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| Product | Description | |
|---|---|---|
| Head activator | The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37. Synonyms: Pglu-pro-pro-gly-gly-ser-lys-val-ile-leu-phe; Hydra Peptide; HHAP. CAS No. 79943-68-3. Molecular formula: C54H84N12O14. Mole weight: 1125.33. |  |
| Head activator neuropeptide | Head activator neuropeptide is a mitogen for mammalian cell lines of neuronal or neuroendocrine origin. Head activator neuropeptide signals by binding GPR37 and stimulates cells to enter mitosis [1]. Uses: Scientific research. Group: Peptides. CAS No. 79943-68-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3840. |  |
| (1R,3R)-RSL3 | (1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) ( ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1219810-15-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100218C. | |
| CTPαS | CTPαS, a molecule activator of soluble guanylate cyclase (sGC), is vying for a preeminent position in the study of nitric oxide signaling pathway. With its therapeutic potential locked and loaded, CTPαS is turning heads in the scientific community, demonstrating potential efficacy in addressing cardiovascular diseases such as hypertension and pulmonary arterial hypertension, as well as a wide range of central nervous system conditions, including neurodegenerative diseases and pain management alike. Synonyms: Cytidine-5'-(α-thio)-triphosphate, Sodium salt (1 : 1 Mixture of Rp and Sp isomers). Grades: ≥ 95% by HPLC. Molecular formula: C9H16N3O13P3S (free acid). Mole weight: 499.21 (free acid). | |
| HJC0152 | HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor against human head and neck squamous cell carcinoma (HNSCC). Uses: Designed for use in research and industrial production. Additional or Alternative Names: HJC0152; HJC 0152; HJC-0152. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1420290-99-8. Molecular formula: C15H14Cl3N3O4. Mole weight: 406.64. Purity: >98%. IUPACName: 2-(2-Amino-ethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide Hydrochloride. Canonical SMILES: O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2OCCN.[H]Cl. Product ID: ACM1420290998. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Tigilanol tiglate | Tigilanol tiglate (EBC-46) is a protein kinase C ( PKC )/ C1 domain activator. Tigilanol tiglate is associated with mitochondrial/endoplasmic reticulum (ER) dysfunction, leading to activation of the unfolded protein response (UPRmt/ER) and subsequent induction of ATP depletion, organelles expansion, Caspase activation, gasdermin E cleavage, and terminal necrosis. Tigilanol tiglate, as a small anti-tumor molecule with immunomodulatory effects, can be used in the study of head and neck squamous cell carcinoma and soft tissue sarcoma [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EBC-46. CAS No. 943001-56-7. Pack Sizes: 1 mg. Product ID: HY-109076. | |
| Umbellulone | Offensive principle of the so-called "headache tree". Causes a painful cold sensation. Selective TRPA1 activator. Weak TRPM8 activator. Releases CGRP (calcitoningene-related peptide) after TRPA1 activation which leads to activation of trigeminovascular pathways and CGRP-mediated neurogenic vasodilatation relevant to produce headache/migraine. Group: Biochemicals. Grades: Highly Purified. CAS No. 546-78-1. Pack Sizes: 10mg. Molecular Formula: C10H14O. US Biological Life Sciences. |  Worldwide |
| 2-Chloroamphetamine Hydrochloride | 2-Chloroamphetamine Hydrochloride increases motor activity, and produces head-twitches in reserpinized mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 35334-29-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C9H13Cl2N, Molecular Weight: 206.11. US Biological Life Sciences. | Worldwide |
| Antimicrobial peptide scolopin-1 | Antimicrobial peptide scolopin-1 is an antimicrobial peptide produced by Scolopendra mutilans (Chinese red-headed centipede, Scolopendra subspinipes mutilans). It has antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Synonyms: AMP-scolopin 1; Phe-Leu-Pro-Lys-Met-Ser-Thr-Lys-Leu-Arg-Val-Pro-Tyr-Arg-Arg-Gly-Thr-Lys-Asp-Tyr-His. Grades: 96%. Molecular formula: C118H189N35O29S. Mole weight: 2594.08. | |
| Antimicrobial peptide scolopin-2 | Antimicrobial peptide scolopin-2 is an antimicrobial peptide produced by Scolopendra mutilans (Chinese red-headed centipede venom, Scolopendra subspinipes mutilans). It has antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Synonyms: AMP-scolopin 2; Gly-Ile-Leu-Lys-Lys-Phe-Met-Leu-His-Arg-Gly-Thr-Lys-Val-Tyr-Lys-Met-Arg-Thr-Leu-Ser-Lys-Arg-Ser-His. Grades: ≥97%. Molecular formula: C135H231N43O31S2. Mole weight: 3016.71. | |
