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| Product | Description | |
|---|---|---|
| Keratin | Keratin is a fibrous protein that comprises the majority of the structure of hair, nails, and the outer layer of the skin in mammals. It is a very strong and durable protein that provides essential mechanical strength and protective functions to these structures. In hair, keratin helps to give it its strength, flexibility, and elasticity. In nails, it provides the hardness and durability needed to protect them from damage. In the skin, it helps to form a barrier against harmful substances and pathogens. Keratin is produced by special cells called keratinocytes, which are found in the outer layer of the skin and in the hair follicles. Uses: 1. hair care products: keratin is widely used in hair care products like shampoos, conditioners, and hair serums. it helps in repairing damaged hair by strengthening hair fibers, smoothing the hair cuticle, and adding shine to dull hair. 2. skin care products: keratin is also used in skin care products like moisturizers, creams, and lotions. it helps in improving skin elasticity by promoting colla. Group: Hair actives. CAS No. 68238-35-7. Appearance: Keratin is a fibrous protein that appears as long, slender, and cylindrical strands. Catalog: CI-HC-0228. |  |
| Keratinase | Keratinase (KerA) is a protease that are able to degrade keratins into amino acids [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KerA. CAS No. 37341-53-0. Pack Sizes: 500 U. Product ID: HY-E70193. |  |
| Keratinase, Recombinant | Keratinase is a particular class of extracellular proteolytic inducible enzyme with the capability of degrading insoluble keratin substrates. It is important for hydrolyzing hair, feather, and collagen in sewage system during waste water treatment. It is also useful in food industry, animal feed preparation etc. Insoluble feather keratin from poultry industry may be converted by enzymatic hydrolysis to glues, feedstuffs, fertilizers, films or used for the production of rare amino acids serine, cysteine and proline. Applications: Keratinase was used for enzymatic treatment of elementary body (eb), gag molecules, and cells in the study of the role glycosaminoglycans (gags) in the invasion of host cells by chlamydia pneumoniae strains. Group: Enzymes. Synonyms: Keratinase; KerA; Keratinase from Bacillus licheniformis; Keratinolytic protease; EC 3.4.21. Enzyme Commission Number: EC 3.4.21. Keratinase. Mole weight: ~39 kDa. Activity: 300 - 1000 units/mg. Storage: Store at -20°C. Form: Lyophilized powder. Source: E. coli BL21. Keratinase; KerA; Keratinase from Bacillus licheniformis; Keratinolytic protease; EC 3.4.21. Cat No: NATE-0853. |  |
| Keratin, Hydrolyzed | Protein serving structural and protective functions, present in hair and skin. Group: Biochemicals. Grades: Highly Purified. CAS No. 69430-36-0. Pack Sizes: 10g, 25g, 50g, 100g, 250g. US Biological Life Sciences. |  Worldwide |
| Keratinocyte Transfection Kit | Transfection Reagent for Keratinocyte Cells. Optimized transfection protocol provided for transfection of siRNA, DNA, mRNA, and microRNA. Transfection Reagents. Transfection Enhancer. Complex Condenser. Uses: Transfection of DNA, RNA, protein and small molecules. Product ID: 1784. |  Nevada, Texas, USA |
| Keratin Protein, Hydrolyzed | Sheep-wool derived, hydrolyzed alpha-keratin protein carefully monitored during its manufacture to ensure the lowest possible odor and a low ash. Keratin is a highly specialized fibrous protein, which is found in hair, feathers, wool and nails. Keratin is distinct from other proteins in that it is rich in cysteine (a sulfur-containing amino acid) giving keratin a unique strength and protective quality. Derived from sheep's wool. Contains 20-23% of protein. Molecular weight: 1,100-3,300 Da. Gluten-free. Uses: All kinds of hair care products including shampoos, hair conditioners, hair balms, hair pomades and also skin care products including lotions and creams. Group: Cationic surfactants & conditioning agents. CAS No. 69430-36-0. Appearance: Clear amber liquid, characteristic odor. Catalog: CI-HC-0063. | |
| Hydrolyzed Keratin Peptide Powder (Food Grade) | Hydrolyzed Keratin Peptide Powder (Food Grade). Categories: l-citrulline; citrulline. |  CA, FL & NJ |
| Native Bacillus licheniformis Keratinase (feed grade) | Keratinase is a particular class of extracellular proteolytic inducible enzyme with the capability of degrading insoluble keratin substrates. It is important for hydrolyzing hair, feather, and collagen in sewage system during waste water treatment. It is also useful in food industry, animal feed preparation etc. Insoluble feather keratin from poultry industry may be converted by enzymatic hydrolysis to glues, feedstuffs, fertilizers, films or used for the production of rare amino acids serine, cysteine and proline. Group: Enzymes. Synonyms: KerA; Keratinolytic protease; EC 3.4.21. Enzyme Commission Number: EC 3.4.21. Keratinase. Form: Powder. Source: Bacillus licheniformis. Keratinase; KerA; Keratinase from Bacillus licheniformis; Keratinolytic protease; EC 3.4.21. Cat No: FEED-0001. | |
