Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Luciferase | Luciferase from Vibrio fischeri has also been used in a study to investigate the sensitivity of dark mutants of various strains of luminescent bacteria to reactive oxygen species. Uses: Scientific research. Group: Fluorescent dye. CAS No. 9014-00-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1004. |  |
| Luciferase | Luciferase is an analytical enzyme used as a component of lysis solution to measure luminescence signals. It has been used to investigate the sensitivity of dark mutants of various luminescent bacterial strains to reactive oxygen species. Synonyms: EC 1.14.14.3; Bacterial Luciferase; Luciferase from Photobacterium fischeri. Grade: >95%. CAS No. 9014-00-0. Molecular formula: H14. Mole weight: 14.11. |  |
| Luciferase, firefly | Luciferase, firefly is a bioluminescent enzyme responsible for bioluminescence in fireflies and click beetles. Synonyms: Luciferase from Photinus pyralis (firefly). Grade: >98%. CAS No. 61970-00-1. Molecular formula: C18H19N5O. Mole weight: 321.4. | |
| Luciferase, firefly | Luciferase, firefly is the light-emitting enzyme responsible for the bioluminescence of fireflies and click beetles. Uses: Scientific research. Group: Peptides. CAS No. 61970-00-1. Pack Sizes: 1 mg. Product ID: HY-P1004A. | |
| Luciferase from E. coli, Recombinant | Luciferase is an enzyme that catalyzes production of light from luciferin in the presence of Mg2+-ATP and oxygen. The reaction of this enzyme with luciferin, ATP, and O2 results in the emission of light. Luciferase activity can be inhibited by general anesthetics including isoflurane and ketamine/medetomidine thereby affecting the sensitivity of bioluminescence imaging. Group: Enzymes. Synonyms: Photinus-luciferin 4-monooxygenase (ATP-hydrolysing); firefly luciferase; luciferase (firefly luciferin); Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing); firefly luciferin luciferase; Photinus pyralis luciferase; EC 1.13.12.7; 61970-00-1. Enzyme Commission Number: EC 1.13.12.7. Luciferase. Mole weight: ca. 60 kDa. Activity: > 1.0 x 10^9 relative light units (RLU)/mg lyophilizate Specific activity: 1.4 x 10^11 RLU/mg purified protein. Stability: stable at 25°C for at least 5 days (liquid form). Appearance: White lyophilizate. Storage: at -20°C. Source: E. coli. Species: E. coli. Photinus-luciferin 4-monooxygenase (ATP-hydrolysing); firefly luciferase; luciferase (firefly luciferin); Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing); firefly luciferin luciferase; Photinus pyralis luciferase; EC 1.13.12.7; 61970-00-1. Cat No: NATE-1253. |  |
| Luciferase from Photinus pyralis (firefly), Recombinant | Firefly luciferase is an enzyme that catalyzes production of light from luciferin in the presence of Mg2+-ATP and oxygen. The reaction of this enzyme with luciferin, ATP, and O2 results in the emission of light. Luciferase activity can be inhibited by general anesthetics including isoflurane and ketamine/medetomidine thereby affecting the sensitivity of bioluminescence imaging. Applications: The reaction of this enzyme with luciferin, atp, and o2 results in the emission of light. luciferase can be used to detect trace amounts of atp. firefly luciferase is also one of the most commonly utilized reporter genes for the study of gene expression. the bioluminescent rea.pe I , > 5 ,000 ,000 units/mg protein; Type II, 15-30×106 light units/mg protein. Storage: -70°C. Form: Type I, Supplied as a solution in 50 mM Tris HCl pH 8.0, 1 mM dithiothreitol, 1 mM EDTA, and 10% (v/v) glycerol; Type II, Lyophilized powder approximately 20% protein; balance is primarily NaCl, HEPES buffer salts, and carbohydrate. Source: E. coli. Species: Photinus pyralis (firefly). Photinus-luciferin 4-monooxygenase (ATP-hydrolysing); firefly luciferase; luciferase (firefly luciferin); Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing); firefly luciferin luciferase; Photinus pyralis luciferase; EC 1.13.12.7; 61970-00-1. Cat No: NATE-0424. | |
