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GLP-1 receptor agonist 10 (compound 42) is an agonist of GLP Receptor. GLP-1 receptor agonist 10 inhibits food intake and reduces glucose excursion in mice. GLP-1 receptor agonist 10 can be used in the study of type 2 diabetes (T2DM) and obesity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3015555-46-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153798.
GLP-1 receptor agonist 12
GLP-1 receptor agonist 12 (compound 20A) is an agonist of GLP Receptor. GLP-1 receptor agonist 12 can be used in the study of diseases such as diabetes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2775376-50-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153816.
GLP-1 receptor agonist 2
GLP-1 receptor agonist 2 is a glucagon-like peptide-1 receptor (GLP-1R) agonist. Uses: Scientific research. Group: Signaling pathways. CAS No. 2230197-64-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-112679.
GLP-1 receptor agonist 7
GLP-1 receptor agonist 7 is a potent agonist of glucagon-like peptide-1 ( GLP-1 ). GLP-1 receptor agonist 7 has the potential for the research of GLP-1-associated diseases, disorders, and conditions including diabetes mellitus (extracted from patent WO2021219019A1, compound 130b) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2736447-04-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-145412.
(1R)-GLP-1 receptor agonist 12
(1R)-GLP-1 receptor agonist 12 is the isomer of GLP-1 receptor agonist 12 (HY-153816) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2775376-51-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153816A.
8-Glycine-36-L-argininamide-7-36-Glucagon-like peptide 1 (Octodon degus) TFA is a long acting GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2.TFA; L-Histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-lysylglycyl-L-argininamide trifluoroacetic acid; 7-36-Glucagon-like peptide 1 (Octodon degus), 8-glycine-36-L-argininamide-, trifluoroacetate; Albiglutide TFA; [Gly8,Arg36]-GLP 1 (7-36) amide (Octodon degus) TFA. Grades: ≥95%. Molecular formula: C150H225F3N40O47. Mole weight: 3397.63.
BETP
BETP is a positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor, displaying no effect on GLP-2, GIP, PTH or glucagon receptors. BETP promotes oxyntomodulin binding to GLP-1 receptor. It potentiates oxyntomodulin-mediated GLP-1 receptor signaling in vitro and insulin secretion in vivo. Synonyms: 2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)pyrimidine. Grades: ≥98% by HPLC. CAS No. 1371569-69-5. Molecular formula: C20H17F3N2O2S. Mole weight: 406.42.
BMS 903452
G-protein-coupled receptor 119 agonists can stimulate glucose-dependent insulin release by direct action in the pancreas and promote secretion of the incretin GLP-1 by action in the gastrointestinal tract. BMS-903452 is a selective G-protein-coupled receptor 119 (GRP119) agonist and it is efficacious in both acute and chronic in vivo rodent models of diabetes. Till now, no development was reported for the treatment of Type 2 diabetes mellitus using BMS-903452. Uses: Type 2 diabetes mellitus. Synonyms: BMS-903452; BMS 903452; BMS903452; 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one. Grades: 98%. CAS No. 1339944-47-6. Molecular formula: C21H19Cl2FN4O4S. Mole weight: 513.37.
Bofanglutide
Bofanglutide (GZR18) is an analog of glucagon-like peptide-1 (GLP-1), which exhibits agonistic activity for GLP-1 receptor , with an EC 50 of 0.677 nM. GZR18 ameliorates type 2 diabetes [1]. Uses: Scientific research. Group: Peptides. Alternative Names: GZR18. CAS No. 2668298-70-0. Pack Sizes: 1 mg. Product ID: HY-P10269.
Cholic acid 7-sulfate
Cholic acid 7-sulfate (7-Sulfocholic acid), a metabolite of Cholic acid, is a Takeda G-protein receptor 5 (TGR5) agonist. Cholic acid 7-sulfate can increase Tgr5 expression and induce GLP-1 secretion [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 7-Sulfocholic acid. CAS No. 60320-05-0. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-126855.