| Betahistine | Betahistine is a H1 receptor agonist, which serves as a vasodilator. It is used in Meniere disease and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. It is an antivertigo drug first used for treating vertigo. It is also commonly used for patients with balance disorders. It is believed to act by reducing the asymmetrical functioning of sensory vestibular organs as well as by increasing vestibulocochlear blood flow. It also acts as a histamine H3-receptor antagonist which causes an increased output of histamine from histaminergic nerve endings which can further increase the direct H1-agonist activity. It has been listed. Uses: Betahistine is used in meniere disease and in vascular headaches. it is an antivertigo drug first used for treating vertigo. it is also commonly used for patients with balance disorders. Synonyms: N-methyl-2-pyridin-2-ylethanamine. Grades: 98 %. CAS No. 5638-76-6. Molecular formula: C8H12N2. Mole weight: 136.19. | |
| chrysanthemyl diphosphate synthase | Requires a divalent metal ion for activity, with Mg2+ being better than Mn2+. Chrysanthemyl diphosphate is a monoterpene with a non-head-to-tail linkage. It is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head-to-tail. The mechanism of its formation is similar to that of the early steps of squalene and phytoene biosynthesis. Chrysanthemyl diphosphate is the precursor of chrysanthemic acid, the acid half of the pyrethroid insecticides found in chrysanthemums. Group: Enzymes. Synonyms: CPPase. Enzyme Commission Number: EC 2.5.1.67. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2804; chrysanthemyl diphosphate synthase; EC 2.5.1.67; CPPase. Cat No: EXWM-2804. |  |
| cis-Diamineplatinum(II) dichloride | cis-Diamineplatinum(II) dichloride. Uses: Cisplatin is a cytostatic agent and it is used to treat various cancer types, including cancer of ovary, testis, lung, head, neck, bladder, neuroblastoma, and nephroblastoma, and hodgkin's disease and non-hodgkin lymphoma.cddp, also referred to as cisplatinum or cisplatin, is a yellow powder and has found widespread use a chemotherapeutic agent.cisplatin, combined with bleomycin and vinblastine or etoposide, produces cures in most patients with metastatic testicular cancer or germ cell cancer of the ovary. cisplatin also shows some activity against carcinomas of the head and neck, bladder, cervix, prostate, and lung. Group: Salt. Alternative Names: cis-Dichlorodiammine platinum(II). CAS No. 15663-27-1. Molecular formula: 300.05. Mole weight: Pt(NH3)2Cl2. Pt ≥65.0%. |  |
| Cytidine, N-?benzoyl-?3'-?deoxy-?3'-?[[ (4-?methoxyphenyl) ?diphenylmethyl]?amino]?-?2'-?O-?2-?propen-?1-?yl- | Cytidine, N-benzoyl-3'-deoxy-3'-[[(4-methoxyphenyl)diphenylmethyl]amino]-2'-O-2-propen-1-yl is a complex and formidable inhibitor of epidermal growth factor receptor kinase activity. With selectivity and potency, this compound is a key tool in the fight against various tumors, including non-small cell lung cancer, colorectal cancer, head and neck cancer, and pancreatic cancer. The power of this compound extends beyond the realm of tumors and into the world of infectious diseases, with significant efficacy against viruses such as hepatitis B and hepatitis C. CAS No. 2299283-60-4. Molecular formula: C39H38N4O6. Mole weight: 658.74. | |
| (E)-3,4,5-Trimethoxycinnamic acid | (E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABA A /BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT 2C and 5-HT 1A receptor, with IC 50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMCA. CAS No. 20329-98-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W050162. | |
| Enflurane | Enflurane, a volatile anaesthetic, is a potent inhibitor of high conductance Ca 2+ -activated K+ channels of Chara australis. Enflurane is an internal standard in monitoring halogenated volatile anaesthetics by headspace gas chromatography-mass spectrometry [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 13838-16-9. Pack Sizes: 100 mg. Product ID: HY-A0135. | |
| Flunarizine | Flunarizine is a selective calcium entry blocker, which has calmodulin binding properties and histamine H1 blocking activity. It may help to reduce the severity and duration of attacks of paralysis and is effective in rapid onset dystonia-parkinsonism. It is effective in the prophylaxis of migraine, vascular disease, occlusive peripheral, vertigo of central and peripheral origin. It is used as an adjuvant in the therapy of epilepsy. It has been shown to significantly reduce headache frequency and severity in both adults and children. It was discovered at Janssen Pharmaceutica in 1968. It has been listed. Uses: Flunarizine is effective in the prophylaxis of migraine, vascular disease, occlusive peripheral, vertigo of central and peripheral origin. it is used as an adjuvant in the therapy of epilepsy. Synonyms: R-14950; R 14950; R14950; Sibelium; Flunarizinum; Flunarizina; (E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine; 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine; Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, (E)-. Grades: 95%. CAS No. 52468-60-7. Molecular formula: C26H26F2N2. Mole weight: 404.50. | |
