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| Product | Description | |
|---|---|---|
| 2-hydroxy-1,4-benzoquinone reductase | A flavoprotein (FMN) that differs in substrate specificity from other quinone reductases. The enzyme in Burkholderia cepacia is inducible by 2,4,5-trichlorophenoxyacetate. Group: Enzymes. Synonyms: hydroxybenzoquinone reductase; 1,2,4-trihydroxybenzene:NAD oxidoreductase. Enzyme Commission Number: EC 1.6.5.7. CAS No. 214466-94-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1596; 2-hydroxy-1,4-benzoquinone reductase; EC 1.6.5.7; 214466-94-1; hydroxybenzoquinone reductase; 1,2,4-trihydroxybenzene:NAD oxidoreductase. Cat No: EXWM-1596. |  |
| (2R)-sulfolactate sulfo-lyase | Requires iron(II). This inducible enzyme participates in cysteate degradation by the bacterium Paracoccus pantotrophus NKNCYSA and in 3-sulfolactate degradation by the bacterium Chromohalobacter salexigens. The enzyme is specific for the (R) isomer of its substrate. Group: Enzymes. Synonyms: Suy; SuyAB; 3-sulfolactate bisulfite-lyase; sulfolactate sulfo-lyase (ambigious); (2R)-3-sulfolactate bisulfite-lyase (pyruvate-forming). Enzyme Commission Number: EC 4.4.1.24. CAS No. 1256650-35-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5326; (2R)-sulfolactate sulfo-lyase; EC 4.4.1.24; 1256650-35-7; Suy; SuyAB; 3-sulfolactate bisulfite-lyase; sulfolactate sulfo-lyase (ambigious); (2R)-3-sulfolactate bisulfite-lyase (pyruvate-forming). Cat No: EXWM-5326. | |
| abieta-7,13-dien-18-al dehydrogenase | Abietic acid is the principle component of conifer resin. This enzyme catalyses the last step of the pathway of abietic acid biosynthesis in Abies grandis (grand fir). The activity has been demonstrated in cell-free stem extracts of A. grandis, was present in the cytoplasm, and required NAD+ as cofactor. The enzyme is expressed constitutively at a high level, and is not inducible by wounding of the plant tissue. Group: Enzymes. Synonyms: abietadienal dehydrogenase (ambiguous). Enzyme Commission Number: EC 1.2.1.74. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1176; abieta-7,13-dien-18-al dehydrogenase; EC 1.2.1.74; abietadienal dehydrogenase (ambiguous). Cat No: EXWM-1176. | |
| alcohol dehydrogenase (cytochrome c) | A periplasmic PQQ-containing quinoprotein. Occurs in Pseudomonas and Rhodopseudomonas. The enzyme from Pseudomonas aeruginosa uses a specific inducible cytochrome c550 as electron acceptor. Acts on a wide range of primary and secondary alcohols, but not methanol. It has a homodimeric structure [contrasting with the heterotetrameric structure of EC 1.1.2.7, methanol dehydrogenase (cytochrome c)]. It is routinely assayed with phenazine methosulfate as electron acceptor. Activity is stimulated by ammonia or amines. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ. Group: Enzymes. Synonyms: type I quinoprotein alcohol dehydrogenase; quinoprotein ethanol dehydrogenase. Enzyme Commission Number: EC 1.1.2.8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0390; alcohol dehydrogenase (cytochrome c); EC 1.1.2.8; type I quinoprotein alcohol dehydrogenase; quinoprotein ethanol dehydrogenase. Cat No: EXWM-0390. | |
| BYK 191023 dihydrochloride | BYK 191023 is a highly selective inducible nitric-oxide synthase (iNOS) inhibitor. BYK 191023 interacts with the catalytic center of the enzyme. BYK 191023 can be used to study the in vivo and in vitro effects mediated by iNOS [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216722-25-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-107584. |  |
| chlorophyllase | Chlorophyllase has been found in higher plants, diatoms, and in the green algae Chlorella. This enzyme forms part of the chlorophyll degradation pathway and is thought to take part in de-greening processes such as fruit ripening, leaf senescence and flowering, as well as in the turnover and homeostasis of chlorophyll. This enzyme acts preferentially on chlorophyll a but will also accept chlorophyll b and pheophytins as substrates. Ethylene and methyl jasmonate, which are known to accelerate senescence in many species, can enhance the activity of the hormone-inducible form of this enzyme. Group: Enzymes. Synonyms: CLH; Chlase. Enzyme Commission Number: EC 3.1.1.14. CAS No. 9025-96-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3441; chlorophyllase; EC 3.1.1.14; 9025-96-1; CLH; Chlase. Cat No: EXWM-3441. | |
| Coenzyme Q10 | Coenzyme Q10 is an electron transport chain component of the mitochondria, which assists proton and electron transfer across the inner mitochondrial membrane. Studies indicate that Coenzyme Q10 can protect human endothelial cells from oxidative damage by modulating the nitric oxide pathway. In addition, Coenzyme Q10 inhibits LDL oxidation, a major process in the development of atherosclerosis. Coenzyme Q10 is known to suppress the down regulation of NOS3 (endothelial nitric oxide synthase, eNOS) and up-regulation of NOS2 (inducible nitric oxide synthase, iNOS). As a result of its ability to bind Ca2+, Coenzyme Q10 can transport this cation across artificial biomimetic membranes. Applications: A mitochondrial transporter chain component. Group: Coenzymes. Synonyms: CoQ10; Ubidecarenone; Ubiquinone-10; Q-10. CAS No. 303-98-0. Purity: ≥98%. Mole weight: 863.34. Appearance: Powder. Form: Solid. CoQ10; Ubidecarenone; Ubiquinone-10; Q-10; Coenzyme Q10; 303-98-0. Cat No: COEC-013. | |
| Cyclooxygenase 2 from Human, Recombinant | Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid to PGH2. Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 uM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme. Group: Enzymes. Synonyms: Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. COX-2. Mole weight: 70 kDa. Activity: >8,000 U/mg. Stability: > 6 months. Storage: -80°C (as supplied). Source: Sf21 cells. Species: Human. Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Cat No: NATE-1238. | |
