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Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels , with IC 50 of 1.95 nM and 225 nM for M. domestica GABACls and GluCls. Uses: Scientific research. Group: Signaling pathways. CAS No. 928783-29-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108690.
Fluxapyroxad
Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. It works by inhibiting succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 907204-31-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-135549.
Foundry Fluxes
Foundry Fluxes (blended, fused and granular). We offer a variety of products for diverse applications and maintain an extensive inventory at our warehouses to provide prompt shipment and on-time delivery to our customers.
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MattifluxFlux Powder
MattifluxFlux Powder. Group: Alloys.
Silver, brazing flux, white paste
Silver, brazing flux, white paste. Group: Alloys.
Soldering flux, liquid
Soldering flux, liquid. Group: Alloys.
Tenacity No. 125 Flux Powder, working range 750-1200°C (1382-2102°F)
Tenacity No. 125 Flux Powder, working range 750-1200°C (1382-2102°F). Group: Alloys.
Tenacity No. 125 Paste, a high temperature flux paste, working range 800-1100°C (1472-2012°F)
Tenacity No. 125 Paste, a high temperature flux paste, working range 800-1100°C (1472-2012°F). Group: Alloys.
Tenacity No. 6 Flux Powder
Tenacity No. 6 Flux Powder. Group: Alloys.
13,14-dihydro-15-keto prostaglandin D2
13,14-dihydro-15-keto prostaglandin D2 is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. It has been recently identified as a selective agonist for the DP2 receptor. Additionally, 13,14-dihydro-15-keto Prostaglandin D2 has been shown to inhibit ion flux in canine colonic mucosa preparation. Synonyms: 13,14-dihydro-15-keto PGD2; 11,15-dioxo-9S-hydroxy-5Z-prostenoic acid; (Z)-7-[(1R,2R,5S)-5-hydroxy-3-oxo-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid. Grades: ≥95%. CAS No. 59894-07-4. Molecular formula: C20H32O5. Mole weight: 352.5.
2-Methylthio-ADP Trisodium Salt
2-Methylthio-ADP trisodium salt is a P2Y1, P2Y12 and P2Y13 agonist. It is used in biological study of activation of P2Y1 P2Y12 and P2Y13 protein promoted purinergic ATP signal transduction mediated calcium flux in podocyte isolated from rat glomerulus. Group: Biochemicals. Alternative Names: 2-(Methylthio)adenosine 5'-Diphosphate Trisodium Salt; 2-MeSADP; 2-Methylthio-ADP. Grades: Highly Purified. CAS No. 475193-31-8. Pack Sizes: 10mg. Molecular Formula: C??H??N?Na?O??P?S, Molecular Weight: 539.24. US Biological Life Sciences.
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3,4-Dimethoxychalcone
3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5416-71-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W083373A.
6-Azuridine
6-Azuridine (6-Azauridine) is an orally active purine nucleoside analogue. 6-Azuridine activates autophagic flux , induces Apoptosis that depends on AMPK and p53. 6-Azuridine exhibit both antitumor and antiviral activities [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 6-Azauridine. CAS No. 54-25-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-131611.
7ACC2
7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux. Synonyms: 7ACC2; 7 ACC2; 7-ACC2. Grades: >98%. CAS No. 1472624-85-3. Molecular formula: C18H15NO4. Mole weight: 309.32.
A potent, selective, and competitive non-nucleotide antagonist of P2X3 and P2X2/3 receptors that blocks receptor-mediated Ca2+ flux (Ki = 22 and 92nM for rat P2X3 and P2X2/3 receptor and 22 and 9nM for human P2X3 and P2X2/3 receptor, respectively). Its R-enantiomer has significantly reduced activity at these receptors. Exhibits high selectivity over other purinergic receptors. Shown to reduce thermal and mechanical hyperalgesia in rat models (ED50 = 10-15uM/kg, s.c). Its anti-nociceptive effects have a rapid on-set and persist for up to 5 hours after sub-cutaneous administration. Also shown to block dorsal root ganglion currents in a dose-dependent manner (IC50 = 15nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 475205-49-3. Pack Sizes: 5mg. Molecular Formula: C??H??NO? xH2O xNa. US Biological Life Sciences.
A highly potent, selective, competitive antagonist of P2X7 purinegic receptor (IC50 = 18nM and 40nM, respectively as measured by Bz-ATP-stimulated Ca2+ flux). Does not affect other P2 receptors even at 10uM concentrations. Blocks agonist-evoked IL-1b release (IC50 = 156nM) and pore formation (IC50 = 92nM) in differentiated human THP-1 cells. Also shown to reduce carrageenan and Freund's adjuvant -induced thermal hyperalgesia (ED50 = 38-54mg/kg, i.p) and neuropathic pain induced by chronic constriction injury (CIC) of the sciatic nerve. Group: Biochemicals. Grades: Highly Purified. CAS No. 861393-28-4. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?, Primary Target: P2X7. US Biological Life Sciences.
