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| Product | Description | |
|---|---|---|
| dihydrofolate reductase | The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. Group: Enzymes. Synonyms: tetrahydrofolate dehydrogenase; DHFR; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; folic acid reductase; folic reductase; dihydrofolic acid reductase; dihydrofolic reductase; 7,8-dihydrofolate reductase; NADPH-dihydrofolate reductase. Enzyme Commission Number: EC 1.5.1.3. CAS No. 9002-3-3. Dihydrofolate Reductase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1511; dihydrofolate reductase; EC 1.5.1.3; 9002-03-3; tetrahydrofolate dehydrogenase; DHFR; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; folic acid reductase; folic reductase; dihydrofolic acid reductase; dihydrofolic reductase; 7,8-dihydrofolate reductase; NADPH-dihydrofolate reductase. Cat No: EXWM-1511. |  |
| Dihydrofolate Reductase from human, Recombinant | Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q11?q22 region of chromosome 5. Bacterial species possesses distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar. Human dhfr is an 186 amino acid protein with an apparent molecular weight of 25 kda. it is 30% homologous to the e. coli protein and up to 70% homologous to vertebrate protein... from mycobacterium smegmatis. human dihydrofolate reductase has been used in a study to investigate the stable expression of green fluorescent protein and the targeted disruption of thioredoxin peroxidase-1 gene in babesia bovis. human dihydrofolate reductase has also been used in a study to investigate the structural analysis of human dihydrofolate reductase as a binary complex. Group: Enzymes. Synonyms: DHFR; dihydrofolate reductase; DYR; DHFRP1; Tetrahydrofolate NADP+ oxidoreductase; EC 1.5.1.3; tetrahydrofolate dehydrogenase; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; f | |
| 1-(3-Bromo-5-methoxyphenyl)ethanone | 1-(3-bromo-5-methoxyphenyl)ethanone is a reactant in designing a selective inhibitors of dihydrofolate reductase from Cryptosporidium. Group: Biochemicals. Grades: Highly Purified. CAS No. 1073642-71-3. Pack Sizes: 500mg, 1g. Molecular Formula: C9H9BrO2. US Biological Life Sciences. |  Worldwide |
| 1-(Ethylthio)-2,5-dimethoxy-4-(2-nitroethenyl)benzene | A thiophenol derivative used in the preparation of dihydrofolate reductase inhibitors and potential antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 681160-70-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2,4-Diamino-5-nitropyrimidine | Has a strong preferential binding to the enzyme dihydrofolate reductase in competition with the substrate, Dihydrofolic Acid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 2,5-Dimethoxythiophenol | 2,5-Dimethoxythiophenol is a thiophenol derivative used in the preparation of dihydrofolate reductase inhibitors and potential antitumor agents. Group: Biochemicals. Alternative Names: 2,5-Dimethoxybenzenethiol. Grades: Highly Purified. CAS No. 1483-27-8. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 2-Imino-4-thiobiuret | 2-Imino-4-thiobiuret is used in the design and synthesis of guanylthiourea derivatives which are potential inhibitors of plasmodium falciparum dihydrofolate reductase enzyme. 2-Imino-4-thiobiuret is also used as a reagent in recyclization reactions of N-arylmaleimides with polynucleophilic compounds. Group: Biochemicals. Grades: Highly Purified. CAS No. 2114-2-5. Pack Sizes: 5g, 10g. Molecular Formula: C2H6N4S, Molecular Weight: 118.16. US Biological Life Sciences. | Worldwide |
| 3-Bromo-5-methoxybenzaldehyde | 3-Bromo-5-methoxybenzaldehyde, can be used for the synthesis of novel scaffold, that led to the discovery of potent and selective Inhibitors of Dihydrofolate Reductase, used for the treatment of Cryptosporidiosis. It can also be used for the synthesis of Tetrahydrobenzoxepino [2, 3, 4-ij]isoquinolines derivatives, as Dopamine Receptor ligands. Group: Biochemicals. Grades: Highly Purified. CAS No. 262450-65-7. Pack Sizes: 1g, 10g. Molecular Formula: C8H7BrO2, Molecular Weight: 215.04. US Biological Life Sciences. | Worldwide |
