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| Product | Description | |
|---|---|---|
| Elastase | Elastase. Synonyms: EC 3.4.21.36;EC 3.4.21.37;ELASTASE, LEUKOCYTE;ELASTASE, NEUTROPHIL, HUMAN;ELASTASE, HUMAN NEUTROPHIL;ELASTASE, HUMAN NEUTROPHILS;Elastase, pancreatic from porcine pancreas, 30 units/mg;Elastase froM porcine pancreas Min. 200 U/Mg lyophil. salt-free. CAS No. 39445-21-1. Pack Sizes: 1 g. Product ID: CDF4-0039. Category: Enzyme Preparations. Product Keywords: Food Ingredients; Enzyme Preparations; Elastase; CDF4-0039; 39445-21-1; 254-453-6; 39445-21-1. Purity: 0.99. Color: White. EC Number: 254-453-6. Physical State: Lyophilized Powder. Solubility: H2O: soluble. Storage: -20°C. |  |
| Elastase, Human leukocytes | Elastase, Human leukocytes is a serine protease present in the nitrogen-loving granules of neutrophils. Elastase, Human leukocytes potential substrates include almost all components of the extracellular matrix, as well as a variety of proteins such as coagulation factors, complement, immunoglobulins and cytokines. It has a strong proteolytic function and participates in the pathogenesis of inflammatory tissue damage [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9004-6-2. Pack Sizes: 1 U. Product ID: HY-P2751. |  |
| Elastase, Human Neutrophil | Elastase, Human Neutrophil, CAS 9004-06-2, is a serine protease that degrades elastin, collagen, and proteoglycans. Group: Fluorescence/luminescence spectroscopy. |  |
| Elastase Inhibitor II | The Elastase Inhibitor II controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| Elastase Inhibitor III | The Elastase Inhibitor III controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| Elastase Inhibitor IV - CAS 127373-66-4 | The Elastase Inhibitor IV, also referenced under CAS 127373-66-4, controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| Elastase Inhibitor V (2-(2-Bromophenyl)-5-chloro-3,1-benzoxazin-4-one) | A benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5nM), likely by covalently modifying active site serine. Shown to inhibit elastase secretion (IC50 = 80.8nM), but not O2 - generation, in fLMP-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1mg/kg, i.v.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| Elastase, Porcine pancreas | Elastase, Porcine pancreas (EC 3.4.21.36) is a single polypeptide chain of 240 amino acid residues, derived from pig pancreas. Elastase, Porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EC 3.4.21.36; Pancreatopeptidase E. CAS No. 39445-21-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P2974. | |
| Elastase Substrate I, Colorimetric - CAS 70967-90-7 | A specific chromogenic substrate for human neutrophil elastase. Group: Fluorescence/luminescence spectroscopy. | |
| Elastase Substrate IV, Colorimetric | A specific substrate for pancreatic elastase. Group: Fluorescence/luminescence spectroscopy. | |
| Elastase Substrate V, Fluorogenic - CAS 72252-90-5 | Elastase Substrate V, Fluorogenic, CAS 72252-90-5, is a sensitive fluorogenic substrate for the quantitative determination of human leukocyte and porcine pancreatic elastase (Km = 140 μM). Group: Fluorescence/luminescence spectroscopy. | |
| Elastase Substrate VIII, Colorimetric - CAS 52299-14-6 | Substrate for the spectrophotometric assay of elastase. Group: Fluorescence/luminescence spectroscopy. | |
| Immobilized porcine pancreatic elastase | Cleaves PAI-1 between the P3 and P4 residues to create a loop-inserted species that is non-inhibitory towards the target enzymes uPA and tPA. Group: Enzymes. Synonyms: EC 3. 4. 21. 36, pancreatopeptidase E; pancreatic elastase I; elastase; elaszym; serine elastase; elastase-1; pancreatopeptidase; ELA1. Enzyme Commission Number: EC 3. 4. 21. 36. Purity: >95% by SDS-PAGE analysis. Stability: 12 months from delivery. Storage: 4°C. Form: Resin. Source: Porcine pancreas. Species: Porcine. EC 3. 4. 21. 36, pancreatopeptidase E; pancreatic elastase I; elastase; elaszym; serine elastase; elastase-1; pancreatopeptidase; ELA1; Immobilized elastase; Immobilized pancreatic elastase; Immobilized ELA1. Cat No: NATE-1760. |  |
