Ghrelin Suppliers USA
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Product | Description | |
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Ghrelin-Cys(BMCC-biotinyl) (human) Quick inquiry Where to buy Suppliers range | Ghrelin-Cys(BMCC-biotinyl) (human) is used for ELISA development and receptor research. Synonyms: Ghrelin-Cys(1-biotinamido-4-(4'-maleimido-N-methyl-cyclohexyl)carboxamido)butane) (human); H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-Cys(BMCC-biotinyl)-OH. Grades: ≥95%. CAS No. 1927927-44-3. Molecular formula: C178H293N53O48S2. Mole weight: 4007.74. | |
Ghrelin (human) Quick inquiry Where to buy Suppliers range | Ghrelin (human) is an endogenous peptide agonist for the ghrelin receptor (GHS-R1a). Ghrelin stimulates release of growth hormone from the pituitary gland in vitro and in vivo, and regulates feeding, growth and energy production. CAS No. 258279-04-8. Molecular formula: C149H249N47O42. Mole weight: 3370.9. | |
Ghrelin(mouse,rat) Quick inquiry Where to buy Suppliers range | Ghrelin(mouse,rat). Group: Heterocyclic Organic Compound. Alternative Names: Ghrelin (mouse, rat);Ghrelin (rat). Grades: >95%. CAS No. 258338-12-4. Product ID: ACM258338124. Molecular formula: C147H245N45O42. Mole weight: 3314.79. | |
Ghrelin (rat) Quick inquiry Where to buy Suppliers range | Ghrelin (rat) is an endogenous peptide agonist for the ghrelin receptor (GHS-R1a). Ghrelin stimulates release of growth hormone from the pituitary gland in vitro and in vivo, and regulates feeding, growth and energy production. CAS No. 258338-12-4. Molecular formula: C147H245N45O42. Mole weight: 3314.83. | |
Ghrelin (rat) (acetyl) trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Ghrelin (rat) (acetyl) is a form of ghrelin that is acetylated at serine 3. Ghrelin is a circulating hormone and neuropeptide which binds to the growth hormone (GH) secretagogue receptor (GHS-R). Synonyms: glycyl-L-seryl-O-acetyl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-lysyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine, trifluoroacetate salt. Grades: ≥95%. Molecular formula: C141H233N45O42·xCF3COOH. Mole weight: 3230.64. | |
Ghrelin (rat) (palmitoyl) trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Ghrelin (rat) (palmitoyl) is a palmitoylated form of ghrelin which is a circulating hormone and neuropeptide binding to the growth hormone (GH) secretagogue receptor (GHS-R). Palmitoylated ghrelin is an agonist of GHS-R. Synonyms: glycyl-L-seryl-O-(1-oxohexadecyl)-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-lysyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine, trifluoroacetate salt. Grades: ≥95%. Molecular formula: C155H261N45O42·xCF3COOH. Mole weight: 3427.01. | |
Ghrelin (rat) trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Ghrelin is a circulating hormone and neuropeptide which binds to the growth hormone (GH) secretagogue receptor (GHS-R). Grades: ≥95%. Molecular formula: C147H245N45O42·xCF3COOH. Mole weight: 3314.80. | |
Ghrelin Receptor Antagonist, JMV 2959 Quick inquiry Where to buy Suppliers range | A 1, 2, 4-triazole derived compound that acts as a potent ghrelin receptor (GHS-R1a) antagonist (IC50 = 32nM in a binding assay, dissociation constant Kb = 19nM). Shown to reduce hexarelin-induced food intake [hexarelin (80ug/kg, cumulative food intake (g of food/100g of body weight) at 6h by acute administration (sc) of JMV 2959 (160ug/kg)] in rats without affecting the basal food intake. Also suppresses ghrelin and fasting-induced food intake at the level of the central nervous system. Reported to suppress genes up-regulated by ghrelin. Does not affect intracellular Ca2+ mobilization. Group: Biochemicals. Alternative Names: (R)-N-(2-(1H-indol-3-yl)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)ethyl)-2-aminoacetamide Hydrochloride, GHSR1a Antagonist, GH Secretagogue Receptor Antagonist, JMV2959, Growth Hormone Secretagogue Receptor Antagonist. Grades: Highly Purified. CAS No. 925238-89-7. Pack Sizes: 10mg. Molecular Formula: C??H??N?O, Molecular Weight: 254.29. US Biological Life Sciences. | Worldwide |
