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| Product | Description | |
|---|---|---|
| 2-Deoxy-2-fluoro-D-glucose | It is a substrate of hexokinase isozymes. Uses: Radiopharmaceuticals. Synonyms: 2-Deoxy-2-fluoro-D-glucopyranose; 2-Deoxy-2-fluoroglucose; FDG; Fludeoxyglucose; 2-Fluoro-2-deoxy-D-glucose. Grades: ≥95%. CAS No. 29702-43-0. Molecular formula: C6H11FO5. Mole weight: 182.15. |  |
| 2-Naphthol | 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2). Uses: Scientific research. Group: Natural products. CAS No. 135-19-3. Pack Sizes: 10 mM * 1 mL; 100 g. Product ID: HY-Y0110. |  |
| 6-Phe-cAMP | 6-Phe-cAMP is a selective stimulator of protein kinase A preferring site A of both isozymes. Synonyms: N(6)-phenyl-cAMP; N6-phenyl-cAMP; 34051-30-4; Adenosine,N-phenyl-,cyclic 3',5'-(hydrogen phosphate); sodium; (4aR,6R,7R,7aS)-6-(6-anilinopurin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol. Grades: ≥ 98% by HPLC. CAS No. 34051-30-4. Molecular formula: C16H15N5O6P · Na. Mole weight: 427.3. | |
| 8-Br-PET-cGMP | 8-Br-PET-cGMP is a stimulator of isozymes I α and I β of cGMP-dependent protein kinase, which is used as an excellent cyclic nucleotide muscle relaxants. Grades: ≥ 98% by HPLC. CAS No. 144510-04-3. Molecular formula: C18H14BrN5O7P · Na. Mole weight: 546.2. | |
| 8-NBD-cGMP | 8-NBD-cGMP is a fluorescent activator of both isozymes I α and I β of cGMP-dependent protein kinase. 8-NBD-cGMP fluoresces strongly in hydrophobic environments. Synonyms: 8- (2-[7-Nitro-4-benzofurazanyl]aminoethylthio) guanosine-3', 5'-cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 115993-88-9. Molecular formula: C18H17N9NaO10PS. Mole weight: 605.41. | |
| Aldehyde Dehydrogenase 2 from Human, Recombinant | ALDH2 is part of the aldehyde dehydrogenase family of proteins which catalyze the chemical transformation from acetaldehyde to acetic acid. ALDH2 is the second enzyme of the major oxidative pathway of alcohol metabolism. ALDH2 has 2 major liver isoforms: cytosolic and mitochondrial, which differ by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Nearly all Caucasians have 2 major isozymes, whereas roughly 50% of Orientals have only the cytosolic isozyme, omitting the mitochondrial isozyme. The extremely higher rate of acute alcohol intoxication with Orientals compared to Caucasians is due to the fact of the absence of mitochondrial... & having a molecular mass of 54.5 kda. the aldh2 is purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: ALDM; ALDHI; ALDH-E2; MGC1806; ALDH2; Aldehyde dehydrogenase mitochondrial; ALDH class 2. Purity: Greater than 90.0% as determined by SDS-PAGE. ALDH2. Mole weight: 54.5 kDa. Activity: > 0.14 units/ml. Stability: Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. ALDM; ALDHI; ALDH-E2; MGC1806; ALDH2; Aldehyde dehydrogenase mitochondrial; ALDH class 2. Cat No: NATE-0804. |  |
| Aspartate Kinase (Crude Enzyme) | Aspartate kinase (aspartokinase, aspartic kinase) is an enzyme that catalyzes the phosphorylation of the amino acid aspartate. This reaction is the first step in the biosynthesis of three essential amino acids: methionine, lysine, and threonine, known as the "aspartate family". The gene for aspartokinase is present only in microorganisms and plants; it is not present in animals, which must obtain aspartate-family amino acids in their diet. In Escherichia coli, aspartokinase is present as three independently regulated isozymes, each of which is specific to one of the three downstream biochemical pathways. This allows the independent regulation of the rates of methionine, lysin...pression by high concentrations of their end-products. Absence from animals makes these enzymes key targets for new herbicides and biocides and for improvements in nutritional value of crops. This product with the indicated enzyme activity was briefly purified from engineered E. coli. Applications: Agriculture. Group: Enzymes. Synonyms: aspartokinase; AK; β-aspartokinase; aspartic kinase. Enzyme Commission Number: EC 2.7.2.4. CAS No. 9012-50-4. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. aspartokinase; AK; β-aspartokinase; aspartic kinase. Pack: 100ml. Cat No: NATE-1827. | |
| β-N-Acetylglucosaminidase from Streptococcus pneumoniae, Recombinant | Hexosaminidase, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. Appli...Commission Number: 3.2.1.52. CAS No. 9012-33-3. β-N-Acetylhexosaminidase. Activity: > 80 units/mg protein. Storage: 2-8°C. Form: buffered aqueous solution, Solution in 20 mM Tris-HCl, pH 7.5, 25 mM NaCl. Source: E. coli. Species: Streptococcus pneumoniae. EC 3.2.1.52; 9012-33-3; hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase; β-D-hexosaminidase. Pack: vial of > 1.0 unit. Cat No: NATE-0782. | |
| BMS-582949 hydrochloride | BMS-582949 hydrochloride is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 of 13 nM. It displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases including serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms. It is a weak inhibitor of CYP3A4, with an IC50 value ranging from 18 to 40 μM based in multiple tests. It does not significantly inhibit cytochrome P450 isozymes 1A2, 2C9, 2C19, and 2D6 in vitro. It exhibited oral bioavailability values of 90% and 60% in mice and rats, respectively. It is currently under Phase II clinical trials for the treatment of inflammatory diseases. Uses: Bms-582949 hydrochloride is used for the treatment of inflammatory diseases. Synonyms: BMS 582949 hydrochloride; BMS582949 hydrochloride; BMS-582949 hydrochloride; 4-((5-((Cyclopropylamino)carbonyl)-2-methylphenyl)amino)-5-methyl-n-propylpyrrolo(2,1-f)(1,2,4)triazine-6-carboxamide. Grades: >98%. CAS No. 912806-16-7. Molecular formula: C22H27ClN6O2. Mole weight: 442.94. | |