Cotadutide
Cotadutide (MEDI 0382) is a subcutaneous GLP-1 and glucagon receptor dual agonist that can be used to treat type 2 diabetes. Synonyms: MEDI 0382. CAS No. 1686108-82-6. Molecular formula: C167H252N42O55. Mole weight: 3728.03.
Des-Glu(3)-Semaglutide
Des-Glu(3)-Semaglutide is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: L-Histidyl-2-methylalanylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine; H-His-Aib-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH; Des-Glu(9)-Semaglutide. Molecular formula: C182H284N44O56. Mole weight: 3984.53.
Dulaglutide
Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: LY2189265. CAS No. 923950-08-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0120.
Ecnoglutide
Ecnoglutide (XW003) is a long-acting, cAMP-biased glucagon-like peptide 1 (GLP-1) receptor agonist. Ecnoglutide can be used for research of T2DM and obesity [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: XW003. CAS No. 2459531-73-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3366.
Exenatide
Exenatide, naturally occured in the saliva of the Gila monster, an incretin mimetic that has glucoregulatory effect. As a glucagon-like peptide-1 (GLP-1) receptor agonist, it stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS activation pathways. Uses: Hypoglycemic agents. Synonyms: L-Serinamide, L-histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-; L-Histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serinamide; Exendin 3 (Heloderma horridum), 2-glycine-3-L-glutamic acid-; Exendin 4 (Heloderma suspectum); AC 2993; AC 2993A; AC 2993LAR; Bydureon; Byetta; DA 3091; EQW; Exatenide; Exenatide LAR; Exendin 4; Exendin-4; ITCA 650; LAEx4; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. CAS No. 141758-74-9. Molecular formula: C184H282N50O60S. Mole weight: 4186.56.
Exenatide acetate
Exenatide acetate is a potent peptide agonist of the glucagon-like peptide 1 (GLP-1) receptor with Ki value of 136 pM. It is a 39 amino acid peptide, which increases intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors. It was first isolated from the venom of H. horridum and consequently synthesized. It stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS activation pathways via a GLP-1 receptor-dependent mechanism. It also stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells. It protects hippocampal neurons against glutamate-induced apoptosis, suggesting utility in neurodegenerative diseases. It also has anxiolytic and anti-depressant effects and induces satiety. It is an incretin mimetic approved for type 2 diabetes mellitus treatment. It also has neurotrophic/protective activity in cellular and animal models of stroke, Alzheimer's and Parkinson's diseases. Synonyms: L-Serinamide, L-histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-, acetate (1:x); Exendin 4 (Heloderma suspectum), acetate; Exendin-4 acetate; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2.CH3CO2H. Grades: >98%. CAS No. 914454-01-6. Molecular formula: C184H282N50O60S.C2H4O2. Mole weight: 4246.61.
Fmoc-His-Aib-OH TFA
An intermediate in the synthesis of Semaglutide, an agonist of glucagon-like peptide-1 (GLP-1) receptor that is developed to treat type 2 diabetes. Grades: ≥98%. CAS No. 1446013-08-6. Molecular formula: C25H26N4O5.C2HF3O2. Mole weight: 576.53.
GLP-1R agonist DMB
GLP-1R agonist DMB is a glucagon-like peptide-1 (GLP-1) receptor agonist used potentially for the treatment of type 2 diabetes. Uses: Potential treatment of type 2 diabetes. Synonyms: N-(tert-Butyl)-6,7-dichloro-3-(methylsulfonyl)quinoxalin-2-amine. Grades: 99%. CAS No. 281209-71-0. Molecular formula: C13H15Cl2N3O2S. Mole weight: 348.25.
