Insulin Growth Factor Suppliers USA
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Product | Description | |
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Insulin-like Growth Factor Quick inquiry Where to buy Suppliers range | Insulin-like Growth Factors are a type of proteins with similar sequence to insulin. They function to stimulate growth as well as also possess some ability to decrease blood glucose levels. Synonyms: IGF. | |
Insulin-like growth factor-II mRNA binding protein 3 (199-207) Quick inquiry Where to buy Suppliers range | Insulin-like growth factor-II mRNA binding protein 3. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-352. | |
Insulin-like growth factor-II mRNA binding protein 3 (515-523) Quick inquiry Where to buy Suppliers range | Insulin-like growth factor-II mRNA binding protein 3. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-351. | |
2,3'-Dichloroacetophenone Quick inquiry Where to buy Suppliers range | 2,3'-Dichloroacetophenone is used as a reagent in the synthesis of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3 β (GSK-3 β). Also used as a reagent in the synthesis of benzimidazolyl pyridinones as insulin-like growth factor I (IGF-1R) kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 21886-56-6. Pack Sizes: 1g, 5g. Molecular Formula: C8H6Cl2O. US Biological Life Sciences. | Worldwide |
293 Cell Lysate, Human Insulin Treated Quick inquiry Where to buy Suppliers range | Positive control (insulin treated 293 cells) for I7661-18M, Insulin-Like Growth Factor I Receptor, phosphorylated (Tyr1316). Group: Biologicals. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
3-Benzyloxy-4-hydroxybenzaldehyde Quick inquiry Where to buy Suppliers range | A reactant used in the preparation of PDE4 and PDE7 inhibitors, insulin-like growth-factor-I receptor (IGF-IR) inhibitors and ferulic acid derivatives as xanthine oxidase inhibitors. Group: Biochemicals. Alternative Names: 4-Hydroxy-3-(phenylmethoxy)-benzaldehyde; 3-(Phenylmethoxy)-4-hydroxybenzaldehyde; 4-Hydroxy-3- (phenylmethoxy) benzaldehyde. Grades: Highly Purified. CAS No. 50773-56-3. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
AG 1024 - CAS 65678-07-1 Quick inquiry Where to buy Suppliers range | A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 65678-07-1. Pack Sizes: 1MG. Mole weight: 305.17. Catalog: AP65678071. Assay: ≥98% (HPLC). | |
AG 494 Quick inquiry Where to buy Suppliers range | AG-494 is a EGFR (epidermal growth factor receptor) kinase inhibitor with IC50 value of 0.7 μM. It is selective over ErbB2, PDGFR and insulin receptor kinase (IC50 values are 42, 6 and > 100 μM respectively). AG-494 tyrphostin also can block Cdk2 activation. Synonyms: alpha-Cyano-(3,4-dihydroxy)-N-phenylcinnamide; Tyrphostin AG-494; Tyrphostin B48. Grades: 98%. CAS No. 139087-53-9. Molecular formula: C16H12N2O3. Mole weight: 280.28. | |
AG 555 Quick inquiry Where to buy Suppliers range | AG 555 is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC50 = 0.7 μM) with 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Synonyms: AG 555; AG-555; AG555; (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)prop-2-enamide; AG 555; AG-555; alpha-cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide; N-(3'-Phenylpropyl)-3,4-dihydroxybenzylidenecyanoacetamide; N-(3-phenylpropyl)-3,4-dihydroxybenzylidene cyanoacetamide; tyrphostin AG 555; tyrphostin AG-555; tyrphostin B46. Grades: ≥98% (HPLC). CAS No. 133550-34-2. Molecular formula: C19H18N2O3. Mole weight: 322.36. | |
AGL 2263 Quick inquiry Where to buy Suppliers range | AGL 2263 is an inhibitor of the insulin-like growth factor 1 receptor (IGF-1R; IC50 = 0.43 μM). Synonyms: (E)-2-(3,4-dihydroxybenzoyl)-3-(2-oxo-3H-1,3-benzoxazol-5-yl)prop-2-enenitrile. Grades: ≥98%. CAS No. 638213-98-6. Molecular formula: C17H10N2O5. Mole weight: 322.3. | |