| Cyclooxygenase 2 from Ovine, Recombinant | Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid to PGH2. Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 uM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme. Group: Enzymes. Synonyms: Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Purity: >80% estimated by SDS-PAGE. COX-2. Mole weight: ~70 kDa. Activity: >20,000 U/mg. Stability: > 6 months. Storage: -80°C (as supplied). Source: Sf21 cells. Species: Ovine. Cyclooxygenase 2; Inducible Cyclooxygenase Prostaglandin H Synthase 2; COX-2. Cat No: NATE-1239. | |
| Ethyl 3-Methyl-2-butenoate | Ethyl 3-Methyl-2-butenoate is used in the synthesis of Endothelin-A antagonist ABT-546 used in the preparation of antidepressant Rolipram. Also used in the synthesis of potent inhibitors of human inducible nitric oxide synthases, important enzymes in cellular signaling. Group: Biochemicals. Alternative Names: 3-Methyl-2-butenoic Acid Ethyl Ester; 3-Methyl-2-butenoic Acid Ethyl Ester; Ethyl 3,3-Dimethylacrylate; Ethyl 3-Methyl-2-butenoate; Ethyl 3-Methylcrotonate; Ethyl Dimethylacrylate; Ethyl Isobutenoate; Ethyl Isopropylideneacetate; Ethyl Senecioate; Ethyl β, β-Dimethylacrylate; Ethyl β-Methylcrotonate; NSC 61853; NSC 99208. Grades: Highly Purified. CAS No. 638-10-8. Pack Sizes: 10g. US Biological Life Sciences. |  Worldwide |
| formate dehydrogenase-N | The enzyme contains molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters and two heme b groups. Formate dehydrogenase-N oxidizes formate in the periplasm, transferring electrons via the menaquinone pool in the cytoplasmic membrane to a dissimilatory nitrate reductase (EC 1.7.5.1), which transfers electrons to nitrate in the cytoplasm. The system generates proton motive force under anaerobic conditions. Group: Enzymes. Synonyms: Fdh-N; FdnGHI; nitrate-inducible formate dehydrogenase; formate dehydrogenase N; FDH-N; nitrate inducible Fdn; nitrate inducible formate dehydrogenase. Enzyme Commission Number: EC 1.1.5.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0434; formate dehydrogenase-N; EC 1.1.5.6; Fdh-N; FdnGHI; nitrate-inducible formate dehydrogenase; formate dehydrogenase N; FDH-N; nitrate inducible Fdn; nitrate inducible formate dehydrogenase. Cat No: EXWM-0434. | |
| hypoxia-inducible factor-asparagine dioxygenase | Contains iron, and requires ascorbate. Catalyses hydroxylation of an asparagine in the C-terminal transcriptional activation domain of HIF-α, the α subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which reduces its interaction with the transcriptional coactivator protein p300. The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia. Group: Enzymes. Synonyms: HIF hydroxylase. Enzyme Commission Number: EC 1.14.11.30. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0648; hypoxia-inducible factor-asparagine dioxygenase; EC 1.14.11.30; HIF hydroxylase. Cat No: EXWM-0648. | |
| hypoxia-inducible factor-proline dioxygenase | Contains iron, and requires ascorbate. Specifically hydroxylates a proline residue in HIF-α, the α subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction.The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia. Group: Enzymes. Synonyms: HIF hydroxylase. Enzyme Commission Number: EC 1.14.11.29. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0646; hypoxia-inducible factor-proline dioxygenase; EC 1.14.11.29; HIF hydroxylase. Cat No: EXWM-0646. | |
| Keratinase, Recombinant | Keratinase is a particular class of extracellular proteolytic inducible enzyme with the capability of degrading insoluble keratin substrates. It is important for hydrolyzing hair, feather, and collagen in sewage system during waste water treatment. It is also useful in food industry, animal feed preparation etc. Insoluble feather keratin from poultry industry may be converted by enzymatic hydrolysis to glues, feedstuffs, fertilizers, films or used for the production of rare amino acids serine, cysteine and proline. Applications: Keratinase was used for enzymatic treatment of elementary body (eb), gag molecules, and cells in the study of the role glycosaminoglycans (gags) in the invasion of host cells by chlamydia pneumoniae strains. Group: Enzymes. Synonyms: Keratinase; KerA; Keratinase from Bacillus licheniformis; Keratinolytic protease; EC 3.4.21. Enzyme Commission Number: EC 3.4.21. Keratinase. Mole weight: ~39 kDa. Activity: 300 - 1000 units/mg. Storage: Store at -20°C. Form: Lyophilized powder. Source: E. coli BL21. Keratinase; KerA; Keratinase from Bacillus licheniformis; Keratinolytic protease; EC 3.4.21. Cat No: NATE-0853. | |
| L-Arabinose | L(+)-Arabinose is a pentose monosaccharide whose transcription is regulated by Ara-C proteins and is a substrate for L-arabinose dehydrogenase, galactose dehydrogenase. It is not fermented by yeast. Used as a one-way or reversible switch for protein expression. It is also used to make arabinosyl nucleosides. L-Arabinose is used as a substrate to identify, differentiate and characterize pentose sugar isomerase(s). L-Arabinose is used in the bioproduction of L-ribose. L-Arabinose is the naturally occurring isomer and is a constituent of plant polysaccharides. Most bacteria contain an inducible arabinose operon that codes for a series of enzymes and transporters that allows L-arabinose to be used as the sole carbon source in microbial culture. Group: Biochemicals. Alternative Names: Beta-L-Arabinopyranose; Beta-L-(+)-ARABINOSE; L-(+)-Arabinose; Pectinose; Arabitol, L-(-)-(RG); L-Arabinopyranose; (2R,3R,4S,5S)-oxane-2,3,4,5-tetrol. Grades: Reagent Grade. CAS No. 87-72-9. Pack Sizes: 100g, 500g, 1Kg, 2.5Kg. Molecular Formula:?C5H10O5 , Molecular Weight:?150.13. US Biological Life Sciences. | Worldwide |
