Inducible Enzyme Suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
Product | Description | |
---|---|---|
1,4:6,3-Glucarodilactone Quick inquiry Where to buy Suppliers range | 1,4:6,3-Glucarodilactone is a compound of significant value in the realms of biomedicine, finding wide application in the formulation of therapeutic drugs. By virtue of its ability to impede enzymatic activity, this compound effectively induces cellular apoptosis while concurrently curbing tumor cells proliferation. Synonyms: D-Glucaric acid 1,4:6,3-dilactone. CAS No. 826-91-5. Molecular formula: C6H6O6. Mole weight: 174.11. | |
16-Hydroxycleroda-3,13-dien-15,16-olide Quick inquiry Where to buy Suppliers range | 16-Hydroxycleroda-3,13-dien-15,16-olide is extracted from the unripe fruits of Polyalthia longifolia var. pendula. It is used as a candidate for autophagy inducers which can cause cell death in an alternative or supplement medicine for cancer therapy. It displays promising NO inhibitory activity at 10 ug/mL and shows anti-inflammatory activity. It induces apoptosis in CML K562 cells and regulates the expression of histone-modifying enzymes PRC2 complex. Synonyms: 5-Hydroxy-4-[2-[[(1S)-1,2,3,4,4a,7,8,8abeta-octahydro-1alpha,2alpha,4aalpha,5-tetramethylnaphthalen]-1-yl]ethyl]furan-2(5H)-one. Grades: 98.0%. CAS No. 141979-19-3. Molecular formula: C20H30O3. Mole weight: 318.45. | |
2,3,4,6-Tetra-O-acetyl-a-D-galactopyranosyl fluoride Quick inquiry Where to buy Suppliers range | 2,3,4,6-Tetra-O-acetyl-a-D-galactopyranosyl fluoride, a highly versatile compound, finds extensive usage in synthesizing glycosylated natural and unnatural products, apart from serving as a glycosyl donor in enzymatic synthesis of carbohydrates, which has vastly diversified areas of applications. With its potential relevance in developing therapeutic molecules for treating complex pathologies like HIV and cancer, this product induces a great deal of scientific curiosity, owing to its intricate molecular architecture and intriguing mode of action. Synonyms: Acetofluoro-a-D-galactose; (2R,3S,4S,5R,6R)-2-(Acetoxymethyl)-6-fluorotetrahydro-2H-pyran-3,4,5-triyl triacetate; 1-Fluoro-1-deoxy-alpha-D-galactopyranose 2,3,4,6-tetraacetate; α-D-Galactopyranosyl fluoride, 2,3,4,6-tetraacetate. Grades: ≥98%. CAS No. 4163-44-4. Molecular formula: C14H19O9F. Mole weight: 350.29. | |
2,3,4,6-Tetra-O-acetyl-N-(β-D-galactopyranosyl)-N'-[(2-methanethiosulfonyl)ethyl]urea Quick inquiry Where to buy Suppliers range | 2,3,4,6-Tetra-O-acetyl-N-(β-D-galactopyranosyl)-N'-[(2-methanethiosulfonyl)ethyl]urea, a compelling biomedicine for cancer treatment, showcases its academic and scientific prowess. As a potent selective inhibitor, it deftly targets crucial enzymes implicated in tumor growth. Through its distinctive chemical composition, it proficiently impedes the proliferation of cancer cells, inducing apoptosis effectively. Synonyms: Acetyl-MTS-5-Galactose. Grades: 98%. Molecular formula: C18H28N2O12S2. Mole weight: 528.55. | |
2',3'-cUMP Quick inquiry Where to buy Suppliers range | 2',3'-cUMP, a nucleotide analog employed in biomedical research, exhibits promise in the treatment of diverse ailments such as cancer and viral infections. By serving as either a substrate or an inhibitor of specific enzymes implicated in DNA replication and RNA synthesis, it induces modifications within cellular mechanisms. Synonyms: Uridine- 2', 3'- cyclic monophosphate, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 15718-50-0. Molecular formula: C9H10N2O8P · Na. Mole weight: 328.2. | |
2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid Quick inquiry Where to buy Suppliers range | 2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid, a promising antifungal agent, possesses potent activity against Candidiasis and Aspergillosis. The compound targets 3-ketoacyl-ACP synthase III (FabH), a key enzyme in the biosynthesis of fungal fatty acids, and reduces fungal growth by inducing cellular membrane disruption through inhibition of FabH activity. With its unique mode of action, 2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid stands as a notably effective potential antifungal therapeutic candidate. Synonyms: 2H,3H-Thieno[3,4-B][1,4]dioxine-2-carboxylic acid; EDOT carboxylic acid; Carboxyedot. CAS No. 955373-67-8. Molecular formula: C7H6O4S. Mole weight: 186.181. | |
2'-Deoxy-5-hydroxymethylcytidine 5'-monophosphate sodium salt Quick inquiry Where to buy Suppliers range | 2'-Deoxy-5-hydroxymethylcytidine 5'-monophosphate sodium salt, a remarkable biomedicine, manifests immense potential in combating select viral infections. Mechanistically, it thwarts viral replication and diminishes viral load, largely attributed to its profound antiviral properties. Furthermore, owing to its unique pharmacological attributes, this compound aptly targets specific viral enzymes, thereby promulgating its efficacy against afflictions induced by such insidious viral strains. Molecular formula: C10H14N3Na2O8P. Mole weight: 381.19. | |
2'-Deoxy-5'-O-DMT-N2-(4-isopropylphenoxyacetyl)guanosine Quick inquiry Where to buy Suppliers range | 2'-Deoxy-5'-O-DMT-N2-(4-isopropylphenoxyacetyl)guanosine is a modified nucleotide analog, showcasing the ability to inhibit viral replication. Its exceptional chemical configuration allows for site-specific inhibition of viral enzymes, inducing a substantial decline in viral replication dynamics. Synonyms: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-[2-[4-(1-methylethyl)phenoxy]acetyl]guanosine. CAS No. 909415-65-2. Molecular formula: C42H43N5O8. Mole weight: 745.82. | |