| leukocyte elastase | Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11. Group: Enzymes. Synonyms: lysosomal elastase; neutrophil elastase; polymorphonuclear leukocyte elastase; elastase; elaszym; serine elastase; lysosomal elastase; granulocyte elastase. Enzyme Commission Number: EC 3.4.21.37. CAS No. 9004-6-2. ELA2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4131; leukocyte elastase; EC 3.4.21.37; 9004-06-2; lysosomal elastase; neutrophil elastase; polymorphonuclear leukocyte elastase; elastase; elaszym; serine elastase; lysosomal elastase; granulocyte elastase. Cat No: EXWM-4131. | |
| macrophage elastase | This enzyme is synthesized as a proenzyme of 53 kDa that is converted to an active form of 22 kDa. cDNA sequences have been obtained for the mouse and human enzymes. In peptidase family M10 (interstitial collagenase family). Group: Enzymes. Synonyms: metalloelastase; human macrophage metalloelastase (HME). Enzyme Commission Number: EC 3.4.24.65. CAS No. 9004-6-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4348; macrophage elastase; EC 3.4.24.65; 9004-06-2; metalloelastase; human macrophage metalloelastase (HME). Cat No: EXWM-4348. | |
| Native Human Elastase | Neutrophil elastase is a serine proteinase in the same family as chymotrypsin and has broad substrate specificity. Secreted by neutrophils and macrophages during inflammation, it destroys bacteria and host tissue. It also localizes to Neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases. Leuk ocyte elastase is a 29 kda serine endoprotease of the proteinase s1 family. it exists as a single 238 amino acid-peptide chain with four disulfide bonds. it contains two or thee n-linked glycans of variable composition which account for its three major isoforms. Applications: Elastase from creative enzymes has been used to digest fibro...mal models. Group: Enzymes. Synonyms: ELANE; elastase; EC 3.4.21.37; leukocyte elastase; ELA2; elastase 2; neutrophil elaszym; serine elastase; lysosomal elastase; neutrophil elastase; polymorphonuclear leukocyte elastase; elaszym; granulocyte elastase. Enzyme Commission Number: EC 3.4.21.37. CAS No. 9004-6-2. ELA2. Mole weight: 29 kDa. Activity: > 50 units/mg protein (Bradford). Storage: -20°C. Form: Lyophilized from 0.05 M sodium acetate (pH 5.5) and 0.6 M NaCl. Source: Human leuk ocytes. Species: Human. ELANE; elastase; EC 3.4.21.37; leukocyte elastase; ELA2; elastase 2; neutrophil elaszym; serine elastase; lysosomal elastase; neutrophil elastase; polymorphonuclear leukocyte ela | |
| Native Porcine Elastase | Pancreatic elastase is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an inactive zymogen and later activated in the duodenum by trypsin. Elastases form a subfamily of serine proteases, characterized by a distinctive structure consisting of two beta barrel domains converging at the active site that hydrolyze amides and esters amongst many proteins in addition to elastin, a type of connective tissue that holds organs together. Pancreatic elastase 1 is a serine endopeptidase, a specific type of protease that has the amino acid serine at its active site. Group: Enzymes. Synonyms: EC 3.4.21.36, pancreatopeptidase E; pancreatic elastase I; elastase; elaszym; serine elastase; elastase-1; pancreatopeptidase; ELA1. Enzyme Commission Number: EC 3.4.21.36. CAS No. 39445-21-1. ELA1. Activity: Type I, > 15 units/mg; Type II, > 4.0 units/mg protein; Type III, > 1 units/mg protein (biuret). Storage: -20°C. Form: Type I, white powder; Type II, Type III, lyophilized powder, Contains sodium carbonate. Source: Porcine pancreas. Species: Porcine. EC 3.4.21.36, pancreatopeptidase E; pancreatic elastase I; elastase; elaszym; serine elastase; elastase-1; pancreatopeptidase; ELA1. Pack: Package size based on protein content. Cat No: NATE-0211. | |
