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| Product | Description | |
|---|---|---|
| Luciferase | Luciferase from Vibrio fischeri has also been used in a study to investigate the sensitivity of dark mutants of various strains of luminescent bacteria to reactive oxygen species. Uses: Scientific research. Group: Fluorescent dye. CAS No. 9014-00-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1004. |  |
| Luciferase | Luciferase is an analytical enzyme used as a component of lysis solution to measure luminescence signals. It has been used to investigate the sensitivity of dark mutants of various luminescent bacterial strains to reactive oxygen species. Synonyms: EC 1.14.14.3; Bacterial Luciferase; Luciferase from Photobacterium fischeri. Grades: >95%. CAS No. 9014-00-0. |  |
| Luciferase, firefly | Luciferase, firefly is a bioluminescent enzyme responsible for bioluminescence in fireflies and click beetles. Synonyms: Luciferase from Photinus pyralis (firefly). Grades: >98%. CAS No. 61970-00-1. | |
| Luciferase, firefly | Luciferase, firefly is the light-emitting enzyme responsible for the bioluminescence of fireflies and click beetles. Uses: Scientific research. Group: Peptides. CAS No. 61970-00-1. Pack Sizes: 1 mg. Product ID: HY-P1004A. | |
| Luciferase from E. coli, Recombinant | Luciferase is an enzyme that catalyzes production of light from luciferin in the presence of Mg2+-ATP and oxygen. The reaction of this enzyme with luciferin, ATP, and O2 results in the emission of light. Luciferase activity can be inhibited by general anesthetics including isoflurane and ketamine/medetomidine thereby affecting the sensitivity of bioluminescence imaging. Group: Enzymes. Synonyms: Photinus-luciferin 4-monooxygenase (ATP-hydrolysing); firefly luciferase; luciferase (firefly luciferin); Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing); firefly luciferin luciferase; Photinus pyralis luciferase; EC 1.13.12.7; 61970-00-1. Enzyme Commission Number: EC 1.13.12.7. Luciferase. Mole weight: ca. 60 kDa. Activity: > 1.0 x 10^9 relative light units (RLU)/mg lyophilizate Specific activity: 1.4 x 10^11 RLU/mg purified protein. Stability: stable at 25°C for at least 5 days (liquid form). Appearance: White lyophilizate. Storage: at -20°C. Source: E. coli. Species: E. coli. Photinus-luciferin 4-monooxygenase (ATP-hydrolysing); firefly luciferase; luciferase (firefly luciferin); Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing); firefly luciferin luciferase; Photinus pyralis luciferase; EC 1.13.12.7; 61970-00-1. Cat No: NATE-1253. |  |
| Luciferase from Photinus pyralis (firefly), Recombinant | Firefly luciferase is an enzyme that catalyzes production of light from luciferin in the presence of Mg2+-ATP and oxygen. The reaction of this enzyme with luciferin, ATP, and O2 results in the emission of light. Luciferase activity can be inhibited by general anesthetics including isoflurane and ketamine/medetomidine thereby affecting the sensitivity of bioluminescence imaging. Applications: The reaction of this enzyme with luciferin, atp, and o2 results in the emission of light. luciferase can be used to detect trace amounts of atp. firefly luciferase is also one of the most commonly utilized reporter genes for the study of gene expression. the bioluminescent rea...pe I , > 5 ,000 ,000 units/mg protein; Type II, 15-30×106 light units/mg protein. Storage: -70°C. Form: Type I, Supplied as a solution in 50 mM Tris HCl pH 8.0, 1 mM dithiothreitol, 1 mM EDTA, and 10% (v/v) glycerol; Type II, Lyophilized powder approximately 20% protein; balance is primarily NaCl, HEPES buffer salts, and carbohydrate. Source: E. coli. Species: Photinus pyralis (firefly). Photinus-luciferin 4-monooxygenase (ATP-hydrolysing); firefly luciferase; luciferase (firefly luciferin); Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing); firefly luciferin luciferase; Photinus pyralis luciferase; EC 1.13.12.7; 61970-00-1. Cat No: NATE-0424. | |
| Luciferase from Vibrio fischeri | Luciferase from Vibrio fischeri. Group: Biochemicals. Grades: Highly Purified. CAS No. 9014-00-0. Pack Sizes: 100mg, 250mg, 500mg. US Biological Life Sciences. |  Worldwide |
| Luciferase from Vibrio fischeri (Photobacterium f) | lyophilized powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Luciferase-IN-4 | Luciferase-IN-4 (Compound 6b) is an inhibitor for luciferase with IC 50 of 4.1 μM. Luciferase-IN-4 inhibits purified luciferase in P. pyralis with IC 50 of 2.0 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1020413-85-7. Pack Sizes: 1 mg. Product ID: HY-161475. | |
| AMPK Signaling Activator XIII, ZLN005 (2-(4-tert-Butylphenyl)-1H-benzo[d]imidazole, 2-(4-(2-Methyl-2-propanyl)phenyl)-1H-benzimidazole, Luciferase Inhibitor IV) | A cell-permeable benzimidazole that, in addition to its inhibitory potency against luciferase activity (IC50 <10nM), also activates AMPK signaling by increasing cellular ADP/ATP ratio via mitochondria respiration upcoupling, effectively activating AMPK & PGC-1alpha in muscle, but not liver, cell types both in cultures (5-20uM in rat L6 myotubes) in vitro and in db/db mice (15mg/kg/day via p.o.) in vivo. Reported to improve glucose and insulin tolerance of db/db mice without any apparent effects on body weight or food intake. Group: Biochemicals. Grades: Highly Purified. CAS No. 4529-96-8. Pack Sizes: 25mg. Molecular Formula: C??H??N?. US Biological Life Sciences. | Worldwide |