| L-cysteate sulfo-lyase | A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing hydrogensulfite and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. D-Cysteine can also act as a substrate, but more slowly. It is converted into hydrogen sulfide, pyruvate, and ammonia. This inducible enzyme from the marine bacterium Silicibacter pomeroyi DSS-3 forms part of the cysteate-degradation pathway. Group: Enzymes. Synonyms: L-cysteate sulfo-lyase (deaminating); CuyA; L-cysteate bisulfite-lyase (deaminating; pyruvate-forming). Enzyme Commission Number: EC 4.4.1.25. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5327; L-cysteate sulfo-lyase; EC 4.4.1.25; L-cysteate sulfo-lyase (deaminating); CuyA; L-cysteate bisulfite-lyase (deaminating; pyruvate-forming). Cat No: EXWM-5327. | |
| N5-(1-Iminoethyl)-L-ornithine Dihydrochloride | N5-(1-Iminoethyl)-L-ornithine Dihydrochloride is an inhibitor of nitric oxide synthase (NOS), an enzyme that catalyzes the conversion of L-arginine to L-citrulline and nitric oxide. It also improves cardiac function and microcirculation. N5-(1-Iminoethyl)-L-ornithine Dihydrochloride inhibits inducible NOS (iNOS). These enzymes play critical roles in a wide array of physiological and pathophysiological conditions such as blood pressure regulation, inflammation, and infection. Group: Biochemicals. Grades: Highly Purified. CAS No. 159190-44-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C7H15N3O2 2HCl, Molecular Weight: 173.217291999999. US Biological Life Sciences. | Worldwide |
| naringenin 7-O-methyltransferase | The enzyme is involved in the biosynthesis of the sakuranetin, an inducible defense mechanism of the plant Oryza sativa (Asian rice) against pathogen attack. Group: Enzymes. Synonyms: NOMT. Enzyme Commission Number: EC 2.1.1.232. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1835; naringenin 7-O-methyltransferase; EC 2.1.1.232; NOMT. Cat No: EXWM-1835. | |
| Native Bacillus licheniformis Keratinase (feed grade) | Keratinase is a particular class of extracellular proteolytic inducible enzyme with the capability of degrading insoluble keratin substrates. It is important for hydrolyzing hair, feather, and collagen in sewage system during waste water treatment. It is also useful in food industry, animal feed preparation etc. Insoluble feather keratin from poultry industry may be converted by enzymatic hydrolysis to glues, feedstuffs, fertilizers, films or used for the production of rare amino acids serine, cysteine and proline. Group: Enzymes. Synonyms: KerA; Keratinolytic protease; EC 3.4.21. Enzyme Commission Number: EC 3.4.21. Keratinase. Form: Powder. Source: Bacillus licheniformis. Keratinase; KerA; Keratinase from Bacillus licheniformis; Keratinolytic protease; EC 3.4.21. Cat No: FEED-0001. | |
| Native Bacillus sp. Sarcosine Oxidase | Sarcosine oxidase is an enzyme (EC 1.5.3.1) that catalyzes the oxidative demethylation of sarcosine to yield glycine, H2O2, 5,10-CH2-tetrahydrofolate in a reaction requiring H4-tetrahydrofolate and oxygen. Corynebacterial sarcosine oxidase is a heterotetramer and is produced as an inducible enzyme when Corynebacterium sp.is grown with sarcosine as source of carbon and energy. Monomeric sarcosine oxidase (msox) is a flavoenzyme that catalyzes the oxidative demethylation of sarcosine (n-methylglycine) to yield glycine, formaldehyde, and hydrogen peroxide. monomeric sarcosine oxidase can oxidize other secondary amino acids such as n-methyl-l-alanine, n-ethylglycine, and l-proline. Applications: Sarcosine oxidase has been used in a study as part of a multienzyme cascade, that when immobilized constructed amperometric biosensors. sarcosine oxidase has also been used in a study to investigate oxidation of amines by flavoproteins. Group: Enzymes. Synonyms: Sarcosine oxidase; EC 1.5.3.1; 9029-22-5; sarcosine:oxygen oxidoreductase (demethylating). Enzyme Commission Number: EC 1.5.3.1. CAS No. 9029-22-5. SAO. Activity: 25-50 units/mg solid. Storage: -20°C. Form: lyophilized powder; No stabilizers added. Source: Bacillus sp. Sarcosine oxidase; EC 1.5.3.1; 9029-22-5; sarcosine:oxygen oxidoreductase (demethylating). Cat No: NATE-0664. | |
| Native Escherichia coli Penicillin Amidase | The biosynthesis of Penicillin amidase in E. coli by hydrophobic protein chromatography is an inducible reaction which is regulated by metabolized carbon source (e.g. polyols, carboxylic acid etc.). It is also influenced by catabolite repression. It catalyzes the formation of amide bonds through an acyl-enzyme intermediate. Penicillin amidase is a periplasmic 80k heterodimer with a and b chains (209 and 566 amino acids, respectively). it is widely distributed among microorganisms, including bacteria, yeast and filamentous fungi. among all the sources, the enzyme produced by e. coli is most well-characterized and common for industrial application. Applications: Penicillin...; benzylpenicillin acylase; novozym 217; semacylase; α-acylamino-β-lactam acylhydrolase; ampicillin acylase; EC 3.5.1.11; 9014-06-6. Enzyme Commission Number: EC 3.5.1.11. CAS No. 9014-6-6. Penicillin Amidase. Mole weight: Mr ~70 kDa. Activity: Type I, 5-10 units/mg protein; Type II, > 10 units/mg protein (E1%/280). Storage: 2-8°C. Form: Type II, ammonium sulfate suspension, Suspension in 0.1 M phosphate, pH 7.5 and 3 M ammonium sulfate. Source: Escherichia coli. penicillin amidase; penicillin acylase; benzylpenicillin acylase; novozym 217; semacylase; α-acylamino-β-lactam acylhydrolase; ampicillin acylase; EC 3.5.1.11; 9014-06-6. Cat No: NATE-0541. | |
| Native Flavobacterium heparinum Heparinase I and III Blend | Heparin-degrading lyase that recognizes heparin sulfate proteoglycan as its primary substrate. Heparinase I and III plays vital role in various biological processes: modulate cell-growth factor interactions, cell-lipoprotein interactions, neovascularization. It cleaves highly sulphated polysaccharide chains in presence of 2-O-sulfated α-L-idopyranosyluronic acid and β-D-glucopyranosyluronic acid residues of polysaccharides. Heparinase is an inducible, non-extracellular heparin-degrading enzyme. three types of heparinises are produced by flavobacterium heparinum and contains specific sequences of heparin. Applications: Heparinase i and iii may be used for the study of heparin production during fermentation and specific activity of heparinise. Group: Enzymes. Synonyms: Heparinase; Heparin lyase; Heparin eliminase; Heparin-sulfate lyase; Heparin-sulfate eliminase; Heparitin-sulfate lyase; Heparinase I; Heparinase III. Heparinase. Storage: -20°C. Source: Flavobacterium heparinum. Heparinase; Heparin lyase; Heparin eliminase; Heparin-sulfate lyase; Heparin-sulfate eliminase; Heparitin-sulfate lyase; Heparinase I; Heparinase III. Cat No: NATE-0337. | |
