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25g Pack Size. Group: Bioactive Small Molecules, Building Blocks, Diagnostic Raw Materials, Research Organics & Inorganics. Formula: C5H9N3 · 2HCl. CAS No. 56-92-8. Prepack ID 19012772-25g. Molecular Weight 184.07. See USA prepack pricing.
Histaminedihydrochloride
Histaminedihydrochloride is a histamine salt used to prevent relapse in patients with acute myeloid leukemia (AML). It is also used as an active ingredient in topical analgesia for temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, bruises, sprains and strains. Uses: Present in most mammalian tissues; primarily stored in mast cells and basophils. exhibits multiple biological effects through at least 3 specific receptors. induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter. histamine has been identified as a bedbug pheromone. Synonyms: 1H-Imidazole-4-ethanamine Dihydrochloride; 2-(1H-Imidazol-4-yl)ethanamine Dihydrochloride; 2-(1H-Imidazol-4-yl)ethylamine Dihydrochloride; 4-(2-Aminoethyl)imidazole Dihydrochloride; Ceplene; Peremin; 2-(1H-imidazol-4-yl)ethan-1-amine dihydrochloride. Grades: >98%. CAS No. 56-92-8. Molecular formula: C5H9N3.2HCl. Mole weight: 184.07.
Histaminedihydrochloride
Histaminedihydrochloride is a reactive oxygen species ( ROS ) inhibitor. Histaminedihydrochloride can suppress ROS production and work together with IL-2 to activate T cells and NK cells, leading to immune activation in the tumor microenvironment, which consequently kills acute myeloid leukemia (AML) cells. Histaminedihydrochloride can cause a reduction in vaginal tetrazo reduction, increased epithelial growth, and heightened keratinization in mouse models of ovariectomy. Histaminedihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 56-92-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-B0722.
HistamineDihydrochloride
Histaminedihydrochloride (INN, trade name Ceplene) is a salt of histamine which is used as a drug for the prevention of relapse in patients diagnosed with acute myeloid leukemia (AML).It is an FDA approved active ingredient for topical analgesic use and is available in such products as Australian Dream Cream, which is used for the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, bruises, sprains, and strains. Uses: Present in most mammalian tissues; primarily stored in mast cells and basophils. exhibits multiple biological effects through at least 3 specific receptors. induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter. histamine has been identified as a bedbug pheromone. Group: Other alkaloids. Alternative Names: 2-(3H-Imidazol-4-yl)ethanamine dihydrochloride. CAS No. 56-92-8. Molecular formula: C5H11Cl2N3. Mole weight: 184.07. Appearance: White to off-white solid. Purity: 0.98. IUPACName: 2-(1H-imidazol-5-yl)ethanamine;dihydrochloride. Canonical SMILES: C1=C(NC=N1)CCN.Cl.Cl. Density: 1.14 g/cm³. Catalog: ACM56928.
HistamineDihydrochloride
Present in most mammalian tissues; primarily stored in mast cells and basophils. Exhibits multiple biological effects through at least 3 specific receptors. Induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter. Group: Biochemicals. Alternative Names: 1H-Imidazole-4-ethanamine Dihydrochloride; 2-(1H-Imidazol-4-yl)ethanamine Dihydrochloride; 2-(1H-Imidazol-4-yl)ethylamine Dihydrochloride; 4-(2-Aminoethyl)imidazole Dihydrochloride; Ceplene; Histamine Chloride; Histamine Dichloride; Histamine Hydrochloride; Histaminediium Dichloride; Peremin. Grades: Highly Purified. CAS No. 56-92-8. Pack Sizes: 100g, 250g. Molecular Formula: C5H9N3·2HCl, Molecular Weight: 184.07. US Biological Life Sciences.
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Histaminedihydrochloride salt 98+% (TLC)
Histaminedihydrochloride salt 98+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100g, 250g, 25g, 1Kg. US Biological Life Sciences.