| Anti-Luciferase antibody, Mouse monoclonal | clone LUC-1, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| bacterial luciferase | The reaction sequence starts with the incorporation of a molecule of oxygen into reduced FMN bound to the enzyme, forming luciferase peroxyflavin. The peroxyflavin interacts with an aliphatic long-chain aldehyde, producing a highly fluorescent species believed to be luciferase hydroxyflavin. The enzyme is highly specific for reduced FMN and for long-chain aliphatic aldehydes with eight carbons or more. The highest efficiency is achieved with tetradecanal. cf. EC 1.13.12.18, dinoflagellate luciferase. Group: Enzymes. Synonyms: aldehyde monooxygenase; luciferase; Vibrio fischeri luciferase; alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal monooxygenase (FMN); aldehyde,FMNH2:oxygen oxidoreductase (1-hyd. Enzyme Commission Number: EC 1.14.14.3. CAS No. 9014-00-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0927; bacterial luciferase; EC 1.14.14.3; 9014-00-0; aldehyde monooxygenase; luciferase; Vibrio fischeri luciferase; alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal monooxygenase (FMN); aldehyde,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing). Cat No: EXWM-0927. | |
| Biotinylated Luciferase from E. coli, Recombinant | Luciferase is an enzyme that catalyzes production of light from luciferin in the presence of Mg2+-ATP and oxygen. The reaction of this enzyme with luciferin, ATP, and O2 results in the emission of light. Luciferase activity can be inhibited by general anesthetics including isoflurane and ketamine/medetomidine thereby affecting the sensitivity of bioluminescence imaging. Group: Enzymes. Synonyms: Photinus-luciferin 4-monooxygenase (ATP-hydrolysing); firefly luciferase; luciferase (firefly luciferin); Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing); firefly luciferin luciferase; Photinus pyralis luciferase; EC 1.13.12.7; 61970-00-1. Enzyme Commission Number: EC 1.13.12.7. Luciferase. Mole weight: ca. 70 kDa. Activity: > 1.0 x 10^10 relative light units (RLU)/ml Specific activity: 1.9 x 10^11 RLU/mg purified protein. Stability: stable at 25°C for at least one week (liquid form). Appearance: Liquid form. Storage: at -20°C. Source: E. coli. Species: E. coli. Photinus-luciferin 4-monooxygenase (ATP-hydrolysing); firefly luciferase; luciferase (firefly luciferin); Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing); firefly luciferin luciferase; Photinus pyralis luciferase; EC 1.13.12.7; 61970-00-1. Cat No: NATE-1254. | |
| dinoflagellate luciferase | A luciferase from dinoflagelates such as Gonyaulax polyedra, Lingulodinium polyedrum, Noctiluca scintillans, and Pyrocystis lunula. It is a single protein with three luciferase domains. The luciferin is strongly bound by a luciferin binding protein above a pH of 7. Group: Enzymes. Synonyms: (dinoflagellate luciferin) luciferase; Gonyaulax luciferase. Enzyme Commission Number: EC 1.13.12.18. CAS No. 303183-71-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0610; dinoflagellate luciferase; EC 1.13.12.18; 303183-71-3; (dinoflagellate luciferin) luciferase; Gonyaulax luciferase. Cat No: EXWM-0610. | |
| Firefly luciferase-IN-1 | Firefly luciferase-IN-1 (compound 48) is a highly potent and reversible inhibitor of firefly luciferase with an IC50 value of 0.25 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2765796-41-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-155945. | |
| Native Photinus pyralis (firefly) Luciferase | Firefly luciferase is an enzyme that catalyzes production of light from luciferin in the presence of Mg2+-ATP and oxygen. The reaction of this enzyme with luciferin, ATP, and O2 results in the emission of light. Luciferase activity can be inhibited by general anesthetics including isoflurane and ketamine/medetomidine thereby affecting the sensitivity of bioluminescence imaging. Applications: The reaction of this enzyme with luciferin, atp, and o2 results in the emission of light. luciferase can be used to detect trace amounts of atp. firefly luciferase is also one of the most commonly utilized reporter genes for the study of gene expression. the bioluminescent reaction ... been used in a study to identify the different characteristics of reporter genes in whole-cell bacterial sensors. luciferase from photinus pyralis has also been used in a study to develop a novel bioluminogenic assay for α-chymotrypsin. Group: Enzymes. Synonyms: Photinus-luciferin 4-monooxygenase (ATP-hydrolysing); firefly luciferase; luciferase (firefly luciferin); Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing); firefly luciferin luciferase; Photinus pyralis luciferase; EC 1.13.12.7; 61970-00-1. Enzyme Commission Number: EC 1.13.12.7. CAS No. 9014-00-0. Luciferase. Mole weight: mol wt 120 kDa (two subunits). Form: Lyophilized powder appr | |