| Indomethacin, 2'-Trifluoromethyl (Indomethacin, 2'-Trifluoromethyl, Indomethacin, 2-CF3, CF3-Indomethacin, CF3-INDO) | A cell-permeable, bioavailable 2-trifluoromethyl analog of Indomethacin that acts as a highly potent, time-dependent inhibitor of cyclooxygenase -2 (COX-2; IC50=267 and 388nM for mouse and human COX-2, respectively) and its several mutant forms. Does not affect COX-1 activity even at high concentrations (IC50 >100uM). Interacts with human COX-2 with much greater affinity than indomethacin (KI = 1.5 vs 13uM) and blocks COX-2 dependent arachidonic acid oxygenation (IC50 = 150nM in 1483 human head and neck squamous cell carcinoma cells). Further, minimizes swelling in carrageenan-induced rat paw edema model (EC50 = 1.7mg/kg, p.o.) with no gastrointestinal bleeding at higher doses (10mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Lirilumab | Lirilumab (IPH2102) is an anti-KIR monoclonal antibody, and shows antitumor activity. Lirilumab can be used in Leukemia, squamous cell carcinoma of the head and neck (SCCHN) research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: IPH2102. CAS No. 1000676-41-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99208. | |
| Methysergide Maleate (5-HT Serotonin Receptor Antagonsit, Methysergide Maleate, UML-491) | An antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18uM. Originally developed in the 1960?s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments. Group: Biochemicals. Grades: Highly Purified. CAS No. 129-49-7. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?·C?H?O?. US Biological Life Sciences. | Worldwide |
| Mupadolimab | Mupadolimab is a humanized anti-CD73 monoclonal antibody that inhibits production of immunosuppressive adenosine in the tumour microenvironment, binding to CD73 on B cells leads to their activation (including increased antibody production). Mupadolimab was developed for the treatment of head and neck cancer, and NSCLC. Synonyms: CPI-006; CPI 006; CPI006. CAS No. 2451856-97-4. | |
| Nadolol | Nadolol (SQ-11725) is a non-selective and orally active β-adrenergic receptors blocker and is a substrate of organic anion transporting polypeptide 1A2 (OATP1A2). Nadolol has the the potential for high blood pressure, angina pectoris and vascular headaches research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SQ-11725. CAS No. 42200-33-9. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0804. | |
| Paroxetine | Paroxetine is an oral | |
| Redaporfin | This active molecular can be applicated as a photosensitizer for PDT (Photodynamic Therapy) of cancer. Redaporfin showed a great efficacy in the treatment of male BALB/c mice with subcutaneously implanted colon (CT26) tumours. Tumour can be regressed in 83% of the mice when given a treatment of Vascular-PDT with 1.5 mg/kg Redaporfin and a light dose of 74 J/cm². Now Redaporfin is in Phase I/II for treatment of head and neck cancer under the development of Luzitin. Uses: Head and neck cancer. Synonyms: F-2BMet; LUZ-11; F2BMet; LUZ11; F 2BMet; LUZ 11; 3,3',3'',3'''-(7H,8H,17H,18H-porphyrin-5,10,15,20-tetrayl)tetrakis(2,4-difluoro-N-methylbenzenesulfonamide. Grades: 98%. CAS No. 1224104-08-8. Molecular formula: C48H38F8N8O8S4. Mole weight: 1135.11. | |
| (R)-(+)-Nor Verapamil Hydrochloride | This active molecular is a chiral metabolite of Verapamil which is a calcium channel blocker applicated in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and cluster headaches recently. Uses: Chiral metabolite of verapamil. Synonyms: (αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-benzeneacetonitrile Hydrochloride; (R)-Norverapamil Hydrochloride;Agi-003; Agi 003; Agi003. Grades: 98%. CAS No. 123932-43-4. Molecular formula: C26H36N2O4. Mole weight: 447.04. | |
| SNC80 | SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a K i of 1.78 nM and an IC 50 of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC 50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant?like effects. SNC80 has the potential for multiple headache disorders treatment [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NIH 10815. CAS No. 156727-74-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101202. | |
| spermosin | The enzyme from the ascidian (Prochordate) Halocynthia roretzi is localized in the sperm head, and released during sperm activation. A proline-rich region is involved in binding to the vitelline coat of the egg. Belongs in peptidase family S1 (trypsin family). Group: Enzymes. Enzyme Commission Number: EC 3.4.21.99. CAS No. 89925-67-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4191; spermosin; EC 3.4.21.99; 89925-67-7. Cat No: EXWM-4191. | |
| Sumatriptan | Sumatriptan (GR 43175) is an orally active 5-HT1 receptor agonist with IC 50 s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT 1D , 5-HT 1B and 5-HT 1F receptors, respectively. Sumatriptan can be used for migraine headache research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GR 43175 free base. CAS No. 103628-46-2. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0121B. | |