AP-26113 Quick inquiry Where to buy Suppliers range | AP26113 is an orally available inhibitor of receptor tyrosine kinases anaplastic lymphoma kinase (ALK) and the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. Synonyms: AP-26113; AP 26113; AP26113; (2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide; AP26113-analog; AP-26113-analog; AP 26113-analog, Brigatinib-analog. Grades: 0.98. CAS No. 1197958-12-5. Molecular formula: C26H34ClN6O2P. Mole weight: 529.01. | |
Aurintricarboxylic acid Quick inquiry Where to buy Suppliers range | Aurintricarboxylic acid acts as a histological dye and an insulin-like growth factor receptor 1 antagonist. Synonyms: 1,4-cyclohexadiene-1-carboxylic acid, 3-(bis(3-carboxy-4-hydroxyphenyl)methylen; aluminon free acid. Grades: 95%. CAS No. 4431-00-9. Molecular formula: C22H14O9. Mole weight: 422.34. | |
BMS695735 Quick inquiry Where to buy Suppliers range | BMS695735 is a benzimidazole inhibitor of the insulin-like growth factor-1 receptor. It was also found to have potent CYP3A4 inhibition. It has broad spectrum in vivo antitumor activity. Uses: Bms695735 has broad spectrum antitumor activity. Synonyms: BMS-695735; BMS 695735; BMS695735; CHEMBL459729; BDBM27888; DNC008930; 2(1H)-Pyridinone, 4-((2-(4-chloro-1H-pyrazol-1-yl)ethyl)amino)-3-(5-(1-(3-fluoropropyl)-4-piperidinyl)-7-methyl-1H-benzimidazol-2-yl)-;(3Z)-4-[2-(4-chloropyrazol-1-yl)ethylamino]-3-[6-[1-(3-fluoropropyl)piperidin-4-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one. Grades: 95%. CAS No. 1054315-48-8. Molecular formula: C26H31ClFN7O. Mole weight: 512.02. | |
BMS-754807 Quick inquiry Where to buy Suppliers range | BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. BMS-7548077 binds to IGF-1R, preventing IGF-1 ligand binding and activation of IGF-1R-mediated signaling pathways. Synonyms: BMS754807; BMS-754807; BMS 754807. Grades: 0.98. CAS No. 1001350-96-4. Molecular formula: C23H24FN9O. Mole weight: 461.505. | |
Cimdelirsen Quick inquiry Where to buy Suppliers range | Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense molecule designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients. Synonyms: ISIS 766720; ISIS-766720; ISIS766720; IONIS-GHR-LRx; all-P-ambo-5'-O-(28-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-16,16-bis{[3-({6-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]hex-yl}amino)-3-oxopropoxy]methyl}-1-hydroxy-1,10,14,21-tetraoxo-2,18-dioxa-9,15,22-triaza-1λ5-phosphaoctacosan-1-yl)-2'-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3'?5')-2'-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3'?5')-2'-O-(2-methoxyethyl)adenylyl-(3'?5')-2'-O-(2-methoxyethyl)-5-methylcytidylyl-(3'?5')-2'-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3'?5')-P-thiothymidylyl-(3'?5')-P-thiothymidylyl-(3'?5')-P-thiothymidylyl-(3'?5')-2'-deoxy-P-thioguanylyl-(3'?5')-2'-deoxy-P-thioguanylyl-(3'?5')-2'-deoxy-P-thioguanylyl-(3'?5')-P-thiothymidylyl-(3'?5')-2'-deoxy-P-thioguanylyl-(3'?5')-2'-deoxy-P-thioadenylyl-(3'?5')-2'-deoxy-P-thioadenylyl-(3'?5')-2'-O-(2-methoxyethyl)-5-methyluridylyl-(3'?5')-2'-O-(2-methoxyethyl)adenylyl-(3'?5')-2'-O-(2-methoxyethyl)-P-thioguanylyl-(3'?5')-2'-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3'?5')-2'-O-(2-methoxyethyl)adenosine. CAS No. 2131025-82-4. | |
CJC1295 Without DAC Quick inquiry Where to buy Suppliers range | CJC-1295 is a 30-amino acid peptide and a growth hormone releasing hormone (GHRH) analog. It prolongs stimulation of growth hormone (GH) and insulin-like growth factor I secretion. It also extends the half-life and bioavailability of growth-hormone-releasing hormone 1-29. Synonyms: CJC 1295; CJC1295; L-tyrosyl-D-alanyl-L-alpha-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-glutaminyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-alanyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-isoleucyl-L-leucyl-L-seryl-L-argininamide. Grades: >98%. CAS No. 863288-34-0. Molecular formula: C152H252N44O42. Mole weight: 3367.9. | |