| Native Photobacterium phosphoreum (Lux) Bacterial Luciferase | P. phosphoreum. Applications: Bacterial luciferase is purified from a photobacterium phosphoreum strain isolated from squid by our team and selected for its brightest luminescence. the luxab gene was amplified by pcr and cloned. the sequences of cloned α and β subunits have shown 94% and 92% identity to p24113 and p12744 proteins of photobacterium phosphoreum (swissprot entry). Group: Enzymes. Synonyms: aldehyde monooxygenase; luciferase; Vibrio fischeri luciferase; alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal monooxygenase (FMN); aldehyde,FMNH2:ox... presence of limiting concentrations of NADH substrate, light intensity is proportional to NAD(P)H concentration. The coupling of bacterial luciferase to FMN-NAD(P)H oxidoreductase has been used to provide ultrasensitive analytical tools for the quantification of NAD(P)H and the substrates of NADH-, NADPH- dependent enzymes (e.g. glucose, lactate, malate, ethanol, sorbitol, oxaloacetate).Bacterial Luciferase can be used for NAD(P)H quantification or in dehydrogenase-coupled assays.The enzyme is provided lyophilized, alone or with lyophilized FMN-reductase. Species: Luciferase. aldehyde monooxygenase; luciferase; Vibrio fischeri luciferase; alkanal,reduced-FMN:ox | |
| Native Vibrio fischeri (Photobacterium f) Luciferase | In enzymology, an alkanal monooxygenase (FMN-linked) (EC 1.14.14.3) is an enzyme that catalyzes the chemical reaction:RCHO + reduced FMN + O2<-> RCOOH + FMN + H2O + hnu. The 3 substrates of this enzyme are RCHO, reduced FMN, and O2, whereas its 4 products are RCOOH, FMN, H2O, and hn. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor. Applications: Luciferase from vibrio fischeri has been used in a s...; aldehyde monooxygenase; luciferase; Vibrio fischeri luciferase; alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing); EC 1.14.14.3; 9014-00-0. Enzyme Commission Number: EC 1.13.12.7. CAS No. 9014-00-0. Luciferase. Form: lyophilized powder. Source: Vibrio fischeri (Photobacterium f). alkanal monooxygenase (FMN); bacterial luciferase; aldehyde monooxygenase; luciferase; Vibrio fischeri luciferase; alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing); EC 1.14.14.3; 9014-00-0. Cat No: NATE-0423. | |
| 17α-Ethinyl-17 β-acetoxy-3,5-estradiene | 17α-Ethinyl-17 β-acetoxy-3,5-estradiene is derived from Ethynodiol (E932120), which is a steroidal progestin that inhibits luciferase expression. Also, it is an impurity of the drug Norethindrone Acetate (N675990). Group: Biochemicals. Grades: Highly Purified. CAS No. 64850-62-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H28O2, Molecular Weight: 324.459999999999. US Biological Life Sciences. | Worldwide |
| 1,9-Nonanediol | 1,9-Nonanediol is found to be a general anesthetic that can inhibit the firefly luciferase enzyme from Photinus pyralis by competing with its normal substrate firefly luciferin. 1,9-Nonanediol can also inhibit the bacterial luciferase enzyme from Vibrio Harveyi by competing with the substrate n-decanal. Group: Biochemicals. Grades: Highly Purified. CAS No. 3937-56-2. Pack Sizes: 10g, 50g. Molecular Formula: C9H20O2, Molecular Weight: 160.25. US Biological Life Sciences. | Worldwide |
| 2-Chlorobenzaldehyde Oxime | 2-Chlorobenzaldehyde Oxime is a chemical reagent used in the synthesis of antimicrobial hydroxamates which are potential inhibitors of deoxy-D-xylulose 5-phosphate synthase inhibiting growth of influenzae. Also used in the preparation ofsubstituted oxazole based firefly luciferase inhibitors. Group: Biochemicals. Alternative Names: 2-Chlorobenzaldehyde oxime; 2-Chlorobenzaldoxime; NSC 61415; o-Chlorobenzaldehyde oxime; o-Chlorobenzaldoxime. Grades: Highly Purified. CAS No. 3717-28-0. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| 2-?Propyl-1,?3-?Dioxolane-?2-?acetic Acid | 2-?Propyl-1,?3-?Dioxolane-?2-?acetic Acid is an intermediate in synthesizing N-(Ketocaproyl)-L-homoserine Lactone (K180750), an autoinducer of P. fischeri luciferase. A specific genetic regulator that is unrelated to at least one of the enzyme systems that it induces, and it acts after excretion and accumulation in the extracellular medium. Group: Biochemicals. Grades: Highly Purified. CAS No. 5735-99-9. Pack Sizes: 500mg, 1g. Molecular Formula: C8H14O4. US Biological Life Sciences. | Worldwide |
| 2-Propyl-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-1,3-dioxolane-2-acetamide | 2-Propyl-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-1,3-dioxolane-2-acetamide is an intermediate in synthesizing N-(Ketocaproyl)-L-homoserine Lactone (K180750), an autoinducer of P. fischeri luciferase. A specific genetic regulator that is unrelated to at least one of the enzyme systems that it induces, and it acts after excretion and accumulation in the extracellular medium. Group: Biochemicals. Grades: Highly Purified. CAS No. 1083287-09-5. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H19NO5. US Biological Life Sciences. | Worldwide |
| 2-Undecanone | 2-Undecanone is a volatile organic compound, which inhibits the DnaKJE-ClpB bichaperone dependent refolding of heat-inactivated bacterial luciferases. 2-Undecanone inhibits lung tumorigenesis [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 112-12-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W016969. | |