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1-Methylhistaminedihydrochloride
1-Methylhistaminedihydrochloride is a histamine metabolite [1]. Uses: Scientific research. Group: Natural products. CAS No. 6481-48-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W053787.
3-Methyl histaminedihydrochloride
3-Methyl histaminedihydrochloride. Group: Biochemicals. Alternative Names: 1-Methyl-1H-imidazole-5-ethanamine dihydrochloride. Grades: Highly Purified. CAS No. 36475-47-5. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C6H13Cl2N3. US Biological Life Sciences.
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3-Methylhistaminedihydrochloride
3-Methylhistaminedihydrochloride is a degradation product of histamine. 3-Methylhistaminedihydrochloride, a methylated product of histamine, is associated with immune response and shows upregulation in the vaccinated mice [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 36475-47-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113412A.
4-Methyl histaminedihydrochloride
4-Methyl histaminedihydrochloride. Group: Biochemicals. Alternative Names: 4-Methyl-1H-imidazole-5-ethanamine. Grades: Highly Purified. CAS No. 36376-47-3. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C6H13Cl2N3. US Biological Life Sciences.
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4-Methylhistaminedihydrochloride
4-Methylhistaminedihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes. Intratracheal administration of 4 methylhistamine (10 μg/animal) reduces airway resistance and inflammation and increases the number of CD4+CD25+FoxP3+ regulatory T cells in a mouse model of allergic asthma. Synonyms: 5-(2-Aminoethyl)-4-methylimidazole dihydrochloride; 5-Methyl-1H-imidazole-4-ethanamine Hydrochloride; 2-(5-Methyl-4-imidazolyl)ethylamine Dihydrochloride; 4-(2-Aminoethyl)-5-methylimidazole Dihydrochloride; 5-MethylhistamineDihydrochloride; 5(4)-MethylhistamineDihydrochloride; 5-(2-Aminoethyl)-4- methylimidazole Dihydrochloride. CAS No. 36376-47-3. Molecular formula: C6H11N3.2HCl. Mole weight: 198.09.
4-Methylhistaminedihydrochloride
4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor ( H4R ). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 36376-47-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-107560.
Present in mo. Group: Biochemicals. Alternative Names: 1-H-Imidazole-4-ethanamine-d4; 5-Imidazole-ethylamine-d4;b-Aminoethylimidazole-d4; Maxamine-d4. Grades: Highly Purified. CAS No. 344299-48-5. Pack Sizes: 1mg. US Biological Life Sciences.
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Histamine-α,α,β,β-d4 dihydrochloride
Histamine-α, α, β, β-d 4 (dihydrochloride) is the deuterium labeled Histamine. Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Ergamine-α,α,β,β-d4 (dihydrochloride). CAS No. 344299-48-5. Pack Sizes: 5 mg. Product ID: HY-B1204S.
Nα-Methylhistaminedihydrochloride
Nα-Methylhistaminedihydrochloride, a production of Nα-Methylhistamine (NAMH), is a potent histamine agonist, particularly at H3 receptors (potency relative to histamine is 81, 185, and 270% at H1, H2 and H3 respectively). Nα-Methylhistamine is a potent H2R agonist as well as a H3R agonist. Synonyms: N-Methyl-1H-imidazole-4-ethanamine dihydrochloride; 2-(1H-Imidazol-5-yl)-N-methylethanamine Dihydrochloride; 4-[2-(Methylamino)ethyl]-imidazole Dihydrochloride; N-Methyl-1H-imidazole-4-ethanamine Dihydrochloride; NAMH dihydrochloride. CAS No. 16503-22-3. Molecular formula: C6H11N3.2HCl. Mole weight: 198.09.
R(-)-a-Chloromethyl histaminedihydrochloride
R(-)-a-Chloromethyl histaminedihydrochloride. Group: Biochemicals. Alternative Names: a-(Chloromethyl)-1H-imidazole-4-ethanamine dihydrochloride. Grades: Highly Purified. CAS No. 75614-86-7. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C6H12Cl3N3. US Biological Life Sciences.