des-Gln14-Ghrelin (rat) Quick inquiry Where to buy Suppliers range | Des-Gln14-Ghrelin (rat) is an endogenous ligand for the ghrelin receptor (GHS-R1a), produced by alternative splicing of the rat ghrelin gene. It induces Ca2+ release in cells expressing ghrelin receptors (EC50 = 2.4 nM) and GH release in vivo. Synonyms: des-Gln14-Ghrelin (rat); des Gln14 Ghrelin (rat). CAS No. 293735-04-3. Molecular formula: C142H237N43O40. Mole weight: 3186.7. | |
(Des-octanoyl)-Ghrelin (human) Quick inquiry Where to buy Suppliers range | (Des-octanoyl)-Ghrelin (human). Uses: Peptide Inhibitors. CAS No. 313951-59-6. Product ID: PI-007. | |
[Des-octanoyl]-Ghrelin (human) Quick inquiry Where to buy Suppliers range | [Des-octanoyl]-Ghrelin (human) is the major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release. It exhibits negative inotropic effects in papillary muscle and cardioprotective activity. It also displays an inhibitory effect on cell proliferation in breast and prostate cancer cell lines. Synonyms: UNII-XEW3CUX2ZE; XEW3CUX2ZE. CAS No. 313951-59-6. Molecular formula: C141H235N47O41. Mole weight: 3244.51. | |
(Des-octanoyl)-Ghrelin (human) trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R). Synonyms: glycyl-L-seryl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-arginyl-L-valyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine trifluoroacetate salt. Grades: ≥95%. Molecular formula: C141H235N47O41·xCF3COOH. Mole weight: 3244.67. | |
[Des-octanoyl]-Ghrelin (rat) Quick inquiry Where to buy Suppliers range | [Des-octanoyl]-Ghrelin (rat) is the major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release. Synonyms: Des-acyl ghrelin (rat). CAS No. 307950-60-3. Molecular formula: C139H231N45O41. Mole weight: 3188.63. | |
[Des-octanoyl]-Ghrelin (rat) Quick inquiry Where to buy Suppliers range | [Des-octanoyl]-Ghrelin (rat). Uses: API. CAS No. 307950-60-3. Product ID: 10-101-320. | |
(Ser(Ac)3)-Ghrelin (mouse, rat) Quick inquiry Where to buy Suppliers range | Synonyms: H-Gly-Ser-Ser(Ac)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH; glycyl-L-seryl-O-acetyl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-lysyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-alpha-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine. Grades: ≥95%. CAS No. 321974-76-9. Molecular formula: C141H233N45O42. Mole weight: 3230.64. | |
1,2,4-Triazole Quick inquiry Where to buy Suppliers range | 1,2,4-Triazole is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959. Group: Biochemicals. Alternative Names: 1H-1,2,4-Triazole; s-Triazole; 3,4-Diazapyrrole; 4H-1,2,4-Triazole; NSC 8312. Grades: Highly Purified. CAS No. 288-88-0. Pack Sizes: 50g. US Biological Life Sciences. | Worldwide |
1,2,4-Triazole-1,2,4-15N3 Quick inquiry Where to buy Suppliers range | 1,2,4-Triazole-1,2,4-15N3 is the labeled analog of 1,2,4-Triazole (T767410), which is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959. Group: Biochemicals. Grades: Highly Purified. CAS No. 1173023-70-5. Pack Sizes: 1mg, 10mg. Molecular Formula: C2H315N3, Molecular Weight: 72.05. US Biological Life Sciences. | Worldwide |
13Z,16Z-Docosadienoic acid Quick inquiry Where to buy Suppliers range | 13Z,16Z-Docosadienoic acid is a natural ω-6 polyunsaturated fatty acid (PUFA). It is an agonist of free fatty acid receptor 4 (FFAR4, also known as GPR120) and strongly inhibits the secretion of ghrelin by isolated mouse gastric cells. Synonyms: cis-13,16-Docosadienoic acid; (13Z,16Z)-docosa-13,16-dienoic acid. Grades: ≥98%. CAS No. 17735-98-7. Molecular formula: C22H40O2. Mole weight: 336.6. | |
