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Bifunctional DOTA aconjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and therapeutic radiopharmaceuticals. Group: Biochemicals. Alternative Names: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid; 1,4,7,10-Tetra(carboxymethyl)-1,4,7,10-tetraazacyclododecane; 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid; DOTA; NSC 681107; Tetraxetan. Grades: Highly Purified. CAS No. 60239-18-1. Pack Sizes: 100mg, 250mg, 500mg. US Biological Life Sciences.
Worldwide
DOTA(allyl ester)3
DOTA(allyl ester)3, a protected DOTA derivative, is used for coupling to acid- or base-sensitive compounds. Synonyms: DOTA(OAll)3; 4,7,10-Tri-(allyloxycarbonylmethyl)-1,4,7,10-tetraazacyclododecan-1-yl-acetic acid; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid 1,4,7-triallyl ester; 2-(4,7,10-tris(2-(allyloxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetic acid; {4,7,10-Tris[2-(allyloxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododecan-1-yl}acetic acid. Molecular formula: C25H40N4O8. Mole weight: 524.61.
DOTA derivative
DOTA derivative is a benxyl derivative of the cyclic tosamide; can be nitrated directly; is more convenient to incorporate the nitro group after deprotection lithium aluminum hydride. Synonyms: DOTA derivative. Grades: >98%. CAS No. 153777-70-9. Molecular formula: C43H50N4O8S4. Mole weight: 879.14.
DOTA-NOC is a potent chelating agent extensively used in radiopharmaceuticals for the targeted imaging and therapy of neuroendocrine tumors. By combining with diverse radiometals, such as lutetium-177 or yttrium-90, it generates therapeutic agents that specifically bind to neuroendocrine tumor cells. The DOTA-NOC derivatives have displayed remarkable specificity and affinity for somatostatin receptors, endowing it with a unique potential for cancer therapy. Its diverse applications stem from its impressive properties, which include high burstiness in sentence structure and an elevated level of perplexity in its descriptions. Synonyms: DOTA-[Nal3]-octreotide; L-Cysteinamide, N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-. Grades: 95%. CAS No. 619300-53-7. Molecular formula: C69H94N14O17S2. Mole weight: 1455.7.
DOTAP
DOTAP is a cationic lipid structure, used for in vitro and in vivo nucleic acid and protein delivery. DOTAP is a good immunomodulator, the antigen presenting capacity of antigen presenting cells can be obviously improved by preparing cationic liposome by packaging polypeptide or protein antigens and the DOTAP, and the DOTAP can activate the antigen presenting cells through a mitogen-activated protein kinase (MAP) pathway to induce specific immune response, unlike the traditional adjuvant which activates the antigen presenting cells through a Toll-like receptor pathway. Synonyms: 1,2-Dioleoyloxy-3-(trimethylammonium)propane; 1,2-Dotap; N,N,N-Trimethyl-2,3-bis((-1-oxo-octadecenyl)oxy)-(Z,Z)-1-propanaminium; N,N,N-Trimethyl-2,3-bis(oleoyloxy)propan-1-aminium. CAS No. 113669-21-9. Molecular formula: C42H80NO4. Mole weight: 663.09.
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1,2-Dioleoyl-3-trimethylammonium-propane chloride. CAS No. 132172-61-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 250 mg. Product ID: HY-112754A.
DOTAP:Chol (50:50) Liposomes
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
DOTAP:Chol:DOPE (10:75:5) Liposomes
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
This product is a positively charged PEGylated ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
DOTAP:DOPC (1:99)-ATP Liposome
This product is a positively charged ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
DOTAP:DOPC (20:80)-ATP Liposome
This product is a positively charged ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
DOTAP:DOPC (5:95)-ATP Liposome
This product is a positively charged ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
This product is a positively charged PEGylated ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
This product is a positively charged PEGylated ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
This product is a positively charged PEGylated ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
This product is a positively charged PEGylated ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
This product is a positively charged PEGylated ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
This product is a positively charged PEGylated ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
This product is a positively charged PEGylated ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
This product is a positively charged PEGylated ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
This product is a positively charged PEGylated ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
DOTAP:DOPE (50:50) Liposomes
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
DOTAP Liposomes
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
DOTAP mesylate
DOTAP mesylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 252769-92-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W127426.
DOTAP methylsulfate
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate. CAS No. 144189-73-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg. Product ID: HY-W127378.
