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Product | Description | |
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Akt Inhibitor, Isozyme-selective (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2) Quick inquiry Where to buy Suppliers range | Cell-permeable. A potent and selective inhibitor of Akt1/Akt2 activity (IC?? = 58nM (Akt1), 210nM (Akt2) and 2.12uM (Akt3) in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Akti-1/2) Quick inquiry Where to buy Suppliers range | A cell-permeable, reversible, potent, and selective inhibitor of Akt1/Akt2 activity (IC50=58nM, 210nM, and 2.12uM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50uM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation / activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 Quick inquiry Where to buy Suppliers range | Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a cell-permeable, reversible inhibitor of Akt1/Akt2 (IC50 = 58 nM, 210 nM, & 2.12 μM for Akt1, Akt2, and Akt3, respectively). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 612847-09-3. Pack Sizes: 1MG, 5MG. Mole weight: 551.64. Catalog: AP612847093. Assay: ≥95% (HPLC). | |
Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 Quick inquiry Where to buy Suppliers range | The Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 2MG. Mole weight: 653.82. Catalog: IAR42415221. Assay: ≥97% (mixture of regioisomers, HPLC). | |
Akt Inhibitor XII, Isozyme-Selective, Akti-2 Quick inquiry Where to buy Suppliers range | The Akt Inhibitor XII, Isozyme-Selective, Akti-2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 2MG. Mole weight: 637.77. Catalog: IAR42415220. Assay: ≥97% (mixture of regioisomers, HPLC). | |
Akt Inhibitor XV, Isozyme-Selective Quick inquiry Where to buy Suppliers range | The Akt Inhibitor XV, Isozyme-Selective controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 2MG. Mole weight: 539.63. Catalog: IAR42415223. Assay: ≥97% (HPLC). | |
InSolution Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 Quick inquiry Where to buy Suppliers range | The Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 551.64. Catalog: IAR42415217. Assay: ≥95% (HPLC). | |
Lysozyme C, spleen isozyme Quick inquiry Where to buy Suppliers range | Lysozyme C, spleen isozyme is found in Equus caballus (Horse). Lysozyme C is capable of both hydrolysis and transglycosylation and it also shows a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides. Synonyms: 1,4-beta-N-acetylmuramidase C. | |
Lysozyme C, spleen isozyme Quick inquiry Where to buy Suppliers range | Lysozyme C, spleen isozyme. Uses: Antimicrobial Peptides. Product ID: AF2273. | |
1-Bromo-3,3,3-trifluoroacetone Quick inquiry Where to buy Suppliers range | 1-Bromo-3,3,3-trifluoroacetone is used to covalently modify cysteine-390 in the concentrated substrate of the supernatant isozyme of pig heart aspartate transaminase (I). Group: Biochemicals. Grades: Highly Purified. CAS No. 431-35-6. Pack Sizes: 25g, 100g. Molecular Formula: C3H2BrF3O, Molecular Weight: 190.95. US Biological Life Sciences. | Worldwide |
2-Deoxy-2-fluoro-D-glucose Quick inquiry Where to buy Suppliers range | It is a substrate of hexokinase isozymes. Uses: Radiopharmaceuticals. Synonyms: 2-Deoxy-2-fluoro-D-glucopyranose; 2-Deoxy-2-fluoroglucose; FDG; Fludeoxyglucose; 2-Fluoro-2-deoxy-D-glucose. Grades: ≥95%. CAS No. 29702-43-0. Molecular formula: C6H11FO5. Mole weight: 182.15. | |
4-N3-PET-8-Br-cGMP Quick inquiry Where to buy Suppliers range | 4-N3-PET-8-Br-cGMP is an analogue used for photoaffinity labelling of cGMP-responsive receptors, and an isozyme-selective activator of cGMP-dependent protein kinase I α and &beta. Synonyms: β- (4- Azidophenyl)- 1, N2- etheno- 8- bromoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 97% by HPLC. Molecular formula: C18H13BrN8O7P · Na. Mole weight: 587.2. | |