1H-1,2,4-Triazole-3,5-13C2 Quick inquiry Where to buy Suppliers range | 1H-1,2,4-Triazole-3,5-13C2 is the labeled analog of 1,2,4-Triazole (T767410), which is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959. Group: Biochemicals. Grades: Highly Purified. CAS No. 1773496-71-1. Pack Sizes: 5mg, 50mg. Molecular Formula: 13C2H3N3, Molecular Weight: 71.05. US Biological Life Sciences. | Worldwide |
1H-1,2,4-Triazole-3,5-13C2-1,2,4-15N3 Quick inquiry Where to buy Suppliers range | 1H-1,2,4-Triazole-3,5-13C2-1,2,4-15N3 is labelled 1,2,4-Triazole (T767410) which is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959. Group: Biochemicals. Grades: Highly Purified. CAS No. 1261170-82-4. Pack Sizes: 1mg, 10mg. Molecular Formula: 13C2H315N3, Molecular Weight: 74.03. US Biological Life Sciences. | Worldwide |
Anamorelin Quick inquiry Where to buy Suppliers range | Anamorelin, also known as RC-1291 or ONO-7643, is the orally bioavailable, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Synonyms: RC 1291; RC-1291; RC1291; ONO 7643; ONO-7643; ONO7643. CAS No. 249921-19-5. Molecular formula: C31H42N6O3. Mole weight: 546.7. | |
Anamorelin Dihydrochloride Quick inquiry Where to buy Suppliers range | Anamorelin is a novel non-peptidic ghrelin mimetic and growth hormone secratogogue. Group: Biochemicals. Grades: Highly Purified. CAS No. 1469995-93-4. Pack Sizes: 10mg, 25mg. Molecular Formula: C31H44Cl2N6O3. US Biological Life Sciences. | Worldwide |
Anamorelin Fumarate Quick inquiry Where to buy Suppliers range | Anamorelin hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite. Synonyms: RC-1291 Fumarate; ONO-7643 Fumarate; RC1291 Fumarate; ONO7643 Fumarate; RC 1291 Fumarate; ONO 7643 Fumarate. Grades: >98%. CAS No. 339539-92-3. Molecular formula: C35H46N6O7. Mole weight: 662.78. | |
Anamorelin HCl Quick inquiry Where to buy Suppliers range | Anamorelin, also known as RC-1291 or ONO-7643, is the orally bioavailable, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Uses: For research used only. Synonyms: RC 1291; RC1291; RC-1291; RC 1291 HCl; ONO-7643; ONO7643; ONO 7643; Anamorelin hydrochloride. Grades: 98%. CAS No. 861998-00-7. Molecular formula: C31H43ClN6O3. Mole weight: 583.174. | |
AZ-GHS-22 Quick inquiry Where to buy Suppliers range | AZ-GHS-22 is an orally-available Ghrelin receptor (GHS-R1a) inverse agonist (IC50 = 0.77 nM) with very low CNS exposure. Synonyms: AZ-GHS-22; AZ GHS-22; AZ-GHS 22; AZ GHS 22; AZGHS22; 2-chloro-N-[[6-[3-(4-methylpiperazin-1-yl)propylsulfonyl]-1,3-benzothiazol-2-yl]carbamoyl]-5-morpholin-4-ylbenzamide. Grades: 98%. CAS No. 1143020-91-0. Molecular formula: C27H33ClN6O5S2. Mole weight: 621.17. | |
AZP-531 Quick inquiry Where to buy Suppliers range | AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. Uses: Peptide Inhibitors. CAS No. 1088543-62-7. Product ID: R1230. | |
Cortistatin 14, human, rat Quick inquiry Where to buy Suppliers range | Cortistatin 14, human, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus. Uses: Peptide Inhibitors. CAS No. 193829-96-8. Product ID: R1300. | |
CpdD hydrochloride Quick inquiry Where to buy Suppliers range | CpdD hydrochloride is a selective ghrelin receptor (GhrR aka GHSR-1a) antagonist. Synonyms: N-[(1R)-1-[3-[(4-bromophenyl)methyl]-1,2,4-oxadiazol-5-yl]-3-phenylpropyl]-3-(diethylamino)propane-1-sulfonamide hydrochloride. Grades: 99%. Molecular formula: C25H33BrN4O3S.HCl. Mole weight: 585.98. | |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P Quick inquiry Where to buy Suppliers range | [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a broad spectrum neuropeptide inverse agonist and antagonist. It acts as a full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM) and antagonist at tachykinin, bradykinin, CCK and bombesin receptors. It induces apoptosis and inhibits cancer cell growth in vitro. Synonyms: 1-Arg-5-Phe-7,9-Trp-11-Leu-substance P; D-Arg(10)-D-Phe(5)-D-Trp(7,9)-Leu(11)-SP; substance P, phenylalanyl(5)-tryptophyl(7,9)-leucine(11)-. CAS No. 96736-12-8. Molecular formula: C79H109N19O12. Mole weight: 1516.85. | |