| Native Pseudomonas aeruginosa Elastase | Pancreatic elastase is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an inactive zymogen and later activated in the duodenum by trypsin. Elastases form a subfamily of serine proteases, characterized by a distinctive structure consisting of two beta barrel domains converging at the active site that hydrolyze amides and esters amongst many proteins in addition to elastin, a type of connective tissue that holds organs together. Pancreatic elastase 1 is a serine endopeptidase, a specific type of protease that has the amino acid serine at its active site. Group: Enzymes. Synonyms: EC 3.4.21.36, pancreatopeptidase E; pancreatic elastase I; elastase; elaszym; serine elastase; elastase-1; pancreatopeptidase; ELA1. Enzyme Commission Number: EC 3.4.24.26. CAS No. 9004-6-2. Purity: > 90% by SDS-PAGE. ELA1. Mole weight: 33000. Stability: Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°Cor for up to 2 months at-20°C. Appearance: Lyophilized. Storage: Storage at-20°C. Source: Pseudomonas aeruginosa. EC 3.4.21.36, pancreatopeptidase E; pancreatic elastase I; elastase; elaszym; serine elastase; elastase-1; pancreatopeptidase; ELA1. Cat No: NATE-0212. | |
| Neutrophil Elastase Inhibitor | Neutrophil elastase inhibitor is an inhibitor that selectively targets the binding domain of neutrophil elastase, a serine proteinase secreted by neutrophils and macrophages during inflammation. It is potentially used for lung disease treatment. Uses: Protease inhibitors. Synonyms: 1-(3-Methylbenzoyl)-1H-indazole-3-carbonitrile. Grades: ≥95%. CAS No. 1448314-31-5. Molecular formula: C16H11N3O. Mole weight: 261.3. |  |
| Neutrophil elastase inhibitor 1 | Neutrophil elastase inhibitor 1 (Compound 5b) is a competitive, pseudoirreversible inhibitor for neutrophil elastase with an IC 50 of 7 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1448314-31-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-118177. | |
| pancreatic elastase | Formed by activation of proelastase from mammalian pancreas by trypsin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11. Group: Enzymes. Synonyms: pancreatopeptidase E; pancreatic elastase I; elastase; elaszym; serine elastase. Enzyme Commission Number: EC 3.4.21.36. CAS No. 9004-6-2. ELA1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4130; pancreatic elastase; EC 3.4.21.36; 9004-06-2; pancreatopeptidase E; pancreatic elastase I; elastase; elaszym; serine elastase. Cat No: EXWM-4130. | |
| pancreatic elastase II | A peptidase of family S1 (trypsin family) formed by activation of proelastase II from mammalian pancreas by trypsin. Usually, only one of the pancreatic elastases (see also EC 3.4.21.36) is expressed in a given species; human pancreatic elastase is of type II. Group: Enzymes. Synonyms: pancreatic elastase 2. Enzyme Commission Number: EC 3.4.21.71. CAS No. 75603-19-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4163; pancreatic elastase II; EC 3.4.21.71; 75603-19-9; pancreatic elastase 2. Cat No: EXWM-4163. | |
| 1,1,2-Ethanetricarboxylic Acid 1,1,2-Triethyl Ester | 1,1,2-Ethanetricarboxylic Acid 1,1,2-Triethyl Ester is a useful synthetic intermediate. It can be used to prepare Isobutylsuccinic Acid (I780660) which was used to synthesize succinimide derivatives as inhibitors of human leukocyte elastase, cathepsin G and proteinase 3. Group: Biochemicals. Grades: Highly Purified. CAS No. 7459-46-3. Pack Sizes: 5g, 10g. Molecular Formula: C11H18O6. US Biological Life Sciences. | Worldwide |
