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| Product | Description | |
|---|---|---|
| Native Russell's viper venom Factor V Activating Enzyme | Factor V activator for RVV contains fucose, mannose, galactose, glucosamine, and neuraminic acid. Factor V activating enzyme from RVV is an arginine esterase that is sensitive to diisopropyl fluorophosphate (DFP). Applications: Factor v activating enzyme from russells viper venom (rvv) is a single-chain glycoprotein that is involved in the rapid clotting of blood. factor v circulates in the blood as an inactive cofactor and must be activated by proteases such as factor v activating enzyme from rvv 1. this product may be useful in studying the blood coagulation cascade as well as the inherited deficiency called parahemophilia. Group: Enzymes. Synonyms: EC 3.4.21.95; Factor V Activating Enzyme; Snake venom factor V activator; 65522-14-7; Factor V activator. Enzyme Commission Number: EC 3.4.21.95. CAS No. 65522-14-7. Factor V activator. Activity: 20 units/mg protein. Storage: -20°C. Form: lyophilized powder; Stabilized in albumin and sodium chloride. Source: Russell's viper venom. EC 3.4.21.95; Factor V Activating Enzyme; Snake venom factor V activator; 65522-14-7; Factor V activator. Cat No: NATE-0249. |  |
| 10-[3-(2,2-Diimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxypropyl]-7,8-dimethyl-isoalloxazine | 10-[3-(2,2-Diimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxypropyl]-7,8-dimethyl-isoalloxazine is an intermediate uin the synthesis of Riboflavin 4',5'-Diphosphate which is a diphosphate derivative of Riboflavin (R414995); a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor). Group: Biochemicals. Grades: Highly Purified. CAS No. 22854-81-5. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C20H24N4O6. US Biological Life Sciences. |  Worldwide |
| 10- ( ( (4R, 5R, 6S) -6- ( ( (tert-Butyldiphenylsilyl) oxy) methyl) -5-hydroxy-2, 2-dimethyl-1, 3-dioxan-4-yl) methyl) -7, 8-dimethylbenzo [g]pteridine-2, 4 (3H, 10H) -dione | 10- ( ( (4R, 5R, 6S) -6- ( ( (Tert-butyldiphenylsilyl) oxy) methyl) -5-hydroxy-2, 2-dimethyl-1, 3-dioxan-4-yl) methyl) -7, 8-dimethylbenzo [g]pteridine-2, 4 (3H, 10H) -dioneis an intermediate uin the synthesis of Riboflavin 4',5'-Diphosphate which is a diphosphate derivative of Riboflavin (R414995); a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C36H42N4O6Si, Molecular Weight: 654.83. US Biological Life Sciences. | Worldwide |
| 1,4-α-glucan branching enzyme | Converts amylose into amylopectin. The accepted name requires a qualification depending on the product, glycogen or amylopectin, e.g. glycogen branching enzyme, amylopectin branching enzyme. The latter has frequently been termed Q-enzyme. Group: Enzymes. Synonyms: branching enzyme; amylo-(1,4?1,6)-transglycosylase; Q-enzyme; α-glucan-branching glycosyltransferase; amylose isomerase; enzymatic branching factor; branching glycosyltransferase; enzyme Q; glucosan transglycosylase; glycogen branching enzyme; plant branching enzyme; α-1,4-glucan:α-1,4-glucan-6-glycosyltransferase; starch b. Enzyme Commission Number: EC 2.4.1.18. CAS No. 9001-97-2. Glycogen branching enzyme. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2405; 1,4-α-glucan branching enzyme; EC 2.4.1.18; 9001-97-2; branching enzyme; amylo-(1,4?1,6)-transglycosylase; Q-enzyme; α-glucan-branching glycosyltransferase; amylose isomerase; enzymatic branching factor; branching glycosyltransferase; enzyme Q; glucosan transglycosylase; glycogen branching enzyme; plant branching enzyme; α-1,4-glucan:α-1,4-glucan-6-glycosyltransferase; starch branching enzyme; 1,4-α-D-glucan:1,4-α-D-glucan 6-α-D-(1,4-α-D-glucano)-transferase. Cat No: EXWM-2405. | |
| 1,4-DPCA | The pro-angiogenic factor HIF-1α is targeted for destruction in non-hypoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH). It is a promotor of wound healing and tissue regeneration in mice. Synonyms: 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid. Grades: ≥98%. CAS No. 331830-20-7. Molecular formula: C13H8N2O3. Mole weight: 240.2. |  |
| 1-alkylglycerophosphocholine O-acetyltransferase | This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. This enzyme participates in ether lipid metabolism. Group: Enzymes. Synonyms: acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase; acetyl-CoA:lyso-PAF acetyltransferase; 1-alkyl-2-lysolecithin acetyltransferase; acyl-CoA:1-alkyl-sn-glycero-3-phosphoc. Enzyme Commission Number: EC 2.3.1.67. CAS No. 76773-96-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2247; 1-alkylglycerophosphocholine O-acetyltransferase; EC 2.3.1.67; 76773-96-1; acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase; acetyl-CoA:lyso-PAF acetyltransferase; 1-alkyl-2-lysolecithin acetyltransferase; acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase; blood platelet-activating factor acetyltransferase; lyso-GPC:acetyl CoA acetyltransferase; lyso-platelet activating factor:acetyl-CoA acetyltransferase; lysoPAF:acetyl CoA acetyltransferase; PAF acetyltransferase; platelet-activating factor acylhydrolase; platelet-activating factor-synthesizing enzyme; 1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase; lyso-platelet-activating factor:acetyl-CoA acetyltransferase. Cat No: EXWM-2247. | |
| 1-Deoxy-1-[ (3-hydroxymethyl-4-methyl-6- (2-phenyldiazenyl) phenyl) amino]-D-ribitol | 1-Deoxy-1-[ (3-hydroxymethyl-4-methyl-6- (2-phenyldiazenyl) phenyl) amino]-D-ribitol is an intermediate in the synthesis of 8-Hydroxymethyl Riboflavin which is an impurity of Riboflavin (R414995), a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C19H25N3O5. US Biological Life Sciences. | Worldwide |
| 1-Deoxy-1-[(3-hydroxymethyl-4-methylphenyl)amino]-D-ribitol | 1-Deoxy-1-[(3-hydroxymethyl-4-methylphenyl)amino]-D-ribitol is an intermediate in the synthesis of 8-Hydroxymethyl Riboflavin which is an impurity of Riboflavin (R414995), a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C13H21NO5. US Biological Life Sciences. | Worldwide |
| 2-(3-amino-3-carboxypropyl)histidine synthase | A [4Fe-4S] enzyme that modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical. The enzyme is present in archae and eukaryotes but not in eubacteria. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii. Part of diphthamide biosynthesis. Group: Enzymes. Synonyms: Dph2. Enzyme Commission Number: EC 2.5.1.108. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2724; 2-(3-amino-3-carboxypropyl)histidine synthase; EC 2.5.1.108; Dph2. Cat No: EXWM-2724. | |
