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12-Hydroxy-6-epi-albrassitriol is produced from cultures of Aspergillus sp. Synonyms: 6-epi-12-Hydroxyalbrassitriol; 1,2-Naphthalenedimethanol, 1,4,4a,5,6,7,8,8a-octahydro-1,4-dihydroxy-5,5,8a-trimethyl-, [1S-(1α, 4β, 4aα, 8aβ)]-; 1,2-Naphthalenedimethanol, 1,4,4a,5,6,7,8,8a-octahydro-1,4-dihydroxy-5,5,8a-trimethyl-, (1S,4R,4aS,8aS)-. Grades: 98.0%. CAS No. 178330-78-4. Molecular formula: C15H26O4. Mole weight: 270.36.
2-Hydroxy-1,4-naphthaquinone (Lawsone)
2-Hydroxy-1,4-naphthoquinone is the active ingredient of Lawsonia inermis (henna) leaves extract. It has potential antimicrobial activity and can be used for the detection of latent fingermarks on paper surfaces. Dyes and metabolites. Group: Biochemicals. Alternative Names: 2-Hydroxy-1,4-naphthalenedione; 1,4-Dihydro-1,4-dioxo-2-hydroxynaphthalene; 2-Hydroxy-1,4-naphthalenedione; 2-Hydroxy-1,4-naphthoquinone; 2-Hydroxynaphthoquinone; C.I. 75480; C.I. Natural Orange 6; Flower of Paradise; Henna; Henna (dye); Lawsone; Mehendi; Mendi; NSC 27285; NSC 52500; NSC 8625; Pakarli; Q 0; Quino Power LSN. Grades: Highly Purified. CAS No. 83-72-7. Pack Sizes: 50g, 100g, 250g, 500g. Molecular Formula: C??H?O?, Molecular Weight: 174.15. US Biological Life Sciences.
Worldwide
5-Hydroxy-1-tetralone
A metabolite of Levobunolol and d-Bunolol. Group: Biochemicals. Alternative Names: 1,2,3,4-Tetrahydro-1-oxo-5-hydroxynaphthalene; 5-Hydroxy-α-tetralone; 1,2,3,4-Tetrahydro-5-hydroxynaphthyl-1-one; 5-Hydroxy-3,4-dihydro-1(2H)-naphthalenone; 3,4-Dihydro-5-hydroxy-1(2H)-naphthalenone; 5-Hydroxy-1,2,3,4-tetrahydronaphthalen-1-one; 5-Hydroxy-3,4-dihydro-2H-naphthalen-1-one. Grades: Highly Purified. CAS No. 28315-93-7. Pack Sizes: 10g. US Biological Life Sciences.
Worldwide
7,8-Dihydro Naphthol
7,8-Dihydro-1-naphthalenol can be used as reagent/reactant in stereoselective preparation of indanes via chiral hypervalent iodine - mediated ring contraction of dihydronaphthalenes. Synonyms: 7,8-Dihydro-1-naphthol; 8-Hydroxy-1,2-dihydronaphthalene. Grades: > 95%. CAS No. 51927-48-1. Molecular formula: C10H10O. Mole weight: 146.19.
Acetylshikonin
Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity. Acetylshikonin is a non-selective cytochrome P450 inhibitor against all P450s (IC50 values range from 1.4-4.0 μM). Acetylshikonin is an AChE inhibitor and exhibits potent antiapoptosis activity. Group: Inhibitors. Alternative Names: (+)-5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone2-acet;4-naphthalenedione,2-(1-(acetyloxy)-4-methyl-3-pentenyl)-5,8-dihydroxy-(;4-naphthoquinone,5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-2-acetate;1,4-NAPHTHALENEDIONE,2-[1-(ACETYLOXY)-4-METHYL-3-PENTENYL]-5,8-DIHYDROXY-, (R)-;ACETYLSHIKONIN;ACETYLSHIKONIN: 1,4-NAPHTHALENEDIONE,2-[1-(ACETYLOXY)-4-METHYL-3-PENTENYL]-5,8-DIHYDROXY-, (R)-,;1,4-Naphthalenedione,2-[1-(acetyloxy)-4-methyl-;3-pentenyl]-5,8-dihydroxy-,(R)-. CAS No. 24502-78-1. Molecular formula: C18H18O6. Mole weight: 330.33. Purity: 0.98. Catalog: ACM24502781.
Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). It inhibits proliferation, migration and invasion of human Huh7 and Hep3B2.1-7 hepatocellular carcinoma cells via regulation of miR92a. Synonyms: 1,4-Naphthalenedione, 5,8-dihydroxy-6-[(1S)-1-hydroxy-4-methyl-3-penten-1-yl]-; 1,4-Naphthalenedione, 5,8-dihydroxy-6-(1-hydroxy-4-methyl-3-pentenyl)-, (S)-; 1,4-Naphthalenedione, 5,8-dihydroxy-6-[(1S)-1-hydroxy-4-methyl-3-pentenyl]-; 1,4-Naphthoquinone, 5,8-dihydroxy-6-(1-hydroxy-4-methyl-3-pentenyl)-, (-)-; 5,8-Dihydroxy-6-[(1S)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione; Alkanet extract; Alkanet extract, inspissated; Alkanna red; Anchusa acid; Anchusin; C.I. 75530; C.I. Natural Red 20. Grades: ≥95%. CAS No. 23444-65-7. Molecular formula: C16H16O5. Mole weight: 288.30.
AMI-1
AMI-1 is a cell-permeable inhibitor which inhibits protein arginine N-methyltransferase (PRMT) activity with IC50 of 8.81 μM for PRMT1 and IC50 of 3.04 μM for Hmt1p in vitro. MI-1 does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site and exhibits minimal effects on both SET (Sub39H1, Suv39H2, SET7) and non-SET (DOT1) lysine N-methyltransferases. Furthermore, AMI-1 prevents in vivo arginine methylation of cellular proteins and can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements, thus operating as a brake on certain hormone actions. Synonyms: 7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] disodium salt; 5,5'-Dihydroxy-2,2'-dinaphthylcarbamide-7,7'-disulfonic acid disodium salt; 6,6'-Ureylenebis(1-naphthol-3-sulfonic acid) disodium salt; 7,7'-Ureylenebis(4-hydroxy-2-naphthalenesulfonic acid) disodium salt; Carbonyl J disodium salt; I Acid Urea disodium salt; N,N'-Bis(5-hydroxy-7-sulfo-2-naphthyl)urea disodium salt; N,N'-Bis(7-sulfo-5-hydroxy-2-naphthyl)urea disodium salt; N,N'-Bis[1-hydroxy-3-sulfonaphthyl(6)]urea disodium salt; N,N'-Bis[1-oxy-3-sulfonaphthyl(6)]urea disodium salt; AMI-1 sodium salt; AMI 1; AMI1; J Acid Urea disodium salt. Grades: ≥98%. CAS No. 20324-87-2. Molecular formula: C21H14N2Na2O9S2. Mole weight: 548.45.
Des(2-methylbutyryl) lovastatin hydroxy acid sodium salt
Des(2-methylbutyryl) Lovastatin Hydroxy Acid Sodium Salt
An impurity of Lovastatin. Lovastatin is an HMG CoA reductase inhibitor used to treat high blood cholesterol. Synonyms: 3,5-Dihydroxy-7-(8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl)heptenoate Acid Sodium Salt; [1S-[1α(βS*, δS*), 2β, 6β, 8β, 8aα]]-1, 2, 6, 7, 8, 8a-hexahydro-β, δ, 8-trihydroxy-2, 6-dimethyl-1-naphthaleneheptanoic Acid Monosodium Salt. Grades: > 95%. CAS No. 132294-94-1. Molecular formula: C19H29O5Na. Mole weight: 360.42.