| Dutasteride | Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GG 745; GI 198745. CAS No. 164656-23-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13613. | |
| Dutasteride (GG-745, GI-198745) | Used in the treatment of benign prostatic hyperlasia. It inhibits both isozymes of 5a-reductase. Group: Biochemicals. Alternative Names: GG-745, GI-198745. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| FR 236924 | FR 236924 is a selective PKCε activator with > 7-fold selectivity over other PKC isozymes. FR 236924 promotes glutamate release via presynaptic α7 nicotinic receptors on glutamatergic terminals in vitro and enhances cognition in vivo. It has the potential for the treatment of Alzheimer disease. Synonyms: FR 236924; FR236924; FR-236924; Dcp-LA; 2-[ (2-Pentylcyclopropyl) methyl]cyclopropaneoctanoic acid. Grades: ≥99% by HPLC. CAS No. 28399-31-7. Molecular formula: C20H36O2. Mole weight: 308.5. | |
| Furosemide Impurity F | Furosemide Impurity F is used as a carbonic anhydrase inhibitor inhibiting human, bacterial and archaeal isozymes. Synonyms: Tetrahydro Furosemide; 4-Chloro-5-sulfamoyl-N-(tetrahydrofurfuryl)anthranilic Acid; 4-Chloro-5-Sulfamoyl-2-[[((2RS)-Tetrahydrofuran-2-yl)methyl]amino]Benzoic Acid. Grades: > 95%. CAS No. 4793-38-8. Molecular formula: C12H15ClN2O5S. Mole weight: 334.78. | |
| GF-109203X | GF-109203X is a potent and highly selective PCK inhibitor, which inhibits PKC isozymes alpha, beta 1, beta 2, gamma, delta and epsilon in vitro. GF-109203X inhibited GSK-3 in vitro, when assayed either in cell lysates (IC(50) 360 nM or in GSK-3beta immunoprecipitates (IC(50) 170 nM derived from rat epididymal adipocytes. Pretreatment of adipocytes with GF-109203X (5 microM) reduced GSK-3 activity in total cell lysates, to 25.1+/-4.3% of control. Synonyms: GF109203X; GF 109203X; Bisindolylmaleimide i; GO 6850; GO-6850; GO6850; 2-[1-(3-dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide. Grades: ≥98%. CAS No. 133052-90-1. Molecular formula: C25H24N4O2. Mole weight: 412.49. | |
| Glutathione S-Transferase from E.coli, Recombinant | Glutathione S-transferases (GSTs), previously known as ligandins, comprise a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The GST family consists of three superfamilies:the cytosolic, mitochondrial, and microsomal--also known as MAPEG--proteins. Members of the GST superfamily are extremely diverse in amino acid sequence, and a large fraction of the sequences deposited in public databases are of unknown function. The Enzyme Function Initiative (EFI) is using GSTs as a model superfamily to iden...ferase. Mole weight: 26kDa. Activity: >20 units/mg. Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. Form: Sterile Filtered clear solution in Phosphate Buffered Saline pH 7.4. Source: E.coli. Species: E.coli. Glutathione S-transferases; GSTs; GST; Glutathione S-alkenetransferase; Glutathione S-alkyltransferase; Glutathione S-aralkyltransferase; Glutathione S-aryltransferase; Glutathione S-epoxidetransferase; RX:Glutathione R-transferase; EC 2.5.1.18; 50812-37-8. Cat No: NATE-1945. | |
| Glutathione S-Transferase, Recombinant | Glutathione S-transferases (GSTs), previously known as ligandins, comprise a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The GST family consists of three superfamilies:the cytosolic, mitochondrial, and microsomalalso known as MAPEGproteins. Members of the GST superfamily are extremely diverse in amino acid sequence, and a large fraction of the sequences deposited in public databases are of unknown function. The Enzyme Function Initiative (EFI) is using GSTs as a model superfamily to identify new...erase; Glutathione S-aryltransferase; Glutathione S-epoxidetransferase; RX:Glutathione R-transferase; EC 2.5.1.18; 50812-37-8. Enzyme Commission Number: EC 2.5.1.18. Purity: >90% (SDS-PAGE test). Mole weight: About 26kDa (SDS-PAGE detection). Activity: 30 u/mg. Appearance: White powder, lyophilized or colorless liquid. Storage: 4°C, store at -20°C for long-term preservation. Form: Freeze dried powder. Glutathione S-transferases; GSTs; GST; Glutathione S-alkenetransferase; Glutathione S-alkyltransferase; Glutathione S-aralkyltransferase; Glutathione S-aryltransferase; Glutathione S-epoxidetransferase; RX:Glutathione R-transferase; EC 2.5.1.18; 50812-37-8. Cat No: NATE-1141. | |
| Glycogen Synthase Kinase 3β, Histidine-tagged, from rabbit, Recombinant | Glycogen synthase kinase-3 is a serine-threonine protein kinase involved in regulation of metabolic enzymes such as glycogen synthase and ATP-Citrate lyase, and of protein phosphatase-1. It also phosphorylates brain tau-proteins, inducing an Alzheimer-like state, and protooncogene transcription factors. GSK-3β is one of two isozymes. > 90% (sds-page), recombinant, expressed in e. coli. Group: Enzymes. Synonyms: Glycogen Synthase Kinase 3β; GSK-3β; GSK3B; 9059-09-0. CAS No. 9059-09-0. Purity: > 90% (SDS-PAGE). GSK-3&beta. Stability: -20°C. Source: E. coli. Species: Rabbit. Glycogen Synthase Kinase 3β; GSK-3β; GSK3B; 9059-09-0. Cat No: NATE-0324. | |