| Transglutaminase 1 from Human keratinocyte, Recombinant | Transglutaminase is based on the TGM1-allele from I.M.A.G.E.-clone IRAKp961M1628 isolated from human skin squamous cell carcinoma. It is N-terminally fused to a hexahistidine-tag resulting in the encoded N-terminal amino acid sequence MHHHHHHMDGPR. Transglutaminase is purified by IMAC to more than 90 % purity. Applications: This product catalyzes acyl transfer reactions from glutamin residues in proteins or peptides to primary amines, e. g. the formation of ε-(γ-glutamyl) lysine bonds between proteins by transferring the acyl group of a peptide-bound glutamine residue to the primary amino group of a peptide-bound lysine residue. this enzyme may also ...odansylcadaverine-incorporation into N,N-dimethylated casein according to Lorand et al., Anal. Biochem. 44 (221-231)]. Appearance: White lyophilized solid. Storage: Store at ≤ - 20°C. Store working aliquots at ≤ - 20°C. Avoid repeated freezing and thawing.Delivery at ambient temperature is possible. Form: The transglutaminase is lyophilized from 50 mM Tris-HCl pH 8.0, 10 mM Glutathion. Source: E. coli. Species: Human. transglutaminase; EC 2.3.2.13; 80146-85-6; transglutaminase; Factor XIIIa; fibrinoligase; fibrin stabilizing factor; glutaminylpeptide γ-glutamyltransferase; polyamine transglutaminase; tissue transglutaminase; R-glutaminyl-peptide:amine & | |
| 1- (Trimethoxysilyl) methanamine | An organosilane found in a compound composition used for lightening and/or dyeing of keratin fibers. Group: Biochemicals. Alternative Names: (Aminomethyl) trimethoxysilane; SLM 88705. Grades: Highly Purified. CAS No. 71408-48-5. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C4H13NO3Si. US Biological Life Sciences. | Worldwide |
| 25-Hydroxytachysterol3 | 25-Hydroxytachysterol3 is the metabolite of Vitamin D3 (HY-15398). 25-Hydroxytachysterol3 inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts, stimulates the expression of differentiation- and antioxidant-related genes in keratinocytes. 25-Hydroxytachysterol3 activates vitamin D receptor ( VDR ) and aryl hydrocarbon receptor ( AhR ), liver X receptor α/β ( LXR α/β ) and peroxisome proliferator-activated receptor γ ( PPARγ ), stimulates the expression of CYP24A1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 39932-44-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-77278. | |
| Adapalene Elastic Liposome | Adapalene (ADA) is a synthetic retinoid that belongs to the class of topical anti-acne drugs. It regulates the differentiation of keratinocyte cells, promotes keratin dissolution, and has anti-inflammatory and anti-seborrheic effects. However, it can cause irritation and photosensitivity. This product is a pre-formulated liposome encapsulating Adapalene. This product uses Tween-80 to increase elasticity, facilitating easier drug penetration through the skin. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes. |  |
| Adapalene Flexible Liposome | Adapalene (ADA) is a synthetic retinoid that belongs to the class of topical anti-acne drugs. It regulates the differentiation of keratinocyte cells, promotes keratin dissolution, and has anti-inflammatory and anti-seborrheic effects. However, it can cause irritation and photosensitivity. This product is a pre-formulated liposome encapsulating Adapalene. This product is formulated with propylene glycol to enhance its deformability, making the drug more permeable through the skin. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes. | |
| Adapalene Liposome | Adapalene (ADA) is a synthetic retinoid that belongs to the class of topical anti-acne drugs. It regulates the differentiation of keratinocyte cells, promotes keratin dissolution, and has anti-inflammatory and anti-seborrheic effects. However, it can cause irritation and photosensitivity. This product is a pre-formulated liposome encapsulating Adapalene. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes. | |
| Adapalene Thermosensitive Liposome | Adapalene (ADA) is a synthetic retinoid that belongs to the class of topical anti-acne drugs. It regulates the differentiation of keratinocyte cells, promotes keratin dissolution, and has anti-inflammatory and anti-seborrheic effects. However, it can cause irritation and photosensitivity. This product is a pre-formulated liposome encapsulating Adapalene. This product incorporates DPPC, which releases the drug at temperatures ranging from 39 to 42°C. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes. | |