6-Phe-cAMP Quick inquiry Where to buy Suppliers range | 6-Phe-cAMP is a selective stimulator of protein kinase A preferring site A of both isozymes. Synonyms: N(6)-phenyl-cAMP; N6-phenyl-cAMP; 34051-30-4; Adenosine,N-phenyl-,cyclic 3',5'-(hydrogen phosphate); sodium; (4aR,6R,7R,7aS)-6-(6-anilinopurin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol. Grades: ≥ 98% by HPLC. CAS No. 34051-30-4. Molecular formula: C16H15N5O6P · Na. Mole weight: 427.3. | |
7-O-[2- (1, 3-Dioxanyl) ethyl]daidzein (7-O-[2-(1,3-Dioxanyl)ethyl]-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) Quick inquiry Where to buy Suppliers range | A potent inhibitor of MOA and aldehyde dehydrogenase isozyme (ALDH2). Group: Biochemicals. Alternative Names: 7-O-[2-(1,3-Dioxanyl)ethyl]-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
7-O-Ethyldaidzein (7-Ethoxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) Quick inquiry Where to buy Suppliers range | A potent inhibitor of MOA and aldehyde dehydrogenase isozyme (ALDH2). Group: Biochemicals. Alternative Names: 7-Ethoxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
7-O-w-Bromopropyldaidzein (7-O-(3-Bromopropyl)-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) Quick inquiry Where to buy Suppliers range | A potent inhibitor of MOA and aldehyde dehydrogenase isozyme (ALDH2). Group: Biochemicals. Alternative Names: 7-O-(3-Bromopropyl)-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
8-APT-cGMP Quick inquiry Where to buy Suppliers range | 8-APT-cGMP is an isozyme-selective stimulator of cGMP-dependent protein kinase I a with a prenference for type I a over I by a factor of 200. Synonyms: 8- (2- Aminophenylthio)guanosine- 3', 5'- monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 144509-87-5. Molecular formula: C16H16N6O7PS · Na. Mole weight: 490.4. | |
8-Br-PET-cGMP Quick inquiry Where to buy Suppliers range | 8-Br-PET-cGMP is a stimulator of isozymes I α and I β of cGMP-dependent protein kinase, which is used as an excellent cyclic nucleotide muscle relaxants. Grades: ≥ 98% by HPLC. CAS No. 144510-04-3. Molecular formula: C18H14BrN5O7P · Na. Mole weight: 546.2. | |
8-NBD-cGMP Quick inquiry Where to buy Suppliers range | 8-NBD-cGMP is a fluorescent activator of both isozymes I α and I β of cGMP-dependent protein kinase. 8-NBD-cGMP fluoresces strongly in hydrophobic environments. Synonyms: 8- (2-[7-Nitro-4-benzofurazanyl]aminoethylthio) guanosine-3', 5'-cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 115993-88-9. Molecular formula: C18H17N9NaO10PS. Mole weight: 605.41. | |
BMS-582949 hydrochloride Quick inquiry Where to buy Suppliers range | BMS-582949 hydrochloride is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 of 13 nM. It displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases including serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms. It is a weak inhibitor of CYP3A4, with an IC50 value ranging from 18 to 40 μM based in multiple tests. It does not significantly inhibit cytochrome P450 isozymes 1A2, 2C9, 2C19, and 2D6 in vitro. It exhibited oral bioavailability values of 90% and 60% in mice and rats, respectively. It is currently under Phase II clinical trials for the treatment of inflammatory diseases. Uses: Bms-582949 hydrochloride is used for the treatment of inflammatory diseases. Synonyms: BMS 582949 hydrochloride; BMS582949 hydrochloride; BMS-582949 hydrochloride; 4-((5-((Cyclopropylamino)carbonyl)-2-methylphenyl)amino)-5-methyl-n-propylpyrrolo(2,1-f)(1,2,4)triazine-6-carboxamide. Grades: >98%. CAS No. 912806-16-7. Molecular formula: C22H27ClN6O2. Mole weight: 442.94. | |
Cilostamide Quick inquiry Where to buy Suppliers range | Cilostamide is a selective and specific inhibitor of type III phosphodiesterase (PDE3). It shows moderate selectivity for PDE3A isozyme and PDE3B. It increases intracellular cAMP and inhibits ADP-induced platelet aggregation. It has an antithrombotic effect. Uses: Phosphodiesterase inhibitors. Synonyms: Cilostamide; OPC 3689; OPC-3689; OPC3689; N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide; 6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one. CAS No. 68550-75-4. Molecular formula: C20H26N2O3. Mole weight: 342.44. | |