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R(-)-α-Chloromethyl HistamineDihydrochloride
Histamine analog, with histamine-like activity. Group: Biochemicals. Alternative Names: α-(Chloromethyl)-1H-imidazole-4-ethanamine Dihydrochloride. Grades: Highly Purified. CAS No. 75614-86-7. Pack Sizes: 500mg. US Biological Life Sciences.
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(R)-(-)-α-Methylhistaminedihydrochloride
(R)-(-)-α-Methylhistaminedihydrochloride is a potent, selective and brain-penetrant agonist of H3 histamine receptor, with a K d of 50.3 nM [1] [2]. (R)-(-)-α-Methylhistaminedihydrochloride can enhance memory retention, attenuates memory impairment in rats [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 75614-89-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W014941.
R(-)-α-Methyl HistamineDihydrochloride
Potent, selective H3 histamine receptor agonist which crosses the blood-brain barrier; inhibits histamine synthesis and release. Group: Biochemicals. Alternative Names: (αR)-. Grades: Highly Purified. CAS No. 75614-89-0. Pack Sizes: 100mg. US Biological Life Sciences.
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2-(3-Pyrazolyl)ethanamine Dihydrochloride
Betazole hydrochloride is a histamine H2 agonist used clinically to test gastric secretory function. Synonyms: 2-(1H-pyrazol-5-yl)ethanamine;dihydrochloride; 2-(1H-pyrazol-5-yl)ethanamine;dihydrochloride. Grades: ≥ 98 %. CAS No. 138-92-1. Molecular formula: C5H11Cl2N3. Mole weight: 184.07.
[2- [4- [ (4-Chlorophenyl) phenylmethyl] -1-piperazinyl] ethoxy] acetyl Chloride Dihydrochloride is an intermediate in the synthesis of Cetirizine (C291155), an nonsedating type histamine H1-receptor antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 324047-28-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C21H24Cl2N2O2. US Biological Life Sciences.
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2-Pyridylethylamine dihydrochloride
2-Pyridylethylamine dihydrochloride is a histamine H1 receptor agonist that produces vasoconstriction. Synonyms: 2-Pyridineethanamine, hydrochloride (1:2); 2-Pyridineethanamine, dihydrochloride; Pyridine, 2-(2-aminoethyl)-, dihydrochloride; 2-(2-Aminoethyl)pyridine dihydrochloride; 2-(2-Pyridyl)ethylamine dihydrochloride; 2-(Pyridin-2-yl)ethanamine dihydrochloride; 2-(β-Aminoethyl)pyridine dihydrochloride; 2-Pyridylethylamine hydrochloride. Grades: ≥99% by HPLC. CAS No. 3343-39-3. Molecular formula: C7H10N2.2HCl. Mole weight: 195.09.
3-Hydroxy Desloratadine Dihydrochloride Hydrate
3-Hydroxy Desloratadine Dihydrochloride Hydrate is one of loratadine metabolites. Loratadine is a nonsedating-type histamine H1-receptor antagonist used to treat allergies. Synonyms: 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol Dihydrochloride Hydrate; 3-Hydroxydesloratadine Dihydrochloride Hydrate; Sch 45581 Dihydrochloride Hydrate. Molecular formula: C19H23Cl3N2O2. Mole weight: 417.76.
A 331440 dihydrochloride
A 331440 dihydrochloride is a histamine H3 receptor antagonist (Ki = 21.7 and 22.7 nM for rat and human H3 receptors, respectively). A 331440 reduces weight in a diet-induced obesity model. Synonyms: A-331440 dihydrochloride; A 331440 dihydrochloride; A331440 dihydrochloride; 4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1049740-32-0. Molecular formula: C22H27N3O.2HCl. Mole weight: 422.39.
