Helicase Suppliers USA
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Product | Description | |
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ATP-dependent RNA helicase DDX5 (148-156) Quick inquiry Where to buy Suppliers range | ATP-dependent RNA helicase DDX5 (148-156) is a fragment of ATP-dependent RNA helicase DDX5. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. It can be used in Ovarian carcinoma research. Synonyms: DEAD box protein 5 (148-156); RNA helicase p68 (148-156). | |
ATP-dependent RNA helicase DDX5 (148-156) Quick inquiry Where to buy Suppliers range | Probable ATP-dependent RNA helicase DDX5 (UniProt:P17844). Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-049. | |
BLM Helicase Inhibitor, ML216 (ML-216, 1- (4-Fluoro-3- (trifluoromethyl) phenyl) -3- (5- (pyridin-4-yl) -1, 3, 4-thiadiazol-2-yl) urea) Quick inquiry Where to buy Suppliers range | A cell-permeable pyridinyl-thiadiazolylurea compound that selectively blocks Bloom's syndrome protein (BLM) helicase activity of both full-length as well as truncated BLM636-1298 forms (IC50 = 2.98 and 0.97uM, respectively). Competes with and reversibly blocks DNA binding to BLM. However, the inhibition appears to be non-competitive with respect to ATP. Exhibits anti-proliferative activity in cells expressing BLM, but not in those lacking BLM. Induces sister chromatid exchanges (SCEs) and enhances the sensitivity of BLM containing PSNF5 cells to aphidicolin without affecting PSNG13 cells that are devoid of BLM. Displays favorable microsomal (T1/2 > 1.2h) and plasma stability (~100% at 5h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?F?N?OS. US Biological Life Sciences. | Worldwide |
HLA-A_02_01 RNA-dependent helicase tetramer-YLLPAIVHI-APC labeled Quick inquiry Where to buy Suppliers range | HLA-A_02_01 RNA-dependent helicase tetramer-YLLPAIVHI-APC labeled. Uses: MHC-peptides Tetramer Class ?. Product ID: CPM-1-0293. | |
HLA-A_02_01 RNA-dependent helicase tetramer-YLLPAIVHI-PE labeled Quick inquiry Where to buy Suppliers range | HLA-A_02_01 RNA-dependent helicase tetramer-YLLPAIVHI-PE labeled. Uses: MHC-peptides Tetramer Class ?. Product ID: CPM-1-0311. | |
WRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 Quick inquiry Where to buy Suppliers range | The WRN Helicase Inhibitor, NSC 19630, also referenced under CAS 72835-26-8, controls the biological activity of WRN Helicase. This small molecule/inhibitor is primarily used for Cell Signaling applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 72835-26-8. Pack Sizes: 5MG. Mole weight: 183.16. Catalog: AP72835268. Assay: ≥97% (NMR). | |
7-Propargylamino-7-deaza-ddGTP - ATTO-633 Quick inquiry Where to buy Suppliers range | 7-Propargylamino-7-deaza-ddGTP - ATTO-633, a fluorescent nucleotide analog, is a product of great importance in biomedical research, specializing in studying DNA replication and repair mechanisms. Its usage is specifically geared towards single-molecule fluorescence-based assays in analyzing the behaviors of DNA polymerases and helicases. Enabling the detection of DNA damage-related diseases like cancer, this product is ideal due to its unique fluorescence properties. Synonyms: 7-Deaza-7-propargylamino-2',3'-dideoxyguanosine-5'-triphosphate, labeled with ATTO 633, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C14H20N5O12P3- ATTO 633 (free acid). Mole weight: 1076.26 (free acid). | |
Amenamevir Quick inquiry Where to buy Suppliers range | Amenamevir is a DNA helicase-primase inhibitors. It has anti-HSV activity against herpes simplex keratitis. In Mar 2016, Mahuro completed a phase III trial in Herpes simplex virus infections in Japan. Uses: Herpes simplex virus infections; herpes zoster. Synonyms: UNII-94X46KW4AE; ASP2151; N-(2,6-dimethylphenyl)-N-[2-[4-(1,2,4-oxadiazol-3-yl)anilino]-2-oxoethyl]-1,1-dioxothiane-4-carboxamide. Grades: 98%. CAS No. 841301-32-4. Molecular formula: C24H26N4O5S. Mole weight: 422.55. | |
