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| Product | Description | |
|---|---|---|
| Ghrelin-Cys(BMCC-biotinyl) (human) | Ghrelin-Cys(BMCC-biotinyl) (human) is used for ELISA development and receptor research. Synonyms: Ghrelin-Cys(1-biotinamido-4-(4'-maleimido-N-methyl-cyclohexyl)carboxamido)butane) (human); H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-Cys(BMCC-biotinyl)-OH. Grades: ≥95%. CAS No. 1927927-44-3. Molecular formula: C178H293N53O48S2. Mole weight: 4007.74. |  |
| Ghrelin (human) | Ghrelin (human) is an endogenous peptide agonist for the ghrelin receptor (GHS-R1a). Ghrelin stimulates release of growth hormone from the pituitary gland in vitro and in vivo, and regulates feeding, growth and energy production. CAS No. 258279-04-8. Molecular formula: C149H249N47O42. Mole weight: 3370.9. | |
| Ghrelin (rat) | Ghrelin (rat) is an endogenous peptide agonist for the ghrelin receptor (GHS-R1a). Ghrelin stimulates release of growth hormone from the pituitary gland in vitro and in vivo, and regulates feeding, growth and energy production. CAS No. 258338-12-4. Molecular formula: C147H245N45O42. Mole weight: 3314.83. | |
| Ghrelin (rat) (acetyl) trifluoroacetate salt | Ghrelin (rat) (acetyl) is a form of ghrelin that is acetylated at serine 3. Ghrelin is a circulating hormone and neuropeptide which binds to the growth hormone (GH) secretagogue receptor (GHS-R). Synonyms: glycyl-L-seryl-O-acetyl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-lysyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine, trifluoroacetate salt. Grades: ≥95%. Molecular formula: C141H233N45O42·xCF3COOH. Mole weight: 3230.64. | |
| Ghrelin (rat) (palmitoyl) trifluoroacetate salt | Ghrelin (rat) (palmitoyl) is a palmitoylated form of ghrelin which is a circulating hormone and neuropeptide binding to the growth hormone (GH) secretagogue receptor (GHS-R). Palmitoylated ghrelin is an agonist of GHS-R. Synonyms: glycyl-L-seryl-O-(1-oxohexadecyl)-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-lysyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine, trifluoroacetate salt. Grades: ≥95%. Molecular formula: C155H261N45O42·xCF3COOH. Mole weight: 3427.01. | |
| Ghrelin (rat) trifluoroacetate salt | Ghrelin is a circulating hormone and neuropeptide which binds to the growth hormone (GH) secretagogue receptor (GHS-R). Grades: ≥95%. Molecular formula: C147H245N45O42·xCF3COOH. Mole weight: 3314.80. | |
| Ghrelin Receptor Antagonist, JMV 2959 | A 1, 2, 4-triazole derived compound that acts as a potent ghrelin receptor (GHS-R1a) antagonist (IC50 = 32nM in a binding assay, dissociation constant Kb = 19nM). Shown to reduce hexarelin-induced food intake [hexarelin (80ug/kg, cumulative food intake (g of food/100g of body weight) at 6h by acute administration (sc) of JMV 2959 (160ug/kg)] in rats without affecting the basal food intake. Also suppresses ghrelin and fasting-induced food intake at the level of the central nervous system. Reported to suppress genes up-regulated by ghrelin. Does not affect intracellular Ca2+ mobilization. Group: Biochemicals. Alternative Names: (R)-N-(2-(1H-indol-3-yl)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)ethyl)-2-aminoacetamide Hydrochloride, GHSR1a Antagonist, GH Secretagogue Receptor Antagonist, JMV2959, Growth Hormone Secretagogue Receptor Antagonist. Grades: Highly Purified. CAS No. 925238-89-7. Pack Sizes: 10mg. Molecular Formula: C??H??N?O, Molecular Weight: 254.29. US Biological Life Sciences. |  Worldwide |