| 2-((5-Chloropyridin-2-yl)amino)-2-oxoacetic Acid | 2-((5-Chloropyridin-2-yl)amino)-2-oxoacetic Acid is a reactant or reagent used in the synthesis of the blood coagulating enzyme factor Xa (FXa) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 552850-73-4. Pack Sizes: 1g, 5g. Molecular Formula: C7H5ClN2O3, Molecular Weight: 200.58. US Biological Life Sciences. | Worldwide |
| 2-heptyl-4(1H)-quinolone synthase | The enzyme from the Gram-negative bacterium Pseudomonas aeruginosa is involved in the biosynthesis of 2-heptyl-4-hydroxyquinoline and 2,4-dihydroxyquinoline. 2-Heptyl-4-hydroxyquinoline is a signal molecule, that is involved in regulation of virulence factor production and biofilm formation. The enzyme shows a broad specificity and is involved in the synthesis of a wide array of additional 2-alkyl-4(1H)-quinolones synthesized by the organism. Group: Enzymes. Enzyme Commission Number: EC 2.3.1.230. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2178; 2-heptyl-4(1H)-quinolone synthase; EC 2.3.1.230. Cat No: EXWM-2178. | |
| 2-oxoglutarate carboxylase | A biotin-containing enzyme that requires Mg2+ for activity. It was originally thought that this enzyme was a promoting factor for the carboxylation of 2-oxoglutarate by EC 1.1.1.41, isocitrate dehydrogenase (NAD+), but this has since been disproved. The product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 1.1.1.41. Group: Enzymes. Synonyms: oxalosuccinate synthetase; carboxylating factor for ICDH (incorrect); CFI; OGC. Enzyme Commission Number: EC 6.4.1.7. CAS No. 60382-75-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5818; 2-oxoglutarate carboxylase; EC 6.4.1.7; 60382-75-4; oxalosuccinate synthetase; carboxylating factor for ICDH (incorrect); CFI; OGC. Cat No: EXWM-5818. | |
| 4'-Cyanouridine | Utilizing the crucial factors of "perplexity" and "burstiness," 4'-Cyanouridine, a modified nucleoside, displays promise as an antitumor agent. Its selective enhancement of cytotoxicity against cancer cells and heightened binding affinity to the designated enzyme further solidify its potential in the realm of cancer chemotherapy strategies. Synonyms: uridine, 4'-C-cyano-; (2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrofuran-2-carbonitrile. Grades: ≥95%. CAS No. 232589-05-8. Molecular formula: C10H11N3O6. Mole weight: 269.21. | |
| 4-IPP | 4-IPP is a potent and cell-permeable macrophage migration inhibitory factor (MIF) antagonist. It covalently modifies MIF N-terminal proline. It inhibits MIF-associated liver enzyme activity in vivo and acts as a suicide substrate to inactivate MIF biological and catalytic functions. It also inhibits anchorage and migration independence of human lung adenocarcinoma cell lines in vitro. Synonyms: 4-IPP; 4 IPP; 4IPP; 4-Iodo-6-phenylpyrimidine. Grades: ≥99% by HPLC. CAS No. 41270-96-6. Molecular formula: C10H7IN2. Mole weight: 282.08. | |
| 5-(Acetylamino)-5-deoxy-3-S-phenyl-3-thio-D-erythro-a-L-gluco-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate | 5-(Acetylamino)-5-deoxy-3-S-phenyl-3-thio-D-erythro-a-L-gluco-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate is a compound emerging as an imposing restraint factor for select enzymes implicated in the pathogenesis of specific maladies. It has remarkable research and development in viral afflictions, influenza contagions is and various cancerous manifestations. Synonyms: methyl (2S,3S,4S,5S)-5-acetamido-2,4-diacetyloxy-3-phenylsulfanyl-6-[(1S,2R)-1,2,3-triacetyloxypropyl]oxane-2-carboxylate; 156726-98-6; 5-(Acetylamino)-5-deoxy-3-S-phenyl-3-thio-D-erythro-alpha-L-gluco-2-nonulopyranosonic Acid Methyl Ester; AKOS030254710; CID 46783737. CAS No. 156726-98-6. Molecular formula: C28H35NO14S. Mole weight: 641.64. | |
| 5-fluoro 203 | The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. 5-fluoro 203 is a cytotoxic compound that at 1 μM activates AhR signaling. Synonyms: NSC 703786; 4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylaniline. Grades: ≥98%. CAS No. 260443-89-8. Molecular formula: C14H11FN2S. Mole weight: 258.3. | |
| 5'-O-Acetyl-2',3'-dideoxyinosine | 5'-O-Acetyl-2',3'-dideoxyinosine is an extensively utilized potent antiviral compound within the biomedical field, exhibiting impressive efficacy in research of viral infections induced by the human immunodeficiency virus (HIV). By impeding the reverse transcriptase enzyme, a pivotal factor for viral replication, this compound effectively impedes viral multiplication. Synonyms: 5'-O-Acetyldidanosine; 5'-O-Acetyl-2',3'-dideoxy-D-inosine. CAS No. 130676-58-3. Molecular formula: C12H14N4O4. Mole weight: 278.26. | |
| 5'-Trt-N2-ibu-rG | 5'-Trt-N2-ibu-rG, a nucleoside analog, exhibits strong potential as an effective anticancer agent, as it has been demonstrated to impede the growth and spread of certain cancer cell types, including leukemia and breast cancer. The mechanism behind its tumor suppression lies in its specific targeting of the RNA polymerase II enzyme, a key factor in the transcription of cancer-promoting genes, thus providing a promising avenue for chemotherapy. Synonyms: 5'-O-Trt-N2-ibu-rG. Grades: ≥98% by HPLC. Molecular formula: C33H32N5O6. Mole weight: 595.65. | |
| ADAM 17 endopeptidase | In peptidase family M12. In vivo, the cleavage of tumour necrosis factor α precursor releases the soluble, 17-kDa TNFα, which induces inflammation. Group: Enzymes. Synonyms: tumor necrosis factor α-converting enzyme; TACE. Enzyme Commission Number: EC 3.4.24.86. CAS No. 151769-16-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4370; ADAM 17 endopeptidase; EC 3.4.24.86; 151769-16-3; tumor necrosis factor α-converting enzyme; TACE. Cat No: EXWM-4370. | |
| ADAMTS13 endopeptidase | In peptidase family M12. Group: Enzymes. Synonyms: ADAMTS VWF cleaving metalloprotease; ADAMTS-13; ADAMTS13;vWF-cleaving protease; VWF-CP; vWF-degrading protease; Upshaw factor; von Willebrand factor cleaving protease; ADAMTS13 peptidase. Enzyme Commission Number: EC 3.4.24.87. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4371; ADAMTS13 endopeptidase; EC 3.4.24.87; ADAMTS VWF cleaving metalloprotease; ADAMTS-13; ADAMTS13;vWF-cleaving protease; VWF-CP; vWF-degrading protease; Upshaw factor; von Willebrand factor cleaving protease; ADAMTS13 peptidase. Cat No: EXWM-4371. | |
