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| Product | Description | |
|---|---|---|
| 2,4-Dichloro-7-nitroquinazoline | 2,4-Dichloro-7-nitroquinazoline is an intermediate used in the synthesis of 4-phenoxy-2- (1-piperazinyl) quinazolines as potent anticonvulsive and antihypoxic agents. It is also used to prepare quinazoline-based stem cell mobilizers targeting chemokine receptor CXCR4. Group: Biochemicals. Grades: Highly Purified. CAS No. 129112-65-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H3Cl2N3O2, Molecular Weight: 244.03. US Biological Life Sciences. |  Worldwide |
| 2-Amino-5,6-dichloro-3,4-dihydroquinazoline Hydrobromide | Anagrelide metabolite, the major metabolite in hematopoietic cell cultures. Group: Biochemicals. Alternative Names: 5,6-Dichloro-1,4-dihydro-2-quinazolinamine Hydrobromide; RL 603. Grades: Highly Purified. CAS No. 327602-34-6. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid (Anagrelide Impurity B) | Anagrelide impurity B. Quinazolines derivatives are attractive targets because they form an important component of pharmacologically active compounds and are associated with a wide spectrum of biological activities ranging from anticonvulsant and antibacterial to antidiabetic. Group: Biochemicals. Alternative Names: Anagrelide Impurity B. Grades: Highly Purified. CAS No. 1159977-03-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid Benzyl Ester Hydrobromide. | Anagrelide Impurity B derivative. Quinazolines derivative, attractive targets due to their many biological activities ranging from anticonvulsant and antibacterial to antidiabetic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid Ethyl Ester Hydrobromide | 2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid Ethyl Ester Hydrobromide. Group: Biochemicals. Alternative Names: Anagrelide Related Compound C. Grades: Highly Purified. CAS No. 70381-75-8. Pack Sizes: 10mg. Molecular Formula: C12H14BrCl2N3O2, Molecular Weight: 383.07. US Biological Life Sciences. | Worldwide |
| 2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid Hydrobromide (Anagrelide Impurity B) | Anagrelide impurity B. Quinazolines derivatives are attractive targets because they form an important component of pharmacologically active compounds and are associated with a wide spectrum of biological activities ranging from anticonvulsant and antibacterial to antidiabetic. Group: Biochemicals. Alternative Names: Anagrelide Impurity B. Grades: Highly Purified. CAS No. 1194434-39-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 2-Amino-5,6-dichloro-3(4H)-quinazolineacetic Acid Methyl Ester Monohydrobromide | 2-Amino-5,6-dichloro-3(4H)-quinazolineacetic Acid Methyl Ester is an impurity of Anagrelide (A637300, HCl salt) which is a phosphodiesterase inhibitor with antiplatelet activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 70380-52-8. Pack Sizes: 10mg, 100mg. Molecular Formula: C11H12BrCl2N3O2, Molecular Weight: 369.04. US Biological Life Sciences. | Worldwide |
| 4-Amino-2,5-dichloroquinazoline | Heterocyclic Organic Compound. Alternative Names: 4-Amino-2,5-dichloroquinazoline, 1107695-06-6, 2,5-dichloro-4-Quinazolinamine, 2,5-Dichloroquinazolin-4-amine, MolPort-020-394-697, ZINC26899462, AKOS015897252, TRA0030699, AJ-83283, AK-82828, SY016135, AB0057315, DB-023938, TC-307623, Z-4358, I08-0508. CAS No. 1107695-06-6. Molecular formula: C8H5Cl2N3. Mole weight: 214.051400 [g/mol]. Purity: 0.96. IUPACName: 2,5-dichloroquinazolin-4-amine. Canonical SMILES: C1=CC2=C(C(=C1)Cl)C(=NC(=N2)Cl)N. Catalog: ACM1107695066. |  |