| 4-Desmethoxy-4-bromo Trimethoprim | An impurity of Trimethoprim with inhibitory effects on the enzyme dihydrofolate reductase. Group: Biochemicals. Alternative Names: 5-[ (3-Bromo-4, 5-dimethoxyphenyl) methyl]-2, 4-diaminopyrimidine; 2, 4-Diamino-5- (5-bromoveratryl) pyrimidine; 2, 4-Diamino-5- (3, 4-dimethoxy-5-bromobenzyl) pyrimidine; 2, 4-Diamino-5- (3-bromo-4, 5-dimethoxybenzyl) pyrimidine; 5-(3'-Bromo-4',5'-dimethoxybenzyl)-2,4-diaminopyrimidine. Grades: Highly Purified. CAS No. 16285-82-8. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 6,7-dihydropteridine reductase | The substrate is the quinonoid form of dihydropteridine. Not identical with EC 1.5.1.3 dihydrofolate reductase. Group: Enzymes. Synonyms: 6,7-dihydropteridine:NAD(P)H oxidoreductase; DHPR; NAD(P)H:6,7-dihydropteridine oxidoreductase; NADH-dihydropteridine reductase; NADPH-dihydropteridine reductase; NADPH-specific dihydropteridine reductase; dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase; dihydropteridine reductase; dihydropteridine reductase (NADH); 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase. Enzyme Commission Number: EC 1.5.1.34. CAS No. 9074-11-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1516; 6,7-dihydropteridine reductase; EC 1.5.1.34; 9074-11-7; 6,7-dihydropteridine:NAD(P)H oxidoreductase; DHPR; NAD(P)H:6,7-dihydropteridine oxidoreductase; NADH-dihydropteridine reductase; NADPH-dihydropteridine reductase; NADPH-specific dihydropteridine reductase; dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase; dihydropteridine reductase; dihydropteridine reductase (NADH); 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase. Cat No: EXWM-1516. | |
| 7-Hydroxymethotrexate | 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5939-37-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-130569. |  |
| ABTL-0812 | ABTL-0812 is an orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR), rictor-mTOR and dihydrofolate reductase with potential antineoplastic activity. It binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells upon oral administration. It was developed by Ability Pharmaceuticals and is in phase I/II clinical trials for the treatment of solid tumors. It received orphan drug designation in the E.U. and in the U.S. for the treatment of neuroblastoma in 2015. Uses: Abtl-0812 has potential antineoplastic activity. it is used for the treatment of solid tumors. Synonyms: ABTL0812; ABTL 0812; ABTL-0812; (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoate. Grades: 98%. CAS No. 57818-44-7. Molecular formula: C18H31O3. Mole weight: 294.93. |  |
| ACP-TMP | ACP-TMP is a derivative of Trimethoprim, which inhibits the enzyme dihydrofolate reductase. Synonyms: 3-Chloro-N- (17- (4- ( (2, 4-diaminopyrimidin-5-yl) methyl) -2, 6-dimethoxyphenoxy) -15-oxo-4, 7, 10-trioxa-14-azaheptadecyl) -4- ( (2- (2-methyl-2- ( (5- (trifluoromethyl) pyridin-2-yl) sulfonyl) propanamido) ethyl) thio) benzamide; Acp-tmp. Molecular formula: C45H58ClF3N8O11S2. Mole weight: 1043.57. | |
| Aminopterin | Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a K i of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Aminofolic acid; APGA. CAS No. 54-62-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14518. | |
| Brodimoprim | A structural derivative of Trimethoprim. A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent. Group: Biochemicals. Alternative Names: 5-[ (4-Bromo-3, 5-dimethoxyphenyl) methyl]-2, 4-pyrimidinediamine; 5-(4-Bromo-3, 5-dimethoxybenzyl)-2, 4-pyrimidinediamine; Hyprim; Ro 10-5970; Ro 105970; Unitrim. Grades: Highly Purified. CAS No. 56518-41-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Brodimoprim | Brodimoprim (Ro 10-5970), a trimethoprim analogue, is an orally active dihydrofolate reductase inhibitor. Brodimoprim is highly active against a broad spectrum of gram-negative and gram-positive bacteria [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 10-5970. CAS No. 56518-41-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121341. | |