A 943931 dihydrochloride
A 943931 dihydrochloride is a potent and selective histamine H4 receptor antagonist (pKi = 7.15 and 8.12 at human and rat receptors, respectively). A 943931 blocks inflammation in a peritonitis mouse model and displays efficacy in inflammatory pain and neuropathic pain models. Synonyms: A 943931 dihydrochloride; A943931 dihydrochloride; A-943931 dihydrochloride; 4-((3R)-3-amino-pyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine. Grades: ≥98% by HPLC. CAS No. 1227675-50-4. Molecular formula: C17H21N5.2HCl. Mole weight: 368.31.
Amodiaquin dihydrochloride dihydrate
Amodiaquine, a 4-aminoquinoquinoline compound, is a histamine N-methyltransferase inhibitor, used as an antimalarial and anti-inflammatory agent for more than 40 years. Uses: Antimalarial. Synonyms: AMODIAQUIN DIHYDROCHLORIDE; amodiaquin dihydrochloride dihydrate; AMODIAQUINE DIHYDROCHLORIDE; AMODIAQUINE HCL; AMODIAQUIN HYDROCHLORIDE; 4-[(7-CHLORO-4-QUINOLINYL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL DIHYDROCHLORIDE; 4-([7-chloro-4-quinolinyl]amino)-2-([diet. Grades: >98%. CAS No. 6398-98-7. Molecular formula: C20H28Cl3N3O3. Mole weight: 464.81.
Amodiaquine dihydrochloride
Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor with a K i of 18.6 nM. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC 50 of ~20 μM. Anti-inflammatory effect [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Amodiaquin dihydrochloride. CAS No. 69-44-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B1322B.
Bavisant dihydrochloride hydrate
Bavisant dihydrochloride hydrate (JNJ31001074AAC) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H 3 receptor. Bavisant dihydrochloride hydrate can be used for attention-deficit hyperactivity disorder (ADHD) research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNJ31001074AAC; JNJ31001074 dihydrochloride hydrate. CAS No. 1103522-80-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14880B.
Betahistine-d3 dihydrochloride
Betahistine-d 3 (dihydrochloride) is the deuterium labeled Betahistine dihydrochloride. Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist[1]. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA)[3]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 244094-72-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0524AS.
Betahistine dihydrochloride
Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist [1]. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA) [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5579-84-0. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-B0524A.
Betahistine dihydrochloride
Betahistine is a histamine H3 receptors inhibitor with IC50 of 1.9 μM. Synonyms: N-methyl-2-pyridin-2-ylethanamine;dihydrochloride. Grades: > 98 %. CAS No. 5579-84-0. Molecular formula: C8H12N2 · 2HCl. Mole weight: 209.12.
Carcinine dihydrochloride
Carcinine (β-Alanylhistamine) dihydrochloride is a selective histamine H3 antagonist with antioxidant activity and neuroprotective effects on the retina of oxidatively stressed mice [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: β-Alanylhistaminedihydrochloride. CAS No. 57022-38-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-107567B.
Cetirizine dihydrochloride
Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: P071. CAS No. 83881-52-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-17042A.
A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Group: Biochemicals. Alternative Names: [2- [4- [ (4-Chlorophenyl) -phenylmethyl] -1-piperazinyl] ethoxy] acetic Acid, Dihydrochloride. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
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Cetirizine Impurity C dihydrochloride
Cetirizine Impurity C dihydrochloride is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2702511-37-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-131256A.
Cetirizine Related Compound
4-Benzhydryl-1-piperazineethanol Dihydrochloride, is a building block used for the preparation of various pharmaceutical compounds. It is used for the synthesis of 25 unsymmetrical 1,4-disubstituted piperazines as histamine antagonists. Synonyms: 4-(Diphenylmethyl)-1-piperazineethanol Hydrochloride (1:2). Grades: > 95%. CAS No. 108983-83-1. Molecular formula: C19H24N2O.2HCl. Mole weight: 369.3.
Clozapine hydrochloride
Clozapine (HF 1854) is an antipsychotic used to treat schizophrenia. Clozapine is a potent antagonist of dopamine and a number of other receptors. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor. Clozapine is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It also binds to the 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 receptors, as well as the histamine H1 and α1-adrenergic receptors. Synonyms: 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride; HF 1854 dihydrochloride. Grades: ≥98%. Molecular formula: C18H19ClN4·2HCl. Mole weight: 399.74.