| HDAC Inhibitor XXIII, Tubastatin A (N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide, HCl) | A cell-permeable carbazolohydroxamate compound that acts as a highly potent, reversible and active-site zinc-binding HDAC6 inhibitor with excellent selectivity among other HDAC isozymes (IC50=0.015, 0.854, 16.4uM for HDAC6, HDAC8 and HDAC1, respectively) with no activity towards HDAC2, 3, 4, 7, 9, 10 and 11 (IC50>30uM). Shown to induce a-tubulin hyperacetylation at 2.5uM, and offer complete neuroprotection in primary cortical rat neuronal cells against homocysteic acid (HCA)-induced oxidative stress at 10uM with no noticeable neurotoxicity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| [heparan sulfate]-glucosamine 3-sulfotransferase 3 | Two major substrates contain the tetrasaccharides: ? undetermined 2-sulfo-uronic acid? GlcN2S? IdoA2S? GlcN*? and ? undetermined 2-sulfo-uronic acid? GlcN2S? IdoA2S? GlcN6S*? (symbols as in 2-Carb-38) with modification of the N-unsubstituted glucosamine residue (shown with an asterisk). Modification of selected sequences containing N-sulfo-glucosamine residues cannot yet be excluded. The 3-O-sulfated heparan sulfate can be utilized by Herpes simplex virus type 1 as an entry receptor to infect the target cells. There are two isozymes, known as 3-OST-3A and 3-OST-3B, which have identical catalytic domains but are encoded by different mammalian genes. The specificity of this enzyme differs from that of the other [heparan sulfate]-glucosamine 3-sulfotransferases. It is inefficient at modifying precursors of the antithrombin binding site [in contrast to EC 2.8.2.23 ([heparan sulfate]-glucosamine 3-sulfotransferase 1)] and it does not modify glucosamine preceded by GlcA2S [unlike EC 2.8.2.29 ([heparan sulfate]-glucosamine 3-sulfotransferase 2)]. Group: Enzymes. Enzyme Commission Number: EC 2.8.2.30. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3390; [heparan sulfate]-glucosamine 3-sulfotransferase 3; EC 2.8.2.30. Cat No: EXWM-3390. | |
| Hexosaminidase 3A from Thermotoga neapolitana, Recombinant | Hexosaminidase, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. Group: Enzyme...weight: 40.6 kDa. Storage: This enzyme is shipped at room temperature but should be stored at -20 °C. Form: 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2, 0.02% sodium azide and 25% (v/v) glycerol. Source: E. coli. Species: Thermotoga neapolitana. EC 3.2.1.52; 9012-33-3; hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase; β-D-hexosaminidase; Hexosaminidase 3A. Cat No: NATE-1453. | |
| Hexosaminidase 3C from Saccharophagus degradans, Recombinant | Hexosaminidase, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. Group: Enzym...ght: 39.5 kDa. Storage: This enzyme is shipped at room temperature but should be stored at -20 °C. Form: 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2, 0.02% sodium azide and 25% (v/v) glycerol. Source: E. coli. Species: Saccharophagus degradans. EC 3.2.1.52; 9012-33-3; hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase; β-D-hexosaminidase; Hexosaminidase 3C. Cat No: NATE-1454. | |
| HIF-PHD Inhibitor II, JNJ-42041935 (HIF Prolyl Hydroxylase Inhibitor II, 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid) | A cell-permeable benzimidazolopyrazole compound that acts as an active-site binding, iron insensitive, 2-oxoglutarate competitive, reversible and potent inhibitor of PHD1, 2 and 3 isozymes (pKi=7.91, 7.29 and 7.65, respectively). Displays >100-fold selectivity over FIH (factor inhibiting hydroxylase; pIC50 ~4) and minimal affinity towards a panel of receptors, enzymes and kinases. Shown to elevate HIF-1a levels in Hep3B cells and stimulate erythropoietin secretion in mice, and reverse inflammation-induced anemia in rats (100uM/kg). Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?ClF?N?O?, Molecular Weight: 346.7. US Biological Life Sciences. | Worldwide |
| Irsogladine Maleate | Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. It inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice. It up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy. It also produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions. Synonyms: Dicloguamine maleate; MN1695; MN 1695; MN-1695. Grades: >98%. CAS No. 84504-69-8. Molecular formula: C13H11Cl2N5O4. Mole weight: 372.16. | |
| Ketohexokinase Inhibitor (N8-(Cyclopropylmethyl)-N4-(2-(methylthio)phenyl)-2-(1-piperazinyl)-pyrimido[5,4-d]pyrimidine-4,8-diamine, KHK Inhibitor) | An orally bioavailable pyrimidinopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of human hepatic KHK activity (KHK-C isoform; IC50=12nM in a transcreener ADP assay) and efficiently blocks fructose-1-phosphate secretion (IC50 ≤ 400nM in HepG2 cells). Displays ~50-fold lower potency towards metabolic kinases, namely, ribokinase, hexokinase and adenosine kinase, and minimal binding affinities to diverse receptors and ion-channels, and excellent selectivity among a panel of 31-kinases including Akt1, AMPK, CaMKI/II, InsR, IRAK4, PKA and PKCtheta (IC50 >> 10uM). Shown to minimally affect the activities of human cytochrome p450 isozymes (1A2, 2C19, 2D6, 2C9 and 3A4), and exhibit high volume of distribution and high rate of clearance in rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?S 2HCl. US Biological Life Sciences. | Worldwide |