| Nitric Oxide Synthase, Inducible from mouse, Recombinant | Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, is involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free ...DPH); Inducible Nitric Oxide Synthase; NOS II; iNOS; macNOS; EC 1.14.13.39; NOSs. Enzyme Commission Number: EC 1.14.13.39. CAS No. 125978-95-2. NOSs. Mole weight: mol wt 130 kDa (homodimer); mol wt 130 kDa (subunit, homodimer). Storage: -70°C. Form: buffered aqueous solution; Solution in 50 mM HEPES, pH 7.4, with 10% glycerol, 8 μM tetrahydrobiopterin. Source: E. coli. Species: Mouse. nitric oxide synthetase; endothelium-derived relaxation factor-forming enzyme; endothelium-derived relaxing factor synthase; NO synthase; NADPH-diaphorase; nitric-oxide synthase (NADPH); Inducible Nitric Oxide Synthase; NOS II; iNOS; macNOS; EC 1.14.13.39; NOSs. Cat No: NATE-0489. | |
| Panobinostat | Panobinostat is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins. Uses: Antineoplastic agents. Synonyms: LBH589; LBH 589; LBH-589; NVP-LBH589; NVP-LBH 589; Panobinostat; trade name Farydak. Grades: >98%. CAS No. 404950-80-7. Molecular formula: C21H23N3O2. Mole weight: 349.434. |  |
| protein O-GlcNAcase | Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. EC 2.4.1.255 (protein O-GlcNAc transferase) transfers GlcNAc onto substrate proteins and EC 3.2.1.169 (protein O-GlcNAcase) cleaves GlcNAc from the modified proteins. Group: Enzymes. Synonyms: OGA; glycoside hydrolase O-GlcNAcase; O-GlcNAcase; BtGH84; O-GlcNAc hydrolase. Enzyme Commission Number: EC 3.2.1.169. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3851; protein O-GlcNAcase; EC 3.2.1.169; OGA; glycoside hydrolase O-GlcNAcase; O-GlcNAcase; BtGH84; O-GlcNAc hydrolase. Cat No: EXWM-3851. | |
| protein O-GlcNAc transferase | Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. EC 2.4.1.255 (protein O-GlcNAc transferase) transfers GlcNAc onto substrate proteins and EC 3.2.1.169 (protein O-GlcNAcase) cleaves GlcNAc from the modified proteins. Group: Enzymes. Synonyms: O-GlcNAc transferase; OGTase; O-linked N-acetylglucosaminyltransferase; uridine diphospho-N-acetylglucosamine:polypeptide β-N-acetylglucosaminyltransferase; protein O-linked β-N-acetylglucosamine transferase. Enzyme Commission Number: EC 2.4.1.255. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2485; protein O-GlcNAc transferase; EC 2.4.1.255; O-GlcNAc transferase; OGTase; O-linked N-acetylglucosaminyltransferase; uridine diphospho-N-acetylglucosamine:polypeptide β-N-acetylglucosaminyltransferase; protein O-linked β-N-acetylglucosamine transferase. Cat No: EXWM-2485. | |
| succinylornithine transaminase | A pyridoxal-phosphate protein. Also acts on N2-acetyl-L-ornithine and L-ornithine, but more slowly. In Pseudomonas aeruginosa, the arginine-inducible succinylornithine transaminase, acetylornithine transaminase (EC 2.6.1.11) and ornithine aminotransferase (EC 2.6.1.13) activities are catalysed by the same enzyme, but this is not the case in all species. This is the third enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase). Group: Enzymes. Synonyms: succinylornithine aminotr. Enzyme Commission Number: EC 2.6.1.81. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2922; succinylornithine transaminase; EC 2.6.1.81; succinylornithine aminotransferase; N2-succinylornithine 5-aminotransferase; AstC; SOAT; 2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase. Cat No: EXWM-2922. | |
| sulfoacetaldehyde reductase | Catalyses the reaction only in the opposite direction. Involved in taurine degradation. The bacterium Chromohalobacter salexigens strain DSM 3043 possesses two enzymes that catalyse this reaction, a constitutive enzyme (encoded by isfD2) and an inducible enzyme (encoded by isfD). The latter is induced by taurine, and is responsible for most of the activity observed in taurine-grown cells. Group: Enzymes. Synonyms: isfD (gene name). Enzyme Commission Number: EC 1.1.1.313. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0225; sulfoacetaldehyde reductase; EC 1.1.1.313; isfD (gene name). Cat No: EXWM-0225. | |
| Transmembrane glycoprotein NMB (179-188) | Transmembrane glycoprotein NMB (179-188) is a bioactive peptide of Transmembrane glycoprotein NMB which may be a melanogenic enzyme. Synonyms: Hematopoietic growth factor inducible neurokinin-1 type (179-188). | |
| Tricirbine | Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3. It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 μM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day. Synonyms: VQD-002; VQD 002; VQD002; NSC-154020; NSC 154020; NSC154020; Triciribine; TCN-P; triciribine; Tricyclic nucleoside; Pentaazacentopthylene; API-2; Akt Inhibitor V. Grades: 99.81%. CAS No. 35943-35-2. Molecular formula: C13H16N6O4. Mole weight: 320.309. | |
| 1,4:6,3-Glucarodilactone | 1,4:6,3-Glucarodilactone is a compound of significant value in the realms of biomedicine, finding wide application in the formulation of therapeutic drugs. By virtue of its ability to impede enzymatic activity, this compound effectively induces cellular apoptosis while concurrently curbing tumor cells proliferation. Synonyms: D-Glucaric acid 1,4:6,3-dilactone. CAS No. 826-91-5. Molecular formula: C6H6O6. Mole weight: 174.11. | |