BAY-57-1293 Quick inquiry Where to buy Suppliers range | BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex. Potent helicase-primase inhibitor (HPI) effective against herpes simplex virus (HSV) infections with IC50 value of 20 nM for inhibition of the replication of both HSV-1 and HSV-2 in Vero cells, and ED50 value of 0.5 mg/kg for both HSV-1 and HSV-2 in the murine lethal challenge model of disseminated herpes. Uses: For research used only. Synonyms: Pritelivir; BAY-57-1293; BAY 57-1293; BAY-57 1293; BAY 57 1293; BAY571293; AIC316; AIC 316; AIC-316. Grades: 98%. CAS No. 348086-71-5. Molecular formula: C18H18N4O3S2. Mole weight: 402.49. | |
Cyclothialidine Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces filipinensis NR 0484. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.3 μmol/L, and the reference neomycin was 1.2 μmol/L. Synonyms: Cyclothialidine A; (2S)-2-[[(5S,8R)-5-[[(2S,3R)-1-(2-amino-3-hydroxypropanoyl)-3-hydroxypyrrolidine-2-carbonyl]amino]-13,15-dihydroxy-16-methyl-2,6-dioxo3-oxa-10-thia-7-azabicyclo[10.4.0]hexadeca-1(16),12,14-triene-8-carbonyl]amino]propanoic acid; N-[[(4R,7S)-1,3,4,5,6,7,8,10-octahydro-12,14-dihydroxy-7-[[(3R)-3-hydroxy-1-L-seryl-L-prolyl]amino]-11-methyl-6,10-dioxo-9,2,5-benzoxathiaazacyclododecin-4-yl]carbonyl]-L-alanine. CAS No. 147214-63-9. Molecular formula: C26H35N5O12S. Mole weight: 641.65. | |
Cyclothialidine B Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces sp. NR 0659. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.7 μmol/L, and the reference neomycin was 1.2 μmol/L. CAS No. 194276-76-1. Molecular formula: C25H33N5O11S. Mole weight: 611.62. | |
Cyclothialidine C Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces sp. NR 0659. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.7 μmol/L, and the reference neomycin was 1.2 μmol/L. CAS No. 161161-54-2. Molecular formula: C26H35N5O11S. Mole weight: 625.66. | |
Cyclothialidine D Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces sp. NR 0659. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.7 μmol/L, and the reference neomycin was 1.2 μmol/L. CAS No. 194276-78-3. Molecular formula: C24H31N5O11S. Mole weight: 597.60. | |
Cyclothialidine E Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces sp. NR 0659. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.7 μmol/L, and the reference neomycin was 1.2 μmol/L. CAS No. 194276-79-4. Molecular formula: C25H33N5O11S. Mole weight: 611.63. | |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 (502-513) Quick inquiry Where to buy Suppliers range | Probable ATP-dependent RNA helicase DDX53. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-123. | |
EDA-ATPγS - ATTO-495 Quick inquiry Where to buy Suppliers range | EDA-ATPγS - ATTO-495, a fluorescent substrate, finds utility in intermolecular crosslinking studies and biomedicine for detecting binding patterns of cytoskeletal motors, ATPases, and DNA helicases. Its versatile applications include neurological disorder investigation, notably Alzheimer's disease and Parkinson's disease. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-adenosine-5'-(γ-thio)-triphosphate, labeled with ATTO 495, Triethylammonium salt. Grades: ≥ 90 % by HPLC, contains approx. 5 % EDA-ADP-dye. Molecular formula: C34H45N10O14P3S (free acid). Mole weight: 942.77 (free acid). | |