DOTAP:PC:Chol (10:60:30)-ATP Liposome
This product is a positively charged ATP liposome. Adenosine triphosphate (ATP) is the direct energy source required for all cellular life activities. Encapsulating it within liposomes prevents enzymatic hydrolysis, prolongs circulation time, and significantly enhances its therapeutic efficacy. Due to the instability of ATP, this product is in the form of lyophilized powder. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
Dotarizine
Dotarizine. Group: Biochemicals. Alternative Names: 1-(Diphenylmethyl)-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine; FI-6026. Grades: Highly Purified. CAS No. 84625-59-2. Pack Sizes: 50mg, 100mg. Molecular Formula: C29H34N2O2. US Biological Life Sciences.
Antimigraine. Group: Biochemicals. Alternative Names: 1-(Diphenylmethyl)-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine; FI-6026. Grades: Highly Purified. CAS No. 84625-59-2. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
DOTATATE
DOTATATE is a DOTA-conjugated peptide. DOTATATE can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT) [1] [2] [3] [4]. DOTATATE can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Group: Peptides. CAS No. 177943-88-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-106244.
DOTATATE acetate
DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT) [1] [2] [3] [4]. DOTATATE (acetate) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Group: Peptides. CAS No. 177943-89-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106244A.
DOTA-tris(tBu)ester NHS ester
DOTA-tris(tBu)ester NHS ester is a derivative of DOTA for the labeling of peptides and antibodies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 819869-77-7. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-131326.
DOTA-tri(t-butyl ester) can be used in the synthesis of generations 3 (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents for MR angiography and tumor angiogenesis imaging [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 137076-54-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W034551.
DOTA-[Tyr3]-Octreotide Acid
DOTA-TATE, DOTATATE or DOTA-octreotate is a substance which, when bound to various radionuclides, has been tested for the treatment and diagnosis of certain types of cancer, mainly neuroendocrine tumours. Synonyms: DOTATATE; DOTA-(Tyr3,Thr8)-Octreotide; DOTA-[Tyr3] Octreotide Acid (Octreotate); 4,7,10-Tricarboxymethyl-1,4,7,10-tetraaza-cyclododecan-1-yl-acetyl-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-OH acetate salt (Disulfide bond). Grades: 98%. CAS No. 177943-89-4. Molecular formula: C65H90N14O19S2. Mole weight: 1435.63.
0.5% DiI Encapsulated DOTAP Liposomes
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
0.5% DiO Encapsulated DOTAP Liposomes
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
10-Descarboxymethyl-10-[2-[ (diphosphonomethyl) amino) -2-oxoethyl]-DOTA is used in the preparation and biodistribution assessment of 111n-BPAMD as novel agent for bone SPECT imaging. Group: Biochemicals. Grades: Highly Purified. CAS No. 872469-60-8. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C17H33N5O13P2, Molecular Weight: 577.419999999999. US Biological Life Sciences.
Worldwide
3-Azidopropyl thioureidobenzyl DOTA
3-Azidopropyl thioureidobenzyl DOTA is a bifunctional molecule, which can be conjugated to monoclonal antibody (mAb) and also chelate metal ion for radioimmunotherapy and PET imaging (immuno-PET). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C27H41N9O8S, Molecular Weight: 651.73. US Biological Life Sciences.
Worldwide
Aminobutyl-DOTA-tris(t-butyl ester)
Aminobutyl-DOTA-tris(t-butyl ester) is a bifunctional chelating agent. Synonyms: Tri-tert-butyl 2,2',2''-(10-(2-((4-aminobutyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate; 1,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl acetate)-10-(4-aminobutyl)acetamide. CAS No. 1402393-59-2. Molecular formula: C32H62N6O7. Mole weight: 642.87.
Bifunctional DOTA derivatives and their conjugation to peptides has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and therapeutic radiopharmaceuticals. Group: Biochemicals. Alternative Names: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid Europium Sodium Salt Hydrate; Europium 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic Acid Sodium Salt Hydrate; Eu-DOTA; NSC 681107-Eu; Eu-Tetraxetan Sodium Salt Hydrate. Grades: Highly Purified. CAS No. Free Acid: 60239-18-1. Pack Sizes: 10mg. Molecular Formula: C??H??EuN?NaO? xH?O. US Biological Life Sciences.
Worldwide
Fluorescein-triazole-PEG5-DOTA
Fluorescein-triazole-PEG5-DOTA. Uses: For industrial and laboratory use. Product Category: Fluorescein-PEG. Molecular formula: C67H79N11O18S. Mole weight: 1358.5 g/mol. Purity: 0.98. Product ID: DYE-FLU-0079. Alfa Chemistry ISO 9001:2015 Certified.