| des-Gln14-Ghrelin (rat) | Des-Gln14-Ghrelin (rat) is an endogenous ligand for the ghrelin receptor (GHS-R1a), produced by alternative splicing of the rat ghrelin gene. It induces Ca2+ release in cells expressing ghrelin receptors (EC50 = 2.4 nM) and GH release in vivo. Synonyms: des-Gln14-Ghrelin (rat); des Gln14 Ghrelin (rat). CAS No. 293735-04-3. Molecular formula: C142H237N43O40. Mole weight: 3186.7. | |
| [Des-octanoyl]-Ghrelin (human) | [Des-octanoyl]-Ghrelin (human) is the major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release. It exhibits negative inotropic effects in papillary muscle and cardioprotective activity. It also displays an inhibitory effect on cell proliferation in breast and prostate cancer cell lines. Synonyms: UNII-XEW3CUX2ZE; XEW3CUX2ZE. CAS No. 313951-59-6. Molecular formula: C141H235N47O41. Mole weight: 3244.51. | |
| (Des-octanoyl)-Ghrelin (human) trifluoroacetate salt | Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R). Synonyms: glycyl-L-seryl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-arginyl-L-valyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine trifluoroacetate salt. Grades: ≥95%. Molecular formula: C141H235N47O41·xCF3COOH. Mole weight: 3244.67. | |
| [Des-octanoyl]-Ghrelin (rat) | [Des-octanoyl]-Ghrelin (rat) is the major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release. Synonyms: Des-acyl ghrelin (rat). CAS No. 307950-60-3. Molecular formula: C139H231N45O41. Mole weight: 3188.63. | |
| (Ser(Ac)3)-Ghrelin (mouse, rat) | Synonyms: H-Gly-Ser-Ser(Ac)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH; glycyl-L-seryl-O-acetyl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-lysyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-alpha-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine. Grades: ≥95%. CAS No. 321974-76-9. Molecular formula: C141H233N45O42. Mole weight: 3230.64. | |
| 1,2,4-Triazole | 1,2,4-Triazole is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959. Group: Biochemicals. Alternative Names: 1H-1,2,4-Triazole; s-Triazole; 3,4-Diazapyrrole; 4H-1,2,4-Triazole; NSC 8312. Grades: Highly Purified. CAS No. 288-88-0. Pack Sizes: 50g. US Biological Life Sciences. | Worldwide |
| 1,2,4-Triazole-1,2,4-15N3 | 1,2,4-Triazole-1,2,4-15N3 is the labeled analog of 1,2,4-Triazole (T767410), which is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959. Group: Biochemicals. Grades: Highly Purified. CAS No. 1173023-70-5. Pack Sizes: 1mg, 10mg. Molecular Formula: C2H315N3, Molecular Weight: 72.05. US Biological Life Sciences. | Worldwide |
| 13Z,16Z-Docosadienoic acid | 13Z,16Z-Docosadienoic acid is a natural ω-6 polyunsaturated fatty acid (PUFA). It is an agonist of free fatty acid receptor 4 (FFAR4, also known as GPR120) and strongly inhibits the secretion of ghrelin by isolated mouse gastric cells. Synonyms: cis-13,16-Docosadienoic acid; (13Z,16Z)-docosa-13,16-dienoic acid. Grades: ≥98%. CAS No. 17735-98-7. Molecular formula: C22H40O2. Mole weight: 336.6. | |
| 1H-1,2,4-Triazole-3,5-13C2 | 1H-1,2,4-Triazole-3,5-13C2 is the labeled analog of 1,2,4-Triazole (T767410), which is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959. Group: Biochemicals. Grades: Highly Purified. CAS No. 1773496-71-1. Pack Sizes: 5mg, 50mg. Molecular Formula: 13C2H3N3, Molecular Weight: 71.05. US Biological Life Sciences. | Worldwide |
| 1H-1,2,4-Triazole-3,5-13C2-1,2,4-15N3 | 1H-1,2,4-Triazole-3,5-13C2-1,2,4-15N3 is labelled 1,2,4-Triazole (T767410) which is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959. Group: Biochemicals. Grades: Highly Purified. CAS No. 1261170-82-4. Pack Sizes: 1mg, 10mg. Molecular Formula: 13C2H315N3, Molecular Weight: 74.03. US Biological Life Sciences. | Worldwide |