| LY-333,531 hydrochloride (Ruboxistaurin) | An isozyme-selective inhibitor of protein kinase Cb (PKCb). Inhibits both the PKCbI (IC??=4.7 nM) and PKCbII (IC??=5.9nm) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of PKCbI and PKCbII over PKCa. Group: Biochemicals. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| MK-2 Inhibitor IV, MK-25 (MAPKAP-K2 Inhibitor IV, MK-25, 5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide, HCl) | A cell-permeable furanylcarboxamide compound that acts as a potent, reversible and non-ATP-competitive inhibitor of MK-2/MAPKAP-K2 activity (IC50=110nM; EC50=350nM for pHSP27 in IL-1b-stimulated SW1353 cells) with excellent selectivity over 150 kinases (% activity inhibition at 10uM against human CK2, Haspin, Arg and CK1y3=40, 40, 42 and >70, respectively). Shown to efficiently suppress the secretions of TNFa, IL6 (IC50=4.4 and 5.2uM in LPS-stimulated THP1 cell, respectively) and MMP-13 (IC50=5.7 and 2.2uM in IL1b-stimulated SW1353 and in primary osteoarthritis-derived chondrocytes, respectively). Exhibits desirable bioavailability and weakly inhibits a panel of cytochrome P450 isozymes (IC50>20uM for 3A4, 2D6 and 2C9). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML351 | ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC 50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 [1]. ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 847163-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111310. | |
| MS-PPOH | MS-PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes. It potently inhibits two CYP450 epoxygenases CYP2C9 and CYP2C11 (IC50 = 11-16 μM). Synonyms: N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide. Grades: ≥98%. CAS No. 206052-02-0. Molecular formula: C16H21NO4S. Mole weight: 323.4. | |
| Native Bovine β-N-Acetylglucosaminidase | This enzyme, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. Applications: Bovine ki...idase A; N-acetylhexosaminidase; β-D-hexosaminidase; 9012-33-3; EC 3.2.1.52. Enzyme Commission Number: EC 3.2.1.52. CAS No. 9012-33-3. β-N-Acetylhexosaminidase. Activity: 10-50 units/mg protein. Storage: 2-8°C. Form: ammonium sulfate suspension. Suspension in 3.2 M (NH4)2SO4, pH approx. 6.0. Source: Bovine kidney. Species: Bovine. hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase; β-D-hexosaminidase; | |
| Native Bovine Liver Alkaline Phosphatase | Alkaline phosphatases (APs) are highly ubiquitous enzymes, present in all species from bacteria to man. In humans, APs are encoded by a multi-gene family composed of four loci; i.e., tissue-nonspecific AP, also called bone/liver/kidney AP, intestinal. The sequence and complexity of the AP genes from other vertebrates and lower species are now being elucidated. The biological function of AP isozymes is still unknown. In vitro, the enzymes behave as phosphotransferases at neutral pH. The use of phosphate acceptor molecules (diethanolamine, tris, 2-amino-2-methyl-1-propanol) in the buffered substrate solutions increases the reaction rates and, thus, the sensitivity of assays based on AP determinations. Group: Enzymes. Synonyms: Alkaline phosphatase; ALP; ALKP; ALPase; Alk Phos; EC 3.1.3.1; Alkaline phosphomonoesterase; Glycerophosphatase; Phosphomonoesterase. Enzyme Commission Number: EC 3.1.3.1. CAS No. 9001-78-9. Activity: 100 U/mg protein. Storage: Store at -20° C. Form: Freeze-dried powder. Source: Bovine Liver. Species: Bovine. Alkaline phosphatase; ALP; ALKP; ALPase; Alk Phos; EC 3.1.3.1; Alkaline phosphomonoesterase; Glycerophosphatase; Phosphomonoesterase; AP. Cat No: NATE-1871. | |
| Native Bovine Protein Phosphatase 2C | Protein Phosphatase 2C is a Mg2+-dependent serine/threonine protein phosphatase with a molecular mass of 42-45 kDa, involved in regulating numerous cellular processes. It is ubiquitously expressed and has been isolated from many mammalian tissues including liver, brain, skeletal muscle, retina, and blood platelets. There are two major isotypes associated with this enzyme, 2C1 and 2C2, also known as 2Ca and 2Cb, respectively. Both isozymes appear to be equally Mg2+-dependent and respond similarly to specific substrates. Both are monomers that demonstrate ~75% sequence homology. The molecular masses are similar; 44 kDa and 42 kDa for 2C1 and 2C2, respectively. Additional Type 2C serine/threonine protein phosphatases include 2Cg, 2Cd, Wip1, and NERPP2C, many of which have multiple isozyme members. Group: Enzymes. Synonyms: Protein Phosphatase 2C; PP2C. Protein Phosphatase. Activity: ~1000 units/mg protein. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: Bovine kidney. Species: Bovine. Protein Phosphatase 2C; PP2C. Pack: vial of 1 μg. Cat No: NATE-0619. | |
| Native Canavalia ensiformis β-N-Acetylglucosaminidase | This enzyme, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. At ph 4.0, p-nit...ta;-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase; β-D-hexosaminidase; EC 3.2.1.52; 9012-33-3. Enzyme Commission Number: EC 3.2.1.52. CAS No. 9012-33-3. β-N-Acetylhexosaminidase. Activity: > 15 units/mg protein. Storage: 2-8°C. Form: ammonium sulfate suspension. Suspension in 2.5 M (NH4)2SO4, pH 7.0. Source: Canavalia ensiformis. hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-ac | |
| Native Escherichia coli Thioredoxin Reductase | Thioredoxin reductase (TrxR) is an NADPH-dependent oxidoreductase containing one FAD per subunit that reduces the active site disulfide in oxidised thioredoxin (Trx). The molecular weight of the isozymes from mammalian sources vary between 55-67 kDa as compared with 35 kDa in prokaryotes, plants or yeast. The substrate specificity of the mammalian enzyme is much broader than the prokaryotic enzyme reducing both mammalian and E. coli thioredoxins as well as well as non-disulfide substrates such selenite, lipoic acids, lipid hydroperoxides and hydrogen peroxide. Applications: Thioredoxin reductase from escherichia coli can be used in peroxidase-coupled thioredoxin system assay for assessing the peroxidase activitiy of cys-based thiol peroxidases. the product was used for determining the enzymatic activity of his6-ahp1p. Group: Enzymes. Synonyms: NADP-thioredoxi. Enzyme Commission Number: EC 1.8.1.9. CAS No. 9074-14-0. TrxR. Activity: >25 units/mg protein (Bradford). Storage: 2-8°C. Form: ammonium sulfate suspension; Suspension in 3.6 M (NH4)2SO4 containing 30 mM potassium phosphate buffer, pH 7.5, and 2 mM EDTA. Source: Escherichia coli. NADP-thioredoxin reductase; NADPH-thioredoxin reductase; thioredoxin reductase (NADPH); NADPH2:oxidized thioredoxin oxidoreductase; thioredoxin-disulfide reductase; EC 1.8.1.9; TrxR. Cat No: NATE-0718. | |