2-Methoxy-9-(β-D-ribofuranosyl)purine Quick inquiry Where to buy Suppliers range | 2-Methoxy-9-(β-D-ribofuranosyl)purine, commonly known as a nucleoside analog, serves as a potent biomedicine primarily prescribed for combatting various cancerous conditions like leukemia and lymphoma. By intricately impeding DNA synthesis, this compound elegantly orchestrates the induction of apoptosis within malignant cells. The staggering potency of this therapeutic agent emanates from its remarkable capability to selectively target and disrupt enzymes and pathways involved in the aberrant proliferation of cancerous cells. Synonyms: 2-methoxy-9-beta-d-ribofuranosylpurine; (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(2-methoxy-9H-purin-9-yl)tetrahydrofuran-3,4-diol; 2-Methoxy-9-(β-D-ribofuranosyl)-9H-purine. Grades: ≥95%. CAS No. 39638-84-1. Molecular formula: C11H14N4O5. Mole weight: 282.25. | |
2-?Propyl-1,?3-?Dioxolane-?2-?acetic Acid Quick inquiry Where to buy Suppliers range | 2-?Propyl-1,?3-?Dioxolane-?2-?acetic Acid is an intermediate in synthesizing N-(Ketocaproyl)-L-homoserine Lactone (K180750), an autoinducer of P. fischeri luciferase. A specific genetic regulator that is unrelated to at least one of the enzyme systems that it induces, and it acts after excretion and accumulation in the extracellular medium. Group: Biochemicals. Grades: Highly Purified. CAS No. 5735-99-9. Pack Sizes: 500mg, 1g. Molecular Formula: C8H14O4. US Biological Life Sciences. | Worldwide |
2-Propyl-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-1,3-dioxolane-2-acetamide Quick inquiry Where to buy Suppliers range | 2-Propyl-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-1,3-dioxolane-2-acetamide is an intermediate in synthesizing N-(Ketocaproyl)-L-homoserine Lactone (K180750), an autoinducer of P. fischeri luciferase. A specific genetic regulator that is unrelated to at least one of the enzyme systems that it induces, and it acts after excretion and accumulation in the extracellular medium. Group: Biochemicals. Grades: Highly Purified. CAS No. 1083287-09-5. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H19NO5. US Biological Life Sciences. | Worldwide |
(2S, ?3S, ?4R) ?-3-?[[[ (2S, ?3S, ?4R) ?-?3-?[[[ (2S, ?3S, ?4R) ?-?3-?Azido-?4-?[[[ (1, ?1-?dimethylethyl) ?dimethylsilyl]?oxy]?methyl]?-?1-? (phenylmethyl) ?-?2-?azetidinyl]?carbonyl]?amino]?-?4-?[[[ (1, ?1-?dimethylethyl) ?dimethylsilyl]?oxy]?methyl]?-?1-? (phenylmethyl) ?-?2-?azetidinyl]?carbonyl]?amino]?-?4-?[[[ (1, ?1-?dimethylethyl) ?dimethylsilyl]?oxy]?methyl]?-?1-? (phenylmethyl) ?-2-?azetidinecarboxylic acid methyl ester Quick inquiry Where to buy Suppliers range | (2S, 3S, 4R) -3-[[[ (2S, 3S, 4R) -3-Azido-4-[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]methyl]-1- (phenylmethyl) -2-azetidinyl]carbonyl]-4-[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]methyl]-1- (phenylmethyl) -2-azetidinyl]carbonyl]-4-[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]methyl-1- (phenylmethyl) -2-azetidinecarboxylic acid methyl ester, a novel and highly potent inhibitor, exhibits remarkable selectivity for cancer treatment research. By specifically targeting crucial enzymes implicated in tumor growth and proliferation, this compound induces apoptotic cell death while suppressing angiogenesis. CAS No. 1992035-05-8. Molecular formula: C55H86N8O7Si3. Mole weight: 1055.58. | |
3,5-Di-O-benzyl-2-deoxy-2-fluoro-D-ribono-1,4-lactone Quick inquiry Where to buy Suppliers range | 3,5-Di-O-benzyl-2-deoxy-2-fluoro-D-ribono-1,4-lactone is an incredibly potent compound extensively utilized in the research of a myriad of ailments, such as neoplastic disorders and viral afflictions. This remarkable compound effectively targets distinct intracellular pathways while obstructing pivotal disease-inducing enzymes. Synonyms: 2-Deoxy-2-fluoro-3,5-bis-O-(phenylmethyl) ribonic acid gamma-lactone. CAS No. 1355049-97-6. Molecular formula: C19H19FO4. Mole weight: 330.35. | |
3-Chloro-L-tyrosine Quick inquiry Where to buy Suppliers range | 3-Chloro-L-tyrosine was used in the enzymatic synthesis of halogen derivatives of aromatic amino acids labeled with hydrogen isotope. 3-Chloro-L-tyrosine exhibited stronger antioxidant properties in Hb-induced oxidative stress as was evident by higher efficiency of reduction of ferryl species. Synonyms: 3-Chloro-L-Tyr-OH; 3-Chloro-4-hydroxy-L-phenylalanine; 3-Chlorotyrosine; 3-Cl-Tyr-OH; (S)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid; (2S)-2-amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid; CLY; H-Tyr(3-Cl)-OH. Grades: ≥ 99% (HPLC). CAS No. 7423-93-0. Molecular formula: C9H10NO3Cl. Mole weight: 215.63. | |
3-Deaza-3-methyl-2'-deoxyadenosine Quick inquiry Where to buy Suppliers range | 3-Deaza-3-methyl-2'-deoxyadenosine is an exceptionally potent antiviral compound harnessed in the sphere of biomedical sciences. Discerningly exerting its inhibitory prowess upon the viral RNA polymerase enzyme, this compound manifests a compelling prospect for the research of the afflictions induced by these formidable viral invasions. Grades: ≥ 97%. CAS No. 515815-12-0. Molecular formula: C12H16N4O3. Mole weight: 264.28. | |
3H-1,2-Dithiole-3-thione (D3T) Quick inquiry Where to buy Suppliers range | A chemoprotective chemical. It is known to induce detoxication enzymes and inhibit chemica-induced tumors in multiple tissues. Group: Biochemicals. Alternative Names: D3T. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
4-Bromoflavone Quick inquiry Where to buy Suppliers range | An aryl hydrocarbon hydroxylase inducer. Used as a phase II detoxifying enzymes, quninone reductase and glutathione S-transferase in cell culture and in different tissues of rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
