Dihydrofolate Reductase Suppliers USA
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Product | Description | |
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1-(3-Bromo-5-methoxyphenyl)ethanone Quick inquiry Where to buy Suppliers range | 1-(3-bromo-5-methoxyphenyl)ethanone is a reactant in designing a selective inhibitors of dihydrofolate reductase from Cryptosporidium. Group: Biochemicals. Grades: Highly Purified. CAS No. 1073642-71-3. Pack Sizes: 500mg, 1g. Molecular Formula: C9H9BrO2. US Biological Life Sciences. | Worldwide |
1-(Ethylthio)-2,5-dimethoxy-4-(2-nitroethenyl)benzene Quick inquiry Where to buy Suppliers range | A thiophenol derivative used in the preparation of dihydrofolate reductase inhibitors and potential antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 681160-70-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
2,4-Diamino-5-nitropyrimidine Quick inquiry Where to buy Suppliers range | Has a strong preferential binding to the enzyme dihydrofolate reductase in competition with the substrate, Dihydrofolic Acid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
2,5-Dimethoxythiophenol Quick inquiry Where to buy Suppliers range | 2,5-Dimethoxythiophenol is a thiophenol derivative used in the preparation of dihydrofolate reductase inhibitors and potential antitumor agents. Group: Biochemicals. Alternative Names: 2,5-Dimethoxybenzenethiol. Grades: Highly Purified. CAS No. 1483-27-8. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
2-Imino-4-thiobiuret Quick inquiry Where to buy Suppliers range | 2-Imino-4-thiobiuret is used in the design and synthesis of guanylthiourea derivatives which are potential inhibitors of plasmodium falciparum dihydrofolate reductase enzyme. 2-Imino-4-thiobiuret is also used as a reagent in recyclization reactions of N-arylmaleimides with polynucleophilic compounds. Group: Biochemicals. Grades: Highly Purified. CAS No. 2114-2-5. Pack Sizes: 5g, 10g. Molecular Formula: C2H6N4S, Molecular Weight: 118.16. US Biological Life Sciences. | Worldwide |
3-Bromo-5-methoxybenzaldehyde Quick inquiry Where to buy Suppliers range | 3-Bromo-5-methoxybenzaldehyde, can be used for the synthesis of novel scaffold, that led to the discovery of potent and selective Inhibitors of Dihydrofolate Reductase, used for the treatment of Cryptosporidiosis. It can also be used for the synthesis of Tetrahydrobenzoxepino [2, 3, 4-ij]isoquinolines derivatives, as Dopamine Receptor ligands. Group: Biochemicals. Grades: Highly Purified. CAS No. 262450-65-7. Pack Sizes: 1g, 10g. Molecular Formula: C8H7BrO2, Molecular Weight: 215.04. US Biological Life Sciences. | Worldwide |
4-Desmethoxy-4-bromo Trimethoprim Quick inquiry Where to buy Suppliers range | An impurity of Trimethoprim with inhibitory effects on the enzyme dihydrofolate reductase. Group: Biochemicals. Alternative Names: 5-[ (3-Bromo-4, 5-dimethoxyphenyl) methyl]-2, 4-diaminopyrimidine; 2, 4-Diamino-5- (5-bromoveratryl) pyrimidine; 2, 4-Diamino-5- (3, 4-dimethoxy-5-bromobenzyl) pyrimidine; 2, 4-Diamino-5- (3-bromo-4, 5-dimethoxybenzyl) pyrimidine; 5-(3'-Bromo-4',5'-dimethoxybenzyl)-2,4-diaminopyrimidine. Grades: Highly Purified. CAS No. 16285-82-8. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