| Luciferase from Vibrio fischeri | Luciferase from Vibrio fischeri. Group: Biochemicals. Grades: Highly Purified. CAS No. 9014-00-0. Pack Sizes: 100mg, 250mg, 500mg. US Biological Life Sciences. |  Worldwide |
| Luciferase from Vibrio fischeri (Photobacterium f) | lyophilized powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Luciferase-IN-4 | Luciferase-IN-4 (Compound 6b) is an inhibitor for luciferase with IC 50 of 4.1 μM. Luciferase-IN-4 inhibits purified luciferase in P. pyralis with IC 50 of 2.0 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1020413-85-7. Pack Sizes: 1 mg. Product ID: HY-161475. | |
| AMPK Signaling Activator XIII, ZLN005 (2-(4-tert-Butylphenyl)-1H-benzo[d]imidazole, 2-(4-(2-Methyl-2-propanyl)phenyl)-1H-benzimidazole, Luciferase Inhibitor IV) | A cell-permeable benzimidazole that, in addition to its inhibitory potency against luciferase activity (IC50 <10nM), also activates AMPK signaling by increasing cellular ADP/ATP ratio via mitochondria respiration upcoupling, effectively activating AMPK & PGC-1alpha in muscle, but not liver, cell types both in cultures (5-20uM in rat L6 myotubes) in vitro and in db/db mice (15mg/kg/day via p.o.) in vivo. Reported to improve glucose and insulin tolerance of db/db mice without any apparent effects on body weight or food intake. Group: Biochemicals. Grades: Highly Purified. CAS No. 4529-96-8. Pack Sizes: 25mg. Molecular Formula: C??H??N?. US Biological Life Sciences. | Worldwide |
| Anti-Luciferase antibody, Mouse monoclonal | clone LUC-1, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| bacterial luciferase | The reaction sequence starts with the incorporation of a molecule of oxygen into reduced FMN bound to the enzyme, forming luciferase peroxyflavin. The peroxyflavin interacts with an aliphatic long-chain aldehyde, producing a highly fluorescent species believed to be luciferase hydroxyflavin. The enzyme is highly specific for reduced FMN and for long-chain aliphatic aldehydes with eight carbons or more. The highest efficiency is achieved with tetradecanal. cf. EC 1.13.12.18, dinoflagellate luciferase. Group: Enzymes. Synonyms: aldehyde monooxygenase; luciferase; Vibrio fischeri luciferase; alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal monooxygenase (FMN); aldehyde,FMNH2:oxygen oxidoreductase (1-hyd. Enzyme Commission Number: EC 1.14.14.3. CAS No. 9014-00-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0927; bacterial luciferase; EC 1.14.14.3; 9014-00-0; aldehyde monooxygenase; luciferase; Vibrio fischeri luciferase; alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal monooxygenase (FMN); aldehyde,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing). Cat No: EXWM-0927. | |
| Biotinylated Luciferase from E. coli, Recombinant | Luciferase is an enzyme that catalyzes production of light from luciferin in the presence of Mg2+-ATP and oxygen. The reaction of this enzyme with luciferin, ATP, and O2 results in the emission of light. Luciferase activity can be inhibited by general anesthetics including isoflurane and ketamine/medetomidine thereby affecting the sensitivity of bioluminescence imaging. Group: Enzymes. Synonyms: Photinus-luciferin 4-monooxygenase (ATP-hydrolysing); firefly luciferase; luciferase (firefly luciferin); Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing); firefly luciferin luciferase; Photinus pyralis luciferase; EC 1.13.12.7; 61970-00-1. Enzyme Commission Number: EC 1.13.12.7. Luciferase. Mole weight: ca. 70 kDa. Activity: > 1.0 x 10^10 relative light units (RLU)/ml Specific activity: 1.9 x 10^11 RLU/mg purified protein. Stability: stable at 25°C for at least one week (liquid form). Appearance: Liquid form. Storage: at -20°C. Source: E. coli. Species: E. coli. Photinus-luciferin 4-monooxygenase (ATP-hydrolysing); firefly luciferase; luciferase (firefly luciferin); Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing); firefly luciferin luciferase; Photinus pyralis luciferase; EC 1.13.12.7; 61970-00-1. Cat No: NATE-1254. | |