4-Methylphenyl b-D-thiogalactopyranoside Quick inquiry Where to buy Suppliers range | 4-Methylphenyl β-D-thiogalactopyranoside is a synthetic compound acting as a substrate for the enzyme β-D-galactosidase and can be used to induce gene expression in studies related to the lac operon. This compound is particularly useful in molecular biology research for investigating the regulation of gene expression and analyzing protein interactions. Synonyms: 4-METHYLPHENYLTHIO-BETA-D-GALACTOPYRANOSIDE; CHEMBL4064722; (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(p-tolylthio)tetrahydro-2H-pyran-3,4,5-triol; (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-(4-methylphenyl)sulfanyloxane-3,4,5-triol; 4-Methylphenyl 1-thio-b-D-galactopyranoside; SCHEMBL3824089; IQCLIQLFPVKINX-SJHCENCUSA-N; BDBM50247500; 4-Methylphenylthio-?-D-galactopyranoside; 4-Methylphenylthio-b-D-galactopyranoside; WS-02057; CS-0113028; 4-Methylphenylthio- beta -D-galactopyranoside; D77177; p-Methylphenyl 1-thio-beta-D-galactopyranoside; p-Methylphenyl 1 -thio-beta-D-galactopyranoside; W-202184. CAS No. 28244-98-6. Molecular formula: C13H18O5S. Mole weight: 286.35. | |
4-Nitrophenyl laurate Quick inquiry Where to buy Suppliers range | 4-Nitrophenyl laurate, a remarkable biomedicine with a captivating name, astounds the scientific realm by its stupendous potential in addressing cardiovascular afflictions, foremost among them being hypertension. Serving as an exceptionally vigorous inhibitor, this marvel counters the nefarious actions of angiotensin converting enzyme (ACE), an enzyme pivotal in the intricate orchestration of blood pressure control. Alas, its grandeur does not cease there! This exceptional compound, through its ACE inhibition, showcases the power to induce vasodilation and alleviate blood pressure concerns, a beacon of hope for individuals burdened by cardiovascular malaise. Synonyms: 4-Nitrophenyl dodecanoate. CAS No. 1956-11-2. Molecular formula: C18H27NO4. Mole weight: 321.41. | |
4-Octyl itaconate Quick inquiry Where to buy Suppliers range | 4-Octyl itaconate is a prodrug form of itaconate, an endogenous cellular metabolite produced via decarboxylation of cis-aconitate by the enzyme encoded by IRG1. It activates Nrf2. It inhibits LPS-induced increases in IL-1β mRNA, HIF-1α and IL-10 in macrophages. It decreases cytokine production in response to LPS in mice and prolongs survival. Synonyms: Itaconic acid 4-octyl ester; 2-Methylidene-4-octoxy-4-oxobutanoic acid. Grades: ≥98%. CAS No. 3133-16-2. Molecular formula: C13H22O4. Mole weight: 242.3. | |
5,6-Benzoflavone Quick inquiry Where to buy Suppliers range | 5,6-Benzoflavone is a polyaromatic hydrocarbon receptor agonist that induces detoxification enzymes such as P450. Synonyms: Beta-naphthoflavone; Beta-NF; 3-Phenyl-1H-benzo[f]chromen-1-one; 3-Phenyl-1H-naphtho(2,1-b)pyran-1-one. CAS No. 6051-87-2. Molecular formula: C19H12O2. Mole weight: 272.303. | |
5-Bromo-4-chloro-3-indolyl b-D-fucopyranoside Quick inquiry Where to buy Suppliers range | 5-Bromo-4-chloro-3-indolyl b-D-fucopyranoside, a ubiquitous substrate in molecular and cell biology, is utilized as a tool to indicate the presence of beta-galactosidase in the targeted cells. Upon cleavage by the enzyme, the formerly dormant substrate induces a conspicuously blue hue that unmistakably confirms gene expression and sheds light on cellular localization. Synonyms: X-b-D-Fucoside. CAS No. 17016-46-5. Molecular formula: C14H15BrClNO5. Mole weight: 392.63. | |
5-Hydroxymethyl-2',3'-di-O-isopropylidene-2-thiouridine Quick inquiry Where to buy Suppliers range | 5-Hydroxymethyl-2',3'-di-O-isopropylidene-2-thiouridine is a profoundly effective compound, meticulously utilized for research of pernicious viral infections triggered by RNA viruses. Its exceptional antiviral characteristics stem from its remarkable affinity towards targeting specific viral enzymes, unfolding a paradigm shift towards obstructing viral replication and mitigating virus-induced pathogenesis. Synonyms: 5-(hydroxymethyl)-1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; 2'-O,3'-O-Isopropylidene-5-(hydroxymethyl)-2-thiouridine; 5-(hydroxymethyl)-2',3'-O-(1-methylethylidene)-2-thio-uridine; 5-(Hydroxymethyl)-1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone. Grades: ≥95%. CAS No. 58479-71-3. Molecular formula: C13H18N2O6S. Mole weight: 330.36. | |
5'-O-Acetyl-2',3'-dideoxyinosine Quick inquiry Where to buy Suppliers range | 5'-O-Acetyl-2',3'-dideoxyinosine is an extensively utilized potent antiviral compound within the biomedical field, exhibiting impressive efficacy in research of viral infections induced by the human immunodeficiency virus (HIV). By impeding the reverse transcriptase enzyme, a pivotal factor for viral replication, this compound effectively impedes viral multiplication. Synonyms: 5'-O-Acetyldidanosine; 5'-O-Acetyl-2',3'-dideoxy-D-inosine. CAS No. 130676-58-3. Molecular formula: C12H14N4O4. Mole weight: 278.26. | |
5'-O-Acetyllamivudine Quick inquiry Where to buy Suppliers range | 5'-O-Acetyllamivudine, an exceedingly potent antiviral medication, serves as a remarkable treatment option for individuals grappling with the burdensome hepatitis B virus (HBV) infection. By skillfully obstructing the activity of the reverse transcriptase enzyme, it diligently thwarts the replication of viral DNA, thereby engendering an impediment to the proliferation of the virus. The unique structural configuration and intricate biochemical attributes of this remarkable compound provide a glimmer of hope in the realm of crafting efficacious therapies targeting HBV-induced maladies. CAS No. 151767-03-2. Molecular formula: C10H13N3O4S. Mole weight: 271.29. | |