| 5-(4-Methoxyphenyl)-2-pyridinamine | Used in the preparation of luciferase inhibitors, substituted triazoles as antifungal agents and PhIP (A617000) metabolites and derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 503536-75-2. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 6-Amino-D-luciferin | 6-Amino-D-luciferin is a D-luciferin (HY-12591A) with its 6-position hydroxyl group substituted with an amino group. D-luciferin is the natural substrate of the enzyme luciferase (Luc) [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 161055-47-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-126994. | |
| 6-Iodonordihydrocapsaicin | 6-Iodonordihydrocapsaicin is a potent and competitive vanilloid TRPV1 (VR1) receptor antagonist with IC50 value of 10 nM. It inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons. It also inhibits guinea pig bladder and trachea contractions in vitro. It may induce luciferase gene expression. Synonyms: N-[(4-Hydroxy-2-iodo-5-methoxyphenyl)methyl]nonanamide; 6-I-CPS. Grades: ≥99% by HPLC. CAS No. 859171-97-4. Molecular formula: C17H26INO3. Mole weight: 419.30. | |
| AkaLumine hydrochloride | AkaLumine hydrochloride is a D-luciferin (HY-12591A) analogue with a Km of 2.06 ?M for recombinant firefly luciferase (Fluc) protein. AkaLumine hydrochloride emits near-infrared (NIR) light (?max=677?nm) in reactions with native Fluc. AkaLumine hydrochloride has high tissue-penetration and increases detection sensitivity from deep-tissue targets[1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2558205-28-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112641A. | |
| Alisol B 23-Acetate | Alisol B 23-acetate (23-Acetylalismol B), a natural triterpenoid, produces protective effects against EE-induced cholestasis, due to FXR-mediated gene regulation.IC50 Value:Target: Anti-hepatotoxic natural product.In vitro: Alisol-B 23-acetate has an effect on FXR activation in a dose-dependent manner using luciferase reporter assay in HepG2 cells.In vivo: In alisol B 23-acetate-treated mice, the changes in transporters and enzymes, as well as ameliorative liver histology were abrogated by FXR antagonist guggulsterone. Alisol B 23-acetate treatment in a dose-dependent manner resulted in protection against hepatotoxicity induced by CCl4via FXR activation. Through FXR activation, alisol B 23-acetate promoted hepatocyte proliferation via an induction in hepatic levels of FoxM1b, Cyclin D1 and Cyclin B1. Alisol B 23-acetate also reduced hepatic bile acids through a decrease in hepatic uptake transporter Ntcp, bile acid synthetic enzymes Cyp7a1, Cyp8b1, and an increase in efflux transporter Bsep, Mrp2 expression. In addition, alisol B 23-acetate induced the expression of STAT3 phosphorylation, and STAT3 target genes Bcl-xl and SOCS3, resulting in decreased hepatocyte apoptosis. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: White powder. CAS No. 26575-95-1. Molecular formula: C32H50O5. Mole weight: 514.8. Purity: 0.98. IUPACName: [1-(3,3-dimethyloxiran-2-yl)-3-[(8S,1 |  |
| CCG-100602 | CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells with an IC50 value of 9.8 μM. CCG-100602 specifically blocks the nuclear localization of MRTF-A, thereby inhibiting the fibrogenic transcription factor SRF. Synonyms: CCG-100602; 1207113-88-9; 1-[3,5-bis(trifluoromethyl)benzoyl]-N-(4-chlorophenyl)piperidine-3-carboxamide; CHEMBL603141; compound 4g [PMID: 19963382]; 1-(3,5-bis(trifluoromethyl)benzoyl)-N-(4-chlorophenyl)piperidine-3-carboxamide; CCG100602; CCG 100602; GTPL6764; SCHEMBL1534209; BDBM50436237; AKOS040744973; MS-28902; HY-120855; CS-0079376; Q27075763; [3,5-bis(trifluoromethyl)benzoyl]-N-(4-chlorophenyl)piperidine-3-carboxamide; 1-[3,5-bis (trifluoromethyl)benzoyl]-N-(4-chlorophenyl)-3-piperidinecarboxamide. Grades: 98%. CAS No. 1207113-88-9. Molecular formula: C21H17ClF6N2O2. Mole weight: 478.8. | |
| CCG-203971 | CCG-203971 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC50 =6.4 ?M). CCG-203971 inhibits PC-3 cell migration with an IC50 of 4.2 ?M. Potential anti-metastasis Agent[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1443437-74-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108361. | |
| Cetrorelix Acetate | Cetrorelix Acetate is the acetate salt of cetrorelix, which is a potent and synthetic peptide antagonist of gonadotropin-releasing hormone (GnRH) receptor antagonist with IC50 value of 1.21 nM. It binds to radioligand murine LTK- cells with Kd value of 0.2 nM. It inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH. It suppresses production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. It prevents ovulation during in vitro fertilization. It causes prepubertal reduction in bone density, bone strength and bone modeling. It was used as a therapeutic agent for the treatment of blood cancers such as multiple myeloma (MM). It is also used to treat hormone-sensitive cancers of the breast and prostate. It also has antidepressant and anxiolytic activity in vivo. Uses: Fertility agents, female. Synonyms: D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-, acetate (1:x); D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-, acetate (salt); Cetrotid; Cetrotide; D 20761; NS 75A; Ovurelix; SB 075 acetate; Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2.CH3CO2H. Grades: >98%. CAS No. 145672-81-7. Molecular formula: C70H92ClN17O14.xC2H4O2. Mole weight: 1431.06 (free base). | |