CP640186 HCl Quick inquiry Where to buy Suppliers range | CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431. Synonyms: CP640186; CP 640186. Grades: 0.98. CAS No. 591778-70-0. Molecular formula: C30H36ClN3O3. Mole weight: 522.09. | |
Dutasteride (GG-745, GI-198745) Quick inquiry Where to buy Suppliers range | Used in the treatment of benign prostatic hyperlasia. It inhibits both isozymes of 5a-reductase. Group: Biochemicals. Alternative Names: GG-745, GI-198745. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
FR 236924 Quick inquiry Where to buy Suppliers range | FR 236924 is a selective PKCε activator with > 7-fold selectivity over other PKC isozymes. FR 236924 promotes glutamate release via presynaptic α7 nicotinic receptors on glutamatergic terminals in vitro and enhances cognition in vivo. It has the potential for the treatment of Alzheimer disease. Synonyms: FR 236924; FR236924; FR-236924; Dcp-LA; 2-[ (2-Pentylcyclopropyl) methyl]cyclopropaneoctanoic acid. Grades: ≥99% by HPLC. CAS No. 28399-31-7. Molecular formula: C20H36O2. Mole weight: 308.5. | |
Furosemide Impurity F Quick inquiry Where to buy Suppliers range | Furosemide Impurity F is used as a carbonic anhydrase inhibitor inhibiting human, bacterial and archaeal isozymes. Synonyms: Tetrahydro Furosemide; 4-Chloro-5-sulfamoyl-N-(tetrahydrofurfuryl)anthranilic Acid; 4-Chloro-5-Sulfamoyl-2-[[((2RS)-Tetrahydrofuran-2-yl)methyl]amino]Benzoic Acid. Grades: > 95%. CAS No. 4793-38-8. Molecular formula: C12H15ClN2O5S. Mole weight: 334.78. | |
GF-109203X Quick inquiry Where to buy Suppliers range | GF-109203X is a potent and highly selective PCK inhibitor, which inhibits PKC isozymes alpha, beta 1, beta 2, gamma, delta and epsilon in vitro. GF-109203X inhibited GSK-3 in vitro, when assayed either in cell lysates (IC(50) 360 nM or in GSK-3beta immunoprecipitates (IC(50) 170 nM derived from rat epididymal adipocytes. Pretreatment of adipocytes with GF-109203X (5 microM) reduced GSK-3 activity in total cell lysates, to 25.1+/-4.3% of control. Synonyms: GF109203X; GF 109203X; Bisindolylmaleimide i; GO 6850; GO-6850; GO6850; 2-[1-(3-dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide. Grades: ≥98%. CAS No. 133052-90-1. Molecular formula: C25H24N4O2. Mole weight: 412.49. | |
HDAC Inhibitor XXIII, Tubastatin A (N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide, HCl) Quick inquiry Where to buy Suppliers range | A cell-permeable carbazolohydroxamate compound that acts as a highly potent, reversible and active-site zinc-binding HDAC6 inhibitor with excellent selectivity among other HDAC isozymes (IC50=0.015, 0.854, 16.4uM for HDAC6, HDAC8 and HDAC1, respectively) with no activity towards HDAC2, 3, 4, 7, 9, 10 and 11 (IC50>30uM). Shown to induce a-tubulin hyperacetylation at 2.5uM, and offer complete neuroprotection in primary cortical rat neuronal cells against homocysteic acid (HCA)-induced oxidative stress at 10uM with no noticeable neurotoxicity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
HIF-PHD Inhibitor II, JNJ-42041935 (HIF Prolyl Hydroxylase Inhibitor II, 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid) Quick inquiry Where to buy Suppliers range | A cell-permeable benzimidazolopyrazole compound that acts as an active-site binding, iron insensitive, 2-oxoglutarate competitive, reversible and potent inhibitor of PHD1, 2 and 3 isozymes (pKi=7.91, 7.29 and 7.65, respectively). Displays >100-fold selectivity over FIH (factor inhibiting hydroxylase; pIC50 ~4) and minimal affinity towards a panel of receptors, enzymes and kinases. Shown to elevate HIF-1a levels in Hep3B cells and stimulate erythropoietin secretion in mice, and reverse inflammation-induced anemia in rats (100uM/kg). Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?ClF?N?O?, Molecular Weight: 346.7. US Biological Life Sciences. | Worldwide |
Irsogladine Maleate Quick inquiry Where to buy Suppliers range | Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. It inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice. It up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy. It also produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions. Synonyms: Dicloguamine maleate; MN1695; MN 1695; MN-1695. Grades: >98%. CAS No. 84504-69-8. Molecular formula: C13H11Cl2N5O4. Mole weight: 372.16. | |