Cyclizine Dihydrochloride
Cyclizine 2HCl is a piperazine derivative with Histamine H1 receptor antagonist activity. Synonyms: Cyclizine 2HCl; Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride. Grades: >98%. CAS No. 5897-18-7. Molecular formula: C18H24Cl2N2. Mole weight: 339.30.
Cyproheptadine hydrochloride sesquihydrate
Cyproheptadine is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. Cyproheptadine is a 5-HT2/5-HT1C serotonin receptor antagonist; H1 histamine receptor antagonist; antipruritic. Uses: Anti-allergic agents. Synonyms: 1-methyl-4-(2-tricyclo[9.4.0.03, 8]pentadeca-1(15), 3, 5, 7, 9, 11, 13-heptaenylidene)piperidine; trihydrate; dihydrochloride. Grades: > 95 %. CAS No. 41354-29-4. Molecular formula: C21H21N · HCl · 1.5H2O. Mole weight: 350.88.
Decloxizine hydrochloride
The hydrochloride salt form of Decloxizine, a hydroxyzine analogue, is a histamine 1 receptor antagonist and often known as an impurity of Hydroxyzine. Uses: The hydrochloride salt form of decloxizine is a histamine 1 receptor antagonist and often known as an impurity of hydroxyzine. Synonyms: 2-[2-[4-(Diphenylmethyl)-1-piperazinyl]ethoxy]ethanol Hydrochloride; 1-[2-(2-Hydroxyethoxy)ethyl]-4-α-phenylbenzyldiethylenediamine Dihydrochloride; Autokar; Hydroxydiethylphenamine; Rescupal; UCB 1402; UCB1402; UCB-1402. Grades: 95%. CAS No. 13073-96-6. Molecular formula: C21H28N2O2?2ClH. Mole weight: 413.39.
Descyano Cimetidine Dihydrochloride Salt
Descyano Cimetidine Dihydrochloride Salt is a metabolite of Cimetidine. It is a competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output. Synonyms: N-Methyl-N'-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]guanidine Dihydrochloride; N-Methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]gunaidine Dihydrochloride. Grades: > 95%. CAS No. 59660-24-1. Molecular formula: C9H19Cl2N5S. Mole weight: 300.25.
Dimaprit dihydrochloride
Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC 50 of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 23256-33-9. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B1478.
Dimaprit dihydrochloride
The hydrochloride salt form of Dimaprit, which has been found to be a histamine H2 receptor agonist. Uses: Histamine agonists. Synonyms: S-(3-Dimethylaminopropyl)isothiourea dihydrochloride. Grades: ≥99% by HPLC. CAS No. 23256-33-9. Molecular formula: C6H15N3S.2HCl. Mole weight: 234.19.
EP Chlorpheniramine Maleate Impurity A (2HCl salt form)
An impurity of Chlorpheniramine. Chlorpheniramine is an antihistamine used to prevent symptoms of allergy. It acts via inhibiting histamine produced during anaphylaxis. Synonyms: 2-(4-Chlorophenyl)-4-(dimethylamino)-2-(2-(dimethylamino)ethyl)butanenitrile; 2-(4-Chlorophenyl)-4-(dimethylamino)-2-[2-(dimethylamino)ethyl]butanenitrile dihydrochloride. Grades: 95%. Molecular formula: C16H26Cl3N3. Mole weight: 366.761.
Famotidine Impurity A
An impurity of Famotidine. Famotidine is a histamine H2 receptor antagonist that inhibits stomach acid production. Synonyms: 3-[[[2-[(Diaminomethylene)amino]thiazol-4-yl]methyl]sulphanyl]propanimidamide dihydrochloride. Grades: > 95%. CAS No. 88061-72-7. Molecular formula: C8H14N6S2. Mole weight: 258.37.