| CH-223191 | CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor ( AhR ). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC 50 of 0.03 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301326-22-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12684. | |
| CID 1375606 | CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27. Promotes recruitment of β-arrestin 2 to chimeric GPR27V2 and wild-type GPR27 in a firefly luciferase complementation assay (pEC50 values are 6.34 and 5.1, respectively). GPR27 is characterized by a high level of conservation among vertebrates and a predominant expression in the central nervous system. In addition, it has recently been linked to insulin secretion. Synonyms: 2,4-Dichloro-N-(phenylcarbamoyl)phenylbenzamide; 2,4-Dichloro-N-(4-(phenylcarbamoyl)phenyl)benzamide. Grades: ≥98% by HPLC. CAS No. 313493-80-0. Molecular formula: C20H14Cl2N2O2. Mole weight: 385.24. | |
| Coelenteramine 400a | Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm[1][2]. Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET)[3]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Coelenterazine 400a; Bisdeoxycoelenterazine. CAS No. 70217-82-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-118462. | |
| Coelenterazine | Coelenterazine is a luciferin, a light-emitting biomolecule that serves as a substrate for luciferases or as a constituent of photoproteins, including aequorin.1 The oxidation of coelenterazine to coelenteramide is accompanied by emission of blue light (emission maximum, 460-470 nm). Luciferase-mediated oxidation of coelenterazine or a derivative is used as an energy donor, typically to a form of green or yellow fluorescent protein, in bioluminescent resonance energy transfer studies.2,3 Alternatively, the calcium-mediated release of coelenterazine from aequorin, followed by non-enzymatic oxidation of this compound, results in bioluminescence. As light emission depends on both calcium and cellular redox status, this reaction is used to non-fluorescently detect changes in calcium level and redox status.4,5. Group: Biochemicals. Alternative Names: 3,2-Dihydro-2-(p-hydroxybenzyl)-6-(p-hydroxyphenyl)-8-benzylimidazolo[1,2-a]pyrazin-3-one; CLZN; Preluciferin; Luciferin; 6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-imidazo[1,2-a]pyrazin-3(7H)-one. Grades: Highly Purified. CAS No. 55779-48-1. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C??H??N?O?, Molecular Weight: 423.46. US Biological Life Sciences. | Worldwide |
| Coelenterazine | Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 55779-48-1. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18743. | |
| CP21R7 | CP21R7 is a potent and selective GSK3β inhibitor. It acts as an activator of stem cells prior to the induction of differentiation of stem cells to endothelial and smooth muscle cells. Uses: Cp21r7 is a selective gsk-3β inhibitor which could probably influence luciferase activity at some extent. Synonyms: 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione. Grades: >98%. CAS No. 125314-13-8. Molecular formula: C19H15N3O2. Mole weight: 317.34. | |
| CycLuc1 | CycLuc1 is a blood-brain barrier permeable luciferase substrate that displays near-infrared (NIR) emission with a peak luminescence wavelength of 599 nm. CycLuc1 can be used for in vivo bioluminescence imaging[1][2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1247879-16-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111653. | |
| Cypridina-luciferin 2-monooxygenase | Cypridina is a bioluminescent crustacea. The luciferins (and presumably the luciferases, since they cross-react) of some luminous fish (e.g. Apogon, Parapriacanthus, Porichthys) are apparently similar. The enzyme may be assayed by measurement of light emission. Group: Enzymes. Synonyms: Cypridina-type luciferase; luciferase (Cypridina luciferin); Cypridina luciferase. Enzyme Commission Number: EC 1.13.12.6. CAS No. 61969-99-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0619; Cypridina-luciferin 2-monooxygenase; EC 1.13.12.6; 61969-99-1; Cypridina-type luciferase; luciferase (Cypridina luciferin); Cypridina luciferase. Cat No: EXWM-0619. | |
| Decyl aldehyde | Decyl aldehyde is a simple ten-carbon aldehyde. Decyl aldehyde is a bacterial luciferase substrate. Uses: Scientific research. Group: Natural products. CAS No. 112-31-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-W012570. | |
| D-Luciferin | D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP [1]. We of er the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B). Uses: Scientific research. Group: Fluorescent dye. Alternative Names: D-(-)-Luciferin; Firefly luciferin; Beetle Luciferin. CAS No. 2591-17-5. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-12591A. | |