Dihydroxyaflavinine
Dihydroxyaflavinine is a metabolite of Aspergillus flavus and is a fungal toxin. It inhibits non-competitively GABAA receptor channel expressed in Xenopus oocytes. It displays oral toxicity to the corn earworm (Heliothis zea) and fall armyworm (Spodoptera frugiperda). Synonyms: 20,25-Dihydroxyaflavinine; 1H-Benzo[d]naphthalene-1,5-diol, 2,3,4,4a,5,6,7,7a,10,11-decahydro-9-[(1R)-2-hydroxy-1-methylethyl]-8-(1H-indol-3-yl)-4,4a,7-trimethyl-, (1R,4S,4aR,5S,7S,7aR,11aR)-rel-; 1H-Benzo(d)naphthalene-1,5-diol, 2,3,4,4a,5,6,7,7a,10,11-decahydro-9-(2-hydroxy-1-methylethyl)-8-(1H-indol-3-yl)-4,4a,7-trimethyl-, (1alpha, 4alpha, 4aalpha, 5beta, 7alpha, 7abeta, 9(R*), 11aR*)-. Grades: 98.0%. CAS No. 76410-56-5. Molecular formula: C28H39NO3. Mole weight: 437.61.
Direct Blue 218
Direct Blue 218 is an azo dye used in diagnostic imaging. Used in the prediction of rat carcinogenisis. Also used in textile dyes contributing to textile effluents and wastewaters. Environmental toxin on US EPA Toxic Release Inventory list (TRI) list. Group: Biochemicals. Alternative Names: [Tetrahydrogen -3, 3'- [ (3, 3'-dihydroxy-4, 4'-biphenylylene ) bis (azo) ] bis [5-amino-4-hydroxy-2, 7-naphthalene disulfonato] (4-) ] di-Copper Tetrasodium Salt; [ μ - [ [3, 3'- [ (3, 3'-Dihydroxy [1, 1'-biphenyl] -4, 4'-diyl) bis (azo) ] bis [5-amino-4-hydroxy-2, 7-naphthalene disulfonato] ] (8-) ] ] di-Cuprate (4-) Tetra sodium ; [ μ - [ [3, 3'- [ [3, 3'-Di (hydroxy- κ O) [1, 1'-biphenyl] -4, 4'-diyl] bis (azo- κ N1) ] bis [5-amino-4- (hydroxy- κ O) -2, 7-naphthalene disulfonato] ] (8-) ] ] di-Cuprate (4-) Tetrasodium;3,3'-[(3,3'-Dihydroxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydroxy-2,7-Naphthalenedisulfonic Acid Copper Complex; Amanil Supra Blue 9GL; C.I. 24401; Carta Blue VP; Direct Blue 218; Fastusol Blue 9GLP; Intralite Blue 8GLL; Pontamine Bond Blue B; Pontamine Fast Blue 7GLN. Grades: Purified. CAS No. 28407-37-6. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C??H??Cu?N?Na?O??S?, Molecular Weight: 1087.81. US Biological Life Sciences.
An inactive metabolite of Chlortetracycline (CTC). Group: Biochemicals. Alternative Names: (4S, 4aS, 6S, 8aS) -6- [ (1S) -7-Chloro-1, 3-dihydro-4-hydroxy-1- methyl -3-oxo-1-isobenzofuranyl] -4- (di methyl amino) -1, 4, 4a, 5, 6, 7, 8, 8a-octahydro-3, 8a-dihydroxy-1, 8-dioxo-2-naphthalene carboxamide; Isoaureomycin; 7-Chloroisotetracycline. Grades: Highly Purified. CAS No. 514-53-4. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Mevastatin Hydroxy Acid Sodium Salt
An active carboxylate of Mevastatin. It is a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase with hypocholesterolemic activity. It has been shown to be effective in reducing cholesterol synthesis in vivo, and thereby in lowering cholesterol levels in blood. Group: Biochemicals. Alternative Names: ( βR, δR, 1S, 2S, 8S, 8aR)-1, 2, 6, 7, 8, 8a-Hexahydro- β,δ-dihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic Acid Sodium Salt;[1S-[1α( βS*, δS*), 2α, 8 β(R*),8aα]]-1,2,6,7,8,8a-Hexahydro- β,δ-dihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid Monosodium Salt; ( βR, δR, 1S, 2S, 8S, 8aR)-1, 2, 6, 7, 8, 8a-Hexahydro- β,δ-dihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic Acid Monosodium Salt; ML 236B Sodium Salt. Grades: Highly Purified. CAS No. 99782-89-5. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Mevastatin Hydroxy Acid t-Butylamine Salt