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate Quick inquiry Where to buy Suppliers range | [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate is a broad-spectrum neuropeptide inverse agonist and antagonist. It acts as a full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM) and antagonist at tachykinin, bradykinin, CCK, and bombesin receptors. It induces apoptosis and inhibits cancer cell growth in vitro. Synonyms: H-D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2.CH3CO2H; D-arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-L-leucinamide acetic acid; [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P acetate. Grades: ≥95%. CAS No. 2918771-49-8. Molecular formula: C81H113N19O14. Mole weight: 1576.91. | |
[D-Lys3]-GHRP-6 Quick inquiry Where to buy Suppliers range | [D-Lys3]-GHRP-6 is an antagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM), and a GHRP-6 antagonist. Synonyms: [D-Lys3]-Growth Hormone Releasing Peptide-6. CAS No. 136054-22-3. Molecular formula: C49H63N13O6. Mole weight: 930.12. | |
EM574 Quick inquiry Where to buy Suppliers range | Shows strong gastrointestinal motor stimulating (GMS) activity. Motilin receptor agonist. Stimulates smooth muscle cell contraction. Stimulates cholinergic neurons in a non-vagal pathway. Enhances gastrointestinal contractile activity and accelerates gastric emptying. Shows orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, ghrelin receptor). Group: Biochemicals. Grades: Highly Purified. CAS No. 110480-13-2. Pack Sizes: 250ug, 1mg. Molecular Formula: C39H69NO12. US Biological Life Sciences. | Worldwide |
Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Quick inquiry Where to buy Suppliers range | AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. Uses: Peptide Inhibitors. CAS No. 116783-35-8. Product ID: R1362. | |
GHRP-2 Quick inquiry Where to buy Suppliers range | Pralmorelin is an agonist of ghrelin/growth hormone secretagogue (GHS) receptor. It is marketed by Kaken Pharmaceutical in Japan in a single-dose formulation for the assessment of growth hormone deficiency (GHD). Synonyms: Pralmorelin; KP-102; KP 102; KP102; GHRP 2; Growth hormone-releasing peptide 2. CAS No. 158861-67-7. Molecular formula: C45H55N9O6. Mole weight: 817.97. | |
GSK894490A Quick inquiry Where to buy Suppliers range | GSK894490A is a non-peptide ghrelin receptor agonist. It crosses the blood/brain barrier and elicit pro-cognitive effects in recognition and spatial learning and memory tests. It may be used as a potential drug target for therapeutic approaches to treat diseases affecting cognition. Uses: Gsk894490a may be used as a potential drug target for therapeutic approaches to treat diseases affecting cognition. Synonyms: Benzenesulfonamide, N-(5-((3R,5S)-3,5-dimethyl-1-piperazinyl)-2-methoxyphenyl)-4-(5-methyl-2-furanyl)-, hydrochloride (1:1), rel-;N-[5-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl]-4-(5-methylfuran-2-yl)benzenesulfonamide hydrochloride;GSK-894490A. Grades: >98 %. CAS No. 1012035-06-1. Molecular formula: C24H30ClN3O4S. Mole weight: 492.03. | |