Ketohexokinase Inhibitor (N8-(Cyclopropylmethyl)-N4-(2-(methylthio)phenyl)-2-(1-piperazinyl)-pyrimido[5,4-d]pyrimidine-4,8-diamine, KHK Inhibitor) Quick inquiry Where to buy Suppliers range | An orally bioavailable pyrimidinopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of human hepatic KHK activity (KHK-C isoform; IC50=12nM in a transcreener ADP assay) and efficiently blocks fructose-1-phosphate secretion (IC50 ≤ 400nM in HepG2 cells). Displays ~50-fold lower potency towards metabolic kinases, namely, ribokinase, hexokinase and adenosine kinase, and minimal binding affinities to diverse receptors and ion-channels, and excellent selectivity among a panel of 31-kinases including Akt1, AMPK, CaMKI/II, InsR, IRAK4, PKA and PKCtheta (IC50 >> 10uM). Shown to minimally affect the activities of human cytochrome p450 isozymes (1A2, 2C19, 2D6, 2C9 and 3A4), and exhibit high volume of distribution and high rate of clearance in rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?S 2HCl. US Biological Life Sciences. | Worldwide |
LY-333,531 hydrochloride Quick inquiry Where to buy Suppliers range | Isozyme selective inhibitor of protein kinase Cbeta (PKCbeta). PKCbetaI and PKCbetaII isozyme inhibitor. Amelioriates diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy. Anti-cancer and anti-angiogenic compound. Suppresses glucose-induced adhesion of human monocytes to endothelial cells. Suppresses ERK1/2 and Akt phosphorylation. Group: Biochemicals. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C28H28N4O3 HCl. US Biological Life Sciences. | Worldwide |
LY-333,531 hydrochloride (Ruboxistaurin) Quick inquiry Where to buy Suppliers range | An isozyme-selective inhibitor of protein kinase Cb (PKCb). Inhibits both the PKCbI (IC??=4.7 nM) and PKCbII (IC??=5.9nm) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of PKCbI and PKCbII over PKCa. Group: Biochemicals. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
MK-2 Inhibitor IV, MK-25 (MAPKAP-K2 Inhibitor IV, MK-25, 5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide, HCl) Quick inquiry Where to buy Suppliers range | A cell-permeable furanylcarboxamide compound that acts as a potent, reversible and non-ATP-competitive inhibitor of MK-2/MAPKAP-K2 activity (IC50=110nM; EC50=350nM for pHSP27 in IL-1b-stimulated SW1353 cells) with excellent selectivity over 150 kinases (% activity inhibition at 10uM against human CK2, Haspin, Arg and CK1y3=40, 40, 42 and >70, respectively). Shown to efficiently suppress the secretions of TNFa, IL6 (IC50=4.4 and 5.2uM in LPS-stimulated THP1 cell, respectively) and MMP-13 (IC50=5.7 and 2.2uM in IL1b-stimulated SW1353 and in primary osteoarthritis-derived chondrocytes, respectively). Exhibits desirable bioavailability and weakly inhibits a panel of cytochrome P450 isozymes (IC50>20uM for 3A4, 2D6 and 2C9). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
MS-PPOH Quick inquiry Where to buy Suppliers range | MS-PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes. It potently inhibits two CYP450 epoxygenases CYP2C9 and CYP2C11 (IC50 = 11-16 μM). Synonyms: N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide. Grades: ≥98%. CAS No. 206052-02-0. Molecular formula: C16H21NO4S. Mole weight: 323.4. | |
p38 MAP Kinase Inhibitor XI (4-(2,4-Difluorophenyl)-8-(2-methylphenyl)-1,7-naphthyridine-7-oxide, 4-(2,4-Difluorophenyl)-8-o-tolyl-1,7-naphthyridine-7-oxide) Quick inquiry Where to buy Suppliers range | A cell-permeable naphthyridine N-oxide compound that acts as a potent, reversible p38alpha MAP kinase inhibitor (IC50 = 68nM) and exhibits excellent selectivity among 54-kinases. It acts on the ATP-binding site plus an adjacent hydrophobic pocket. Exhibits desirable ADME (Absorption, Distribution, Metabolism, and Excretion) profile with good microsomal stability, low toxicity, and low reactivity towards cytochrome P450 isozymes. Shown to inhibit lipopolysaccharide-induced TNF-alpha production in a dose-dependent manner (ED50 of 0.5mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Panobinostat (LBH-589, LBH589, LBN-589, NVP-LBH589) Quick inquiry Where to buy Suppliers range | Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumor cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12nm, respectively. And to A2780 proliferation, IC50 value is 4.6±1.8nm. Group: Biochemicals. Grades: Highly Purified. CAS No. 404950-80-7. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