| Brodimoprim-d6 | A labeled structural derivative of Trimethoprim. A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent. Group: Biochemicals. Alternative Names: 5-[(4-Bromo-3,5-(dimethoxy-d6)phenyl)methyl]-2,4-pyrimidinediamine; 5-(4-Bromo-3,5-(dimethoxy-d6)benzyl)-2,4-pyrimidinediamine; Hyprim-d6; Ro 10-5970-d6; Ro 105970-d6; Unitrim-d6. Grades: Highly Purified. CAS No. 1346599-93-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| CI-898 hydrochloride | CI-898 is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). The presence of the cofactor NADPH enhances bind of CI-898 and DHFR. CI-898 inhibits growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also inhibits the growth of S. faecalis and S. aureus when used at concentrations less than 0.25 μg/ml. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine in mice with advanced stage P338 leukemia. Synonyms: Trimetrexate; CI 898 trihydrochloride; Trimetrexate trihydrochloride; TMTX. Grades: ≥98%. CAS No. 1658520-97-8. Molecular formula: C19H23N5O3·3HCl. Mole weight: 478.80. | |
| Cycloguanil | Cycloguanil is a dihydrofolate reductase inhibitor. Synonyms: 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine. CAS No. 516-21-2. Molecular formula: C11H14ClN5. Mole weight: 251.718. | |
| Cycloguanil hydrochloride | Cycloguanil is an active metabolite of proguanil, produced by the cytochrome P450 2C19 isoform. It is also an inhibitor of dihydrofolate reductase (DHFR) (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively). Uses: Antimalarials. Synonyms: Chloroguanide Triazine; NSC 3074; 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine monohydrochloride. Grades: ≥95%. CAS No. 152-53-4. Molecular formula: C11H14ClN5·HCl. Mole weight: 288.2. | |
| Diaveridine | Diaveridine (EGIS-5645) is a dihydrofolate reductase ( DHFR ) inhibitor with a K i of 11.5 nM for the wild type DHFR and also an antibacterial agent. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EGIS-5645. CAS No. 5355-16-8. Pack Sizes: 10 mM * 1 mL; 250 mg. Product ID: HY-B1902. | |
| dihydromethanopterin reductase [NAD(P)+] | The enzyme, characterized from the bacterium Methylobacterium extorquens, is involved in biosynthesis of dephospho-tetrahydromethanopterin. The specific activity with NADH is 15% of that with NADPH at the same concentration. It does not reduce 7,8-dihydrofolate (cf. EC 1.5.1.3, dihydrofolate reductase). Group: Enzymes. Synonyms: DmrA; H2MPT reductase; 5,6,7,8-tetrahydromethanopterin 5,6-oxidoreductase; dihydromethanopterin reductase. Enzyme Commission Number: EC 1.5.1.47. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1528; dihydromethanopterin reductase [NAD(P)+]; EC 1.5.1.47; DmrA; H2MPT reductase; 5,6,7,8-tetrahydromethanopterin 5,6-oxidoreductase; dihydromethanopterin reductase. Cat No: EXWM-1528. | |
| dihydromonapterin reductase | The enzyme, found in many Gram negative bacteria, also slowly reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate (cf. EC 1.5.1.3, dihydrofolate reductase). The enzyme has no activity with NADH. Group: Enzymes. Synonyms: FolM; H2-MPt reductase. Enzyme Commission Number: EC 1.5.1.50. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1532; dihydromonapterin reductase; EC 1.5.1.50; FolM; H2-MPt reductase. Cat No: EXWM-1532. | |
| Edatrexate | Edatrexate is a polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. Uses: Antineoplastic agents. Synonyms: 10-ethyl-deaza-aminopterin; 10-EDAM; 10 EDAM; 10EDAM; CGP-30694; CGP30694; CGP30694; D 03942; D-03942; D03942. CAS No. 80576-83-6. Molecular formula: C22H25N7O5. Mole weight: 467.49. | |
| Folinic acid | Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate. It is a 5-formyl derivative of tetrahydrofolic acid and readily converted to other reduced folic acid derivatives, thus, has vitamin activity that is equivalent to that of folic acid. Since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate. Synonyms: leucovorin. Grades: >98%. CAS No. 58-05-9. Molecular formula: C20H23N7O7. Mole weight: 473.44. | |
| Folinic acid calcium salt | Folinic acid calcium salt offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. Calcium folinate is also used in mutagenisis and cancer research. Applications: A compound that reduces the effect of folic acid antagonists. Group: Coenzymes. Synonyms: Leucovorin calcium salt; Citrovorum factor calcium salt; Calcium folinate. CAS No. 1492-18-8. Purity: ≥98%. Mole weight: 511.5. Appearance: Powder. Form: Solid. Leucovorin calcium salt; Citrovorum factor calcium salt; Calcium folinate; Folinic acid calcium salt; 1492-18-8. Cat No: COEC-033. | |
