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| Product | Description | |
|---|---|---|
| Fibroblast Growth Factor | Fibroblast Growth Factors are a family of cell signalling proteins produced by macrophages, consisting of 23 members in humans. They have various functions so that is involved in multiple processes, regulating fundamental developmental pathways. Synonyms: FGF. |  |
| Fibroblast Growth Factor-10 human | >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. |  |
| Fibroblast Growth Factor-18 human | >95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| FIBROBLAST GROWTH FACTOR-4 HUMAN RECOMBI | FIBROBLAST GROWTH FACTOR-4 HUMAN RECOMBI. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FIBROBLAST GROWTH FACTOR-4 HUMAN RECOMBI;fibroblast growth factor-4 human*recombinant cell;FIBROBLAST GROWTH FACTOR-4, HUMAN RECOMB INANT, CELL CULTURE TESTED. Product Category: Heterocyclic Organic Compound. CAS No. 123584-45-2. Product ID: ACM123584452. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Fibroblast Growth Factor-5 human | recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ?97% (SDS-PAGE and N-terminal analysis). Group: Fluorescence/luminescence spectroscopy. | |
| Fibroblast Growth Factor-8b from mouse | >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Fibroblast Growth Factor-9 human | recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, ?97% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Fibroblast Growth Factor-Acidic human | FGF-Acidic, recombinant, expressed in E. coli, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Fibroblast Growth Factor-Basic | Fibroblast Growth Factor-Basic is a growth factor encoded by the FGF2 gene. It is found in basement membranes and sub-endothelial extracellular matrix. FGF2 specifically binds to fibroblast growth factor receptor (FGFR) proteins. Synonyms: hBFGF; FGF-Basic; Basic fibroblast growth factor; bFGF. CAS No. 106096-93-9. | |
| Fibroblast Growth Factor-Basic from bovine pituitary | FGF-Basic, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Fibroblast Growth Factor-Basic Heparin Stabilized human | FGF-Basic, recombinant, expressed in E. coli, sterile-filtered, aqueous solution, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Fibroblast Growth Factor from bovine pituitary | suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Fibroblast Growth Factor Receptor-2? (IIIc)/Fc Chimera human | >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Acidic fibroblast growth factor intracellular-binding protein isoform a (169-179) | Acidic fibroblast growth factor intracellular-binding protein isoform a (169-179) is a peptide corresponding to residues 169-179 of Acidic fibroblast growth factor intracellular-binding protein isoform a. Acidic fibroblast growth factor intracellular-binding protein is involved in mitogenic function of FGF1. | |
| Anti-Fibroblast Growth Factor-9 antibody, Mouse monoclonal | clone FG9-77, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit | fractionated antiserum, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Fibroblast Growth Factor-Basic antibody, Mouse monoclonal | clone FB-8, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Fibroblast Growth Factor-Basic antibody produced in goat | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Fibroblast Growth Factor Receptor-1 antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Fibroblast Growth Factor Receptor-2, Cytoplasmic antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Fibroblast Growth Factor Receptor-2, Extracellular antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Fibroblast Growth Factor Receptor-3, Cytoplasmic antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Fibroblast Growth Factor-Basic antibody produced in mouse | clone 10060, purified immunoglobulin, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride | 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride is a potent and selective Smad3 inhibitor that attenuates transforming growth factor (TGF)- β1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4 (1). It also inhibits TGF- β1-induced myofibroblast differentiation of dermal fibroblasts and TGF- β2-induced endothelial cell differentiation in iPSCs (1,2). Group: Biochemicals. Grades: Highly Purified. CAS No. 521984-48-5. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C28H28ClN3O3, Molecular Weight: 489.99. US Biological Life Sciences. |  Worldwide |