epi-Inositol Quick inquiry Where to buy Suppliers range | epi-Inositol is a multifunctional natural compound for the research of insulin resistance and polycystic ovary syndrome (PCOS) because of its exceptional insulin-sensitizing properties. Uses: A growth factor in many plants and animals; used as a nutritional supplement; an isomer of glucose that has traditionally been considered to be a b vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. Synonyms: inositol; myo-inositol; Scyllo-inositol; epi-Inositol; Muco-Inositol; Allo-inositol; i-Inositol;meso-Inositol; Neo-inositol; D-chiro-Inositol; 1L-Chiro-inositol; D-(+)-chiro-Inositol; cis-Inositol;1D-Chiro-inositol; Myoinositol; Scyllitol; Cyclohexane-1,2,3,4,5,6-hexaol;(1r,2r,3r,4r,5r,6r)-cyclohexane-1,2,3,4,5,6-hexol; (1r,2R,3S,4r,5R,6S)-cyclohexane-1,2,3,4,5,6-hexol; 1,3,5/2,4,6-Hexahydroxycyclohexane; (1R,2R,3R,4R,5S,6S)-Cyclohexane-1,2,3,4,5,6-hexaol; 1-L-chiro-Inositol; Inositol, D-chiro-; (+)-Chiro-Inositol. CAS No. 488-58-4. Molecular formula: C6H12O6. Mole weight: 180.16. | |
Figitumumab Quick inquiry Where to buy Suppliers range | Figitumumab is a monoclonal antibody that targets the insulin-like growth factor type I receptor (IGF1R). Figitumumab binds to IGF1R, resulting in a reduction in receptor expression on tumor cells that express IGF1R and inhibition of tumor growth. Synonyms: CP-751871. CAS No. 943453-46-1. | |
IGF-1 DES1,3 Quick inquiry Where to buy Suppliers range | IGF-1 DES1,3 is a fragment of amino acids of the Insulin Growth Factor-1 DES. Synonyms: Insulin Growth Factor-1 DES. Grades: 99%. CAS No. 67763-96-6. Molecular formula: C18H32N5O7S1. Mole weight: 462.55. | |
IGF-1 LR3 Quick inquiry Where to buy Suppliers range | IGF-1 LR3 is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1). Uses: API. CAS No. 946870-92-4. Product ID: 10-101-260. | |
IGF-1 LR3 Quick inquiry Where to buy Suppliers range | IGF-1 LR3 is a lengthened analogue of human insulin-like growth factor 1 (IGF-1). Synonyms: Long R3-IGF-1; IGF-1 Long R3; Long arginine 3-IGF-1. Grades: 95%. CAS No. 946870-92-4. Molecular formula: C400H625N111O115S9. Mole weight: 9117.6. | |
IGF-I 24-41 Quick inquiry Where to buy Suppliers range | IGF-I (24-41) is amino acids 24 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions). Uses: Peptide Inhibitors. CAS No. 135861-49-3. Product ID: R1442. | |
IGF-I 24-41 Quick inquiry Where to buy Suppliers range | IGF-I 24-41 is a 24-41 amino acid fragment of insulin-like growth factor I(IGF-I). IGF-I has anabolic, antioxidant, anti-inflammatory and cell-protective properties. Synonyms: Insulin-like Growth Factor I (24-41); H-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-OH; L-tyrosyl-L-phenylalanyl-L-asparagyl-L-lysyl-L-prolyl-L-threonyl-glycyl-L-tyrosyl-glycyl-L-seryl-L-seryl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-prolyl-L-glutaminyl-L-threonine. Grades: ≥95%. CAS No. 135861-49-3. Molecular formula: C88H133N27O28. Mole weight: 2017.16. | |
IGF-I (24-41) TFA Quick inquiry Where to buy Suppliers range | IGF-I (24-41) (TFA) is amino acids 24 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions). Uses: Peptide Inhibitors. Product ID: R1440. | |
IGF-I 30-41 Quick inquiry Where to buy Suppliers range | IGF-I 30-41 is a 30-41 amino acid fragment of insulin-like growth factor I(IGF-I). IGF-I has anabolic, antioxidant, anti-inflammatory and cell-protective properties. Synonyms: Insulin-like Growth Factor I (30-41); H-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-OH; glycyl-L-tyrosyl-glycyl-L-seryl-L-seryl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-prolyl-L-glutaminyl-L-threonine. Grades: ≥95%. CAS No. 82177-09-1. Molecular formula: C51H83N19O19. Mole weight: 1266.32. | |
IGF-I 30-41 Quick inquiry Where to buy Suppliers range | IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions). Uses: Peptide Inhibitors. CAS No. 82177-09-1. Product ID: R1443. | |