| 16-Hydroxycleroda-3,13-dien-15,16-olide | 16-Hydroxycleroda-3,13-dien-15,16-olide is extracted from the unripe fruits of Polyalthia longifolia var. pendula. It is used as a candidate for autophagy inducers which can cause cell death in an alternative or supplement medicine for cancer therapy. It displays promising NO inhibitory activity at 10 ug/mL and shows anti-inflammatory activity. It induces apoptosis in CML K562 cells and regulates the expression of histone-modifying enzymes PRC2 complex. Synonyms: 5-Hydroxy-4-[2-[[(1S)-1,2,3,4,4a,7,8,8abeta-octahydro-1alpha,2alpha,4aalpha,5-tetramethylnaphthalen]-1-yl]ethyl]furan-2(5H)-one. Grades: 98.0%. CAS No. 141979-19-3. Molecular formula: C20H30O3. Mole weight: 318.45. | |
| 1-Methylpyrene | 1-Methylpyrene is a ubiquitous environmental pollutant and rodent carcinogen. Its mutagenic activity depends on sequential activation by various CYP and sulfotransferase (SULT) enzymes. 1-Methylpyrene induces chromosome loss and mitotic disturbance, proba. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2381-21-7. Pack Sizes: 10 mg. Product ID: HY-W271064. | |
| 2,3,4,6-Tetra-O-acetyl-a-D-galactopyranosyl fluoride | 2,3,4,6-Tetra-O-acetyl-a-D-galactopyranosyl fluoride, a highly versatile compound, finds extensive usage in synthesizing glycosylated natural and unnatural products, apart from serving as a glycosyl donor in enzymatic synthesis of carbohydrates, which has vastly diversified areas of applications. With its potential relevance in developing therapeutic molecules for treating complex pathologies like HIV and cancer, this product induces a great deal of scientific curiosity, owing to its intricate molecular architecture and intriguing mode of action. Synonyms: Acetofluoro-a-D-galactose; (2R,3S,4S,5R,6R)-2-(Acetoxymethyl)-6-fluorotetrahydro-2H-pyran-3,4,5-triyl triacetate; 1-Fluoro-1-deoxy-alpha-D-galactopyranose 2,3,4,6-tetraacetate; α-D-Galactopyranosyl fluoride, 2,3,4,6-tetraacetate. Grades: ≥98%. CAS No. 4163-44-4. Molecular formula: C14H19O9F. Mole weight: 350.29. | |
| 2,3,4,6-Tetra-O-acetyl-N-(β-D-galactopyranosyl)-N'-[(2-methanethiosulfonyl)ethyl]urea | 2,3,4,6-Tetra-O-acetyl-N-(β-D-galactopyranosyl)-N'-[(2-methanethiosulfonyl)ethyl]urea, a compelling biomedicine for cancer treatment, showcases its academic and scientific prowess. As a potent selective inhibitor, it deftly targets crucial enzymes implicated in tumor growth. Through its distinctive chemical composition, it proficiently impedes the proliferation of cancer cells, inducing apoptosis effectively. Synonyms: Acetyl-MTS-5-Galactose. Grades: 98%. Molecular formula: C18H28N2O12S2. Mole weight: 528.55. | |
| 2',3'-cUMP | 2',3'-cUMP, a nucleotide analog employed in biomedical research, exhibits promise in the treatment of diverse ailments such as cancer and viral infections. By serving as either a substrate or an inhibitor of specific enzymes implicated in DNA replication and RNA synthesis, it induces modifications within cellular mechanisms. Synonyms: Uridine- 2', 3'- cyclic monophosphate, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 15718-50-0. Molecular formula: C9H10N2O8P · Na. Mole weight: 328.2. | |
| 2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid | 2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid, a promising antifungal agent, possesses potent activity against Candidiasis and Aspergillosis. The compound targets 3-ketoacyl-ACP synthase III (FabH), a key enzyme in the biosynthesis of fungal fatty acids, and reduces fungal growth by inducing cellular membrane disruption through inhibition of FabH activity. With its unique mode of action, 2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid stands as a notably effective potential antifungal therapeutic candidate. Synonyms: 2H,3H-Thieno[3,4-B][1,4]dioxine-2-carboxylic acid; EDOT carboxylic acid; Carboxyedot. CAS No. 955373-67-8. Molecular formula: C7H6O4S. Mole weight: 186.181. | |
| 2'-Deoxy-5-hydroxymethylcytidine 5'-monophosphate sodium salt | 2'-Deoxy-5-hydroxymethylcytidine 5'-monophosphate sodium salt, a remarkable biomedicine, manifests immense potential in combating select viral infections. Mechanistically, it thwarts viral replication and diminishes viral load, largely attributed to its profound antiviral properties. Furthermore, owing to its unique pharmacological attributes, this compound aptly targets specific viral enzymes, thereby promulgating its efficacy against afflictions induced by such insidious viral strains. Molecular formula: C10H14N3Na2O8P. Mole weight: 381.19. | |
| 2'-Deoxy-5'-O-DMT-N2-(4-isopropylphenoxyacetyl)guanosine | 2'-Deoxy-5'-O-DMT-N2-(4-isopropylphenoxyacetyl)guanosine is a modified nucleotide analog, showcasing the ability to inhibit viral replication. Its exceptional chemical configuration allows for site-specific inhibition of viral enzymes, inducing a substantial decline in viral replication dynamics. Synonyms: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-[2-[4-(1-methylethyl)phenoxy]acetyl]guanosine. CAS No. 909415-65-2. Molecular formula: C42H43N5O8. Mole weight: 745.82. | |
| 2-Methoxy-9-(β-D-ribofuranosyl)purine | 2-Methoxy-9-(β-D-ribofuranosyl)purine, commonly known as a nucleoside analog, serves as a potent biomedicine primarily prescribed for combatting various cancerous conditions like leukemia and lymphoma. By intricately impeding DNA synthesis, this compound elegantly orchestrates the induction of apoptosis within malignant cells. The staggering potency of this therapeutic agent emanates from its remarkable capability to selectively target and disrupt enzymes and pathways involved in the aberrant proliferation of cancerous cells. Synonyms: 2-methoxy-9-beta-d-ribofuranosylpurine; (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(2-methoxy-9H-purin-9-yl)tetrahydrofuran-3,4-diol; 2-Methoxy-9-(β-D-ribofuranosyl)-9H-purine. Grades: ≥95%. CAS No. 39638-84-1. Molecular formula: C11H14N4O5. Mole weight: 282.25. | |