Iron DOTA Sodium Salt Pentahydrate
Fe(III) complexes of macrocyclic amino carboxylates. Group: Biochemicals. Alternative Names: Sodium (TPS-7-2-134542)-[1, 4, 7, 10-Tetraazacyclododecane-1, 4, 7, 10-tetraacetato(4-)-N1, N4, N7, N10, O1, O4, O7]ferrate(1-). Grades: Highly Purified. CAS No. 149819-85-2. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
(S)-p-SCN-Bn-DOTA
(S)-p-SCN-Bn-DOTAis a bifunctional chelator ( Bifunctional Chelator ; BFC ) and a macrocyclic DOTA derivative used for tumor pre-targeting. (S)-p-SCN-Bn-DOTA can be used for conjugation of peptides and radionuclides. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 1020407-41-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156038.
1,2-dioleoyloxy-3-(trimethylammonium)propane (DOTAP) chloride has been used for the preparation of cationic liposome and liposome-DNA complex. It has also been used to assess tumor necrosis factor α (TNF-α) production. Synonyms: Dotap chloride; DOTAP-Cl; DOTAP (chloride); 1-Propanaminium, N,N,N-trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecenyl]oxy]-, chloride (1:1); 1,2-Dioleoyl-3-trimethylammonium-propane, Chloride; (+/-)-Dotap chloride; Dotap chloride, (+/-)-; N-(1-(2,3-Dioleoyloxy)propyl)-N,N,N-trimethylammonium chloride; (2,3-dioleoyloxy-propyl)-trimethylammonium-chloride; 18:1 TAP (DOTAP), 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt), chloroform; DOTAP Chloride; N,N,N-Trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecenyl]oxy]-1-propanaminium; 2,3-di(octadec-9-enoyloxy)propyl-trimethylazanium. Grades: >98% by HPLC. CAS No. 132172-61-3. Molecular formula: C42H80ClNO4. Mole weight: 698.54.
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid. Uses: Bifunctional dota aconjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted mri contrast agents and diagnostic and ther apeutic radiopharmaceuticals. Group: Macrocyclessupramolecular host materials. Alternative Names: J-650232; AJ-80871; MFCD00068657; CHEBI:61028; LS-187777; CS-0046228; 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid; ZINC22059268; BCP13075; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid Europium. CAS No. 60239-18-1. Product ID: 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid. Molecular formula: 404.42g/mol. Mole weight: C16H28N4O8. C1CN (CCN (CCN (CCN1CC (=O)O)CC (=O)O)CC (=O)O)CC (=O)O. InChI=1S/C16H28N4O8/c21-13 (22)9-17-1-2-18 (10-14 (23)24)5-6-20 (12-16 (27)28)8-7-19 (4-3-17)11-15 (25)26/h1-12H2, (H, 21, 22) (H, 23, 24) (H, 25, 26) (H, 27, 28). WDLRUFUQRNWCPK-UHFFFAOYSA-N.
DO3A tert-Butyl ester
DOTA tert-Butyl ester is a benxyl derivative of the cyclic tosamide; can be nitrated directly; is more convenient to incorporate the nitro group after deprotection lithium aluminum hydride. Synonyms: Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7-triacetate; DO3A-t-Bu-ester; 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic Acid Tri-tert-butyl Ester. Grades: >98%. CAS No. 122555-91-3. Molecular formula: C26H50N4O6. Mole weight: 514.70.
DPI-4452
DPI-4452 is a CAIX -targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets ( IC 50 for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models [1]. DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Group: Peptides. CAS No. 2941391-49-5. Pack Sizes: 1 mg. Product ID: HY-P10761.
Edotreotide
Edotreotide is a somatostatin analogue. Edotreotide bound to various radionuclides, has the potential for the research and diagnosis of certain types of cancer [1]. Edotreotide can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Group: Peptides. Alternative Names: DOTATOC; SDZ-SMT 487; SMT 487. CAS No. 204318-14-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106033.
Edotreotide
Edotreotide is a substance used in the treatment and diagnosis of certain types of cancer. Synonyms: DOTA-(Tyr3)-Octreotide; SMT-487; SMT 487; SMT487; DOTA-d-Phe1-Tyr3-octreotide; DOTA-TOC; DOTA0-Tyr3-octreotide; DOTATOC; [Tyr3]-octreotide; DOTA-TOC; DOTA-tyr(3)-octreotide; DOTATOC. Grades: 98%. CAS No. 204318-14-9. Molecular formula: C65H92N14O18S2. Mole weight: 1421.64.
Fmoc-D-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as DOTA-modified peptides and their metal chelates with cancer diagnostic effects [1]. Uses: Scientific research. Group: Peptides. CAS No. 198544-42-2. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W046355.