PET-cGMP Quick inquiry Where to buy Suppliers range | PET-cGMP is a potent stimulator of isozymes I α and I ß of cGMP-dependent protein kinase. Synonyms: ?- Phenyl- 1, N2-ethenoguanosine- 3', 5'-cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 78080-27-0. Molecular formula: C18H15N5O7P · Na. Mole weight: 467.3. | |
PFKFB3 Inhibitor, 3PO (6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitor, 3PO, 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one, (2E)-3-Pyridin-3-yl-1-pyridin-4-ylprop-2-en-1-one) Quick inquiry Where to buy Suppliers range | A cell-permeable dipyridinyl-propenone compound that selectively blocks PFK-2 (6-phosphofructo-2-kinase) activity of PFKFB3 isozyme over PFK-1 (6-phosphofructo-1-kinase) in a mixed-mode manner. Rapidly decreases fructose-2,6-bisphosphate (F-2,6-P2) and 2-deoxyglucose uptake, and lactate secretion; efficiently arrests proliferation of transformed cells (IC50 ~1.4uM in NHBE-ht/LT/ras) and suppresses tumor growth in several xenograft mouse models (70mg/kg, i.p.). The cytostatic and cytotoxic effects of 3PO is shown to be highly sensitive to the intracellular levels of F-6-P (fructose-6-phosphate) and F-2,6-P2. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
PIP3 Antagonist, PITenin-7 Quick inquiry Where to buy Suppliers range | A cell-permeable benzoylthiourea compound that acts as a PIP3 (phosphatidylinositol-3, 4, 5-triphosphate) mimic and inhibits PI 3-K/PIP3/Akt signaling. Shown to efficiently disrupt PIP3/Akt1 PH (pleckstrin-homology) domain interaction over PIP3/PDK1 PH (IC50=13.4 and 52.3uM) in a reversible manner, and remain inactive toward PIP3/Btk, PIP3/ARNO, PIP3/GRP1 and PIP2/PLC-d/TAPP1/TAPP2 PH domains. Blocks phosphorylation of Akt-Ser473 and -Thr308 and its downstream targets, GSK-3B-Ser9 and S6-Ser235/236 and induces metabolic stress and cell death (IC50=6.6uM) in PTEN-deficient U87MG cells. Further, synergizes with Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 and Akt Inhibitor X. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PPOH Quick inquiry Where to buy Suppliers range | PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes. Synonyms: 6-(2-propargyloxyphenyl)hexanoic acid. Grades: ≥99%. CAS No. 206052-01-9. Molecular formula: C15H18O3. Mole weight: 246.3. | |
rac erythro-9-(2-Hydroxy-3-nonyl)adenine, Hydrochloride (EHNA) Quick inquiry Where to buy Suppliers range | A potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does ot inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM). Group: Biochemicals. Alternative Names: EHNA. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Reboxetine Quick inquiry Where to buy Suppliers range | Reboxetine, also called as Vestra, 2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate, exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine. Ti is a selective norepinephrine reuptake inhibitor used in the treatment of clinical depression, panic disorder and ADD/ADHD which has been approved for treatment of major depression. In vitro: it inhibits noradrenaline reuptake in vitro to a similar extent to the tricyclic antidepressant desmethylimipramine and does not inhibit the activity of the following isozymes of cytochrome P450: CYP1A2, CYP2C9, CYP2C19, and CYP2E1; In vivo: Reboxetine does not affect dopamine or serotonin reuptake and it has low in vivo and in vitro affinity for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors.Besides, it inhibits both CYP2D6 and CYP3A4 with low binding affinities, but has shown no effect on the in vivo clearance of drugs metabolized by these enzymes. Inhibits (±)-epibatidine-induced