A HMG-CoA reductase inhibitor. It has been shown to be effective in reducing cholesterol synthesis in vivo, and thereby in lowering cholesterol levels in blood. Group: Biochemicals. Alternative Names: ( βR, δR, 1S, 2S, 8S, 8aR)-1, 2, 6, 7, 8, 8a-Hexahydro- β,δ-dihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoate 2-Methyl-2-propanamine. Grades: Highly Purified. CAS No. 262285-80-3. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Orteronel
Orteronel. Group: Biochemicals. Alternative Names: TAK-700; 6- [ (7S) -6, 7-Dihydro-7-hydroxy-5H-pyrrolo [1, 2-c] imidazol-7-yl] -N- methyl -2-naphthalene carboxamide. Grades: Highly Purified. CAS No. 566939-85-3. Pack Sizes: 5mg. Molecular Formula: C18H17N3O2, Molecular Weight: 307.35. US Biological Life Sciences.
Worldwide
Pigment Red 176
Pigments. Alternative Names: C.I 12515;PIGMENT RED 176;n-(2,3-dihydro-2-oxo-1h-benzimidazol-5-yl)-3-hydroxy-4-[[2-methoxy-5-[(phenylamino)carbonyl]phenyl]azo]-2-naphthalenecarboxamide;3-HYDROXY-4-(2-METHOXY-4-PHENYLCARBAMOYL-PHENYLAZO)-NAPHTHALENE-2-CARBXYLIC ACID (2-OXO-2,3-DIHYDRO. CAS No. 12225-06-8. Molecular formula: C32H24N6O5. Mole weight: 572.58. Density: 1.43 g/cm³. Catalog: ACM12225068.
Pravastatin
Pravastatin is an antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase with IC50 of 5.6 μM. It is used in combination with diet, exercise, and weight loss for lowering cholesterol and preventing cardiovascular disease. It is a synthetic lipid-lowering agent. It lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing major histocompatibility complex II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. It is primarily used for the treatment of dyslipidemia and the prevention of cardiovascular disease. It is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. Uses: Pravastatin acts as a competitive inhibitor of hmg coa reductase. it is a synthetic lipid-lowering agent. it is primarily used for the treatment of dyslipidemia and the prevention of cardiovascular disease. it is used to reduce ldl cholesterol and triglyceride levels and increase hdl cholesterol in the prevention of cardiovascular disease. Synonyms: 1-Naphthaleneheptanoicacid, 1, 2, 6, 7, 8, 8a-hexahydro-b, d, 6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, [1S-[1a(bS*, dS*), 2a, 6a, 8b(R*), 8aa]]-; 3b-Hydroxycompactin; Eptastatin; Mevalothin; Pravastatin acid;Pravachol; Pravastatina; Pravastatine; Pravastatinum; (3R, 5R)-7-[(1S, 2S, 6S, 8S, 8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1, 2, 6, 7, 8, 8a-hexahydronaphthalen-1-yl]-3, 5-dihydroxyheptanoic acid. Grades: 98%. CAS No. 81093-37-0. Molecular formula: C23H36O7. Mole weight: 424.53.
Pravastatin Impurity E
An impurity of Pravastatin.Pravastatin is a member of the drug class of statins. It can be used for lowering cholesterol and preventing cardiovascular disease. Synonyms: (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-8-[(2S,3S)-3-hydroxy-2-methyl-1-oxobutoxy]-2-methyl-1-naphthaleneheptanoic Acid Sodium; (3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-8-[[(2S,3S)-3-hydroxy-2-methylbutanoyl]oxy]2-methyl1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic Acid Sodium; (S)-3''-Hydroxy Pravastatin Sodium Salt. Grades: > 95%. CAS No. 722504-45-2. Molecular formula: C23H35O8. Na. Mole weight: 462.52.