| 2-(3',5'-Dichloro-2'-hydroxyphenyl)-4-quinazolinone | Heterocyclic Organic Compound. Alternative Names: 2-(3',5'-DICHLORO-2'-HYDROXYPHENYL)-4-QUINAZOLINE;2-(3'',5''-DICHLORO-2''-HYDROXYPHENYL)-4-QUINAZOLINONE;2-(3,5-Dichloro-2-hydroxyphenyl)-4(1H)-quinazolinone. CAS No. 1033-16-5. Molecular formula: C14H8Cl2N2O2. Mole weight: 307.13. Purity: 0.96. IUPACName: (2E)-2-(3,5-dichloro-6-oxocyclohexa-2,4-dien-1-ylidene)-1H-quinazolin-4-one. Canonical SMILES: C1=CC=C2C (=C1)C (=O)NC (=C3C=C (C=C (C3=O)Cl)Cl)N2. Density: 1.57g/cm³. ECNumber: 600-418-9. Catalog: ACM1033165. | |
| 2,5-Dichloro-N-methylaniline Hydrochloride | 2,5-Dichloro-N-methylaniline Hydrochloride acts as a reagent in the synthesis of N-alkylanilino methyl quinazolinediamines as antimalarial agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 1193389-58-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C7H7Cl2N; HCl, Molecular Weight: 176.043646. US Biological Life Sciences. | Worldwide |
| Anagrelide | Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity with IC50 value of 36 nM for inhibition of phosphodiesterase 3. It inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte hyperproliferation and differentiation. It is antithrombocythemic used for the treatment of overproduction of blood platelets. It is a synthetic quinazoline derivative and is used as is a platelet-reducing agent. It reduces platelet production through a decrease in megakaryocyte maturation. It inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. It is a drug used for the treatment of essential thrombocytosis or overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia. It was developed by Shire and has been listed. Uses: Anagrelide is used for the treatment of overproduction of blood platelets. it is a drug used for the treatment of essential thrombocytosis or overproduction of blood platelets. it also has been used in the treatment of chronic myeloid leukemia. Synonyms: 6,7-Dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one;6-Chloro-1,2,3,5-tetrahydro iMidazo [2, 1-b]quinazolin-2-one; Agrelin; Agrylin; Xagrid; Shire; Thromboreductin. Grades: 98%. CAS No. 68475-42-3. Molecular formula: C10H7Cl2N3O. Mole weight: 256.09. |  |
| AZ 10417808 | AZ 10417808 is a non-peptide and selective inhibitor of human caspase-3 with Ki value of 247 nM. It is selective over other caspases. It blocks cellular and biochemical features of apoptosis in cells. It also blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells. It is a bioactive chemical. Synonyms: AZ10417808; AZ-10417808; AZ 10417808; 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide; AQZ-1. Grades: ≥98% by HPLC. CAS No. 331645-84-2. Molecular formula: C18H13Cl2N5O4. Mole weight: 434.23. | |
| CI 1002 | CI 1002, an azepinoquinazoline derivative, has been found to be an acetylcholinesterase inhibitor that could probably be effective against cognitive dysfunction in Alzheimer's disease. It has already been discontinued by Pfizer. Synonyms: UNII-7U374ZW3YB; CI-1002; CI 1002; CI1002; 1,3-Dichloro-6,7,8,9,10,12-hexahydroazepino(2,1-b)quinazoline; 1,3-dichloro-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazoline; PD-142676; PD 142676; PD142676. Grades: 98%. CAS No. 149028-28-4. Molecular formula: C13H14Cl2N2. Mole weight: 269.17. | |