Glucagon-Like Peptide 1 Receptor Agonist II (4- (3- (benzyloxy) phenyl) -2- (ethylsulfinyl) -6- (trifluoromethyl) pyrimidine, Glucagon-Like Peptide 1 Receptor Agonist II, Compound B)
A pyrimidine small molecule that acts as a GLP-1 allosteric agonist that induces cAMP signaling in HEK293 cells expressing the GLP-1 receptor with EC50 = 0.66uM and 99% efficacy (similar data with rat GLP-1 receptor), does not compete with radiolabelled GLP-1 in receptor binding assays, and is not active in cells expressing the GLP-2, GIP, PTH, or glucagon receptors. In rodent islets, insulin secretion increases in a dose-dependent and glucose-dependent manner, either alone or in an additive fashion when combined with the endogenous GLP-1 peptide. In vivo, this molecule exhibits insulinotropic effects when dosed at 10mg/kg in SD rats undergoing an IVGTT and a hyperglycemic clamp. It is also shown to increase insulin secretion in perifusion assays involving normal and diabetic human islets ex vivo, at concentrations between 1 and 10uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Glutaminyl-Methionyl-Glutamyl-Glutamyl-Glutamyl-Alanyl-Valyl-Arginine Trifluoroacetate is a metabolite from Exenatide trypsin (Exenatide Acetate, E957300) digestion. Exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. Group: Biochemicals. Grades: Highly Purified. CAS No. 868249-03-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C41H66F3N12O17S, Molecular Weight: 1088.08999999999. US Biological Life Sciences.
Worldwide
GPBAR-A
GPBAR-A is a GPBA receptor agonist. GPBAR-A increases GLP-1 secretion from intestinal cultures. Synonyms: GPBAR-A; GPBAR A; GPBARA; 4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one. Grades: ≥98% by HPLC. CAS No. 877052-79-4. Molecular formula: C23H15F7N2O2. Mole weight: 484.37.
A pyrimidine compound that acts as an effective GPR119 agonist (EC50=2.5uM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward B-adrenergic or GLP-1 receptors. Shown to enhance 16.8mM glucose-induced insulin secretion from murine MIN-6 B-cells (mU/20 min=0.44 and 0.22, respectively, with or without 10uM AS1269574) in vitro and improve glucose tolerance in normal mice (100mg/kg; p.o.) without any significant hypoglycemic effect in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 330981-72-1. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Liraglutide
Liraglutide is a glucagon-like peptide-1 ( GLP-1 ) receptor agonist used clinically to treat type 2 diabetes mellitus. Uses: Scientific research. Group: Peptides. CAS No. 204656-20-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0014.
Lixisenatide
Lixisenatide is a GLP-1 receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of proinflammatory cytokines, and blocks of cellular signaling pathways. Lixisenatide decreases atheroma plaque size and instability in Apoe -/- Irs 2+/- mice by reprogramming macrophages towards an M2 phenotype, which leads to reduced inflammation [2] [3] [5]. Uses: Scientific research. Group: Peptides. CAS No. 320367-13-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0119.
Lixisenatide
Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used in the treatment of type 2 diabetes mellitus (T2DM). Synonyms: ZP-10(Des-Pro38)-Exendin-4-(Lys)6, amide; ZP10A peptide; His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-NH2; L-histidyl-glycyl-L-alpha-glutamyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparagyl-glycyl-glycyl-L-prolyl-L-seryl-L-seryl-glycyl-L-alanyl-L-prolyl-L-prolyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysyl-L-lysyl-L-lysinamide; AQVE-10010; Des-38-proline-exendine-4 (Heloderma suspectum)-(1-39)-peptidylpenta-L-lysyl-L-lysinamide. Grades: ≥95%. CAS No. 320367-13-3. Molecular formula: C215H347N61O65S. Mole weight: 4858.48.
Lixisenatide acetate
Lixisenatide acetate is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used in the treatment of type 2 diabetes mellitus (T2DM). Uses: Scientific research. Group: Peptides. CAS No. 1997361-87-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0119A.
Maridebart cafraglutide
Maridebart cafraglutide (AMG 133) is an antibody-peptide conjugate acting as a GLP-1 receptor agonist and an antagonist of the GIP receptor. Maridebart cafraglutide reduces body weight and improve metabolic markers in male obese mice and cynomolgus monkeys. Maridebart cafraglutide is promising for research of obesity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMG 133. CAS No. 2887445-76-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-164535.