| Native Human β-N-Acetylglucosaminidase | This enzyme, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. Applications: Β-n-...etylhexosaminidase; β-D-hexosaminidase; 9012-33-3; EC 3.2.1.52. Enzyme Commission Number: EC 3.2.1.52. CAS No. 9012-33-3. β-N-Acetylhexosaminidase. Activity: 6-20 units/mg protein. Storage: 2-8°C. Form: ammonium sulfate suspension. Suspension in 2.4 M (NH4)2SO4 containing 0.15 M NaCl and 0.1 M sodium phosphate, pH 6.0. Source: Human placenta. Species: Human. hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase | |
| Native Jack Bean β-(1-2,3,4,6) Hexosaminidase, Sequencing-grade | Hexosaminidase, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. Group: Enzymes. Synonyms: β-(1-2,3,4,6) Hexosaminidase; hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhe. Hexosaminidase. Source: Jack Bean. β-(1-2,3,4,6) Hexosaminidase; hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase; β-D-hexosaminidase. Cat No: NATE-0343. | |
| Native Rat Glutathione-S-Transferase | Glutathione S-transferases (GSTs), previously known as ligandins, comprise a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The GST family consists of three superfamilies:the cytosolic, mitochondrial, and microsomal--also known as MAPEG--proteins. Members of the GST superfamily are extremely diverse in amino acid sequence, and a large fraction of the sequences deposited in public databases are of unknown function. The Enzyme Function Initiative (EFI) is using GSTs as a model superfamily to identify new GST functions. Group: Enzymes. Synonyms: Glutathione S-transferases; GSTs; GST; Glutathione S-alkenetransferase; Glutathione S-alkyltransferase; Glutathione S-aralkyltransferase; Glutathione S-aryltransferase;. Enzyme Commission Number: EC 2.5.1.18. CAS No. 50812-37-8. Purity: Purified. Glutathione S-Transferase. Activity: > 10 U/mg. Storage: -20°C. Form: Lyophilized. Source: Rat Liver. Species: Rat. Glutathione S-transferases; GSTs; GST; Glutathione S-alkenetransferase; Glutathione S-alkyltransferase; Glutathione S-aralkyltransferase; Glutathione S-aryltransferase; Glutathione S-epoxidetransferase; RX:Glutathione R-transferase; EC 2.5.1.18; 50812-37-8. Cat No: NATE-0327. | |
| Native Rat Protein Kinase C Catalytic Subunit | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the second family are phospholipid-dependent but Ca2+-independent, and include PKCδ, ε, η, and &theta. Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and &Iota. Does not require ca2+ or phosphatidylserine for its activity. Group: Enzymes. Synonyms: PKC-M, PKM; PKCM; Protein Kinase C Catalytic Subunit. Purity: > 90% (SDS-PAGE). PKC. Activity: > 800 units/mg protein. Stability: -70°C. Source: rat brain. Species: Rat. PKC-M, PKM; PKCM; Protein Kinase C Catalytic Subunit. Pack: vial of 200 ng. Cat No: NATE-0578. | |
| Native Rat Thioredoxin Reductase | Thioredoxin reductase (TrxR) is an NADPH-dependent oxidoreductase containing one FAD per subunit that reduces the active site disulfide in oxidised thioredoxin (Trx). The molecular weight of the isozymes from mammalian sources vary between 55-67 kDa as compared with 35 kDa in prokaryotes, plants or yeast. The substrate specificity of the mammalian enzyme is much broader than the prokaryotic enzyme reducing both mammalian and E. coli thioredoxins as well as well as non-disulfide substrates such selenite, lipoic acids, lipid hydroperoxides and hydrogen peroxide. Applications: Thioredoxin reductase from rat liver can be used for studying the uptake and reduction of a-lipoic acid... NADP-thioredoxin reductase; NADPH-thioredoxin reductase; thioredoxin reductase (NADPH); NADPH2:oxidized thioredoxin oxidoreductase; thioredoxin-disulfide reductase; EC 1.8.1.9; TrxR; 9074-14-0. Enzyme Commission Number: EC 1.8.1.9. CAS No. 9074-14-0. TrxR. Activity: > 100 units/mg protein (Bradford). Storage: -20°C. Form: buffered aqueous glycerol solution; Solution in 50 mM Tris-HCl, pH 7.5, 300 mM NaCl, 1 mM EDTA, and 10% glycerol. Source: Rat liver. Species: Rat. NADP-thioredoxin reductase; NADPH-thioredoxin reductase; thioredoxin reductase (NADPH); NADPH2:oxidized thioredoxin oxidoreductase; thioredoxin-disulfide reductase; EC 1.8.1.9; TrxR; 9074-14-0. Cat No: NATE-0713. | |
| nephthenol synthase | Requires Mg2+. Two isozymes with this activity were isolated from the bacterium Streptomyces sp. SANK 60404. The enzyme encoded by the DtcycA gene also produces cembrene C (see EC 4.2.3.148, cembrene C synthase), while the enzyme encoded by the DtcycB gene also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.150, cembrene A synthase, and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase). Group: Enzymes. Synonyms: DtcycA (gene name); DtcycB (gene name). Enzyme Commission Number: EC 4.2.3.149. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5163; nephthenol synthase; EC 4.2.3.149; DtcycA (gene name); DtcycB (gene name). Cat No: EXWM-5163. | |