| CI-1002 hydrochloride | The hydrochloride salt form of CI 1002, an azepinoquinazoline derivative, has been found to be an acetylcholinesterase inhibitor that could probably be effective against cognitive dysfunction in Alzheimer's disease. Synonyms: CI-1002 hydrochloride; CI 1002 hydrochloride; CI1002 hydrochloride; UNII-I77CZ53Y9M; PharmaGSID_47259; 149062-75-9; 1,3-Dichloro-6,7,8,9,10,12-hexahydroazepino(2,1-b)quinazoline hydrochloride; CI-1002 hydrochloride; 1,3-dichloro-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazoline hydrochloride. Grades: 98%. CAS No. 149062-75-9. Molecular formula: C13H15Cl3N2. Mole weight: 305.63. | |
| Erlotinib impurity 3 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 2,4-dichloro-6,7-bis(2-methoxyethoxy)quinazoline. Grades: > 95%. Molecular formula: C14H16Cl2N2O4. Mole weight: 347.20. | |
| RG3039 | RG3039 is a potent DcpS inhibitor. It is used for the treatment for spinal muscular atrophy(SMA), which is caused by deletion or mutation of both copies of the SMN1 gene. It improves motor function in SMA mice. It also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models. It was developed by Repligen and now in Clinic Phase 1 with no progress. Uses: Rg3039 is used for the treatment for spinal muscular atrophy(sma). Synonyms: RG3039; RG 3039; RG-3039; PF06687859; PF 06687859; PF-06687859. 5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine;5-[[1-[(2,6-dichlorophenyl)methyl]piperidin-4-yl]methoxy]quinazoline-2,4-diamine. Grades: >98 %. CAS No. 1005504-62-0. Molecular formula: C21H23Cl2N5O. Mole weight: 432.35. | |
| 3-Hydroxy anagrelide | A major metabolite of Anagrelide. Synonyms: 6,7-Dichloro-1,5-dihydro-3-hydroxyimidazo[2,1-b]quinazolin-2(3H)-one. Grades: > 95%. CAS No. 733043-41-9. Molecular formula: C10H7Cl2N3O2. Mole weight: 272.09. | |
| 3-Hydroxy Anagrelide-13C3 | A major labeled metabolite of Anagrelide, an antithrombotic. Group: Biochemicals. Alternative Names: 6,7-Dichloro-1,5-dihydro-3-hydroxyimidazo[2,1-b]quinazolin-2(3H)-one. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| 5,6-Dichloro-1,4-dihydro-2-quinazolinamine | 5,6-Dichloro-1,4-dihydro-2-quinazolinamine. Group: Biochemicals. Alternative Names: Anagrelide impurity 5. Grades: Highly Purified. CAS No. 444904-63-6. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C8H7Cl2N3. US Biological Life Sciences. | Worldwide |
| 5-Acetoxy anagrelide | 5-Acetoxy anagrelide. Group: Biochemicals. Alternative Names: 6, 7-Dichloro-1, 2, 3, 5-tetrahydro-2-oxoimidazo[2, 1, b]quinazolin-5-yl acetate; 5-(Acetyloxy)-6,7-dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2(3H)-one. Grades: Highly Purified. CAS No. 1076198-71-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C12H9Cl2N3O3. US Biological Life Sciences. | Worldwide |
| 5-Acetoxy anagrelide | Heterocyclic Organic Compound. Alternative Names: 5-ACETOXY ANAGRELIDE;6,7-Dichloro-1,2,3,5-tetrahydro-2-oxoimidazo[2,1,b]quinazolin-5-yl Acetate. CAS No. 1076198-71-4. Molecular formula: C12H9Cl2N3O3. Mole weight: 314.12. Appearance: Light Yellow Oil. Purity: 0.96. IUPACName: (6,7-dichloro-2-oxo-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-5-yl) acetate. Canonical SMILES: CC (=O)OC1C2=C (C=CC (=C2Cl)Cl)NC3=NC (=O)CN13. Catalog: ACM1076198714. | |