ABTL-0812 Quick inquiry Where to buy Suppliers range | ABTL-0812 is an orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR), rictor-mTOR and dihydrofolate reductase with potential antineoplastic activity. It binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells upon oral administration. It was developed by Ability Pharmaceuticals and is in phase I/II clinical trials for the treatment of solid tumors. It received orphan drug designation in the E.U. and in the U.S. for the treatment of neuroblastoma in 2015. Uses: Abtl-0812 has potential antineoplastic activity. it is used for the treatment of solid tumors. Synonyms: ABTL0812; ABTL 0812; ABTL-0812; (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoate. Grades: 98%. CAS No. 57818-44-7. Molecular formula: C18H31O3. Mole weight: 294.93. | |
ACP-TMP Quick inquiry Where to buy Suppliers range | ACP-TMP is a derivative of Trimethoprim, which inhibits the enzyme dihydrofolate reductase. Synonyms: 3-Chloro-N- (17- (4- ( (2, 4-diaminopyrimidin-5-yl) methyl) -2, 6-dimethoxyphenoxy) -15-oxo-4, 7, 10-trioxa-14-azaheptadecyl) -4- ( (2- (2-methyl-2- ( (5- (trifluoromethyl) pyridin-2-yl) sulfonyl) propanamido) ethyl) thio) benzamide; Acp-tmp. Molecular formula: C45H58ClF3N8O11S2. Mole weight: 1043.57. | |
Brodimoprim Quick inquiry Where to buy Suppliers range | A structural derivative of Trimethoprim. A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent. Group: Biochemicals. Alternative Names: 5-[ (4-Bromo-3, 5-dimethoxyphenyl) methyl]-2, 4-pyrimidinediamine; 5-(4-Bromo-3, 5-dimethoxybenzyl)-2, 4-pyrimidinediamine; Hyprim; Ro 10-5970; Ro 105970; Unitrim. Grades: Highly Purified. CAS No. 56518-41-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Brodimoprim-d6 Quick inquiry Where to buy Suppliers range | A labeled structural derivative of Trimethoprim. A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent. Group: Biochemicals. Alternative Names: 5-[(4-Bromo-3,5-(dimethoxy-d6)phenyl)methyl]-2,4-pyrimidinediamine; 5-(4-Bromo-3,5-(dimethoxy-d6)benzyl)-2,4-pyrimidinediamine; Hyprim-d6; Ro 10-5970-d6; Ro 105970-d6; Unitrim-d6. Grades: Highly Purified. CAS No. 1346599-93-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
CI-898 hydrochloride Quick inquiry Where to buy Suppliers range | CI-898 is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). The presence of the cofactor NADPH enhances bind of CI-898 and DHFR. CI-898 inhibits growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also inhibits the growth of S. faecalis and S. aureus when used at concentrations less than 0.25 μg/ml. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine in mice with advanced stage P338 leukemia. Synonyms: Trimetrexate; CI 898 trihydrochloride; Trimetrexate trihydrochloride; TMTX. Grades: ≥98%. CAS No. 1658520-97-8. Molecular formula: C19H23N5O3·3HCl. Mole weight: 478.80. | |
Cycloguanil Quick inquiry Where to buy Suppliers range | Cycloguanil is a dihydrofolate reductase inhibitor. Synonyms: 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine. CAS No. 516-21-2. Molecular formula: C11H14ClN5. Mole weight: 251.718. | |
Cycloguanil hydrochloride Quick inquiry Where to buy Suppliers range | Cycloguanil is an active metabolite of proguanil, produced by the cytochrome P450 2C19 isoform. It is also an inhibitor of dihydrofolate reductase (DHFR) (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively). Uses: Antimalarials. Synonyms: Chloroguanide Triazine; NSC 3074; 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine monohydrochloride. Grades: ≥95%. CAS No. 152-53-4. Molecular formula: C11H14ClN5·HCl. Mole weight: 288.2. | |
Edatrexate Quick inquiry Where to buy Suppliers range | Edatrexate is a polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. Uses: Antineoplastic agents. Synonyms: 10-ethyl-deaza-aminopterin; 10-EDAM; 10 EDAM; 10EDAM; CGP-30694; CGP30694; CGP30694; D 03942; D-03942; D03942. CAS No. 80576-83-6. Molecular formula: C22H25N7O5. Mole weight: 467.49. | |