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AF 353
AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. It is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. It also blocks human P2X2/3 channel function with marginally reduced potency (pIC50 = 7.3). It significantly reduces this parameter in both groups. It also reduces the inter-contractile interval in control but not in SCI rats. Synonyms: AF353; AF-353; 2,4-Pyrimidinediamine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-; Ro 4; 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyrimidinediamine. Grades: >98%. CAS No. 865305-30-2. Molecular formula: C14H17IN4O2. Mole weight: 400.21.
A novel, potent, orally bioavailable antagonist of P2X3/P2X2/3 receptors (pIC50 = 8 in human and rat; pIC50 = 7.3 for human P2X2/3 receptor). Shown to be highly brain penetrant with a brain to plasma ratio of 6. Blocks agonist-evoked intracellular Ca2+ flux and inward currents in nanomolar range (10nM to 1uM) in cell lines recombinantly expressing human P2X3 and P2X2/3 receptors. Exhibits desirable pharmacokinetic properties (t1/2 = 1.63 h and Tmax = 30 min). Group: Biochemicals. Grades: Highly Purified. CAS No. 927887-18-1. Pack Sizes: 5mg. Molecular Formula: C??H??ClIN?O?. US Biological Life Sciences.
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Aluminium phosphate
Aluminium phosphate occurs in nature as the mineral, berlinite. Also, it occurs in nature in minerals, amblygonite, [NaAl(PO4)(OH)]; augelite, [Al2(PO4)(OH)3]; lazulite, [(Mg,Fe)Al2(PO4)2(OH)2]; variscite [(Al,Fe3+)(PO4) 2H2O]; and wavellite, [Al3(OH)3 (PO4)2 5H2O]. It is used as flux for ceramics; as cement in combination with calcium sulfate and sodium silicate; and in the manufacture of special glasses. It is also used in dried gel and therapeutically as an antacid. Product ID: PE-0677. Molecular formula: AlPO4. Mole weight: 121.9529. Category: Antacid; vaccine adjuvant. Product Keywords: Vaccine Adjuvants; PE-0677; Aluminium phosphate. Chemical Name: Aluminium phosphate. Grade: Pharmaceutical grade. Administration route: Accepted for use in human and veterinary vaccines. Dosage Form: Accepted for use in human and veterinary vaccines. Stability and Storage Conditions: Aluminum phosphate adjuvant is stable for at least 2 years when stored at 4-308°C in well-sealed inert containers. It must not be allowed to freeze as the hydrated colloid structure will be irreversibly damaged. Source and Preparation: Aluminum phosphate adjuvant is formed by the reaction of a solution of aluminum chloride and phosphoric acid with alkali hydroxide. Applications: Aluminum Phosphate is an odorless, white crystalline solid which is often used in liquid or gel form. It is used in ceramics, dental cements, cosmetics, paints, paper an
AM095
AM095 is a selective LPA 1 receptor antagonist. The IC 50 for AM095 antagonism of LPA-induced calcium flux of human or mouse LPA 1 -transfected CHO cells is 0.025 and 0.023 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1345614-59-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-16039.
AM095 sodium
AM095 is a selective LPA1 receptor antagonist. The IC50 for AM095 antagonism of LPA-induced calcium flux of human or mouse LPA1-transfected CHO cells is 0.025 and 0.023 μM, respectively. Synonyms: AM-095 sodium; AM 095 sodium. Grades: >98%. CAS No. 1345614-59-6. Molecular formula: C27H23N2NaO5. Mole weight: 478.48.
AMD3465 hexahydrobromide
AMD 3465 is a potent and selective antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells. AMD 3465 (50 nM) totally blocks CXCL12-induced calcium mobilization, with an IC50 of 17 nM, but shows no effect on the intracellular calcium fluxes elicited by the CCR5 ligands RANTES, LD78β and MIP-1β in U87.CD4.CCR5 cells. MD3465 was even 10-fold more effective as a CXCR4 antagonist, while showing no interaction whatsoever with CCR5. AMD3465 has the potential to mobilize hematopoietic stem cells. Synonyms: AMD3465; GENZ-644494 hexahydrobromide. Grades: ≥95%. CAS No. 185991-07-5. Molecular formula: C24H38N6·6HBr. Mole weight: 896.07.
AMG 837
AMG 837 sodium salt is a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. It displayed the expected two-fold increase in potency on GPR4 compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40. It is a highly potent stimulator of insulin secretion in MIN6 cells with an EC50 comparable to that seen in the aequorin Ca2+-flux assay. It was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Synonyms: AMG-837, AMG837, AMG 837. Grades: >98%. CAS No. 865231-46-5. Molecular formula: C26H21F3O3. Mole weight: 438.44.
AMG 837 sodium salt
AMG 837 sodium salt is a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. It displayed the expected two-fold increase in potency on GPR4 compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40. It is a highly potent stimulator of insulin secretion in MIN6 cells with an EC50 comparable to that seen in the aequorin Ca2+-flux assay. It was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Synonyms: AMG-837 sodium; AMG837 sodium; AMG 837 sodium; AMG-837 sodium salt. Grades: >98%. CAS No. 865231-45-4. Molecular formula: C26H20F3NaO3. Mole weight: 460.42.