| Amarogentin | Amarogentin exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways and displays immunomodulatory effects in human mast cells and keratinocytes. It inhibits the growth of SNU-16 human gastric cancer cells (IC50 = 12.4 μM) and increases apoptosis when used at a concentration of 50 μM. Amarogentin dose-dependently reduces tumor growth in a SNU-16 nude mouse xenograft model. Amarogentin may offer therapeutic potential for preventing or treating thromboembolic disorders, it prevents platelet activation through the inhibition of PLC γ2-PKC cascade and MAPK pathway. Synonyms: Amarogentin; 21018-84-8; 5L82GT5I0W; [(2S,3R,4S,5S,6R)-2-[[(3S,4R,4aS)-4-ethenyl-8-oxo-4,4a,5,6-tetrahydro-3H-pyrano[3,4-c]pyran-3-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl] 2,4-dihydroxy-6-(3-hydroxyphenyl)benzoate; sweroside-2'-(3'',5'',3'''-trihydroxydiphenyl)-2''-carboxylic acid ester; (4aR)-5t-ethenyl-6c-[O(2)-(3,5,3'-trihydroxybiphenyl-2-ylcarbonyl)-beta-D-glucopyranosyloxy]-4,4ar,5,6-tetrahydro-3H-pyrano[3,4-c]pyran-1-one; (4aS,5R,6S)-5-ethenyl-1-oxo-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-6-yl- 2-O-[(3,3',5-trihydroxybiphenyl-2-yl)carbonyl]-beta-D-glucopyranoside. Grades: ≥98%. CAS No. 21018-84-8. Molecular formula: C29H30O13. Mole weight: 586.54. |  |
| Betamethasone hydrochloride | Betamethasone hydrochloride is the hydrochloride of betamethasone, which is a synthetic corticosteroid and agonist of glucocorticoid receptor. It does not cause water retention. It has shown the inflammatory response by the betamethasone-receptor complex modulated the activity of certain genes, altering the production and activity of proteins. It has also revealed to inhibit keratinocyte proliferation. It has anti-inflammatory and immunosuppressive properties. Uses: Betamethasone hydrochloride inhibits keratinocyte proliferation. it has anti-inflammatory and immunosuppressive properties. Grades: >98 %. CAS No. 956901-32-9. Molecular formula: C22H30ClFO5. Mole weight: 428.92. | |
| Bisindolylmaleimide VIII acetate | Selective protein kinase C (PKC) inhibitor. Inhibits proliferation of cultured mouse epidermal keratinocytes. Enhances Fas- and TRAIL-mediated apoptosis. Inhibits T cell-mediated autoimmune diseases. Inhibits stimulation of insulin secretion by glucose. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Group: Biochemicals. Alternative Names: Ro 31-7549, BIM VIII. Grades: Highly Purified. CAS No. 138516-31-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H22N4O2. CH3COOH. US Biological Life Sciences. | Worldwide |
| BMS480404 | BMS480404 is a potent small molecule inhibitor. It bounds to human keratinocyte fatty acid-binding protein. Synonyms: BMS-480404; BMS 480404; (S)-2-(2,3-bis(2-chlorobenzyloxy)phenyl)-2-hydroxyacetic acid. Grades: 98%. CAS No. 533889-36-0. Molecular formula: C22H18Cl2O5. Mole weight: 433.28. | |
| Calcipotriol (Calcipotriene) Monohydrate | Calcipotriol increased hCAP18 mRNA expression in IL-17/IL-22-stimulated keratinocytes. However, LL37 peptide in the culture supernatants was reduced by calcipotriol. Calcipotriol and FTY720 augment IL-2-activated NK cell lysis of K562 and RAJI tumor cell lines as well as immature (I) and mature (m) DCs, with variable efficacies.vitamin D3, calcipotriol and FTY720 enhance NK17/NK1 cell lysis of K562 cells, suggesting that a possible mechanism of action for these drugs is via activating these newly described cells. MC 903 (calcipotriol) is a novel vitamin D3 analogue which is at least 100 times less potent than 1,25-(OH)-2-D3 in its effects on calcium homeostasis. A total of 160 SKH-1 mice were randomized to one placebo group and four chemoprevention groups (diclofenac plus difluoromethylornithine; diclofenac plus calcipotriol; difluoromethylornithine plus calcitriol; and diclofenac plus difluoromethylornithine plus calcipotriol). Synonyms: Calcipotriol monohydrate. Grades: >98%. CAS No. 147657-22-5. Molecular formula: C27H42O4. Mole weight: 430.62. | |
| Cholesteryl sulfate sodium | Cholesteryl sulfate sodium is an orally available, NPC2 -targeted cholesterol biosynthesis agonist. Cholesteryl sulfate sodium activates SREBP2 by competitively binding to NPC2, promoting cholesterol synthesis ( EC 50 =50 μM). Cholesteryl sulfate sodium enhances the self-assembly ability of Mitoxantrone hydrochloride (HY-13502A), while repairing the intestinal mucosal barrier and inhibiting inflammation by regulating serine protease activity and PKCη signaling pathway. Cholesteryl sulfate sodium is a component of the platelet cell membrane and supports platelet adhesion. Cholesteryl sulfate sodium also regulates the activity of selective protein kinase C isoforms and modulates the specificity of PI3K, playing a role in keratinocyte differentiation [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 2864-50-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111355B. | |
| Dermcidin-1L (human) | The protein dermcidin expressed in sweat glands is secreted into the sweat and transported to the epidermal surface. The concomitant processing of the protein yields a broad-spectrum antimicrobial 47 amino acid peptide, dermcidin-1 (DCD-1). Dermcidin and naturally occurring DCD-1L fragments do not interfere with membrane permeability and bind to different surface molecules. DCD-1L stimulates keratinocytes to produce cytokines and chemokines such as TNF-α, IL-8, CXCL10 and CCL20. Synonyms: DCD-1L (human); H-Ser-Ser-Leu-Leu-Glu-Lys-Gly-Leu-Asp-Gly-Ala-Lys-Lys-Ala-Val-Gly-Gly-Leu-Gly-Lys-Leu-Gly-Lys-Asp-Ala-Val-Glu-Asp-Leu-Glu-Ser-Val-Gly-Lys-Gly-Ala-Val-His-Asp-Val-Lys-Asp-Val-Leu-Asp-Ser-Val-Leu-OH. Grades: ≥95%. CAS No. 478898-18-9. Molecular formula: C210H359N57O71. Mole weight: 4818.50. | |