| D-Luciferin-6-O b-D-galactopyranoside | D-Luciferin-6-O b-D-galactopyranoside is a versatile tool in compound utilized for studying the activity of luciferase enzymes in various research applications. This compound is commonly employed in in vitro and in vivo bioluminescence imaging assays is aiding in the investigation of gene expressions, protein interactions and visualization of cellular processes. Synonyms: 6-O-(b-D-Galactopyranosyl)luciferin. CAS No. 131474-38-9. Molecular formula: C17H18N2O8S2. Mole weight: 442.47. | |
| D-Luciferin-6-O b-D-glucopyranoside | D-Luciferin-6-O b-D-glucopyranoside is a crucial compound acting as a useful substrate for luciferase enzymes to emit bioluminescence signals. This product is widely employed in the field of molecular imaging and bioluminescence assays due to its ability to track luciferase-expressing cells or organisms in vivo. It is a valuable tool for studying various diseases, including cancer, infectious diseases and neurological disorders. Molecular formula: C17H18N2O8S2. Mole weight: 442.47. | |
| D-Luciferin potassium | D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP [1]. We offer the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B). Uses: Scientific research. Group: Fluorescent dye. Alternative Names: D-(-)-Luciferin potassium; Firefly luciferin potassium; Beetle Luciferin potassium. CAS No. 115144-35-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-12591B. | |
| D-Luciferin potassium salt | D-Luciferin potassium salt is a chemiluminescent substrate of firefly luciferase. Synonyms: (4S)-4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic Acid Monopotassium Salt; 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, potassium salt (1:1), (4S)-; Firefly luciferin potassium salt. Grades: 95%. CAS No. 115144-35-9. Molecular formula: C11H7KN2O3S2. Mole weight: 318.41. | |
| D-Luciferin sodium | D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP [1]. We of er the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B). Uses: Scientific research. Group: Fluorescent dye. Alternative Names: D-(-)-Luciferin sodium; Firefly luciferin sodium; Beetle Luciferin sodium. CAS No. 103404-75-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12591. | |
| EDA-ATP - DYQ-660 | EDA-ATP, a nucleotide analogue frequently utilized in the biomedical industry, functions as a valuable substrate for luciferase-based assays designed to gauge ATP concentration and activity. Widely applicable in the study of various ailments including muscular dystrophy as well as drug efficacy in treating cancer and neurological disorders, its potential applications seem endless. When utilized in concert with DYQ-660, a fluorescent dye able to be coupled with EDA-ATP for purposes of imaging, this product provides a powerhouse duo for accurate measurement and imaging. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Adenosine-5'-triphosphate, labeled with DYQ 660, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C52H64N9O19P3S (free acid). Mole weight: 1244.11 (free acid). | |
| Ethaselen | Ethaselen, also known as BBSKE, is a novel organoselenium thioredoxin reductase inhibitor, is currently being investigated in a phase I clinical trial in China. Ethaselen enhanced the efficacy of radiation therapy both in vivo and in vitro without observable toxicity. BBSKE was found to suppress irradiation-induced activation dramatically when using A549 cells stably transfected with luciferase reporter. Ethaselen is a potentially promising agent for the treatment of patients with NSCLC clinically. Synonyms: 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane; BBSKE. CAS No. 217798-39-5. Molecular formula: C16H12N2O2Se2. Mole weight: 422.199. | |
| Ethynodiol | Ethynodiol is a steroidal progestin that inhibits luciferase expression. Uses: Contraceptives, oral, synthetic. Synonyms: (3β,17α)-19-Norpregn-4-en-20-yne-3,17-diol; 19-Nor-17α-pregn-4-en-20-yne-3β,17-diol. Grades: > 95%. CAS No. 1231-93-2. Molecular formula: C20H28O2. Mole weight: 300.44. | |
| Ethynodiol-17-Acetate | A derivative of Ethynodiol. Ethynodiol is a steroidal progestin that inhibits luciferase expression. Synonyms: (3β,17α)-19-Norpregn-4-en-20-yne-3,17-diol 17-Acetate; 19-Nor-17α-pregn-4-en-20-yne-3β,17-diol 17-Acetate. Grades: > 95%. CAS No. 2061-46-3. Molecular formula: C22H30O3. Mole weight: 342.48. | |
| Ethynodiol Impurity | An impurity of Ethynodiol. Ethynodiol is a steroidal progestin that inhibits luciferase expression. Synonyms: 17-alfa-Ethinyl-17-beta-Acettoxy-3,5-Estradien Impurity. Grades: > 95%. CAS No. 64850-62-0. Molecular formula: C22H28O2. Mole weight: 324.47. | |
| ETZ | ETZ (C3-CA-DTZ) is a promising luciferase substrate (prosubstrate) activatable in vivo by nonspecific esterase to enhance the brain delivery of the luciferin [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: C3-CA-DTZ. CAS No. 2989379-61-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145127. | |