Mazdutide
Mazdutide is a long-acting glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist. Mazdutide has been use in the research of type 2 diabetes mellitus (T2DM). Synonyms: IBI362; IBI 362; IBI-362; LY3305677; LY 3305677; LY-3305677; OXM3; OXM-3; OXM 3. CAS No. 2259884-03-0. Molecular formula: C207H317N45O65. Mole weight: 4476.
MBX-2982
MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion. Preclinical data indicate that MBX-2982 is a potent selective orally-active GPR119 agonist that functions through a unique dual mechanism of action. First, it acts directly on the beta cell to increase insulin secretion. In addition, MBX-2982 stimulates release of the incretin GLP-1 from the gut. This dual action is unique and may offer improved glucose homeostasis over existing diabetes therapies, with potential for weight loss and improved islet health. Synonyms: Pyrimidine, MBX-2982; MBX 2982; MBX2982; SAR-260093; SAR260093; SAR 260093; 5-ethyl-2-(4-(4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-thiazolyl)-1-piperidinyl)-; 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)thiazole; B5TRY67L51. Grades: 98%. CAS No. 1037792-44-1. Molecular formula: C22H24N8OS. Mole weight: 448.549.
Octa(OtBu)-Glu-OtBu
An intermediate in the synthesis of Semaglutide, an agonist of glucagon-like peptide-1 (GLP-1) receptor that is developed to treat type 2 diabetes. Synonyms: L-Glutamic acid, N-[18-(1,1-dimethylethoxy)-1,18-dioxooctadecyl]-, 1-(1,1-dimethylethyl) ester. CAS No. 1188328-39-3. Molecular formula: C31H57NO7. Mole weight: 555.79.
Orforglipron
Orforglipron (LY3502970) (Compound 67) is an orally active agonist for Glucagon-like peptide-1 receptor ( GLP-1R ), which exhibits potency in ameliorates the type 2 diabete [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY3502970; GLP-1 receptor agonist 1. CAS No. 2212020-52-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-112185.
Oxyntomodulin (bovine, porcine)
Oxyntomodulin (bovine, porcine), a 37-amino acid peptide hormone, is a glucagon-like peptide 1 (GLP-1) receptor agonist [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Glucagon-37 (bovine, porcine). CAS No. 62340-29-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1144.
Oxyntomodulin (porcine, bovine)
Oxyntomodulin is a naturally peptide hormone found in the colon, produced by the oxyntic (fundic) cells of the oxyntic (fundic) mucosa. It has been found to suppress appetite. Oxyntomodulin acts as a glucagon-like peptide 1 (GLP-1) receptor agonist. Synonyms: Glucagon (1-37), porcine; Oxyntomodulin, porcine; His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-Lys-Arg-Asn-Lys-Asn-Asn-Ile-Ala. Grades: ≥96% by HPLC. CAS No. 62340-29-8. Molecular formula: C192H295N59O60S. Mole weight: 4421.86.
PB-718
PB-718 is a dual agonist of GLP-1 and glucagon receptor. PB-718 has been used in the research of weight loss and type 2 diabetes mellitus (T2DM). In addition, PB-718 can reduce lipid accumulation in liver which prevents hepatic cell death and consequent liver fibrosis. Synonyms: PB 718; PB718.
Retatrutide
Retatrutide is a triple glucagon, GIP, and GLP-1 receptor agonist. Retatrutide showed glucose control and weight loss in patients with type 2 diabetes mellitus (T2DM). Synonyms: LY3437943; LY 3437943; LY-3437943. Grades: 98% by HPLC. CAS No. 2381089-83-2. Molecular formula: C221H342N46O68. Mole weight: 4731.33.
SAR441255
SAR441255 is a synthetic peptide agonist of the GLP-1, GCG, and GIP receptors. SAR441255 showed substantial body weight loss and improved glucose control in diabetic obese monkeys. Synonyms: H-Aib-HGTFTSDLSKL-K(γGlu-γGlu-Palm acid)-EEQRQ-AibEFIEWLKA-dAla-GPPS-Aib-KPPPK-NH2. Molecular formula: C206H323N51O66. Mole weight: 4570.06.