GSK 962040 Quick inquiry Where to buy Suppliers range | GSK 962040 is a selective motilin receptor agonist with pEC50 value of 7.9. It is effective as a stimulant of human and rabbit gastrointestinal motility. lt represents a new opportunity as a treatment in diabetic gastroparesis. It is discovered as a therapeutic agent for conditions associated with delayed gastric emptying. It is highly selective against motilin receptor over the human ghrelin receptor and hERG. It also has no significant activity against other receptors including 5-HT, adrenergic, dopamine, histamine and adenosine receptors. It is found to enhance the EFS-induced cholinergic contraction and cause a small muscle contraction at high concentration in rabbit isolated gastric antrum. It also induces the contraction of human-isolated stomach preparations at 10μM. It had no significant activity at a range of other receptors (including ghrelin), ion channels and enzymes in vitro. It was preferred because its initial IC50 values at CYP3A4 were significantly higher than our preferred threshold of 10 μM. It induced phasic contractions, the duration of which was dose-related. It strongly facilitated cholinergic activity in the antrum, with lower activity in fundus and small intestine only. It was developed by glaxosmithkline and has been in Cilinic Phase 2. Uses: Gsk 962040 may be used as a treatment in diabetic gastroparesis. Synonyms: GSK-962040; GSK 962040; GSK962040; Camicinal;1-[4-(3-fluoroanilino)piperidin-1-yl]-2-[4-[[(3S)-3-methylpiperazin-1-yl]methyl]phenyl]ethanone. Grades: >98%. CAS No. 923565-21-3. Molecular formula: C25H33FN4O. Mole weight: 424.55. | |
Ibutamoren Quick inquiry Where to buy Suppliers range | Ibutamoren, also known as MK-677 (L-163,191), is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels.It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity. Synonyms: L 163191; L-163191; L163191; MK-0677; MK0677; MK 0677; (R)-2-amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide. CAS No. 159634-47-6. Molecular formula: C27H36N4O5S. Mole weight: 528.67. | |
Ibutamoren Mesylate Quick inquiry Where to buy Suppliers range | Ibutamoren, also known as MK-677 or L-163,191, is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity. Synonyms: MK-677; MK 677; MK677; Crescendo; MK 0677; MK-0677; MK0677. Grades: >98%. CAS No. 159752-10-0. Molecular formula: C28H40N4O8S2. Mole weight: 624.77. | |
Ipamorelin Quick inquiry Where to buy Suppliers range | Ipamorelin is a ghrelin mimetic displaying growth hormone (GH) releasing activity. Ipamorelin binds to ghrelin receptor (or GH secretagogue receptor, GHSR) in the brain and promotes the GH release. It has been investigated for the treatment of ileus and gastrointestinal dysmotility. Synonyms: NNC-26-0161; NNC 26-0161; NNC26-0161; NNC-260161; NNC 260161; NNC260161. CAS No. 170851-70-4. Molecular formula: C38H49N9O5. Mole weight: 711.85. | |
Ipamorelin Quick inquiry Where to buy Suppliers range | Ipamorelin is a ghrelin mimetic displaying growth hormone (GH) releasing activity. Ipamorelin binds to ghrelin receptor (or GH secretagogue receptor, GHSR) in the brain and promotes the GH release. It has been investigated for the treatment of ileus and gastrointestinal dysmotility. Uses: API. CAS No. 170851-70-4. Product ID: HB00110. | |
K-(D-1-Nal)-FwLL-NH2 Quick inquiry Where to buy Suppliers range | K-(D-1-Nal)-FwLL-NH2 is a high affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively), which blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways. Uses: Peptide Inhibitors. CAS No. 1394288-22-2. Product ID: R0816. | |
K-(D-1-Nal)-FwLL-NH2 Quick inquiry Where to buy Suppliers range | K-(D-1-Nal)-FwLL-NH2 is a potent and high affinity inverse ghrelin receptor inverse agonist. Its Ki values are 31 and 4.9 nM in HEK293T and COS7 cells respectively. It blocks ghrelin receptor-mediated G13- and Gq-dependent signaling pathways. Synonyms: L-Lysyl-3-(1-naphthalenyl)-D-alanyl-L-phenylalanyl-D-tryptophyl-L-leucyl-L-leucinamide; K-(D-1-Nal)-FwLL-NH2; K (D 1 Nal) FwLL NH2. Grades: >98%. CAS No. 1394288-22-2. Molecular formula: C51H67N9O6. Mole weight: 902.13. | |