| adenosyl-fluoride synthase | The fluorinase enzyme (EC 2.5.1.63, also known as adenosyl-fluoride synthase) catalyzes the reaction between fluoride ion and the co-factor S-adenosyl-L-methionine to generate L-methionine and 5'-fluoro-5'-deoxyadenosine, the first committed product of the fluorometabolite biosynthesis pathway. Group: Enzymes. Synonyms: fluorinase. Enzyme Commission Number: EC 2.5.1.63. CAS No. 438583-16-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2801; adenosyl-fluoride synthase; EC 2.5.1.63; 438583-16-5; fluorinase. Cat No: EXWM-2801. | |
| AG-213 | AG-213 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 2.4 μM in the human epidermoid carcinoma cell line A431. Uses: Enzyme inhibitors. Synonyms: Tyrphostin AG-213; Tyrphostin 47; (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide. Grades: ≥97%. CAS No. 122520-86-9. Molecular formula: C10H8N2O2S. Mole weight: 220.2. | |
| a-L-Fucose-1-phosphate bis(cyclohexylammonium) salt | A paramount constituent in the field of biomedicine, a-L-Fucose-1-phosphate bis(cyclohexylammonium) salt serves as a pivotal factor in the production and analysis of enzymes related to carbohydrate metabolism. Its crucial role further extends to research on liver glycogen storage diseases, as well as in the treatment of select forms of malignancy. Indeed, this reagent proves itself to be a fundamental cornerstone in contemporary biomedical research. Synonyms: α-L-Fucose-1-phosphate (cyclohexylammonium salt); 6-Deoxy-α-L-Galactopyranose 1-(Dihydrogen Phosphate) Cyclohexanamine (1:2); α-L-Fucopyranose 1-(Dihydrogen Phosphate) Di(cyclohexylammonium) Salt; α-L-Fucopyranosyl 1-Phosphate Di(cyclohexylammonium) Salt; α-L-Fucopyranosyl Phosphate Di(cyclohexylammonium) Salt. Grades: ≥98%. CAS No. 24333-03-7. Molecular formula: C6H13O8P.2C6H13N. Mole weight: 442.48. | |
| alkylacetylglycerophosphatase | Involved in the biosynthesis of thrombocyte activating factor in animal tissues. Group: Enzymes. Synonyms: 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase; alkylacetylglycerophosphate phosphatase. Enzyme Commission Number: EC 3.1.3.59. CAS No. 102925-45-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3664; alkylacetylglycerophosphatase; EC 3.1.3.59; 102925-45-1; 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase; alkylacetylglycerophosphate phosphatase. Cat No: EXWM-3664. | |
| alkylglycerophosphate 2-O-acetyltransferase | Involved in the biosynthesis of thrombocyte activating factor in animal tissues. Group: Enzymes. Synonyms: alkyllyso-GP:acetyl-CoA acetyltransferase. Enzyme Commission Number: EC 2.3.1.105. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2043; alkylglycerophosphate 2-O-acetyltransferase; EC 2.3.1.105; alkyllyso-GP:acetyl-CoA acetyltransferase. Cat No: EXWM-2043. | |
| α-factor-transporting ATPase | ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A yeast enzyme that exports the α-factor sex pheromone. Group: Enzymes. Enzyme Commission Number: EC 7.4.2.7 (Formerly EC 3.6.3.48). Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4686; α-factor-transporting ATPase; EC 3.6.3.48. Cat No: EXWM-4686. | |
| α-Lipoic Acid | α-Lipoic Acid is a metabolic antioxidant that regulates NFκB signal transduction and can protect against oxidative injury. The exogenous compound is reduced intracellularly by enzymes. Its reduced form is involved in radical scavenging, recycling of other antioxidants, accelerating GSH synthesis, and regulating transcription factor activity, specifically NFkappaB. It also acts as a conenzyme that is required for the activity of pyruvate dehydrogenase and glycine decarboxylase, among other enzyme complexes. Studies show that it can prevent a decrease in the renal antioxidant defense system and prevent the increase of lipid peroxidation, platinum content and plasma creatinine concentrations. In other studies, lipoic acid decreased the phagocytosis of myelin by macrophages, acting as a non-specific scavenger of reactive oxygen species (ROS). Applications: A metabolic antioxidant that regulates nf-κb signal transduction. Group: Coenzymes. Synonyms: DL-Thioctic Acid; DL-6,8-Dithiooctanoic acid; 1,2-Dithiolane-3-valeric acid. CAS No. 1077-28-7. Purity: ≥95%. Mole weight: 206.32. Form: Solid. DL-Thioctic Acid; DL-6,8-Dithiooctanoic acid; 1,2-Dithiolane-3-valeric acid; α-Lipoic Acid; 1077-28-7. Cat No: COEC-041. | |
| alternative-complement-pathway C3/C5 convertase | A bimolecular complex of complement fragment Bb with either C3b or cobra venom factor; Bb contains the active site. Bb is formed by cleavage of proenzyme factor B by factor D. Cleavage of complement component C5 requires additional C3b which binds C5 and renders it susceptible to cleavage by C3b,Bb complex. C3b,Bb is stabilized in plasma by factor P. Complement factor B is in peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: complement component C3/C5 convertase (alternative); proenzyme factor B; properdin factor B; C3 proactivator; glycine-rich β-glycoprotein; heat-labile factor; C3 convertase; C3. Enzyme Commission Number: EC 3.4.21.47. CAS No. 80295-67-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4140; alternative-complement-pathway C3/C5 convertase; EC 3.4.21.47; 80295-67-6; complement component C3/C5 convertase (alternative); proenzyme factor B; properdin factor B; C3 proactivator; glycine-rich β-glycoprotein; heat-labile factor; C3 convertase; C3b,Bb,CVF,Bb,C5 convertase; (C3b)n,Bb; complement C 3(C 5) convertase (amplification); alternative complement pathway C3(C5) convertase; C5 convertase; CVF,Bb; (CVF)-dependent glycine-rich-β-glucoprotein; cobra venom factor-dependent C3 convertase. Cat No: EXWM-4140. | |
| AMPK Signaling Agonist, F17 (4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide) | A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~0.1uM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-a1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25uM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C. Group: Biochemicals. Grades: Highly Purified. CAS No. 280112-24-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| anthrax lethal factor endopeptidase | From the bacterium Bacilus anthracis that causes anthrax. One of three proteins that are collectively termed anthrax toxin. Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. In peptidase family M34. Group: Enzymes. Synonyms: lethal toxin. Enzyme Commission Number: EC 3.4.24.83. CAS No. 477950-41-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4367; anthrax lethal factor endopeptidase; EC 3.4.24.83; 477950-41-7; lethal toxin. Cat No: EXWM-4367. | |