IGF-I 30-41 acetate Quick inquiry Where to buy Suppliers range | IGF-I 30-41 acetate is a 30-41 amino acid fragment of insulin-like growth factor I(IGF-I). IGF-I has anabolic, antioxidant, anti-inflammatory and cell-protective properties. Synonyms: Insulin-like Growth Factor I (30-41) acetate; H-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-OH.CH3CO2H; glycyl-L-tyrosyl-glycyl-L-seryl-L-seryl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-prolyl-L-glutaminyl-L-threonine acetic acid. Grades: ≥95%. Molecular formula: C53H87N19O21. Mole weight: 1326.39. | |
IGF-I (30-41) TFA Quick inquiry Where to buy Suppliers range | IGF-I (30-41) (TFA) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions). Uses: Peptide Inhibitors. Product ID: R1441. | |
KU-55933 Quick inquiry Where to buy Suppliers range | KU-55933 is an ATM inhibitor, which blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU-55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU-55933 treatment during serum starvation triggers apoptosis in these cancer cells. Research results suggest that KU-55933 may be a novel chemotherapeutic agent targeting cancer resistant to traditional chemotherapy or immunotherapy due to aberrant activation of Akt. Furthermore, KU-55933 completely abrogates rapamycin-induced feedback activation of Akt. Combination of KU-55933 and rapamycin not only induces apoptosis, which is not seen in cancer cells treated only with rapamycin, but also shows better efficacy in inhibiting cancer cell proliferation than each drug alone. Synonyms: KU 55933; KU-55933; KU55933. CAS No. 587871-26-9. Molecular formula: C21H17NO3S2. Mole weight: 395.49. | |
KW-2450 Tosylate salt Quick inquiry Where to buy Suppliers range | KW-2450 is insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) antagonist. KW-2450 can selectively bind to and inhibit the activities of IGF-1R and IR and this may lead to the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In Apr 2013, Phase-I/II for Breast cancer and Phase-I for Solid tumours were discontinued in USA. Uses: Breast cancer; solid tumours. Synonyms: KW-2450 Tosylate salt; KW 2450 Tosylate salt; KW2450 Tosylate salt; (E)-N-(2-(2-(1H-indazol-3-yl)vinyl)-5-((4-(2-hydroxyacetyl)piperazin-1-yl)methyl)phenyl)-3-methylthiophene-2-carboxamide 4-methylbenzenesulfonate; 904899-25-8 (free base). Grades: 98%. CAS No. 1360433-93-7. Molecular formula: C35H37N5O6S2. Mole weight: 687.83. | |
Largazole Quick inquiry Where to buy Suppliers range | Largazole is a novel histone deacetylase (HDAC) inhibitor. Screening against the National Cancer Institute's 60 cell lines revealed that largazole is particularly active against several colon cancer cell types. Largazole inhibits HDACs in tumor tissue in vivo. Largazole strongly stimulated histone hyperacetylation in the tumor, showed efficacy in inhibiting tumor growth, and induced apoptosis in the tumor. This effect probably is mediated by the modulation of levels of cell cycle regulators, antagonism of the AKT pathway through insulin receptor substrate 1 down-regulation, and reduction of epidermal growth factor receptor levels. Synonyms: (+)-Largazole; S-((E)-4-((12Z,22Z,24R,5S,8S)-5-isopropyl-24-methyl-3,6,10-trioxo-24,25-dihydro-7-oxa-4,11-diaza-1(4,2),2(2,4)-dithiazolacyclododecaphane-8-yl)but-3-en-1-yl) octanethioate. CAS No. 1009815-87-5. Molecular formula: C29H42N4O5S3. Mole weight: 622.86. | |
Linsitinib Quick inquiry Where to buy Suppliers range | Linsitinib is a small-molecule dual insulin-like growth factor-1 receptor (IGF-IR) and insulin receptor (IR) kinase inhibitor. IGF-I receptor (IGF-IR) has been implicated in the promotion of tumorigenesis, metastasis and resistance to cancer therapies and thus Linsitinib may be a useful anticancer agent. Group: Biochemicals. Alternative Names: cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol; OSI 906; OSI 906AA. Grades: Highly Purified. CAS No. 867160-71-2. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
Linsitinib Quick inquiry Where to buy Suppliers range | Linsitinib, also known as OSI-906, is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. OSI-906 selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGFR-1 stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis. Synonyms: OSI-906; OSI906; OSI 906. CAS No. 867160-71-2. Molecular formula: C26H23N5O. Mole weight: 421.504. | |