| D-Galactose-6-O-sulphate sodium salt | It is an ingredient in some types of carrageenan and is also present in keratin sulfate. Synonyms: Gal-6S sodium salt; D-Galactose 6-(Hydrogen Sulfate) Sodium Salt (1:1); D-galactose-6-sulfate sodium; Sodium 6-O-sulfonato-D-galactopyranose; D-Galactopyranose 6-(sulfuric acid sodium) salt; sodium ((2R,3R,4S,5R)-3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-yl)methyl sulfate. Grades: ≥95%. CAS No. 125455-62-1. Molecular formula: C6H11O9SNa. Mole weight: 282.20. | |
| D-Glucosamine-6-O-sulphate | It is a component of heparin, heparin sulfate, keratin sulfate, and cell surface glycoconjugates. Synonyms: D-Glucosamine 6-Sulfate; GLCN-6S; {[(2R,3S,4R,5R)-5-amino-2,3,4-trihydroxy-6-oxohexyl]oxy}sulfonic acid; 2-Amino-2-deoxy-6-O-sulfo-D-glucose; D-Glucose, 2-amino-2-deoxy-, 6-(hydrogen sulfate). Grades: ≥95%. CAS No. 91674-26-9. Molecular formula: C6H13NO8S. Mole weight: 259.23. | |
| Diethyl Phosphate-13C4 Sodium Salt | Labeled Diethyl Phosphate. Used in a cosmetic composition for treating keratin materials. Group: Biochemicals. Alternative Names: Phosphoric Acid Diethyl Ester-13C4 Sodium Salt; Ethyl Sodium Phosphate-13C4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Efalizumab | Efalizumab is a targeted T cell modulator, and is a humanized monoclonal antibody of CD11a , the α subunit of LFA-1. Efalizumab inhibits T cell activation, cutaneous T cell trafficking, and T cell adhesion to keratinocytes, can be used for plaque psoriasis research [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 214745-43-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9947. | |
| Eye Lash Hexa Peptide | Eye lash peptide that has been shown to stimulate keratin genes in in-vitro studies. Content 1000ppm of myristoyl hexapeptide-16. Can be combined with Myristoyl Pentapeptide-17. Uses: Eye lash serums, apply to the root of the eyelash, once daily at night. Group: Skin actives. CAS No. 7732-18-5/56-81-5/959610-54-9. Appearance: Colorless to pale beige, clear liquid, faint odor. Catalog: CI-SC-0946. | |
| Eye Lash Penta Peptide | Eye lash peptide that has been shown to stimulate keratin genes in in-vitro studies. Content 1000ppm of myristoyl pentapeptide-17. Can be combined with Myristoyl Hexapeptide-16. Uses: Recommended to be combined with eye lash hexa peptide for best results visible effect in 2-4 weeks. best results at 6 weeks. hair on the eyelashes and eyebrows have a very short active growth phase of only about 30-45 days which explains why they are shorter than scalp hair. approximately 60-80% of the eyelashes are in this phase. entire duration of cycle for the eyelashes is 3-4 months where as the scalp hair cycle is about 3-6 years. Group: Skin actives. CAS No. 7732-18-5/56-81-5/959610-30-1. Appearance: Amber, clear liquid, faint odor. Catalog: CI-SC-0945. | |
| Fmoc-L-tyrosine | N-Fmoc-L-tyrosine is an N-Fmoc-protected form of L-Tyrosine. L-Tyrosine is an essential amino acid that exhibits in vitro antioxidant and antiradical activities. L-Tyrosine is used as a precursor to synthesize catecholamines in human keratinocytes, and also for the synthesis of proteins and thyroid hormones. Synonyms: Fmoc-L-Tyr-OH; Fmoc-L-Tyrsine; FMOC-TYROSINE; 9-fluorenylmethyloxycarbonyl tyrosine; FMOC-TYR-OH. Grades: ≥ 98% (HPLC). CAS No. 92954-90-0. Molecular formula: C24H21NO5. Mole weight: 403.60. | |
| Fumaric Acid Monoethyl Ester | Fumaric Acid Monoethyl Ester is an anti-psoriatic fumaric acid ester. Fumaric Acid Monoethyl Ester inhibited thymidine-14C incorporation into DNA by cultured human lymphocytes. Fumaric Acid Monoethyl Ester has been shown to evoke transient increase in intracellular free calcium concentration and inhibit proliferation of human keratinocytes. Group: Biochemicals. Alternative Names: (2E)-2-Butenedioic Acid 1-Ethyl Ester; (2E)-2-Butenedioic Acid Monoethyl Ester; Fumaric Acid Ethyl Ester; (E)-4-Ethoxy-4-oxo-2-butenoic Acid; Ethyl Hydrogen Fumarate; Monoethyl Fumarate; Monoethyl Fumerate; Monoethyl trans-2-Butenedioate. Grades: Highly Purified. CAS No. 2459-5-4. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Griseofulvin (Amudane, Grisovin, Fulvicin, Curling factor, Gricin, Grifulvin, Grisactin, Fulcin,. Norofulvin, Likuden, Idifulvin NSC 34533) | Griseofulvin is a spirobenzofuran produced by a number of Penicillium species, first isolated in the 1930s by Raistrick's group. Griseofulvin is a selective antifungal agent used to treat skin infections in animals and humans. Griseofulvin acts by binding to fungal tubulin and inhibiting the mitotic spindle. Griseofulvin's ability to bind to keratin is considered an important asect to the metabolite's access to dermatophytic fungi. More recently, griseofulvin has become an important phenotypic marker in Penicillium taxonomy. Group: Biochemicals. Grades: Highly Purified. CAS No. 126-07-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Histamine dihydrochloride | Histamine dihydrochloride is a reactive oxygen species ( ROS ) inhibitor. Histamine dihydrochloride can suppress ROS production and work together with IL-2 to activate T cells and NK cells, leading to immune activation in the tumor microenvironment, which consequently kills acute myeloid leukemia (AML) cells. Histamine dihydrochloride can cause a reduction in vaginal tetrazo reduction, increased epithelial growth, and heightened keratinization in mouse models of ovariectomy. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 56-92-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-B0722. | |