Famotidine Impurity H DiHCl
An impurity of Famotidine. Famotidine is a histamine H2 receptor antagonist that inhibits stomach acid production. Synonyms: S-(2-Guanidino-4-thiazolyl)methylisothiourea Dihydrochloride. Grades: > 95%. CAS No. 88046-01-9. Molecular formula: C6H10N6S2. 2 HCl. Mole weight: 230.31 2 36.46.
Hydroxyzine dihydrochloride
Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2192-20-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0548A.
JNJ10181457
JNJ10181457 dihydrochloride is a selective non-imidazole brain penetrant histamine H3 receptor antagonist with pKi values of 8.15 and 8.93 for rat and human H3 receptors respectively. It increases acetylcholine and extracellular norepinephrine levels in rat frontal cortex, but it does not stimulate dopamine release. It normalizes acetylcholine neurotransmission and shows efficacy in translational rat models of cognition. Uses: Jnj10181457 dihydrochloride normalizes acetylcholine neurotransmission. Synonyms: JNJ-10181457; JNJ10181457; JNJ 10181457; JNJ-10181457 dihydrochloride;4-[[3-(4-piperidin-1-ylbut-1-ynyl)phenyl]methyl]morpholine dihydrochloride. Grades: >98 %. CAS No. 544707-19-9. Molecular formula: C20H28N2O. Mole weight: 312.4.
JNJ 10181457 dihydrochloride
The hydrochloride salt form of JNJ 10181457, which has been found to be a histamine H3 receptor inhibitor and could be a brain penetrant. Synonyms: JNJ 10181457 dihydrochloride; JNJ10181457 dihydrochloride; JNJ-10181457 dihydrochloride; 4-[3-[4-[Piperidinyl]but-1-ynyl]benzyl]morpholine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 544707-20-2. Molecular formula: C20H28N2O.2HCl. Mole weight: 385.37.
JNJ-39758979 dihydrochloride
JNJ-39758979 is a potent and selective histamine H4 antagonist (Ki = 12.5 nM) with >80-fold selectivity for H4 over other histamine receptors. It was shown to inhibit histamine-induced pruritus in healthy subjects. Synonyms: 4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1620648-30-7. Molecular formula: C11H19N5·2HCl. Mole weight: 294.22.
Latrepirdine dihydrochloride
Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β ( Aβ ) secretion. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dimebolin dihydrochloride. CAS No. 97657-92-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-14537.
Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (R)-Cetirizine dihydrochloride. CAS No. 130018-87-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W010841.
Meclizine dihydrochloride
Meclizine (Meclozine) dihydrochloride, an antihistamine , reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride is an effective anti-motion sickness agent. Meclizine dihydrochloride crosses the blood-brain barrier. Meclizine dihydrochloride can be used for the research of polyQ toxicity disorders, such as Huntington's disease. Meclizine dihydrochloride is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Meclozine dihydrochloride. CAS No. 1104-22-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 5 g. Product ID: HY-B0349.
Mizolastine dihydrochloride
The dihydrochloride salt form of Mizolastine which is effective in the treatment of seasonal allergic rhinitis, perennial allergic rhinitis and other allergy symptoms for playing the role as a histamine H1-receptor antagonis. IC50: 47nM. Uses: The dihydrochloride salt form of mizolastine which is effective in the treatment of seasonal allergic rhinitis, perennial allergic rhinitis and other allergy symptoms for playing the role as a histamine h1-receptor antagonis. Synonyms: Mizolastine (dihydrochloride); CS-1998. Grades: 98%. CAS No. 1056596-82-7. Molecular formula: C24H27Cl2FN6O. Mole weight: 505.42.
R-(?)-α-Methylhistamine hydrochloride
R-(-)-α-Methylhistamine is a histamine H3 receptor agonist that inhibits the synthesis and release of histamine. Synonyms: (R)-1-(1H-Imidazol-4-yl)propan-2-amine dihydrochloride. Grades: ≥95%. CAS No. 75614-89-0. Molecular formula: C6H11N3·2HCl. Mole weight: 198.1.