| Leucovorin Calcium | leucovorin calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Synonyms: IST5-002; IST5 002; IST5002; Benzyl-AMP; N6-Benzyladenosine-5'-phosphate; Folinic acid calcium salt; Calcium Folinate. Grades: >98%. CAS No. 1492-18-8. Molecular formula: C20H21N7O7.Ca. Mole weight: 513.52. | |
| Methotrexate | Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Amethopterin; CL14377; WR19039. CAS No. 59-05-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-14519. | |
| Methotrexate disodium | Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia). Synonyms: Amethopterin Sodium; Methotrexate Lederle; Metoart; Metotrexato Lederle; Sodium Methotrexate; N-[4-[[ (2, 4-Diamino-6-pteridinyl) methyl]methylamino]benzoyl]-L-glutamic Acid Disodium Salt; 4-amino-n(sup10)-methyl pteroyl glutamic acid disodium salt; amethopterin sodium. Grades: >98.0%. CAS No. 7413-34-5. Molecular formula: C20H20N8Na2O5. Mole weight: 498.40. | |
| Ormetoprim | It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial. Group: Biochemicals. Alternative Names: 2, 4-Diamino-5- (6-methylveratryl) pyrimidine; 2, 4-Diamino-5-92-methyl-4, 5-dimethoxybenzyl) pyrimidine; Diamino-5- (6-methylveratryl) pyrimidine; NSC 95072; Ormethoprim; Ro 5-9754. Grades: Highly Purified. CAS No. 6981-18-6. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| PD 130883 | This active molecular is a potent lipophilic quinazoline antifolate and data show that marked PD130883 suppression of thymidylate synthase slows the rate but not the extent of tetrahydrofolate cofactor interconversion to dihydrofolate upon complete suppression of dihydrofolate reductase with trimetrexate. Synonyms: CHEMBL62769;123685-36-9;2-Amino-6-(((4-nitrophenyl)-2-propynylamino)methyl)-4(3H)quinazolinone;4(3H)-Quinazolinone,2-amino-6-[[(4-nitrophenyl)-2-propyn-1-ylamino]methyl]-;ACMC-20mqpf;PD-130883; PD130883; PD 130883. Grades: 95%. CAS No. 123685-36-9. Molecular formula: C18H15N5O3. Mole weight: 349.34. | |
| Pemetrexed | Pemetrexed (LY231514) is an antifolate , the K i values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase ( TS ), dihydrofolate reductase ( DHFR ), and glycinamide ribonucleotide formyltransferase ( GARFT ), respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514. CAS No. 137281-23-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10820. | |
| Pemetrexed disodium | Pemetrexed disodium (LY231514 disodium) is an antifolate, the K i s of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514 disodium. CAS No. 150399-23-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-10820A. | |
| Pemetrexed disodium heptahydrate | Pemetrexed disodium heptahydrate is a novel antifolate , the K i values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase ( TS ), dihydrofolate reductase ( DHFR ), and glycinamide ribonucleotide formyltransferase ( GARFT ), respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514 disodium heptahydrate. CAS No. 357166-29-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10820B. | |
| Pemetrexed, Disodium Salt, Heptahydrate (N-[4-[(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium, LY-231514, Alimta) | Pemetrexed inhibits dihydrofolate reductase, thymidylate synthase and glycinamide ribonucleotide formyltransferase with Ki values of 7nM, 109nM and 9.3uM, respectively. Group: Biochemicals. Grades: Highly Purified. CAS No. 357166-29-1. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| Pralatrexate | Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor with a K i of 13.4 pM. Pralatrexate is a substrate for folylpolyglutamate synthetase with improved cellular uptake and retention. Pralatrexate has antitumor activities and has the potential for relapsed/refractory T-cell lymphoma treatment [1] [2] [3] [4]. Pralatrexate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 146464-95-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10446. | |
| Proguanil | Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase ( DHFR ) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 500-92-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B0806. | |
| Proguanil hydrochloride | Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase ( DHFR ) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 637-32-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0806A. | |