Pravastatin Impurity G
An impurity of Pravastatin.Pravastatin is a member of the drug class of statins. It can be used for lowering cholesterol and preventing cardiovascular disease. Synonyms: ETD6GNV9YV; Pravastatin Impurity G; 136590-28-8; 720666-74-0; UNII-ETD6GNV9YV; sodium; (3R,5R)-3,5-dihydroxy-7-[(1S,2S)-6-hydroxy-2-methyl-1,2-dihydronaphthalen-1-yl]heptanoate; (betaR,deltaR,1S,2S)-1,2-Dihydro-beta,delta,6-trihydroxy-2-methyl-1-naphthaleneheptanoic acid sodium; (betaR,deltaR,1S,2S)-1,2-Dihydro-beta,delta,6-trihydroxy-2-methyl-1-naphthaleneheptanoic Acid Sodium Salt(Pravasta; 1-Naphthaleneheptanoic acid, 1,2-dihydro-beta,delta,6-trihydroxy-2-methyl-, sodium salt (1:1), (betaR,deltaR,1S,2S)-. Grades: > 95%. CAS No. 136590-28-8. Molecular formula: C18H24O5. Mole weight: 320.39.
(R)-Shikonin
(R)-Shikonin is a naphthoquinone extracted from Lithospermum erythrorhizon and Alkanna sp. It is a natural cardioprotective, antioxidative and anti-inflammatory agent. Synonyms: Shikonin; Isoarnebin 4; Tokyo Violet; Shikonin S; (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthalenedione; R-5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-pentenyl]-1,4-naphthalenedione; (+)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone; (+)-Shikonin; (R)-(+)-Shikonin; NSC 252844; Shikonine; Tokyo Violet. Grades: ≥98%. CAS No. 517-89-5. Molecular formula: C16H16O5. Mole weight: 288.30.
Shikonin belongs naphthoquinone isolated from Arnebia sp. It is used as an anti-inflammatory treatment in traditional chinese medicine (TCM). It inhibits chemokine receptor function and suppresses HIV-1. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: (±)-Alkannin; (±)-Shikalkin; (±)-Shikonin; (±)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone; 1,4-Naphthalenedione, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-. Grades: >98%. CAS No. 54952-43-1. Molecular formula: C16H16O5. Mole weight: 288.29.
Simvastatin Hydroxy Acid Ethyl Ester
An impurity in Simvastatin. Group: Biochemicals. Alternative Names: ( βR, δR, 1S, 2S, 6R, 8S, 8aR)-8-(2, 2-Dimethyl-1-oxobutoxy)-1, 2, 6, 7, 8, 8a-hexahydro- β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 864357-87-9. Pack Sizes: 5mg. US Biological Life Sciences.
An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Synonyms: (βR,δR,1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro -β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic Acid Methyl Ester. Grades: > 95%. CAS No. 145576-26-7. Molecular formula: C26H42O6. Mole weight: 450.62.
An impurity in Simvastatin tablets. Group: Biochemicals. Alternative Names: ( βR, δR, 1S, 2S, 6R, 8S, 8aR)-8-(2, 2-Dimethyl-1-oxobutoxy)-1, 2, 6, 7, 8, 8a-hexahydro - β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic Acid Methyl Ester. Grades: Highly Purified. CAS No. 145576-26-7. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Simvastatin hydroxy acid sodium salt
A metabolite of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Synonyms: (βR,δR,1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic Acid Monosodium Salt; [1S-[1α(βS*, δS*), 2α, 6β, 8β, 8aα]]-8-(2, 2-Dimethyl-1-oxobutoxy)-1, 2, 6, 7, 8, 8a-hexahydro-β, δ-dihydroxy-2, 6-dimethyl-1-naphthaleneheptanoic Acid Monosodium Salt; Simvastatin Sodium; Simvastatin Sodium Salt. Grades: > 95%. CAS No. 101314-97-0. Molecular formula: C25H39O6. Na. Mole weight: 435.59 22.99.