Ca(2+) influx in human (h) muscle embryonic (hα1β1γδ) and adult (hα1β1εδ) AChRs in a non-competitive manner , with potencies IC50= 3.86±0.49 and 1.92±0.48 μM, respectively. Uses: A selective norepinephrine reuptake inhibitor used in the treatment of clinical depression, panic disorder and add/adhd, it has been approved for treatment of major depression. Synonyms: Norebox; 2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate; Morpholine, 2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-, (2R)-rel-; (R,R)-Reboxetine. Grades: ≥ 95.0%. CAS No. 98769-81-4. Molecular formula: C19H23NO3. Mole weight: 313.39. | |
SB 216763 (SB216763, SB-216763, SCHEMBL30251) Quick inquiry Where to buy Suppliers range | SB 216763 is a potent and selective ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK-3), including the alpha and beta isozymes. It displays neuroprotectant properties and stimulates glycogen synthesis in liver cells. SB 216763 is reported to be used to maintain the undifferentiated state of mouse embryonic stem cells. Group: Biochemicals. Alternative Names: 3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione. Grades: Highly Purified. CAS No. 280744-09-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
Sotrastaurin Quick inquiry Where to buy Suppliers range | Sotrastaurin, also known as AEB-701, is an orally available pan-protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities. Sotrastaurin inhibits both T- and B-cell activations via PKC theta and beta isozymes, respectively. Both PKCs are important in the activation of nuclear factor-kappaB (NF-kB). Inhibition of PKC beta in B-cells results in prevention of NF-kB-mediated signaling and down regulation of NF-kB target genes. This may eventually lead to an induction of G1 cell cycle arrest and tumor cell apoptosis in susceptible tumor cells. This agent may act synergistically with other chemotherapeutic agents. PKC, a family of serine/threonine protein kinases overexpressed in certain types of cancer cells, is involved in cell differentiation, mitogenesis, inflammation, and the activation and survival of lymphocytes. Synonyms: AEB-071; AEB071; AEB 071. Grades: >98%. CAS No. 425637-18-9. Molecular formula: C25H22N6O2. Mole weight: 438.491. | |
Sp-5,6-DCl-cBIMPS Quick inquiry Where to buy Suppliers range | Sp-5,6-DCl-cBIMPS is a selective stimulator of cAMP- dependent protein kinases preferrring site B of type II isozyme. It is superior to dibutyryl cAMP or 8-CPT-cAMP in stability, membrane permeability and potency. Synonyms: 5, 6- Dichlorobenzimidazole riboside- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 120912-54-1. Molecular formula: C12H10Cl2N2O5PS · Na. Mole weight: 419.2. | |
Suc-Leu-Leu-Val-Tyr-AMC Quick inquiry Where to buy Suppliers range | Suc-Leu-Leu-Val-Tyr-AMC is a fluorogenic substrate of calpains and 20S proteasome and used to study the activity of calpains and proteosomal degradation. It is also a substrate for carboxypeptidase Y, proteinase yscE (kexin), ingensin, as well as for porcine calpain isozymes I and II and for papain. Uses: Peptide Inhibitors. CAS No. 94367-21-2. Product ID: R0808. | |
Terpendole C Quick inquiry Where to buy Suppliers range | Inhibitor for Acyl-CoA, cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2, Tremorgenic and Cholesteryl ester (CE) synthesis. Group: Biochemicals. Grades: Highly Purified. CAS No. 156967-65-6. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
Terpendole C Quick inquiry Where to buy Suppliers range | Isolated from Albophoma yamanashiensis. An acyl-CoA:cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2 inhibitor. Also acts as a tremorgen and cholesteryl ester (CE) synthesis inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 156967-65-6. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