| 1-Methyl-1H-indazole-6-carboxylic Acid Methyl Ester | 1-Methyl-1H-indazole-6-carboxylic Acid Methyl Ester is a useful synthetic intermediate. It is an analog of Indazole-3-carboxylic Acid Methyl Ester (I505250) which has potential as application of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase. Indazole-3-carboxylic Acid Methyl Ester (I505250) is also used in the preparation of indazole-pyridine based protain kinase/Akt inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1007219-73-9. Pack Sizes: 500mg, 5g. Molecular Formula: C10H10N2O2, Molecular Weight: 190.2. US Biological Life Sciences. | Worldwide |
| 2-Hydroxy-4-methylpyridine-d3 | 2-Hydroxy-4-methylpyridine-d3 is the isotope labelled analog of 2-Hydroxy-4-methylpyridine (H949890); an intermediate used to prepare oxobenzopyrancarboxyl ate derivatives as inhibitors of serine proteases and human leukocyte elastase. It is also used in the synthesis of (indanylamino) (pyridinyloxy) pyrazines and analogs as corticotropin releasing factor type-1 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1185316-03-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C6H4D3NO, Molecular Weight: 112.14. US Biological Life Sciences. | Worldwide |
| 2-Hydroxy-4-methylpyridine-d6 | 2-Hydroxy-4-methylpyridine-d6 is the isotope labelled analog of 2-Hydroxy-4-methylpyridine (H949890); an intermediate used to prepare oxobenzopyrancarboxyl ate derivatives as inhibitors of serine proteases and human leukocyte elastase. It is also used in the synthesis of (indanylamino) (pyridinyloxy) pyrazines and analogs as corticotropin releasing factor type-1 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 916979-13-0. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C6HD6NO, Molecular Weight: 115.16. US Biological Life Sciences. | Worldwide |
| 2-Methyl-2H-indazole-6-carboxylic Acid Methyl Ester | 2-Methyl-2H-indazole-6-carboxylic Acid Methyl Ester is a useful synthetic intermediate. It is an analog of Indazole-3-carboxylic Acid Methyl Ester (I505250) which has potential as application of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase. Indazole-3-carboxylic Acid Methyl Ester (I505250) is also used in the preparation of indazole-pyridine based protain kinase/Akt inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1071433-01-6. Pack Sizes: 500mg, 5g. Molecular Formula: C10H10N2O2, Molecular Weight: 190.2. US Biological Life Sciences. | Worldwide |
| Alvelestat | Alvelestat (AZD9668) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC 50 value of 7.9 nM, a K i value of 9.4 nM and a K d value of 9.5 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD9668. CAS No. 848141-11-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15651. | |
| Alvelestat | Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE). Synonyms: AZD9668; AZD-9668; AZD 9668; MPH966; MPH 966; MPH-966; Alvelestat. Grades: 0.98. CAS No. 848141-11-7. Molecular formula: C25H22F3N5O4S. Mole weight: 545.537. | |
| ??-Antitrypsin, Human Plasma - CAS 9041-92-3 | ??-Antitrypsin, CAS 9041-92-3, is a protease inhibitor of the serpin superfamily. Inhibits elastase, cathepsin G, and proteinase 3. Group: Fluorescence/luminescence spectroscopy. | |
| BAY 677 | BAY 677 is an inactive control for BAY 678 and a human neutrophil elastase (HNE) inhibitor. Synonyms: BAY-677; BAY 677; BAY677; 5-[(4S)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 2117404-84-7. Molecular formula: C20H15F3N4O2. Mole weight: 400.35. | |
| BAY 678 | BAY 678 is a cell-permeable human neutrophil elastase (HNE) inhibitor (IC50 = 20 nM) that displays around 2000-fold selectivity for NHE over a panel of 21 other serine proteases. Synonyms: BAY 678; BAY678; BAY-678; 5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 675103-36-3. Molecular formula: C20H15F3N4O2. Mole weight: 400.35. | |