Ammonium Chloride
White crystalline salt, soluble in water. Uses: fertilizers, batteries, flux in metalwork. Group: halide salt. Alternative Names: Sal Ammoniac. CAS No. 12125-02-9.
Anhydrous Borax
Sodium Tetraborate, is an important boron compound, which has a wide variety of applications. It is a component of many detergents, cosmetics, and enamel glazes. It is also used to make buffer solutions in biochemistry, as a fire retardant, as an anti-fungal compound for fiberglass, as a flux in metallurgy, neutron-capture shields for radioactive sources, a texturing agent in cooking, and as a precursor for other boron compounds. Synonyms: Anhydrous borax; anhydrousborax; Antipyoninum; B4-Na2-O7; borates,tetra,sodiumsalt,anhydrous; borates, tetra, sodiumsalts(anhydrous); borates, tetra, sodiumsalts(pentahydrate); borax(anhydrous). Grades: fused. CAS No. 1330-43-4. Molecular formula: Na2B4O7. Mole weight: 201.21.
BI 639667
BI 639667 (compound 19n), a third azaindazole series compound, is a CCR1 antagonist, with an IC 50 of 1.8 nM in Ca 2+ flux assay [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCR1 antagonist 8. CAS No. 1295298-26-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-120588.
BMS-935177
BMS-935177 is a potent and selective reversible inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of 3 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective. BMS-935177 inhibited calcium flux in human Ramos B cells with IC50 of 27 nM and inhibited CD69 surface expression in peripheral B cells stimulated with anti-IgM and anti-IgG. Synonyms: BMS-935177; BMS935177. Grades: ≥98%. CAS No. 1231889-53-4. Molecular formula: C31H26N4O3. Mole weight: 502.56.
Boric Acid Granular
Boric acid granular, alternately termed orthoboric acid and boracic acid, is a naturally existing compound encompassing the elements boron, oxygen, and hydrogen, denoted chemically as (H3BO3). This substance is harnessed as a fluxing agent and frequently employed as a natural insect repellent as well. Uses: Adhesives & Cements, Corrosion Inhibitors, Electroplating, Paint & Coatings, Pest Control. Alternative Names: Orthoboric Acid. CAS No. 10043-35-3. Pack Sizes: 50lb.
USA
Boric anhydride
Boric anhydride. Uses: Boron oxide was used as the intermediate glass layer at a bonding temperature of 450°c. in preparation of fluxes; component of enamels and glass; catalyst in organic reaction. in metallurgy; in analysis of silicates to determine sio2 and alkalies; in blowpipe analysis. Group: Electronic materials. Alternative Names: Boric anhydride, 99.98% trace metals basis; JKWMSGQKBLHBQQ-UHFFFAOYSA-N; Diboron trioxide; Boric anhydride, purum p.a., >=97.0% (T); CHEBI:30163; boron(III) oxide; Boric anhydride, puriss. p.a., >=98% (T); AKOS015903863; FT-0694863; Boric anhydride, Vetec(TM) reagent grade, 98%. CAS No. 1303-86-2. Product ID: oxo(oxoboranyloxy)borane. Molecular formula: 69.617g/mol. Mole weight: B2O3;B2O3;B2O3. B(=O)OB=O. InChI=1S/B2O3/c3-1-5-2-4. JKWMSGQKBLHBQQ-UHFFFAOYSA-N.
Boric anhydride
Boron oxide was used as the intermediate glass layer at a bonding temperature of 450°C. In preparation of fluxes; component of enamels and glass; catalyst in organic reaction. In metallurgy; in analysis of silicates to determine SiO2 and alkalies; in blowpipe analysis. Group: Nanoparticles & nanopowders. Alternative Names: Boric anhydride, 99.98% trace metals basis; JKWMSGQKBLHBQQ-UHFFFAOYSA-N; Diboron trioxide; Boric anhydride, purum p.a., >=97.0% (T); CHEBI:30163; boron(III) oxide; Boric anhydride, puriss. p.a., >=98% (T); AKOS015903863; FT-0694863; Boric anhydride, Vetec(TM) reagent grade, 98%. CAS No. 1303-86-2. Molecular formula: B2O3;B2O3;B2O3. Mole weight: 69.617g/mol. IUPACName: oxo(oxoboranyloxy)borane. Canonical SMILES: B(=O)OB=O. Density: 2.46 (NIOSH, 2016);1.8 g/cu cm (amorphous); 2.46 g/cu cm (crystal);Relative density (water = 1): 2.46 (cryst);2.46;2.46. ECNumber: 215-125-8. Catalog: ACM1303862.