| Clipos Luciferase mRNA Lipid Nanoparticles | Luciferase mRNA-LNPs from CD Bioparticles Drug Delivery is a trusted mRNA Lipid Nanoparticles to support your study on Liposomes for DNA/RNA Delivery. Group: Mrna lipid nanoparticles. |  |
| Clipos mCherry-Luciferase mRNA Lipid Nanoparticles | Improve your research in Liposomes for DNA/RNA Delivery with mCherry-Luciferase mRNA-LNPs, a high-quality mRNA Lipid Nanoparticles now available from CD Bioparticles. Group: Mrna lipid nanoparticles. | |
| dinoflagellate luciferase | A luciferase from dinoflagelates such as Gonyaulax polyedra, Lingulodinium polyedrum, Noctiluca scintillans, and Pyrocystis lunula. It is a single protein with three luciferase domains. The luciferin is strongly bound by a luciferin binding protein above a pH of 7. Group: Enzymes. Synonyms: (dinoflagellate luciferin) luciferase; Gonyaulax luciferase. Enzyme Commission Number: EC 1.13.12.18. CAS No. 303183-71-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0610; dinoflagellate luciferase; EC 1.13.12.18; 303183-71-3; (dinoflagellate luciferin) luciferase; Gonyaulax luciferase. Cat No: EXWM-0610. | |
| Firefly luciferase-IN-1 | Firefly luciferase-IN-1 (compound 48) is a highly potent and reversible inhibitor of firefly luciferase with an IC50 value of 0.25 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2765796-41-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-155945. | |
| Firefly luciferase-IN-1 | Firefly luciferase-IN-1 is a highly potent and reversible inhibitor of firefly luciferase with an IC50 value of 0.25 nM. Synonyms: (E)-6-(4-methylbenzylidene)-5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid. CAS No. 2765796-41-4. Molecular formula: C19H16O3. Mole weight: 292.33. | |
| Native Photinus pyralis (firefly) Luciferase | Firefly luciferase is an enzyme that catalyzes production of light from luciferin in the presence of Mg2+-ATP and oxygen. The reaction of this enzyme with luciferin, ATP, and O2 results in the emission of light. Luciferase activity can be inhibited by general anesthetics including isoflurane and ketamine/medetomidine thereby affecting the sensitivity of bioluminescence imaging. Applications: The reaction of this enzyme with luciferin, atp, and o2 results in the emission of light. luciferase can be used to detect trace amounts of atp. firefly luciferase is also one of the most commonly utilized reporter genes for the study of gene expression. the bioluminescent reaction. been used in a study to identify the different characteristics of reporter genes in whole-cell bacterial sensors. luciferase from photinus pyralis has also been used in a study to develop a novel bioluminogenic assay for α-chymotrypsin. Group: Enzymes. Synonyms: Photinus-luciferin 4-monooxygenase (ATP-hydrolysing); firefly luciferase; luciferase (firefly luciferin); Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing); firefly luciferin luciferase; Photinus pyralis luciferase; EC 1.13.12.7; 61970-00-1. Enzyme Commission Number: EC 1.13.12.7. CAS No. 9014-00-0. Luciferase. Mole weight: mol wt 120 kDa (two subunits). Form: Lyophilized powder appr. | |
| Native Photobacterium phosphoreum (Lux) Bacterial Luciferase | P. phosphoreum. Applications: Bacterial luciferase is purified from a photobacterium phosphoreum strain isolated from squid by our team and selected for its brightest luminescence. the luxab gene was amplified by pcr and cloned. the sequences of cloned α and β subunits have shown 94% and 92% identity to p24113 and p12744 proteins of photobacterium phosphoreum (swissprot entry). Group: Enzymes. Synonyms: aldehyde monooxygenase; luciferase; Vibrio fischeri luciferase; alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal monooxygenase (FMN); aldehyde,FMNH2:ox. presence of limiting concentrations of NADH substrate, light intensity is proportional to NAD(P)H concentration. The coupling of bacterial luciferase to FMN-NAD(P)H oxidoreductase has been used to provide ultrasensitive analytical tools for the quantification of NAD(P)H and the substrates of NADH-, NADPH- dependent enzymes (e.g. glucose, lactate, malate, ethanol, sorbitol, oxaloacetate).Bacterial Luciferase can be used for NAD(P)H quantification or in dehydrogenase-coupled assays.The enzyme is provided lyophilized, alone or with lyophilized FMN-reductase. Species: Luciferase. aldehyde monooxygenase; luciferase; Vibrio fischeri luciferase; alkanal,reduced-FMN:ox. | |