Splitomicin
Splitomicin is a cell-permeable lactone derived from naphthol and known to be a potent selective inhibitor of Sir2 (silent information regulator 2) and HDAC. Splitomicin inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release. Synonyms: Splitomycin; 2-Hydroxy-1-Naphthalenepropionic Acid δ-Lactone; 2-Hydroxy-1-Naphthalenepropanoic Acid δ-Lactone; 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one; 1H-benzo[f]chromen-3(2H)-one; 1H,2H,3H-Naphtho[2,1-b]pyran-3-one; 1,2-Dihydro-3H-benzo[f]chromen-3-one. Grades: ≥98%. CAS No. 5690-3-9. Molecular formula: C13H10O2. Mole weight: 198.22.
A metabolite of Sertraline. Group: Biochemicals. Alternative Names: 4-(3,4-Dichlorophenyl)-3,4-dihydro-2-(R,S)-hydroxy-2H-naphthalen-1-one. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
(2S)-2-Methylbutanoic Acid (1S,3S,7S,8S,8aR)-8-[2-[(2R)-3,6-Dihydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydro-3-hydroxy-7-methyl-1-naphthalenyl Ester is an intermediate in the synthesis of Pravastatin (P702000) impurity. Group: Biochemicals. Grades: Highly Purified. CAS No. 1114834-63-7. Pack Sizes: 10mg, 25mg. Molecular Formula: C23H32O5. US Biological Life Sciences.
Worldwide
3,5-Dihydrodiol Simvastatin (Mixture of Diastereomers).
A metabolite of Simvastatin. Group: Biochemicals. Alternative Names: [1S-[1α,3α,4 β,6α,7 β,8 β(2S*,4S*),8a β]]-Butanoic Acid 2,2-Dimethyl-1,2,3,4,6,7,8,8a-octahydro-4,6-dihydroxy-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl Ester. Grades: Highly Purified. CAS No. 159143-77-8. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
(3S, 5S)-Dihydroxy Simvastatin
An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Synonyms: Butanoic acid, 2,?2-dimethyl-, 1,?2,?3,?4,?6,?7,?8,?8a-octahydro-4,?6-dihydroxy-3,?7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)?ethyl]?-1-naphthalenyl ester, [1S-[1α, ?3α, ?4β, ?6α, ?7β, ?8β(2S*, ?4S*)?, ?8aβ]?]?- (9CI). Grades: > 95%. CAS No. 159143-77-8. Molecular formula: C25H40O7. Mole weight: 452.58.
7-Hydroxy-3,4-dihydro-1H-naphthalen-2-one ≥95% (NMR). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences.
Worldwide
7-Hydroxy-3,4-Dihydro Cadalin
an impurity of cadalin. Synonyms: 2-Naphthalenol, 5,?6-dihydro-3,?8-dimethyl-5-(1-methylethyl)?-, (5S)?-. Grades: > 95%. CAS No. 72943-94-3. Molecular formula: C15H20O. Mole weight: 216.33.
Andrographolide
Andrographolide is a labdane diterpenoid. Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata. Andrographolide showed significant antihepatotoxic action in P. berghei K173- induced hepatic damage in M. natalensis. Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases. These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent. Group: Biochemicals. Alternative Names: (3E, 4S) -3- [2- [ (1R, 4aS, 5R, 6R, 8aS) -Decahydro-6-hydroxy-5- (hydroxymethyl) -5, 8a-dimethyl-2-methylene-1-naphthalenyl] ethylidene] dihydro-4-hydroxy-2 (3H) -furanone; [1R-[1α[E(S*)],4a β , 5α , 6α , 8aα ] ] -3- [2- [Decahydro-6-hydroxy-5- (hydroxymethyl) -5, 8a-dimethyl-2-methylene-1-naphthalenyl] ethylidene] dihydro-4-hydroxy-2 (3H) -furanone; 3α,14,15,18-Tetrahydroxy-5 β,9 βH,10α-labda-8(20),12-dien-16-oic Acid γ-Lactone; Andrographis; Andrographolid. Grades: Highly Purified. CAS No. 5508-58-7. Pack Sizes: 500mg. US Biological Life Sciences.