| BAY8040 | This active molecular is a Selective Human Neutrophil Elastase Inhibitor and combines excellent potency and selectivity with a promising pharmacokinetic profile. In animal models for pulmonary arterial hypertension, BAY8040 shows the efficancy of decreasing cardiac remodeling and amelioration of cardiac function in vivo. Uses: Cardiac remodeling and amelioration of cardiac function. Synonyms: BAY8040; BAY-8040; BAY 8040; (R)-4-(7-methyl-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyridazin-4-yl)benzonitrile. Grades: 98%. CAS No. 1194453-23-0. Molecular formula: C21H16F3N5O2. Mole weight: 427.39. | |
| BAY 85-8501 | This active molecular is a highly selective neutrophil elastase inhibitor.IC50 for HNE is 0.065 nM, LipE is 7.2. BAY 85-8501 was being tested in clinical studies for the treatment of pulmonary diseases. In Feb 2013, Phase-II clinical trials in Bronchiectasis in Spain were on going. In Mar 2013, Phase-II clinical trials in Bronchiectasis in France, Germany and Italy were on going. In Jun 2014, Bayer completed a phase IIa trial in Bronchiectasis in United Kingdom, Spain, France, Germany and Italy. Uses: The treatment of pulmonary diseases. Synonyms: BAY 85-8501; BAY85-8501; BAY-85-8501; BAY 858501; BAY858501; BAY-858501. (S)-4-(4-cyano-2-(methylsulfonyl)phenyl)-3,6-dimethyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1161921-82-9. Molecular formula: C22H17F3N4O3S. Mole weight: 474.46. | |
| Cathepsin G Inhibitor I | Cathepsin G inhibitor I is a potent and selective inhibitor of cathepsin G with IC50 of 53 nM. It weakly inhibits chymotrypsin and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase. Synonyms: Cathepsin G Inhibitor I; 429676-93-7; Cathepsin G Inhibitor; CHEMBL164694; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid; SCHEMBL1613660; DTXSID80431393; BDBM50139754; HY-103351; CS-0027703; A918760; (2-{3-[(1-Benzoyl-piperidin-4-yl)-methyl-carbamoyl]-naphthalen-2-yl}-1-naphthalen-1-yl-2-oxo-ethyl)-phosphonic acid; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2 oxoethyl]phosphonic acid. Grades: ≥95%. CAS No. 429676-93-7. Molecular formula: C36H33N2O6P. Mole weight: 620.6. | |
| Chrysophanol 8-O-glucoside | Chrysophanol 8-O-glucoside, from the roots of Rumex acetosa , shows moderate elastase inhibition activity [1]. Uses: Scientific research. Group: Natural products. CAS No. 13241-28-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2395. | |
| Chymostatin | Chymostatin is a bioactive peptide that acts as a protease inhibitor with selectivity for chymotryptase-like serine proteases. It potently inhibits chymotrypsin and chymase, but it cannot block the activity of cathepsins, papain, and leukocyte elastase effectively. It doesn't have effect on trypsin, thrombin, plasmin, pepsin, and kallikrein. Uses: Serine proteinase inhibitors. Synonyms: [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-a-[2-amidohexahydro-4(S)-pyrimidyl]-(S)-glycyl-[A= Leu B=Val C=Ile]-phenylalaninal (Mixture). Grades: ≥95% (a mixture of A, B, C). CAS No. 9076-44-2. Molecular formula: CxHyN7O6. Mole weight: 607.7. | |
| DMP 777 | DMP 777(L-694458) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor. Synonyms: L-694458; L 694458; L694458; DMP-777; DMP777. Grades: >98%. CAS No. 157341-41-8. Molecular formula: C31H40N4O6. Mole weight: 564.67. | |
| EI-1941-1 | It is originally isolated from Farrowia sp. E-1941. EI-1941-1 inhibited recombinant human ICE with an IC50 of 0.086 μmol/L. It also inhibits elastase and cathepsin. Synonyms: 2,3-Dihydroxy-5-propyl-1a,5,6,7a-tetrahydro-2H-oxireno[g]isochromen-7(3H)-one. CAS No. 189828-31-7. Molecular formula: C12H16O5. Mole weight: 240.25. | |
| EI-1941-2 | It is originally isolated from Farrowia sp. E-1941. EI-1941-2 inhibited recombinant human ICE with an IC50 of 0.006 μmol/L. It also inhibits elastase and cathepsin. CAS No. 189828-32-8. Molecular formula: C12H14O5. Mole weight: 238.24. | |
| EI-2346 | EI-2346 is originally isolated from Streptomyces sp. E-2346. It selectively inhibited ICE, and the IC50 of recombinant human ICE was 3.9 μmol/L. It also inhibits elastase and cathepsin. Synonyms: 3,10-Dihydroxy-8-[5-hydroxy-4-(hydroxymethyl)-1,3-dioxan-2-yl]-3-methyl-1-propyl-3,4-dihydro-1H-benzo[g]isochromene-6,9-dione. Molecular formula: C22H26O9. Mole weight: 434.44. | |