Boron Trioxide
Boron oxide appears as colorless, semi-transparent glassy lumps or hard white odorless crystals. Mp 450°C; bp: 1860°C. Density: 2.46 g cm-3. Moderately soluble in water. Used as an insecticide; as the starting material for the synthesis of other boron compounds; as a fluxing agent in enamels and glasses; and in mixture with 2-6% boron nitride, as a bonding agent in the hot isostatic pressing of boron nitride ceramics.;DryPowder; DryPowder, PelletsLargeCrystals; PelletsLargeCrystals;WHITE HYGROSCOPIC POWDER OR GRANULES;Colorless, semitransparent lumps or hard, white, odorless crystals.;Colorless, semitransparent lumps or hard, white, odorless crystals. Group: Glass additives. Product ID: oxo(oxoboranyloxy)borane. Molecular formula: 69.63g/mol. Mole weight: B2O3;B2O3;B2O3. B(=O)OB=O. InChI=1S/B2O3/c3-1-5-2-4. JKWMSGQKBLHBQQ-UHFFFAOYSA-N.
Candidalysin
Candidalysin is a cytolytic peptide toxin, which is initially isolated from Candida albicans and exhibits virulent and avirulent characters. Candidalysin activates epithelial cell signaling pathways by interacting with the epithelial growth factor receptor (EGFR) of host cells, activates matrix metalloproteinase ( MMP ) and calcium flux, resulting in inflammatory responses and recruitment of immune cells. Candidalysin exhibits cytotoxicity by dealing membran damage to host cells [1]. Uses: Scientific research. Group: Peptides. CAS No. 1906866-53-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10408.
CE3F4
CE3F4 is a noncompetitive Epac1 inhibitor that inhibits Epac-induced Rap activation and prevents isoprenaline-induced autophagy flux in cardiomyocytes. It has no effect on PKA activity in the presence of cAMP. Synonyms: CE3F4; CE-3-F-4; CE 3 F 4; CE-3F4; CE 3F4; 5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde. Grades: ≥98% by HPLC. CAS No. 143703-25-7. Molecular formula: C11H10Br2FNO. Mole weight: 351.01.
Celikalim
Celikalim is s ATP-sensitive potassium channel agonist originated by Wyeth. It increases K+ outward flux in dog and human airway smooth muscle. But clinical trials for Hypertension, Ischaemic heart disorders and Thrombosis was discontinued. Uses: Hypertension; ischaemic heart disorders; thrombosis. Synonyms: Way-120,491; Way120491; Way-120491; Way 120491; Celikalim;2-[(3S,4R)-3-hydroxy-2,2-dimethyl-6-(trifluoromethoxy)-3,4-dihydrochromen-4-yl]-3H-isoindol-1-one. Grades: 98%. CAS No. 124916-54-7. Molecular formula: C20H18F3NO4. Mole weight: 393.36.
Clarithromycin
Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4 -catalyzed triazolam alpha-hydroxylation with the IC 50 ( K i ) value of 56 (43) μM [2]. Clarithromycin significantly inhibits the HERG potassium current [3].Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 81103-11-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-17508.
Clarithromycin
Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM. Clarithromycin significantly inhibits the HERG potassium current.Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K. Group: Inhibitors. Alternative Names: Erythromycin, 6-O-methyl-. CAS No. 81103-11-9. Molecular formula: C38H69NO13. Mole weight: 747.95. Purity: 0.999. Catalog: ACM81103119-1.
Clarithromycin (Standard)
Clarithromycin (Standard) is the analytical standard of Clarithromycin. This product is intended for research and analytical applications. Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM [2]. Clarithromycin significantly inhibits the HERG potassium current [3].Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 81103-11-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-17508R.
DCAP
DCAP is a broad-spectrum antibiotic targeting the membranes of both Gram-positive and Gram-negative bacteria. DCAP blocks autophagy at the late stages by preventing autophagolysosome maturation and interrupting the autophagic flux [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 500015-20-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-136068.
Deoxyandrographolide
Deoxyandrographolide is a natural compound extracted from the herbs of Andrographis paniculata (Burm. f.) Nees. It could potently inhibit the growth of liver (HepG2 and SK-Hep1) and bile duct (HuCCA-1 and RMCCA-1) cancer cells. It controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. It was capable of preventing the development of fatty liver through AMPK-mediated regulation of lipid metabolism. It reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner in concentrations between 10-100 microM. It reduced PAF-induced calcium flux in the presence of extracellular calcium. It mediated activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism. Uses: Deoxyandrographolide could potently inhibit the growth of liver (hepg2 and sk-hep1) and bile duct (hucca-1 and rmcca-1) cancer cells. it controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. it reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner in concentrations between 10-100 microm. it reduced paf-induced calcium flux in the presence of extracellular calcium. Synonyms: 4-[2-[(4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-2,5,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalen-1-yl]ethyl]-2H-furan-5-one;2(5H)-Furanone, 3-[2-[(4aS,5R,6R,8aR)-3,4,4a,5,6,7,8,8a-octahydro-6-hydroxy-5-(hydroxymethyl)-2,5,8a-trimethyl-1-naphthalenyl]ethyl]-. Grades: >98%. CAS No. 79233-15-1. Molecular formula: C20H30O4. Mole weight: 334.45.
