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Indolin-2-one. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2H-Indol-2-one,1,3-dihydro-; 2-Indolinone(7CI,8CI); Oxindole (6CI); 1,3-Dihydro-2H-indol-2-one; 1,3-Dihydroindol-2-one; 2-Indolone; 2-Oxindole; 2-Oxo-2,3-dihydroindole; 2-Oxoindole; 2-Oxoindoline; Indol-2(3H)-one; NSC 274863; Oxindol. Product Category: Indoles. Appearance: Off-white crystalline powder. CAS No. 59-48-3. Molecular formula: C8H7NO. Mole weight: 133.15. Density: 1.327 g/cm³. Product ID: ACM59483. Alfa Chemistry ISO 9001:2015 Certified. Categories: Indolin-2-one monooxygenase.
indolin-2-one monooxygenase
The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses). It is a member of the cytochrome P-450 dependent monooxygenases. Group: Enzymes. Synonyms: BX3 (gene name); CYP71C2 (gene name). Enzyme Commission Number: EC 1.14.13.138. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0737; indolin-2-one monooxygenase; EC 1.14.13.138; BX3 (gene name); CYP71C2 (gene name). Cat No: EXWM-0737.
1-(2,3,5,6-Tetrafluorophenyl)indolin-2-one
1-(2,3,5,6-Tetrafluorophenyl)indolin-2-one is an impurity of Robenacoxib, a nonsteroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation in cats and dogs. Synonyms: 2H-Indol-2-one, 1,3-dihydro-1-(2,3,5,6-tetrafluorophenyl); 1,3-Dihydro-1-(2,3,5,6-tetrafluorophenyl)-2H-indol-2-one. CAS No. 2192217-93-7. Molecular formula: C14H7F4NO. Mole weight: 281.21.
3-((3-Chlorophenyl)imino)indolin-2-one
3-((3-Chlorophenyl)imino)indolin-2-one. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-((3-CHLOROPHENYL)IMINO)INDOLIN-2-ONE;SALOR-INT L173541-1EA;TIMTEC-BB SBB000955;3-((3-CHLOROPHENYL)IMINO)-1,3-DIHYDRO-2H-INDOL-2-ONE. Product Category: Heterocyclic Organic Compound. CAS No. 42407-90-9. Molecular formula: C14H9ClN2O. Mole weight: 256.69. Product ID: ACM42407909. Alfa Chemistry ISO 9001:2015 Certified.
3-hydroxy-3-(trifluoromethyl)indolin-2-one
3-hydroxy-3-(trifluoromethyl)indolin-2-one. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-hydroxy-3-(trifluoromethyl)indolin-2-one. Product Category: Heterocyclic Organic Compound. CAS No. 98294-08-7. Molecular formula: C9H6F3NO2. Mole weight: 217.145. Purity: 0.96. IUPACName: 3-hydroxy-3-(trifluoromethyl)-1H-indol-2-one. Canonical SMILES: C1=CC=C2C(=C1)C(C(=O)N2)(C(F)(F)F)O. Product ID: ACM98294087. Alfa Chemistry ISO 9001:2015 Certified.
7-(4-Bromobenzoyl)indolin-2-one. Uses: Designed for use in research and industrial production. Product Category: Bromine Series. CAS No. 91713-91-6. Molecular formula: C15H10BrNO2. Mole weight: 316.15. Product ID: ACM91713916. Alfa Chemistry ISO 9001:2015 Certified.
An impurity of Ropinirole. Ropinirole acts as a D2, D3 and D4 dopamine receptor agonist with highest affinity for D2. It is weakly active at the 5-HT2 and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, mAChRs, α1 and β-adrenoreceptors. Uses: A metabolite of ropinirole. Synonyms: 4-(2-(Propylamino)ethyl)indolin-2-one; 1,3-Dihydro-4-[2-(propylamino)ethyl]-2H-indol-2-one; Monopropyl ropinirole. Grade: > 95%. CAS No. 106916-16-9. Molecular formula: C13H18N2O. Mole weight: 218.29.