| 1,2-bis(4-methylpiperazin-1-yl)ethanone | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Piperazine, 1-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-(5CI); Nintedanib Impurity E. Grades: ≥95%. CAS No. 856843-88-4. Molecular formula: C12H24N4O. Mole weight: 240.35. | |
| 1-Amino-1-deoxy-2,3,4-triacetate β-D-Glucopyranuronic Acid Methyl Ester | 1-Amino-1-deoxy-2,3,4-triacetate β-D-Glucopyranuronic Acid Methyl Ester is used in biological studies for the inhibitor identification of fibroblast growth factor (FGF-2) binding to heparin and endothelial cells. Synonyms: 1-Amino-1-deoxy-2,3,4-triacetate beta-D-Glucopyranuronic Acid Methyl Ester; 14365-73-2. CAS No. 14365-73-2. Molecular formula: C13H19NO9. Mole weight: 333.29. | |
| 2,2'-(piperazine-1,4-diyl)bis(N-methyl-N-(4-nitrophenyl)acetamide) | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Nintedanib Impurity G. Grades: ≥95%. CAS No. 2410649-54-4. Molecular formula: C22H26N6O6. Mole weight: 470.48. | |
| 2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: 4-Methyl-N-(4-nitrophenyl)-1-piperazineacetamide; Nintedanib Impurity F. Grades: ≥95%. CAS No. 708279-23-6. Molecular formula: C13H18N4O3. Mole weight: 278.31. | |
| 2,5-Dihydroxybenzoic acid | 2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors. Uses: Scientific research. Group: Natural products. Alternative Names: Gentisic acid. CAS No. 490-79-9. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W001179. |  |
| 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Acetamide, 2-chloro-N-methyl-N-(4-nitrophenyl)-; α-Chloro-N-methyl-p-nitroacetanilide; Nintedanib Impurity B. Grades: ≥95%. CAS No. 2653-16-9. Molecular formula: C9H9ClN2O3. Mole weight: 228.63. | |
| 3-Chloro-4-(4-methyl-1-piperazinyl)benzoic Acid | 3-Chloro-4-(4-methyl-1-piperazinyl)benzoic acid acts as a reagent in the preparation of 1H-pyrazolo[3,4-b]pyridines as fibroblast growth factor receptor inhibitors (FGFRs). Fibroblast growth factor receptors are important targets for cancer therapy. Group: Biochemicals. Grades: Highly Purified. CAS No. 1197193-33-1. Pack Sizes: 25mg, 50mg. Molecular Formula: C12H15ClN2O2, Molecular Weight: 254.71. US Biological Life Sciences. | Worldwide |
| (3Z)-2,3-Dihydro-2-oxo-3-(phenyl-1-piperidinylmethylene)-1H-indole-6-carboxylic acid methyl ester | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Nintedanib Impurity U. Grades: ≥95%. CAS No. 2102162-79-6. Molecular formula: C22H22N2O3. Mole weight: 362.42. | |
| ABT-510 | ABT-510 is a synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8). Synonyms: ABT-510; ABT 510; ABT510. CAS No. 251579-55-2. Molecular formula: C46H83N13O11. Mole weight: 994.25. | |
| Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde | Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde, a potent and reversible caspase-8 inhibitor, enables cell permeability by linking to a nonpolar CPP corresponding to the Kaposi fibroblast growth factor (FGF) signaling peptide sequence. Synonyms: Caspase-8 Inhibitor I, Cell Permeable; N-Acetyl-L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-isoleucyl-L-α-glutamyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-threoninamide; N-Acetyl-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-al; L-Threoninamide, N-acetyl-L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-. Grades: ≥95%. CAS No. 886462-83-5. Molecular formula: C95H162N20O26. Mole weight: 2000.42. | |
| AGI-B4 | AGI-B4 is a substance produced by Aspergillus sp. Y80118 that inhibits the growth of endothelial cells. It inhibits the proliferation of human umbilical vein endothelial cells (HUVECs) induced by vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and endothelial cell growth factor (ECGS) with IC50 of 1.4 μmol/ L, 2.8 μmol/L and 6.2 μmol/L. Synonyms: (7R,8R)-AGI-B4. CAS No. 1313588-44-1. Molecular formula: C16H14O7. Mole weight: 318.28. | |