Diatomaceous Earth
Diatomaceous Earth. Synonyms: Diatomaceous earth, flux-calcined. CAS No. 68855-54-9. Pack Sizes: 1 kg, 5 kg. Product ID: CDC10-0011. Molecular formula: O2Si. Category: Cosmetic Chemical Abrasives. Product Keywords: Cosmetic Ingredients; Cosmetic Chemical Abrasives; Diatomaceous Earth; CDC10-0011; 68855-54-9; O2Si; Diatomaceous earth, flux-calcined; 272-489-0; MFCD00132803; 68855-54-9. EC Number: 272-489-0. Physical State: Powder. Quality Level: 100. Storage: Please store the product under the recommended conditions in the Certificate of Analysis. Boiling Point: N/A. Melting Point: >450°C. Density: 0.47 g/cm3 (loose weight)(lit.). Product Description: Diatomaceous earth is natural amorphous silica formed from the fossilized skeletons of diatoms. It has high water and oil absorption ability.
Diatomaceous Earth FW 12
Celatom FW-12 Diatomaceous Earth, also known as "DE" or "DE Powder," serves as a filter aid employed across various applications. Its primary application involves serving as a precoat in industrial wastewater filtration processes. This precoat enhances the concentration of solids within the sludge while simultaneously reducing the overall volume of sludge requiring disposal. Celatom FW-12 Diatomaceous Earth is a flux-calcined diatomaceous earth (DE) material, displaying a color spectrum from bright white to light pink. It exists as an odorless solid with a pH value of 10 in a 10% suspension. In terms of particle size, it exhibits a sieve analysis (Tyler) result of 3-15% retention at 150 Mesh (>105 microns), with less than 1% being soluble in water. Furthermore, its filter offers a permeability range of 650-1150 millidarcies. Uses: Filter Aid. Alternative Names: Diatomaceous Earth, Diatomaceous Earth Flux Calcined. Grades: Tech. CAS No. 68855-54-9, 14464-46-1. Pack Sizes: 50 lb.
USA
Diatomaceous Earth FW 14
Diatomaceous Earth FW 14 is a filter aid used in a variety of applications, such as swimming pools. When Diatomaceous Earth is introduced into the pool filter system, it coats the filter cloth. As water passes over the filter grids, the DE particles capture even the smallest suspended dirt particles. DE Powder also works wonders in wine making. The pores within and between the cell walls of Diatomaceous Earth are so small, they trap bacteria, clay particles, some viruses, and other suspended solids from liquids. This leaves the wine cleaner and with drastically reduced solids and contaminant levels. It is also used in wastewater as the primary use is as a precoat in the filtration of industrial wastewater. Uses: Filter Aid. Alternative Names: Diatomaceous Earth, Diatomaceous Earth Flux Calcined. Grades: Tech. CAS No. 68855-54-9, 14464-46-1. Pack Sizes: 50 lb.
USA
Disodium tetraborate
Sodium Tetraborate, is an important boron compound, which has a wide variety of applications. It is a component of many detergents, cosmetics, and enamel glazes. It is also used to make buffer solutions in biochemistry, as a fire retardant, as an anti-fungal compound for fiberglass, as a flux in metallurgy, neutron-capture shields for radioactive sources, a texturing agent in cooking, and as a precursor for other boron compounds. Group: Heterocyclic organic compound. Alternative Names: boricin;jaikin;borascu;sodium tetrabotare;BORAX. CAS No. 1330-43-4. Molecular formula: B4Na2O7. Appearance: White solid. Density: 2.367. ECNumber: 215-540-4. Catalog: ACM1330434.
Dizocilpine
Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a K d of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca 2+ flux [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-801. CAS No. 77086-21-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15084B.
EACC
EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 864941-31-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-129111.
Eldelumab
Eldelumab is a humanized anti-CXCL10 (IP-10) monoclonal antibody that binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab has been use for the treatment of ulcerative colitis. Synonyms: BMS-936557; MDX-1100. CAS No. 946414-98-8.
Enzyme for Cleaning apple or pear juice
Clean & maintain permeate flux-rate filter membranes. Applications: Apples & pears processing enzymes. Group: Enzymes. Synonyms: Cleaning apple or pear juice enzyme; Apples & Pears Processing Enzymes; Enzyme for Cleaning; Cleaning; apple; pear juice; Enzyme for Cleaning apple or pear juice enzyme; FJE-1421. Enzyme for apple or pear juice. Appearance: powder or liquid. Cleaning apple or pear juice enzyme; Apples & Pears Processing Enzymes; Enzyme for Cleaning; Cleaning; apple; pear juice; Enzyme for Cleaning apple or pear juice enzyme; FJE-1421. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form) or subject to client requirement. Cat No: FJE-1421.