Semaglutide
Semaglutide, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist. Semaglutide has the potential for type 2 diabetes treatment. Uses: Scientific research. Group: Peptides. CAS No. 910463-68-2. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-114118.
Semaglutide
Semaglutide is an agonist of glucagon-like peptide-1 (GLP-1) receptor that is developed to treat type 2 diabetes. It reduces blood sugar via increasing the production of insulin. On Oct 18, 2017, Novo Nordisk received positive 16-0 vote from FDA Advisory Committee in favor of approval for Semaglutide. Uses: The treatment of type 2 diabetes. Synonyms: L-Histidyl-2-methylalanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine; H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH; BGM 134; NN 9535; NN 9536; NNC 0113-0217; Ozempic; Rybelsus; Wegovy; (3S, 9S, 12S, 15S, 18S, 21S, 24S, 27S, 30S, 33S, 36S, 39S, 45S, 48S, 51S, 54S, 81S)-54-(((6S, 12S, 15S, 18S, 21S, 24S, 27S, 30S, 33S)-21-(.. Grades: >98%. CAS No. 910463-68-2. Molecular formula: C187H291N45O59. Mole weight: 4113.64.
Semaglutide acetate
Semaglutide acetate, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist. Semaglutide acetate has the potential for type 2 diabetes treatment. Uses: Scientific research. Group: Peptides. CAS No. 1997361-85-9. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-114118B.
Semaglutide-[d15]
Semaglutide-[d15] is the labelled analogue of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: Semaglutide-d15; H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val(D8)-Ser-Ser-Tyr-Leu(D7)-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Molecular formula: C187H276D15N45O59. Mole weight: 4128.73.
Semaglutide Impurity 10
Semaglutide Impurity 10 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Molecular formula: C188H291N45O61. Mole weight: 4157.65.
Semaglutide Impurity 11
Semaglutide Impurity 11 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Molecular formula: C187H291N43O59. Mole weight: 4085.63.
Semaglutide Impurity 12
Semaglutide Impurity 12 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: 3,6-Dioxa-9,14-diazadotriacontanedioic acid, 13-[(1,1-dimethylethoxy)carbonyl]-10,15-dioxo-, 32-(1,1-dimethylethyl) ester, (13R)-; 32-(1,1-Dimethylethyl) (13R)-13-[(1,1-dimethylethoxy)carbonyl]-10,15-dioxo-3,6-dioxa-9,14-diazadotriacontanedioate. Molecular formula: C37H68N2O10. Mole weight: 700.96.
Semaglutide Impurity 13
Semaglutide Impurity 13 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: 3,6,12,15-Tetraoxa-9-azaheptadecan-1-oic acid, 17-[[(4R)-5-(1,1-dimethylethoxy)-4-[[18-(1,1-dimethylethoxy)-1,18-dioxooctadecyl]amino]-1,5-dioxopentyl]amino]-10-oxo-; (22R)-43,43-Dimethyl-22-{[(2-methyl-2-propanyl)oxy]carbonyl}-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontan-1-oic acid; 3,6,12,15-Tetraoxa-9,18,23-triazahentetracontanedioic acid, 22-[(1,1-dimethylethoxy)carbonyl]-10,19,24-trioxo-, 41-(1,1-dimethylethyl) ester, (22R)-; 41-(1,1-Dimethylethyl) (22R)-22-[(1,1-dimethylethoxy)carbonyl]-10,19,24-trioxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontanedioate. Molecular formula: C43H79N3O13. Mole weight: 846.11.
Semaglutide Impurity 14
Semaglutide Impurity 14 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Molecular formula: C43H80N4O12. Mole weight: 845.13.
Semaglutide Impurity 15
Semaglutide Impurity 15 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Molecular formula: C49H90N4O16. Mole weight: 991.27.
Semaglutide Impurity 16
Semaglutide Impurity 16 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: Glycine, N-L-α-glutamyl-, 5-(1,1-dimethylethyl) ester; Glutaramic acid, 4-amino-N-(carboxymethyl)-, 1-tert-butyl ester, L-; (S)-(2-amino-5-(tert-butoxy)-5-oxopentanoyl)glycine; H-Glu(OtBu)-Gly-OH; ({(2S)-2-Amino-5-[(2-methyl-2-propanyl)oxy]-5-oxopentanoyl}amino)acetic acid. CAS No. 23406-82-8. Molecular formula: C11H20N2O5. Mole weight: 260.29.