| 2-?Propyl-1,?3-?Dioxolane-?2-?acetic Acid | 2-?Propyl-1,?3-?Dioxolane-?2-?acetic Acid is an intermediate in synthesizing N-(Ketocaproyl)-L-homoserine Lactone (K180750), an autoinducer of P. fischeri luciferase. A specific genetic regulator that is unrelated to at least one of the enzyme systems that it induces, and it acts after excretion and accumulation in the extracellular medium. Group: Biochemicals. Grades: Highly Purified. CAS No. 5735-99-9. Pack Sizes: 500mg, 1g. Molecular Formula: C8H14O4. US Biological Life Sciences. | Worldwide |
| 2-Propyl-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-1,3-dioxolane-2-acetamide | 2-Propyl-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-1,3-dioxolane-2-acetamide is an intermediate in synthesizing N-(Ketocaproyl)-L-homoserine Lactone (K180750), an autoinducer of P. fischeri luciferase. A specific genetic regulator that is unrelated to at least one of the enzyme systems that it induces, and it acts after excretion and accumulation in the extracellular medium. Group: Biochemicals. Grades: Highly Purified. CAS No. 1083287-09-5. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H19NO5. US Biological Life Sciences. | Worldwide |
| (2S, ?3S, ?4R) ?-3-?[[[ (2S, ?3S, ?4R) ?-?3-?[[[ (2S, ?3S, ?4R) ?-?3-?Azido-?4-?[[[ (1, ?1-?dimethylethyl) ?dimethylsilyl]?oxy]?methyl]?-?1-? (phenylmethyl) ?-?2-?azetidinyl]?carbonyl]?amino]?-?4-?[[[ (1, ?1-?dimethylethyl) ?dimethylsilyl]?oxy]?methyl]?-?1-? (phenylmethyl) ?-?2-?azetidinyl]?carbonyl]?amino]?-?4-?[[[ (1, ?1-?dimethylethyl) ?dimethylsilyl]?oxy]?methyl]?-?1-? (phenylmethyl) ?-2-?azetidinecarboxylic acid methyl ester | (2S, 3S, 4R) -3-[[[ (2S, 3S, 4R) -3-Azido-4-[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]methyl]-1- (phenylmethyl) -2-azetidinyl]carbonyl]-4-[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]methyl]-1- (phenylmethyl) -2-azetidinyl]carbonyl]-4-[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]methyl-1- (phenylmethyl) -2-azetidinecarboxylic acid methyl ester, a novel and highly potent inhibitor, exhibits remarkable selectivity for cancer treatment research. By specifically targeting crucial enzymes implicated in tumor growth and proliferation, this compound induces apoptotic cell death while suppressing angiogenesis. CAS No. 1992035-05-8. Molecular formula: C55H86N8O7Si3. Mole weight: 1055.58. | |
| 3,4-Dichloroisocoumarin | 3,4-Dichloroisocoumarin is a potent serine-protease and SrLip inhibitor (K i for SrLip: 26.6 μM). 3,4-Dichloroisocoumarin is opened by serine proteases and then undergoes acylation with the enzyme, thereby inhibiting protease activity. 3,4-Dichloroisocoumarin can induce DNA fragmentation and Apoptosis. 3,4-Dichloroisocoumarin can be used in the research of multiple fields such as tumors, cardiovascular disease and enzyme catalytic mechanisms [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 51050-59-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-126034. | |
| 3,5-Di-O-benzyl-2-deoxy-2-fluoro-D-ribono-1,4-lactone | 3,5-Di-O-benzyl-2-deoxy-2-fluoro-D-ribono-1,4-lactone is an incredibly potent compound extensively utilized in the research of a myriad of ailments, such as neoplastic disorders and viral afflictions. This remarkable compound effectively targets distinct intracellular pathways while obstructing pivotal disease-inducing enzymes. Synonyms: 2-Deoxy-2-fluoro-3,5-bis-O-(phenylmethyl) ribonic acid gamma-lactone. CAS No. 1355049-97-6. Molecular formula: C19H19FO4. Mole weight: 330.35. | |
| 3-Chloro-L-tyrosine | 3-Chloro-L-tyrosine was used in the enzymatic synthesis of halogen derivatives of aromatic amino acids labeled with hydrogen isotope. 3-Chloro-L-tyrosine exhibited stronger antioxidant properties in Hb-induced oxidative stress as was evident by higher efficiency of reduction of ferryl species. Synonyms: 3-Chloro-L-Tyr-OH; 3-Chloro-4-hydroxy-L-phenylalanine; 3-Chlorotyrosine; 3-Cl-Tyr-OH; (S)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid; (2S)-2-amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid; CLY; H-Tyr(3-Cl)-OH. Grades: ≥ 99% (HPLC). CAS No. 7423-93-0. Molecular formula: C9H10NO3Cl. Mole weight: 215.63. | |
| 3-Deaza-3-methyl-2'-deoxyadenosine | 3-Deaza-3-methyl-2'-deoxyadenosine is an exceptionally potent antiviral compound harnessed in the sphere of biomedical sciences. Discerningly exerting its inhibitory prowess upon the viral RNA polymerase enzyme, this compound manifests a compelling prospect for the research of the afflictions induced by these formidable viral invasions. Grades: ≥ 97%. CAS No. 515815-12-0. Molecular formula: C12H16N4O3. Mole weight: 264.28. | |
| 3H-1,2-Dithiole-3-thione (D3T) | A chemoprotective chemical. It is known to induce detoxication enzymes and inhibit chemica-induced tumors in multiple tissues. Group: Biochemicals. Alternative Names: D3T. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 3-Methylglutaconic acid | 3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: β-Methylglutaconic acid. CAS No. 5746-90-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-139427. | |
| (3R,6E)-nerolidol synthase | The enzyme catalyses a step in the formation of (3E)-4,8-dimethylnona-1,3,7-triene, a key signal molecule in induced plant defense mediated by the attraction of enemies of herbivores. Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants. Group: Enzymes. Synonyms: terpene synthase 1. Enzyme Commission Number: EC 4.2.3.49. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5208; (3R,6E)-nerolidol synthase; EC 4.2.3.49; terpene synthase 1. Cat No: EXWM-5208. | |
| (3S,6E)-nerolidol synthase | The enzyme catalyses a step in the formation of (3E)-4,8-dimethylnona-1,3,7-triene, a key signal molecule in induced plant defense mediated by the attraction of enemies of herbivores. Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants. Group: Enzymes. Synonyms: (E)-nerolidol synthase; nerolidol synthase; (3S)-(E)-nerolidol synthase; FaNES1. Enzyme Commission Number: EC 4.2.3.48. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5207; (3S,6E)-nerolidol synthase; EC 4.2.3.48; (E)-nerolidol synthase; nerolidol synthase; (3S)-(E)-nerolidol synthase; FaNES1. Cat No: EXWM-5207. | |