| Aldafermin | Aldafermin (NGM282) is an analog of fibroblast growth factor 19. Aldafermin can be used for the research of nonalcoholic steatohepatitis (NASH) [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: NGM282. CAS No. 1616639-03-2. Pack Sizes: 500 μg; 1 mg. Product ID: HY-P99428. | |
| Alofanib | Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 ( FGFR2 ). Anticancer and antiangiogenic activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RPT835. CAS No. 1612888-66-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17601. | |
| α-Tocotrienol | α-Tocotrienol is a form of vitamin E, a class of eight fat-soluble compounds. It was shown to induce apoptosis and inhibit proliferation, and down-regulate the fibroblast growth factor receptor-1 (FGFR1). Uses: Antioxidants. Synonyms: (2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol. CAS No. 58864-81-6. Molecular formula: C29H44O2. Mole weight: 424.7. | |
| ARQ-087 | ARQ-087, also known as Derazantinib, is an oral fibroblast growth factor receptor (FGFR) inhibitor with antitumor property. FGFR plays a role in the regulation of key cellular behaviors including proliferation, cell differentiation and so on. FGFR dysregulation is considered as a driver in multiple cancers. ARQ 087 binds to FGFR and effectively inhibits the activation of FGFR thus can suppress tumorigenesis and tumor growth. Synonyms: ARQ 087; ARQ087; ARQ-087; Derazantinib; (6R)-6-(2-fluorophenyl)-N-[3-[2-(2-methoxyethylamino)ethyl]phenyl]-5,6-dihydrobenzo[h]quinazolin-2-amine. Grades: ≥98%. CAS No. 1234356-69-4. Molecular formula: C29H29FN4O. Mole weight: 468.576. | |
| AZD-4547 | AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. Synonyms: AZD-4547; AZD 4547; AZD4547; N-{3-[2-(3,5-Dimethoxyphenyl)ethyl]-1h-Pyrazol-5-Yl}-4-[(3r,5s)-3,5-Dimethylpiperazin-1-Yl]benzamide. Grades: 98%. CAS No. 1035270-39-3. Molecular formula: C26H33N5O3. Mole weight: 463.582. | |
| BCI | BCI is an allosteric inhibitor of dual-specificity phosphatases (DUSP). BCI treatment of DUSP6-Myc-transfected cells suppresses DUSP6 or DUSP1 activity. BCI induces expansion of myocardial progenitors that ultimately increases heart size in zebrafish embryos via inhibiting DUSP6. BCI also inhibits lung cancer and uveal melanoma cells viability (IC50 = 0.1 to 90 μM). DUSP6 functions a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal-regulated kinases (ERKs) 1 and 2. Synonyms: (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one; (2E)-2-Benzylidene-3-(cyclohexylamino)-1-indanone. Grades: 99%. CAS No. 1245792-51-1. Molecular formula: C22H23NO. Mole weight: 317.42. | |
| Bemarituzumab | Bemarituzumab is a first-in-class, humanized IgG1 monoclonal antibody against FGFR2b (a FGF receptor). Bemarituzumab blocks fibroblast growth factors from binding and activating FGFR2b. Bemarituzumab has the potential for cancer research [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1952272-74-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99010. | |
| BGJ-398 | BGJ398, also known as NVP-BGJ398, is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Synonyms: 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea; NVPBGJ398; NVPBGJ 398; NVPBGJ-398; BGJ398; BGJ-398; BG J398; Infigratinib. Grades: 0.98. CAS No. 872511-34-7. Molecular formula: C26H31Cl2N7O3. Mole weight: 560.48. | |
| BLU-554 | BLU-554 is a potent and selective inhibitor of fibroblast growth factor receptor 4 (FGFR4) (IC50 = 5 nM), which is promisingly to be used for the treatment of hepatocellular carcinoma and cholangiocarcinoma. Synonyms: BLU-554; BLU 554; BLU554, Fisogatinib; SCHEMBL16668287; EX-A841; MFCD30496704; N-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]oxan-4-yl]prop-2-enamide; BLU554. Grades: 99.08 %. CAS No. 1707289-21-1. Molecular formula: C24H24Cl2N4O4. Mole weight: 503.38. | |