| Immobilized Proteinase K on Eupergit(R) C | Proteinase K hydrolyses keratin by cleaving peptide bonds adjacent to the carboxyl group of aliphatic and aromatic amino acids. Group: Enzymes. Synonyms: Tritirachium alkaline proteinase; Tritirachium album serine proteinase; proteinase K; Tritirachium album proteinase K; endopeptidase K; EC 3. 4. 21. 64; 39450-01-6. Enzyme Commission Number: EC 3. 4. 21. 64. Activity: >1500 U/g. Storage: 2-8°C. Form: powder (granular). Source: Tritirachium album. Tritirachium alkaline proteinase; Tritirachium album serine proteinase; proteinase K; Tritirachium album proteinase K; endopeptidase K; EC 3. 4. 21. 64; 39450-01-6; Immobilized Proteinase K. Cat No: NATE-1776. | |
| Ingenol-3-angelate | Ingenol 3-Angelate is a diterpenoid ester isolated from Euphorbia peplus that induces rapid cell death with keratinocytes and some cancer cell lines. Ingenol 3-Angelate is a protein kinase C activator that displays potent antileukemic activity. Ingenol 3-Angelate (ingenol mebutate) is used for treatment of actinic keratosis.Source:Semi-synthetic, the starting material ingenol was isolated from Euphorbia latyris. Group: Biochemicals. Grades: Highly Purified. CAS No. 75567-37-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H34O6. US Biological Life Sciences. | Worldwide |
| K6PC-5 | K6PC-5 is a Sphingosine kinase 1 (SphK1 or SK1) activator that increases sphingosine-1-phosphate (S1P) production, an active metabolite of sphingolipid. S1P can modulate multiple cellular responses including [Ca2+] signaling, growth, survival, and differentiation. K6PC-5 regulates both differentiation and proliferation of keratinocytes via [Ca2+]i responses through S1P production, which may be used for the treatment of skin disorders characterized by abnormal differentiation and proliferation, such as atopic dermatitis and psoriasis. Uses: Potential treatment of skin disorders with abnormal differentiation and proliferation. Synonyms: K6PC-5; K6PC 5; K6PC5; Dihydroxyisopropyl capryloylcaprylamide; Decanamide, 2-hexyl-N-(2-hydroxy-1-(hydroxymethyl)ethyl)-3-oxo. Grades: 98%. CAS No. 756875-51-1. Molecular formula: C19H37NO4. Mole weight: 343.5. | |
| Kojic acid | Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC 50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. CAS No. 501-30-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W050154. | |
| Lactosamine | Lactosamine forms the backbone of several cell surface glycans such as sialylated glycans or keratin sulfates. Also, it is a basic structural element of Lewis type, and human milk oligosaccharides. Group: Biochemicals. Grades: Highly Purified. CAS No. 13000-25-4. Pack Sizes: 5mg, 10mg. Molecular Formula: C12H23NO10, Molecular Weight: 341.31. US Biological Life Sciences. | Worldwide |
| L-Cystine | L-cystine is a sulfur-containing amino acid, which exists in small amounts in proteins, and is mostly contained in keratin of hair and fingers. Often used as a nutritional supplement, it is widely used in the breastfeeding of milk powder. It is a non-essential amino acid. CAS No. 56-89-3. Product ID: CDF4-0221. Molecular formula: C6H12N2O4S2. Category: Amino acid. Product Keywords: Amino Acids; L-Cystine; CDF4-0221; Amino acid; C6H12N2O4S2; 56-89-3. Grade: Food Grade. Color: White. EC Number: 200-296-3. Physical State: Powder/Solid. Solubility: 1 M HCl: 100 mg/mL. Storage: 2-8°C. Boiling Point: 468.2±45.0 °C(Predicted). Melting Point: >240 °C (dec.) (lit.). Density: 1.68. |  |
| Leukotriene B5 | Leukotriene B5 is a leukotriene generated from eicosapentaenoic acid (EPA). LTB5 exhibits less potent biological activity than LTB4, thus it can be identified as a LTB4 antagonist. Study showed that LTB5 inhibited LTB4-induced chemotaxis in vitro and LTB4-induced proliferation in cultured human epidermal keratinocytes. Synonyms: LTB5; 5,12-DiHEPE; 5S,12S-dihydroxy-6Z,8E,14Z,17Z-eicosapentanenoic acid. Grades: ≥98%. CAS No. 80445-66-5. Molecular formula: C20H30O4. Mole weight: 334.5. | |