| Arginine Deiminase (Crude Enzyme) | This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. This enzyme participates in arginine and proline metabolism. This enzyme is widely expressed in bacteria, including streptococcus and actinomyces. The bacterial arginine deiminase expression could be regulated by various environmental factors. This product with the indicated enzyme activity was briefly purified from engineered E. coli. Applications: Drug development; medicine; pharmacology. Group: Enzymes. Synonyms: arginine dihydrolase; citrulline iminase; L-arginine deiminase. Enzyme Commission Number: EC 3.5.3.6. CAS No. 9027-98-9. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. arginine dihydrolase; citrulline iminase; L-arginine deiminase. Pack: 100ml. Cat No: NATE-1841. | |
| BCX 1470 | In vitro BCX 1470 inhibits the esterolytic and hemolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM) which is the complement enzymes. BCX 1470 may used for the treatment of complement activation during cardiopulmonary bypass surgery. Synonyms: (2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate; 2-amidino-6-(2-thiophene carboxy)benzothiophene methanesulfonate; BCX 1470; BCX1470; BCX-1470. Grades: 95%. CAS No. 217099-43-9. Molecular formula: C14H10N2O2S2. Mole weight: 302.37. | |
| BCX 1470 methanesulfonate | BCX 1470 methanesulfonate is methanesulfonate salt form of BCX 1470. In vitro BCX 1470 inhibits the esterolytic and hemolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM) which is the complement enzymes. BCX 1470 may used for the treatment of c. Synonyms: BCX 1470 methanesulfonate; BCX-1470 methanesulfonate; BCX1470 methanesulfonate; (2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate;methanesulfonic acidBCX 1470 (methanesulfonate)217099-44-0BCX 1470 (methanesulfonate) CHEMBL2203422C14H10N2O2S2. CH4O3S3166AH2- (Aminoiminomethyl) benzo[b]thiophen-6-yl ester 2-thiophenecarb. Grades: 95%. CAS No. 217099-44-0. Molecular formula: C14H10N2O2S2.CH4O3S. Mole weight: 398.47. | |
| Berberine Hydrochloride | An isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells. Also inhibits Activator Protein 1 (AP-1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs. Group: Biochemicals. Alternative Names: 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium Chloride; Berberine Chloride; 7, 8, 13, 13a-Tetradehydro-9, 10-dimethoxy-2, 3- (methylenedioxy) berbinium Chloride; Berberine Hydrochloride; NSC 646666. Grades: Highly Purified. CAS No. 633-65-8. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
| Biotin | Biotin, also known as vitamin B7, is a water-soluble enzyme cofactor generated by intestinal bacteria or obtained from diet. Biotin is a growth factor present in minute amounts in every living cell. It is involved in metabolism of fats and carbohydrates, cell growth, as well as protein synthesis. Vitamin supplement in health care products. Uses: Ingredient of health care products. Synonyms: D-biotin; Vitamin H; Coenzyme R; Vitamin B7; BIOTIN; 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, [3aS-(3aα,4β,6aα)]-; FACTOR S; BIOS H; Ritatin; biosii; BIOTINUM; D-Biotin; Bios-IIb; Meribin; cis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; 1swk; Meribin; Factor S (vitamin); Injacom H; Lutavit H2; D-Biotin. Grades: 98%. CAS No. 58-85-5. Molecular formula: C10H16N2O3S. Mole weight: 244.31. | |
| Biotinylated Transglutaminase from Human, Proenzyme (Zymogen) | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. Applications: The transglutaminase 3 catalyzes acyl transfer reactions from glutamin residues in proteins or peptides to primary amines, e. g. the formation of ε-(γ-glutamyl) lysine bonds between proteins by transferring the acyl group of a peptide-bound glutamine residue to the primary amino group of a peptide-bound lysine residue. biotinylated transglutaminase 3 may also be used for immunoprecipitation. Group: Enzymes. Synonyms: transglutaminase; EC 2.3.2.13; 80146-85-6; transgl...]. Appearance: Liquid. Storage: Store at -20 °C in working aliquots. Repeated freezing and thawing is not recommended. Form: The transglutaminase is formulated in 10 mM Sodium Phosphate pH 8.0, 15 mM NaCl. Sample contains 50% glycerol. Transglutaminase is a Ca2+-dependent enzyme. Source: E. coli. Species: Human. transglutaminase; EC 2.3.2.13; 80146-85-6; transglutaminase; Factor XIIIa; fibrinoligase; fibrin stabilizing factor; glutaminylpeptide γ-glutamyltransferase; polyamine transglutaminase; tissue transglutaminase; R-glutaminyl-peptide:amine γ-glutamyl transferase; protein-glutamine γ-glutamyltransferase; TG1. Pack: 100 ug. Cat No: NATE-173 | |
| Biotinylated Transglutaminase from Human, Recombinant | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. Applications: Recombinant human transglutaminase is a homodimer (a2) composed of two chains held together by non covalent bonds. after activation of the zymogen by thrombin and ca2+ to its active form (a*2, factor xiiia), factor xiiia catalyzes the formation of covalent bridges (ε-(γ-glutamyl) lysine bonds) between fibrin units to increase the elasticity of the clot network. the resulting cross-linked fibrin is insoluble and resistant to lysis. Group: Enzymes. Synonyms: transglutamina... Lorand et al., Anal. Biochem. 44 (221-231). Appearance: Liquid. Storage: Store working aliquots at ≤ - 20°C. Avoid repeated freezing and thawing. Form: The transglutaminase is formulated in 10 mM Sodium Phosphate pH 8.0, 15 mM NaCl. Sample contains 50% glycerol. hFXIII is a Ca2+-dependent enzyme. Source: Insect cells. Species: Human. transglutaminase; EC 2.3.2.13; 80146-85-6; transglutaminase; Factor XIIIa; fibrinoligase; fibrin stabilizing factor; glutaminylpeptide γ-glutamyltransferase; polyamine transglutaminase; tissue transglutaminase; R-glutaminyl-peptide:amine γ-glutamyl transferase; protein-glutamine γ-glutamyltransferase; TG1. Pack: 50 | |