LONG R3 IGF-1 (human) Quick inquiry Where to buy Suppliers range | LONG R3 IGF-1 (human) is a recombinant analog of human insulin-like growth factor-I (IGF-I). Synonyms: long R3 igf-I. CAS No. 143045-27-6. Molecular formula: C400H619N111O115S9. Mole weight: 9111.45. | |
LONG R3 IGF-1 (human) Quick inquiry Where to buy Suppliers range | LONG R3 IGF-I is a recombinant analogue of human insulin-like growth factor-I (IGF-I), specially designed to improve cell culture performance. It has higher biological activity than insulin or natural IGF-I in vitro and has been shown to significantly increase the production of recombinant protein. It is an ideal choice for research and large-scale culture systems (serum-free or low-level serum applications). Uses: API. CAS No. 143045-27-6. Product ID: 10-101-261. | |
Mecasermin Quick inquiry Where to buy Suppliers range | Mecasermin, also known as recombinant human insulin-like growth factor-1 (rhIGF-1), is a recombinant form of human insulin-like growth factor 1 (IGF-I) which is used in the long-term treatment of growth failure and short stature in children with severe primary IGF-I deficiency, for instance due to growth hormone deficiency or Laron syndrome (growth hormone insensitivity). Uses: API. CAS No. 68562-41-4. Product ID: 10-101-335. | |
MGF Quick inquiry Where to buy Suppliers range | Mechano Growth Factor, or MGF, is a peptide derived from a different sequence of insulin-like growth factor-1 (IGF-1), which plays a large role in childhood development and continues to have anabolic effects throughout adulthood. Uses: API. Product ID: 10-101-213. | |
MGF Quick inquiry Where to buy Suppliers range | Mechano growth factor (MGF) is a spliced variant of insulin-like growth factor 1 (IGF-1). IGF-1 is found in various tissues in the body including liver and muscle. Synonyms: MGF E-domain; IGF-1 EC; Mechano Growth Factor. Grades: 98%. Molecular formula: C121H199N40O40. Mole weight: 2868.19. | |
NBI 31772 Quick inquiry Where to buy Suppliers range | NBI-31772 is an insulin-like growth factor-1 binding protein inhibitor. It increases cardiomyocyte proliferation in vivo. Synonyms: NBI-31772; NBI 31772; NBI31772; 1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 374620-70-9. Molecular formula: C17H11NO7. Mole weight: 341.27. | |
Nordihydroguaiaretic acid Quick inquiry Where to buy Suppliers range | NDGA (Nordihydroguaiaretic acid), also known as masoprocol, is a naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. NDGA directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, NDGA inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrines; it may prevent leukocyte infiltration into tissues and the release of reactive oxygen species and, at higher concentrations, may also inhibit cyclooxygenase. Synonyms: 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol. Grades: > 98 %. CAS No. 500-38-9. Molecular formula: C18H22O4. Mole weight: 302.36. | |
Nordihydro Guaiaretic Acid-[d6] Quick inquiry Where to buy Suppliers range | Nordihydro Guaiaretic Acid-[d6], is the labelled analogue of Nordihydro Guaiaretic Acid. Nordihydroguaiaretic acid(NDGA), also known as masoprocol, is a naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. NDGA directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. Synonyms: Nordihydro Guaiaretic Acid D6. CAS No. 1346600-58-5. Molecular formula: C18H16D6O4. Mole weight: 308.4. | |
NVP-AEW541 Quick inquiry Where to buy Suppliers range | NVP-AEW541 is a selective inhibitor of Insulin-like growth factor 1 receptor (IGF-1R) kinase. It abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. In vivo, NVP-AEW541 inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas. Synonyms: AEW-541; AEW 541; AEW541; 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine. Grades: ≥98%. CAS No. 475488-34-7. Molecular formula: C27H29N5O. Mole weight: 439.6. | |