| 5-Acetoxy Anagrelide (6, 7-Dichloro-1, 2, 3, 5-tetrahydro-2-oxoimidazo[2, 1, b]quinazolin-5-yl Acetate) | 5-Acetoxy Anagrelide (6, 7-Dichloro-1, 2, 3, 5-tetrahydro-2-oxoimidazo[2, 1, b]quinazolin-5-yl Acetate). Group: Biochemicals. Alternative Names: 6, 7-Dichloro-1, 2, 3, 5-tetrahydro-2-oxoimidazo[2, 1, b]quinazolin-5-yl Acetate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one monohydrochloride | 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one monohydrochloride. Group: Biochemicals. Alternative Names: Anagrelide hydrochloride. Grades: Highly Purified. CAS No. 58579-51-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C10H7Cl2N3O·HCl. US Biological Life Sciences. | Worldwide |
| Afatinib impurity E | Afatinib impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S,E)-N-(4-((3,4-dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. Molecular Formula: C24H25Cl2N5O3. Mole Weight: 502.39. Catalog: APB02319. |  |
| Afatinib Impurity SCl | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: (S,E)-N-(4-((3,4-Dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. Grades: ≥95%. CAS No. 2223677-63-0. Molecular formula: C24H25Cl2N5O3. Mole weight: 502.39. | |
| Anagrelide | Anagrelide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6,7-dichloro-3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one. CAS No. 68475-42-3. Molecular Formula: C10H7Cl2N3O. Mole Weight: 256.09. Catalog: APB68475423. | |
| Anagrelide Impurity 8 | Anagrelide Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-Hydroxy anagrelide; 6,7-dichloro-3-hydroxy-3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one. CAS No. 733043-41-9. Molecular Formula: C10H7Cl2N3O2. Mole Weight: 272.09. Catalog: APB733043419. | |
| BLU-554 | BLU-554 is a potent and selective inhibitor of fibroblast growth factor receptor 4 (FGFR4) (IC50 = 5 nM), which is promisingly to be used for the treatment of hepatocellular carcinoma and cholangiocarcinoma. Synonyms: BLU-554; BLU 554; BLU554, Fisogatinib; SCHEMBL16668287; EX-A841; MFCD30496704; N-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]oxan-4-yl]prop-2-enamide; BLU554. Grades: 99.08 %. CAS No. 1707289-21-1. Molecular formula: C24H24Cl2N4O4. Mole weight: 503.38. | |
| Ciliobrevin A | Ciliobrevin A is a Hedgehog pathway inhibitor; ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics. Ciliobrevin A inhibited proliferation of cerebellar granula neuron precursor cells, an important model of HH signaling. Group: Biochemicals. Alternative Names: 2,4-Dichloro-α-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)- β -oxo Benzene propanenitrile; HPI-4. Grades: Highly Purified. CAS No. 302803-72-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Methyl 2-(2-amino-5,6-dichloro-4h-quinazolin-3-yl)acetate | Synonyms: Anagrelide impurity 1. CAS No. 752151-24-9. Molecular formula: C11H11Cl2N3O2. Mole weight: 288.128. | |
| Rafigrelide | Rafigrelide is a platelet aggregation inhibitor, which plays a central role in atherothrombotic events. It could prolonge clot formation time and reduce clot strength. Uses: Rafigrelide plays a central role in atherothrombotic events. Synonyms: 6,7-Dichloro-3,3-dimethyl-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one;6,7-Dichloro-3,3-dimethyl-5,10-dihydroimidazo[2,1-b]quinazolin-2-one. Grades: >98 %. CAS No. 1029711-88-3. Molecular formula: C12H11Cl2N3O. Mole weight: 284.14. | |
| Z-3259 | XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including EGFR, HER2, ERBB2, VEGFR and EphB4. Synonyms: N-(3,4-Dichloro-5-fluorophenyl)-6-methoxy-7-[(1-methylazocan-5-yl)methoxy]quinazolin-4-amine; A11057. Grades: 98%. CAS No. 874286-84-7. Molecular formula: C24H27Cl2FN4O2. Mole weight: 493.40. | |
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