| Anamorelin | Anamorelin, also known as RC-1291 or ONO-7643, is the orally bioavailable, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Synonyms: RC 1291; RC-1291; RC1291; ONO 7643; ONO-7643; ONO7643. CAS No. 249921-19-5. Molecular formula: C31H42N6O3. Mole weight: 546.7. | |
| Anamorelin | Anamorelin (RC-1291) is a potent ghrelin receptor agonist with EC 50 value of 0.74 nM in the FLIPR assay. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RC-1291; ONO-7643. CAS No. 249921-19-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-14734. |  |
| Anamorelin Dihydrochloride | Anamorelin is a novel non-peptidic ghrelin mimetic and growth hormone secratogogue. Group: Biochemicals. Grades: Highly Purified. CAS No. 1469995-93-4. Pack Sizes: 10mg, 25mg. Molecular Formula: C31H44Cl2N6O3. US Biological Life Sciences. | Worldwide |
| Anamorelin Fumarate | Anamorelin hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite. Synonyms: RC-1291 Fumarate; ONO-7643 Fumarate; RC1291 Fumarate; ONO7643 Fumarate; RC 1291 Fumarate; ONO 7643 Fumarate. Grades: >98%. CAS No. 339539-92-3. Molecular formula: C35H46N6O7. Mole weight: 662.78. | |
| Anamorelin HCl | Anamorelin, also known as RC-1291 or ONO-7643, is the orally bioavailable, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Uses: For research used only. Synonyms: RC 1291; RC1291; RC-1291; RC 1291 HCl; ONO-7643; ONO7643; ONO 7643; Anamorelin hydrochloride. Grades: 98%. CAS No. 861998-00-7. Molecular formula: C31H43ClN6O3. Mole weight: 583.174. | |
| Anamorelin hydrochloride | Anamorelin (RC-1291) hydrochloride is a potent ghrelin receptor agonist with EC 50 value of 0.74 nM in the FLIPR assay. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RC-1291 hydrochloride; ONO-7643 hydrochloride. CAS No. 861998-00-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14734A. | |
| AZ-GHS-22 | AZ-GHS-22 is an orally-available Ghrelin receptor (GHS-R1a) inverse agonist (IC50 = 0.77 nM) with very low CNS exposure. Synonyms: AZ-GHS-22; AZ GHS-22; AZ-GHS 22; AZ GHS 22; AZGHS22; 2-chloro-N-[[6-[3-(4-methylpiperazin-1-yl)propylsulfonyl]-1,3-benzothiazol-2-yl]carbamoyl]-5-morpholin-4-ylbenzamide. Grades: 98%. CAS No. 1143020-91-0. Molecular formula: C27H33ClN6O5S2. Mole weight: 621.17. | |
| Capromorelin tartrate | Capromorelin, also known as CP-424,391, is a growth hormone secretagogue and ghrelin mimetic ( hGHS-R1a K(I)=7 nM, rat pituicyte EC(50)=3 nM). Initial studies have shown the drug to directly raise insulin growth factor 1 (IGF-1) and growth hormone levels. Capromorelin showed enhanced intestinal absorption in rodent models and exhibited superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. This short-duration GHS was orally active in canine models and was selected as a development candidate for the treatment of musculoskeletal frailty in elderly adults. Group: Others. Alternative Names: CP-424,391; CP 424,391; CP424,391; CP-424391; CP 424391; CP424391; CP-424,391-18; Capromorelin tartrate. CAS No. 193273-69-7. Molecular formula: C32H41N5O10. Mole weight: 655.71. Appearance: Solid powder. Purity: >98%. IUPACName: 2-amino-N-((R)-1-((R)-3a-benzyl-2-methyl-3-oxo-2,3,3a,4,6,7-hexahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-3-(benzyloxy)-1-oxopropan-2-yl)-2-methylpropanamide (2R,3R)-2,3-dihydroxysuccinate. Canonical SMILES: CC (C) (N)C (N[C@@H] (C (N (C[C@]12CC3=CC=CC=C3)CCC1=NN (C)C2=O)=O)COCC4=CC=CC=C4)=O. O[C@H] ([C@H] (C (O)=O)O)C (O)=O. Catalog: ACM193273697. |  |