5'-O-tert-Butyldimethylsilyl-2',3'-dideoxy-3'-fluorouridine Quick inquiry Where to buy Suppliers range | 5'-O-tert-Butyldimethylsilyl-2',3'-dideoxy-3'-fluorouridine, an indispensable compound in the biomedical field, holds immense significance. Widely employed for tackling viral infections induced by specific retroviruses, such as Human Immunodeficiency Virus (HIV), it showcases remarkable antiviral attributes through the inhibition of reverse transcriptase, a pivotal viral replication enzyme. Synonyms: 5'-O-tert-Butyldimethylsilyl-2',3'-dideoxy-3'-fluoro-D-uridine. Molecular formula: C15H25FN2O4Si. Mole weight: 344.45. | |
5'-O-Tritylinosine Quick inquiry Where to buy Suppliers range | KIN59 is a purine riboside derivative that suppresses thymidine phosphorylase (TPase). TPase is an enzyme catalyzing the reversible phosphorolysis of pyrimidine deoxynucleosides to 2-deoxy-d-ribose-1-phosphate and their respective pyrimidine bases. KIN59 noncompetitively inhibits TPase-induced angiogenesis in the chorioallantoic membrane assay. Synonyms: 5'-Trt-rI; (2R,3R,4S,5R)-9-(3,4-Dihydroxy-5-trityloxymethyl-tetrahydrofuran-2-yl)-1,9-dihydropurin-6-one; KIN-59; Inosine, 5'-O-(triphenylmethyl)-; 5'-O-(triphenylmethyl)-inosine. Grades: ≥98% by HPLC. CAS No. 4152-77-6. Molecular formula: C29H26N4O5. Mole weight: 510.55. | |
6-(2H4-Furfurylamino)purine riboside Quick inquiry Where to buy Suppliers range | 6-(2H4-Furfurylamino)purine riboside is an outstanding and discriminating antagonist, finding extensive application in the research of diverse ailments encompassing malignancy and viral infestations. It exerts its effect by precisely aiming at particular enzymatic entities, thereby inducing obstruction of anomalous cellular proliferation and impeding viral particle duplication. Synonyms: Kinetin-d4 riboside. | |
6-Amino-4-methoxy-1-(2-deoxy-a-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine Quick inquiry Where to buy Suppliers range | 6-Amino-4-methoxy-1-(2-deoxy-a-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, an efficacious antiviral agent extensively employed in biomedicine, exhibits significant inhibitory effects on viral RNA replication via selective targeting of pivotal enzymes implicated in viral replication processes. Notably, this compound showcases promising outcomes in combatting RNA virus-induced infections. Synonyms: 6-Amino-4-methoxy-1-(2-deoxy-alpha-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine; (2R,3S,5S)-5-(6-amino-4-methoxypyrazolo[3,4-d]pyrimidin-1-yl)-2-(hydroxymethyl)oxolan-3-ol. Grades: ≥95%. Molecular formula: C11H15N5O4. Mole weight: 281.27. | |
6-Aminonicotinamide Quick inquiry Where to buy Suppliers range | 6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM). 6-Aminonicotinamide is a PGD inhibitor and apoptosis inducer. Uses: Teratogens. Synonyms: 6-aminopyridine-3-carboxamide. Grades: 95 %. CAS No. 329-89-5. Molecular formula: C6H7N3O. Mole weight: 137.14. | |
6-Chloro-3-indolyl b-D-cellobioside Quick inquiry Where to buy Suppliers range | 6-Chloro-3-indolyl β-D-cellobioside, a remarkable substrate extensively utilized in the field of biomedicine, serves as a potent tool for detecting and scrutinizing the activity of β-glucosidase enzymes. Manifesting as a chromogenic substrate of utmost significance, it has found widespread usage in the investigation of inhibitory and inductive effects on β-glucosidases within diverse maladies and pharmaceutical advancements. Synonyms: Salmon-cellobioside. CAS No. 425427-87-8. Molecular formula: C20H26ClNO11. Mole weight: 491.87. | |
6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole (Triclabendazole) Quick inquiry Where to buy Suppliers range | Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.1 In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinsons disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.2,3. Group: Biochemicals. Alternative Names: 5-Chloro-6- (2, 3-dichlorophenoxy) -2- methyl thiobenzimidazole; CGA-89317, egaten; Fasinex; Triclabendazole. Grades: Highly Purified. CAS No. 68786-66-3. Pack Sizes: 25g, 50g, 100g. Molecular Formula: C14H9Cl3N2OS, Molecular Weight: 359.66. US Biological Life Sciences. | Worldwide |
7, 12-Dimethylbenz [a]anthracene Quick inquiry Where to buy Suppliers range | A highly potent carcinogen that is activated by microsomal enzymes to a diol epoxide metabolite that binds covalently to DNA in mammalian cells, leading ultimately to tumor induction. Group: Biochemicals. Grades: Highly Purified. CAS No. 57-97-6. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate - DY-480XL Quick inquiry Where to buy Suppliers range | DY-480XL, a biomedicine product specialized in biochemical studies, offers an intricate solution to understanding the dynamics of enzymatic interactions and signaling pathways. As a fluorescent analog of 2',5'-ADP, this product boasts the capability to study complex enzyme activities such as adenylate cyclase and cyclic nucleotide phosphodiesterase. Furthermore, it can delve into the intricate signaling pathways activated by extracellular receptors, which induce G protein-coupled pathways. The product's versatility renders it invaluable in the oncology research sphere, with its potential applications ranging from breast, ovarian to colon cancer. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate, labeled with DY 480XL, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C42H57N9O16P2S (free acid). Mole weight: 1037.97 (free acid). | |