FG 7142
FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor ( K i =91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit ( EC 50 = 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZK 39106; LSU-65. CAS No. 78538-74-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-100991.
Flunarizine-d8 Dihydrochloride
Flunarizine-d8 Dihydrochloride. Group: Biochemicals. Alternative Names: 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine-d8 Hydrochloride; Dinaplex-d8; Flugeral-d8; Flunagen-d8; Flunarl-d8; Fluxarten-d8; Gradient-d8; Issium-d8; Mondus-d8; R 14950-d8. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C26H20D8Cl2F2N2, Molecular Weight: 485.47. US Biological Life Sciences.
Worldwide
Flunarizine Dihydrochloride
Calcium channel blocker; fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral). Group: Biochemicals. Alternative Names: 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine Hydrochloride; Dinaplex; Flugeral; Flunagen; Flunarl; Fluxarten; Gradient; Issium; Mondus; R 14950. Grades: Highly Purified. CAS No. 30484-77-6. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Gold
insulated wire, 1m, conductor diameter 0.025mm, insulation thickness 0.002mm, PTFE (polytetrafluoroethylene) insulation, 99.99%. Uses: Gold based neutron flux monitors may use gold foils. au foils may be used to form a ausn/au joint system for opto-electronic chips. modified gold foil electrode may be used to study heterogeneous electron transfer properties of biological electron transfer proteins.3 electrodeposited polycrystalline palladium-nickel alloy on gold foils may be investigated for the enhanced catalytic behavior of the alloy. Group: Metal nano dispersion. Alternative Names: Gold Powder,Gold black,Gold element. CAS No. 7440-57-5. Product ID: gold. Molecular formula: 196.97. Mole weight: Au;Au. [Au].
Gold
insulated wire, 1m, conductor diameter 0.025mm, insulation thickness 0.002mm, PTFE (polytetrafluoroethylene) insulation, 99.99%. Uses: Gold based neutron flux monitors may use gold foils. au foils may be used to form a ausn/au joint system for opto-electronic chips. modified gold foil electrode may be used to study heterogeneous electron transfer properties of biological electron transfer proteins.3 electrodeposited polycrystalline palladium-nickel alloy on gold foils may be investigated for the enhanced catalytic behavior of the alloy. Group: Self assembly and lithographynanoparticlessubstrates and electrode materials vapor deposition precursors. Alternative Names: Gold Powder,Gold black,Gold element. CAS No. 7440-57-5. Pack Sizes: 1.5 g in rigid mailer. Product ID: gold. Molecular formula: 196.97. Mole weight: Au;Au. [Au]. 1S/Au. PCHJSUWPFVWCPO-UHFFFAOYSA-N.
Hydroxychloroquine
Hydroxychloroquine (HCQ) is a synthetic oral antimalarial drug that can be used in the study of malaria and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Hydroxychloroquine is a potent autophagic flux inhibitor with antiviral activity (such as SARS-CoV-2 virus) that inhibits Toll-like receptor 7/9 ( TLR7/9 ) signaling [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Signaling pathways. CAS No. 118-42-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-W031727.
Kb-r7943 mesylate
KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux. Group: Inhibitors. CAS No. 182004-65-5. Molecular formula: C16H17N3O3S.CH3SO3H. Mole weight: 427.5. Appearance: Solid. Purity: >99 %. Canonical SMILES: NC (SCCC1=CC=C (OCC2=CC=C ([N+] ([O-])=O)C=C2)C=C1)=N. CS (=O) (O)=O. Catalog: ACM182004655.
L-651,582
L-651,582 is a novel inhibitor of both cAMP-phosphodiesterases and GMP-phosphodiesterases. It is also an orally active calcium channel blocker. It prevents oxidative phosphorylation in cancer cells and exhibits inhibition of pro-inflammatory cytokines in tumor associated macrophages. It may be used as a potential anti-cancer drug. It ameliorates experimental colitis by inhibiting nuclear factor-κB activation, colonic fibrosis and cytokine production. It has antimetastatic, antiangiogenic and antiproliferative activity in vivo. It displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro. It blocks intracellular and mitochondrial calcium entry and flux, resulting in inhibition of calcium-release-activated calcium channel (CRAC) function, cell proliferation and maintenance of mitochondrial membrane potential. Synonyms: Carboxyamidotriazole; CAI; RFE-007; NSC-609974; L-651582; RFE007; NSC609974; L651582; 5-Amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide. Grades: ≥98% by HPLC. CAS No. 99519-84-3. Molecular formula: C17H12Cl3N5O2. Mole weight: 424.67.
Lasalocid sodium
Lasalocid sodium is a cationic ionophore antibiotic obtained from Streptomyces lasaliensis that, among other effects, dissociates the calcium fluxes in muscle fibers. It is used as a coccidiostat, especially in poultry. Synonyms: Lasalocid A Sodium Salt; Avatec; Bovatec. Grades: >95% by HPLC. CAS No. 25999-20-6. Molecular formula: C34H53NaO8. Mole weight: 612.77.