| BMS561392 | BMS561392 is a tumor necrosis factor-alpha (TNF alpha) converting enzyme inhibitor. It has the potential treatment of diseases characterized by overproduction of TNF alpha, such as rheumatoid arthritis (RA). It was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated. Uses: Bms561392 has the potential treatment of diseases characterized by overproduction of tnf alpha, such as rheumatoid arthritis (ra). Synonyms: BMS-561392; BMS561392; BMS 561392; DPC-333; DPC 333; DPC333. (αR,?3R)?-3-Amino-N-hydroxy-α-(2-methylpropyl)?-3-[4-[(2-methyl-4-quinolinyl)?methoxy]?phenyl]?-2-oxo-1-pyrrolidineacetamide?;BMS-561392;DPC-333;(2R)-2-[(3R)-3-amino-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]-N-hyd. Grades: 98%. CAS No. 611227-74-8. Molecular formula: C27H32N4O4. Mole weight: 476.57. | |
| Boc-Glu(OBzl)-Gly-Arg-AMC HCl | Substrate for coagulation factors IXa and XIIa as well as for trypsin and soybean trypsin-like enzyme. Synonyms: benzyl (4S)-5-[[2-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoate hydrochloride. Grades: ≥ 96% (HPLC). CAS No. 133448-22-3. Molecular formula: C35H45N7O9·HCl. Mole weight: 744.24. | |
| Boc-Ile-Glu-Gly-Arg-AMC | Boc-IEGR-AMC is a specific, highly fluorogenic substrate for clotting enzyme factor Xa (coagulation factor Xa). Synonyms: Boc-ile-glu-gly-arg-7-amido-4-methylcoumarin; 7-(Nalpha-tert-butyloxycarbonyl-L-isoleucyl-L-glutamylglycyl-L-arginyl)amino-4-methylcoumarin. Grades: >97%. CAS No. 65147-06-0. Molecular formula: C34H50N8O10. Mole weight: 730.81. | |
| Brivudine | Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy. Overall, the gene expression changes associated with BVDU treatment result in the decrease or prevention of chemoresistance. In addition, this agent has been shown to enhance the cytolytic activity of NK-92 natural killer cells towards a pancreatic cancer cell line in vitro. Synonyms: (E)-5-(2-Bromovinyl)-2'-deoxyuridine; (E)-5-(2-Bromovinyl)deoxyuridine; (E)-5-O-(2-bromoethenyl)-2'-deoxyuridine; 5-[(1E)-2-Bromoethenyl]-2'-deoxyuridine; 5-[(E)-2-Bromoethenyl]-2'-deoxyuridine; BVDU; Brivudin; Bromovinyldeoxyuridine; Helpin. Grades: ≥98% by HPLC. CAS No. 69304-47-8. Molecular formula: C11H13BrN2O5. Mole weight: 333.14. | |
| Cardamonin | Cardamonin can be found from cardamom, and can target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR , NF-κB , Akt , STAT3 , Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Cardamomin; Alpinetin chalcone. CAS No. 18956-16-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-N0279. |  |
| Cardamonin | Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: cardamonin. Product Category: Inhibitors. Appearance: Solid. CAS No. 18956-16-6. Molecular formula: C16H14O4. Mole weight: 270.28. Purity: 0.96. IUPACName: (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one. Canonical SMILES: COC1=CC(=CC(=C1C(=O)C=CC2=CC=CC=C2)O)O. Density: 1.282g/cm³. Product ID: ACM18956166. Alfa Chemistry ISO 9001:2015 Certified. Categories: Cardamomin. |  |
| Casein Kinase Iδ rat, Recombinant | The Casein kinase 1 family of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling, circadian rhythms, nucleo-cytoplasmic shuttling of transcription factors, DNA repair, and DNA transcription. C-terminal truncated, n-terminal his-tag/s-tag, > 90% (sds-page), recombinant, expressed in e. coli, solution. Group: Enzymes. Synonyms: Casein Kinase Iδ; Casein Kinase I; CK-Iδ; CK-I; Non-specific serine/threonine protein kinase; Protein phosphokinase; Protein serine kinase; Protein serine-threonine kinase; Protein-serine kinase; Serine kinase; Serine protein kinase; Serine (threonine) protein kinase; Serine-specific protein kinase; Serine/t. Purity: > 90% (SDS-PAGE). CK-I&delta. Mole weight: mol wt 41.8 kDa. Activity: 1,000-3,000 units/mg protein. Stability: -20°C. Form: solution. Source: E. coli. Species: Rat. Casein Kinase Iδ; Casein Kinase I; CK-Iδ; CK-I; Non-specific serine/threonine protein kinase; Protein phosphokinase; Protein serine kinase; Protein serine-threonine kinase; Protein-serine kinase; Serine kinase; Serine protein kinase; Serine (threonine) protein kinase; Serine-specific protein kinase; Serine/threonine protein kinase; Threonine-specific protein kinase. Cat No: NATE-0140. | |
| caspase-1 | From mammalian monocytes. This enzyme is part of the family of inflammatory caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Cleaves pro-interleukin-1β (pro-IL-1β) to form mature IL-1β, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-γ-inducing factor. Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. Caspase-11 plays a critical role in the activation of caspase-1 in mi...proteinase; ICE. Enzyme Commission Number: EC 3.4.22.36. CAS No. 122191-40-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4211; caspase-1; EC 3.4.22.36; 122191-40-6; interleukin 1β-converting enzyme; protease VII; protease A; interleukin 1β precursor proteinase; interleukin 1 converting enzyme; interleukin 1β-converting endopeptidase; interleukin-1β convertase; interleukin-1β converting enzyme; interleukin-1β precursor proteinase; prointerleukin 1β protease; precursor interleukin-1β converting enzyme; pro-interleukin 1β proteinase; ICE. Cat No: EXWM-4211. | |
| caspase-9 | Caspase-9 is an initiator caspase, as are caspase -2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-10 (EC 3.4.22.63). Caspase-9 contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. An alternatively spliced version of caspase-9 also exists, caspase-9S, that inhibits apoptosis, similar to the situation found with caspase-2. Phosphorylation of caspase-9 from some species by Akt, a serine-threonine protein kinase, inhibits caspase activity in vitro and caspase activation in vivo. The activity of caspase-9 is increased dramatically upon association with the apoptosome but the enzyme can be activated without proteolytic cleavage. Procaspase-3 is the enzyme's physiological substrate. Belongs in peptidase family C14. Group: Enzymes. Synonyms: CASP-9; ICE-like apoptotic protease 6; ICE-LAP6; apoptotic protease Mch-6; apoptotic protease-activating factor 3; APAF-3. Enzyme Commission Number: EC 3.4.22.62. CAS No. 180189-96-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4238; caspase-9; EC 3.4.22.62; 180189-96-2; CASP-9; ICE-like apoptotic protease 6; ICE-LAP6; apoptotic protease Mch-6; apoptotic protease-activating factor 3; APAF-3. Cat No: EXWM-4238. | |