Folinic acid Quick inquiry Where to buy Suppliers range | Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate. It is a 5-formyl derivative of tetrahydrofolic acid and readily converted to other reduced folic acid derivatives, thus, has vitamin activity that is equivalent to that of folic acid. Since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate. Synonyms: leucovorin. Grades: >98%. CAS No. 58-05-9. Molecular formula: C20H23N7O7. Mole weight: 473.44. | |
Leucovorin Calcium Quick inquiry Where to buy Suppliers range | leucovorin calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Synonyms: IST5-002; IST5 002; IST5002; Benzyl-AMP; N6-Benzyladenosine-5'-phosphate; Folinic acid calcium salt; Calcium Folinate. Grades: >98%. CAS No. 1492-18-8. Molecular formula: C20H21N7O7.Ca. Mole weight: 513.52. | |
Methotrexate disodium Quick inquiry Where to buy Suppliers range | Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia). Synonyms: Amethopterin Sodium; Methotrexate Lederle; Metoart; Metotrexato Lederle; Sodium Methotrexate; N-[4-[[ (2, 4-Diamino-6-pteridinyl) methyl]methylamino]benzoyl]-L-glutamic Acid Disodium Salt; 4-amino-n(sup10)-methyl pteroyl glutamic acid disodium salt; amethopterin sodium. Grades: >98.0%. CAS No. 7413-34-5. Molecular formula: C20H20N8Na2O5. Mole weight: 498.40. | |
Ormetoprim Quick inquiry Where to buy Suppliers range | It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial. Group: Biochemicals. Alternative Names: 2, 4-Diamino-5- (6-methylveratryl) pyrimidine; 2, 4-Diamino-5-92-methyl-4, 5-dimethoxybenzyl) pyrimidine; Diamino-5- (6-methylveratryl) pyrimidine; NSC 95072; Ormethoprim; Ro 5-9754. Grades: Highly Purified. CAS No. 6981-18-6. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
PD 130883 Quick inquiry Where to buy Suppliers range | This active molecular is a potent lipophilic quinazoline antifolate and data show that marked PD130883 suppression of thymidylate synthase slows the rate but not the extent of tetrahydrofolate cofactor interconversion to dihydrofolate upon complete suppression of dihydrofolate reductase with trimetrexate. Synonyms: CHEMBL62769;123685-36-9;2-Amino-6-(((4-nitrophenyl)-2-propynylamino)methyl)-4(3H)quinazolinone;4(3H)-Quinazolinone,2-amino-6-[[(4-nitrophenyl)-2-propyn-1-ylamino]methyl]-;ACMC-20mqpf;PD-130883; PD130883; PD 130883. Grades: 95%. CAS No. 123685-36-9. Molecular formula: C18H15N5O3. Mole weight: 349.34. | |
Pemetrexed, Disodium Salt, Heptahydrate (N-[4-[(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium, LY-231514, Alimta) Quick inquiry Where to buy Suppliers range | Pemetrexed inhibits dihydrofolate reductase, thymidylate synthase and glycinamide ribonucleotide formyltransferase with Ki values of 7nM, 109nM and 9.3uM, respectively. Group: Biochemicals. Grades: Highly Purified. CAS No. 357166-29-1. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
Pyrimethamine Quick inquiry Where to buy Suppliers range | Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial. Group: Biochemicals. Alternative Names: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine; 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine; Chloridin; Chloridine; Daraprim; Khloridin; Malocide; Pirimecidan; Pirimetmin; NSC 3061; RP 4753. Grades: Highly Purified. CAS No. 58-14-0. Pack Sizes: 100mg, 500mg, 1g. Molecular Formula: C12H13ClN4. US Biological Life Sciences. | Worldwide |