EDA-GTP - 5-FAM Quick inquiry Where to buy Suppliers range | EDA-GTP - 5-FAM is a fluorescently-labeled nucleotide analog widely used in biomedical field for studying DNA synthesis, repair and replication processes. It serves as a suitable substrate for DNA polymerases and helicases, enabling the visualization and analysis of nucleotide incorporation and DNA synthesis dynamics. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-triphosphate, labeled with 5 FAM, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C34H32N7O21P3(free acid). Mole weight: 967.28 (free acid). | |
γ-[(8-Aminooctyl)-imido]-XTP Quick inquiry Where to buy Suppliers range | γ-[(8-Aminooctyl)-imido]-XTP, a biochemical reagent utilized for studying enzymes involved in RNA synthesis and processing, mimics ATP's structure and has demonstrated compatibility as a substrate for RNA polymerases. This versatile compound enables research on ribonucleases and ATP-dependent RNA helicases. Moreover, its utility extends to the study of the HIV-1 reverse transcriptase enzyme. Synonyms: γ-[(8-Aminooctyl)-imido]-xanthosine-5'-triphosphate. Grades: ≥ 95 % by HPLC. Molecular formula: C18H33N6O14P3(free acid). Mole weight: 650.41 (free acid). | |
Heliquinomycin Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces sp. MJ929-SF2. It has anti-DNA helicase activity with Ki value of 6.8 X 10-6 mol/L. It has strong anti-gram-positive bacteria (including MR-SA) activity (MIC is 0.05-0.39 μg/mL), but has no effect on gram-negative bacteria and fungi. It has anti-tumor activity on HeLa S3, L1210, IMC, B16 and FS-3 cells with IC50 (μg/mL) of 1.6, 0.97, 1.56, 0.88 and 0.83, respectively. Its acute toxicity is low, LD50 is 100 mg/kg (mouse, enterocoelia). Synonyms: NSC 702208; Rubymycin. Grades: >95%. CAS No. 178182-49-5. Molecular formula: C33H30O17. Mole weight: 698.58. | |
Heliquinomycin (Rubymycin, NSC 702208) Quick inquiry Where to buy Suppliers range | Antibiotic. DNA helicase inhibitor. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex. Topoisomerase I and II inhibitor (weaker than DNA helicase). DNA and RNA synthesis inhibitor in cell culture. Does not inhibit protein synthesis. Induces cell cycle arrest. Anticancer compound. Antibacterial against Gram-positive bacteria. Group: Biochemicals. Grades: Purified. CAS No. 178182-49-5. Pack Sizes: 250ug, 500ug. Molecular Formula: C33H30O17. US Biological Life Sciences. | Worldwide |
KIAA0809 protein, partial (881-890) Quick inquiry Where to buy Suppliers range | Helicase ARIP4. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-113. | |
Mant-dATP Quick inquiry Where to buy Suppliers range | Mant-dATP is a vital tool acting as a modified form of deoxyadenosine triphosphate (dATP) labeled with the mant fluorophore. Mant-dATP is beneficial for studying various enzymatic activities, including DNA polymerases, DNA ligases and helicases, due to its ability to monitor nucleotide incorporation during DNA synthesis. Additionally, it plays a crucial role in investigating diseases related to DNA replication and repair mechanisms. Synonyms: 3'-O-(N-Methyl-anthraniloyl)-2'-deoxyadenosine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. CAS No. 128113-53-1. Molecular formula: C18H23N6O13P3(free acid). Mole weight: 624.33 (free acid). | |
ML216 Quick inquiry Where to buy Suppliers range | Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom's Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells. Synonyms: ML 216; ML-216; CID-49852229; CID49852229; CID 49852229. Grades: >98%. CAS No. 1430213-30-1. Molecular formula: C15H9F4N5OS. Mole weight: 383.32. | |