| CpdD hydrochloride | CpdD hydrochloride is a selective ghrelin receptor (GhrR aka GHSR-1a) antagonist. Synonyms: N-[(1R)-1-[3-[(4-bromophenyl)methyl]-1,2,4-oxadiazol-5-yl]-3-phenylpropyl]-3-(diethylamino)propane-1-sulfonamide hydrochloride. Grades: 99%. Molecular formula: C25H33BrN4O3S.HCl. Mole weight: 585.98. | |
| [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P | [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a broad spectrum neuropeptide inverse agonist and antagonist. It acts as a full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM) and antagonist at tachykinin, bradykinin, CCK and bombesin receptors. It induces apoptosis and inhibits cancer cell growth in vitro. Synonyms: 1-Arg-5-Phe-7,9-Trp-11-Leu-substance P; D-Arg(10)-D-Phe(5)-D-Trp(7,9)-Leu(11)-SP; substance P, phenylalanyl(5)-tryptophyl(7,9)-leucine(11)-. CAS No. 96736-12-8. Molecular formula: C79H109N19O12. Mole weight: 1516.85. | |
| [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate | [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate is a broad-spectrum neuropeptide inverse agonist and antagonist. It acts as a full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM) and antagonist at tachykinin, bradykinin, CCK, and bombesin receptors. It induces apoptosis and inhibits cancer cell growth in vitro. Synonyms: H-D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2.CH3CO2H; D-arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-L-leucinamide acetic acid; [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P acetate. Grades: ≥95%. CAS No. 2918771-49-8. Molecular formula: C81H113N19O14. Mole weight: 1576.91. | |
| [D-Lys3]-GHRP-6 | [D-Lys3]-GHRP-6 is an antagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM), and a GHRP-6 antagonist. Synonyms: [D-Lys3]-Growth Hormone Releasing Peptide-6. CAS No. 136054-22-3. Molecular formula: C49H63N13O6. Mole weight: 930.12. | |
| EM574 | Shows strong gastrointestinal motor stimulating (GMS) activity. Motilin receptor agonist. Stimulates smooth muscle cell contraction. Stimulates cholinergic neurons in a non-vagal pathway. Enhances gastrointestinal contractile activity and accelerates gastric emptying. Shows orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, ghrelin receptor). Group: Biochemicals. Grades: Highly Purified. CAS No. 110480-13-2. Pack Sizes: 250ug, 1mg. Molecular Formula: C39H69NO12. US Biological Life Sciences. | Worldwide |
| Fmoc-Thr[GalNAc(Ac)3-α-D]-OH | AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. Uses: Scientific research. Group: Peptides. Alternative Names: Fmoc-Thr(Ac3AcNH-α-Gal)-OH. CAS No. 116783-35-8. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-P0232. | |
| GHRP-2 | Pralmorelin is an agonist of ghrelin/growth hormone secretagogue (GHS) receptor. It is marketed by Kaken Pharmaceutical in Japan in a single-dose formulation for the assessment of growth hormone deficiency (GHD). Synonyms: Pralmorelin; KP-102; KP 102; KP102; GHRP 2; Growth hormone-releasing peptide 2. CAS No. 158861-67-7. Molecular formula: C45H55N9O6. Mole weight: 817.97. | |
| GSK894490A | GSK894490A is a non-peptide ghrelin receptor agonist. It crosses the blood/brain barrier and elicit pro-cognitive effects in recognition and spatial learning and memory tests. It may be used as a potential drug target for therapeutic approaches to treat diseases affecting cognition. Uses: Gsk894490a may be used as a potential drug target for therapeutic approaches to treat diseases affecting cognition. Synonyms: Benzenesulfonamide, N-(5-((3R,5S)-3,5-dimethyl-1-piperazinyl)-2-methoxyphenyl)-4-(5-methyl-2-furanyl)-, hydrochloride (1:1), rel-;N-[5-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl]-4-(5-methylfuran-2-yl)benzenesulfonamide hydrochloride;GSK-894490A. Grades: >98 %. CAS No. 1012035-06-1. Molecular formula: C24H30ClN3O4S. Mole weight: 492.03. | |