| Native Vibrio fischeri (Photobacterium f) Luciferase | In enzymology, an alkanal monooxygenase (FMN-linked) (EC 1.14.14.3) is an enzyme that catalyzes the chemical reaction:RCHO + reduced FMN + O2<-> RCOOH + FMN + H2O + hnu. The 3 substrates of this enzyme are RCHO, reduced FMN, and O2, whereas its 4 products are RCOOH, FMN, H2O, and hn. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor. Applications: Luciferase from vibrio fischeri has been used in a s.; aldehyde monooxygenase; luciferase; Vibrio fischeri luciferase; alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing); EC 1.14.14.3; 9014-00-0. Enzyme Commission Number: EC 1.13.12.7. CAS No. 9014-00-0. Luciferase. Form: lyophilized powder. Source: Vibrio fischeri (Photobacterium f). alkanal monooxygenase (FMN); bacterial luciferase; aldehyde monooxygenase; luciferase; Vibrio fischeri luciferase; alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing); alkanal,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing); EC 1.14.14.3; 9014-00-0. Cat No: NATE-0423. | |
| 17α-Ethinyl-17 β-acetoxy-3,5-estradiene | 17α-Ethinyl-17 β-acetoxy-3,5-estradiene is derived from Ethynodiol (E932120), which is a steroidal progestin that inhibits luciferase expression. Also, it is an impurity of the drug Norethindrone Acetate (N675990). Group: Biochemicals. Grades: Highly Purified. CAS No. 64850-62-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H28O2, Molecular Weight: 324.459999999999. US Biological Life Sciences. | Worldwide |
| 1,9-Nonanediol | 1,9-Nonanediol is found to be a general anesthetic that can inhibit the firefly luciferase enzyme from Photinus pyralis by competing with its normal substrate firefly luciferin. 1,9-Nonanediol can also inhibit the bacterial luciferase enzyme from Vibrio Harveyi by competing with the substrate n-decanal. Group: Biochemicals. Grades: Highly Purified. CAS No. 3937-56-2. Pack Sizes: 10g, 50g. Molecular Formula: C9H20O2, Molecular Weight: 160.25. US Biological Life Sciences. | Worldwide |
| 2-Chlorobenzaldehyde Oxime | 2-Chlorobenzaldehyde Oxime is a chemical reagent used in the synthesis of antimicrobial hydroxamates which are potential inhibitors of deoxy-D-xylulose 5-phosphate synthase inhibiting growth of influenzae. Also used in the preparation ofsubstituted oxazole based firefly luciferase inhibitors. Group: Biochemicals. Alternative Names: 2-Chlorobenzaldehyde oxime; 2-Chlorobenzaldoxime; NSC 61415; o-Chlorobenzaldehyde oxime; o-Chlorobenzaldoxime. Grades: Highly Purified. CAS No. 3717-28-0. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| 2-?Propyl-1,?3-?Dioxolane-?2-?acetic Acid | 2-?Propyl-1,?3-?Dioxolane-?2-?acetic Acid is an intermediate in synthesizing N-(Ketocaproyl)-L-homoserine Lactone (K180750), an autoinducer of P. fischeri luciferase. A specific genetic regulator that is unrelated to at least one of the enzyme systems that it induces, and it acts after excretion and accumulation in the extracellular medium. Group: Biochemicals. Grades: Highly Purified. CAS No. 5735-99-9. Pack Sizes: 500mg, 1g. Molecular Formula: C8H14O4. US Biological Life Sciences. | Worldwide |
| 2-Propyl-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-1,3-dioxolane-2-acetamide | 2-Propyl-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-1,3-dioxolane-2-acetamide is an intermediate in synthesizing N-(Ketocaproyl)-L-homoserine Lactone (K180750), an autoinducer of P. fischeri luciferase. A specific genetic regulator that is unrelated to at least one of the enzyme systems that it induces, and it acts after excretion and accumulation in the extracellular medium. Group: Biochemicals. Grades: Highly Purified. CAS No. 1083287-09-5. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H19NO5. US Biological Life Sciences. | Worldwide |