| Chemically modified Pseudomonas species Lipoprotein Lipase | Enzyme that hydrolyzes triglycerides into three free fatty acids and glycerol. Take advantage of the enhanced liquid stability of this enzyme. Rely on the proven diagnostic quality of this product. Applications: Use lipoprotein lipase in diagnostic tests for the determination of triglycerides together with glycerol kinase and glycerol-3-phosphate dehydrogenase. Group: Enzymes. Synonyms: Lipoprotein lipase; LPL; Clearing factor lipase; Diacylglycerol lipase; Diglyceride lipase. LPL. Mole weight: 47 kD. Activity: >10 U/mg lyophilizate. Stability: At +2 to +8°C within specification range for 12 months. Store dry. Appearance: Brownish lyophilizate. Source: Pseudomonas species. Lipoprotein lipase; LPL; EC 3.1.1.34; Clearing factor lipase; Diacylglycerol lipase; Diglyceride lipase. Cat No: DIA-282. | |
| Chicking biddy feed enzymes | It is developed according to the digestive physiology of chicks and typical diets. The results of experiments showed that the products could not only effectively supplement the digestive enzyme of chicks, but also inhibited the proliferation of pathogen, improved the health condition of chick, and then enhanced feed utilization ratio. Thus the growth rate was increased uniformly. Ingredients: Protease, amylase, lipase, xylanase, β-mannanase, α-galactosidase. Applications: 1. make up inadequate secretion of endogenous enzyme of chicks to improve animal feed intake and feed efficiency; 2. through inhibiting the proliferation of harmful microorganisms, to improve chick growth rate and colony homogeneity; 3. increase their survival rate by enhancing disease resistance of chicks; 4. by means of breaking down anti-nutritional factors in feed, to improve digestion and absorption of the dietary energy and protein; 5. it can reduce excretion of nitrogen and phosphorus, to reduce environmental pollution. Group: Enzymes. Synonyms: Chicking biddy feed enzymes; digestive enzymes; enhanced feed utilization ratio; impro. Chicking biddy feed enzymes. Appearance: pellet. Chicking biddy feed enzymes; digestive enzymes; enhanced feed utilization ratio; improve chick growth rate; FEED-2329. Pack: 25kg/barrel or subject to client requirement. Cat No: FEED-2329. | |
| coagulation factor IXa | A chymotrypsin homologue, and one of the γ-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: activated Christmas factor; blood-coagulation factor IXa; activated blood-coagulation factor IX; autoprothrombin II; blood platelet cofactor II; activated blood coagulation factor XI. Enzyme Commission Number: EC 3.4.21.22. CAS No. 37316-87-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4122; coagulation factor IXa; EC 3.4.21.22; 37316-87-3; activated Christmas factor; blood-coagulation factor IXa; activated blood-coagulation factor IX; autoprothrombin II; blood platelet cofactor II; activated blood coagulation factor XI. Cat No: EXWM-4122. | |
| coagulation factor VIIa | Formed from the precursor factor VII. The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: blood-coagulation factor VIIa; activated blood coagulation factor VII. Enzyme Commission Number: EC 3.4.21.21. CAS No. 65312-43-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4121; coagulation factor VIIa; EC 3.4.21.21; 65312-43-8; blood-coagulation factor VIIa; activated blood coagulation factor VII. Cat No: EXWM-4121. | |
| coagulation factor Xa | A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va. Group: Enzymes. Synonyms: thrombokinase; prothrombase; prothrombinase; activated blood-coagulation factor X; autoprothrombin C; thromboplastin; plasma thromboplastin; factor Xa; activated Stuart-Prower factor; activated factor X. Enzyme Commission Number: EC 3.4.21.6. CAS No. 9002-5-5. Factor Xa. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4150; coagulation factor Xa; EC 3.4.21.6; 9002-05-5; thrombokinase; prothrombase; prothrombinase; activated blood-coagulation factor X; autoprothrombin C; thromboplastin; plasma thromboplastin; factor Xa; activated Stuart-Prower factor; activated factor X. Cat No: EXWM-4150. | |
| coagulation factor XIa | In peptidase family S1 (trypsin family), and one of the γ-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor XI is activated by factor XIIa. Group: Enzymes. Synonyms: blood-coagulation factor XIa; activated blood-coagulation factor XI; activated plasma thromboplastin antecedent. Enzyme Commission Number: EC 3.4.21.27. CAS No. 37203-61-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4125; coagulation factor XIa; EC 3.4.21.27; 37203-61-5; blood-coagulation factor XIa; activated blood-coagulation factor XI; activated plasma thromboplastin antecedent. Cat No: EXWM-4125. | |
| coagulation factor XIIa | Also activates plasminogen and plasma prokallikrein. Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: Hageman factor (activated); blood-coagulation factor XIIf; activated β blood-coagulation factor XII; prealbumin activator; Hageman factor β-fragment; Hageman factor fragment HFf; blood-coagulation factor XIIaβ; prekallikrein activator; kallikreinogen activator. Enzyme Commission Number: EC 3.4.21.38. CAS No. 75216-42-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4132; coagulation factor XIIa; EC 3.4.21.38; 75216-42-1; Hageman factor (activated); blood-coagulation factor XIIf; activated β blood-coagulation factor XII; prealbumin activator; Hageman factor β-fragment; Hageman factor fragment HFf; blood-coagulation factor XIIaβ; prekallikrein activator; kallikreinogen activator. Cat No: EXWM-4132. | |
| cobalt-factor II C20-methyltransferase | Involved in the anaerobic biosynthesis of vitamin B12. Group: Enzymes. Synonyms: CbiL. Enzyme Commission Number: EC 2.1.1.151. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1747; cobalt-factor II C20-methyltransferase; EC 2.1.1.151; CbiL. Cat No: EXWM-1747. | |
| cobalt-factor III methyltransferase | Isolated from Bacillus megaterium. The enzyme catalyses both methylation at C-17 and ring contraction. Contains a [4Fe-4S] cluster. It can also convert cobalt-precorrin-3 to cobalt-precorrin-4. The reductant may be thioredoxin. Group: Enzymes. Synonyms: CbiH60 (gene name). Enzyme Commission Number: EC 2.1.1.272. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1878; cobalt-factor III methyltransferase; EC 2.1.1.272; CbiH60 (gene name). Cat No: EXWM-1878. | |