| GSK 962040 | GSK 962040 is a selective motilin receptor agonist with pEC50 value of 7.9. It is effective as a stimulant of human and rabbit gastrointestinal motility. lt represents a new opportunity as a treatment in diabetic gastroparesis. It is discovered as a therapeutic agent for conditions associated with delayed gastric emptying. It is highly selective against motilin receptor over the human ghrelin receptor and hERG. It also has no significant activity against other receptors including 5-HT, adrenergic, dopamine, histamine and adenosine receptors. It is found to enhance the EFS-induced cholinergic contraction and cause a small muscle contraction at high concentration in rabbit isolated gastric antrum. It also induces the contraction of human-isolated stomach preparations at 10μM. It had no significant activity at a range of other receptors (including ghrelin), ion channels and enzymes in vitro. It was preferred because its initial IC50 values at CYP3A4 were significantly higher than our preferred threshold of 10 μM. It induced phasic contractions, the duration of which was dose-related. It strongly facilitated cholinergic activity in the antrum, with lower activity in fundus and small intestine only. It was developed by glaxosmithkline and has been in Cilinic Phase 2. Uses: Gsk 962040 may be used as a treatment in diabetic gastroparesis. Synonyms: GSK-962040; GSK 962040; GSK962040; Camicinal;1-[4-(3-fluoroanilino)piperidin-1-yl]-2-[4-[[(3S)-3-methylpiperazin-1-yl]methyl]phenyl]ethanone. Grades: >98%. CAS No. 923565-21-3. Molecular formula: C25H33FN4O. Mole weight: 424.55. | |
| Ibutamoren | Ibutamoren, also known as MK-677 (L-163,191), is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels.It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity. Synonyms: L 163191; L-163191; L163191; MK-0677; MK0677; MK 0677; (R)-2-amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide. CAS No. 159634-47-6. Molecular formula: C27H36N4O5S. Mole weight: 528.67. | |
| Ibutamoren Mesylate | Ibutamoren, also known as MK-677 or L-163,191, is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity. Synonyms: MK-677; MK 677; MK677; Crescendo; MK 0677; MK-0677; MK0677. Grades: >98%. CAS No. 159752-10-0. Molecular formula: C28H40N4O8S2. Mole weight: 624.77. | |
| Ipamorelin | Ipamorelin is a ghrelin mimetic displaying growth hormone (GH) releasing activity. Ipamorelin binds to ghrelin receptor (or GH secretagogue receptor, GHSR) in the brain and promotes the GH release. It has been investigated for the treatment of ileus and gastrointestinal dysmotility. Synonyms: NNC-26-0161; NNC 26-0161; NNC26-0161; NNC-260161; NNC 260161; NNC260161. CAS No. 170851-70-4. Molecular formula: C38H49N9O5. Mole weight: 711.85. | |
| K-(D-1-Nal)-FwLL-NH2 | K-(D-1-Nal)-FwLL-NH2 is a potent and high affinity inverse ghrelin receptor inverse agonist. Its Ki values are 31 and 4.9 nM in HEK293T and COS7 cells respectively. It blocks ghrelin receptor-mediated G13- and Gq-dependent signaling pathways. Synonyms: L-Lysyl-3-(1-naphthalenyl)-D-alanyl-L-phenylalanyl-D-tryptophyl-L-leucyl-L-leucinamide; K-(D-1-Nal)-FwLL-NH2; K (D 1 Nal) FwLL NH2. Grades: >98%. CAS No. 1394288-22-2. Molecular formula: C51H67N9O6. Mole weight: 902.13. | |