N4-DMF-5-TFA-aha-dC Quick inquiry Where to buy Suppliers range | N4-DMF-5-TFA-aha-dC, a modified nucleoside, boasts important clinical applications as an innovative technique in the biomedical research of DNA damage and repair mechanisms. It is highly sought after by oligonucleotide scholars who utilize its powerful capabilities in examining the effects of DNA adducts on DNA polymerases and helicases. Furthermore, the advantages of incorporating N4-DMF-5-TFA-aha-dC in targeted cancer therapy development cannot be discounted as it combats malignant mutations arising from DNA damage response pathways. Synonyms: 2'-Deoxy-N-[(dimethylamino)methylene]-5-[(1E)-3-oxo-3-({6-[(trifluoroacetyl)amino]hexyl}amino)-1-propen-1-yl]cytidine; Cytidine, 2'-deoxy-N-[(dimethylamino)methylene]-5-[(1E)-3-oxo-3-[[6-[(2,2,2-trifluoroacetyl)amino]hexyl]amino]-1-propen-1-yl]-. Grades: ≥97% by HPLC. Molecular formula: C23H33F3N6O6. Mole weight: 546.54. | |
N6-(6-Amino)hexyl-dATP - 5-FAM Quick inquiry Where to buy Suppliers range | N6-(6-Amino)hexyl-dATP - 5-FAM, a fluorescently labeled nucleotide analog, finds its remarkable applicability in molecular biology for DNA synthesis, repair, and replication studies. One can efficiently detect polymerases, nicking enzymes, DNA ligases, and helicases, besides employing it in real-time PCR (polymerase chain reaction) and DNA sequencing. Remarkably, it can serve as a facile substrate for DNA polymerases in DNA synthesis reactions, making it a versatile compound paving new avenues for intriguing scientific pursuits. Synonyms: N; -(6-Amino)hexyl-2'-deoxyadenosine-5'-triphosphate, labeled with 5 FAM, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C37H39N6O18P3(free acid). Mole weight: 948.66 (free acid). | |
Norfloxacin Quick inquiry Where to buy Suppliers range | Norfloxacin and ofloxacin, levofloxacin, ciprofloxacin belong to the third generation fluoroquinolone antibacterial drugs, with a broad spectrum of antibacterial action, especially against aerobic gram-negative bacteria with high antibacterial activity, against the following bacteria in vitro has a good antibacterial effect: Most of the bacteria in the Enterobacteriaceae family, including E. coli, Enterobacter cloacae, Enterobacter aerogenes, E. coli, Klebsiella, Chemicalbook Proteus, Salmonella, Shigella, Vibrio, Yersinia, etc. Norfloxacin also has antibacterial activity against multi-drug resistant bacteria in vitro. The penicillin-resistant Neisseria gonorrhoeae, Haemophilus influenzae and Moraxella catarrh also have good antibacterial effects. Norfloxacin is A bactericide that causes bacterial death by inhibiting DNA synthesis and replication by acting on the A subunit of bacterial DNA helicase. Uses: Used for research and manufacturing. Group: Antibacterial, Anti-inflammatory and Antiviral Series. Grades: CEP/ISO. Approvals: USP. CAS No. 70458-96-7. Product ID: PAP-0063. Appearance: Crystalline Powder. | |
NSC 617145 Quick inquiry Where to buy Suppliers range | NSC 617145 is a werner syndrome helicase inhibitor with IC50 value of 250 nM. It is used as an antineoplastic. Synonyms: 1,1'-(2,2-dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-Pyrrole-2,5-dione. Grades: ≥98% by HPLC. CAS No. 203115-63-3. Molecular formula: C13H10Cl4N2O4. Mole weight: 400.04. | |
PHA 767491 Dihydrochloride Salt Quick inquiry Where to buy Suppliers range | A potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2). Group: Biochemicals. Alternative Names: 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one Dihydrochloride;PHA 767491 Dihydrochloride Salt; PF-02334471. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Sennidin B Quick inquiry Where to buy Suppliers range | Sennidin B, a stereoisomer isolated from the leaves of Cassia angustifolia, has lower activity than Sennidin A. Sennidin A inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation. Group: Biobased Products. Alternative Names: 9-(2-Carboxy-4,5-dihydroxy-10-oxo-9H-anthracen-9-yl)-4,5-dihydroxy-10-oxo-9H-anthracene-2-carboxylic acid. Grades: 98%. CAS No. 517-44-2. Product ID: BBC517442. Molecular formula: C30H18O10. Mole weight: 538.46. IUPAC Name: (9S)-9-[(9R)-2-carboxy-4,5-dihydroxy-10-oxo-9H-anthracen-9-yl]-4,5-dihydroxy-10-oxo-9H-anthracene-2-carboxylic acid. Appearance: Powder. Density: 1.695±0.06 g/ml. SMILES: C1=CC2=C (C (=C1)O)C (=O)C3=C ([C@@H]2[C@H]4C5=C (C (=CC=C5)O)C (=O)C6=C4C=C (C=C6O)C (=O)O)C=C (C=C3O)C (=O)O. | |