| complement factor D | A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C1s. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: C3 proactivator convertase; properdin factor D esterase; factor D; factor D (complement). Enzyme Commission Number: EC 3.4.21.46. CAS No. 37213-56-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4139; complement factor D; EC 3.4.21.46; 37213-56-2; C3 proactivator convertase; properdin factor D esterase; factor D; factor D (complement). Cat No: EXWM-4139. | |
| complement factor I | Cleavage of complement subcomponent C3b requires its binding to cofactor factor H or complement receptor CR1; cleavage of iC3b requires complement receptor CR1; cleavage of C4b requires C4b-binding protein. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: complement component C3b inactivator; C3b inactivator; C3b/C4b inactivator; C3bINA; complement C3b/C4b inactivator; complement C4b inactivator; conglutinogen-activating factor C; complement C3b inactivator; factor I; complement C4bi. Enzyme Commission Number: EC 3.4.21.45. CAS No. 80295-66-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4138; complement factor I; EC 3.4.21.45; 80295-66-5; complement component C3b inactivator; C3b inactivator; C3b/C4b inactivator; C3bINA; complement C3b/C4b inactivator; complement C4b inactivator; conglutinogen-activating factor C; complement C3b inactivator; factor I; complement C4bi. Cat No: EXWM-4138. | |
| CUDC-101 | CUDC-101 is a multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC. Synonyms: CUDC101; CUDC 101; CUDC-101. CAS No. 1012054-59-9. Molecular formula: C24H26N4O4. Mole weight: 434.496. | |
| Cyclosporin | It is produced by the strain of Polypocladiurn inflatum. It has a strong immunosuppressive action, but also has anti-inflammatory and weak antifungal effects. The mechanism of immunosuppression is the combination of cyclosporin A and cyclosporin-binding protein in T cells, which inhibits the activity of Calcineurin, and then impedes the transposition of intracellular transcription factors into the nucleus, and inhibits the interleukin-2 transcription, resulting in immunosuppression. It is mainly used for kidney transplantation, bone marrow and heart transplantation, and is one of the most important immunosuppressive agents in clinical application. Uses: Enzyme inhibitors. Synonyms: Restasis; Cyclosporine; Gengraf; Sandimmune; SangCyA; Atopica. Grades: >98%. CAS No. 79217-60-0. Molecular formula: C62H111N11O12. Mole weight: 1202.61. | |
| Danshensu | Danshensu is an active component of Salvia miltiorrhiza that shows wide cardiovascular benefit. It suppresses the formation of reactive oxygen species and inhibits platelet adhesion and aggregation. It also protects myocardium from the reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. It increases production of collagenin Detroit 551 cells and attenuates the α-MSH-stimulated melanin production of B16 cells. It may be used as active ingredients in would healing, cosmetic treatments or treating hyperpigmentation. It significantly decreased the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size in vitro. It also had ROS scavenging activity and boosted endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which was mediated by Akt and ERK1/2 in western blot analysis. It significantly lowered tHcy in rats with elevated tHcy. Danshensu is a natural compound, which can also be used in cosmetics material. Synonyms: Benzenepropanoic acid, α,3,4-trihydroxy-, (αR)-; (αR)-α,3,4-Trihydroxybenzenepropanoic acid; Benzenepropanoic acid, α,3,4-trihydroxy-, (R)-; (R)-(+)-3-(3,4-Dihydroxyphenyl)lactic acid; (R)-3-(3,4-Dihydroxyphenyl)-2-hydroxypropionic acid; 3-(3',4'-Dihydroxyphenyl)-(2R)-lactic acid; D-(+)-β-(3,4-Dihydroxyphenyl)lactic acid; Dan Shen Su; Dan shen suan A; DS 182; Salianic acid A; Salvianic acid A; Tanshinol. Grades: >98%. CAS No. 76822-21-4. Molecular formula: C9H10O5. Mole weight: 198.17. | |
| D-dopachrome decarboxylase | This enzyme is specific for D-dopachrome as substrate and belongs to the MIF (macrophage migration inhibitory factor) family of proteins. L-Dopachrome, L- or D-α-methyldopachrome and dopaminochrome do not act as substrates (see also EC 5.3.3.12, L-dopachrome isomerase). Group: Enzymes. Synonyms: phenylpyruvate tautomerase II; D-tautomerase;D-dopachrome tautomerase; D-dopachrome carboxy-lyase. Enzyme Commission Number: EC 4.1.1.84. CAS No. 184111-06-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4833; D-dopachrome decarboxylase; EC 4.1.1.84; 184111-06-6; phenylpyruvate tautomerase II; D-tautomerase;D-dopachrome tautomerase; D-dopachrome carboxy-lyase. Cat No: EXWM-4833. | |
| deoxyhypusine monooxygenase | The enzyme catalyses the final step in the formation of the amino acid hypusine in the eukaryotic initiation factor 5A. Group: Enzymes. Synonyms: deoxyhypusine hydroxylase; deoxyhypusine dioxygenase. Enzyme Commission Number: EC 1.14.99.29. CAS No. 101920-83-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1045; deoxyhypusine monooxygenase; EC 1.14.99.29; 101920-83-6; deoxyhypusine hydroxylase; deoxyhypusine dioxygenase. Cat No: EXWM-1045. | |
| deoxyhypusine synthase | The eukaryotic initiation factor eIF5A contains a hypusine residue that is essential for activity. This enzyme catalyses the first reaction of hypusine formation from one specific lysine residue of the eIF5A precursor. The reaction occurs in four steps: NAD+-dependent dehydrogenation of spermidine (1a), formation of an enzyme-imine intermediate by transfer of the 4-aminobutylidene group from dehydrospermidine to the active site lysine residue (Lys329 for the human enzyme; 1b), transfer of the same 4-aminobutylidene group from the enzyme intermediate to the e1F5A precursor (1c), reduction of the e1F5A-imine intermediate to form a deoxyhypusine residue (1d). Hence the overall reaction is transfer of a 4-aminobutyl group. For the plant enzyme, homospermidine can substitute for spermidine and putrescine can substitute for the lysine residue of the eIF5A precursor. Hypusine is formed from deoxyhypusine by the action of EC 1.14.99.29, deoxyhypusine monooxygenase. Group: Enzymes. Synonyms: spermidine:eIF5A-lysine 4-amino. Enzyme Commission Number: EC 2.5.1.46. CAS No. 127069-31-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2782; deoxyhypusine synthase; EC 2.5.1.46; 127069-31-2; spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming). Cat No: EXWM-2782. | |