| FMN Reductase from Escherichia coli (Fre), Recombinant | E.coli. Applications: Bacterial (e. coli) nad(p)h-dependent fmn-oxidoreductase is a recombinant protein of ca. 26kda overexpressed in e.coli. the sequence of cloned fre (swissprot accession number p0aen1) was confirmed by dna sequencing (100% identity). Group: Enzymes. Synonyms: NAD(P)H:flavin oxidoreduct. Enzyme Commission Number: EC 1.5.1.29. Mole weight: 26kDa. Activity: >2U/mg. Appearance: Coupling of bacterial luciferase to FMN-NAD(P)H oxidoreductase has been used to provide ultrasensitive analytical tools for thequantification of NADH and the substrates of NADH-, NADPH- dependent enzymes (e.g. glucose, lactate, malate, ethanol, sorbitol,oxaloacetate). Although FMN-reductase often present in luciferase enzyme preparations may be sufficient for producing light in the presence of NAD(P)H, highly purified and characterized Fre enzyme can offer some advantages such as an increased sensitivity,better control of the signal intensity and duration, and saving of the luciferase enzyme. Species: FMN Reductase. NAD(P)H:flavin oxidoreductase; NAD(P)H:flavin mono-nucleotide oxidoreductase; NAD(P)H(2):FMN oxidoreductase; NAD(P)H-FMN reductase; NAD(P)H-dependent FMN reductase; NAD(P)H:FMN oxidoreductase; riboflavin mononucleotide reductase; flavin mononucleotide reductase; EC 1.5.1.29. Pack: stable lyophilized form. Cat No: NATE-1744. | |
| FMN reductase (NADPH) | The enzymes from bioluminescent bacteria contain FMN, while the enzyme from Escherichia coli does not. The enzyme often forms a two-component system with monooxygenases such as luciferase. Unlike EC 1.5.1.39, this enzyme does not use NADH as acceptor. While FMN is the preferred substrate, the enzyme can also use FAD and riboflavin with lower activity. Group: Enzymes. Synonyms: FRP; flavin reductase P; SsuE. Enzyme Commission Number: EC 1.5.1.38. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1519; FMN reductase (NADPH); EC 1.5.1.38; FRP; flavin reductase P; SsuE. Cat No: EXWM-1519. | |
| Hh Signaling Antagonist XII, MRT-83 (N- (2-Methyl-5- (3- (3, 4, 5-trimethoxybenzoyl) guanidino) phenyl) - (1, 1-biphenyl) -4-carboxamide) | A cell-permeable acylguanidine compound that is shown to block Hh signaling and act as a potent, reversible and high-affinity Smo (Smoothened) antagonist. Displays 20-60 -fold greater potency than Cyclopamine and competitively inhibits bodipy-cyclopamine binding to Smo (IC50 = 4.6 and 14nM in HEK293-hSMO and HEK293-mSMO cells, respectively). Represses ShhN (N-myristoylated Shh) signaling (IC50=15nM for Gli-dependent luciferase activity in Shh-light2 cells) and SAG- induced C3H10T1/2 cell differentiation (IC50=10nM in an alkaline phosphatase activity assay). Inhibits ShhN (3nM) and SAG (10nM)-mediated proliferation of rat cerebellar granule cell precursors (IC50 ~3 and 6nM, respectively). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Hydroxyphenyl Fluorescein | Hydroxyphenyl Fluorescein (HPF) is a stable ROS fluorescent probe dye. Hydroxyphenyl Fluorescein has stronger specificity and stability than H2DCFDA (HY-D0940). Hydroxyphenyl Fluorescein can produce strong green fluorescence through hydroxyl radical reaction with intracellular peroxynitroso. Hydroxyphenyl Fluorescein can be applied for fluorescence microscopy, high-throughput imager, luciferase microplate reader or flow cytometry. Ex/Em=490/515 nm[1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: HPF; 3'-p-(Hydroxyphenyl) fluorescein. CAS No. 359010-69-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111330. | |
| iCRT 14 | iCRT 14 is a novel potent inhibitor of ?-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase. Uses: Scientific research. Group: Signaling pathways. CAS No. 677331-12-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16665. | |
| iCRT5 | iCRT5 is a Potent and cell-permeable β-catenin-responsive transcription (CRT) inhibitor (IC50 value of 18 nM for Wnt responsive STF16 luciferase). iCRT5 disrupts the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin. Synonyms: iCRT5; iCRT-5; iCRT 5; 4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid; 4-[(5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid; EN300-00774; AC1Q49FJ. Grades: 99%. CAS No. 18623-44-4. Molecular formula: C16H17NO5S2. Mole weight: 367.44. | |
| JNU-0921 | JNU-0921 is a potent and orally active CD137 agonist. JNU-0921 increases the mRNA expression of IFN-? and GZMB. JNU-0921 induces luciferase activity with an EC50 value of 64.07 nM.JNU-0921 enhances effector and memory function of cytotoxic CD8+ T cells (CTLs) and alleviates their exhaustion. JNU-0921 also skews polarization of helper T cells toward T helper 1 type and enhances their activity to boost CTL function. JNU-0921 shows anticancer activity[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161982. | |
| Ketodarolutamide | Ketodarolutamide (ORM-15341) is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 1896953; ORM-15341. CAS No. 1297537-33-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19337. | |