| L-Histidine | L-Histidine is a proteinogenic amino acid and an essential amino acid required for histamine production. This positively charged amino acid is vital for growth, tissue repair, myelin sheath maintenance, and histamine synthesis. Histamine plays critical roles in immunity, gastric secretion, and more. L-Histidine is essential for blood cell production and tissue protection against radiation and heavy metals. L-Histidine plays a role as a metabolite and also acts as a cofactor in enzyme protection during protein synthesis. It is an L-enantiomer of histidine and is necessary for histamine synthesis and human development. L-Histidine finds applications in cell culture, metabolomics and biochemical research. Uses: L-histidine has been used as a component in agar plates containing 5-fluorocytosine (5-fc) for the selection of yeast transformants. it has also been used as a component of adult mouse keratinocyte growth medium. Group: Amino acids. Alternative Names: (S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773. CAS No. 71-00-1. Molecular formula: C6H9N3O2. Mole weight: 155.15. Canonical SMILES: N[C@@H](Cc1c[nH]cn1)C(O)=O. Density: 1.4±0.1 g/cm3. ECNumber: 200-745-3. Catalog: ACM71001-2. | |
| Lipoxin A4 | Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties [1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways [2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC 50 value of 25.74 nM [3]. Uses: Scientific research. Group: Natural products. Alternative Names: LXA4. CAS No. 89663-86-5. Pack Sizes: 25 μg (283.71 μM * 250 μL in Ethanol). Product ID: HY-113509. | |
| L-Tyrosine tert-butyl ester | L-Tyrosine tert-butyl ester is a protected form of L-Tyrosine. L-Tyrosine is an essential amino acid that exhibits in vitro antioxidant and antiradical activities. L-Tyrosine is used as a precursor to synthesize catecholamines in human keratinocytes, and also for the synthesis of proteins and thyroid hormones. Synonyms: L-Tyr-OtBu; H-Tyr-OtBu; tert-Butyl L-tyrosinate; L-tyrosine-COOBu-t; L-Tyrosine tert-butyl ester; t-butyl ester of tyrosine. Grades: ≥ 99% (HPLC). CAS No. 16874-12-7. Molecular formula: C13H19NO3. Mole weight: 237.30. | |
| Lugdunin | Lugdunin is an antibiotic peptide. Lugdunin inhibits bacteria by dissipating their membrane potential. Lugdunin is active against Gram-positive bacteria, such as S. aureus , and reduces S. aureus skin and nasal colonization. Lugdunin induces LL-37 and CXCL8/MIP-2 in human keratinocytes and mouse skin [1]. Uses: Scientific research. Group: Peptides. CAS No. 1989698-37-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P4200. | |
| mono-Ethyl fumarate | Monoethyl Fumarate is an anti-psoriatic fumaric acid ester. It was used in the preparation of photo-crosslinkable macromers. It was also used to synthesize Ugi/intramolecular Diels-Alder (IMDA) cycloaddition products. Uses: Fumaric acid monoethyl ester (quetiapine ep impurity r) is an anti-psoriatic fumaric acid ester. fumaric acid monoethyl ester inhibited thymidine-14c incorporation into dna by cultured human lymphocytes. fumaric acid monoethyl ester has been shown to evoke transient increase in intracellular free calcium concentration and inhibit proliferation of human keratinocytes. Synonyms: (E)-4-ethoxy-4-oxobut-2-enoic acid. Grades: > 95 %. CAS No. 2459-5-4. Molecular formula: C6H8O4. Mole weight: 144.13. | |
| Octinoxate | Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Octyl methoxycinnamate. CAS No. 5466-77-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B1234. | |
| rec β-Defensin 2 (human) | β-Defensin 2 (BD-2) (human), an antimicrobial peptide expressed throughout the epithelia of many organs, is induced when keratinocytes come into contact with Gram-negative bacteria or pro-inflammatory cytokines such as TNF-α and IL-1&beta. Elevated expression has been detected in lesional epidermal keratinocytes both in psoriasis and inflamed skin of mastitis. Synonyms: rec hBD-2; rec BD-2 (human); rec Defensin b-2 (human). Grades: ≥95% by HPLC. CAS No. 479328-13-7. | |
| Retinol palmitate | It can transdermally absorb, resist keratinization, stimulate the growth of collagen and elastin, and increase the thickness of epidermis and dermis. Enhances skin elasticity, effectively eliminates wrinkles, promotes skin renewal, maintains skin vitality. Group: Material of cosmetics. Alternative Names: Vitamin A palmitate, all-trans-Retinol palmitate. CAS No. 79-81-2. Molecular formula: C36H60O2. Mole weight: 524.86. Catalog: ACM79812. | |
| Robotnikinin | Robotnikinin is an inhibitor of Shh signaling that functions via repressing Gli-mediated transcription in primary human keratinocytes and synthetic human skin in a concentration-dependent manner. Synonyms: N-[(4-Chlorophenyl)methyl]-2-(5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl)acetamide. Grades: ≥97%. CAS No. 1132653-79-2. Molecular formula: C25H27ClN2O4. Mole weight: 455. | |