A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic. Group: Biochemicals. Alternative Names: 2- [2- [4- [ (R) - (4-Chlorophenyl) phenylmethyl] -1-piperazinyl] ethoxy] acetic Acid Dihydrochloride; (-)-Cetirizine Dihydrochloride; Levocetirizine Dihydrochloride. Grades: Highly Purified. CAS No. 130018-77-8. Pack Sizes: 10mg. US Biological Life Sciences.
A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic. Synonyms: (S)-[2-[4-[(4-Chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic Acid Dihydrochloride; (+)-Cetirizine Dihydrochloride; Dextrocetirizine Dihydrochloride. Grades: > 95%. CAS No. 163837-48-7. Molecular formula: C21H25ClN2O3. 2 HCl. Mole weight: 388.90 2 36.46.
(S)-Cetirizine Dihydrochloride
A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic. Group: Biochemicals. Alternative Names: (S) - [2- [4- [ (4-Chlorophenyl) -phenylmethyl] -1-piperazinyl] ethoxy] acetic Acid Dihydrochloride. Grades: Highly Purified. CAS No. 163837-48-7. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
SKF 91488 dihydrochloride
SKF 91488 dihydrochloride is a potent inhibitor of histamine N-methyltransferase with no histamine agonist activity. SKF 91488 is used in the treatment of depression, anxiety and Parkinson's disease. Uses: The treatment of depression, anxiety and parkinson's disease. Synonyms: SKF 91488 dihydrochloride; SKF91488 dihydrochloride; SKF-91488 dihydrochloride; 4-(N,N-Dimethylamino)butylisothiourea dihydrochloride. CAS No. 68941-21-9. Molecular formula: C7H17N3S.2HCl. Mole weight: 248.21.
SKF 91488 dihydrochloride
SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a K i value of 0.9 microM. SKF 91488 dihydrochloride inhibits the methylation of labeled histamine in mice [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Homodimaprit dihydrochloride. CAS No. 68941-21-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100967.
SUVN-G3031 hydrochloride
SUVN-G3031 is a Histamine H3 receptor antagonist originated by Suven Life Sciences. Blockade of Histamine H3 receptor can augment the pre-synaptic release of both histamine and other neurotransmitters including acetylcholine from cholinergic neurons. In Aug 2016, Suven Life Sciences initiated a phase I pharmacokinetics trial for treatment of Cognition disorders in Healthy volunteers in USA. Uses: Cognition disorders. Synonyms: N-[4-(1-cyclobutyl piperidin-4-yloxy)-phenyl]-2-(morpholin-4-yl) acet amide dihydrochloride;1394808-82-2 (free base). Grades: 98%. CAS No. 1394808-20-8. Molecular formula: C21H33Cl2N3O3. Mole weight: 446,41.
Zaltidine
Zaltidine dihydrochloride (CP-5736 dihydrochloride) is a highly specific H2 receptor antagonist with antisecretion activity. Zaltidine dihydrochloride reduces the stimulant effect of histamine on gastric acid secretion by binding to histamine H2 receptors on gastric parietal cells, thus reducing gastric acid production. Zaltidine dihydrochloride can be used in the study of gastric acid-related diseases such as duodenal ulcers [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP-57361. CAS No. 85604-00-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15541.
Zuclopenthixol dihydrochloride
Zuclopenthixol dihydrochloride is an antagonist at D1 and D2 dopamine receptors. Zuclopenthixol also has high affinity for alpha1-adrenergic and 5-HT2 receptors, but it has weaker histamine H1 receptor blocking activity, and even lower affinity for muscarinic cholinergic and alpha2-adrenergic receptors. lt is the cis-isomer of clopenthixol. It is an antipsychotic drug belonging the thioxanthene class. Synonyms: Zuclopenthixol hydrochloride; Clopenthixol cis(Z)-form dihydrochloride. CAS No. 58045-23-1. Molecular formula: C22H27Cl3N2OS. Mole weight: 473.89.
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