| Elasnin | Elasnin is isolated from certain strains of Streptomyces. Elasnin is a reversible inhibitor of elastase with IC50 values of 1.3 and 30 μg/ml for human granulocyte and pancreatic enzymes, respectively. It inhibits human leukocyte elastase, porcine pancreatic elastase, and chymotrypsin with Ki values of 93, 69 and 224 μM, respectively. Synonyms: 3,5-dibutyl-2-hydroxy-6-(6-oxoundecan-5-yl)-4H-pyran-4-one; 3,?5-Dibutyl-6-(1-butyl-2-oxoheptyl)?-4-hydroxy-2H-pyran-2-one. Grades: ≥98%. CAS No. 68112-21-0. Molecular formula: C24H40O4. Mole weight: 392.57. | |
| Elasnin (3,5-Dibutyl-4-hydroxy-6-(6-oxoundecan-5-yl)-2H-pyran-2-one) | Inhibitor of human leukocyte elastase (IC50=1.3ug/ml), different other elastases and chymotrypsin (IC50=82ug/ml). Group: Biochemicals. Grades: Highly Purified. CAS No. 68112-21-0. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Elastatinal | Elastatinal is a potent and irreversible inhibitor of pancreatic elastase. It is a much stronger inhibitor of pancreatic elastase than the leukocyte-derived enzyme. It can also inhibit elastase-like protease collagenolytic protease from C. maenas digestive glands. Synonyms: (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxyethyl]-L-glutamamide. Grades: ≥ 95 %. CAS No. 51798-45-9. Molecular formula: C21H36N8O7. Mole weight: 512.56. | |
| Elastin-Congo red | elastase substrate. Group: Fluorescence/luminescence spectroscopy. | |
| Elastin-orcein | elastase substrate. Group: Fluorescence/luminescence spectroscopy. | |
| Freselestat | Freselestat is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM) with >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Freselestat can be used as treatment for neutrophil-predominant inflammatory lung diseases. Synonyms: 2-(5-amino-6-oxo-2-phenylpyrimidin-1-yl)-N-[1-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl]acetamide; ONO6818; ONO 6818; ONO-6818. Grades: 95%. CAS No. 208848-19-5. Molecular formula: C23H28N6O4. Mole weight: 452.51. | |
| GW311616 | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616; GW 311616. Grades: >98%. CAS No. 198062-54-3. Molecular formula: C19H31N3O4S. Mole weight: 397.53. | |
| GW311616 hydrochloride | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616 hydrochloride; GW 311616 hydrochloride; GW311616A. Grades: >98%. CAS No. 197890-44-1. Molecular formula: C19H32ClN3O4S. Mole weight: 433.99. | |
| H-Ala-Ala-Ala-OME acetate | H-Ala-Ala-Ala-OME is a substrate for a simultaneous determination of the esterase and the peptidase activities of pancreatic elastase. Synonyms: AAA-OMe. CAS No. 84794-58-1. Molecular formula: C12H23N3O6. Mole weight: 305.33. | |
| H-ALA-ALA-ALA-PNA HCL | H-Ala-Ala-Ala-Pna is a chromogenic substrate for porcine pancreatic elastase and for astacin. Synonyms: H-Ala-Ala-Ala-Pna hydrochloride; (S)-2-amino-N-((S)-1-((S)-1-(4-nitrophenylamino)-1-oxopropan-2-ylamino)-1-oxopropan-2-yl)propanamide hydrochloride; AAA-pNA. CAS No. 50450-80-1. Molecular formula: C15H22ClN5O5. Mole weight: 387.82. | |
| hypodermin C | From the larva of a warble fly, Hypoderma lineatum. Little action on small molecule substrates of trypsin, chymotrypsin, elastase or microbial collagenases. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: Hypoderma collagenase. Enzyme Commission Number: EC 3.4.21.49. CAS No. 122191-36-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4142; hypodermin C; EC 3.4.21.49; 122191-36-0; Hypoderma collagenase. Cat No: EXWM-4142. | |
| LM-030 | LM-030 (BPR277) is a potent kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2) inhibitor with IC 50 s of 6 nM and 55 nM, respectively(Example 4) [1]. LM-030 can be used for the study of Netherton syndrome [2]. Uses: Scientific research. Group: Peptides. Alternative Names: BPR277. CAS No. 1122484-55-2. Pack Sizes: 1 mg. Product ID: HY-P4669. | |