PEG-MGF Quick inquiry Where to buy Suppliers range | PEG-MGF is a polyethylene glycol structure attached to a larger mechano growth factor molecule. It is a derived form of the IGF-1 (insulin-like growth factor-1), which stimulates myoblasts division and allows for muscle fibers to fuse and mature. Synonyms: Pegylated MGF, PEG IGF-1 Ec. Grades: >95%. Molecular formula: C121H200N42O39. Mole weight: 2948.15. | |
PEG-MGF Quick inquiry Where to buy Suppliers range | Pegylated Mechano Growth Factor (PEG-MGF) is a derived form of the IGF-1 (insulin-like growth factor-1), which stimulates myoblasts division and allows for muscle fibers to fuse and mature. This is a process necessary for the growth of adult muscle. The distinction between IGF-1 and MGF is that MGF stimulates myoblasts division through the stimulation of different receptors. Research has demonstrated that PEG-MGF helps increase the muscle stem cell count, so that more may fuse and become part of adult muscle cells. Uses: Peptide Inhibitors. Product ID: R1829. | |
PF-4708671 Quick inquiry Where to buy Suppliers range | PF-4708671 is a novel cell-permeable inhibitor of S6K1. PF-4708671 specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 was also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 is the first S6K1-specific inhibitor to be reported and will be a useful tool for delineating S6K1-specific roles downstream of mTOR. Synonyms: PF-4708671; PF4708671; PF 4708671. Grades: 0.98. CAS No. 1255517-76-0. Molecular formula: C19H21F3N6. Mole weight: 390.40545. | |
PF-4708671 Quick inquiry Where to buy Suppliers range | PF-4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). PF-4708671 inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect on highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. Group: Biochemicals. Alternative Names: 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole; PF 4708671. Grades: Highly Purified. CAS No. 1255517-76-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
picropodophyllin Quick inquiry Where to buy Suppliers range | Picropodophyllin, also known as Picropodophyllotoxin, AXL1717 or PPP, is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells. Synonyms: AXL1717; AX-L1717; AXL 1717; PPP; Picropodophyllotoxin. Grades: >98%. CAS No. 477-47-4. Molecular formula: C22H22O8. Mole weight: 414.41. | |
Robatumumab Quick inquiry Where to buy Suppliers range | Robatumumab is a human monoclonal antibody directed against insulin-like growth factor 1 receptor (IGF-1R). Robatumumab has been used in the research of colorectal cancer. Synonyms: Sch 717454; 19D12; MK-7454. CAS No. 934235-44-6. | |
S961 Quick inquiry Where to buy Suppliers range | S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively. Uses: Peptide Inhibitors. CAS No. 1083433-49-1. Product ID: R1841. | |
SU4984 Quick inquiry Where to buy Suppliers range | SU4984 is a protein tyrosine kinase inhibitor used in cancer research with an IC50 of 10-20 μM against fibroblast growth factor receptor 1 (FGFR1). It also inhibits platelet-derived growth factor receptor and insulin receptor. Synonyms: SU-4984; SU 4984; 1-Piperazinecarboxaldehyde, 4-[4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]phenyl]-; 4-{4-[(2-Oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]phenyl}-1-piperazinecarbaldehyde; 4-(4-((2-Oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde. Grades: ≥95%. CAS No. 186610-89-9. Molecular formula: C20H19N3O2. Mole weight: 333.38. | |
SU5408 Quick inquiry Where to buy Suppliers range | A potent, selective and cell-permeable inhibitor of VEGFR2 kinase(IC50= 70 nM) with little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50 > 100 μM). Synonyms: SU-5408; SU 5408; SU5408; ethyl 2,4-dimethyl-5-[(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylate; VEGFR2 Kinase Inhibitor I; IN1018. CAS No. 15966-93-5. Molecular formula: C18H18N2O3. Mole weight: 310.35. |