| 2-Undecanone | 2-Undecanone is a volatile organic compound, which inhibits the DnaKJE-ClpB bichaperone dependent refolding of heat-inactivated bacterial luciferases. 2-Undecanone inhibits lung tumorigenesis [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 112-12-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W016969. | |
| 5-(4-Methoxyphenyl)-2-pyridinamine | Used in the preparation of luciferase inhibitors, substituted triazoles as antifungal agents and PhIP (A617000) metabolites and derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 503536-75-2. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 6-Amino-D-luciferin | 6-Amino-D-luciferin is a D-luciferin (HY-12591A) with its 6-position hydroxyl group substituted with an amino group. D-luciferin is the natural substrate of the enzyme luciferase (Luc) [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 161055-47-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-126994. | |
| 6-Iodonordihydrocapsaicin | 6-Iodonordihydrocapsaicin is a potent and competitive vanilloid TRPV1 (VR1) receptor antagonist with IC50 value of 10 nM. It inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons. It also inhibits guinea pig bladder and trachea contractions in vitro. It may induce luciferase gene expression. Synonyms: N-[(4-Hydroxy-2-iodo-5-methoxyphenyl)methyl]nonanamide; 6-I-CPS. Grade: ≥99% by HPLC. CAS No. 859171-97-4. Molecular formula: C17H26INO3. Mole weight: 419.30. | |
| AkaLumine hydrochloride | AkaLumine hydrochloride is a D-luciferin (HY-12591A) analogue with a Km of 2.06 ?M for recombinant firefly luciferase (Fluc) protein. AkaLumine hydrochloride emits near-infrared (NIR) light (?max=677?nm) in reactions with native Fluc. AkaLumine hydrochloride has high tissue-penetration and increases detection sensitivity from deep-tissue targets[1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2558205-28-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112641A. | |
| ALC-0315 LNP-Cap 1 Fluc mRNA | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is capped with the CAP 1 structure. It is only for research purposes. Group: Lipid nanoparticle. |  |
| ALC-0315 LNP-Cap 1 Fluc mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is capped with the CAP 1 structure and modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| ALC-0315 LNP-Fluc mRNA | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| ALC-0315 LNP-Fluc mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| Alisol B 23-Acetate | Alisol B 23-acetate (23-Acetylalismol B), a natural triterpenoid, produces protective effects against EE-induced cholestasis, due to FXR-mediated gene regulation.IC50 Value:Target: Anti-hepatotoxic natural product.In vitro: Alisol-B 23-acetate has an effect on FXR activation in a dose-dependent manner using luciferase reporter assay in HepG2 cells.In vivo: In alisol B 23-acetate-treated mice, the changes in transporters and enzymes, as well as ameliorative liver histology were abrogated by FXR antagonist guggulsterone. Alisol B 23-acetate treatment in a dose-dependent manner resulted in protection against hepatotoxicity induced by CCl4via FXR activation. Through FXR activation, alisol B 23-acetate promoted hepatocyte proliferation via an induction in hepatic levels of FoxM1b, Cyclin D1 and Cyclin B1. Alisol B 23-acetate also reduced hepatic bile acids through a decrease in hepatic uptake transporter Ntcp, bile acid synthetic enzymes Cyp7a1, Cyp8b1, and an increase in efflux transporter Bsep, Mrp2 expression. In addition, alisol B 23-acetate induced the expression of STAT3 phosphorylation, and STAT3 target genes Bcl-xl and SOCS3, resulting in decreased hepatocyte apoptosis. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: White powder. CAS No. 26575-95-1. Molecular formula: C32H50O5. Mole weight: 514.8. Purity: 0.98. IUPACName: [1-(3,3-dimethyloxiran-2-yl)-3-[(8S,1 |  |