Trk Inhibitor III, GNF-5837 ( (Z) -1- (3- ( (3- ( (1H-Pyrrol-2-yl) methylene) -2-oxoindolin-6-yl) amino) -4-methylphenyl) -3- (2-fluoro-5- (trifluoromethyl) phenyl) urea) Quick inquiry Where to buy Suppliers range | An orally bioavailable oxindole compound that and acts as a potent, reversible and type II DFG-out inhibitor of pan-Trk activity (IC50=8 and 12nM for TrkA and TrkB). Shown to target Trk (tropomyosin receptor kinase) ATP binding cleft and an immediately adjacent hydrophobic pocket. Preferentially arrests the proliferation of Ba/F3 cells fused with Tel-TrkA, Tel-TrkB and Tel-TrkC (IC50=11, 9 and 7nM, respectively) and in Ba/F3 and RIE cells expressing both TrkA and NGF (IC50=42 and 17nM, respectively) over Mo7e-c-Kit and Rat-A10-PDGFR (IC50=1 and 0.5uM) and Ba/F3-Tel-R and wt-Ba/F3 cells (IC50=3.0 and 5.6uM). Displays ~100-fold greater selectivity among a panel of 59 closely related kinases and in 33 cellular kinase assays. Weakly active against relevant cytochrome P450 isozymes and hERG channel, and exhibit adequate microsomal stability, pharmacokinetic profile and efficacy in mice and rats. Suppresses tumor growth in a mouse RIE-TrkAmNGF xenograft model (50mg/kg, p.o.). Group: Biochemicals. Grades: Highly Purified. CAS No. 1033769-28-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Tubastatin A Quick inquiry Where to buy Suppliers range | Tubastatin A is selective at all isozymes except HDAC8 and maintains over 1000-fold selectivity against all isoforms excluding HDAC8, where it has approximately 57-fold selectivity. Grades: >98%. CAS No. 1252003-15-8. Molecular formula: C20H21N3O2. Mole weight: 335.4. | |
Tubastatin A HCl salt Quick inquiry Where to buy Suppliers range | Tubastatin A is a potent and selective HDAC6 inhibitor. Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM. Grades: 0.98. CAS No. 1310693-92-5. Molecular formula: C20H22ClN3O2. Mole weight: 371.865. | |
Vibralactone D Quick inquiry Where to buy Suppliers range | Vibralactone D is isolated from Boreostereum vibrans and exhibits weak inhibitory effect against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD). Synonyms: (1S,5R,6S)-6-hydroxy-5-(3-methylbut-2-enyl)-3-oxabicyclo[3.2.1]octan-4-one; 3-Oxabicyclo[3.2.1]octan-2-one, 7-hydroxy-1-(3-methyl-2-buten-1-yl)-, (1R,5S,7S)-. Grades: ≥98%. CAS No. 1251748-32-9. Molecular formula: C12H18O3. Mole weight: 210.27. | |
ZIP Quick inquiry Where to buy Suppliers range | ZIP is a cell-permeable inhibitor of protein kinase Mζ (PKMζ), which is a constitutively active and atypical PKC isozyme involved in LTP maintenance. ZIP selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. ZIP reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Synonyms: ZIP; FLJ36473; DAPK3, active, GST tagged human; PKC Zeta Pseudosubstrate Inhibitory peptide; Protein kinase Cζ pseudosubstrate, myristoyl trifluoroacetate salt; N-(1-Oxotetradecyl)-L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginylglycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl-L-leucine. CAS No. 863987-12-6. Molecular formula: C90H154N30O17. Mole weight: 1928.37. | |
ZIP Quick inquiry Where to buy Suppliers range | Protein kinase Mξ (PKMξ), as an active form of protein kinase C (PKC) isozyme, is necessary and potent for long-term potentiation (LTP) maintenance. ZIP is a novel and cell-permeable inhibitor for PKMξ and therefore it can block LTP. Uses: Peptide Inhibitors. CAS No. 863987-12-6. Product ID: R0804. | |
ZIP acetate Quick inquiry Where to buy Suppliers range | ZIP acetate is a cell-permeable inhibitor of protein kinase Mζ (PKMζ), which is a constitutively active and atypical PKC isozyme involved in LTP maintenance. ZIP selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. ZIP reverses late-phase LTP (IC50 = 1-2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Synonyms: myristoyl-Arg-Leu-Tyr-Arg-Lys-Arg-Ile-Trp-Arg-Ser-Ala-Gly-Arg-OH.CH3CO2H; N-myristoyl-L-arginyl-L-leucyl-L-tyrosyl-L-arginyl-L-lysyl-L-arginyl-L-isoleucyl-L-tryptophyl-L-arginyl-L-seryl-L-alanyl-glycyl-L-arginine acetic acid; N-(1-Oxotetradecyl)-L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginylglycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl-L-leucine acetate; Peptide ZIP acetate; z-Pseudosubstrate inhibitory peptide acetate. Grades: ≥94%. Molecular formula: C92H158N30O19. Mole weight: 1988.43. |