| Latia-luciferin monooxygenase (demethylating) | A flavoprotein. Latia is a bioluminescent mollusc. The reaction possibly involves two enzymes, an oxygenase followed by a monooxygenase for the actual light-emitting step. Group: Enzymes. Synonyms: luciferase (Latia luciferin); Latia luciferin monooxygenase (demethylating). Enzyme Commission Number: EC 1.14.99.21. CAS No. 62213-54-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1039; Latia-luciferin monooxygenase (demethylating); EC 1.14.99.21; 62213-54-1; luciferase (Latia luciferin); Latia luciferin monooxygenase (demethylating). Cat No: EXWM-1039. | |
| Lauroyl coenzyme A lithium salt | Lauroyl CoA is a substrate for FAM34A proteins and a product of firefly luciferase. Applications: A substrate for fam34a proteins. Group: Coenzymes. Synonyms: Dodecanoyl-Coenzyme A lithium salt. CAS No. 190063-12-8. Purity: ≥90%. Mole weight: 955.77. Appearance: Powder. Form: Solid. Dodecanoyl-Coenzyme A lithium salt; Lauroyl coenzyme A lithium salt; 190063-12-8. Cat No: COEC-056. | |
| long-chain acyl-protein thioester reductase | Together with a hydrolase component (EC 3.1.2.2 and EC 3.1.2.14) and a synthetase component (EC 6.2.1.19), this enzyme forms a multienzyme fatty acid reductase complex that produces the long-chain aldehyde substrate of the bacterial luciferase enzyme (EC 1.14.14.3). The enzyme is acylated by receiving an acyl group from EC 6.2.1.19, and catalyses the reduction of the acyl group, releasing the aldehyde product. The enzyme is also able to accept the acyl group from a long-chain acyl-CoA. Group: Enzymes. Synonyms: luxC (gene name); acyl-CoA reductase; acyl coenzyme A reductase; long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming); long-chain-fatty-acyl-CoA reductase. Enzyme Commission Number: EC 1.2.1.50. CAS No. 50936-56-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1154; long-chain acyl-protein thioester reductase; EC 1.2.1.50; 50936-56-6; luxC (gene name); acyl-CoA reductase; acyl coenzyme A reductase; long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming); long-chain-fatty-acyl-CoA reductase. Cat No: EXWM-1154. | |
| long-chain-fatty-acid-protein ligase | Together with a hydrolase component (EC 3.1.2.2/EC 3.1.2.14) and a reductase component (EC 1.2.1.50), this enzyme forms a multienzyme fatty acid reductase complex that produces the long-chain aldehyde substrate of the bacterial luciferase enzyme (EC 1.14.14.3). The enzyme activates free long-chain fatty acids, generated by the action of the transferase component, forming a fatty acyl-AMP intermediate, followed by the transfer of the acyl group to an internal L-cysteine residue. It then transfers the acyl group to EC 1.2.1.50, long-chain acyl-protein thioester reductase. Group: Enzymes. Synonyms: luxE (gene name); acyl-protein synthetase; long-chain-fatty-acid-luciferin-component ligase. Enzyme Commission Number: EC 6.2.1.19. CAS No. 82657-98-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5677; long-chain-fatty-acid-protein ligase; EC 6.2.1.19; 82657-98-5; luxE (gene name); acyl-protein synthetase; long-chain-fatty-acid-luciferin-component ligase. Cat No: EXWM-5677. | |
| lucPpy-IN-1 | lucPpy-IN-1 (compound 9) is an ATP-dependent luciferase from Photinus pyralis ( lucPpy ) inhibitor with an IC 50 value of 4.0 μM. lucPpy-IN-1 can be used for the research of targets agentgability [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 546100-66-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148407. | |
| LY 364947 | Selective inhibitor of TGF- β type-I receptor (TGF- β RI, TGFR-I, T βR-I, ALK-5) (IC50 values are 59, 400 and 1400nM for TGR- β RI, TGF- β RII and MLK-7K respectively). Inhibits TGF- β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay. Group: Biochemicals. Alternative Names: 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]quinoline; E 616451; HTS 466284. Grades: Highly Purified. CAS No. 396129-53-6. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H??N?, Molecular Weight: 272.3. US Biological Life Sciences. | Worldwide |
| LY-364947 | LY364947 is a selective inhibitor of TGF-β type-I receptor with potential anticancer activity. LY364947 inhibits TGF-β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3). Uses: Reprogramming. Synonyms: LY364947; LY-364947; LY 364947; HTS 466284; HTS466284; HTS-466284. Grades: 98%. CAS No. 396129-53-6. Molecular formula: C17H12N4. Mole weight: 272.31. | |
| M 25 | M 25 is a potent Smoothened (Smo) receptor antagonist with IC50 value of 5 nM. It inhibits the Hedgehog signaling pathway. It also inhibits Shh induced Gli luciferase reporter activity in Shh-light 2 cells. It antagonizes GSA-10 and SAG-mediated differentiation of the C3H10T1/2 cell line. Synonyms: M 25; M25; M-25; N-[[1-(2-Methoxyphenyl)-1H-indazol-5-yl]methyl]-2-propylpentanamide. Grades: ≥98% by HPLC. Molecular formula: C23H29N3O2. Mole weight: 379.50. | |
| MEISi-1 | MEISi-1 is a homeodomain inhibitor of small molecule MEIS1 protein. MEISi-1 significantly inhibited the activity of luciferase reporter genes containing MEIS binding sites (TGACAG) and induced self-renewal of mouse and human HSCS in vitro and in vivo. MEISi-1 can be used for research in blood diseases, heart regeneration and cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 446306-43-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134258. | |
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