L-Asparagine monohydrate
Asparagine biosynthesis is catalyzed by glutamine-dependent asparagine synthetase in mammalian tissues. Elevated levels of free asparagine is observed in plants facing stress in the form of drought or high salt. It is also present in senescing leaves and germinating seeds. Uses: L-asparagine monohydrate has been used: as a component of sauton's and chelated sauton's media for mycobacterial growth to test its effect in the induction of ca2+ flux in rice roots using aequorin luminescence imaging as a component of fermentation medium for the blakeslea trispora spores. Group: Amino acids. Alternative Names: (S)-(+)-2-Aminosuccinamic acid, (S)-2-Aminosuccinic acid 4-amide, L-Aspartic acid 4-amide. CAS No. 5794-13-8. Molecular formula: NH2COCH2CH(NH2)COOH · H2O. Mole weight: 150.13. Canonical SMILES: [H]O[H].N[C@@H](CC(N)=O)C(O)=O. ECNumber: 200-735-9. Catalog: ACM5794138.
Levobupivacaine free base
Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by Abbott under the trade name Chirocaine. It acts via reversibly binding voltage-gated sodium channels to modulate ionic flux and block the initiation and transmission of nerve impulses. Uses: Local anaesthetic drug. Synonyms: (S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide; Levobupivacaine free base; (S)-1-Butyl-2',6'-pipecoloxylidide; L(-)-Bupivacaine. Grades: 98%. CAS No. 27262-47-1. Molecular formula: C18H28N2O. Mole weight: 288.44.
Lithium tetraborate
Metal & Ceramic Materials. Alternative Names: Boric acid dilithium salt. CAS No. 12007-60-2. Molecular formula: B4Li2O7. Mole weight: 169.2. Appearance: White flux. Purity: 99%+. IUPACName: Dilithium; [oxido(oxoboranyloxy)boranyl]oxy-oxoboranyloxyborinate. Canonical SMILES: [Li+]. [Li+]. B(=O)OB([O-])OB([O-])OB=O. Density: ≥0.25 g/mL at 25 °C (lit.). Catalog: ACM12007602.
Lumbokinase
Lumbokinase attenuates myocardial ischemia-reperfusion (I-R) injury through the activation of Sirt1 signaling, and thus enhances autophagic flux and reduces I-R-induced oxidative damage, inflammation and apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 556743-18-1. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-E70008.
Maduramicin ammonium
Maduramicin (Maduramycin) ammonium is isolated from the actinomycete Actinomadura rubra. Maduramicin ammonium is an oral active anticoccidial agent used in research related to Eimeria, Adenosarcina, Enterococcus faecalis, and Enterococcus disperitus infections. Maduramicin ammonium induces apoptosis ( apoptosis ) in chicken cardiomyocytes through both intrinsic and extrinsic pathways and also impairs autophagic flux and induces rhabdomyolysis by activating the AMPK -mediated eIF2α-ATF4 endoplasmic reticulum stress pathway [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Maduramycin ammonium. CAS No. 84878-61-5. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N7071A.
Mavorixafor free base
Mavorixafor, also known as AMD11070, AMD070, X4P-001, is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF-1α ligand binding (IC50 = 12.5 ± 1.3 nM), inhibits SDF-1 mediated calcium flux (IC50 = 9.0 ± 2.0 nM) and SDF-1α mediated activation of the CXCR4 receptor as measured by a Eu-GTP binding assay (IC50 =39.8 ± 2.5 nM) or a [(35)S]-GTPγS binding assay (IC50 =19.0 ± 4.1 nM), and inhibits SDF-1α stimulated chemotaxis (IC50 =19.0 ± 4.0 nM). AMD11070 abrogates melanoma cell migration and is significantly more effective than AMD3100. AMD11070 represents a novel therapeutic strategy for both B-RAF wild-type and mutated melanomas. Group: Antagonists. Alternative Names: AMD11070, AMD 11070, AMD-11070, AMD070, AMD 070, AMD-070, X4P-001, X49001, X4P 001, Mavorixafor. CAS No. 558447-26-0. Molecular formula: C21H27N5. Mole weight: 349.48. Appearance: Solid powder. Purity: >95%. IUPACName: (S)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine. Canonical SMILES: NCCCCN ([C@@H]1C2=NC=CC=C2CCC1)CC3=NC4=C (N3)C=CC=C4. Catalog: ACM558447260.
Methyl 2-oxo-1-pyrrolidineacetate
An impurity Piracetam which modulates Na+-flux at AMPA receptors. Synonyms: methyl 2-(2-oxopyrrolidin-1-yl)acetate. Grades: 98.5 %. CAS No. 59776-88-4. Molecular formula: C7H11NO3. Mole weight: 157.17.