| Sauchinone | Sauchinone, coming from the herbs of Saururus chinensis(Lour.) Baill, is a useful adjunctive treatment for bacterial infection. Sauchinone inhibited oxidative stress, as assessed by stainings of 4-hydroxynonenal and nitrotyrosine: these events may have a role in its inhibitory effects on HSCs activation. Sauchinone attenuated CCl4-induced liver fibrosis and TGF-β1-induced HSCs activation, which might be, at least in part, mediated by suppressing autophagy and oxidative stress in HSCs. Sauchinone protects skin keratinocytes through inhibition of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK signaling via upregulation of oxidative defense enzymes. Uses: Anti-inflammatory/antibacterial. Synonyms: (5aR,7R,8S,8aR,14aS,14bR)-5a,6,7,8,8a,14b-Hexahydro-7,8-dimethyl-5H-Benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one; (5aα, 7α, 8β, 8aβ, 14aS*, 14bβ)-5a, 6, 7, 8, 8a, 14b-Hexahydro-7, 8-dimethyl-5H-benzo[kl]bis[1, 3]dioxolo[4, 5-b:4', 5'-g]xanthen-5-one. Grades: >98%. CAS No. 177931-17-8. Molecular formula: C20H20O6. Mole weight: 356.36. | |
| Sericin Protein | Unique glycoprotein isolated from natural silk produced by the silk worm Bombyx mori. Has strong affinity to keratin and forms a natural semi-occlusive, protecting anti-wrinkle film on the skin surface imparting an immediate, long lasting, smooth, silky feeling. Sericin provides excellent film-forming, conditioning, and anti-wrinkle properies. It reduces significantly transepidermal water loss and skin irritation. Smoothing and moisturizing activities that persist even after washing leaving the skin or scalp silky and smooth. Uses: Anti-aging and anti-wrinkle creams lotions, and serums. all kinds of conditioning hair care products. Group: Skin actives. CAS No. 60650-88-6 / 7732-18-5 / 77-92-9 / 24634-61-5. Appearance: Yellowish-brown aqueous liquid. Catalog: CI-SC-0724. | |
| Sericin Protein, Hydrolyzed | Unique glycoprotein isolated from natural silk produced by the silk worm Bombyx mori. Hydrolzyed (fragmented) for better solubility and skin-penetration. Has strong affinity to keratin and forms a natural semi-occlusive, protecting anti-wrinkle film on the skin surface imparting an immediate, long lasting, smooth, silky feeling. Hydrolyzed sericin provides excellent film-forming, conditioning, and anti-wrinkle properties. It reduces significantly transepidermal water loss and skin irritation. Smoothing and moisturizing activities that persist even after washing leaving the skin or scalp silky and smooth. Uses: Anti-aging and anti-wrinkle creams lotions, and serums. all kinds of conditioning hair care products. Group: Skin actives. CAS No. 60650-88-6 / 7732-18-5 / 122-99-6 / 70445-33-9. Appearance: Amber aqueous liquid. Catalog: CI-SC-0723. | |
| Sodium diethyl phosphate | Sodium diethyl phosphate can be used in a cosmetic composition for treating keratin materials. Synonyms: Diethyl Phosphate Sodium Salt; Phosphoric acid, diethyl ester, sodium salt. CAS No. 2870-30-6. Molecular formula: C4H10NaO4P. Mole weight: 176.08. | |
| Suberoyl Bis-hydroxamic Acid | Histone deacetylase inhibitor. A cell-permeable inhibitor of HDAC1 and HDAC3. Shown to suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells. Group: Biochemicals. Alternative Names: N1, N8-Dihydroxyoctane diamide. Grades: Highly Purified. CAS No. 38937-66-5. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| Tacalcitol monohydrate | Tacalcitol is a vitamin D analogue that promotes normal bone development by regulating calcium. It modulates immunological and inflammatory processes and induces nerve growth factor production in epidermal keratinocytes. Synonyms: 1,24(R)-Dihydroxyvitamin D3, monohydrate. Grades: >98%. CAS No. 93129-94-3. Molecular formula: C27H46O4. Mole weight: 434.65. | |
| Tachysterol | Bioactive, synthetic vitamin D3 analog; exhibits anti-proliferative effect on keratinocytes. Anti-psoriatic. Group: Biochemicals. Alternative Names: (1S)-3-[(1E)-2-[(1R,3aR,7aR)-2,3,3a,6,7,7a-Hexahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-1H-inden-4-yl]ethenyl]-4-methyl-3-cyclohexen-1-ol; (3 β,6E,22E)-9,10-Secoergosta-5(10),6,8,22-tetraen-3-ol; Provitamin D; Tachysterin2; Tachysterol2. Grades: Highly Purified. CAS No. 115-61-7. Pack Sizes: 1mg. Molecular Formula: C??H??O, Molecular Weight: 396.65. US Biological Life Sciences. | Worldwide |
| TB500 | TB500 is a synthetic version of an active region of thymosin β 4. TB500 is claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation [1]. Uses: Scientific research. Group: Peptides. CAS No. 885340-08-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0170. | |
| TB500 acetate | TB500 acetate, a synthetic version of the active region of thymosin β4, has been reported to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition, and reduce inflammation. Synonyms: TB 500 acetate; Frag17-23 acetate; N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-threonyl-L-alpha-glutamyl-L-threonyl-L-glutamine acetic acid; Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-OH.CH3CO2H. Grades: ≥95%. Molecular formula: C40H72N10O16. Mole weight: 949.06. | |
