2 is a derivative of Cycloserine, renowned for its remarkable efficacy in treating tuberculosand sundry bacterial afflictions. Synonyms: D-Serine Methyl Ester Hydrochloride; (R)-2-Amino-3-hydroxypropionic Acid Methyl Ester Hydrochloride; (R)-Methyl 2-Amino-3-hydroxypropanoate Hydrochloride; Methyl D-Serinate Hydrochloride. Grades: ≥ 98% (HPLC). CAS No. 5874-57-7. Molecular formula: C4H10ClNO3. Mole weight: 155.58.
D-Amino acid oxidase (Immobilized)
D-Amino acid oxidase is an enzyme to metabolize exogenous D-amino acids in animals for detoxifying action. D-Amino acid oxidase also modulates the level of D-serine in brain [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9000-88-8. Pack Sizes: 25 U. Product ID: HY-P2986.
Daptomycin Impurity-3
Daptomycin Impurity-3 is an impurity of Daptomycin, which is a lipopeptide antibiotic used to treat systemic infections and life-threatening infections caused by gram-positive organisms. Synonyms: N-decanoyl-Trp-D-Asn-Asp-Thr-Gly-Orn-Asp-D-Ser-Asp-Gly-D-Ser-3Me-Glu-Kyn-OH (ε1-lactone); 8-D-Serinedaptomycin; Daptomycin, 8-D-serine-. CAS No. 921590-20-7. Molecular formula: C72H101N17O27. Mole weight: 1636.69.
(Des-Gly10,D-His2,D-Ser4,D-Leu6,Pro-NHEt9)-LHRH
(Des-Gly10,D-His2,D-Ser4,D-Leu6,Pro-NHEt9)-LHRH is the impurity F of the Leuprorelin. Synonyms: (D-His2,D-Ser4)-Leuprolide; Pyr-D-His-Trp-D-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt; Leuprolide Acetate EP Impurity F; Leuprorelin EP Impurity F; L-Prolinamide, 5-oxo-L-prolyl-D-histidyl-L-tryptophyl-D-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-; [2-D-Histidine,4-D-serine]leuprorelin; (S)-N-Ethyl-1-(((S)-5-oxopyrrolidine-2-carbonyl)-D-histidyl-L-tryptophyl-D-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl)pyrrolidine-2-carboxamide. Grades: ≥95%. CAS No. 1872435-00-1. Molecular formula: C59H84N16O12. Mole weight: 1209.42.
DL-Serine
DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV) [1]. Uses: Scientific research. Group: Natural products. CAS No. 302-84-1. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-Y0507.
(D-Ser1)-ACTH (1-24) (human, bovine, rat)
(D-Ser1)-ACTH (1-24) (human, bovine, rat) is a seminal peptide hormone within the scientific community, plays the role of an adrenocorticotropic hormone (ACTH) receptor agonist. Its diverse applications in both research and therapy encompass disorders characterized by adrenal insufficiency, the formidable Cushing's syndrome and an array of conditions impacting the adrenal cortex. Synonyms: (D-Ser1)-Tetracosactide; H-D-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH; α1-24-Corticotropin, 1-D-serine-; Proline, D-seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-; D-Ser1-Met4-tetracosapeptide; Ba 38522. Grades: ≥95%. CAS No. 18067-65-7. Molecular formula: C136H210N40O31S. Mole weight: 2933.44.
(D-Ser4)-Leuprolide Trifluoroacetic Acid Salt
(D-Ser4)-Leuprolide Trifluoroacetic Acid Salt. Group: Biochemicals. Alternative Names: 4-D-serine-6-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing hormone-releasing Factor (pig) 2,2,2-Trifluoroacetate. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C61H85F3N16O16, Molecular Weight: 1323.42. US Biological Life Sciences.
Standard building block of introduction of D-serine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Group: Amino acids. Alternative Names: Fmoc-D-Ser-OH, N-α-Fmoc-D-serine. CAS No. 116861-26-8. Mole weight: 327.33. Catalog: ACM116861268.
Fmoc-D-Ser(tBu)-OH
Standard building block of introduction of D-serine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Group: Amino acids. Alternative Names: Fmoc-D-Ser(tBu)-OH, N-α-Fmoc-O-t.-butyl-D-serine. CAS No. 128107-47-1. Molecular formula: C22H25NO5. Mole weight: 383.44. Catalog: ACM128107471.
Goserelin Acetate
Goserelin Acetate. Group: Biochemicals. Alternative Names: 6-[O-(1,1-Dimethylethyl)-D-serine]-1-9-luteinizing Hormone-releasing Factor (swine) 2- (Aminocarbonyl) hydrazide Acetate; Fertilan;D-Ser(But)6Azgly10-gonadorelin. Grades: Highly Purified. CAS No. 145781-92-6. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C??H??N??O??; x C?H?O?, Molecular Weight: 1269.41. US Biological Life Sciences.
Worldwide
Goserelin Acetate
Goserelin is a synthetic decapeptide analog of luteinizing hormone-releasing hormone (LHRH) with antineoplastic activity. Goserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Uses: Antineoplastic agents, hormonal. Synonyms: (D-Ser(tBu)6,Azagly10)-LHRH Acetate; Zoladex; 6-[O-(1,1-Dimethylethyl)-D-serine]-1-9-luteinizing Hormone-releasing Factor (swine) 2-(Aminocarbonyl)hydrazide Acetate; Fertilan; Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2.CH3CO2H; L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-N'-carbamoyl-L-prolinehydrazide acetic acid. Grades: 98%. CAS No. 145781-92-6. Molecular formula: C61H88N18O16. Mole weight: 1329.49.