Semaglutide Impurity 17
Semaglutide Impurity 17 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Molecular formula: C23H33N3O8. Mole weight: 479.53.
Semaglutide Impurity 18
Semaglutide Impurity 18 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Molecular formula: C15H27N3O6. Mole weight: 345.40.
Semaglutide Impurity 19
Semaglutide Impurity 19 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Molecular formula: C46H58N6O9. Mole weight: 839.00.
Semaglutide Impurity 1 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: L-Histidyl-2-methylalanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-(L-tryptophyl-hydroxybenzyl)-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine; H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-(Trp-hydroxybenzyl)-Leu-Val-Arg-Gly-Arg-Gly-OH. Molecular formula: C194H297N45O60. Mole weight: 4219.77.
Semaglutide Impurity 2
Semaglutide Impurity 2 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: Na-(((9H-fluoren-9-yl)methoxy)carbonyl)-1-(4-((tert-butyldiphenylsilyl)oxy)benzyl)-L-tryptophan. Molecular formula: C49H46N2O5Si. Mole weight: 771.00.
Semaglutide Impurity 20
Semaglutide Impurity 20 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Molecular formula: C41H48N6O9. Mole weight: 768.87.
Semaglutide Impurity 21
Semaglutide Impurity 21 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. CAS No. 2377584-78-4. Molecular formula: C26H42N6O9. Mole weight: 582.66.
Semaglutide Impurity 22
Semaglutide Impurity 22 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Molecular formula: C45H56N6O9. Mole weight: 824.98.
Semaglutide Impurity 23
Semaglutide Impurity 23 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Molecular formula: C49H63N7O10. Mole weight: 910.08.
Semaglutide Impurity 3 (P3 Semaglutide)
Semaglutide Impurity 3 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine; H-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Molecular formula: C126H206N30O36. Mole weight: 2717.21.
Semaglutide Impurity 4 (U7 Semaglutide)
Semaglutide Impurity 4 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Molecular formula: C29H51N5O14. Mole weight: 693.75.
Semaglutide Impurity 5 (U6 Semaglutide)
Semaglutide Impurity 5 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Molecular formula: C27H47N5O14. Mole weight: 665.69.
Semaglutide Impurity 6
Semaglutide Impurity 6 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: 3,6-Dioxa-9,14-diazadotriacontanedioic acid, 13-[(1,1-dimethylethoxy)carbonyl]-10,15-dioxo-, 32-(1,1-dimethylethyl) ester, (13S)-; 32-(1,1-Dimethylethyl) (13S)-13-[(1,1-dimethylethoxy)carbonyl]-10,15-dioxo-3,6-dioxa-9,14-diazadotriacontanedioate. CAS No. 1671100-14-3. Molecular formula: C37H68N2O10. Mole weight: 700.96.
Semaglutide Impurity 7
Semaglutide Impurity 7 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. It is also an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Synonyms: 1-tert-Butyl 18-(2,5-dioxopyrrolidin-1-yl) octadecanedioate; Boc-C16-NHS ester; t-butyl-octadecanedioate-NHS ester; Succinimidyl tert-butyl octadecandioate; Octadecanedioic acid tert-butyl ester 2,5-dioxopyrrolidin-1-yl ester; Octadecanedioic acid, 1-(1,1-dimethylethyl) 18-(2,5-dioxo-1-pyrrolidinyl) ester; 1-(1,1-Dimethylethyl) 18-(2,5-dioxo-1-pyrrolidinyl) octadecanedioate; Octadecanoic acid, 18-[(2,5-dioxo-1-pyrrolidinyl)oxy]-18-oxo-, 1,1-dimethylethyl ester; 18-tert-Butoxy-18-oxooctadecanoic acid succinimidyl ester. CAS No. 843666-34-2. Molecular formula: C26H45NO6. Mole weight: 467.65.