| BMS-195270 | BMS-195270 is a robust and discriminating small molecule inhibitor, finding paramount application in the biomedical sector. Its remarkable efficacy against fibroblast growth factor receptor 4 (FGFR4) imparts exceptional potency, rendering it a formidable intervention modality for malignancies driven by FGFR4. Synonyms: 2-(5-chloro-2-hydroxyphenyl)-5-[2-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-one; BMS-195270; BMS 195270; BMS195270; UNII-20UM0T170J; CHEMBL13637; SCHEMBL5754043; 20UM0T170J. Grades: >98%. CAS No. 202822-23-9. Molecular formula: C15H9ClF3N3O2. Mole weight: 355.7. | |
| BMS-645737 | BMS-645737 is an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor (FGF) receptor-1. BMS-646737 has anti-angiogenic activity and was evaluated in nonclinical studies as a treatment for cancer. Synonyms: BMS645737; BMS 645737; 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine. Grades: >98%. CAS No. 651744-16-0. Molecular formula: C20H20N8O. Mole weight: 388.43. | |
| Burosumab | Burosumab is a human fibroblast growth factor 23 (FGF23) neutralizing antibody that can be used for the research of X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: KRN23. CAS No. 1610833-03-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9939. | |
| Burosumab | Burosumab is a human monoclonal antibody targeting the phosphaturic hormone fibroblast growth factor 23 (FGF23). Burosumab is currently in a phase III clinical trial for the treatment of patients with X-linked hypophosphatemia. Uses: The potential treatment of x-linked hypophosphatemia. Synonyms: KRN-23; KRN 23; KRN23. CAS No. 1610833-03-8. | |
| CHIR-99021 | A potent and highly selective inhibitor of glycogen synthase kinase-3beta (GSK-3b) (IC50 = 6.7nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a chemically-defined medium in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402. Group: Biochemicals. Alternative Names: 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2- yl) pyrimidin-2-yl) amino) ethyl) amino) nicotinonitrile; CT99021; CHIR 911. Grades: Highly Purified. CAS No. 252917-06-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CP-547632 | CP-547632 is as a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 11 and 9 nM, respectively). It is selective relative to epidermal growth factor receptor, platelet-derived growth factor , and other related TKs. It also inhibits VEGF-stimulated autophosphorylation of VEGFR-2 in a whole cell assay with an IC50 value of 6 nM. After oral administration of CP-547,632 to mice bearing NIH3T3/H-ras tumors, VEGFR-2 phosphorylation in tumors was inhibited in a dose-dependent fashion (EC50 590 ng/ml). CP-547,632 is a well-tolerated, orally-bioavailable inhibitor presently under clinical investigation for the treatment of human malignancies. Synonyms: CP547632; CP 547632; CP-547632; PAN90806; PAN 90806; PAN-90806; CP632; OSI632; CP 632; OSI 632; CP-632; OSI-632. CAS No. 252003-65-9. Molecular formula: C20H24BrF2N5O3S. Mole weight: 532.405. | |
| D-alpha-Tocopherol Succinate | D-alpha-Tocopherol Succinate is the salt form of vitamin E, a class of eight fat-soluble compounds. It was shown to induce apoptosis and inhibit proliferation, and down-regulate the fibroblast growth factor receptor-1 (FGFR1). Vitamin supplement in health care products. Uses: Ingredient of health care products. Synonyms: Vitamin E succinate; Alpha-Tocopheryl succinate; D-; 4-oxo-4-[[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl]oxy]butanoic acid. Grades: 95%. CAS No. 4345-3-3. Molecular formula: C33H54O5. Mole weight: 530.79. | |
| Debio-1347 | Debio-1347, also known as FF284 and CH5183284, is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. FGFR inhibitor debio 1347 binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, is essential for tumor cellular proliferation, differentiation and survival. Synonyms: Debio-1347; Debio 1347; Debio1347; CH5183284; CH 5183284; CH-5183284; FF-284; FF284; FF 284. CAS No. 1265229-25-1. Molecular formula: C20H16N6O. Mole weight: 356.389. | |