| Proguanil hydrochloride | Proguanil hydrochloride, an antimalarial prodrug, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor. Uses: Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug. Group: Solvents. Alternative Names: Chlorguanide, N1- (4-Chlorophenyl) -N5-isopropylbiguanide, Proguanil hydrochloride. CAS No. 637-32-1. Molecular formula: C11H17Cl2N5. Mole weight: 290.19. IUPACName: hydrogen 1- ({amino[ (4-chlorophenyl) amino]methylidene}amino) -N'- (propan-2-yl) methanimidamide chloride. Canonical SMILES: [H+]. [Cl-]. CC(C)N=C(N)N=C(N)NC1=CC=C(Cl)C=C1. ECNumber: 211-283-7. Catalog: ACM637321. |  |
| pteridine reductase | The enzyme from Leishmania (both amastigote and promastigote forms) catalyses the reduction by NADPH of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms. It also catalyses the reduction of 7,8-dihydropterins and 7,8-dihydrofolate to their tetrahydro forms. In contrast to EC 1.5.1.3 (dihydrofolate reductase) and EC 1.5.1.34 (6,7-dihydropteridine reductase), pteridine reductase will not catalyse the reduction of the quinonoid form of dihydrobiopterin. The enzyme is specific for NADPH; no activity has been detected with NADH. It also differs from EC 1.5.1.3 (dihydrofolate reductase) in being specific for the Si-face of NADPH. Group: Enzymes. Synonyms: PTR1; pteridine reductase 1. Enzyme Commission Number: EC 1.5.1.33. CAS No. 131384-61-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1515; pteridine reductase; EC 1.5.1.33; 131384-61-7; PTR1; pteridine reductase 1. Cat No: EXWM-1515. | |
| Pyrimethamine | Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial. Group: Biochemicals. Alternative Names: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine; 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine; Chloridin; Chloridine; Daraprim; Khloridin; Malocide; Pirimecidan; Pirimetmin; NSC 3061; RP 4753. Grades: Highly Purified. CAS No. 58-14-0. Pack Sizes: 100mg, 500mg, 1g. Molecular Formula: C12H13ClN4. US Biological Life Sciences. | Worldwide |
| Pyrimethamine | Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic - folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pirimecidan; Pirimetamin; RP 4753. CAS No. 58-14-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-18062. | |
| Pyrimethamine-d3 | Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial. Group: Biochemicals. Alternative Names: 5-(4-Chlorophenyl)-6-ethyl-d3-2,4-pyrimidinediamine; 2,4-Diamino-5-(4-chlorophenyl)-6-ethyl-d3-pyrimidine; Chloridin-d3; Chloridine-d3; Malocide-d3; Pirimecidan-d3; Pirimetamin-d3; NSC 3061-d3; RP 4753-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| SDDC-0001190 | SDDC-0001190 is an inhibitor of dihydrofolate reductase (DHFR) uesd for the treatment of Mycobacterium tuberculosis (MTB). In a previous study, SDDC-0001190 showed high selectivity, low toxicity as well as decent pharmacokinetics with half-life 3.1 h and bioavailability 26%. Uses: The treatment of mycobacterium tuberculosis (mtb). Synonyms: SDDC 0001190; SDDC0001190. | |
| Sodium 4-aminosalicylate dihydrate | Sodium 4-aminosalicylate (Sodium para-Aminosalicylic acid) dihydrate is para-aminosalicylic acid (PAS), a dihydrofolate reductase ( DHFR ) inhibitor and antituberculous agent. PAS is incorporated into the folate pathway via dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate the hydroxydihydrofolate antimetabolite, which in turn inhibits DHFR enzyme activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Aminosalicylic acid sodium salt dihydrate. CAS No. 6018-19-5. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-I0447A. | |
| Talotrexin ammonium | Talotrexin ammonium is the ammonium salt of an antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis, and cell division. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance. Synonyms: PT-523; PT 523; PT523; NSC 712783; NSC712783; NSC-712783; N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine. CAS No. 648420-92-2. Molecular formula: C28H34N10O6. Mole weight: 590.60. | |
| Trimethoprim | Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 738-70-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g. Product ID: HY-B0510. | |