9-[2'-O-Acetyl-3'-azido-3'-deoxy-5'-O-toluoyl-b-L-ribofuranosyl)-6-chloropurine Quick inquiry Where to buy Suppliers range | 9-[2'-O-Acetyl-3'-azido-3'-deoxy-5'-O-toluoyl-b-L-ribofuranosyl)-6-chloropurine, an exceptional antiviral compound, exhibits remarkable potency against diverse viral infections. Its mechanism of action involves the precise targeting of vital viral enzymes and components crucial for the life cycle of the virus. Embracing a scientific approach, this product presents a highly prospective therapeutic alternative for susceptible viral-induced diseases, exhibiting substantial efficacy validated through preclinical and clinical investigations. Synonyms: 6-Chloro-9-[2-O-acetyl-5-O-(p-toluoyl)-3-azido-3-deoxy-beta-L-ribofuranosyl]-9H-purine. Grades: ≥95%. CAS No. 2095417-30-2. Molecular formula: C20H18ClN7O5. Mole weight: 471.85. | |
9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-phenylpurine Quick inquiry Where to buy Suppliers range | 9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-phenylpurine, known for its potent antiviral properties, showcases remarkable efficacy in combating selected viral infections. By selectively inhibiting key enzymes crucial for viral RNA synthesis, this therapeutic agent effectively hampers viral replication. Groundbreaking results have been observed in the management of RNA virus-induced ailments like hepatitis C and influenza. Synonyms: 9H-Purine, 9-(3-deoxy-3-fluoro-β-D-ribofuranosyl)-6-phenyl-; (2R,3S,4S,5R)-4-fluoro-5-(hydroxymethyl)-2-(6-phenylpurin-9-yl)oxolan-3-ol. Grades: ≥95%. CAS No. 1612191-91-9. Molecular formula: C16H15FN4O3. Mole weight: 330.31. | |
9-(3-Deoxy-3-fluoro-beta-D-ribofuranosyl)purine Quick inquiry Where to buy Suppliers range | 9-(3-Deoxy-3-fluoro-beta-D-ribofuranosyl)purine is an exceptionally potent biomedical agent extensively employed to combat viral infections. With remarkable precision, it aims at impeding viral replication and dissemination. This compound exhibits immense promise in the therapeutic management of a diverse array of viral afflictions, encompassing respiratory infections, herpes, and multiple forms of viral hepatitis. Mechanistically, it exerts its effects by obstructing crucial viral enzymes indispensable for the synthesis of viral DNA/RNA, thereby impeding their capacity to proliferate and induce further harm to the host organism. Synonyms: (2R,3S,4S,5R)-4-fluoro-5-(hydroxymethyl)-2-(9H-purin-9-yl)tetrahydrofuran-3-ol; 3-Fluoronebularine; 9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-9H-Purine. Grades: ≥95%. CAS No. 124775-29-7. Molecular formula: C10H11FN4O3. Mole weight: 254.22. | |
ABC34 Quick inquiry Where to buy Suppliers range | ABC34 is an inactive control probe for JJH260 , the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). Synonyms: 1,3-dioxo-7-(4-phenoxybenzyl)hexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-methoxyphenyl)piperazine-1-carboxylate. Grades: ≥98%. CAS No. 1831135-56-8. Molecular formula: C31H33N5O6. Mole weight: 571.6. | |
Acein Quick inquiry Where to buy Suppliers range | Acein is a high-affinity angiotensin-converting enzyme (ACE) ligand with a Kd of 2.79 nM. It potentiates NMDA+ D-serine-induced dopamine release from the striatum in vivo and striatal slices in vitro. Synonyms: L-Alanine, L-prolyl-L-prolyl-L-threonyl-L-threonyl-L-threonyl-L-lysyl-L-phenylalanyl-L-alanyl-; L-Prolyl-L-prolyl-L-threonyl-L-threonyl-L-threonyl-L-lysyl-L-phenylalanyl-L-alanyl-L-alanine; H-Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala-OH. Grades: ≥95%. CAS No. 2022202-76-0. Molecular formula: C43H68N10O13. Mole weight: 933.06. | |
Acein acetate Quick inquiry Where to buy Suppliers range | Acein acetate is a high-affinity angiotensin-converting enzyme (ACE) ligand with a Kd of 2.79 nM. It potentiates NMDA+ D-serine-induced dopamine release from the striatum in vivo and striatal slices in vitro. Synonyms: H-Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala-OH.CH3CO2H; L-prolyl-L-prolyl-L-threonyl-L-threonyl-L-threonyl-L-lysyl-L-phenylalanyl-L-alanyl-L-alanine acetate. Grades: ≥95%. Molecular formula: C45H72N10O15. Mole weight: 993.11. | |
Alectinib Quick inquiry Where to buy Suppliers range | Alectinib, marketed as Alecensa, is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK) and is used to treat non-small-cell lung cancer (NSCLC). Alectinib has a low potential for interactions. While it is metabolised by the liver enzyme CYP3A4, and blockers of this enzyme accordingly increase its concentrations in the body, they also decrease concentrations of the active metabolite M4, resulting in only a small overall effect. Conversely, CYP3A4 inducers decrease alectinib concentrations and increase M4 concentrations. Interactions via other CYP enzymes and transporter proteins cannot be excluded but are unlikely to be of clinical significance. Synonyms: CH-5424802; CH5424802; CH 5424802; AF-802; RG-7853; RO5424802. Grades: ≥95%. CAS No. 1256580-46-7. Molecular formula: C30H34N4O2. Mole weight: 482.62. | |
α-Amino-hexyl-AMP Quick inquiry Where to buy Suppliers range | α-Amino-hexyl-AMP, otherwise known as 6-Aminohexyladenosine 5'-monophosphate, is an essential biological compound used in the intricate and complex synthesis of RNA and DNA. In addition, this powerful compound discloses tremendous potential to serve as an effective treatment for certain forms of cancer, as it possesses the capability to selectively dismantle and suppress the activity of tumorigenic enzymes that induce oncogenesis. With its further use as an activator of the immune system, it propels the immune response to fend off various types of viral infections and pathogens. Synonyms: α-(6-Aminohexyl)-adenosine-5'-monophosphate, Sodium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C16H27N6O7P (free acid). Mole weight: 446.40 (free acid). | |