L-692,585 Quick inquiry Where to buy Suppliers range | L-692,585 is a non-peptide, highly potent and selective ghrelin receptor (GHS-R1a) agonist with Ki value of 0.8 nM. It shows GH-secretory activity in several species including human. It increases plasma GH levels in vivo and is 2-2.5-fold more potent than GHRP-6. Synonyms: 3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide; [R-(R*,R*)]-3-[(2-hydroxypropyl)amino]-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide; 1H-1-Benzazepine, Butanamide derivative; L 692585; L692585; L-692585. Grades: ≥98% by HPLC. CAS No. 145455-35-2. Molecular formula: C32H37N7O3. Mole weight: 567.69. | |
Macimorelin Quick inquiry Where to buy Suppliers range | Macimorelin (also known as AEZS-130, EP-1572) is a novel synthetic small molecule, acting as a ghrelin agonist, that is orally active and stimulates the secretion of growth hormone (GH). Based on results of Phase 1 studies, AEZS-130 has potential applications for the treatment of cachexia, a condition frequently associated with severe chronic diseases. In addition to the therapeutic application, a Phase 3 trial with AEZS-130 as a diagnostic test for growth hormone deficiencies in adults has been completed. Synonyms: AEZS-130; AEZS 130; AEZS130; EP-1572; EP1572; EP 1572; JMV 1843; JMV-1843; 2-amino-N-((R)-1-(((R)-1-formamido-2-(1H-indol-3-yl)ethyl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-methylpropanamide. Grades: 98%. CAS No. 381231-18-1. Molecular formula: C26H30N6O3. Mole weight: 474.56. | |
Obestatin (human) Quick inquiry Where to buy Suppliers range | Obestatin is a 23 amino acid peptide hormone which is formed by cleavage of the ghrelin and obestatin prepropeptide. It can suppress food intake and reduce body weight-gain in rats. Synonyms: C16102; Obestatin. Grades: ≥95% by HPLC. CAS No. 1081110-72-6. Molecular formula: C116H176N32O33. Mole weight: 2546.86. | |
Obestatin (rat) Quick inquiry Where to buy Suppliers range | Obestatin is a 23 amino acid bioactive peptide that encoded by the ghrelin gene. It can suppress food intake and reduce body weight-gain in rats. Synonyms: H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2; L-phenylalanyl-L-asparagyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alpha-aspartyl-L-valyl-glycyl-L-isoleucyl-L-lysyl-L-leucyl-L-seryl-glycyl-L-alanyl-L-glutaminyl-L-tyrosyl-L-glutaminyl-L-glutaminyl-L-histidyl-glycyl-L-arginyl-L-alanyl-L-leucinamide; Obestatin (mouse, rat). Grades: ≥95% by HPLC. CAS No. 869705-22-6. Molecular formula: C114H174N34O31. Mole weight: 2516.84. | |
PF 04628935 Quick inquiry Where to buy Suppliers range | PF 04628935 is a potent antagonist/inverse agonist of the ghrelin receptor, growth hormone secretagogue receptor 1a (GHS-R1a) with an IC50 of 4.6 nM. It is orally bioavailable and exhibits reasonable brain penetration. Synonyms: 1-[2-[[2-Chloro-4-(2H-1,2,3-triazol-2-yl)phenyl]methyl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)ethanone; PF-04628935; PF04628935; PF 04628935; PF-4628935; PF4628935; PF 4628935. Grades: ≥98% by HPLC. CAS No. 1383719-97-8. Molecular formula: C24H26ClN7OS. Mole weight: 496.03. | |
Relamorelin Quick inquiry Where to buy Suppliers range | Relamorelin is a synthetic, centrally penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR). It is potentially useful for the treatment of diabetic gastroparesis, chronic idiopathic constipation, and anorexia nervosa. It is a pentapeptide and an analogue of ghrelin. It produces increases in plasma growth hormone, prolactin, and cortisol levels, and increases appetite in humans. It is under development by Rhythm Pharmaceuticals and is in phase II clinical trials. Uses: Relamorelin is potentially useful for the treatment of diabetic gastroparesis, chronic idiopathic constipation, and anorexia nervosa. Synonyms: BIM28131; BIM 28131; BIM-28131; BIM-28163; BIM 28163; BIM28163; RM131; RM-131; RM 131; Relamorelin;N-((R)-3-(benzo[b]thiophen-3-yl)-1-(((R)-1-(((S)-1-((4-carbamoylpiperidin-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)piperidine-3-carboxamide;4. Grades: 98%. CAS No. 661472-41-9. Molecular formula: C43H50N8O5S. Mole weight: 790.98. | |