| Trimethoprim | Trimethoprim is a bacteriostatic antibiotic used mainly in the prophylaxis and treatment of urinary tract infections. It caused induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. It binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). Uses: Anti-infective agents, urinary; antimalarials; antimetabolites; folic acid antagonists. Synonyms: Trimpex; Proloprim. Grades: >98%. CAS No. 738-70-5. Molecular formula: C14H18N4O3. Mole weight: 290.32. | |
| Trimethoprim Impurity B | 5-(3,4,5-Trimethoxybenzoyl)-2,4-pyrimidinediamine, a derivative of Trimethoprim, has potential for use in treating Cryptosporidiosis as an inhibitor of dihydrofolate reductase. Synonyms: 5-(3,4,5-Trimethoxybenzoyl)-2,4-pyrimidinediamine; (2,4-Diamino-5-pyrimidinyl)(3,4,5-trimethoxyphenyl)methanone; 2,4-Diamino-5-pyrimidinyl 3,4,5-trimethoxyphenylketone; Trimethoprim Related Compound B. CAS No. 30806-86-1. Molecular formula: C14H16N4O4. Mole weight: 304.31. | |
| Trimethoprim Impurity F | 3-Desmethoxy-3-bromo Trimethoprim is an impurity of Trimethoprim that inhibits the enzyme dihydrofolate reductase. Synonyms: 3-Desmethoxy-3-bromo Trimethoprim; 5-[(3-Bromo-4,5-dimethoxyphenyl)methyl]-2,4-diaminopyrimidine; 2,4-Diamino-5-(5-bromoveratryl)pyrimidine; 2,4-Diamino-5-(3,4-dimethoxy-5-bromobenzyl)pyrimidine; 2,4-Diamino-5-(3-bromo-4,5-dimethoxybenzyl)pyrimidine; 5-(3'-Bromo-4',5'-dimethoxybenzyl)-2,4-diaminopyrimidine. CAS No. 16285-82-8. Molecular formula: C13H15BrN4O2. Mole weight: 339.19. | |
| Trimethoprim lactate | Trimethoprim lactate is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactate is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim lactate has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim lactate can inhibit infection of Influenza A virus in chick embryo when combinated with zinc [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 23256-42-0. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-B0510C. | |
| Trimethoprim lactate | Trimethoprim lactate is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactate is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim lactate has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim lactate can inhibit infection of Influenza A virus in chick embryo when combinated with zinc. Group: Inhibitors. CAS No. 23256-42-0. Molecular formula: C14H18N4O3?C3H6O3. Mole weight: 380.4. Appearance: Solid. Purity: 0.98. Canonical SMILES: CC (O)C (O)=O. NC1=NC=C (CC2=CC (OC)=C (OC)C (OC)=C2)C (N)=N1. Catalog: ACM23256420. | |
| Trimethoprim lactate | Trimethoprim lactate salt is used as an antibacterial agent, primarily active against most gram-negative and gram-positive aerobic bacteria. It inhibits dihydrofolate reductase. Synonyms: Trimethoprim lactic Acid. Grades: ≥98%. CAS No. 23256-42-0. Molecular formula: C17H24N4O6. Mole weight: 380.39. | |
| Trimethoprim (Standard) | Trimethoprim (Standard) is the analytical standard of Trimethoprim. This product is intended for research and analytical applications. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 738-70-5. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-B0510R. | |
| Trimetrexate | Trimetrexate (CI-898) is an antibiotic , also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC 50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI-898. CAS No. 52128-35-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-10373. | |
| Trimetrexate | Trimetrexate is a potent competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase. Synonyms: CI-898; CI 898; CI898. Grades: >98%. CAS No. 52128-35-5. Molecular formula: C19H23N5O3. Mole weight: 369.42. | |
| Trimetrexate glucuronate | Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI-898 glucuronate. CAS No. 82952-64-5. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-103396. | |
| WR99210 | WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains (including Pyrimethamine (HY-18062)-resistant P. falciparum strains) as well as T. gondii. Group: Inhibitors. Alternative Names: 1,6-Dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-2,4-diamine. CAS No. 47326-86-3. Molecular formula: C14H18Cl3N5O2. Mole weight: 394.68. Appearance: Solid. Purity: 0.96. IUPACName: 6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-2,4-diamine. Canonical SMILES: CC1 (N=C (N=C (N1OCCCOC2=C (C=C (C (Cl)=C2)Cl)Cl)N)N)C. Catalog: ACM47326863. | |
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