| L-Norlevaline-4-nitoranilide hydrobromide | Substrate for elastase, trypsin and chymotrypsin. Synonyms: L-Nva-pNA HBr. Grades: ≥ 98%. CAS No. 213271-08-0. Molecular formula: C11H15N3O3·HBr. Mole weight: 318.17. | |
| Lonodelestat | Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF) [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: POL6014. CAS No. 906547-89-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3293. | |
| L-Valine amide hydrochloride | L-Valine Amide is a reagent used in the synthesis of alkylpyrazines. Also used in the synthesis of elastase inhibitory activity. Synonyms: L-Val-NH2 HCl; (2S)-2-amino-3-methylbutanamide hydrochloride; H-Val-NH2 HCl; L-Valinamide Hydrochloride. Grades: ≥ 99% (HPLC). CAS No. 3014-80-0. Molecular formula: C5H12N2O·HCl. Mole weight: 152.60. | |
| Meosuc-ala-ala-pro-ala-chloromethylketone | Meosuc-ala-ala-pro-ala-chloromethylketone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: methoxysuccinyl-alanyl-alanyl-prolyl-alaninechloromethylketone;MEOSUC-AAPA-CMK;MEOSUC-ALA-ALA-PRO-ALA-CHLOROMETHYLKETONE;MEOSUC-ALA-ALA-PRO-ALA-CMK;ELASTASE INHIBITOR II;HNE INHIBITOR;MSACK. Product Category: Heterocyclic Organic Compound. CAS No. 111682-13-4. Molecular formula: C20H31ClN4O7. Mole weight: 474.94. Product ID: ACM111682134. Alfa Chemistry ISO 9001:2015 Certified. |  |
| MeoSuc-Ala-Ala-Pro-Val-AMC | MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase. The methoxy succinyl (MeO-Suc) peptide AAPV is hydrolyzed by these elastases but not by cathepsin G. The addition of 7-amino-4-methylcoumarin (AMC) generates a peptide of low fluorescence (excitation: 355-380 nm; emission 440-460 nm) that demonstrates a linear increase in fluorescence intensity in the presence of elastase. Synonyms: MeOSuc-AAPV-AMC;I 1270; Methoxy Succinyl-Ala-Ala-Pro-Val-AMC; N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-valinamide. Grades: ≥95% by HPLC. CAS No. 72252-90-5. Molecular formula: C31H41N5O9. Mole weight: 627.7. | |
| MeOSuc-Ala-Ala-Pro-Val-pNA | MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive chromogenic substrate for human leukocyte and porcine pancreatic elastase [1]. Uses: Scientific research. Group: Peptides. CAS No. 70967-90-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P2685. | |
| Mepenzolate Bromide | Mepenzolate Bromide is a muscarinic antagonist used to treat gastrointestinal disorders, and decreases the severity of elastase-induced airspace enlargement and respiratory dysfunction. Synonyms: Mepenzolate Bromide; Cantil; Gastropidil; Cantilaque; Cantilon; mepenzolate iodide; mepenzolic acid. Grades: >98%. CAS No. 76-90-4. Molecular formula: C21H26BrNO3. Mole weight: 420.34. | |
| Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide - CAS 70967-90-7 | Soluble, specific substrate for human leukocyte elastase. Group: Fluorescence/luminescence spectroscopy. | |
| Native Human α-1-Antitrypsin | Alpha-1 Antitrypsin or α1-antitrypsin (A1AT) is a protease inhibitor belonging to the serpin superfamily. It is generally known as serum trypsin inhibitor. Alpha 1-antitrypsin is also referred to as alpha-1 proteinase inhibitor (A1PI) because it inhibits a wide variety of proteases. It protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has a reference range in blood of 1.5-3.5 gram/liter (in US the reference range is generally expressed as mg/dL or micromoles), but the concentration can rise manyfold upon acute inflammation. In its absence, neutrophil elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (chronic obstructive pulmonary disease) in adults and cirrhosis in adults or children. Group: Enzymes. Synonyms: Alpha-1-Antitrypsin; A1AT; α1-antitrypsin; SERPINA1; A1A; A1AT; AAT; PI; PI1; PRO2275; alpha1AT. CAS No. 9041-92-3. Purity: > 95% (SDS-PAGE). A1AT. Mole weight: 54kDa. Storage: 2-8°C. Form: Lyophilized. Source: Human Plasma. Species: Human. Alpha-1-Antitrypsin; A1AT; α1-antitrypsin; SERPINA1; A1A; A1AT; AAT; PI; PI1; PRO2275; alpha1AT. Cat No: NATE-0010. | |