| 4-Bromoflavone | An aryl hydrocarbon hydroxylase inducer. Used as a phase II detoxifying enzymes, quninone reductase and glutathione S-transferase in cell culture and in different tissues of rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 4-Hydroxyisophthalic acid | 4-Hydroxyisophthalic acid activates antioxidant enzymes (such as catalase CAT and superoxide dismutase SOD ), scavenges free radicals, and exhibits antioxidant property. 4-Hydroxyisophthalic acid activates AChE and BChE , enhances neuronal function and improves Tau-induced neurobehavioral defects. 4-Hydroxyisophthalic acid improves the cognitive defects, and ameliorates circadian rhythm disorders of fruit flies [1]. Uses: Scientific research. Group: Natural products. CAS No. 636-46-4. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-76632. | |
| 4-Methylphenyl b-D-thiogalactopyranoside | 4-Methylphenyl β-D-thiogalactopyranoside is a synthetic compound acting as a substrate for the enzyme β-D-galactosidase and can be used to induce gene expression in studies related to the lac operon. This compound is particularly useful in molecular biology research for investigating the regulation of gene expression and analyzing protein interactions. Synonyms: 4-METHYLPHENYLTHIO-BETA-D-GALACTOPYRANOSIDE; CHEMBL4064722; (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(p-tolylthio)tetrahydro-2H-pyran-3,4,5-triol; (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-(4-methylphenyl)sulfanyloxane-3,4,5-triol; 4-Methylphenyl 1-thio-b-D-galactopyranoside; SCHEMBL3824089; IQCLIQLFPVKINX-SJHCENCUSA-N; BDBM50247500; 4-Methylphenylthio-?-D-galactopyranoside; 4-Methylphenylthio-b-D-galactopyranoside; WS-02057; CS-0113028; 4-Methylphenylthio- beta -D-galactopyranoside; D77177; p-Methylphenyl 1-thio-beta-D-galactopyranoside; p-Methylphenyl 1 -thio-beta-D-galactopyranoside; W-202184. CAS No. 28244-98-6. Molecular formula: C13H18O5S. Mole weight: 286.35. | |
| 4-Nitrophenyl laurate | 4-Nitrophenyl laurate, a remarkable biomedicine with a captivating name, astounds the scientific realm by its stupendous potential in addressing cardiovascular afflictions, foremost among them being hypertension. Serving as an exceptionally vigorous inhibitor, this marvel counters the nefarious actions of angiotensin converting enzyme (ACE), an enzyme pivotal in the intricate orchestration of blood pressure control. Alas, its grandeur does not cease there! This exceptional compound, through its ACE inhibition, showcases the power to induce vasodilation and alleviate blood pressure concerns, a beacon of hope for individuals burdened by cardiovascular malaise. Synonyms: 4-Nitrophenyl dodecanoate. CAS No. 1956-11-2. Molecular formula: C18H27NO4. Mole weight: 321.41. | |
| 4-Octyl itaconate | 4-Octyl itaconate is a prodrug form of itaconate, an endogenous cellular metabolite produced via decarboxylation of cis-aconitate by the enzyme encoded by IRG1. It activates Nrf2. It inhibits LPS-induced increases in IL-1β mRNA, HIF-1α and IL-10 in macrophages. It decreases cytokine production in response to LPS in mice and prolongs survival. Synonyms: Itaconic acid 4-octyl ester; 2-Methylidene-4-octoxy-4-oxobutanoic acid. Grades: ≥98%. CAS No. 3133-16-2. Molecular formula: C13H22O4. Mole weight: 242.3. | |
| 5,6-Benzoflavone | 5,6-Benzoflavone is a polyaromatic hydrocarbon receptor agonist that induces detoxification enzymes such as P450. Synonyms: Beta-naphthoflavone; Beta-NF; 3-Phenyl-1H-benzo[f]chromen-1-one; 3-Phenyl-1H-naphtho(2,1-b)pyran-1-one. CAS No. 6051-87-2. Molecular formula: C19H12O2. Mole weight: 272.303. | |
| 5,6-Epoxyeicosatrienoic acid | 5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 ( IC 50 =0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5,6-EET; (±)5,6-EpETrE. CAS No. 87173-80-6. Pack Sizes: 25 μg (312.04 μM * 250 μL in Ethanol); 50 μg (312.04 μM * 500 μL in Ethanol); 100 μg (312.04 μM * 1 mL in Ethanol). Product ID: HY-132184. | |
| 5-Bromo-4-chloro-3-indolyl b-D-fucopyranoside | 5-Bromo-4-chloro-3-indolyl b-D-fucopyranoside, a ubiquitous substrate in molecular and cell biology, is utilized as a tool to indicate the presence of beta-galactosidase in the targeted cells. Upon cleavage by the enzyme, the formerly dormant substrate induces a conspicuously blue hue that unmistakably confirms gene expression and sheds light on cellular localization. Synonyms: X-b-D-Fucoside. CAS No. 17016-46-5. Molecular formula: C14H15BrClNO5. Mole weight: 392.63. | |
| 5-Hydroxymethyl-2',3'-di-O-isopropylidene-2-thiouridine | 5-Hydroxymethyl-2',3'-di-O-isopropylidene-2-thiouridine is a profoundly effective compound, meticulously utilized for research of pernicious viral infections triggered by RNA viruses. Its exceptional antiviral characteristics stem from its remarkable affinity towards targeting specific viral enzymes, unfolding a paradigm shift towards obstructing viral replication and mitigating virus-induced pathogenesis. Synonyms: 5-(hydroxymethyl)-1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; 2'-O,3'-O-Isopropylidene-5-(hydroxymethyl)-2-thiouridine; 5-(hydroxymethyl)-2',3'-O-(1-methylethylidene)-2-thio-uridine; 5-(Hydroxymethyl)-1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone. Grades: ≥95%. CAS No. 58479-71-3. Molecular formula: C13H18N2O6S. Mole weight: 330.36. | |
| 5'-O-Acetyl-2',3'-dideoxyinosine | 5'-O-Acetyl-2',3'-dideoxyinosine is an extensively utilized potent antiviral compound within the biomedical field, exhibiting impressive efficacy in research of viral infections induced by the human immunodeficiency virus (HIV). By impeding the reverse transcriptase enzyme, a pivotal factor for viral replication, this compound effectively impedes viral multiplication. Synonyms: 5'-O-Acetyldidanosine; 5'-O-Acetyl-2',3'-dideoxy-D-inosine. CAS No. 130676-58-3. Molecular formula: C12H14N4O4. Mole weight: 278.26. | |