| L-692,585 | L-692,585 is a non-peptide, highly potent and selective ghrelin receptor (GHS-R1a) agonist with Ki value of 0.8 nM. It shows GH-secretory activity in several species including human. It increases plasma GH levels in vivo and is 2-2.5-fold more potent than GHRP-6. Synonyms: 3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide; [R-(R*,R*)]-3-[(2-hydroxypropyl)amino]-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide; 1H-1-Benzazepine, Butanamide derivative; L 692585; L692585; L-692585. Grades: ≥98% by HPLC. CAS No. 145455-35-2. Molecular formula: C32H37N7O3. Mole weight: 567.69. | |
| L-Cysteine | L-Cysteine (Cysteine) is an orally active conditionally essential amino acid with hypoglycemic effects, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans. L-Cysteine can be used as an anorectic agent [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Cysteine. CAS No. 52-90-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-Y0337. | |
| L-Cysteine-15N | L-Cysteine- 15 N is the 15 N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 204523-09-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-Y0337S1. | |
| L-Cysteine hydrochloride | L-Cysteine hydrochloride is an orally active conditionally essential amino acid , which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 52-89-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-Y0337A. | |
| L-Cysteine hydrochloride hydrate | L-Cysteine hydrochloride hydrate is an orally active and essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate regulates CBS/H2S pathway, inhibits NF-κB activation and insulin and ghrelin secretion. L-Cysteine hydrochloride hydrate reduces blood sugar, vascular inflammation markers and appetite. L-Cysteine hydrochloride hydrate induces kidney damage. L-Cysteine hydrochloride hydrate can be used in the study of neurological diseases and diabetes [1] [2] [3] [4] [5] [6] [7] [8] [9]. Uses: Scientific research. Group: Natural products. CAS No. 7048-4-6. Pack Sizes: 10 mM * 1 mL; 10 g; 25 g. Product ID: HY-W016715. | |
| L-Cysteine (hydrochloride hydrate) (Standard) | L-Cysteine (hydrochloride hydrate) (Standard) is the analytical standard of L-Cysteine (hydrochloride hydrate). This product is intended for research and analytical applications. L-Cysteine hydrochloride hydrate is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans [1]. Uses: Scientific research. Group: Natural products. CAS No. 7048-4-6. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W016715R. | |
| Macimorelin | Macimorelin (also known as AEZS-130, EP-1572) is a novel synthetic small molecule, acting as a ghrelin agonist, that is orally active and stimulates the secretion of growth hormone (GH). Based on results of Phase 1 studies, AEZS-130 has potential applications for the treatment of cachexia, a condition frequently associated with severe chronic diseases. In addition to the therapeutic application, a Phase 3 trial with AEZS-130 as a diagnostic test for growth hormone deficiencies in adults has been completed. Synonyms: AEZS-130; AEZS 130; AEZS130; EP-1572; EP1572; EP 1572; JMV 1843; JMV-1843; 2-amino-N-((R)-1-(((R)-1-formamido-2-(1H-indol-3-yl)ethyl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-methylpropanamide. Grades: 98%. CAS No. 381231-18-1. Molecular formula: C26H30N6O3. Mole weight: 474.56. | |
| Obestatin (human) | Obestatin is a 23 amino acid peptide hormone which is formed by cleavage of the ghrelin and obestatin prepropeptide. It can suppress food intake and reduce body weight-gain in rats. Synonyms: C16102; Obestatin. Grades: ≥95% by HPLC. CAS No. 1081110-72-6. Molecular formula: C116H176N32O33. Mole weight: 2546.86. | |