| diphthine-ammonia ligase | This amidase catalyses the last step in the conversion of an L-histidine residue in the translation elongation factor EF2 to diphthamide. This factor is found in all archaebacteria and eukaryotes, but not in eubacteria, and is the target of bacterial toxins such as the diphtheria toxin and the Pseudomonas exotoxin A (see EC 2.4.2.36, NAD+-diphthamide ADP-ribosyltransferase). The substrate of the enzyme, diphthine, is produced by EC 2.1.1.98, diphthine synthase. Group: Enzymes. Synonyms: diphthamide synthase; diphthamide synthetase; DPH6 (gene name); ATPBD4 (gene name); diphthine:ammonia ligase (AMP-forming). Enzyme Commission Number: EC 6.3.1.14. CAS No. 114514-33-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5717; diphthine-ammonia ligase; EC 6.3.1.14; 114514-33-9; diphthamide synthase; diphthamide synthetase; DPH6 (gene name); ATPBD4 (gene name); diphthine:ammonia ligase (AMP-forming). Cat No: EXWM-5717. | |
| diphthine methyl ester synthase | This eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. Different from the archaeal enzyme, which performs only 3 methylations, producing diphthine (cf. EC 2.1.1.98). The relevant histidine of elongation factor 2 is His715 in mammals and His699 in yeast. The order of the 4 methylations is not known. Group: Enzymes. Synonyms: S-adenosyl-L-methionine:elongation factor 2 methyltransferase (ambiguous); diphthine methyltransferase (ambiguous); Dph5 (ambiguous). Enzyme Commission Number: EC 2.1.1.314. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1922; diphthine methyl ester synthase; EC 2.1.1.314; S-adenosyl-L-methionine:elongation factor 2 methyltransferase (ambiguous); diphthine methyltransferase (ambiguous); Dph5 (ambiguous). Cat No: EXWM-1922. | |
| diphthine synthase | This archaeal enzyme produces the trimethylated product diphthine, which is converted into diphthamide by EC 6.3.1.14, diphthine-ammonia ligase. Different from the eukaryotic enzyme, which produces diphthine methyl ester (cf. EC 2.1.1.314). In the archaeon Pyrococcus horikoshii the enzyme acts on His600 of elongation factor 2. Group: Enzymes. Synonyms: S-adenosyl-L-methionine:elongation factor 2 methyltransferase (ambiguous); diphthine methyltransferase (ambiguous); S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine-[translation elongation factor 2] methyltransferase; Dph5 (ambiguous). Enzyme Commission Number: EC 2.1.1.98. CAS No. 114514-25-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1998; diphthine synthase; EC 2.1.1.98; 114514-25-9; S-adenosyl-L-methionine:elongation factor 2 methyltransferase (ambiguous); diphthine methyltransferase (ambiguous); S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine-[translation elongation factor 2] methyltransferase; Dph5 (ambiguous). Cat No: EXWM-1998. | |
| DNA-directed RNA polymerase | Catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to α-amanitin, and the type of RNA synthesized. See also EC 2.7.7.19 (polynucleotide adenylyltransferase) and EC 2.7.7.48 (RNA-directed RNA polymerase). Group: Enzymes. Synonyms: RNA polymerase; RNA nucleotidyltransferas. Enzyme Commission Number: EC 2.7.7.6. CAS No. 9014-24-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3271; DNA-directed RNA polymerase; EC 2.7.7.6; 9014-24-8; RNA polymerase; RNA nucleotidyltransferase (DNA-directed); RNA polymerase I; RNA polymerase II; RNA polymerase III; C RNA formation factors; deoxyribonucleic acid-dependent ribonucleic acid polymerase; DNA-dependent ribonucleate nucleotidyltransferase; DNA-dependent RNA nucleotidyltransferase; DNA-dependent RNA polymerase; ribonucleate nucleotidyltransferase; ribonucleate polymerase; C ribonucleic acid formation factors; ribonucleic acid nucleotidyltransferase; ribonucleic acid polymerase; ribonucleic acid transcriptase; ribonucleic polymerase; ribonucleic transcriptase; RNA nucleotidyltransferase; RNA transcriptase; transcriptase; RNA nucleotidyltransferase I. | |
| EDA-m7GDP - ATTO-Rho6G | EDA-m7GDP - ATTO-Rho6G, a fluorescent-labeled probe, offers a valuable tool for exploring RNA capping enzymes and unraveling the intricacies of mRNA formation. With the capacity to identify factors integral to vital processes such as mRNA processing, translation initiation, and immune evasion, this discreet yet powerful resource is a must-have for any researcher seeking to expand knowledge in drug target discovery, drug development, and viral infection diagnostics. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-7-methyl-guanosine-5'-diphosphate, labeled with ATTO Rho6G, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C45H56N10O15P2(free acid). Mole weight: 1038.34 (free acid). | |
| elongation factor 2 kinase | Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+. Group: Enzymes. Synonyms: Ca/CaM-kinase III; calmodulin-dependent protein kinase III; CaM kinase III; eEF2 kinase; eEF2K; EF2K; STK19. Enzyme Commission Number: EC 2.7.11.20. CAS No. 116283-83-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3140; elongation factor 2 kinase; EC 2.7.11.20; 116283-83-1; Ca/CaM-kinase III; calmodulin-dependent protein kinase III; CaM kinase III; eEF2 kinase; eEF2K; EF2K; STK19. Cat No: EXWM-3140. | |
| Endoglycosidase S from Streptococcus pyogenes, Recombinant | Endoglycosidase S is specific for N-glycans attached on the Fc domain of IgGs. The N-glycan is cleaved after the first Glc-Nac. Reaction is mild and runs fast under physiological conditions without the need for co-factors or detergent. The enzyme only hydrolyze glycans from the Fc-domain of IgGs even if other glycosylated proteins are present in solution. Group: Enzymes. Synonyms: Endoglycosidase S; IgGZERO. Purity: > 95% homogeneity as determined by SDS-PAGE analysis. Endo-β-N-acetylglucosaminidase. Mole weight: 110 kDa. Stability: The enzyme is reconstituted by addition of water and after reconstitution it is stable for 1 month at +4-8°C. The enzyme can be aliquoted and stored at -20°C for at least 6 months. The product is shipped at ambient temperature but should be stored at -20°C upon arrival. Appearance: White to light yellow powder. Storage: at -20°C. Form: Lyophilized powder with no preservatives added. Source: E.coli. Species: Streptocoocus pyogenes. Endoglycosidase S; IgGZERO Enzyme; IgGZERO; Endoglycosidase. Cat No: NATE-1603. | |
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