| p38 MAP Kinase Inhibitor XI (4-(2,4-Difluorophenyl)-8-(2-methylphenyl)-1,7-naphthyridine-7-oxide, 4-(2,4-Difluorophenyl)-8-o-tolyl-1,7-naphthyridine-7-oxide) | A cell-permeable naphthyridine N-oxide compound that acts as a potent, reversible p38alpha MAP kinase inhibitor (IC50 = 68nM) and exhibits excellent selectivity among 54-kinases. It acts on the ATP-binding site plus an adjacent hydrophobic pocket. Exhibits desirable ADME (Absorption, Distribution, Metabolism, and Excretion) profile with good microsomal stability, low toxicity, and low reactivity towards cytochrome P450 isozymes. Shown to inhibit lipopolysaccharide-induced TNF-alpha production in a dose-dependent manner (ED50 of 0.5mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Panobinostat (LBH-589, LBH589, LBN-589, NVP-LBH589) | Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumor cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12nm, respectively. And to A2780 proliferation, IC50 value is 4.6±1.8nm. Group: Biochemicals. Grades: Highly Purified. CAS No. 404950-80-7. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| PET-cGMP | PET-cGMP is a potent stimulator of isozymes I α and I ß of cGMP-dependent protein kinase. Synonyms: ?- Phenyl- 1, N2-ethenoguanosine- 3', 5'-cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 78080-27-0. Molecular formula: C18H15N5O7P · Na. Mole weight: 467.3. | |
| PPOH | PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes. Synonyms: 6-(2-propargyloxyphenyl)hexanoic acid. Grades: ≥99%. CAS No. 206052-01-9. Molecular formula: C15H18O3. Mole weight: 246.3. | |
| Protein kinase Cα isozyme human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the second...third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and &Iota. > 70% (sds-page), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution. Group: Enzymes. Synonyms: PRKCA; protein kinase C, alpha; PKCA; protein kinase C alpha type; PKC-A; PKCα; AAG6; PKC-alpha; PRKACA. Purity: > 70% (SDS-PAGE). PKC. Mole weight: mol wt 80-81 kDa by SDS-PAGE. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: baculovirus infected insect cells. Species: Human. PRKCA; protein kinase C, alpha; PKCA; protein kinase C alpha type; PKC-A; PKCα; AAG6; PKC-alpha; PRKACA. Cat No: NATE-0574. | |
| Protein Kinase CβII isozyme from human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the sec... esters and include PKCξ, μ, and &Iota. Group: Enzymes. Synonyms: PRKCB; PKCB; PRKCB1; PRKCB2; protein kinase C, beta 1; protein kinase C beta type; PKC-beta; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: >95% (SDS-PAGE). PKC. Mole weight: calculated mol wt 76.9 kDa; mol wt 80 kDa by SDS-PAGE. Storage: -70°C. Form: buffered aqueous glycerol solution; Solution in 20 mM HEPES, pH 7.4; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 100 mM NaCl, 0.05% Triton X-100, and 50% glycerol. Source: Baculovirus infected insect cells. Species: Human. PRKCB; PKCB; PRKCB1; PRKCB2; protein kinase C, beta 1; protein kinase C beta type; PKC-beta; EC 2.7.1.37. Cat No: NATE-0622. | |
| Protein Kinase CβI isozyme from human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the sec...ted by either DAG or phorbol esters and include PKCξ, μ, and &Iota. Group: Enzymes. Synonyms: PRKCB; PKCB; PRKCB1; PRKCB2; protein kinase C, beta 1; protein kinase C beta type; PKC-beta; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: > 95% (SDS-PAGE). PKC. Mole weight: apparent mol wt 79-80 kDa. Storage: -70°C. Form: buffered aqueous glycerol solution; Solution in 20 mM HEPES, pH 7.4; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 100 mM NaCl, 0.05% Triton X-100, and 50% glycerol. Source: Baculovirus infected insect cells. Species: Human. PRKCB; PKCB; PRKCB1; PRKCB2; protein kinase C, beta 1; protein kinase C beta type; PKC-beta; EC 2.7.1.37. Cat No: NATE-0621. | |
| Protein Kinase Cδ isozyme from human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the sec...DAG or phorbol esters and include PKCξ, μ, and &Iota. Group: Enzymes. Synonyms: PRKCD; protein kinase C, delta; protein kinase C delta type; ALPS3; CVID9; MAY1; PKCD; nPKC-delta; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: >95% (SDS-PAGE). PKC. Mole weight: mol wt 74-79 kDa by SDS-PAGE. Storage: -70°C. Form: buffered aqueous glycerol solution; Solution in 20 mM HEPES, pH 7.4; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 100 mM NaCl, 0.05% Triton X-100, and 50% glycerol. Source: Baculovirus infected insect cells. Species: Human. PRKCD; protein kinase C, delta; protein kinase C delta type; ALPS3; CVID9; MAY1; PKCD; nPKC-delta; EC 2.7.1.37. Cat No: NATE-0623. | |
| Protein Kinase Cε isozyme human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the secon...tein kinase C, epsilon; protein kinase C epsilon type; PKCE; nPKC-epsilon; Ca2+-activated phospholipid-dependent serine-threonine kinase, ε isozyme human; PKCε human; PKCε; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: >95% (SDS-PAGE). PKC. Mole weight: apparent mol wt 89-96 kDa. Storage: -70°C. Form: buffered aqueous glycerol solution. Source: baculovirus infected insect cells. Species: Human. PRKCE; protein kinase C, epsilon; protein kinase C epsilon type; PKCE; nPKC-epsilon; Ca2+-activated phospholipid-dependent serine-threonine kinase, ε isozyme human; PKCε human; PKCε; EC 2.7.1.37. Cat No: NATE-0575. | |
| Protein Kinase Cη isozyme human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the second ...nd include PKCξ, μ, and &Iota. > 90% (sds-page), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution. Group: Enzymes. Synonyms: PRKCH; Ca2+-activated phospholipid-dependent serine-threonine kinase η isozyme human; PKCη human; PKCH; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: > 90% (SDS-PAGE). PKC. Mole weight: mol wt 82-84 kDa by SDS-PAGE. Storage: -70°C. Form: buffered aqueous glycerol solution. Source: baculovirus infected insect cells. Species: Human. PRKCH; Ca2+-activated phospholipid-dependent serine-threonine kinase η isozyme human; PKCη human; PKCH; EC 2.7.1.37. Cat No: NATE-0576. | |