Pyrimethamine-d3 Quick inquiry Where to buy Suppliers range | Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial. Group: Biochemicals. Alternative Names: 5-(4-Chlorophenyl)-6-ethyl-d3-2,4-pyrimidinediamine; 2,4-Diamino-5-(4-chlorophenyl)-6-ethyl-d3-pyrimidine; Chloridin-d3; Chloridine-d3; Malocide-d3; Pirimecidan-d3; Pirimetamin-d3; NSC 3061-d3; RP 4753-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
SDDC-0001190 Quick inquiry Where to buy Suppliers range | SDDC-0001190 is an inhibitor of dihydrofolate reductase (DHFR) uesd for the treatment of Mycobacterium tuberculosis (MTB). In a previous study, SDDC-0001190 showed high selectivity, low toxicity as well as decent pharmacokinetics with half-life 3.1 h and bioavailability 26%. Uses: The treatment of mycobacterium tuberculosis (mtb). Synonyms: SDDC 0001190; SDDC0001190. | |
Talotrexin ammonium Quick inquiry Where to buy Suppliers range | Talotrexin ammonium is the ammonium salt of an antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis, and cell division. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance. Synonyms: PT-523; PT 523; PT523; NSC 712783; NSC712783; NSC-712783; N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine. CAS No. 648420-92-2. Molecular formula: C28H34N10O6. Mole weight: 590.60. | |
Trimethoprim Quick inquiry Where to buy Suppliers range | Trimethoprim is a bacteriostatic antibiotic used mainly in the prophylaxis and treatment of urinary tract infections. It caused induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. It binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). Uses: Anti-infective agents, urinary; antimalarials; antimetabolites; folic acid antagonists. Synonyms: Trimpex; Proloprim. Grades: >98%. CAS No. 738-70-5. Molecular formula: C14H18N4O3. Mole weight: 290.32. | |
Trimethoprim Impurity B Quick inquiry Where to buy Suppliers range | 5-(3,4,5-Trimethoxybenzoyl)-2,4-pyrimidinediamine, a derivative of Trimethoprim, has potential for use in treating Cryptosporidiosis as an inhibitor of dihydrofolate reductase. Synonyms: 5-(3,4,5-Trimethoxybenzoyl)-2,4-pyrimidinediamine; (2,4-Diamino-5-pyrimidinyl)(3,4,5-trimethoxyphenyl)methanone; 2,4-Diamino-5-pyrimidinyl 3,4,5-trimethoxyphenylketone; Trimethoprim Related Compound B. CAS No. 30806-86-1. Molecular formula: C14H16N4O4. Mole weight: 304.31. | |
Trimethoprim Impurity F Quick inquiry Where to buy Suppliers range | 3-Desmethoxy-3-bromo Trimethoprim is an impurity of Trimethoprim that inhibits the enzyme dihydrofolate reductase. Synonyms: 3-Desmethoxy-3-bromo Trimethoprim; 5-[(3-Bromo-4,5-dimethoxyphenyl)methyl]-2,4-diaminopyrimidine; 2,4-Diamino-5-(5-bromoveratryl)pyrimidine; 2,4-Diamino-5-(3,4-dimethoxy-5-bromobenzyl)pyrimidine; 2,4-Diamino-5-(3-bromo-4,5-dimethoxybenzyl)pyrimidine; 5-(3'-Bromo-4',5'-dimethoxybenzyl)-2,4-diaminopyrimidine. CAS No. 16285-82-8. Molecular formula: C13H15BrN4O2. Mole weight: 339.19. | |
Trimethoprim lactate Quick inquiry Where to buy Suppliers range | Trimethoprim lactate salt is used as an antibacterial agent, primarily active against most gram-negative and gram-positive aerobic bacteria. It inhibits dihydrofolate reductase. Synonyms: Trimethoprim lactic Acid. Grades: ≥98%. CAS No. 23256-42-0. Molecular formula: C17H24N4O6. Mole weight: 380.39. | |
Trimetrexate Quick inquiry Where to buy Suppliers range | Trimetrexate is a potent competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase. Synonyms: CI-898; CI 898; CI898. Grades: >98%. CAS No. 52128-35-5. Molecular formula: C19H23N5O3. Mole weight: 369.42. |