| CCG-100602 | CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells with an IC50 value of 9.8 μM. CCG-100602 specifically blocks the nuclear localization of MRTF-A, thereby inhibiting the fibrogenic transcription factor SRF. Synonyms: CCG-100602; 1207113-88-9; 1-[3,5-bis(trifluoromethyl)benzoyl]-N-(4-chlorophenyl)piperidine-3-carboxamide; CHEMBL603141; compound 4g [PMID: 19963382]; 1-(3,5-bis(trifluoromethyl)benzoyl)-N-(4-chlorophenyl)piperidine-3-carboxamide; CCG100602; CCG 100602; GTPL6764; SCHEMBL1534209; BDBM50436237; AKOS040744973; MS-28902; HY-120855; CS-0079376; Q27075763; [3,5-bis(trifluoromethyl)benzoyl]-N-(4-chlorophenyl)piperidine-3-carboxamide; 1-[3,5-bis (trifluoromethyl)benzoyl]-N-(4-chlorophenyl)-3-piperidinecarboxamide. Grade: 98%. CAS No. 1207113-88-9. Molecular formula: C21H17ClF6N2O2. Mole weight: 478.8. | |
| CCG-203971 | CCG-203971 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC50 =6.4 ?M). CCG-203971 inhibits PC-3 cell migration with an IC50 of 4.2 ?M. Potential anti-metastasis Agent[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1443437-74-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108361. | |
| Cetrorelix Acetate | Cetrorelix Acetate is the acetate salt of cetrorelix, which is a potent and synthetic peptide antagonist of gonadotropin-releasing hormone (GnRH) receptor antagonist with IC50 value of 1.21 nM. It binds to radioligand murine LTK- cells with Kd value of 0.2 nM. It inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH. It suppresses production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. It prevents ovulation during in vitro fertilization. It causes prepubertal reduction in bone density, bone strength and bone modeling. It was used as a therapeutic agent for the treatment of blood cancers such as multiple myeloma (MM). It is also used to treat hormone-sensitive cancers of the breast and prostate. It also has antidepressant and anxiolytic activity in vivo. Uses: Fertility agents, female. Synonyms: D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-, acetate (1:x); D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-, acetate (salt); Cetrotid; C. Grade: >98%. CAS No. 145672-81-7. Molecular formula: C70H92ClN17O14.xC2H4O2. Mole weight: 1431.06 (free base) | |
| CH-223191 | CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor ( AhR ). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC 50 of 0.03 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301326-22-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12684. | |
| CID 1375606 | CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27. Promotes recruitment of β-arrestin 2 to chimeric GPR27V2 and wild-type GPR27 in a firefly luciferase complementation assay (pEC50 values are 6.34 and 5.1, respectively). GPR27 is characterized by a high level of conservation among vertebrates and a predominant expression in the central nervous system. In addition, it has recently been linked to insulin secretion. Synonyms: 2,4-Dichloro-N-(phenylcarbamoyl)phenylbenzamide; 2,4-Dichloro-N-(4-(phenylcarbamoyl)phenyl)benzamide. Grade: ≥98% by HPLC. CAS No. 313493-80-0. Molecular formula: C20H14Cl2N2O2. Mole weight: 385.24. | |
| Coelenteramine 400a | Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm[1][2]. Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET)[3]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Coelenterazine 400a; Bisdeoxycoelenterazine. CAS No. 70217-82-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-118462. | |