MHY1485
mTOR activator with an inhibitory effect on autophagy. MHY1485 markedly increased the LC3II/LC3I ratio dose-dependently and time-dependently by inhibition of the fusion between autophagosomes and lysosomes, and without increasing the autophagic flux. At 2 μM, MHY1485 did not show any cell death during longer treatment, supporting that MHY1485 had less toxicity than other well-known inhibitors of autophagy. MHY1485 was also tested and found moderately active as antimalarial agent (MIC value of ca. 26 μM against P. Falciparum). Synonyms: MHY-1485; MHY1485; MHY 1485. Grades: >98%. CAS No. 326914-06-1. Molecular formula: C17H21N7O4. Mole weight: 387.39.
Phosphoenolpyruvate carboxylase is an enzyme in the family of carboxy-lyases found in plants and some bacteria that catalyzes the addition of bicarbonate (HCO3-) to phosphoenolpyruvate (PEP) to form the four-carbon compound oxaloacetate and inorganic phosphate: PEP + HCO3-? oxaloacetate + Pi. This reaction is used for carbon fixation in CAM (crassulacean acid metabolism) and C4 organisms, as well as to regulate flux through the citric acid cycle (also known as Krebs or TCA cycle) in bacteria and plants. The enzyme structure and its two step catalytic, irreversible mechanism have been well studied. PEP carboxylase is highly regulated, both by phosphorylation and allostery. Applications: This enzyme is useful for enzymatic determination of carbon dioxide when coupled with malate dehydrogenase in clinical analysis. Group: Enzymes. Synonyms: PEP carboxylase; PEPCase; PEPC; EC 4.1.1.31; Phosphoenolpyruvate carboxylase; PDB ID: 3ZGE. Enzyme Commission Number: EC 4.1.1.31. CAS No. 9067-77-0. PEPC. Mole weight: approx. 390 kDa (by gel filtration). Activity: Grade? 5.0U/mg-solid or more. Stability: Stable at-20°C for at least one year. Appearance: White amorphous powder, lyophilized. Source: Microorganism. PEP carboxylase; PEPCase; PEPC; EC 4.1.1.31; Phosphoenolpyruvate carboxylase; PDB ID: 3ZGE. Cat No: DIA-212.
NBI-42902
NBI-42902 is a potent inhibitor of peptide radioligand binding to the human GnRH receptor (K(I)=0.56 nm). Tritiated NBI-42902 binds with high affinity (K(d)=0.19 nm) to a single class of binding sites and can be displaced by a range of peptide and nonpeptide GnRH receptor ligands. In vitro experiments demonstrate that NBI-42902 is a potent functional, competitive antagonist of GnRH stimulated IP accumulation, Ca(2+) flux, and ERK1/2 activation. It did not stimulate histamine release from rat peritoneal mast cells. Finally, it is effective in lowering serum LH in castrated male macaques after oral administration. Overall, these data provide a benchmark of pharmacological characteristics required for a nonpeptide GnRH antagonist to effectively suppress gonadotropins in humans and suggest that NBI-42902 may have clinical utility as an oral agent for suppression of the hypothalamic-pituitary-gonadal axis. Synonyms: NBI 42902; NBI42902; (R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione. CAS No. 352290-60-9. Molecular formula: C27H24F3N3O3. Mole weight: 495.50.
PFK-158
PFK-158, also known as ACT-PFK-158, is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) and derivative of 3-(3-pyridinyl)-1-[4-pyridinyl]-2-propen-1-one (3PO), with potential antineoplastic activity. Upon administration, PFKFB3 inhibitor PFK-158 binds to and inhibits the activity of PFKFB3, which leads to the inhibition of both the glycolytic pathway in and glucose uptake by cancer cells. This prevents the production of macromolecules and energy that causes the enhanced cellular proliferation in cancer cells as compared to that of normal, healthy cells. Depriving cancer cells of nutrients and energy leads to the inhibition of cancer cell growth. PFKFB3, an enzyme that catalyzes the conversion of fructose-6-phosphate to fructose-2,6-bisphosphate, is highly expressed and active in human cancer cells; it plays a key role in increasing both glycolytic flux in and proliferation of cancer cells. Synonyms: PFK158; PFK 158; PFK158; ACTPFK158. Grades: >98%. CAS No. 1462249-75-7. Molecular formula: C18H11F3N2O. Mole weight: 328.29.
PHA-543613 Dihydrochloride
PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype α7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer?s disease. PHA-543613 is active in both in vitro (binding, calcium flux, patch-clamp) and in vivo (auditory gating, novel object recognition) assays. Group: Biochemicals. Alternative Names: N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide Dihydrochloride;PHA 543613E. Grades: Highly Purified. CAS No. 478148-58-2. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Phosphatidylethanolamine
Phosphatidylethanolamine is an orally active phospholipid widely present in organisms. Phosphatidylethanolamine participates in the formation of autophagosome membrane as a lipid anchor of autophagy-related protein Atg8/LC3. Phosphatidylethanolamine enhances Autophagic flux, promotes cell differentiation, regulates lipid droplet fusion, delays aging, and also affects lipid metabolism and membrane integrity [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 90989-93-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W250118.
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