| Native Human Cathepsin G | Cathepsin G is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, but it is most closely related to other immune serine proteases, such as neutrophil elastase and the granzymes. Cathepsin G may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. It also localizes to Neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases. Transcript variants utilizing alternative polyadenylation signals exist for this gene. Group: Enzymes. Synonyms: CTSG; cathepsin G; CG; CATG; EC 3.4.21.20; chymotrypsin-like proteinase; neutral proteinase. Enzyme Commission Number: EC 3.4.21.20. CAS No. 56645-49-9. Purity: > 96% (SDS-PAGE). CTSG. Activity: > 5 U/mL. Appearance: Clear, colorless solution. Storage: 2-8°C. Form: Liquid. Source: Human Neutrophils. Species: Human. CTSG; cathepsin G; CG; CATG; EC 3.4.21.20; chymotrypsin-like proteinase; neutral proteinase. Cat No: NATE-0173. | |
| Native Papaya latex Chymopapain | Chymopapain is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). It is a medication used to treat herniated lower lumbar discs in the spine. Chymopapain injections are normally given under local, Rather than general, anaesthesia. The dose for a single intervertebral disc is 2 to 4 nanokatals, with a maximum dose per patient of 8 nanokatals. The procedure is referred to as chemonucleolysis. Applications: Chymopapain from papaya latex has been used in a study to assess the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, heligmosomoides. chymopapain from papaya latex has also been used in a study to investiga...enzyme has been used along with pronase, collagenase, elastase, dnase, and catalase for rabbit lung cells digestion at a concentration of 0.05% in calcium-magnesium-free kreb?s serum substitute. it has also been used for the release of neuroblastoma cells from marrow bound to antibody-coated microspheres. Group: Enzymes. Synonyms: chymopapain A; chymopapain B; chymopapain S; EC 3.4.22.6; 9001-09-6; Chymodiactin. Enzyme Commission Number: EC 3.4.22.6. CAS No. 9001-9-6. Chymopapain. Activity: > 2.0 units/mg protein. Storage: -20°C. Form: lyophilized powder. Source: Papaya latex. chymopapain A; chymopapain B; chymopapain S; EC 3.4.22.6; 9001-09-6; Chymodiactin. Cat No: NATE-0133. | |
| N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin | elastase substrate. Group: Fluorescence/luminescence spectroscopy. | |
| N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone | elastase inhibitor. Group: Fluorescence/luminescence spectroscopy. | |
| N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide | elastase substrate. Group: Fluorescence/luminescence spectroscopy. | |
| N-Succinyl-Ala-Ala-Ala-p-nitroanilide | elastase substrate. Group: Fluorescence/luminescence spectroscopy. | |
| N-Succinyl-Ala-Ala-Pro-Leu p-nitroanilide | N-Succinyl-Ala-Ala-Pro-Leu p-nitroanilide is a sensitive substrate for human and especially porcine pancreatic elastases. Synonyms: succinyl-L-Ala-L-Ala-L-Pro-L-Leu-p-nitroanilide; 4-((S)-1-((S)-1-((S)-2-((S)-4-methyl-1-(4-nitrophenylamino)-1-oxopentan-2-ylcarbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-ylamino)-1-oxopropan-2-ylamino)-4-oxobutanoic acid. CAS No. 70968-04-6. Molecular formula: C27H38N6O9. Mole weight: 590.63. | |
| ONO EI-601 | ONO EI-601, a sulfonylamine derivative, is one metabolite of ONO-5046 which is a neutrophil elastase inhibitor that could be effective against acute lung injury. Synonyms: Ono-EI-601; OnoEI601; Ono EI 601; Ono-EI 601; Ono EI-601; AC1MHG4J; N- (2- (p-Hydroxyphenylsulfonylamino) benzoyl) glycine; N- (2- ( ( (4-Hydroxyphenyl) sulfonyl) amino) benzoyl) glycine. Grades: 98%. CAS No. 155023-59-9. Molecular formula: C15H14N2O6S. Mole weight: 350.35. | |
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