| Terrein (NSC 291308, 4,5-Dihydroxy-3-(1-propenyl)-2-cyclopenten-1-one) | Antibacterial. Phytotoxin. Melanogenesis inhibitor by reducing tyrosinase production via extracellular signal-regulated protein kinase (ERK) activation. Keratinocyte and epidermis proliferation inhibitor. Mycotoxin. Anti-inflammatory modulator in pulpal inflammation. Angiogenesis inhibitor through angiogenin secretion inhibition. Collagen-induced platelet aggregation inhibitor. Antioxidant agent that enhances osseointegration by decreasing the level of ROS and having a potentially synergistic effect on osteoblast differentiation. Proteasome inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 582-46-7. Pack Sizes: 1mg, 5mg, 10mg. US Biological Life Sciences. | Worldwide |
| TGF α (1-50) (rat) | TGF α (1-50) (rat) was originally identified as an agent that can reversibly confer a transformed phenotype on normal non-tumor cells, such as normal rat renal fibroblasts. This activity requires the presence of transforming growth factor-β (TGF-β), which enhances the effects of TGF-α through a separate receptor. TGF-α is synthesized by monocytes, keratinocytes and a variety of tissues and tumors. (approx. ED50 = 0.2 ng/mL). Synonyms: H-Val-Val-Ser-His-Phe-Asn-Lys-Cys-Pro-Asp-Ser-His-Thr-Gln-Tyr-Cys-Phe-His-Gly-Thr-Cys-Arg-Phe-Leu-Val-Gln-Glu-Glu-Lys-Pro-Ala-Cys-Val-Cys-His-Ser-Gly-Tyr-Val-Gly-Val-Arg-Cys-Glu-His-Ala-Asp-Leu-Leu-Ala-OH (Disulfide bridge: Cys8-Cys21, Cys16-Cys32, Cys34-Cys43); Transforming Growth Factor-α (1-50) from rat. CAS No. 89899-53-6. Molecular formula: C244H361N71O71S6. Mole weight: 5617.38. | |
| trans 2-Phenylcyclopropylamine Hydrochloride (Tranylcypromine, trans 2-Amino-1-phenyl-cyclopropane Hydrochloride) | A non-selective inhibitor of monoamine oxidase (MAO) and prostacyclin synthase. Potently suppresses the enzymatic activity of Lysine-Specific Demethylase 1 (LSD1) (IC50 <2uM for BHC110/LSD1). When combined with GSK-3 Inhibitor CHIR99021, causes reprogramming of human primary keratinocyte transduced with two factors, Oct4 and Klf4. Group: Biochemicals. Alternative Names: Tranylcypromine; trans 2-Amino-1-phenyl-cyclopropane Hydrochloride. Grades: Highly Purified. CAS No. 1986-47-6. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Tranylcypromine Hemisulfate (Trans (±) -2-Phenyl cyclopropanamine, Hemisulfate; SKF trans-355; 2-PCPA) | An inhibitor of monoamine oxidase (MAO) and prostacyclin synthase. Potently suppresses the enzymatic activity of Lysine-Specific Demethylase 1 (LSD1) (IC50 <2uM for BHC110/LSD1). When combined with GSK-3 Inhibitor CHIR99021, causes reprogramming of human primary keratinocyte transduced with two factors, Oct4 and Klf4. Group: Biochemicals. Alternative Names: Trans (±) -2-Phenyl cyclopropanamine, Hemisulfate; SKF trans-355; 2-PCPA. Grades: Highly Purified. CAS No. 13492-01-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Undecane | Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α [. Uses: Scientific research. Group: Natural products. CAS No. 1120-21-4. Pack Sizes: 10 mM * 1 mL; 10 g; 25 g. Product ID: HY-N8593. | |
| Undecanoic acid | Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Undecanoate; Hendecanoic acid. CAS No. 112-37-8. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W004282. | |
| Urea | Pharmacopeia & Metrological Institutes Standards; Pharma & Vet Compounds & Metabolites; Pharma & Vet Compounds & Metabolites; British Pharmacopoeia; European Pharmacopoeia (Ph. Eur.); Impurity Standards; Pharmacopoeial Standards. Uses: For analytical and research use. Group: Reagents. Alternative Names: Carbamide, Cellpaste K 4, Pastaron 20, Urepeal,Urea, Onyster, Ultra Low Biuret Urea, Carmol 40, Isourea, Pastaron soft, AdBlue, DEF (diesel exhaust fluid), ESN, Nutraplus, Aquacare, Elaqua XX, Urepearl, Varioform II, Carbonyl diamide, Basodexan, Uroderm, Rubinol ST 010, UR, Optigen II, Carbamimidic acid, B-I-K, Onychomal, Ureophil, Hyanit, Duration III, Pastaron, AUS 32, Ureaphil, Keratinamin Kowa, NSC 34375, Pastaron 20 soft, Benural 70, Pastaron 10, Urea perhydrate, Urepeal L, Urevert, Keratinamin, Eucerin 10% Urea Lotion, Optigen 1200, SGN 250, Low Biuret Urea, Cellton NP, Pseudourea, Aquadrate, Uria, DEF, Diesel exhaust fluid. CAS No. 57-13-6. Pack Sizes: 200MG. IUPAC Name: urea. |  |
| Urea-d4 | Urea-d4. Group: Biochemicals. Alternative Names: Aquacare-d4; Aquadrate-d4; B-I-K-d4; Basodexan-d4; Benural 70-d4; Carbamide-d4; Carbamimidic Acid-d4; Carbonyl Diamide-d4; Carmol 40-d4; Cellpaste K 4-d4; Cellton NP-d4; Duration III-d4; ESN-d4; Elaqua XX-d4; Eucerin 10% Urea Lotion-d4; Hyanit-d4; Isourea-d4; Keratinamin-d4; Keratinamin Kowa-d4; Low Biuret Urea-d4; NSC 34375-d4; Nutraplus-d4; Onychomal-d4; Optigen 1200-d4; Optigen II-d4; Pastaron-d4; Pastaron 10-d4; Pastaron 20-d4; Pastaron 20 soft-d4; Pastaron soft-d4; Pseudourea-d4; Rubinol ST 010-d4; SGN 250-d4; UR-d4; Ultra Low Biuret Urea-d4; Urea Perhydrate-d4; Ureaphil-d4; Ureophil-d4; Urepeal-d4; Uria-d4; Uroderm-d4; Varioform II-d4. Grades: Highly Purified. CAS No. 1433-11-0. Pack Sizes: 1g. Molecular Formula: CD4N2O, Molecular Weight: 64.08. US Biological Life Sciences. | Worldwide |
| Voriconazole N-oxide | Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Voriconazole oxynitride. CAS No. 618109-05-0. Pack Sizes: 1 mg. Product ID: HY-137989. | |
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