| Coelenterazine | Coelenterazine is a luciferin, a light-emitting biomolecule that serves as a substrate for luciferases or as a constituent of photoproteins, including aequorin.1 The oxidation of coelenterazine to coelenteramide is accompanied by emission of blue light (emission maximum, 460-470 nm). Luciferase-mediated oxidation of coelenterazine or a derivative is used as an energy donor, typically to a form of green or yellow fluorescent protein, in bioluminescent resonance energy transfer studies.2,3 Alternatively, the calcium-mediated release of coelenterazine from aequorin, followed by non-enzymatic oxidation of this compound, results in bioluminescence. As light emission depends on both calcium and cellular redox status, this reaction is used to non-fluorescently detect changes in calcium level and redox status.4,5. Group: Biochemicals. Alternative Names: 3,2-Dihydro-2-(p-hydroxybenzyl)-6-(p-hydroxyphenyl)-8-benzylimidazolo[1,2-a]pyrazin-3-one; CLZN; Preluciferin; Luciferin; 6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-imidazo[1,2-a]pyrazin-3(7H)-one. Grades: Highly Purified. CAS No. 55779-48-1. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C??H??N?O?, Molecular Weight: 423.46. US Biological Life Sciences. | Worldwide |
| Coelenterazine | Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 55779-48-1. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18743. | |
| CP21R7 | CP21R7 is a potent and selective GSK3β inhibitor. It acts as an activator of stem cells prior to the induction of differentiation of stem cells to endothelial and smooth muscle cells. Uses: Cp21r7 is a selective gsk-3β inhibitor which could probably influence luciferase activity at some extent. Synonyms: 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione. Grade: >98%. CAS No. 125314-13-8. Molecular formula: C19H15N3O2. Mole weight: 317.34. | |
| CycLuc1 | CycLuc1 is a blood-brain barrier permeable luciferase substrate that displays near-infrared (NIR) emission with a peak luminescence wavelength of 599 nm. CycLuc1 can be used for in vivo bioluminescence imaging[1][2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1247879-16-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111653. | |
| Cypridina-luciferin 2-monooxygenase | Cypridina is a bioluminescent crustacea. The luciferins (and presumably the luciferases, since they cross-react) of some luminous fish (e.g. Apogon, Parapriacanthus, Porichthys) are apparently similar. The enzyme may be assayed by measurement of light emission. Group: Enzymes. Synonyms: Cypridina-type luciferase; luciferase (Cypridina luciferin); Cypridina luciferase. Enzyme Commission Number: EC 1.13.12.6. CAS No. 61969-99-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0619; Cypridina-luciferin 2-monooxygenase; EC 1.13.12.6; 61969-99-1; Cypridina-type luciferase; luciferase (Cypridina luciferin); Cypridina luciferase. Cat No: EXWM-0619. | |
| Decyl aldehyde | Decyl aldehyde is a simple ten-carbon aldehyde. Decyl aldehyde is a bacterial luciferase substrate. Uses: Scientific research. Group: Natural products. CAS No. 112-31-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-W012570. | |
| DiD-Labeled ALC-0315 LNP-Fluc mRNA | This product is a DiD-labeled LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiD-Labeled DLin-MC3-DMA LNP-Fluc mRNA | This product is a DiD-labeled LNP prepared with ionizable lipid (DLin-MC3-DMA), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiD-Labeled LP-01 LNP-Fluc mRNA | This product is a DiD-labeled LNP prepared with ionizable lipid (LP-01), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiD-Labeled SM102 LNP-Fluc mRNA | This product is a DiD-labeled LNP prepared with ionizable lipid (SM102), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiI-Labeled ALC-0315 LNP-Fluc mRNA | This product is a DiI-labeled LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiI-Labeled DLin-MC3-DMA LNP-Fluc mRNA | This product is a DiI-labeled LNP prepared with ionizable lipid (DLin-MC3-DMA), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiI-Labeled LP-01 LNP-Fluc mRNA | This product is a DiI-labeled LNP prepared with ionizable lipid (LP-01), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiI-Labeled SM102 LNP-Fluc mRNA | This product is a DiI-labeled LNP prepared with ionizable lipid (SM102), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiO-Labeled ALC-0315 LNP-Fluc mRNA | This product is a DiO-labeled LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiO-Labeled DLin-MC3-DMA LNP-Fluc mRNA | This product is a DiO-labeled LNP prepared with ionizable lipid (DLin-MC3-DMA), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiO-Labeled LP-01 LNP-Fluc mRNA | This product is a DiO-labeled LNP prepared with ionizable lipid (LP-01), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiO-Labeled SM102 LNP-Fluc mRNA | This product is a DiO-labeled LNP prepared with ionizable lipid (SM102), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiR-Labeled ALC-0315 LNP-Fluc mRNA | This product is a DIR-labeled LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiR-Labeled DLin-MC3-DMA LNP-Fluc mRNA | This product is a DIR-labeled LNP prepared with ionizable lipid (DLin-MC3-DMA), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiR-Labeled LP-01 LNP-Fluc mRNA | This product is a DIR-labeled LNP prepared with ionizable lipid (LP-01), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiR-Labeled SM102 LNP-Fluc mRNA | This product is a DIR-labeled LNP prepared with ionizable lipid (SM102), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DLin-MC3-DMA LNP-Cap 1 Fluc mRNA | This product is a LNP prepared with ionizable lipid (DLin-MC3-DMA), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is capped with the CAP 1 structure. It is only for research purposes. Group: Lipid nanoparticle. | |
| DLin-MC3-DMA LNP-Cap 1 Fluc mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (DLin-MC3-DMA), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is capped with the CAP 1 structure and modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| D-Luciferin | D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP [1]. We of er the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B). Uses: Scientific research. Group: Fluorescent dye. Alternative Names: D-(-)-Luciferin; Firefly luciferin; Beetle Luciferin. CAS No. 2591-17-5. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-12591A. | |
| D-Luciferin-6-O b-D-galactopyranoside | D-Luciferin-6-O b-D-galactopyranoside is a versatile tool in compound utilized for studying the activity of luciferase enzymes in various research applications. This compound is commonly employed in in vitro and in vivo bioluminescence imaging assays is aiding in the investigation of gene expressions, protein interactions and visualization of cellular processes. Synonyms: 6-O-(b-D-Galactopyranosyl)luciferin; 4-Thiazolecarboxylic acid, 2-[6-(β-D-galactopyranosyloxy)-2-benzothiazolyl]-4,5-dihydro-, (4S)-; (4S)-2-[6-(β-D-Galactopyranosyloxy)-2-benzothiazolyl]-4,5-dihydro-4-thiazolecarboxylic acid; 4-Thiazolecarboxylic acid, 2-[6-(β-D-galactopyranosyloxy)-2-benzothiazolyl]-4,5-dihydro-, (S)-; Lugal. CAS No. 131474-38-9. Molecular formula: C17H18N2O8S2. Mole weight: 442.47. | |
| D-Luciferin-6-O-b-D-glucopyranoside | D-Luciferin-6-O b-D-glucopyranoside is a crucial compound acting as a useful substrate for luciferase enzymes to emit bioluminescence signals. This product is widely employed in the field of molecular imaging and bioluminescence assays due to its ability to track luciferase-expressing cells or organisms in vivo. It is a valuable tool for studying various diseases, including cancer, infectious diseases and neurological disorders. Synonyms: (S)-2-(6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid; (4S)-2-[6-(β-D-Glucopyranosyloxy)-2-benzothiazolyl]-4,5-dihydro-4-thiazolecarboxylic acid; 4-Thiazolecarboxylic acid, 2-[6-(β-D-glucopyranosyloxy)-2-benzothiazolyl]-4,5-dihydro-, (S)-; 4-Thiazolecarboxylic acid, 2-[6-(β-D-glucopyranosyloxy)-2-benzothiazolyl]-4,5-dihydro-, (4S)-; D-Luciferin-6-O b-D-glucopyranoside. CAS No. 131474-37-8. Molecular formula: C17H18N2O8S2. Mole weight: 442.47. | |
| D-Luciferin potassium | D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP [1]. We offer the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B). Uses: Scientific research. Group: Fluorescent dye. Alternative Names: D-(-)-Luciferin potassium; Firefly luciferin potassium; Beetle Luciferin potassium. CAS No. 115144-35-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-12591B. | |
Our database is helping our users find suppliers everyday.