Gadobutrol Impurity 1
Gadobutrol Impurity 1 is an impurity of Gadobutrol, which is a nonionic, paramagnetic contrast agent developed for tissue contrast enhancement in magnetic resonance imaging (MRI). Uses: Chelating agents. Synonyms: DOTA; Tetraxetan; 60239-18-1; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid; Dota acid; 1,4,7,10-Dota; 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid; 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid; CHEBI:61028; DOT-A; 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid; MFCD00068657; NSC-681107; 1HTE449DGZ; MLS001333612; Tetraxetan (USAN); NSC681107; 2,2',2',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetraacetic acid; SMR000857276; TETRAXETAN [USAN]; 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid; UNII-1HTE449DGZ; tetraxetanum; gadoterate-meglumine; 1,4,7,10-Tetraazacyclododecane- 1,4,7,10-tetraacetic-acid; Gadobutrol impurity 1. Grades: > 95%. Molecular formula: C18H34N4O9. Mole weight: 450.49.
Gadobutrol Impurity 4
Gadobutrol Impurity 4 is an impurity of Gadobutrol, which is a nonionic, paramagnetic contrast agent developed for tissue contrast enhancement in magnetic resonance imaging (MRI). Synonyms: Gd-DOTA. Grades: > 95%. Molecular formula: C12H24N4O4. Mole weight: 288.35.
Gadobutrol Impurity 9
Gadobutrol Impurity 9 is an impurity of Gadobutrol, which is a nonionic, paramagnetic contrast agent developed for tissue contrast enhancement in magnetic resonance imaging (MRI). Synonyms: DOTA; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid; 1,4,7,10-Tetra(carboxymethyl)-1,4,7,10-tetraazacyclododecane; 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid; NSC 681107; Tetraxetan. Grades: > 95 %. CAS No. 60239-18-1. Molecular formula: C16H28N4O8. Mole weight: 404.42.
Gadoterate meglumine
Gadoterate meglumine (Gd-DOTA) is a non-specific paramagnetic gadolinium complex used as a contrast enhancer in magnetic resonance imaging (MRI). Gadoterate meglumine, as a contrast agent in MRI, is able to shorten the longitudinal relaxation time (T1) of tissue, resulting in a brighter signal in MRI images. Gadoterate meglumine can be used for the study of the central nervous system (such as the brain and spinal cord), abdominal, pelvic organs, breast, bone and joint imaging, angiography, and cardiac electrophysiology [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Gd-DOTA; Magnescope; P-449. CAS No. 92943-93-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108760.
Gadoteric acid
Gadoteric acid is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA). It is used for imaging of blood vessels. Synonyms: Gadoterate; DOTA-Gd; Gd-Dota; Gadolinium 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid. Grades: 95%. CAS No. 72573-82-1. Molecular formula: C16H25GdN4O8. Mole weight: 558.65.
H-Glu[cyclo(-Arg-Gly-Asp-D-Phe-Lys)]-cyclo(-Arg-Gly-Asp-D-Phe-Lys) is the dimeric form of c(RGDfK), which has better tumor-targeting properties than the monomer. It binds readily to dyes, drug molecules, or chelators. The 68Ga complex of DOTA-E(c(RGDfK))2 has been evaluated as a therapeutic radiopharmaceutical. Synonyms: Cyclo[D-Phe-N6-[N5-[3-[[cyclo(L-Ala-L-Arg-Gly-L-Asp-D-Phe-)]-3-yl]propyl]-L-Gln-]-L-Lys-L-Arg-Gly-L-Asp-]; E(c(RGDfK))2; SU 016. Grades: ≥95%. CAS No. 250612-47-6. Molecular formula: C59H87N19O16. Mole weight: 1318.44.
S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: p-SCN-Bn-DOTA. Appearance: Solid. CAS No. 127985-74-4. Molecular formula: C24H33N5O8S·2.5HCl·2.5H2O. Mole weight: 687.8. Purity: 0.94. Product ID: ACM127985744. Alfa Chemistry ISO 9001:2015 Certified.
Vipivotide tetraxetan (PSMA-617) is a high potent prostate-specific membrane antigen (PSMA) inhibitor, with a K i of 0.37 nM. Vipivotide tetraxetan (PSMA-617) is designed consisting of three components: the pharmacophore Glutamate-urea-Lysine, the chelator DOTA able to complex both 68Ga or 177Lu, and a linker connecting these two entities. Glutamate-urea-Lysine is the selective pharmacophore to bind to prostate specific membrane antigen. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PSMA-617. CAS No. 1702967-37-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-117410.
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