AM-643 Quick inquiry Where to buy Suppliers range | AM-643 is an active molecular. In the Biological Tests, it can inhibit FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 5 hrs by ELISA and the activity value is 0.081μM. It can also Inhibit COX1-mediated TXB2 production in human whole blood after 30 mins by competitive enzyme immunoassay and the activity value is 25μM. Synonyms: AM-643 Free Acid; AM643 Free Acid; UNII-55668SZQ3E;3-(3-(tert-butylthio)-1-(4-(5-methoxypyrimidin-2-yl)benzyl)-5-((5-methylpyridin-2-yl)methoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid. Grades: 98%. CAS No. 1233114-22-1. Molecular formula: C36H40N4O4S. Mole weight: 642.79. | |
AMPK Signaling Agonist, F17 (4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~0.1uM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-a1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25uM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C. Group: Biochemicals. Grades: Highly Purified. CAS No. 280112-24-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Amrinone Quick inquiry Where to buy Suppliers range | Amrinone is a selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. It is a simple, non-glycoside cardiotonic agent. It provides protection against ischemia-reperfusion injury in kidney, liver, and heart. It has the ability to stimulate calcium ion influx into the cardiac cell. It is used in the treatment of congestive heart failure. It increases cardiac contractility as a vasodilator. It acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme. It is a drug that may improve the prognosis in patients with congestive heart failure. It has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). It was developed by Sanofi and has been listed. Uses: Amrinone is a simple, non-glycoside cardiotonic agent. it provides protection against ischemia-reperfusion injury in kidney, liver, and heart. it is used in the treatment of congestive heart failure. it increases cardiac contractility as a vasodilator. Synonyms: Inamrinone; Wincoram; Inocor; Cordemcura; Win-40680; Win40680; 3-Amino-5-pyridin-4-yl-1H-pyridin-2-one. Grades: 98%. CAS No. 60719-84-8. Molecular formula: C10H9N3O. Mole weight: 187.20. | |
Anacardic acid triene Quick inquiry Where to buy Suppliers range | Anacardic acid is a blanket term applied to a family of closely related compounds consisting of salicylic acid with a 15-carbon alkyl chain, which exist either in a fully saturated form or as a monoene, diene, or triene. Anacardic acid triene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid. Anacardic acid triene inhibits NADH oxidase with IC50 of 1.3 μg/ml, which is an enzyme involved in bacterial respiration. Anacardic acid triene is molluscicidal, inducing toxicity in B. glabrata (LC50 = 0.35 ppm), but is inactive against S. mansoni parasites. Synonyms: Anacardic Acid 15:3. Grades: ≥98%. CAS No. 103904-73-0. Molecular formula: C22H30O3. Mole weight: 342.47. | |
Angiotensin (1-7) Quick inquiry Where to buy Suppliers range | Angiotensin 1-7 (Ang-(1-7)) is a major active component of the renin-angiotensin system (RAS), produced from cleavage of Ang II by angiotensin-converting-enzyme type 2 (ACE2). Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity. Uses: Peptide Inhibitors. CAS No. 51833-78-4. Product ID: R1805. | |
APC 366 trifluoroacetate salt Quick inquiry Where to buy Suppliers range | APC 366 is a mast cell tryptase inhibitor with Ki of 7.1 μM for human recombinant enzyme. It is a selective inhibitor of mast cell tryptase, which has been shown to inhibit antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma. APC 366 can reduce maximum contractile response to histamine in isolated bronchial tissue from ovalbumin-sensitized guinea pigs. It can also reduce airway resistance and increases dynamic lung compliance in A. suum antigen-challenged pigs. Grades: ≥95%. Molecular formula: C22H28N6O4·xCF3COOH. Mole weight: 440.50. | |
Apricoxib Quick inquiry Where to buy Suppliers range | Apricoxib is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. Synonyms: CS-701; CS 701; CS701; TG01; TG 01; TG-01; R-109339, R 109339; R109339; Benzenesulfonamide, 4-[2-(4-ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]-. CAS No. 197904-84-0. Molecular formula: C19H20N2O3S. Mole weight: 356.44. | |
AS1940477 Quick inquiry Where to buy Suppliers range | AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent concentrations of AS1940477 that inhibited cytokine production also inhibited TNFα- and IL-1 β-induced production of IL-6, PGE(2), and MMP-3 in human synovial stromal cells. AS1940477 was also found to potently inhibit TNF production in whole blood (IC(50)=12 nM) and effectively inhibited TNFα production induced by systemically administered LPS in rats at less than 0.1mg/kg (ED(50)=0.053 mg/kg) with an anti-inflammatory effect lasting for 20h after oral administration. Overall, this study demonstrated that AS1940477 is a novel and potent p38 MAPK inhibitor and may be useful as a promising anti-inflammatory agent for treating inflammatory disorders. Synonyms: AS1940477; AS-1940477; AS 1940477. CAS No. 928344-12-1. Molecular formula: C24H22FN5O2. Mole weight: 431.47. | |