| Protein kinase Cγ isozyme from human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the sec...vated by either DAG or phorbol esters and include PKCξ, μ, and &Iota. Group: Enzymes. Synonyms: PRKCG; protein kinase C, gamma; protein kinase C gamma type; PKC-gamma; PKCC; PKCG; SCA14; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: >95% (SDS-PAGE). PKC. Mole weight: mol wt 77-84 kDa by SDS-PAGE. Storage: -70°C. Form: buffered aqueous glycerol solution; Solution in 20 mM HEPES, pH 7.4; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 250 mM NaCl, 0.05% Triton X-100, and 50% glycerol. Source: Baculovirus infected insect cells. Species: Human. PRKCG; protein kinase C, gamma; protein kinase C gamma type; PKC-gamma; PKCC; PKCG; SCA14; EC 2.7.1.37. Cat No: NATE-0624. | |
| Protein Kinase CΙ, Active human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the second...activated by either DAG or phorbol esters and include PKCξ, μ, and &Iota. Recombinant, expressed in e. coli, > 85% (sds-page), buffered aqueous glycerol solution. Applications: Kinase activity is measured as the molar amount of phosphate incorporated into the crebtide substrate peptide per minute per mg protein at 30°c using a final concentration of 50 μm [32p] atp. Group: Enzymes. Synonyms: PKCL; Protein Kinase C Lambda/Iota; PKC&Iota. Purity: > 85% (SDS-PAGE). PKC. Mole weight: apparent mol wt ~98 kDa. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: E. coli. Species: Human. PKCL; Protein Kinase C Lambda/Iota; PKC&Iota. Cat No: NATE-0577. | |
| Protein Kinase Cζ isozyme from human, Recombinant | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and &gamma. Members of the seco...Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and &Iota. Group: Enzymes. Synonyms: PRKCZ; protein kinase C, zeta; protein kinase C zeta type; PKC2; PKC-ZETA; EC 2.7.1.37. Enzyme Commission Number: EC 2.7.1.37. Purity: > 75% (SDS-PAGE). PKC. Mole weight: mol wt 76-80 kDa by SDS-PAGE. Storage: -70°C. Form: buffered aqueous solution; Solution in 20 mM HEPES, pH 7.5; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 250 mM NaCl, 0.05% Triton X-100, and 50% glycerol. Source: Baculovirus infected insect cells. Species: Human. PRKCZ; protein kinase C, zeta; protein kinase C zeta type; PKC2; PKC-ZETA; EC 2.7.1.37. Cat No: NATE-0625. | |
| rac erythro-9-(2-Hydroxy-3-nonyl)adenine, Hydrochloride (EHNA) | A potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does ot inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM). Group: Biochemicals. Alternative Names: EHNA. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Reboxetine | Reboxetine, also called as Vestra, 2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate, exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine. Ti is a selective norepinephrine reuptake inhibitor used in the treatment of clinical depression, panic disorder and ADD/ADHD which has been approved for treatment of major depression. In vitro: it inhibits noradrenaline reuptake in vitro to a similar extent to the tricyclic antidepressant desmethylimipramine and does not inhibit the activity of the following isozymes of cytochrome P450: CYP1A2, CYP2C9, CYP2C19, and CYP2E1; In vivo: Reboxetine does not affect dopamine or serotonin reuptake and it has low in vivo and in vitro affinity for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors.Besides, it inhibits both CYP2D6 and CYP3A4 with low binding affinities, but has shown no effect on the in vivo clearance of drugs metabolized by these enzymes. Inhibits (±)-epibatidine-induced Ca(2+) influx in human (h) muscle embryonic (hα1β1γδ) and adult (hα1β1εδ) AChRs in a non-competitive manner , with potencies IC50= 3.86±0.49 and 1.92±0.48 μM, respectively. Uses: A selective norepinephrine reuptake inhibitor used in the treatment of clinical depression, panic disorder and add/adhd, it has been approved for treatment of major depression. Synonyms: Norebox; 2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate; Morpholine, 2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-, (2R)-rel-; (R,R)-Reboxetine. Grades: ≥ 95.0%. CAS No. 98769-81-4. Molecular formula: C19H23NO3. Mole weight: 313.39. | |
| SB 216763 (SB216763, SB-216763, SCHEMBL30251) | SB 216763 is a potent and selective ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK-3), including the alpha and beta isozymes. It displays neuroprotectant properties and stimulates glycogen synthesis in liver cells. SB 216763 is reported to be used to maintain the undifferentiated state of mouse embryonic stem cells. Group: Biochemicals. Alternative Names: 3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione. Grades: Highly Purified. CAS No. 280744-09-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Sotrastaurin | Sotrastaurin, also known as AEB-701, is an orally available pan-protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities. Sotrastaurin inhibits both T- and B-cell activations via PKC theta and beta isozymes, respectively. Both PKCs are important in the activation of nuclear factor-kappaB (NF-kB). Inhibition of PKC beta in B-cells results in prevention of NF-kB-mediated signaling and down regulation of NF-kB target genes. This may eventually lead to an induction of G1 cell cycle arrest and tumor cell apoptosis in susceptible tumor cells. This agent may act synergistically with other chemotherapeutic agents. PKC, a family of serine/threonine protein kinases overexpressed in certain types of cancer cells, is involved in cell differentiation, mitogenesis, inflammation, and the activation and survival of lymphocytes. Synonyms: AEB-071; AEB071; AEB 071. Grades: >98%. CAS No. 425637-18-9. Molecular formula: C25H22N6O2. Mole weight: 438.491. | |