Worldwide
Arisantetralone A
Arisantetralone A is a lignan found in the fruits of Schisandra, which is a Chinese traditional medicine. Study shows that Arisantetralone A has the activity against leukemia P-388 in vitro. Synonyms: Wulignan A1; (2S,3S,4R)-7-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-6-methoxy-2,3-dimethyl-3,4-dihydro-2H-naphthalen-1-one. Grades: >98%. CAS No. 117047-76-4. Molecular formula: C20H22O5. Mole weight: 342.391.
ARV-471, an oral estrogen receptor PROTAC protein degrader for the treatment of breast cancer, is an heterobifunctional molecule that promotes the interaction between estrogen receptor alpha and intracellular E3 ligase complexes. It leads to ubiquitylation and subsequent degradation of estrogen receptors through the proteasome. In ER positive breast cancer cell lines, it has a strong ability to degrade ER with a half-maximal degradation concentration (DC50) of ~2 nM. Synonyms: ARV471; ARV 471; (S)-3-(5-(4-((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-, (3S)-; Vepdegestrant; (3S)-3-[1,3-Dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione. Grades: ≥95%. CAS No. 2229711-68-4. Molecular formula: C45H49N5O4. Mole weight: 723.90.
Betaenone B
Betaenone B is a phytotoxin produced by Phoma betae PS-14. Synonyms: 1(2H)-Naphthalenone, octahydro-2,7-dihydroxy-4-(3-hydroxy-1-oxopropyl)-2,4,5,7-tetramethyl-3-((1R)-1-methylpropyl)-, (2S,3R,4R,4aS,5R,7R,8aS)-. CAS No. 85269-23-4. Molecular formula: C21H36O5. Mole weight: 368.51.
Cambinol
Cambinol is a cell-permeable inhibitor of SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Synonyms: 2,3-dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-pyrimidinone; Cambinol; NSC 112546; SIRT1 Inhibitor II; SIRT2 Inhibitor VI; SIRT 1/2 inhibitor IV; NSC112546; NSC-112546; NSC 112546. CAS No. 14513-15-6. Molecular formula: C21H16N2O2S. Mole weight: 360.43.
Cambinol
Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). Group: Inhibitors. Alternative Names: cambinol, NSC112546, NSC-112546, SIRT1/2 Inhibitor IV, Cambinol, 14513-15-6, 5-(2-Hydroxy-naphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one, AC1MMYEF, NCIStruc1_001428, NCIStruc2_001159, SureCN3332758, CHEMBL491960, CTK8G3107, HMS3261K21, CCG-37240, DNC009417, NCGC00014121, NCI112546, AKOS002364304, AG-D-88787, CCG-221684. CAS No. 14513-15-6. Molecular formula: C21H16N2O2S. Mole weight: 360.43. Purity: 0.96. IUPACName: 5-[(2-hydroxynaphthalen-1-yl)methyl]-6-phenyl-2-sulfanylidene-1H-pyrimidin-4-one. Density: 1.41g/cm³. Catalog: ACM14513156.
Delaminomycin C is an extracellular Matrix receptor antagonist and immunomodulator produced by Streptomyces albulus MJ202-72F3. It inhibits cell adhesion ECM (Extracellular matrix), reduces immune response activity, and inhibits Gram-positive bacteria. Synonyms: (3Z)-3-[[2-[(3E,5E)-2,8-dihydroxy-7-methyldeca-3,5-dienyl]-1,6,8-trimethyl-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]-hydroxymethylidene]pyrrolidine-2,4-dione; 2H-Imidazol-2-one, 3-((2-(2,8-dihydroxy-7-methyl-3,5-decadienyl)-1,2,4a,5,6,7,8,8a-octahydro-1,6,8-trimethyl-1-naphthalenyl)carbonyl)-1,5-dihydro-4-hydroxy-. CAS No. 149779-40-8. Molecular formula: C29H43NO5. Mole weight: 485.65.