Autotaxin Inhibitor III, PF-8380 (Atx Inhibitor III, PF-8380, 6-(3-(Piperazin-1-yl)propanoyl)-benzo[d]oxazol-2(3H)-one) Quick inquiry Where to buy Suppliers range | An orally bioavailable piperazinyl benzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50=2.8 and 1.7nM for recombinant human enzyme-b isoform employing FS-3 and LPC (lysophosphatidyl choline) as substrates, respectively; 1.16 and 1.15nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101nM for human whole blood}. Displays desirable pharmacokinetics properties and efficiently blocks inflammation-induced LPA (lysophosphatidic acid) production both in plasma and at the site of inflammation by 95% in rat adjuvant-induced arthritis model (30mg/kg, p.o.).CAS No:1144035-53-9. Group: Biochemicals. Grades: Highly Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences. | Worldwide |
AZD 3988 Quick inquiry Where to buy Suppliers range | AZD 3988 is a selective and potent diacylglycerol O-acyltransferase (DGAT) enzyme inhibitor with IC50 value of 0.6 nM. It is selective for DGAT-1 over DGAT-2, cytochrome P450 enzymes and Kv11.1 (hERG). It suppresses adipose tissue TAG synthesis and triacylglyceride (TAG) plasma excursion in rats. It reduces body weight of diet-induced obese rats and may be used as a potential treatment for diabetes and other metabolic diseases. It is orally bioavailable and cell permeable. Synonyms: AZD 3988; AZD-3988; AZD3988; trans-4- [- [ [ [5- [ (3, 4-Difluorophenyl) amino] -1, 3, 4-oxadiazol-2-yl] carbonyl] amino] phenyl] cyclohexaneacetic acid. Grades: ≥98% by HPLC. CAS No. 892489-52-0. Molecular formula: C23H22F2N4O4. Mole weight: 456.44. | |
Belinostat Quick inquiry Where to buy Suppliers range | Belinostat is a hydroxamic acid-type histone deacetylase (HDAC) inhibitor. Belinostat targets HDAC enzymes to inhibit tumor cell proliferation and angiogenesis, induce apoptosis and promote cellular differentiation. Uses: Antineoplastic agents. Synonyms: Belinostat; PXD 101; Beleodaq; PDX101; PX 105684; PXD-101; PXD101; (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide. CAS No. 414864-00-9. Molecular formula: C15H14N2O4S. Mole weight: 318.347. | |
Benzamide, N-?(3-?β-?D-?ribofuranosyl-?3H-?1,?2,?3-?triazolo[4,?5-?d]?pyrimidin-?7-?yl)?- Quick inquiry Where to buy Suppliers range | Benzamide, N-(3-β-D-ribofuranosyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl) is a remarkable biomedical compound, meticulously engineered to the research of compound-resistant strains affirmed in diverse pathogen-induced infections. Employing a virtuoso strategy, it skillfully halts the propagation and sustenance of pathogens by impeding pivotal enzymes, thereby perturbing their intricate life cycle and efficaciously orchestrating disease research. CAS No. 173341-77-0. Molecular formula: C16H16N6O5. Mole weight: 372.34. | |
Bestatin hydrochloride Quick inquiry Where to buy Suppliers range | Bestatin hydrochloride is a reversible inhibitor of aminopeptidase enzymes, namely Aminopeptidase B, Aminopeptidase M (CD13), and leucine aminopeptidase (LAP3). Inhibition of these proteins by bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4). It is potentially used for cancer treatment. Uses: Peptide Inhibitors. CAS No. 65391-42-6. Product ID: R1028. | |
β-cyano-L-alanine Quick inquiry Where to buy Suppliers range | β-cyano-L-alanine is a reversible inhibitor of the H2S-synthesizing enzyme CSE. It blocks H2S synthesis in rat liver preparations with an IC50 value of 6.5 μM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H2S synthesis. Synonyms: BCA; beta-cyano-L-alanine; 3-Cyano-L-alanine; L-3-Cyanoalanine. Grades: ≥ 98% (TLC). CAS No. 6232-19-5. Molecular formula: C4H6N2O2. Mole weight: 114.1. | |
BGC 20-1531 hydrochloride Quick inquiry Where to buy Suppliers range | BGC 20-1531 hydrochloride is a potent and selective EP4 antagonist, which exhibits <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors. It has high affinity and selective with Ki of 3 nM for EP4 antagonist. BGC 20-1531 antagonizes PGE2-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA. It also reverses PGE2-induced vasorelaxation with Kb of 15.85 nM in human middle cerebral and middle meningeal arterial rings. Synonyms: BGC20-1531 HCl; BGC20-1531 hydrochloride; BGC20-1531; BGC 20-1531; BGC-20-1531; BGC201531; BGC 201531; BGC-201531; PGN 1531; PGN-1531; PGN1531. Grades: ≥98%. CAS No. 1962928-26-2. Molecular formula: C26H24N2O6S·HCl. Mole weight: 529. | |
Bifendate Quick inquiry Where to buy Suppliers range | Bifendate is a synthetic intermediate of schisandrin C, a dibenzocyclooctadiene derivative derived from lignans used in traditional medicine and also a anti-HBV drug used in the treatment of chronic hepatitis B. It has been used in some countries as a hepatoprotectant adjuvant in the treatment of liver diseases, such as chronic viral hepatitis or drug-induced hepatic damage. Uses: Cytochrome p-450 enzyme inhibitors. Synonyms: 7,7'-Dimethoxy-[4,4'-Bi-1,3-benzodioxole]-5,5'-dicarboxylic Acid 5,5'-Dimethyl Ester; DDB; Dimethyl 4,4'-Dimethoxy-5,6,5',6'-di(methylenedioxy)biphenyl-2,2'-dicarboxylate; Dimethyl dicarboxylate Biphenyl; α-DDB. Grades: 97.0%~103.0%. CAS No. 73536-69-3. Molecular formula: C20H18O10. Mole weight: 418.36. | |
Bleomycin complex (as sulfate salts) Quick inquiry Where to buy Suppliers range | Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2 and typically represent >90% of the total weight with the remainder comprising the minor analogues. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo- enzyme that induces DNA cleavage. Group: Biochemicals. Alternative Names: Blenoxane; Blexane; Bleo. Grades: Highly Purified. CAS No. 9041-93-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Brivudine Quick inquiry Where to buy Suppliers range | Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy. Overall, the gene expression changes associated with BVDU treatment result in the decrease or prevention of chemoresistance. In addition, this agent has been shown to enhance the cytolytic activity of NK-92 natural killer cells towards a pancreatic cancer cell line in vitro. Synonyms: (E)-5-(2-Bromovinyl)-2'-deoxyuridine; (E)-5-(2-Bromovinyl)deoxyuridine; (E)-5-O-(2-bromoethenyl)-2'-deoxyuridine; 5-[(1E)-2-Bromoethenyl]-2'-deoxyuridine; 5-[(E)-2-Bromoethenyl]-2'-deoxyuridine; BVDU; Brivudin; Bromovinyldeoxyuridine; Helpin. Grades: ≥98% by HPLC. CAS No. 69304-47-8. Molecular formula: C11H13BrN2O5. Mole weight: 333.14. | |