| SW-100 | SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC 50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2126744-35-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-115475. | |
| Terpendole C | Inhibitor for Acyl-CoA, cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2, Tremorgenic and Cholesteryl ester (CE) synthesis. Group: Biochemicals. Grades: Highly Purified. CAS No. 156967-65-6. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Terpendole C | Isolated from Albophoma yamanashiensis. An acyl-CoA:cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2 inhibitor. Also acts as a tremorgen and cholesteryl ester (CE) synthesis inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 156967-65-6. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| Trk Inhibitor III, GNF-5837 ( (Z) -1- (3- ( (3- ( (1H-Pyrrol-2-yl) methylene) -2-oxoindolin-6-yl) amino) -4-methylphenyl) -3- (2-fluoro-5- (trifluoromethyl) phenyl) urea) | An orally bioavailable oxindole compound that and acts as a potent, reversible and type II DFG-out inhibitor of pan-Trk activity (IC50=8 and 12nM for TrkA and TrkB). Shown to target Trk (tropomyosin receptor kinase) ATP binding cleft and an immediately adjacent hydrophobic pocket. Preferentially arrests the proliferation of Ba/F3 cells fused with Tel-TrkA, Tel-TrkB and Tel-TrkC (IC50=11, 9 and 7nM, respectively) and in Ba/F3 and RIE cells expressing both TrkA and NGF (IC50=42 and 17nM, respectively) over Mo7e-c-Kit and Rat-A10-PDGFR (IC50=1 and 0.5uM) and Ba/F3-Tel-R and wt-Ba/F3 cells (IC50=3.0 and 5.6uM). Displays ~100-fold greater selectivity among a panel of 59 closely related kinases and in 33 cellular kinase assays. Weakly active against relevant cytochrome P450 isozymes and hERG channel, and exhibit adequate microsomal stability, pharmacokinetic profile and efficacy in mice and rats. Suppresses tumor growth in a mouse RIE-TrkAmNGF xenograft model (50mg/kg, p.o.). Group: Biochemicals. Grades: Highly Purified. CAS No. 1033769-28-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Tubastatin A | Tubastatin A is selective at all isozymes except HDAC8 and maintains over 1000-fold selectivity against all isoforms excluding HDAC8, where it has approximately 57-fold selectivity. Grades: >98%. CAS No. 1252003-15-8. Molecular formula: C20H21N3O2. Mole weight: 335.4. | |
| Tubastatin A HCl salt | Tubastatin A is a potent and selective HDAC6 inhibitor. Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM. Grades: 0.98. CAS No. 1310693-92-5. Molecular formula: C20H22ClN3O2. Mole weight: 371.865. | |
| Vibralactone D | Vibralactone D is isolated from Boreostereum vibrans and exhibits weak inhibitory effect against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD). Synonyms: (1S,5R,6S)-6-hydroxy-5-(3-methylbut-2-enyl)-3-oxabicyclo[3.2.1]octan-4-one; 3-Oxabicyclo[3.2.1]octan-2-one, 7-hydroxy-1-(3-methyl-2-buten-1-yl)-, (1R,5S,7S)-. Grades: ≥98%. CAS No. 1251748-32-9. Molecular formula: C12H18O3. Mole weight: 210.27. | |
| 1-Bromo-3,3,3-trifluoroacetone | 1-Bromo-3,3,3-trifluoroacetone is used to covalently modify cysteine-390 in the concentrated substrate of the supernatant isozyme of pig heart aspartate transaminase (I). Group: Biochemicals. Grades: Highly Purified. CAS No. 431-35-6. Pack Sizes: 25g, 100g. Molecular Formula: C3H2BrF3O, Molecular Weight: 190.95. US Biological Life Sciences. | Worldwide |
| 4-N3-PET-8-Br-cGMP | 4-N3-PET-8-Br-cGMP is an analogue used for photoaffinity labelling of cGMP-responsive receptors, and an isozyme-selective activator of cGMP-dependent protein kinase I α and &beta. Synonyms: β- (4- Azidophenyl)- 1, N2- etheno- 8- bromoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 97% by HPLC. Molecular formula: C18H13BrN8O7P · Na. Mole weight: 587.2. | |
| 7-O-[2- (1, 3-Dioxanyl) ethyl]daidzein (7-O-[2-(1,3-Dioxanyl)ethyl]-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) | A potent inhibitor of MOA and aldehyde dehydrogenase isozyme (ALDH2). Group: Biochemicals. Alternative Names: 7-O-[2-(1,3-Dioxanyl)ethyl]-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 7-O-Ethyldaidzein (7-Ethoxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) | A potent inhibitor of MOA and aldehyde dehydrogenase isozyme (ALDH2). Group: Biochemicals. Alternative Names: 7-Ethoxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 7-O-w-Bromopropyldaidzein (7-O-(3-Bromopropyl)-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) | A potent inhibitor of MOA and aldehyde dehydrogenase isozyme (ALDH2). Group: Biochemicals. Alternative Names: 7-O-(3-Bromopropyl)-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 8-APT-cGMP | 8-APT-cGMP is an isozyme-selective stimulator of cGMP-dependent protein kinase I a with a prenference for type I a over I by a factor of 200. Synonyms: 8- (2- Aminophenylthio)guanosine- 3', 5'- monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 144509-87-5. Molecular formula: C16H16N6O7PS · Na. Mole weight: 490.4. | |
| Akt Inhibitor, Isozyme-selective (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2) | Cell-permeable. A potent and selective inhibitor of Akt1/Akt2 activity (IC?? = 58nM (Akt1), 210nM (Akt2) and 2.12uM (Akt3) in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
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