| Derazantinib dihydrochloride | Derazantinib is an oral fibroblast growth factor receptor (FGFR) inhibitor with antitumor property. FGFR plays a role in the regulation of key cellular behaviors including proliferation, cell differentiation and so on. FGFR dysregulation is considered as a driver in multiple cancers. Derazantinib binds to FGFR and effectively inhibits the activation of FGFR thus can suppress tumorigenesis and tumor growth. Synonyms: Derazantinib hydrochloride; ARQ-087 dihydrochloride; ARQ-087 hydrochloride; ARQ-087 2HCl; ARQ 087 2HCl. CAS No. 1821329-75-2. Molecular formula: C29H31Cl2FN4O. Mole weight: 541.49. | |
| Dermatan Sulfate, Porcine Intestinal Mucosa - CAS 54328-33-5 | Mucopolysaccharide containing iduronic acid. Shown to inhibit adenylate kinase from rat hepatic membranes and acts as a potent mediator of fibroblast growth factor-2 responsiveness. Group: Fluorescence/luminescence spectroscopy. | |
| D-γ-Tocotrienol | γ-Tocotrienol is a form of vitamin E, a class of eight fat-soluble compounds. It was shown to induce apoptosis and inhibit proliferation, and down-regulate the fibroblast growth factor receptor-1 (FGFR1). Synonyms: [R-(E,E)]-3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol; (2R)-3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol; 2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-6-chromanol; (2R)-3,4-Dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl]-2H-1-benzopyran-6-ol; (R)-γ-Tocotrienol; 7,8-Dimethyltocotrienol; Plastochromanol 3; γ-Tocotrienol. CAS No. 14101-61-2. Molecular formula: C28H42O2. Mole weight: 410.63. | |
| Dimethyl 3, 3'- ( ( ( ( (2, 2'- (piperazine-1, 4-diyl)bis (acetyl))bis (methylazanediyl))bis (4, 1-phenylene))bis (azanediyl))bis (phenylmethanylylidene)) (3Z, 3'E)-bis (2-oxoindoline-6-carboxylate) | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Nintedanib Impurity 50. Grades: ≥95%. CAS No. 2410284-90-9. Molecular formula: C56H52N8O8. Mole weight: 965.08. | |
| Erdafitinib | Erdafitinib, also known as JNJ-42756493, is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Synonyms: JNJ-42756493; JNJ 42756493; JNJ42756493; Erdafitinib. Grades: 98%. CAS No. 1346242-81-6. Molecular formula: C25H30N6O2. Mole weight: 446.55. | |
| ERK5-IN-2 | ERK5-IN-2 is a submicromolar selective ERK5 inhibitor with oral activity, which can inhibit tumor xenograft growth and basic fibroblast growth factor (bFGF)-driven Matrigel plug angiogenesis. Synonyms: 4-(2-Bromanyl-6-Fluoranyl-Phenyl)Carbonyl-{N}-Pyridin-3-Yl-1{H}-Pyrrole-2-Carboxamide; SCHEMBL17607180; BCP32587; EX-A4938. Grades: 98%. CAS No. 1888305-96-1. Molecular formula: C17H11BrFN3O2. Mole weight: 388.2. | |
| Ferulic acid | Ferulic acid is a novel fibroblast growth factor receptor 1 ( FGFR1 ) inhibitor with IC 50 s of 3.78 and 12.5 μM for FGFR1 and FGFR2 , respectively. Uses: Scientific research. Group: Natural products. Alternative Names: Coniferic acid. CAS No. 1135-24-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g; 5 g. Product ID: HY-N0060. | |
| Ferulic acid sodium | Ferulic acid sodium is a novel fibroblast growth factor receptor 1 ( FGFR1 ) inhibitor with IC 50 s of 3.78 and 12.5 μM for FGFR1 and FGFR2 , respectively. Uses: Scientific research. Group: Natural products. Alternative Names: Coniferic acid sodium. CAS No. 24276-84-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g; 5 g. Product ID: HY-N0060A. | |
| FGF-401 | FGF-401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4) (IC50 = 1.9 nM) developed for the treatment of solid tumor. Synonyms: FGF401; FGF-401; FGF 401; roblitinib; N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide. CAS No. 1708971-55-4. Molecular formula: C25H30N8O4. Mole weight: 506.56. | |