Luvadaxistat
Luvadaxistat (TAK-831) is an orally active, highly selective, potent D-amino acid oxidase (DAAO) inhibitor. Luvadaxistat inhibits oxidative deamination of D-serine via the human recombinant DAAO enzyme with an IC 50 of 14 nM. Luvadaxistat significantly increases D-serine levels in the rodent brain, plasma, and cerebrospinal fluid. Luvadaxistat has the potential for schizophrenia research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-831. CAS No. 1425511-32-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109183.
Mutant Alanine Racemase Y354N from Geobacillus stearothermophilus, Recombinant
Mutant Alanine Racemase (Y354N) (mAR-Y354N), a pyridoxal 5-phosphate (PLP) dependent enzyme catalyzes the interconversion of the L-Serine to D-Serine. In WT Alanine Racemase Tyr354 plays a crucial role in defining the strict specificity of AR for alanine, in converting L-Alanine to D-Alanine, which is an important component of the peptidoglycan layer of bacterial cell wall. By mutating the active site Tyr 354 to Asn, the specificity of the enzyme changes and it becomes a racemase with dual specificity for L- Alanine and L-Serine. Applications: Mutant alanine racemase y354n can be used to convert l-serine to d-serine and l-alanine to d-alanine. Group: Enzymes. Synonyms: Alanine Racemase Y354N; alr; dal. Enzyme Commission Number: EC 5.1.1.1. Purity: > 99% by SDS-PAGE. Alanine Racemase. Mole weight: 43 kDa. Activity: > 50 mU/mg. Storage: Reconstituted enzyme can be stored in working aliquots at -20°C and use within 3 months. Avoid repeated freeze-thaw cycles. Form: Lyophilized. Source: E. coli and fused to His-tag at N-terminus. Species: Geobacillus stearothermophilus. Alanine Racemase Y354N; alr; dal; Alanine Racemase. Cat No: NATE-1639.
Pyridoxal 5'-phosphate
Pyridoxal 5'-phosphate is used as a cofactor for a wide range of enzymes including mitochondrial cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and d-serine dehydratase. Pyridoxal 5'-phosphate is used in the studies of PLP-dependent enzyme active sites. Applications: A normal coenzyme form of vitamin b6. Group: Coenzymes. Synonyms: 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde; Codecarboxylase; PLP; Pyridoxal 5-phosphate. CAS No. 853645-22-4. Purity: ≥98%. Mole weight: 247.14. Appearance: Crystalline powder. Form: Solid. 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde; Codecarboxylase; PLP; Pyridoxal 5-phosphate; Pyridoxal 5'-phosphate; 853645-22-4. Cat No: COEC-048.
serine racemase
A pyridoxal-phosphate protein that is highly selective for L-serine as substrate. D-Serine is found in type-II astrocytes in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D-aspartate (NMDA) receptors. The reaction can also occur in the reverse direction but does so more slowly at physiological serine concentrations. Group: Enzymes. Synonyms: SRR. Enzyme Commission Number: EC 5.1.1.18. CAS No. 77114-08-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5376; serine racemase; EC 5.1.1.18; 77114-08-0; SRR. Cat No: EXWM-5376.
A negative allosteric modulator selective for NR2A containingnMDA receptors (pIC50 = 6.8 and <4.3uM for NR2A and NR2B, respectively). No effect on NR2B-containingnMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containingnMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent. Group: Biochemicals. Grades: Highly Purified. CAS No. 852918-02-6. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
threo-3-hydroxy-D-aspartate ammonia-lyase
A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Delftia sp. HT23, also has activity against L-threo-3-hydroxyaspartate, L-erythro-3-hydroxyaspartate, and D-serine. Different from EC 4.3.1.20, erythro-3-hydroxy-L-aspartate ammonia-lyase and EC 4.3.1.16, threo-3-hydroxy-L-aspartate ammonia-lyase. Requires a divalent cation such as Mn2+, Co2+ or Ni2+. Group: Enzymes. Synonyms: D-threo-3-hydroxyaspartate dehydratase. Enzyme Commission Number: EC 4.3.1.27. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5286; threo-3-hydroxy-D-aspartate ammonia-lyase; EC 4.3.1.27; D-threo-3-hydroxyaspartate dehydratase. Cat No: EXWM-5286.
tyrosine phenol-lyase
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-carbon bond, releasing phenol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme also slowly catalyses similar reactions with D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine. Group: Enzymes. Synonyms: β-tyrosinase; L-tyrosine phenol-lyase (deaminating). Enzyme Commission Number: EC 4.1.99.2. CAS No. 9059-31-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4933; tyrosine phenol-lyase; EC 4.1.99.2; 9059-31-8; β-tyrosinase; L-tyrosine phenol-lyase (deaminating). Cat No: EXWM-4933.
D-Serinamide
Cas No. 104714-52-5. Molecular formula: C3H8N2O2. Mole weight: 104.1.
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