| Obestatin (rat) | Obestatin is a 23 amino acid bioactive peptide that encoded by the ghrelin gene. It can suppress food intake and reduce body weight-gain in rats. Synonyms: H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2; L-phenylalanyl-L-asparagyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alpha-aspartyl-L-valyl-glycyl-L-isoleucyl-L-lysyl-L-leucyl-L-seryl-glycyl-L-alanyl-L-glutaminyl-L-tyrosyl-L-glutaminyl-L-glutaminyl-L-histidyl-glycyl-L-arginyl-L-alanyl-L-leucinamide; Obestatin (mouse, rat). Grades: ≥95% by HPLC. CAS No. 869705-22-6. Molecular formula: C114H174N34O31. Mole weight: 2516.84. | |
| Octanoyl coenzyme A lithium salt | Octanoyl coenzyme A lithium salt acts as a acyl group carrier. This is a medium-chain fatty acid convalently linked to coenzyme A. Applications: A donor molecule for the octanylation of ghrelin and other peptides. Group: Coenzymes. Synonyms: Capryloyl coenzyme A lithium salt. CAS No. 324518-20-9. Purity: ≥95%. Mole weight: 893.73. Appearance: Powder. Form: Solid. Capryloyl coenzyme A lithium salt; Octanoyl coenzyme A lithium salt; 324518-20-9. Cat No: COEC-028. |  |
| PF 04628935 | PF 04628935 is a potent antagonist/inverse agonist of the ghrelin receptor, growth hormone secretagogue receptor 1a (GHS-R1a) with an IC50 of 4.6 nM. It is orally bioavailable and exhibits reasonable brain penetration. Synonyms: 1-[2-[[2-Chloro-4-(2H-1,2,3-triazol-2-yl)phenyl]methyl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)ethanone; PF-04628935; PF04628935; PF 04628935; PF-4628935; PF4628935; PF 4628935. Grades: ≥98% by HPLC. CAS No. 1383719-97-8. Molecular formula: C24H26ClN7OS. Mole weight: 496.03. | |
| Relamorelin | Relamorelin is a synthetic, centrally penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR). It is potentially useful for the treatment of diabetic gastroparesis, chronic idiopathic constipation, and anorexia nervosa. It is a pentapeptide and an analogue of ghrelin. It produces increases in plasma growth hormone, prolactin, and cortisol levels, and increases appetite in humans. It is under development by Rhythm Pharmaceuticals and is in phase II clinical trials. Uses: Relamorelin is potentially useful for the treatment of diabetic gastroparesis, chronic idiopathic constipation, and anorexia nervosa. Synonyms: BIM28131; BIM 28131; BIM-28131; BIM-28163; BIM 28163; BIM28163; RM131; RM-131; RM 131; Relamorelin;N-((R)-3-(benzo[b]thiophen-3-yl)-1-(((R)-1-(((S)-1-((4-carbamoylpiperidin-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)piperidine-3-carboxamide;4. Grades: 98%. CAS No. 661472-41-9. Molecular formula: C43H50N8O5S. Mole weight: 790.98. | |
| Relamorelin TFA | Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K i of 0.42 nM for GHS-1a receptor. Relamorelin TFA is centrally penetrant. Relamorelin TFA increases growth hormone levels and accelerates gastric emptying. Relamorelin TFA has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Peptides. Alternative Names: RM-131 TFA; BIM-28131 TFA. CAS No. 2863659-22-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19884B. | |
| Tabimorelin Hemifumarate | The hemifumarete salt form of tabimorelin, which is found to be an agonist of ghrelin receptor (GHS-R1a) so that could be used in the treatment of growth hormone deficit. Synonyms: Tabimorelin Hemifumarate; N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-Dimethyl-D-phenylalaninamide Hemifumarate; NN 703 Hemifumarate; NNC 26-0703 Hemifumarate. Grades: > 95%. CAS No. 242143-80-2. Molecular formula: C32H40N4O3.1/2C4H4O4. Mole weight: 586.73. | |