Tabimorelin Hemifumarate Quick inquiry Where to buy Suppliers range | The hemifumarete salt form of tabimorelin, which is found to be an agonist of ghrelin receptor (GHS-R1a) so that could be used in the treatment of growth hormone deficit. Synonyms: Tabimorelin Hemifumarate; N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-Dimethyl-D-phenylalaninamide Hemifumarate; NN 703 Hemifumarate; NNC 26-0703 Hemifumarate. Grades: > 95%. CAS No. 242143-80-2. Molecular formula: C32H40N4O3.1/2C4H4O4. Mole weight: 586.73. | |
Tacalcitol Impurity 1 Quick inquiry Where to buy Suppliers range | One of the impurities of Tacalcitol, which is a ghrelin receptor agonist and could be used against growth hormone deficit. Synonyms: 1,?3-Cyclohexanediol, 4-methylene-5-[(2E)?-2-[(1R,?3aS,?7aR)?-octahydro-1-[(1R,?4S)?-4-hydroxy-1,?5-dimethylhexyl]?-7a-methyl-4H-inden-4-ylidene]?ethylidene]?-, (1R,?3S,?5Z)?-. Grades: > 95%. CAS No. 57333-95-6. Molecular formula: C27H44O3. Mole weight: 416.65. | |
TC-G-1008 Quick inquiry Where to buy Suppliers range | TC-G-1008, also known as GPR39-C3, is a potent and orally available GPR39 agonist (EC50= 0.4 and 0.8 nM for rat and human receptors respectively) with great selectivity for GPR39 over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Synonyms: GPR39-C3, GPR39C3, GPR39 C3, TC-G-1008, TC-G1008, TC-G 1008, TCG-1008, TCG1008, TCG 1008; N- [3-chloro-4- [ [ [2- (methylamino) -6-pyridin-2-ylpyrimidin-4-yl] amino] methyl] phenyl] methanesulfonamide; GPR39-C3; N- (3-chloro-4- ( ( (2- (methylamino) -6- (2-pyridinyl) -4-pyrimidinyl) amino) methyl) phenyl) methanesulfonamide; TC-G 1008. CAS No. 1621175-65-2. Molecular formula: C18H19ClN6O2S. Mole weight: 418.9. | |
TM N1324 Quick inquiry Where to buy Suppliers range | TM N1324 is an orally bioavailable, potent and selective GPR39 agonist. It inhibits the release of ghrelin and somatostatin from primary gastric mucosa cells in vitro. Synonyms: 4-(2-Chloro-4-fluorophenyl)-1,4,5,7-tetrahydro-3-methyl-1-(9H-purin-6-yl)-6H-pyrazolo[3,4-b]pyridin-6-one. Grades: ≥98% by HPLC. CAS No. 1144477-35-9. Molecular formula: C18H13ClFN7O. Mole weight: 397.79. | |
YIL 781 Quick inquiry Where to buy Suppliers range | YIL 781 is a ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM) with no significant affinity for the motilin receptor (Ki = 6 μM). YIL 781 inhibits ghrelin to reduce insulin secretion both in vivo and in vitro. YIL 781 may be beneficial for the treatment of obesity and diabetes. Uses: Potential treatment of obesity and diabetes. Synonyms: YIL 781; YIL781; YIL-781; 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone; KB-276128; KB 276128; KB276128. Grades: ≥98% by HPLC. CAS No. 875258-85-8. Molecular formula: C24H28FN3O2. Mole weight: 409.51. | |
YIL 781, Hydrochloride Salt Quick inquiry Where to buy Suppliers range | Ghrelin receptor antagonist (GHS-R1a) (Ki = 17nM). Displays no significant affinity for the motilin receptor (Ki = 6uM). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro. Improves glucose homeostasis in vivo. Group: Biochemicals. Alternative Names: 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone. Grades: Highly Purified. CAS No. 875258-85-8. Pack Sizes: 5mg. Molecular Formula: C??H??FN?O?.HCl, Molecular Weight: 445.96. US Biological Life Sciences. | Worldwide |