| 5'-O-Acetyllamivudine | 5'-O-Acetyllamivudine, an exceedingly potent antiviral medication, serves as a remarkable treatment option for individuals grappling with the burdensome hepatitis B virus (HBV) infection. By skillfully obstructing the activity of the reverse transcriptase enzyme, it diligently thwarts the replication of viral DNA, thereby engendering an impediment to the proliferation of the virus. The unique structural configuration and intricate biochemical attributes of this remarkable compound provide a glimmer of hope in the realm of crafting efficacious therapies targeting HBV-induced maladies. CAS No. 151767-03-2. Molecular formula: C10H13N3O4S. Mole weight: 271.29. | |
| 5'-O-tert-Butyldimethylsilyl-2',3'-dideoxy-3'-fluorouridine | 5'-O-tert-Butyldimethylsilyl-2',3'-dideoxy-3'-fluorouridine, an indispensable compound in the biomedical field, holds immense significance. Widely employed for tackling viral infections induced by specific retroviruses, such as Human Immunodeficiency Virus (HIV), it showcases remarkable antiviral attributes through the inhibition of reverse transcriptase, a pivotal viral replication enzyme. Synonyms: 5'-O-tert-Butyldimethylsilyl-2',3'-dideoxy-3'-fluoro-D-uridine. Molecular formula: C15H25FN2O4Si. Mole weight: 344.45. | |
| 5'-O-Tritylinosine | KIN59 is a purine riboside derivative that suppresses thymidine phosphorylase (TPase). TPase is an enzyme catalyzing the reversible phosphorolysis of pyrimidine deoxynucleosides to 2-deoxy-d-ribose-1-phosphate and their respective pyrimidine bases. KIN59 noncompetitively inhibits TPase-induced angiogenesis in the chorioallantoic membrane assay. Synonyms: 5'-Trt-rI; (2R,3R,4S,5R)-9-(3,4-Dihydroxy-5-trityloxymethyl-tetrahydrofuran-2-yl)-1,9-dihydropurin-6-one; KIN-59; Inosine, 5'-O-(triphenylmethyl)-; 5'-O-(triphenylmethyl)-inosine. Grades: ≥98% by HPLC. CAS No. 4152-77-6. Molecular formula: C29H26N4O5. Mole weight: 510.55. | |
| 6-(2H4-Furfurylamino)purine riboside | 6-(2H4-Furfurylamino)purine riboside is an outstanding and discriminating antagonist, finding extensive application in the research of diverse ailments encompassing malignancy and viral infestations. It exerts its effect by precisely aiming at particular enzymatic entities, thereby inducing obstruction of anomalous cellular proliferation and impeding viral particle duplication. Synonyms: Kinetin-d4 riboside. | |
| (6-4)DNA photolyase | A flavoprotein (FAD). The overall repair reaction consists of two distinct steps, one of which is light-independent and the other one light-dependent. In the initial light-independent step, a 6-iminium ion is thought to be generated via proton transfer induced by two histidines highly conserved among the (6-4) photolyases. This intermediate spontaneously rearranges to form an oxetane intermediate by intramolecular nucleophilic attack. In the subsequent light-driven reaction, one electron is believed to be transferred from the fully reduced FAD cofactor (FADH-) to the oxetane intermediate thus forming a neutral FADH radical and an anionic oxetane radical, which spontaneously fractures. The excess electron is then back-transferred to the flavin radical restoring the fully reduced flavin cofactor and a pair of pyrimidine bases. Group: Enzymes. Synonyms: DNA photolyase; H64PRH; NF-10; phr (6-4); PL-(6-4); OtCPF1; (6-4) PHR; At64PHR. Enzyme Commission Number: EC 4.1.99.13. CAS No. 37290-70-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4928; (6-4)DNA photolyase; EC 4.1.99.13; 37290-70-3; DNA photolyase; H64PRH; NF-10; phr (6-4); PL-(6-4); OtCPF1; (6-4) PHR; At64PHR. Cat No: EXWM-4928. | |
| 6-Amino-4-methoxy-1-(2-deoxy-a-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine | 6-Amino-4-methoxy-1-(2-deoxy-a-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, an efficacious antiviral agent extensively employed in biomedicine, exhibits significant inhibitory effects on viral RNA replication via selective targeting of pivotal enzymes implicated in viral replication processes. Notably, this compound showcases promising outcomes in combatting RNA virus-induced infections. Synonyms: 6-Amino-4-methoxy-1-(2-deoxy-alpha-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine; (2R,3S,5S)-5-(6-amino-4-methoxypyrazolo[3,4-d]pyrimidin-1-yl)-2-(hydroxymethyl)oxolan-3-ol. Grades: ≥95%. Molecular formula: C11H15N5O4. Mole weight: 281.27. | |
| 6-Aminonicotinamide | 6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM). 6-Aminonicotinamide is a PGD inhibitor and apoptosis inducer. Uses: Teratogens. Synonyms: 6-aminopyridine-3-carboxamide. Grades: 95 %. CAS No. 329-89-5. Molecular formula: C6H7N3O. Mole weight: 137.14. | |
| 6-Chloro-3-indolyl b-D-cellobioside | 6-Chloro-3-indolyl β-D-cellobioside, a remarkable substrate extensively utilized in the field of biomedicine, serves as a potent tool for detecting and scrutinizing the activity of β-glucosidase enzymes. Manifesting as a chromogenic substrate of utmost significance, it has found widespread usage in the investigation of inhibitory and inductive effects on β-glucosidases within diverse maladies and pharmaceutical advancements. Synonyms: Salmon-cellobioside. CAS No. 425427-87-8. Molecular formula: C20H26ClNO11. Mole weight: 491.87. | |
| 6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole (Triclabendazole) | Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.1 In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinsons disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.2,3. Group: Biochemicals. Alternative Names: 5-Chloro-6- (2, 3-dichlorophenoxy) -2- methyl thiobenzimidazole; CGA-89317, egaten; Fasinex; Triclabendazole. Grades: Highly Purified. CAS No. 68786-66-3. Pack Sizes: 25g, 50g, 100g. Molecular Formula: C14H9Cl3N2OS, Molecular Weight: 359.66. US Biological Life Sciences. | Worldwide |
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