2-Oxo-5-indolinesulfonyl Chloride
2-Oxo-5-indolinesulfonyl Chloride is a reactant used in the preparation of bis-indole-substituted pyridines and piperazinediones derivatives with potential antitumor activity. Also used in the preparation of antitumor 3,5-substituted indolin-2-one derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 199328-31-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H6ClNO3S, Molecular Weight: 231.66. US Biological Life Sciences.
3-(Chloromethyl)pyridine Hydrochloride has been used as a reactant for the synthesis of (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-one derivatives as Polo-like kinase 4 (PLK4) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 6959-48-4. Pack Sizes: 2.5g, 10 g. Molecular Formula: C6H7Cl2N, Molecular Weight: 164.03. US Biological Life Sciences.
Worldwide
3-Picolyl chloride hydrochloride
3-(Chloromethyl)pyridine Hydrochloride has been used as a reactant for the synthesis of (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-one derivatives as Polo-like kinase 4 (PLK4) inhibitors. Synonyms: 3-(Chloromethyl)pyridine hydrochloride; 3-(Chloromethyl)pyridinium chloride. Grade: ≥ 98 % (HPLC). CAS No. 6959-48-4. Molecular formula: C6H6NCl·HCl. Mole weight: 164.04.
An intermediate of Ropinirole. Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2. It is weakly active at the 5-HT2, and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, mAChRs, α1, and β-adrenoreceptors. Synonyms: 4-(2-Bromoethyl)-3-chloro-1,3-dihydro-2H-indolin-2-one. Grade: 95%. CAS No. 120427-95-4. Molecular formula: C10H9BrClNO. Mole weight: 274.54.
5-Aminomethyl-1,3-dihydro-indol-2-one
5-Aminomethyl-1,3-dihydro-indol-2-one. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-(aminomethyl)-1,3-dihydro-2H-indol-2-one, 220904-92-7, AGN-PC-01NILJ, SureCN260951, AC1Q541K, CTK7E5204, MolPort-005-313-693, AKOS009235332, AG-A-81508, MCULE-6617993124, EN300-88093, 5-AMINOMETHYL-1,3-DIHYDRO-INDOL-2-ONE, 2H-Indol-2-one, 5-(aminomethyl)-1,3-dihydro-. Product Category: Heterocyclic Organic Compound. CAS No. 220904-92-7. Molecular formula: C9H10N2O. Mole weight: 162.1908. Purity: 0.97. IUPACName: 5-(aminomethyl)-1,3-dihydroindol-2-one. Product ID: ACM220904927. Alfa Chemistry ISO 9001:2015 Certified. Categories: 5-(Aminomethyl)indolin-2-one.
5-Ethyl-1,3-dihydro-1-(2,3,5,6-tetrafluorophenyl)-2H-indol-2-one is an impurity of Robenacoxib, a nonsteroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation in cats and dogs. Synonyms: N-(2,3,5,6-tetrafluorophenyl)-5-ethyloxindole; 5-Ethyl-1-(2,3,5,6-tetrafluorophenyl)indolin-2-one. CAS No. 220991-61-7. Molecular formula: C16H11F4NO. Mole weight: 309.26.
Aceclofenac EP Impurity I
Aceclofenac EP Impurity I. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1-(2,6-dichlorophenyl)indolin-2-one. CAS No. 15362-40-0. Molecular formula: C14H9Cl2NO. Mole weight: 278.13. Catalog: APB15362400.
APIO-EE-07
APIO-EE-07 is a dual-target inhibitor of RSK1 and MSK2. It was shown to suppress colon cancer cell growth and anchorage-independent growth. Synonyms: 5-Fluoro-3-(4-(4-nitrophenyl)-2-oxobut-3-enylidene)indolin-2-one. Grade: 98%. CAS No. 1606160-46-6. Molecular formula: C18H11FN2O4. Mole weight: 338.29.
(±)-BMS 204352
(±)-BMS 204352 is a potassium channel opener that can be used in the study of buspirone metabolites for treating movement disorders. Synonyms: 3-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)indolin-2-one; (+/-)-BMS 204352; (+/-)-BMS204352; (+/-)-BMS-204352. Grade: 98%. CAS No. 183720-28-7. Molecular formula: C16H10ClF4NO2. Mole weight: 359.7.