Dihydromevinolin is an impurity in Lovastatin bulk drug. It is produced by the strain of Aspergollus terreus. Synonyms: 4a,5-Dihydro Lovastatin; (2S)-2-Methylbutanoic Acid (1S,3S,4aR,7S,8S,8aS)-1,2,3,4,4a,7,8,8a-Octahydro- 3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester; (+)-Dihydromevinolin; Dihydrolovastatin; Dihydromevinol. Grades: > 95%. CAS No. 77517-29-4. Molecular formula: C24H38O5. Mole weight: 406.56.
Fibrostatin A is a proline hydroxylase inhibitor produced by Strptomyces catenulae. Synonyms: L-Cysteine, N-acetyl-S-((5,8-dihydro-1-hydroxy-3-methoxy-7-methyl-5,8-dioxo-2-naphthalenyl)methyl)-. CAS No. 91776-42-0. Molecular formula: C18H19NO7S. Mole weight: 393.41.
Fibrostatin B
Fibrostatin B is a proline hydroxylase inhibitor produced by Strptomyces catenulae. Synonyms: L-Cysteine, N-acetyl-S-((5,8-dihydro-1-hydroxy-3,6-dimethoxy-7-methyl-5,8-dioxo-2-naphthalenyl)methyl)-. CAS No. 91776-48-6. Molecular formula: C19H21NO8S. Mole weight: 423.44.
Fibrostatin C
Fibrostatin C is a proline hydroxylase inhibitor produced by Strptomyces catenulae. Synonyms: N-Acetyl-S-((5,8-dihydro-1-hydroxy-3,6-dimethoxy-5,8-dioxo-2-naphthalenyl)methyl)-L-cysteine. Grades: >98%. CAS No. 91776-47-5. Molecular formula: C18H19NO8S. Mole weight: 409.41.
Fibrostatin E
Fibrostatin E is a proline hydroxylase inhibitor produced by Strptomyces catenulae. Synonyms: L-Cysteine, N-acetyl-S-((5,8-dihydro-1-hydroxy-7-(hydroxymethyl)-3-methoxy-5,8-dioxo-2-naphthalenyl)methyl)-. CAS No. 91776-44-2. Molecular formula: C18H19NO8S. Mole weight: 409.41.
Fibrostatin F
Fibrostatin F is a proline hydroxylase inhibitor produced by Strptomyces catenulae. Synonyms: L-Cysteine, N-acetyl-S-((5,8-dihydro-3,6-dimethoxy-5,8-dioxo-1-hydroxy-7-(hydroxymethyl)-2-naphthalenyl)methyl)-. CAS No. 91776-45-3. Molecular formula: C19H21NO9S. Mole weight: 439.44.
(-)-Holostyligone
(-)-Holostyligone is a lignan isolated from the Holostylis reniformis. Synonyms: (2S,3S,4R)-4-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-2,3-dimethyl-3,4-dihydro-2H-naphthalen-1-one. Grades: >98%. CAS No. 887501-28-2. Molecular formula: C21H24O5. Mole weight: 356.418.
A non-selective ß-adrenoceptor antagonist. Group: Biochemicals. Alternative Names: (-)-5-[3,(t-Butylamino)-2-hydroxy-propoxy]-3,4-dihydro-1(2H)-naphthalenone, Hydrochloride. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences.
PIR 3.5 is a negative control of IPA 3, an allosteric inhibitor of group I PAK activation. Synonyms: 2-Naphthalenol, 6,6'-dithiobis-; 2-Naphthol, 6,6'-dithiodi-; 6,6'-Dithiobis[2-naphthalenol]; (6,6'-Dihydroxy-2,2'-dinaphthyl)disulfide; 2,2'-Dihydroxy-6,6'-dinaphthyl disulfide; 6,6'-Dithiodi(2-naphthol); Bis(6-hydroxy-2-naphthyl)disulfide; DDD (analytical); NSC 87629. Grades: ≥98% by HPLC. CAS No. 6088-51-3. Molecular formula: C20H14O2S2. Mole weight: 350.45.
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