| Sumatriptan | Sumatriptan is a Serotonin-1b and Serotonin-1d Receptor Agonist that acts selectively at 5HT1 receptors. It is a sulfonamide triptan with vasoconstrictor activity. It selectively binds to and activates serotonin 5-HT1D receptors in the central nervous system, thus constricts cerebral blood vessels. It may also relieve vascular headaches by decreasing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater. It is a medication used for the treatment of migraine headaches. Uses: Sumatriptan is a medication used for the treatment of migraine headaches. Synonyms: Imitrex; Sumatran; Sumax; Sumatriptanum; 1-[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]-N-methylmethanesulfonamide; (3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide; GR-43175; GR43175. Grades: 95%. CAS No. 103628-46-2. Molecular formula: C14H21N3O2S. Mole weight: 295.40. | |
| Sumatriptan-d6 succinate | Sumatriptan-d6 succinate is the deuterium labeled Sumatriptan succinate. Sumatriptan succinate is an orally active 5-HT1 receptor agonist with K i s of 17 nM, 27 nM and 100 nM for 5-HT1D , 5-HT1B and 5-HT1A receptors , respectively. Sumatriptan succinate can be used for migraine headache research [1] [2] [3]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: GR 43175C-d6. CAS No. 1215621-31-0. Pack Sizes: 1 mg. Product ID: HY-B0121BS. | |
| Sumatriptan succinate | Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with IC 50 s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT 1D , 5-HT 1B and 5-HT 1F receptors, respectively. Sumatriptan succinate can be used for migraine headache research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GR 43175 succinate. CAS No. 103628-48-4. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0121. | |
| TAK-659 dihydrochloride | TAK-659 is a potent spleen tyrosine kinase (syk) inhibitor under the development of Takeda Oncology, with potential anti-inflammatory, immunomodulating, and antineoplastic activities. TAK-659 may inhibit the activity of syk, which abrogates downstream BCR (B-cell receptor) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Phase I/II for the treatment Acute myeloid leukaemia, phase I for the treatment of Breast cancer, Gastrointestinal cancer, Head and neck cancer, Lymphoma, Non-small cell lung cancer and Solid tumours was on-going. Uses: Acute myeloid leukaemia;breast cancer; gastrointestinal cancer; head and neck cancer; lymphoma; non-small cell lung cancer; solid tumours most recent events. Synonyms: 6-(((1R,2S)-2-aminocyclohexyl)amino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one dihydrochloride; TAK659; TAK-659; TAK 659; TAK-659 HCl; TAK659 dihydrochloride. Grades: 98%. CAS No. 1312691-41-0. Molecular formula: C17H23Cl2FN6O. Mole weight: 417.31. | |
| Topiramate D-galactopyranose | Topiramate D-galactopyranose is a scientifically formulated pharmaceutical compound, used for studying epilepsy and migraine headaches. Marrying the prowess of anticonvulsant properties and the ability to curb repetitive neuronal firing, it exhibits a mechanism of action rooted in augmenting GABA receptor activity while diminishing glutamate receptor activity. Molecular formula: C18H31NO13S. Mole weight: 501.50. | |
| Valproic acid | Valproic acid (VPA) is an orally active HDAC inhibitor, with IC 50 in the range of 0.5 and 2 mM. Valproic acid inhibits HDAC1 ( IC 50 , 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. Alternative Names: Dipropylacetic Acid. CAS No. 99-66-1. Pack Sizes: 500 mg; 1 g; 5 g; 25 g. Product ID: HY-10585. | |
| Valproic acid-d4 | Valproic acid-d 4 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: VPA-d4; 2-Propylpentanoic Acid-d4. CAS No. 87745-17-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-10585S. | |
| Valproic acid sodium | Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC 50 in the range of 0.5 and 2 mM, also inhibits HDAC1 ( IC 50 , 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. Alternative Names: Sodium Valproate sodium. CAS No. 1069-66-5. Pack Sizes: 500 mg; 1 g; 5 g; 25 g. Product ID: HY-10585A. | |
| WAY 262611 dihydrochloride | WAY 262611 dihydrochloride is an inhibitor of Dickkopf-1 (DKK1), which antagonizes Wnt/β-Catenin signaling. DKK1 is a soluble inhibitor of Wnt-3a mediated Wnt/β-catenin signaling required for embryonic head development. Inhibition of DKK1 by WAY 262611 activates the Wnt signaling pathway and stimulates β-catenin/TCF-dependent transcription with an EC50 value of 0.63 μM. Synonyms: WAY-262611 dihydrochloride; WAY 262611 dihydrochloride; WAY262611 dihydrochloride; (1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine dihydrochloride. Grades: 99%. Molecular formula: C20H22N4.2HCl. Mole weight: 391.34. | |
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