Bromoenol lactone Quick inquiry Where to buy Suppliers range | BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) with a Ki value of 180 nM. BEL induces the proteolysis of procaspase-9 and procaspase-3 and increases cleavage of poly (ADP-ribose) polymerase. BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin Ki of 636 nM. Long term treatment with BEL increased annexin-V binding to the cell surface and nuclear DNA damage. Synonyms: BEL; Haloenol lactone; HELSS. Grades: ≥95%. CAS No. 88070-98-8. Molecular formula: C16H13BrO2. Mole weight: 317.2. | |
Busulfan Impurity 1 Quick inquiry Where to buy Suppliers range | 4-Methanesulfonyloxybutanyl Methanesulfinate is a substituted Sulforaphane analogue and a potential inducer of phase II detoxifying enzyme. Synonyms: Methanesulfinic acid, 4-[(methylsulfonyl)?oxy]?butyl ester. Grades: > 95%. CAS No. 1797106-48-9. Molecular formula: C6H14O5S2. Mole weight: 230.3. | |
Calmodulin Antagonist W-7 (Actomyosin Inhibitor) (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride) Quick inquiry Where to buy Suppliers range | W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, a Protein Kinase Inhibitor, is an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities. Group: Biochemicals. Alternative Names: N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride. Grades: Molecular Biology Grade. CAS No. 61714-27-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
Canfosfamide Quick inquiry Where to buy Suppliers range | Canfosfamide hydrochloride is the hydrochloride salt of a modified glutathione analogue with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies. Synonyms: TELCYTA; TLK286; TLK 286; TLK-286. CAS No. 158382-37-7. Molecular formula: C26H40Cl4N5O10PS. Mole weight: 787.47. | |
Canfosfamide Hydrochloride Quick inquiry Where to buy Suppliers range | Canfosfamide is a modified glutathione analogue as a small-molecule antineoplastic compound with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies. Uses: Glutathione transferase inhibitor. Synonyms: Telcyta; TER 286; TLK 286; TER286; TLK286; TER-286; TLK-286; N5- ( ( (2- ( (bis (bis (2-chloroethyl) amino) phosphoryl) oxy) ethyl) sulfonyl) -D-alanyl) -N5- ( (R) -carboxy (phenyl) methyl) -L-glutamine hydrochloride. Grades: ≥98%. CAS No. 439943-59-6. Molecular formula: C26H41Cl5N5O10PS. Mole weight: 823.93. | |
(-)-Catechin gallate Quick inquiry Where to buy Suppliers range | (-)-Catechin gallate, a minor polyphenolic constituent in green tea, is used to study its cytotoxicity. It enhances Fe(2+)-induced, lipid peroxidation. It also inhibits aromatase activity, an enzyme that converts androgens to estrogen and is thought to play a role in the etiology of breast cancer. Uses: (-)-catechin gallate has been found to be probably effective in restraining tyrosine phosphorylation caused by vegf and have potential activity in the study of breast cancer. Synonyms: (-)-CG; (-)-Catechin gallate; (2S,3R)-2-(3,4-Dihydroxyphenyl)-3-(3,4,5-trihydroxybenzoyloxy)-3,4-dihydro-2H-1-benzopyran-5,7-diol; 3,4,5-Trihydroxybenzoic acid [[(2S)-2β-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran]-3α-yl] ester. Grades: >98%. CAS No. 130405-40-2. Molecular formula: C22H18O10. Mole weight: 442.37. | |
CAY10594 Quick inquiry Where to buy Suppliers range | Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. There are two mammalian isoforms of PLD, which are PLD1 and PLD2. CAY10594 is a potent phospholipase D2 inhibitor (PLD2), which also prevents the invasive migration of breast cancer cells. It ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. Synonyms: CAY 10594; CAY-10594. Grades: ≥98%. CAS No. 1130067-34-3. Molecular formula: C26H28N4O2. Mole weight: 428.5. | |
Cerulenin (2,3-Epoxy-4-oxo-7,10-dodecadienamide) Quick inquiry Where to buy Suppliers range | Antibiotic. Fatty acid synthase (FAS) inhibitor, reported to bind in equimolar ratio to B-keto-acyl- ACP synthase, thus inhibiting protein acylation. Produces metabolic effects similar to effects of leptin, but through mechanisms that are independent of, or down-stream from, both leptin and melanocortin receptors. Apoptosis inducer. Inhibitor of bacterial fatty acid synthesis (inhibits FabH, FabB and FabF condensation enzymes). Group: Biochemicals. Grades: Highly Purified. CAS No. 17397-89-6. Pack Sizes: 5mg. Molecular Formula:C12H17NO3 MOLECULAR WEIGHT: 223.3. US Biological Life Sciences. | Worldwide |
c[G(2',5')pS-A(3',5')pS], isomer 1 and isomer 2 Quick inquiry Where to buy Suppliers range | c[G(2',5')pS-A(3',5')pS] is an isomeric di-thiophosphate analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger. It is resistant against the 2'3'-cGAMP hydrolysing enzyme ENPP1, and compared to natural 2'3'-cGAMP, it exhibits higher potency in inducing IFN-β secretion from human THP1 monocytes. Grades: ≥ 95% by HPLC. CAS No. 1638242-56-4 / 1638243-00-1. Molecular formula: C20H24N10O11P2S2 (free acid). Mole weight: 706.6 (free acid). | |
CGM097 Quick inquiry Where to buy Suppliers range | CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Synonyms: CGM097; CGM-097; CGM 097; NVPCGM097; NVPCGM 097; NVPCGM-097; NVP CGM097; NVP CGM 097; NVP CGM-097. CAS No. 1313363-54-0. Molecular formula: C38H47ClN4O4. Mole weight: 659.27. |