CDK2 Inhibitor II
The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G2-M transition during the cell cycle. Cdk2 Inhibitor II is a potent, cell-permeable, ATP-competitive, and selective inhibitor of Cdk2. It is a 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 with IC50 of 60 nM. Synonyms: Cyclin-dependent kinase 2 Inhibitor II; SC-221409. Grade: ≥95%. CAS No. 222035-13-4. Molecular formula: C14H11BrN4O3S. Mole weight: 395.2.
CID-25014542
CID-25014542 is a Raf kinase inhibitor. Synonyms: CID-25014542; CID25014542; CID 25014542. 5-Chloro-3-(3,5-dibromo-4-hydroxybenzylidene)indolin-2-one; (3Z)-5-chloro-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-1H-indol-2-one. CAS No. 220904-99-4. Molecular formula: C15H8Br2ClNO2. Mole weight: 429.492.
CX-6258
CX-6258 is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity. Synonyms: (E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one; CX6258; CX-6258; CX 6258. CAS No. 1202916-90-2. Molecular formula: C26H24ClN3O3. Mole weight: 461.946.
Diclofenac EP Impurity A
One of the impurities of Aceclofenac, which could be used as an anti-inflammatory as well as analgesic agent. Synonyms: Diclofenac sodium EP impurity A; Diclofenac potassium EP impurity A; Diclofenac Lactam (Diclofenac Impurity A); 2H-Indol-2-one, 1-(2,6-dichlorophenyl)-1,3-dihydro-; 1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one; 2-Indolinone, 1-(2,6-dichlorophenyl)-; 1-(2,6-Dichlorophenyl)-2-indolinone; 1-(2,6-Dichlorophenyl)indolin-2-one; 1-(2,6-Dichlorophenyl)oxindole; 1-[2,6-Dichlorophenyl]-1,3-dihydroindol-2-one; Diclofenac-lactam; N-(2,6-Dichlorophenyl)-2-indolinone; NSC 621845; Aceclofenac EP Impurity I; Diclofenac USP Related Compound A; USP Diclofenac Related Compound A; N-(2,6-Dichlorophenyl)indolin-2-one. Grade: ≥95%. CAS No. 15362-40-0. Molecular formula: C14H9Cl2NO. Mole weight: 278.14.
(E/Z)-GSK-3β inhibitor 1
(E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor (IC50 = 4.9 nM) with high antidiabetic efficacy. Synonyms: 3-(2-Pyridinylmethylene)-indolin-2-one; 3-(2-Pyridinylmethylene)-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-. Grade: ≥98%. CAS No. 3367-88-2. Molecular formula: C14H10N2O. Mole weight: 222.24.
Oxindole
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Indolin-2-one. Product Category: Inhibitors. CAS No. 59-48-3. Mole weight: 133.15. Purity: 95%+. Product ID: ACM59483-1. Alfa Chemistry ISO 9001:2015 Certified.
Oxindole
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Indolinone. CAS No. 59-48-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 5 g. Product ID: HY-Y0061.
Oxindole-6-boronic acid,pinacol ester
Oxindole-6-boronic acid,pinacol ester. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 893441-85-5, Oxindole-6-boronic acid, pinacol ester, 6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)INDOLIN-2-ONE, SureCN392563, CTK8B3929, ANW-43474, AKOS015998859, MB10159, Oxindole-6-boronic acid, pinacol ester,, AK-64366, AM804508, BB 0261323, W9225, B-4821, 2-OXOINDOLINE-6-BORONIC ACID PINACOL ESTER, 6-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,3-DIHYDROINDOL-2-ONE, 6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,3-DIHYDRO-2H-INDOL-2-ONE. Product Category: Heterocyclic Organic Compound. CAS No. 893441-85-5. Molecular formula: C14H18BNO3. Mole weight: 259.1. Purity: 0.98. IUPACName: 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydroindol-2-one. Canonical SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC3=C(CC(=O)N3)C=C2. Product ID: ACM893441855. Alfa Chemistry ISO 9001:2015 Certified.