| Tacalcitol Impurity 1 | One of the impurities of Tacalcitol, which is a ghrelin receptor agonist and could be used against growth hormone deficit. Synonyms: 1,?3-Cyclohexanediol, 4-methylene-5-[(2E)?-2-[(1R,?3aS,?7aR)?-octahydro-1-[(1R,?4S)?-4-hydroxy-1,?5-dimethylhexyl]?-7a-methyl-4H-inden-4-ylidene]?ethylidene]?-, (1R,?3S,?5Z)?-. Grades: > 95%. CAS No. 57333-95-6. Molecular formula: C27H44O3. Mole weight: 416.65. | |
| TC-G-1008 | TC-G-1008, also known as GPR39-C3, is a potent and orally available GPR39 agonist (EC50= 0.4 and 0.8 nM for rat and human receptors respectively) with great selectivity for GPR39 over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Synonyms: GPR39-C3, GPR39C3, GPR39 C3, TC-G-1008, TC-G1008, TC-G 1008, TCG-1008, TCG1008, TCG 1008; N- [3-chloro-4- [ [ [2- (methylamino) -6-pyridin-2-ylpyrimidin-4-yl] amino] methyl] phenyl] methanesulfonamide; GPR39-C3; N- (3-chloro-4- ( ( (2- (methylamino) -6- (2-pyridinyl) -4-pyrimidinyl) amino) methyl) phenyl) methanesulfonamide; TC-G 1008. CAS No. 1621175-65-2. Molecular formula: C18H19ClN6O2S. Mole weight: 418.9. | |
| TM N1324 | TM N1324 is an orally bioavailable, potent and selective GPR39 agonist. It inhibits the release of ghrelin and somatostatin from primary gastric mucosa cells in vitro. Synonyms: 4-(2-Chloro-4-fluorophenyl)-1,4,5,7-tetrahydro-3-methyl-1-(9H-purin-6-yl)-6H-pyrazolo[3,4-b]pyridin-6-one. Grades: ≥98% by HPLC. CAS No. 1144477-35-9. Molecular formula: C18H13ClFN7O. Mole weight: 397.79. | |
| Ulimorelin | Ulimorelin (TZP-101) is a ghrelin receptor (GRLN) agonist with an EC 50 of 29 nM and a K i of 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at α1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TZP-101. CAS No. 842131-33-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-14903. | |
| YIL781 | YIL781 is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 produces a greater improvement in glucose homeostasis in rats. YIL781 inhibits the calcium response induced by ghrelin with pIC 50 values of 7.90 and 8.27, respectively [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 875258-85-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-13964. | |
| YIL 781 | YIL 781 is a ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM) with no significant affinity for the motilin receptor (Ki = 6 μM). YIL 781 inhibits ghrelin to reduce insulin secretion both in vivo and in vitro. YIL 781 may be beneficial for the treatment of obesity and diabetes. Uses: Potential treatment of obesity and diabetes. Synonyms: YIL 781; YIL781; YIL-781; 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone; KB-276128; KB 276128; KB276128. Grades: ≥98% by HPLC. CAS No. 875258-85-8. Molecular formula: C24H28FN3O2. Mole weight: 409.51. | |
| YIL781 hydrochloride | YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL781 hydrochloride inhibits the calcium response induced by ghrelin with pIC 50 values of 7.90 and 8.27, respectively [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1640226-17-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13964A. | |
| YIL 781, Hydrochloride Salt | Ghrelin receptor antagonist (GHS-R1a) (Ki = 17nM). Displays no significant affinity for the motilin receptor (Ki = 6uM). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro. Improves glucose homeostasis in vivo. Group: Biochemicals. Alternative Names: 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone. Grades: Highly Purified. CAS No. 875258-85-8. Pack Sizes: 5mg. Molecular Formula: C??H??FN?O?.HCl, Molecular Weight: 445.96. US Biological Life Sciences. | Worldwide |
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