Semaglutide Impurity 8
Semaglutide Impurity 8 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: L-Glutamic acid, N-[18-(1,1-dimethylethoxy)-1,18-dioxooctadecyl]-, 1-(1,1-dimethylethyl) 5-(2,5-dioxo-1-pyrrolidinyl) ester; 1-(1,1-Dimethylethyl) 5-(2,5-dioxo-1-pyrrolidinyl) N-[18-(1,1-dimethylethoxy)-1,18-dioxooctadecyl]-L-glutamate; (S) -2- (17-tert-Butoxycarbonylheptadecanoylamino) pentanedioic acid 1-tert-butyl ester 5-(2,5-dioxopyrrolidin-1-yl) ester; 5-(2,5-Dioxo-1-pyrrolidinyl) 1-(2-methyl-2-propanyl) N-{18-[(2-methyl-2-propanyl)oxy]-18-oxooctadecanoyl}-L-glutamate; N-[18-(1,1-Dimethylethoxy)-1,18-dioxooctadecyl]-L-glutamic acid 1-(1,1-dimethylethyl) 5-(2,5-dioxo-1-pyrrolidinyl) ester. Grades: ≥95%. CAS No. 1188328-22-4. Molecular formula: C35H60N2O9. Mole weight: 652.87.
Semaglutide Impurity 9
Semaglutide Impurity 9 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: L-2-oxo-Histidyl-2-methylalanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine; (2-oxo-His)-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Molecular formula: C187H289N45O60. Mole weight: 4127.62.
Semaglutide intermediate
Semaglutide intermediate is an intermediate of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: (S)-21,39-di-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 9,18,23-trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylate; 17- ( (S) -1-tert-Butoxycarbonyl-3-{2-[2- ({2-[2- (2, 5-dioxopyrrolidin-1-yloxycarbonylmethoxy) ethoxy]ethylcarbamoyl}methoxy) ethoxy]-ethylcarbamoyl}propylcarbamoyl) heptadecanoic acid tert-butyl ester; Octadecanoic acid, 18-[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]-22-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4,13,22-trioxo-8,11,17,20-tetraoxa-5,14-diazadocos-1-yl]amino]-18-oxo-, 1,1-dimethylethyl ester; Bis(2-methyl-2-propanyl) (22S)-1-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1,10,19,24-tetraoxo-3,6,12,15-tetraoxa-9,18,23-triazatetracontane-22,40-dicarboxylate; tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu. Grades: ≥95%. CAS No. 1118767-15-9. Molecular formula: C47H82N4O15. Mole weight: 943.19.
Semaglutide intermediate P29
An intermediate of Semaglutide, an agonist of glucagon-like peptide-1 (GLP-1) receptor that is developed to treat type 2 diabetes. Synonyms: Semaglutide [sequence (9-37)]; L-α-Glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine; H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Grades: ≥95%. CAS No. 1169630-82-3. Molecular formula: C142H216N38O45. Mole weight: 3175.47.
Semaglutide-[Phe-d5]
Semaglutide-[Phe-d5] is the labelled analogue of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: H-His-Aib-Glu-Gly-Thr-Phe(D5)-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH; Semaglutide D5; Semaglutide-d5. Molecular formula: C187H286D5N45O59. Mole weight: 4118.67.
Semaglutide-[Phe-d8]
Semaglutide-[Phe-d8] is the labelled analogue of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: H-His-Aib-Glu-Gly-Thr-Phe(D8)-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH; Semaglutide D8; Semaglutide-d8. Molecular formula: C187H283D8N45O59. Mole weight: 4121.69.
Semaglutide related compound 1
Semaglutide related compound 1 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: Semaglutide SZ Impurity 1; Semaglutide Iso Asp Impurity; H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Iso-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Molecular formula: C187H291N45O59. Mole weight: 4113.64.
Semaglutide related compound 10
Semaglutide related compound 10 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: Semaglutide SZ Impurity 10. Molecular formula: C190H295N47O61. Mole weight: 4213.72.
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