| FIIN-1 | FIIN-1 is a potent, irreversible and selective FGFR inhibitor with IC50s of 9.2, 6.2, 11.9 and 189 nM against FGFR1/2/3/4, respectively. FIIN-1 binds to FGFR1/2/3/4 and Flt1/4 with Kds of 2.8, 6.9, 5.4, 120 nM and 32, 120 nM, respectively. Synonyms: FGFR irreversible inhibitor-1; N-[3-[[3-(2,6-Dichloro-3,5-dimethoxyphenyl)-7-[[4-(diethylamino)butyl]amino]-3,4-dihydro-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-2-propenamide; Fibroblast Growth Factor Receptor Irreversible Inhibitor 1; N-[3-[[3-(2,6-Dichloro-3,5-dimethoxyphenyl)-7-[[4-(diethylamino)butyl]amino]-3,4-dihydro-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]acrylamide. Grades: ≥95%. CAS No. 1256152-35-8. Molecular formula: C32H39Cl2N7O4. Mole weight: 656.60. | |
| Fisogatinib | Fisogatinib (BLU-554) is a potent, highly selective and orally active fibroblast growth factor receptor 4 (FGFR4) inhibitor with an IC 50 of 5 nM. Fisogatinib has significant anti-tumor activity in models of hepatocellular carcinoma (HCC) that are dependent on FGFR4 signalling [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BLU-554. CAS No. 1707289-21-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100492. | |
| Futibatinib | Futibatinib is an orally bioavailable, selective and irreversible inhibitor of fibroblast growth factor receptors (FGFRs), displaying antineoplastic activity. It inhibits FGFR-mediated signal transduction and tumor cell proliferation. Synonyms: 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1-pyrazolo[3,4-d]pyrimidinyl]-1-pyrrolidinyl]-2-propen-1-one; 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]pyrazolo[3,4-d]pyrimidin-1-yl]pyrrolidin-1-yl]prop-2-en-1-one. Grades: ≥ 98 %. CAS No. 1448169-71-8. Molecular formula: C22H22N6O3. Mole weight: 418.45. | |
| Gimatecan | Gimatecan is an orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic and antiangiogenic activities. Gimatecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Although the mechanism of its antiangiogenic activity has yet to be full elucidated, this agent may inhibit endothelial cell migration, tumor neovascularization, and the expression of proangiogenic basic fibroblast growth factor (bFGF). Synonyms: ST1481; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-(O-(1,1-dimethylethyl)oxime), (C(E),4S)-; 7-t-Butoxyiminomethylcamptothecin; (4S)-11-((E)-((1,1-DImethylethoxy)imino)methyl)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione; NSC793724. Grades: ≥98%. CAS No. 292618-32-7. Molecular formula: C25H25N3O5. Mole weight: 447.48. | |
| H-Ala-ala-val-ala-leu-leu-pro-ala-val-leu-leu-ala-leu-leu-ala-pro-val-gln-arg-lys-arg-gln-lys-leu-met-pro-oh | H-Ala-ala-val-ala-leu-leu-pro-ala-val-leu-leu-ala-leu-leu-ala-pro-val-gln-arg-lys-arg-gln-lys-leu-met-pro-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FGF-4 PRECURSOR (7-22) (HUMAN)-EBP-1 (359-368) (HUMAN);FIBROBLAST GROWTH FACTOR-4 PRECURSOR (7-22) (HUMAN)-NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT (359-368) (HUMAN);H-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-VAL-GLN-ARG-LYS-ARG-GLN-. Product Category: Heterocyclic Organic Compound. CAS No. 213546-53-3. Molecular formula: C129H230N36O29S. Mole weight: 2781.5. Product ID: ACM213546533. Alfa Chemistry ISO 9001:2015 Certified. | |
| K-FGF | It is a cell penetrating peptide. Synonyms: H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-OH; Human FGF-4; hFGF-4; Heparin-binding growth factor 4; K-fibroblast growth factor; HBGF-4; transforming protein KS3; L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-proline. Grades: >98%. Molecular formula: C74H130N16O17. Mole weight: 1515.95. | |
| Lucitanib | Lucitanib, also known as E-3810, is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types. Synonyms: E3810; E-3810; E 3810; AL3810; AL 3810; AL-3810; Lucitanib. CAS No. 1058137-23-7. Molecular formula: C26H25N3O4. Mole weight: 443.503. | |
| Membrane-Permeable Sequence, MPS | It corresponds to the membrane-permeable sequence designed from the carboxyl terminus of Gα subunits targeting G protein subunits. It is a membrane-translocating hydrophobic sequence specifically derived from the h-region of K-FGF (Kaposi fibroblast growth factor) signal peptide sequence. Synonyms: H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Lys-OH. Grades: >98%. Molecular formula: C75H135N17O17. Mole weight: 1547.01. | |
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