(S)-(+)-Ochracin Quick inquiry Where to buy Suppliers range | (S)-(+)-ochracin is a marine derived natural products found in Helicascus kanaloanus. Group: Marine Chemicals. Alternative Names: Mellein. Grades: 95%+. CAS No. 1200-93-7. Product ID: ACM1200937. Mole weight: 178.18. IUPAC Name: 8-Hydroxy-3-methyl-3,4-dihydroisochromen-1-one. Density: 1.252±0.06 g/cm³. SMILES: CC1CC2=C(C(=CC=C2)O)C(=O)O1. | |
Suramin Hexasodium Salt (Germanin, NSC 34936, SK 24728) Quick inquiry Where to buy Suppliers range | Sodium salt of Suramin, a hepatitis C virus NS3 helicase inhibitor. Also used in the treatment of arthritis due to problematic collagen.A P2x and P2y purinergic receptor antagonist that displays antitumor, antiangiogenic and antiparasitic activities. Inhibits sirtuin 1, sirtuin 5 and topoisomerase II. Inhibits the cell surface binding of various growth factors including PDGF, EGF, FGFa and FGFb. Blocks association of G protein alpha and b/g-subunits. Potent competitive inhibitor of reverse transcriptase and protects T lymphocytes against in vitro human immunodeficiency virus infection.Potent ATPase inhibitor. Potent competitive inhibitor of reverse transcriptase. Shows anti-HIV activity. Anticancer compound. Protein kinase C (PKC) inhibitor. Potent inhibitor of melanoma heparanase and tumor cell metastasis. Non-specific growth factors inhibitor (including PDGF, EGF, aFGF and bFGF). TGF-beta1 inhibitor. Topoisomerase I and II inhibitor. Interleukin-1 (IL-1) inhibitor. Interleukin-4 (IL-4) inhibitor. G protein inhibitor. P2X and P2Y purinergic receptor antagonist. Antiangiogenic. Potent VEGF inhibitor. Telomerase inhibitor. Shows adjuvant properties. Regulates ryanodine receptor. Direct adenylyl cyclase inhibitor. Protein synthesis inhibitor. SIRT1 (Sirtuin 1) and SIRT5 (Sirtuin 5) inhibitor. Immunosuppressive. Antifibrotic agent. Antiparasitic. Antiprotozoal. Athelmintic. Group: Biochemicals. Alternative Names: 8, 8'-[Carbonylbis[imino-3, 1-phenylenecarbonylimino (4-methyl-3, 1-phenylene) carbonylimino]]bis-1, 3, 5-naphthalenetrisulfonic Acid Sodium Salt (1:6); 8, 8'-[Carbonylbis[imino-3, 1-phenylenecarbonylimino (4-methyl-3, 1-phenylene) carbonylimino]]bis-1, 3, 5-naphthalenetrisulfonic Acid Hexasodium Salt; 8, 8'-[Ureylenebis[m-phenylenecarbonylimino (4-methyl-m-phenylene) carbonylimino]]di-1, 3, 5-naphthalenetrisulfonic Acid Hexasodium Salt; 309F; 8,8'-[Ureylenebis[m-phenylene carbonylimino (4-methyl-m-phenylene) carbonylimino]]di (1, 3, 5-naphthalenetrisulfonic Acid) Hexasodium Salt; Antrypol; BAY 205; Bayer 205; CI 1003; Fourneau 309; Germanin; Germanin (pharmaceutical); Hexasodium Sym.-bis(m-aminobenzoyl)-m-amino-p-methylbenzoyl-1-naphthylamino-4,6,8-trisulfonate) Carbamide; Moranyl; NF 060; Naganin; Naganine; Naphuride; Naphuride sodium; Sodium Suramin; Suramin Hexasodium; Suramin Sodium; Suramine Sodium. Grades: Highly Purified. CAS No. 129-46-4. Pack Sizes: 50mg, 100mg, 250mg. Molecular Formula: C??H??N?Na?O??S?, Molecular Weight: 1429.17. US Biological Life Sciences. | Worldwide |
YK-4-279 Quick inquiry Where to buy Suppliers range | YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).YK-4-279 eliminates cyclin D levels by blocking the interaction of EWS-FLI1 with RHA in EWS-FLI1-containing TC32 cells. Synonyms: YK-4-279; YK4-279; YK 4-279; YK-4279; YK4279; YK 4279. Grades: >98%. CAS No. 1037184-44-3. Molecular formula: C17H13Cl2NO4. Mole weight: 366.20. |