Oxindole-7-boronic acid,pinacol ester
Oxindole-7-boronic acid,pinacol ester. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Oxindole-7-boronic acid, pinacol ester, 1150271-45-6, SureCN519420, CTK8B3940, ANW-43501, AKOS016001835, Oxindole-7-boronic acid, pinacol ester,, AK101036, BB 0261336, A-5149, 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one. Product Category: Heterocyclic Organic Compound. CAS No. 1150271-45-6. Molecular formula: C14H18BNO3. Mole weight: 259.1. Purity: 0.98. IUPACName: 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydroindol-2-one. Canonical SMILES: B1(OC(C(O1)(C)C)(C)C)C2=C3C(=CC=C2)CC(=O)N3. Product ID: ACM1150271456. Alfa Chemistry ISO 9001:2015 Certified.
Ropinirole EP Impurity D
Ropinirole EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-Despropyl Ropinirole; 4-(2-(propylamino)ethyl)indolin-2-one. CAS No. 106916-16-9. Molecular formula: C13H18N2O. Mole weight: 218.14. Catalog: APB106916169.
Ropinirole Impurity 10
Ropinirole Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(2-chloroethyl)indolin-2-one. CAS No. 168476-59-3. Molecular formula: C10H10ClNO. Mole weight: 195.65. Catalog: APB168476593.
SU 5416
SU 5416. Group: Biochemicals. Alternative Names: 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one; 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydroindol-2-one; 3-[(3,5-Dimethylpyrrol-2-yl)methylene]indolin-2-one; NSC 696819; Semaxinib; Semoxind; Sugen 5416. Grades: Highly Purified. CAS No. 204005-46-9. Pack Sizes: 10mg. Molecular Formula: C15H14N2O, Molecular Weight: 238.28. US Biological Life Sciences.
Worldwide
(Z)-SU4312
(Z)-SU4312 is an inhibitor of MAO-B and NOS with IC50s of 0.2 and 19.0 μM, respectively. Synonyms: 2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-, (3Z)-; (3Z)-3-[[4-(Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-, (Z)-; (Z)-3-(4-(Dimethylamino)benzylidene)indolin-2-one; cis-SU 4312. Grade: ≥95%. CAS No. 90828-16-3. Molecular formula: C17H16N2O. Mole weight: 264.32.
Deoxyviolacein
It is a minor, more hydrophobic co-metabolite of violacein, a useful bacterial pigment. Synonyms: (3E)-3-[1,2-Dihydro-5-(1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one2H-Indol-2-one; 3-[(4E)-2-(1H-Indole-3-yl)-5-oxo-2-pyrroline-4-ylidene]indoline-2-one. Grade: >99% by HPLC. CAS No. 5839-61-2. Molecular formula: C20H13N3O2. Mole weight: 327.34.
Diclofenac EP Impurity E
Diclofenac EP Impurity E is an impurity of Diclofenac, which is a non-selective COX inhibitor used as a non-steroidal anti-inflammatory drug (NSAID). Synonyms: Diclofenac sodium EP impurity E; Diclofenac potassium EP impurity E; 1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 1,3-dihydro-; 1,3-Dihydro-2H-indol-2-one; 2-Indolinone; Oxindole; 2,3-Dihydro-1H-indol-2-one; 2-Indolone; 2-Oxindole; 2-Oxo-2,3-dihydroindole; 2-Oxoindole; 2-Oxoindoline; Indol-2(3H)-one; Indoline-2-one; NSC 274863; Oxindol. Grade: ≥95%. CAS No. 59-48-3. Molecular formula: C8H7NO. Mole weight: 133.15.
GSK-3β inhibitor 1
GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor (IC50 = 4.9 nM) with high antidiabetic efficacy. Synonyms: 3-[(Z)-(2-Pyridinyl)methylene]indoline-2-one; (3Z)-3-(2-pyridinylmethylene)-1,3-dihydro-2H-indol-2-one; (3Z)-3-(pyridin-2-ylmethylene)-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-. Grade: ≥95%. CAS No. 187325-53-7. Molecular formula: C14H10N2O. Mole weight: 222.24.